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Aliases for ATP2B1 Gene

Aliases for ATP2B1 Gene

  • ATPase, Ca++ Transporting, Plasma Membrane 1 2 3
  • PMCA1 3 4 6
  • Plasma Membrane Calcium-Transporting ATPase 1 2 3
  • EC 4 63
  • Plasma Membrane Calcium ATPase Isoform 1 4
  • Plasma Membrane Calcium Pump Isoform 1 4
  • Plasma Membrane Calcium Pump 3
  • EC 3.6.3 63
  • PMCA1kb 3

External Ids for ATP2B1 Gene

Previous GeneCards Identifiers for ATP2B1 Gene

  • GC12M089402
  • GC12M090431
  • GC12M089916
  • GC12M088486
  • GC12M088484
  • GC12M087047
  • GC12M089981

Summaries for ATP2B1 Gene

Entrez Gene Summary for ATP2B1 Gene

  • The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP2B1 Gene

ATP2B1 (ATPase, Ca++ Transporting, Plasma Membrane 1) is a Protein Coding gene. Among its related pathways are CREB Pathway and Platelet homeostasis. GO annotations related to this gene include calmodulin binding and calcium-transporting ATPase activity. An important paralog of this gene is ATP2B3.

UniProtKB/Swiss-Prot for ATP2B1 Gene

  • This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell

Gene Wiki entry for ATP2B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP2B1 Gene

Genomics for ATP2B1 Gene

Regulatory Elements for ATP2B1 Gene

Genomic Location for ATP2B1 Gene

89,588,049 bp from pter
89,709,300 bp from pter
121,252 bases
Minus strand

Genomic View for ATP2B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP2B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP2B1 Gene

Proteins for ATP2B1 Gene

  • Protein details for ATP2B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Plasma membrane calcium-transporting ATPase 1
    Protein Accession:
    Secondary Accessions:
    • Q12992
    • Q12993
    • Q13819
    • Q13820
    • Q13821
    • Q16504
    • Q93082

    Protein attributes for ATP2B1 Gene

    1258 amino acids
    Molecular mass:
    138755 Da
    Quaternary structure:
    • Interacts with PDZD11. Interacts with SLC35G1 and STIM1.

    Alternative splice isoforms for ATP2B1 Gene

neXtProt entry for ATP2B1 Gene

Proteomics data for ATP2B1 Gene at MOPED

Post-translational modifications for ATP2B1 Gene

  • Ubiquitination at Lys19, Lys62, Lys193, Lys256, Lys622, Lys634, Lys806, and Lys1172
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP2B1 Gene

Antibody Products

Domains for ATP2B1 Gene

Gene Families for ATP2B1 Gene

  • PATP :ATPases / P-type

Graphical View of Domain Structure for InterPro Entry



  • P20020
  • The calmodulin-binding subdomain B is different in the different splice variants and shows pH dependent calmodulin binding properties in isoforms A, C, D and E
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
genes like me logo Genes that share domains with ATP2B1: view

Function for ATP2B1 Gene

Molecular function for ATP2B1 Gene

GENATLAS Biochemistry:
ATPase,Ca++ transporting,B1plasma membrane,mediating the extrusion of CA2+ from the cell
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
UniProtKB/Swiss-Prot Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell

Enzyme Numbers (IUBMB) for ATP2B1 Gene

Gene Ontology (GO) - Molecular Function for ATP2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005388 calcium-transporting ATPase activity IEA --
GO:0005515 protein binding IPI 12763866
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATP2B1: view

Phenotypes for ATP2B1 Gene

genes like me logo Genes that share phenotypes with ATP2B1: view

Animal Models for ATP2B1 Gene

MGI Knock Outs for ATP2B1:

Animal Model Products

CRISPR Products

miRNA for ATP2B1 Gene

miRTarBase miRNAs that target ATP2B1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP2B1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ATP2B1 Gene

Localization for ATP2B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP2B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ATP2B1 Gene COMPARTMENTS Subcellular localization image for ATP2B1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
endoplasmic reticulum 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8396145
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ATP2B1: view

Pathways for ATP2B1 Gene

genes like me logo Genes that share pathways with ATP2B1: view

Gene Ontology (GO) - Biological Process for ATP2B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8396145
GO:0007596 blood coagulation TAS --
GO:0008152 metabolic process IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with ATP2B1: view

Compounds for ATP2B1 Gene

(6) HMDB Compounds for ATP2B1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Ca
  • Magnesium
  • NFB Orthophosphate

(3) Novoseek inferred chemical compound relationships for ATP2B1 Gene

Compound -log(P) Hits PubMed IDs
p-mca 92.9 4
calcium 58.6 15
1,25 dihydroxy vitamin d3 41 1
genes like me logo Genes that share compounds with ATP2B1: view

Transcripts for ATP2B1 Gene

Unigene Clusters for ATP2B1 Gene

ATPase, Ca++ transporting, plasma membrane 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP2B1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP2B1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP2: -
SP3: - -
SP4: -
SP5: -

Relevant External Links for ATP2B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP2B1 Gene

mRNA expression in normal human tissues for ATP2B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP2B1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (5.0), Brain - Caudate (basal ganglia) (4.8), Brain - Nucleus accumbens (basal ganglia) (4.1), and Brain - Frontal Cortex (BA9) (4.1).

