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ATP2B1 Gene

protein-coding GIFtS: 63

GC12M088484

ATPase, Ca++ transporting, plasma membrane 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 3.6.3.8 ^³
PMCA1 ^¹, ², ³, ⁵
PMCA1kb ^²

Descriptions
ATPase, Ca++ transporting, plasma membrane 1 ^²
Plasma membrane calcium ATPase isoform 1 ^³
Plasma membrane calcium pump isoform 1 ^³
plasma membrane calcium ATPase 1 ^²
plasma membrane calcium pump ^²
plasma membrane calcium-ATPase ^²

External Ids
HGNC: 814¹
Entrez Gene: 490²
UniProtKB: P20020³
Ensembl: ENSG00000070961⁷

Search outside databases for aliases for ATP2B1 gene

Previous GC identifers: GC12M089402 GC12M090431 GC12M089916 GC12M088486

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ATP2B1:

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases

characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle.

These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration

gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma

membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of

these enzymes is further increased by alternative splicing of transcripts. The expression of

different isoforms and splice variants is regulated in a developmental, tissue- and cell

type-specific manner, suggesting that these pumps are functionally adapted to the physiological

needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase

isoform 1. Alternatively spliced transcript variants encoding different isoforms have been

identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: AT2B1_HUMAN, P20020

Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the

transport of calcium out of the cell

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ATP2B1 gene

Entrez Gene cytogenetic band: 12q21.3 Ensembl cytogenetic band: 12q21.33 HGNC cytogenetic band: 12q21-q23

ATP2B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M088484: (about GC identifiers)

Start:	88,505,957 bp from pter
End:	88,573,975 bp from pter
Size:	68,019 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_019546.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AT2B1_HUMAN, P20020 (See protein sequence)

Recommended Name: Plasma membrane calcium-transporting ATPase 1

Size: 1258 amino acids; 138755 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q12992 Q12993 Q13819 Q13820 Q13821 Q16504 Q93082

Alternative splicing: 6 isoforms: P20020-1 P20020-2 P20020-3 P20020-4 P20020-5 P20020-6

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001001323.1 NP_001673.2

ENSEMBL proteins:

ENSP00000376869 ENSP00000352054 ENSP00000261173 ENSP00000343599

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Calcium ATPase, PMCA1, Calcium Pump pan PMCA ATPase)
	Human Recombinant Proteins from Abnova (ATP2B1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8396145

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Antibodies for ATP2B1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ATP2B1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Calcium ATPase, PMCA1, Calcium Pump pan PMCA ATPase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ATP2B1)
	Novus Biologicals Antibodies for ATP2B1

Assays for ATP2B1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P20020

ProtoNet protein and cluster: P20020

3 Blocks protein families:

IPB001757 ATPase

IPB006068 Cation transporting ATPase

IPB008250 E1-E2 ATPase-associated region

UniProtKB/Swiss-Prot: AT2B1_HUMAN, P20020

Domain: The calmodulin-binding subdomain B is different in the different splice variants and shows

pH dependent calmodulin binding properties in isoforms A, C, D and E

Similarity: Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ATP2B1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ATP2B1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001001323

Applied Biosystems Silencer® siRNAs for ATP2B1

Sigma-Aldrich siRNA and siRNA Panels for ATP2B1

Sigma-Aldrich shRNA Panels and shRNA for ATP2B1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001001323
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001001323
untagged cDNA clones in CMV expression vector (see all 2): NM_001001323

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001682

UniProtKB/Swiss-Prot: AT2B1_HUMAN, P20020

Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the

transport of calcium out of the cell

Catalytic activity: ATP + H(2)O + Ca(2+)(Cis) = ADP + phosphate + Ca(2+)(Trans)

Enzyme Number (IUBMB): EC 3.6.3.8

Genatlas biochemistry entry for ATP2B1:

