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ATP1B4 Gene

protein-coding   GIFtS: 53
GCID: GC0XP119495

ATPase, Na+/K+ Transporting, Beta 4 Polypeptide

(Previous names: ATPase, (Na+)/K+ transporting, beta 4 polypeptide)
  See ATP1B4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase, Na+/K+ Transporting, Beta 4 Polypeptide1 2     Na,K-ATPase Beta M-Subunit2
X/Potassium-Transporting ATPase Subunit Beta-M2 3     Protein ATP1B42
Na1     X,K-ATPase Beta-M Subunit2
ATPase, (Na+)/K+ Transporting, Beta 4 Polypeptide1     X,K-ATPase Subunit Beta-M3
K-ATPase Beta M-Subunit1     

External Ids:    HGNC: 8081   Entrez Gene: 234392   Ensembl: ENSG000001018927   UniProtKB: Q9UN423   

Export aliases for ATP1B4 gene to outside databases

Previous GC identifers: GC0XP114313 GC0XP116481 GC0XP117471 GC0XP118250 GC0XP119277 GC0XP119379 GC0XP108947


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATP1B4 Gene:
This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in
function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species,
this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein
interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta
signaling. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Mar 2010)

GeneCards Summary for ATP1B4 Gene:
ATP1B4 (ATPase, Na+/K+ transporting, beta 4 polypeptide) is a protein-coding gene. Diseases associated with ATP1B4 include thyrotoxic periodic paralysis. GO annotations related to this gene include monovalent inorganic cation transmembrane transporter activity. An important paralog of this gene is ATP1B1.

UniProtKB/Swiss-Prot: AT1B4_HUMAN, Q9UN42
Function: May act as a transcriptional coregulator during muscle development through its interaction with SNW1.
Has lost its ancestral function as a Na,K-ATPase beta-subunit

summary for ATP1B4 Gene:
Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients
across the plasma membrane.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP1B4 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   ARP-1   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP1B4 promoter sequence
   Search Chromatin IP Primers for ATP1B4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP1B4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

ATP1B4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP1B4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP119495:  view genomic region     (about GC identifiers)

Start:
119,495,940 bp from pter      End:
119,517,104 bp from pter
Size:
21,165 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AT1B4_HUMAN, Q9UN42 (See protein sequence)
Recommended Name: Protein ATP1B4  
Size: 357 amino acids; 41598 Da
Subunit: Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1 (By similarity).
According to PubMed:17592128, does not associate with known Na,K-ATPase alpha-subunits
Secondary accessions: Q17RR0 Q9UN41
Alternative splicing: 2 isoforms:  Q9UN42-1   Q9UN42-2   

Explore the universe of human proteins at neXtProt for ATP1B4: NX_Q9UN42

Explore proteomics data for ATP1B4 at MOPED


See ATP1B4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001135919.1  NP_036201.1  

ENSEMBL proteins: 
 ENSP00000218008   ENSP00000355346   ENSP00000443334  

ATP1B4 Human Recombinant Protein Products:

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Novus Biologicals ATP1B4 Protein
Novus Biologicals ATP1B4 Lysate
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Browse Proteins at Cloud-Clone Corp.

 
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antibodies-online proteins for ATP1B4 

 
antibodies-online peptides for ATP1B4

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antibodies-online antibodies for ATP1B4 (5 products) 

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antibodies-online kits for ATP1B4 (16 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PATP: ATPases / P-type

1 InterPro protein domain:
 IPR000402 Na/K_ATPase_sub_beta

Graphical View of Domain Structure for InterPro Entry Q9UN42

ProtoNet protein and cluster: Q9UN42

1 Blocks protein domain: IPB000402 Na+/K+ ATPase

UniProtKB/Swiss-Prot: AT1B4_HUMAN, Q9UN42
Similarity: Belongs to the X(+)/potassium ATPases subunit beta family


Find genes that share domains with ATP1B4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AT1B4_HUMAN, Q9UN42
Function: May act as a transcriptional coregulator during muscle development through its interaction with SNW1.
Has lost its ancestral function as a Na,K-ATPase beta-subunit

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0015077monovalent inorganic cation transmembrane transporter activity TAS10456317
     
Find genes that share ontologies with ATP1B4           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ATP1B4

