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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATP2B4 Gene

protein-coding GIFtS: 64
GCID: GC01P203595

ATPase, Ca++ transporting, plasma membrane 4

(Previous name: matrix-remodelling associated 1 )
(Previous symbols: ATP2B2, MXRA1)

Explore 11 diseases affiliated with
ATP2B4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ATPase, Ca++ Transporting, Plasma Membrane 4¹ ²		PMCA4b²
ATP2B2¹ ² ³ ⁵		PMCA4x²
PMCA4¹ ² ³ ⁵		Plasma Membrane Calcium-Transporting ATPase 4²
MXRA1¹ ² ³		Sarcolemmal Calcium Pump²
Matrix-Remodeling-Associated Protein 1² ³		Plasma Membrane Calcium ATPase Isoform 4³
EC 3.6.3.8³ ⁸		Plasma Membrane Calcium Pump Isoform 4³
Matrix-Remodelling Associated 1¹		EC 3.6.3⁸

External Ids:	HGNC: 817¹	Entrez Gene: 493²	Ensembl: ENSG00000058668⁷	OMIM: 108732⁵	UniProtKB: P23634³

Export aliases for ATP2B4 gene to outside databases

Previous GC identifers: GC01P201313 GC01P199112 GC01P199956 GC01P200773 GC01P200327 GC01P201862 GC01P174761

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP2B4:

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the

formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions

from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium

homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the

diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different

isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that

these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the

plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have

been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AT2B4_HUMAN, P23634

Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of

the cell

Gene Wiki entry for ATP2B4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATP2B4 gene promoter:
STAT1 ISGF-3 USF1 AML1a MAZR Pax-5 STAT1beta S8 Ik-2 USF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP2B4 promoter sequence

Search SABiosciences Chromatin IP Primers for ATP2B4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP2B4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

ATP2B4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP2B4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P203595: view genomic region (about GC identifiers)

Start:	203,595,689 bp from pter	End:	203,713,209 bp from pter
Size:	117,521 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AT2B4_HUMAN, P23634 (See protein sequence)

Recommended Name: Plasma membrane calcium-transporting ATPase 4

Size: 1241 amino acids; 137920 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

2 PDB 3D structures from and Proteopedia for ATP2B4:

1CFF (3D)

2KNE (3D)

Secondary accessions: B1APW5 B1APW6 Q13450 Q13452 Q13455 Q16817 Q7Z3S1

Alternative splicing: 8 isoforms: P23634-1 P23634-2 P23634-3 P23634-4 P23634-5 P23634-6 P23634-7 P23634-8

Explore the universe of human proteins at neXtProt for ATP2B4: NX_P23634

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23634

4/41 DME Specific Peptides for ATP2B4 (P23634) (see all 41)

QFQLTVN

SSLTGES

IRNEKGE

VGNKTEC

ATP2B4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001001396.1 NP_001675.3

ENSEMBL proteins:

ENSP00000350310 ENSP00000340930 ENSP00000391150 ENSP00000349165 ENSP00000433577

ENSP00000356187 ENSP00000356188 ENSP00000375816

Reactome Protein details: P23634
Human Recombinant Protein Products:

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	Uscn Proteins for ATP2B4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	2137451

ATP2B4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ATP2B4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATP2B4 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR023298 ATPase_P-typ_TM_dom

IPR023306 ATPase_cation_domN

IPR008250 ATPase_P-typ_transduc_dom_A

IPR006408 ATPase_P-typ_Ca-transp_plasma

IPR023214 HAD-like_dom

Graphical View of Domain Structure for InterPro Entry P23634

ProtoNet protein and cluster: P23634

2 Blocks protein families:

IPB001757 ATPase

IPB008250 E1-E2 ATPase-associated region

UniProtKB/Swiss-Prot: AT2B4_HUMAN, P23634

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AT2B4_HUMAN, P23634

Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of

the cell

Catalytic activity: ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)

Genatlas biochemistry entry for ATP2B4:

ATPase,Ca++ transporting,B4 plasma membrane,mediating the extrusion of CA2+ from the cell

Enzyme Numbers (IUBMB): EC 3.6.3.8¹ ² EC 3.6.3²

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP2B4

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005388	calcium-transporting ATPase activity	IEA	--
GO:0005515	protein binding	IPI	11274188
GO:0005516	calmodulin binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0030165	PDZ domain binding	--	--

ATP2B4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for ATP2B4: Atp2b4^tm1Ksch Atp2b4^tm1Ges
     5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Atp2b4):

behavior/neurological

cardiovascular system

immune system

muscle

reproductive system

ATP2B4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet calcium homeostasis

Platelet calcium homeostasis

1.00

Reduction of cytosolic Ca++ levels

0.53

Ion channel transport

Ion channel transport

1.00

Ion transport by P-type ATPases

0.32

B Cell Receptor Signaling Pathway

B Cell Receptor Signaling Pathway

1.00

Pancreatic secretion

Pancreatic secretion

1.00

Calcium signaling pathway

Calcium signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for ATP2B4

B Cell Receptor Signaling Pathway

5/7 Reactome Pathways for ATP2B4 (see all 7)

