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ATP2B2 Gene

protein-coding GIFtS: 63

GC03M010342

ATPase, Ca++ transporting, plasma membrane 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 3.6.3.8 ^³
OTTHUMP00000178534 ^²
OTTHUMP00000178537 ^²
PMCA2 ^¹, ², ³, ⁵
PMCA2a ^²
PMCA2i ^²

Descriptions
ATPase, Ca++ transporting, plasma membrane 2 ^²
Plasma membrane calcium ATPase isoform 2 ^³
Plasma membrane calcium pump isoform 2 ^³
plasma membrane Ca(2+)-ATPase ^²
plasma membrane Ca2+ pump 2 ^²
plasma membrane calcium ATPase 2 ^²
plasma membrane calcium pump ^²

External Ids
HGNC: 815¹
Entrez Gene: 491²
UniProtKB: Q01814³
Ensembl: ENSG00000157087⁷

Search outside databases for aliases for ATP2B2 gene

Previous GC identifers: GC03M010298 GC03M010344

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ATP2B2:

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases

characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle.

These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration

gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma

membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of

these enzymes is further increased by alternative splicing of transcripts. The expression of

different isoforms and splice variants is regulated in a developmental, tissue- and cell

type-specific manner, suggesting that these pumps are functionally adapted to the physiological

needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase

isoform 2. Alternatively spliced transcript variants encoding different isoforms have been

identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: AT2B2_HUMAN, Q01814

Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the

transport of calcium out of the cell

Gene Wiki entry for ATP2B2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ATP2B2 gene

Entrez Gene cytogenetic band: 3p25.3 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25.3

ATP2B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M010342: (about GC identifiers)

Start:	10,340,707 bp from pter
End:	10,724,716 bp from pter
Size:	384,010 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AT2B2_HUMAN, Q01814 (See protein sequence)

Recommended Name: Plasma membrane calcium-transporting ATPase 2

Size: 1243 amino acids; 136876 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: O00766 Q12994 Q16818

Alternative splicing: 6 isoforms: Q01814-1 Q01814-2 Q01814-3 Q01814-4 Q01814-5 Q01814-6 (There is a combination of two alternative spliced domains at N-terminal site A (W, X and Z) and at C-terminal site C (A and B). So far the splice sites have only been studied independently. Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001001331.1 NP_001674.2

ENSEMBL proteins:

ENSP00000380267 ENSP00000342954 ENSP00000373311 ENSP00000353414 ENSP00000344677 ENSP00000324172

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Calcium Pump PMCA2 ATPase, Calcium ATPase, Calcium Pump pan PMCA ATPase)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	15765049
GO:0005886	plasma membrane	NAS	1313367
GO:0016021	integral to membrane	IEA	--

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Antibodies for ATP2B2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ATP2B2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Calcium Pump PMCA2 ATPase, Calcium ATPase, Calcium Pump pan PMCA ATPase), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ATP2B2

Assays for ATP2B2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q01814

ProtoNet protein and cluster: Q01814

3 Blocks protein families:

IPB001757 ATPase

IPB006068 Cation transporting ATPase

IPB008250 E1-E2 ATPase-associated region

UniProtKB/Swiss-Prot: AT2B2_HUMAN, Q01814

Similarity: Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ATP2B2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ATP2B2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001001331

Applied Biosystems Silencer® siRNAs for ATP2B2

Sigma-Aldrich siRNA and siRNA Panels for ATP2B2

Sigma-Aldrich shRNA Panels and shRNA for ATP2B2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001001331
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001001331
untagged cDNA clones in CMV expression vector (see all 2): NM_001001331

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001001331

UniProtKB/Swiss-Prot: AT2B2_HUMAN, Q01814

Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the

transport of calcium out of the cell

Catalytic activity: ATP + H(2)O + Ca(2+)(Cis) = ADP + phosphate + Ca(2+)(Trans)

Enzyme Number (IUBMB): EC 3.6.3.8

Genatlas biochemistry entry for ATP2B2:

ATPase,Ca++ transporting,B2 plasma membrane,mediating the extrusion of CA2+ from the cell