Protein differential expression in normal tissues for ATP2B1 Gene

This gene is overexpressed in Frontal cortex (17.6) and Brain (15.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP2B1 Gene

SOURCE GeneReport for Unigene cluster for ATP2B1 Gene Hs.506276

mRNA Expression by UniProt/SwissProt for ATP2B1 Gene

Tissue specificity: Isoform B is ubiquitously expressed. Isoform C is found in brain cortex, skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform K has been found in small intestine and liver
genes like me logo Genes that share expressions with ATP2B1: view

Expression partners for ATP2B1 Gene

In Situ Assay Products

Orthologs for ATP2B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP2B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATP2B1 35
  • 95.16 (n)
  • 98.77 (a)
ATP2B1 36
  • 99 (a)
(Canis familiaris)
Mammalia ATP2B1 35
  • 96.15 (n)
  • 99.43 (a)
ATP2B1 36
  • 99 (a)
(Mus musculus)
Mammalia Atp2b1 35
  • 90.79 (n)
  • 99.51 (a)
Atp2b1 16
Atp2b1 36
  • 100 (a)
(Pan troglodytes)
Mammalia ATP2B1 35
  • 99.84 (n)
  • 100 (a)
ATP2B1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Atp2b1 35
  • 88.58 (n)
  • 97.99 (a)
(Monodelphis domestica)
Mammalia ATP2B1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
-- 36
  • 93 (a)
(Gallus gallus)
Aves ATP2B1 35
  • 84.8 (n)
  • 94.68 (a)
ATP2B1 36
  • 91 (a)
(Anolis carolinensis)
Reptilia ATP2B1 36
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25538 35
(Danio rerio)
Actinopterygii atp2b1a 35
  • 73.73 (n)
  • 85.74 (a)
atp2b1a 36
  • 85 (a)
atp2b1b 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK01140 37
  • 63 (a)
  • 59 (a)
(Caenorhabditis elegans)
Secernentea mca-1 37
  • 54 (a)
R05C11.3 37
  • 58 (a)
mca-1 36
  • 51 (a)
mca-2 36
  • 58 (a)
mca-3 36
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PMC1 36
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACA11 35
  • 53.61 (n)
  • 47.72 (a)
(Hordeum vulgare)
Liliopsida Hv.8619 35
(Oryza sativa)
Liliopsida Os12g0136900 35
  • 52.66 (n)
  • 45.4 (a)
(Zea mays)
Liliopsida Zm.17277 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
Species with no ortholog for ATP2B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATP2B1 Gene

Gene Tree for ATP2B1 (if available)
Gene Tree for ATP2B1 (if available)

Paralogs for ATP2B1 Gene

Paralogs for ATP2B1 Gene Pseudogenes for ATP2B1 Gene

genes like me logo Genes that share paralogs with ATP2B1: view

Variants for ATP2B1 Gene

Sequence variations from dbSNP and Humsavar for ATP2B1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs939329 -- 89,646,107(+) CGAGG(A/G)GGAGG intron-variant
rs957525 -- 89,607,038(+) AGTTC(C/T)ATGAT intron-variant
rs988111 -- 89,597,742(-) ACTGA(A/G)AATTC intron-variant
rs1050395 -- 89,635,124(-) AAGGA(A/G)AAACA reference, synonymous-codon
rs1050396 -- 89,635,202(-) ACTGG(G/T)TGGAT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ATP2B1 Gene

Variant ID Type Subtype PubMed ID
nsv832479 CNV Gain 17160897

Relevant External Links for ATP2B1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP2B1 Gene

Disorders for ATP2B1 Gene

(1) University of Copenhagen DISEASES for ATP2B1 Gene

(2) Novoseek inferred disease relationships for ATP2B1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 0 1
cancer 0 1

Relevant External Links for ATP2B1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ATP2B1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for ATP2B1 Gene

Publications for ATP2B1 Gene

  1. Structure of the gene encoding the human plasma membrane calcium pump isoform 1. (PMID: 8396145) Hilfiker H. … Strehler E.E. (J. Biol. Chem. 1993) 3 4 23
  2. Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23. (PMID: 1674727) Olson S. … McBride O.W. (Genomics 1991) 2 3 23
  3. Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique. (PMID: 9020386) Benkwitz C. … Neyses L. (J. Mol. Med. 1997) 3 4
  4. Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump. (PMID: 1332771) Kessler F. … Carafoli E. (Biochemistry 1992) 3 4
  5. Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes. (PMID: 1827443) Wang K.K.W. … Roufogalis B.D. (J. Biol. Chem. 1991) 3 4

Products for ATP2B1 Gene

Sources for ATP2B1 Gene

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