Aliases for ATP1B4 Gene
- ATPase Na+/K+ Transporting Family Member Beta 4 2 3 5
- ATPase, Na+/K+ Transporting, Beta 4 Polypeptide 2 3
- X/Potassium-Transporting ATPase Subunit Beta-M 3 4
- Na,K-ATPase Beta M-Subunit 2 3
- BetaM 2 3
- ATPase, (Na+)/K+ Transporting, Beta 4 Polypeptide 2
- X,K-ATPase Beta-M Subunit 3
- X,K-ATPase Subunit Beta-M 4
- Protein ATP1B4 3
External Ids for ATP1B4 Gene
Previous GeneCards Identifiers for ATP1B4 Gene
This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
GeneCards Summary for ATP1B4 Gene
ATP1B4 (ATPase Na+/K+ Transporting Family Member Beta 4) is a Protein Coding gene. Diseases associated with ATP1B4 include Kufor-Rakeb Syndrome and Thyrotoxic Periodic Paralysis. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Insulin secretion. GO annotations related to this gene include monovalent inorganic cation transmembrane transporter activity. An important paralog of this gene is ATP1B2.
UniProtKB/Swiss-Prot for ATP1B4 Gene
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit.
The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.