ATPase,Ca++ transporting,B1plasma membrane,mediating the extrusion of CA2+ from the cell

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atp2b1):

lethality-prenatal/perinatal

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0005388	calcium-transporting ATPase activity	TAS	8396145
GO:0005509	calcium ion binding	IEA	--
GO:0005516	calmodulin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ATP2B1 (Your Favorite Gene powered by Ingenuity)

Calcium Signaling

GeneDecks ATP2B1 for the pathways selected above

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5/23 Interacting proteins for ATP2B1 (ENSP00000352054³ P20020²) via UniProtKB, MINT, and/or STRING (see all 23 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCR	P11274²	MINT-69534
CALM3	ENSP00000291295³	STRING (score=.956)
MYB	ENSP00000339992³	STRING (score=.916)
ATP2B3	ENSP00000343886³	STRING (score=.904)
CABP2	ENSP00000294288³	STRING (score=.899)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006754	ATP biosynthetic process	IEA	--
GO:0006812	cation transport	IEA	--
GO:0006816	calcium ion transport	IEA	--
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for ATP2B1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ATP2B1
3 Novoseek chemical compound relationships for ATP2B1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
p-mca	93.12	4	8700162 (1), 16452157 (1), 16328033 (1), 12359307 (1)
calcium	58.17	16	17669706 (2), 7554945 (1), 7501994 (1), 11062020 (1) (see all 11)
1,25 dihydroxy vitamin d3	43.15	1	11277270 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ATP2B1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ATP2B1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001001323

Sigma-Aldrich siRNA and siRNA Panels for ATP2B1

Sigma-Aldrich shRNA Panels and shRNA for ATP2B1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001001323 NM_001682

REFSEQ mRNAs for ATP2B1 gene (2 alternative transcripts):

NM_001001323.1 NM_001682.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001001323 NM_001682

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001001323
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001001323
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001001323

Additional cDNA sequence:

AB208896.1 AF070606.1 AK024895.1 AK027053.1 AK308723.1 AY740526.1 BC015346.1 CR598557.1

CR624114.1 DQ201776.1 J04027.1 M95541.1 S49852.1 U15686.1 U15687.1

9 DOTS entries:

DT.316081 DT.100773335 DT.91761431 DT.100773334 DT.91818069 DT.92059953 DT.100810094 DT.95230337

DT.91891941

24/295 AceView cDNA sequences (see all 295 ):

BQ776639 BM455624 M95541 BU618992 BM974301 AW873040 CB242007 AW439527

CA446744 AI865601 BF432072 BQ776185 BQ948286 BQ002401 AI865462 AA731599

CB159965 CB069114 AW169755 AI859270 J04027 H19799 U15686 AW613371

highest scoring ESTs for ATP2B1:

J04027 AF070606 AI337321 BC015346 BQ310789 M95541 AA025218 AA026006 AA041264 AA041498

Unigene Cluster for ATP2B1:

ATPase, Ca++ transporting, plasma membrane 1

Hs.506276 [show with all ESTs]

Unigene Representative Sequence: NM_001001323

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ATP2B1 (see all 7 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20
SP1:
SP2:																																																	-
SP3:																																													-				-
SP4:							-
SP5:																									-

About this scheme

ECgene alternative splicing isoforms for ATP2B1

4 Ensembl transcripts including schematic representations:

ENST00000393164 ENST00000359142 ENST00000261173 ENST00000348959

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ATP2B1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ATP2B1

¹ / ² / ³

9 probe-sets matching ATP2B1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37661_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.90	J04027	1.00	1.00	1.00	1
34188_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.84	AF070606	0.80	1.00	0.91	1
61289_at²^{, 3}	U95-C	1	1.00	1.00	0.94	1.27	AI337321	0.80	1.00	0.91	1
212930_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW576457	0.60	1.00	0.82	1
209281_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M95541	0.80	1.00	0.91	1
215716_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212930_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209281_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215716_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ATP2B1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: TAATGGAAGG