7 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Atp2b2):

behavior/neurological	cellular	growth/size	hearing/vestibular/ear	homeostasis/metabolism
nervous system	reproductive system

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0005388	calcium-transporting ATPase activity	NAS	1313367
GO:0005509	calcium ion binding	IEA	--
GO:0005516	calmodulin binding	IEA	--

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ATP2B2 (Your Favorite Gene powered by Ingenuity)

Calcium Signaling

GeneDecks ATP2B2 for the pathways selected above

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5/28 Interacting proteins for ATP2B2 (ENSP00000353414³ Q01814^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP2B4	P23634²	STRING (score=.961) MINT-5203983
Dlg1 Dlg1 (xeno)	Q62696¹^,²	EBI-1174262, EBI-389325 MINT-73074
Dlg2 Dlg2 (xeno)	Q63622¹^,²	EBI-1174262, EBI-396947 MINT-73075
Dlg4 Dlg4 (xeno)	P31016¹^,²	EBI-1174262, EBI-375655 MINT-73073
SLC9A3R2 SLC9A3R2 (xeno)	Q8SQG9¹	EBI-1174262, EBI-1174758

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006754	ATP biosynthetic process	IEA	--
GO:0006812	cation transport	IEA	--
GO:0006816	calcium ion transport	IEA	--
GO:0007605	sensory perception of sound	IMP	15829536
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for ATP2B2

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ATP2B2
1 Novoseek chemical compound relationship for ATP2B2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	42.30	14	19365819 (2), 17208398 (1), 7587388 (1), 17999165 (1) (see all 8)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ATP2B2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ATP2B2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001001331

Sigma-Aldrich siRNA and siRNA Panels for ATP2B2

Sigma-Aldrich shRNA Panels and shRNA for ATP2B2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001001331 NM_001683

REFSEQ mRNAs for ATP2B2 gene (2 alternative transcripts):

NM_001001331.2 NM_001683.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001001331 NM_001683

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001001331
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001001331
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001001331

Additional cDNA sequence:

AB210008.1 AK308898.1 BC019853.1 BC128575.1 DQ201777.1 DQ201778.1 L00620.1 L20977.1

M97260.1 S95738.1 S95743.1 S95758.1 U15688.1 X63575.1

10 DOTS entries:

DT.442590 DT.100746837 DT.101979735 DT.100746836 DT.120861250 DT.40125280 DT.91649950 DT.91725839

DT.92416395 DT.97835031

24/107 AceView cDNA sequences (see all 107 ):

T28048 Z98483 AA363898 AI459315 NM_001683 F07516 NM_001001331 BQ718882

CB156994 BF108567 BX489007 T07949 AA197323 M97260 AL134596 BE701553

BM466549 L00620 AA984150 CK004891 T30695 BM715245 AA324771 AL134595

highest scoring ESTs for ATP2B2:

L20977 X63575 L00620 M97260 AA197252 AA197323 AA324771 AA325402 AA340322 AA363898

Unigene Cluster for ATP2B2:

ATPase, Ca++ transporting, plasma membrane 2

Hs.268942 [show with all ESTs]

Unigene Representative Sequence: NM_001001331

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ATP2B2 (see all 8 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:
SP2:
SP3:											-		-		-
SP4:
SP5:

ExUns:	23	^	24	^	25a	·	25b
SP1:
SP2:
SP3:
SP4:	-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for ATP2B2

6 Ensembl transcripts including schematic representations:

ENST00000397077 ENST00000342354 ENST00000383800 ENST00000360273 ENST00000343816 ENST00000352432

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ATP2B2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ATP2B2

¹ / ² / ³

14 probe-sets matching ATP2B2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37053_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.07	L20977	1.00	1.00	1.00	1
59397_at²^{, 3}	U95-C	1	1.00	1.00	0.98	1.15	T47988	0.40	1.00	0.76	1
41090_s_at²^{, 3}	U95-A	2	1.00	0.97	0.95	0.64	X63575	1.00	1.00	1.00	1
53627_at²^{, 3}	U95-C	1	0.94	1.00	0.91	1.32	AA002211	0.20	1.00	0.72	1
204685_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	R52647	0.60	1.00	0.82	1
234714_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	U15688	0.60	1.00	0.82	1
216120_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X63575	1.00	1.00	1.00	1
211586_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M97260	0.80	1.00	0.91	1
239357_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AA002211	0.20	1.00	0.72	1
204685_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234714_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216120_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211586_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
239357_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks ATP2B2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: GGGTACGTTT