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat ATP1B4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ATP1B4 (see all 83):
hsa-miR-4254 hsa-miR-640 hsa-miR-631 hsa-miR-199a-3p hsa-miR-15a hsa-miR-3138 hsa-miR-3653 hsa-miR-519a
SwitchGear 3'UTR luciferase reporter plasmidATP1B4 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for ATP1B4
Predesigned siRNA for gene silencing in human, mouse, rat ATP1B4

Gene Editing
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DNA2.0 Custom Protein Engineering Service for ATP1B4

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GenScript: all cDNA clones in your preferred vector (see all 2): ATP1B4 (NM_001142447)
Sino Biological Human cDNA Clone for ATP1B4
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP1B4

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP1B4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AT1B4_HUMAN, Q9UN42: Nucleus inner membrane; Single-pass type II membrane protein (By similarity). Note=Detected
in nuclear envelops
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
plasma membrane4
mitochondrion2
cytosol1
endoplasmic reticulum1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ----
GO:0005637nuclear inner membrane IDA17592128
GO:0005887integral component of plasma membrane TAS10456317
GO:0005890sodium:potassium-exchanging ATPase complex IEA--

Find genes that share ontologies with ATP1B4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ATP1B4 About   (see all 15)  
See pathways by source

SuperPathContained pathways About
1Insulin secretion
Insulin secretion0.36
Thyroid hormone synthesis0.36
2Salivary secretion
Salivary secretion0.34
Gastric acid secretion0.34
3Neuropathic Pain-Signaling in Dorsal Horn Neurons
Aldosterone Signaling in Epithelial Cells0.47
4Hepatic ABC Transporters
Hepatic ABC Transporters0.41
5Thyroid hormone signaling pathway
Thyroid hormone signaling pathway


Find genes that share SuperPaths with ATP1B4           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATP1B4
    Hepatic ABC Transporters
Aldosterone Signaling in Epithelial Cells



Selected Kegg Pathways  (Kegg details for ATP1B4) (see all 15):
    Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Insulin secretion
Thyroid hormone synthesis
Thyroid hormone signaling pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATP1B4
Interactions:

    Search GeneGlobe Interaction Network for ATP1B4

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for ATP1B4 (ENSP000002180084) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
BACE1ENSP000003185854STRING: ENSP00000318585
ATP1A1ENSP000002955984STRING: ENSP00000295598
ATP1A2ENSP000003544904STRING: ENSP00000354490
ATP1A4ENSP000003570604STRING: ENSP00000357060
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IDA17592128
GO:0006810transport TAS10456317
GO:0006813potassium ion transport ----
GO:0006814sodium ion transport ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for ATP1B4 available from Tocris Bioscience    About this table
CompoundAction CAS #
Lithium carbonateMood stabilizer; inhibits Na+/K+ ATPase pump activity[554-13-2]
Digoxin Na+, K+-ATPase inhibitor [20830-75-5]

8 HMDB Compounds for ATP1B4    About this table
CompoundSynonyms CAS #PubMed Ids
ADPadenosindiphosphorsaeure (see all 8)58-64-0--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Clotrimazole(Chlorotrityl)imidazole (see all 72)23593-75-1--
MagnesiumMagnesium (see all 2)7439-95-4--
PhosphateNFB Orthophosphate (see all 13)14265-44-2--
PotassiumK+ (see all 16)7440-09-7--
SodiumSodium (see all 2)7440-23-5--
WaterDihydrogen oxide (see all 2)7732-18-5--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ATP1B4 gene (2 alternative transcripts): 
NM_001142447.2  NM_012069.4  

Unigene Cluster for ATP1B4:

ATPase, Na+/K+ transporting, beta 4 polypeptide
Hs.292599  [show with all ESTs]
Unigene Representative Sequence: NM_001142447
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000218008(uc004esr.3 uc011mty.2) ENST00000361319(uc004esq.3 uc011mtx.2)
ENST00000539306
miRNA
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hsa-miR-4254 hsa-miR-640 hsa-miR-631 hsa-miR-199a-3p hsa-miR-15a hsa-miR-3138 hsa-miR-3653 hsa-miR-519a
SwitchGear 3'UTR luciferase reporter plasmidATP1B4 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat ATP1B4
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GenScript: all cDNA clones in your preferred vector (see all 2): ATP1B4 (NM_001142447)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP1B4
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for ATP1B4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATP1B4
  QuantiTect SYBR Green Assays in human, mouse, rat ATP1B4
  QuantiFast Probe-based Assays in human, mouse, rat ATP1B4

Additional mRNA sequence: 