SOURCE GeneReport for Unigene cluster: Hs.506276
Expression variation in blood from EXPOLDB for ATP2B1
UniProtKB/Swiss-Prot: AT2B1_HUMAN, P20020
Tissue specificity: Isoform B is ubiquitously expressed. Isoform c is found in brain cortex,
skeletal muscle and heart muscle. Isoform D has only been found in fetal skeletal muscle. Isoform
k has been found in small intestine and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ATP2B1 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ATP2B1¹	--	ATPase, Ca++ transporting, plasma membrane 1	94.91(n) 98(a)	403480 XM_860630.1 XP_865723.1
cow (Bos taurus)	ATP2B1¹	--	ATPase, Ca++ transporting, plasma membrane 1	95.16(n) 98.77(a)	282641 NM_174696.2 NP_777121.1
rat (Rattus norvegicus)	Atp2b1¹	--	ATPase, Ca++ transporting, plasma membrane 1	88.58(n) 97.99(a)	29598 NM_053311.1 NP_445763.1
mouse (Mus musculus)	Atp2b1^{1, 5}	10⁵	ATPase, Ca++ transporting, plasma membrane 1^{1, 5}	90.79(n)¹ 99.51(a)¹	67972¹ NM_026482.1¹ NP_080758.1¹ AI849350⁵ AK013291⁵ (see all 26)
chicken (Gallus gallus)	ATP2B1¹	--	ATPase, Ca++ transporting, plasma membrane 1	85.11(n) 95.07(a)	374244 XM_416133.2 XP_416133.2

About this table Species with no ortholog for ATP2B1

ENSEMBL Gene Tree for ATP2B1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ATP2B1 gene

ATP2B2² ATP2B3² ATP2B4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/318 NCBI SNPs in ATP2B1 are shown (see all 318 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 130)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs10858915^1,2	A,C,F,H	88575678(+)	`CTAGGG/AAGCAC`	2	--	ng3¹		4	EU EA WA	418
	rs12579302^1,2	C,F,H	88574634(+)	`ACTCTA/GTATGA`	2	--	ng3¹		4	EU EA WA	410
	rs11105359^1,2	C,F,H	88575212(+)	`CCCTTG/TGTTCT`	2	--	ng3¹		4	EU EA WA	408
	rs11105360^1,2	C,F,H	88575303(+)	`CTAAAT/CCTAAA`	2	--	ng3¹		8	EU EA WA	838
	rs2681477^1,2	H	88505610(-)	`TTATCT/AGAACT`	2	--	ng5¹		4	EU EA WA	418
	rs1050395^1,2	C,F,H,O	88553032(-)	`AAGGAA/GAAACA`	2	E/E	syn¹		9	MN NA EU EA WA	729
	rs11105347^1,2	C,F,H	88544516(+)	`TCCTGG/TGCTTT`	2	A/A	syn¹ ese³		5	EU EA WA NA	490
	rs35349730^1,2	F	88522150(+)	`CTGTCA/GTAGAC`	2	Y/Y	syn¹		1	NA	78
	rs35414385^1,2	F	88534725(+)	`ACAGGA/GTCTTC`	2	D/D	syn¹		1	NA	78
	rs1401982^1,2	A,C,F,H,O	88513730(-)	`GTTATT/CCAGGG`	2	--	int¹		18	NA EA MN EU WA	1672

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HapMap Linkage Disequilibrium images for ATP2B1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 108731

2 Novoseek disease relationships for ATP2B1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0.00	1	16328033 (1)
breast cancer	0.00	1	12359307 (1)

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Human Genome Epidemiology Navigator: ATP2B1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/64 PubMed articles for ATP2B1 gene (see all 64 ):