SOURCE GeneReport for Unigene cluster: Hs.268942
Expression variation in blood from EXPOLDB for ATP2B2
UniProtKB/Swiss-Prot: AT2B2_HUMAN, Q01814
Tissue specificity: Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart
muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex
and at low levels in other tissues. Isoforms containing segments X and W are found at low levels
in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal
muscle and heart muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ATP2B2 gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ATP2B4¹	--	ATPase, Ca++ transporting, plasma membrane 4	92.27(n) 97.41(a)	476535 XM_855984.1 XP_861077.1
chimpanzee (Pan troglodytes)	ATP2B2¹	--	ATPase, Ca++ transporting, plasma membrane 2	96.76(n) 96.28(a)	460168 XM_001151685.1 XP_001151685.1
cow (Bos taurus)	ATP2B2¹	--	similar to plasma membrane calcium ATPase 2	93.67(n) 98.79(a)	613800 XM_864933.2 XP_870026.2
rat (Rattus norvegicus)	Atp2b2¹	--	ATPase, Ca++ transporting, plasma membrane 2	91.1(n) 98.75(a)	24215 NM_012508.3 NP_036640.1
mouse (Mus musculus)	Atp2b2^{1, 5}	6 (49.50 cM)⁵	ATPase, Ca++ transporting, plasma membrane 2^{1, 5}	91.76(n)¹ 98.83(a)¹	11941¹ NM_009723.2¹ NP_033853.1¹ AB030737⁵ AB030738⁵ (see all 17)

About this table Species with no ortholog for ATP2B2

ENSEMBL Gene Tree for ATP2B2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ATP2B2 gene

ATP2B1² ATP2B3² ATP2B4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/788 NCBI SNPs in ATP2B2 are shown (see all 788 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 366)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs35674^1,2	A,C,F,H	10343577(+)	`GAGTTC/ATCTGG`	2	--	ut3¹ ese³		8	MN EU EA WA NA	876
	rs1719571^1,2	A,C,F,H	10344180(+)	`AGCTCA/GGATGC`	2	--	ut3¹ ese³		5	MN EU EA WA	596
	rs4327369^1,2	A,C,F,H	10345486(+)	`GGCGAC/GAGGGT`	2	--	ut3¹ ese³		4	EU EA WA	410
	rs714737^1,2	C,F,H,O	10468434(+)	`AAAGAG/AGCCAT`	2	--	ng3¹		20	NA EA EU WA	1778
	rs34867^1,2	A,C,F,H	10467025(-)	`TAAGGA/GTAGTG`	2	--	ng3¹		18	EA NA EU WA	1482
	rs34868^1,2	A,C,F,H	10467703(-)	`TTGGAC/GCTGAG`	2	--	ng3¹		4	EU EA WA	364
	rs40509^1,2	A,C,F,H	10467652(-)	`TCACCA/GTCCTG`	2	--	ng3¹		4	EU EA WA	386
	rs241506^1,2	A,C,F,H	10342604(+)	`CCAAAC/GTAGAA`	2	--	ut3¹ ese³		4	EU EA WA	414
	rs3209637^1,2	C,F,H	10343948(-)	`TGAAAC/TCCTAC`	2	--	ut3¹ ese³		9	MN EU EA WA NA	812
	rs14154^1,2	A,C,F	10343113(+)	`ACATGG/CAGCAT`	2	--	ut3¹ ese³		2	MN	372

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HapMap Linkage Disequilibrium images for ATP2B2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 108733 disorders: 601386

Human Gene Mutation Database: ATP2B2

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/42 PubMed articles for ATP2B2 gene (see all 42 ):

Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region. (PubMed id 1313367)^{2, 3, 4} Heim R.... Carafoli E. (1992)
Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2. (PubMed id 1427863)^{1, 3, 4} Brandt P.... Neve R.L. (1992)
Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. (PubMed id 7989379)^{3, 4} Stauffer T.P....Strehler E.E. (1994)
Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. (PubMed id 8245032)^{3, 4} Stauffer T.P.... Strehler E.E. (1993)
von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region. (PubMed id 8428366)^{3, 4} Latif F.... Lerman M.I. (1993)
Alternative splicing of the first intracellular loop of plasma membrane Ca2+-ATPase isoform 2 alters its membrane targeting. (PubMed id 12624087)^{1, 3} Chicka M.C. and Strehler E.E. (2003)
Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice. (PubMed id 9697703)^{1, 3} Street V.A....Noben-Trauth K. (1998)
Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines. (PubMed id 16216224)^{1, 3} Lee W.J....Monteith G.R. (2005)
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. (PubMed id 19043545)³ Gieger C....Suhre K. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 491	HGNC: 815	AceView: ATP2B2	Ensembl:ENSG00000157087	euGenes: HUgn491
ECgene: ATP2B2	H-InvDB: ATP2B2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ATP2B2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ATP2B2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ATP2B2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ATP2B2		Antibodies for ATP2B2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ATP2B2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (ATP2B2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Calcium Pump PMCA2 ATPase, Calcium ATPase, Calcium Pump pan PMCA ATPase)
	Antibodies (Calcium Pump PMCA2 ATPase, Calcium ATPase, Calcium Pump pan PMCA ATPase)

Search OriGene for ATP2B2

Search Tocris compounds for ATP2B2

	Drugs for ATP2B2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ATP2B2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ATP2B2 Gene at Home site.
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ATP2B2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ATP2B2

Summaries
for ATP2B2

Genomic Location
for ATP2B2

Proteins
for ATP2B2

Protein Domains/
Families
for ATP2B2

Gene Function
for ATP2B2

Pathways & Interactions
for ATP2B2

Drugs & Compounds
for ATP2B2

Transcripts
for ATP2B2

Expression
for ATP2B2

Orthologs
for ATP2B2

Paralogs
for ATP2B2

SNPs/Variants
for ATP2B2

Disorders & Mutations
for ATP2B2

Medical News
for ATP2B2

Publications
for ATP2B2

Search for ATP2B2

Genome Databases showing ATP2B2

Other Databases showing ATP2B2

Specialized Databases showing ATP2B2

Licensable Technologies
for ATP2B2

Services
for ATP2B2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ATP2B2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ATP2B2

Summariesfor ATP2B2

Genomic Locationfor ATP2B2

Proteinsfor ATP2B2

Protein Domains/Familiesfor ATP2B2

Gene Functionfor ATP2B2

Pathways & Interactionsfor ATP2B2

Drugs & Compoundsfor ATP2B2

Transcriptsfor ATP2B2

Expression for ATP2B2

Orthologsfor ATP2B2

Paralogsfor ATP2B2

SNPs/Variantsfor ATP2B2

Disorders & Mutationsfor ATP2B2

Medical Newsfor ATP2B2

Publicationsfor ATP2B2

Search for ATP2B2

Genome Databases showing ATP2B2

Other Databases showing ATP2B2

Specialized Databases showing ATP2B2

Licensable Technologiesfor ATP2B2

Servicesfor ATP2B2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ATP2B2

Summaries
for ATP2B2

Genomic Location
for ATP2B2

Proteins
for ATP2B2

Protein Domains/
Families
for ATP2B2

Gene Function
for ATP2B2

Pathways & Interactions
for ATP2B2

Drugs & Compounds
for ATP2B2

Transcripts
for ATP2B2

Expression
for ATP2B2

Orthologs
for ATP2B2

Paralogs
for ATP2B2

SNPs/Variants
for ATP2B2

Disorders & Mutations
for ATP2B2

Medical News
for ATP2B2

Publications
for ATP2B2

Licensable Technologies
for ATP2B2

Services
for ATP2B2