	Hemostasis
	Transmembrane transport of small molecules
	Ion channel transport
	Platelet homeostasis
	Ion transport by P-type ATPases

3 Kegg Pathways (Kegg details for ATP2B4):

	Calcium signaling pathway
	Salivary secretion
	Pancreatic secretion

ATP2B4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ATP2B4

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/30 Interacting proteins for ATP2B4 (P23634^{1, 2, 3} ENSP00000350310⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALCA	P01258²^,³, ENSP00000331746⁴	MINT-5204003 MINT-5203983 I2D: score=1 STRING: ENSP00000331746
DLG1	Q12959²^,³, ENSP00000345731⁴	MINT-73083 I2D: score=4 STRING: ENSP00000345731
DLG2	Q15700²^,³, ENSP00000365272⁴	MINT-73082 I2D: score=4 STRING: ENSP00000365272
YWHAE	P62258²^,³, ENSP00000264335⁴	MINT-8007179 I2D: score=1 STRING: ENSP00000264335
CASK	O14936³, ENSP00000367408⁴	I2D: score=4 STRING: ENSP00000367408

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003407	neural retina development	--	--
GO:0006754	ATP biosynthetic process	IEA	--
GO:0006810	transport	TAS	2137451
GO:0006816	calcium ion transport	--	--
GO:0007596	blood coagulation	TAS	--

ATP2B4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ATP2B4 for compounds About GeneDecksing

EMD Millipore small molecules for ATP2B4:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ATP2B4

6 HMDB Compounds for ATP2B4 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Calcium	Ca (see all 2)	7440-70-2	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

3 Novoseek chemical compound relationships for ATP2B4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
p-mca	91	5	16452157 (2), 8700162 (1), 12359307 (1)
calcium	55.5	16	19755660 (3), 16978418 (2), 8187550 (1), 7554945 (1) (see all 9)
atp	29.3	3	7929331 (1), 12851406 (1)

Search CenterWatch for drugs/clinical trials and news about ATP2B4 / AT2B4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATP2B4 gene (2 alternative transcripts):

NM_001001396.2 NM_001684.4

Unigene Cluster for ATP2B4:

ATPase, Ca++ transporting, plasma membrane 4

Hs.343522 [show with all ESTs]

Unigene Representative Sequence: BX537444

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000357681(uc001gzw.3) ENST00000341360 ENST00000458092 ENST00000466407

ENST00000356729 ENST00000484746 ENST00000367218(uc009xaq.3 uc001gzv.3)

ENST00000367219(uc001gzx.3) ENST00000391954(uc009xar.3)

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		hsa-miR-520f hsa-miR-607 hsa-miR-3074-3p hsa-miR-502-3p hsa-miR-877* hsa-miR-376c hsa-miR-761 hsa-miR-92b

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Additional cDNA sequence:

AK026443.1 AK292458.1 AK307104.1 BC140774.1 BC150293.1 BX537444.1 BX537745.1 BX647701.1

CR749393.1 CR936708.1 DQ201780.1 DQ201781.1 M25874.1 M83363.1 U42026.1 U42061.1

U42062.1 U42378.1

19 DOTS entries:

DT.100892460 DT.100785137 DT.95096661 DT.97787189 DT.95271427 DT.111850 DT.121362820 DT.456214

DT.121362917 DT.40248724 DT.75144554 DT.121362854 DT.432584 DT.95221941 DT.95251749 DT.95354157

DT.97844329 DT.121362855 DT.87014818

24/349 AceView cDNA sequences (see all 349):

CA436086 AI565911 CR622884 AW239322 CB136898 CB216798 CA389647 BX503964

BF445962 AA865620 AA350133 BE384169 BQ446645 AW192926 BE855954 U42061

Z42673 AW167167 AA376080 BF724145 AA338194 AL598568 AI678822 BU183045

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ATP2B4 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24
SP1:
SP2:																																																	-
SP3:			-		-
SP4:					-
SP5:

ECgene alternative splicing isoforms for ATP2B4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATP2B4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCACTTGTA

About this image

ATP2B4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ATP2B4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATP2B4

SOURCE GeneReport for Unigene cluster: Hs.343522

UniProtKB/Swiss-Prot: AT2B4_HUMAN, P23634

Tissue specificity: Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment

Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain

cortex

SABiosciences Custom PCR Arrays for ATP2B4

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP2B4 gene from 7/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ATP2B4¹	ATPase, Ca++ transporting, plasma membrane 4	76.85(n) 82.68(a)		419934 XM_418055.3 XP_418055.3
lizard (Anolis carolinensis)	Reptilia	ATP2B4⁶	--	80(a)	1 ↔ 1	4(118128604-118190039)
zebrafish (Danio rerio)	Actinopterygii	57074411²	--	78.41(n)		57074411
fruit fly (Drosophila melanogaster)	Insecta	BEST:CK01140³	calcium-transporting ATPase	63(a)		102B5 --
worm (Caenorhabditis elegans)	Secernentea	R05C11.3³	ATPase	58(a) (best of 2)		IV(2084056-2091420) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ACA1¹	autoinhibited Ca2+-ATPase 1	50.98(n) 44.58(a)		839670 NM_179385.1 NP_849716.1
rice (Oryza sativa)	Liliopsida	Os.24860²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	72.84(n)		AK065088.1

