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Aliases for ATP23 Gene

Aliases for ATP23 Gene

  • ATP23 Metallopeptidase And ATP Synthase Assembly Factor Homolog (S. Cerevisiae) 2 3
  • XRCC6 Binding Protein 1 2 3 5
  • XRCC6BP1 3 4 5
  • XRCC6-Binding Protein 1 3 4
  • Ku70 Binding Protein 3 2 3
  • Ku70-Binding Protein 3 3 4
  • KUB3 3 4
  • EC 3.4.24.- 4
  • EC 3.4.24 63

External Ids for ATP23 Gene

Previous HGNC Symbols for ATP23 Gene

  • XRCC6BP1

Summaries for ATP23 Gene

Entrez Gene Summary for ATP23 Gene

  • The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for ATP23 Gene

ATP23 (ATP23 Metallopeptidase And ATP Synthase Assembly Factor Homolog (S. Cerevisiae)) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP23 Gene

Genomics for ATP23 Gene

Regulatory Elements for ATP23 Gene

Enhancers for ATP23 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP23 on UCSC Golden Path with GeneCards custom track

Promoters for ATP23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP23 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP23 Gene

Chromosome:
12
Start:
57,941,541 bp from pter
End:
57,957,269 bp from pter
Size:
15,729 bases
Orientation:
Plus strand

Genomic View for ATP23 Gene

Genes around ATP23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP23 Gene

Proteins for ATP23 Gene

  • Protein details for ATP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6H3-ATP23_HUMAN
    Recommended name:
    Mitochondrial inner membrane protease ATP23 homolog
    Protein Accession:
    Q9Y6H3
    Secondary Accessions:
    • Q1RLM4
    • Q96E81

    Protein attributes for ATP23 Gene

    Size:
    246 amino acids
    Molecular mass:
    28081 Da
    Quaternary structure:
    • Interacts with XRCC6.
    SequenceCaution:
    • Sequence=AAD31085.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ATP23 Gene

Proteomics data for ATP23 Gene at MOPED

Selected DME Specific Peptides for ATP23 Gene

Post-translational modifications for ATP23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP23 Gene

Domains & Families for ATP23 Gene

Protein Domains for ATP23 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATP23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6H3

UniProtKB/Swiss-Prot:

ATP23_HUMAN :
  • Belongs to the peptidase M76 family.
Family:
  • Belongs to the peptidase M76 family.
genes like me logo Genes that share domains with ATP23: view

No data available for Gene Families for ATP23 Gene

Function for ATP23 Gene

Enzyme Numbers (IUBMB) for ATP23 Gene

genes like me logo Genes that share phenotypes with ATP23: view

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATP23 Gene

Localization for ATP23 Gene

Gene Ontology (GO) - Cellular Components for ATP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ATP23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for ATP23 Gene

Pathways & Interactions for ATP23 Gene

SuperPathways for ATP23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 10219089
genes like me logo Genes that share ontologies with ATP23: view

No data available for Pathways by source and SIGNOR curated interactions for ATP23 Gene

Drugs & Compounds for ATP23 Gene

No Compound Related Data Available

Transcripts for ATP23 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ATP23 Gene

No ASD Table

Relevant External Links for ATP23 Gene

GeneLoc Exon Structure for
ATP23
ECgene alternative splicing isoforms for
ATP23

Expression for ATP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with ATP23: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ATP23 Gene

Orthologs for ATP23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia XRCC6BP1 35
  • 89.16 (n)
  • 90.24 (a)
XRCC6BP1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia XRCC6BP1 35
  • 90.62 (n)
  • 88.84 (a)
XRCC6BP1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Xrcc6bp1 35
  • 79.95 (n)
  • 80.49 (a)
Xrcc6bp1 16
Xrcc6bp1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia XRCC6BP1 35
  • 99.19 (n)
  • 98.78 (a)
XRCC6BP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Xrcc6bp1 35
  • 79.27 (n)
  • 79.67 (a)
oppossum
(Monodelphis domestica)
Mammalia XRCC6BP1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia XRCC6BP1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves XRCC6BP1 35
  • 70.96 (n)
  • 66.09 (a)
XRCC6BP1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia XRCC6BP1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16237 35
xrcc6bp1 35
  • 72.15 (n)
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia kub3-prov 35
zebrafish
(Danio rerio)
Actinopterygii xrcc6bp1 35
  • 64.57 (n)
  • 65.69 (a)
xrcc6bp1 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009567 35
  • 51.3 (n)
  • 43.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5131 35
  • 52.64 (n)
  • 45.9 (a)
CG5131 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATP23 36
  • 26 (a)
OneToOne
ATP23 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03420 35
  • 52.52 (n)
  • 41.86 (a)
rice
(Oryza sativa)
Liliopsida Os12g0288900 35
  • 47.22 (n)
  • 40.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atp23 35
  • 50.67 (n)
  • 39.31 (a)
Species with no ortholog for ATP23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP23 Gene

ENSEMBL:
Gene Tree for ATP23 (if available)
TreeFam:
Gene Tree for ATP23 (if available)

Paralogs for ATP23 Gene

No data available for Paralogs for ATP23 Gene

Variants for ATP23 Gene

Sequence variations from dbSNP and Humsavar for ATP23 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7133275 -- 57,942,320(+) AACCT(A/G)CCGTT intron-variant
rs7133278 -- 57,942,283(+) CATAC(A/C)AAGGC intron-variant
rs10122 -- 57,956,848(+) GCTCA(C/T)AGAGA reference, synonymous-codon
rs7135674 -- 57,953,793(+) AACTT(C/T)GTATG intron-variant
rs7136078 -- 57,947,939(+) ATTTT(A/G)TATGT intron-variant

Variation tolerance for ATP23 Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.82; 73.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ATP23 Gene

Disorders for ATP23 Gene

Relevant External Links for ATP23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP23

No disorders were found for ATP23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP23 Gene

Publications for ATP23 Gene

  1. Isolation of Ku70-binding proteins (KUBs). (PMID: 10219089) Yang C.-R. … Boothman D.A. (Nucleic Acids Res. 1999) 2 3 4 67
  2. The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase. (PMID: 17135290) Zeng X. … Tzagoloff A. (Mol. Biol. Cell 2007) 2 3
  3. KUB3 amplification and overexpression in human gliomas. (PMID: 11571779) Fischer U. … Meese E. (Glia 2001) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ATP23 Gene

Sources for ATP23 Gene

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