Structure of the gene encoding the human plasma membrane calcium pump isoform 1. (PubMed id 8396145)^{1, 3, 4} Hilfiker H....Strehler E.E. (1993)
Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23. (PubMed id 1674727)^{1, 2, 3} Olson S....McBride O.W. (1991)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique. (PubMed id 9020386)^{3, 4} Benkwitz C.... Neyses L. (1997)
Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. (PubMed id 7989379)^{3, 4} Stauffer T.P....Strehler E.E. (1994)
Human and rat intestinal plasma membrane calcium pump isoforms. (PubMed id 7694502)^{3, 4} Howard A.... Walters J.R. (1993)
Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes. (PubMed id 8245032)^{3, 4} Stauffer T.P.... Strehler E.E. (1993)
Molecular cloning of a plasma membrane calcium pump from human osteoblasts. (PubMed id 8386431)^{3, 4} Kumar R.... Penniston J.T. (1993)
Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump. (PubMed id 1332771)^{3, 4} Kessler F.... Carafoli E. (1992)
Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes. (PubMed id 1827443)^{3, 4} Wang K.K.W....Roufogalis B.D. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 490	HGNC: 814	AceView: ATP2B1	Ensembl:ENSG00000070961	euGenes: HUgn490
ECgene: ATP2B1	H-InvDB: ATP2B1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ATP2B1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ATP2B1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ATP2B1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ATP2B1		Antibodies for ATP2B1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ATP2B1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ATP2B1)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (Calcium ATPase, PMCA1, Calcium Pump pan PMCA ATPase)

Search OriGene for ATP2B1

Search Tocris compounds for ATP2B1

	Drugs for ATP2B1
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Antibodies for ATP2B1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ATP2B1 Gene at Home site.
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ATP2B1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ATP2B1

Summaries
for ATP2B1

Genomic Location
for ATP2B1

Proteins
for ATP2B1

Protein Domains/
Families
for ATP2B1

Gene Function
for ATP2B1

Pathways & Interactions
for ATP2B1

Drugs & Compounds
for ATP2B1

Transcripts
for ATP2B1

Expression
for ATP2B1

Orthologs
for ATP2B1

Paralogs
for ATP2B1

SNPs/Variants
for ATP2B1

Disorders & Mutations
for ATP2B1

Medical News
for ATP2B1

Publications
for ATP2B1

Search for ATP2B1

Genome Databases showing ATP2B1

Other Databases showing ATP2B1

Specialized Databases showing ATP2B1

Licensable Technologies
for ATP2B1

Services
for ATP2B1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ATP2B1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ATP2B1

Summariesfor ATP2B1

Genomic Locationfor ATP2B1

Proteinsfor ATP2B1

Protein Domains/Familiesfor ATP2B1

Gene Functionfor ATP2B1

Pathways & Interactionsfor ATP2B1

Drugs & Compoundsfor ATP2B1

Transcriptsfor ATP2B1

Expression for ATP2B1

Orthologsfor ATP2B1

Paralogsfor ATP2B1

SNPs/Variantsfor ATP2B1

Disorders & Mutationsfor ATP2B1

Medical Newsfor ATP2B1

Publicationsfor ATP2B1

Search for ATP2B1

Genome Databases showing ATP2B1

Other Databases showing ATP2B1

Specialized Databases showing ATP2B1

Licensable Technologiesfor ATP2B1

Servicesfor ATP2B1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ATP2B1

Summaries
for ATP2B1

Genomic Location
for ATP2B1

Proteins
for ATP2B1

Protein Domains/
Families
for ATP2B1

Gene Function
for ATP2B1

Pathways & Interactions
for ATP2B1

Drugs & Compounds
for ATP2B1

Transcripts
for ATP2B1

Expression
for ATP2B1

Orthologs
for ATP2B1

Paralogs
for ATP2B1

SNPs/Variants
for ATP2B1

Disorders & Mutations
for ATP2B1

Medical News
for ATP2B1

Publications
for ATP2B1

Licensable Technologies
for ATP2B1

Services
for ATP2B1