ENSEMBL Gene Tree for ATP2B4 (if available)
TreeFam Gene Tree for ATP2B4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ATP2B4 gene

ATP2B1² ATP2B2² ATP2B3²

6 SIMAP similar genes for ATP2B4 using alignment to 7 protein entries: AT2B4_HUMAN (see all proteins):

DKFZp686M088 ATP2B2 ATP2B2 variant protein ATP2B3 PMCA2 ATP2B1

ATP2B4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113421787^1,2		--	174759884(+)	`ACCCCA/GTCTCT`	2	--	us2k¹		1		CSA	1
rs12122687^1,2	C,H	--	174760287(+)	`GGTTAG/AAATGA`	2	--	us2k¹		4		NS EA	420
rs12122722^1,2	H	--	174760392(+)	`TGTGAG/AACATA`	2	--	us2k¹		4		NS EA	420
rs59955742^1,2		--	174760498(+)	`GCTGAT/CGGTGC`	2	--	us2k¹		1		WA	118
rs112309900^1,2		--	174761284(+)	`CCACTC/TCCCAC`	2	--	us2k¹		1		CSA	2
rs76857273^1,2	C,	--	174761884(+)	`CCCTAC/TCNNNN`	2	--	ut5¹		4		CSA WA NA	241
rs113901324^1,2		--	174762050(+)	`TCTAGC/AATATT`	2	--	int¹		1		CSA	2
rs114650573^1,2	C,F,	--	174762395(+)	`GCCCAA/GAAGAG`	2	--	int¹		1		WA	118
rs75802498^1,2	F,	--	174762973(+)	`CTCTTG/TGTAGA`	2	--	int¹		1		WA	118
rs199714047^1,2	C	--	174763045(+)	`AGGGTA/CCNNNN`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ATP2B4 (203595689 - 203713209 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ATP2B4
1 CNV: 65686
2 Indels: 74864 84793
Human Gene Mutation Database (HGMD): ATP2B4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ATP2B4 for disorders           About GeneDecksing

OMIM gene information: 108732    OMIM disorders: --

11 diseases for ATP2B4:    About MalaCards

essential hypertension scoliosis breast cancer hypertension

colon cancer pneumonia schizophrenia tuberculosis

pancreatitis neuronitis mycobacterium tuberculosis

3 Novoseek disease relationships for ATP2B4 gene About this table

Disease	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	3	11713265 (1), 12509464 (1), 19755660 (1)
breast cancer	3	16216224 (2), 12359307 (1)
tumors	3	11713265 (1), 12509464 (1), 19755660 (1)

Human Genome Epidemiology (HuGE) Navigator: ATP2B4 (2 documents)

Export disorders for ATP2B4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ATP2B4 gene, integrated from 9 sources (see all 100):
(articles sorted by number of sources associating them with ATP2B4)

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Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. (PubMed id 1531651)^{1, 2, 9} Brandt P.... Vanaman T.C. (1992)
Analysis of mRNA expression and cloning of a novel plasma membrane Ca(2+)-ATPase splice variant in human heart. (PubMed id 8700162)^{1, 2, 9} Santiago-Garcia J.... Zarain-Herzberg A. (1996)
Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. (PubMed id 7989379)^{1, 2} Stauffer T.P....Strehler E.E. (1994)
Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. (PubMed id 8245032)^{1, 2} Stauffer T.P.... Strehler E.E. (1993)
Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23. (PubMed id 1674727)^{1, 3} Olson S....McBride O.W. (1991)
Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane. (PubMed id 2137451)^{1, 2} Strehler E.E.... Carafoli E. (1990)
A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase. (PubMed id 2966397)^{1, 2} Brandt P.... Vanaman T.C. (1988)
Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes. (PubMed id 2963820)^{1, 2} James P....Carafoli E. (1988)
Plasma membrane calcium ATPase 4 and the remodeling o f calcium homeostasis in human colon cancer cells. (PubMed id 19755660)^{1, 9} Aung C.S....Roberts-Thomson S.J. (2009)
Plasma membrane calcium ATPase (PMCA4): a housekeeper for RT-PCR relative quantification of polytopic membrane proteins. (PubMed id 16978418)^{1, 9} Calcagno A.M....Ambudkar S.V. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 493	HGNC: 817	AceView: ATP2B4	Ensembl:ENSG00000058668	euGenes: HUgn493
ECgene: ATP2B4	Kegg: 493	H-InvDB: ATP2B4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ATP2B4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ATP2B4 gene
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Patent Information for ATP2B4 gene:
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GeneCards and IP:
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ATP2B4 Gene

ATPase, Ca++ transporting, plasma membrane 4

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ATP2B4 Gene

ATPase, Ca++ transporting, plasma membrane 4

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