AF158383.2 AF158384.2 AK309999.1 BC117227.1 BC143404.1 

3 DOTS entries:

DT.442571  DT.40290196  DT.95242280 

20 AceView cDNA sequences:

AA490116 NM_012069 AI038498 AI659245 AA780676 AF158383 AI800759 AF158384 
AI082610 AI379223 AA807866 AA436959 BX114136 CD624146 AA504702 CD624147 
BF577155 AI338891 AW970986 AA516350 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ATP1B4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAAACATACT
ATP1B4 Expression
About this image


ATP1B4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Skeletal Muscle (Muscoskeletal System)
ATP1B4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ATP1B4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.292599

UniProtKB/Swiss-Prot: AT1B4_HUMAN, Q9UN42
Tissue specificity: Highly expressed in skeletal muscle and at a lower level in heart

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP1B4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ATP1B4 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Atp1b41 , 5 ATPase, (Na+)/K+ transporting, beta 4 polypeptide1, 5 89.51(n)1
89.04(a)1
  X (22.58 cM)5
678211  NM_133690.21  NP_598451.11 
 383161845 
chicken
(Gallus gallus)
Aves ATP1B41 ATPase, Na+/K+ transporting, beta 4 polypeptide 67.63(n)
62.82(a)
  422365  NM_001044651.1  NP_001038116.1 
lizard
(Anolis carolinensis)
Reptilia ATP1B46
ATPase, Na+/K+ transporting, beta 4 polypeptide
50(a)
1 ↔ 1
GL343950.1(3323-24028)
tropical clawed frog
(Xenopus tropicalis)
Amphibia atp1b41 ATPase, Na+/K+ transporting, beta 4 polypeptide 59.49(n)
55.11(a)
  100490400  XM_002931802.2  XP_002931848.1 
zebrafish
(Danio rerio)
Actinopterygii atp1b41 ATPase, (Na+)/K+ transporting, beta 4 polypeptide 56.7(n)
48.34(a)
  100037383  XM_002664424.3  XP_002664470.2 
fruit fly
(Drosophila melanogaster)
Insecta nrv16
nrv36
(see all 3)
nervana 3
(see all 3)
29(a)
24(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
2L(6778555-6786861)
2L(21380000-21393319)
worm
(Caenorhabditis elegans)
Secernentea nkb-16
nkb-36
Protein NKB-3 (nkb-3) mRNA, complete cds
24(a)
23(a)
many ↔ many
many ↔ many
I(9431249-9433811) WBGene00007646
X(13765353-13770558) WBGene00010117


ENSEMBL Gene Tree for ATP1B4 (if available)
TreeFam Gene Tree for ATP1B4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ATP1B4 gene
ATP1B12  ATP1B32  ATP1B22  ATP4B2  
4 SIMAP similar genes for ATP1B4 using alignment to 4 protein entries:     AT1B4_HUMAN (see all proteins):
ATP1B2    ATP1B3    ATP4B    ATP1B1

Find genes that share paralogs with ATP1B4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ATP1B4 (see all 380)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs38107481,2
C,F,A,H--119488024(-) GGGCAT/CATTAT 2 -- us2k122Minor allele frequency- C:0.40NS EA NA WA CSA 2377
rs38107471,2
C,F,H--119488087(-) AGTGGC/ATACAA 2 -- us2k1 tfbs313Minor allele frequency- A:0.13NS EA NA 1874
rs1498449821,2
C--119488119(+) GCCACC/TTGTGG 2 -- us2k10--------
rs38107461,2
C,F,A,H--119488290(-) TTCTGG/CAATGT 2 -- us2k114Minor allele frequency- C:0.17NS EA NA WA 1965
rs1404843731,2
--119488303(+) CAGCCC/TGGGCT 2 -- us2k10--------
rs341853161,2
C--119488449(+) CCCTAC/TTCTCA 2 -- us2k10--------
rs1442352651,2
C--119488460(+) GTTTTC/TGAAAT 2 -- us2k10--------
rs1899343841,2
--119488579(+) TCACAC/GAAAAG 2 -- us2k10--------
rs1825700871,2
--119488908(+) AATGTA/GCCCAG 2 -- us2k10--------
rs350414251,2
C,F--119489033(+) ACCCCG/AAACAG 2 -- us2k11Minor allele frequency- A:0.00NA 2

HapMap Linkage Disequilibrium report for ATP1B4 (119495940 - 119517104 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ATP1B4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv528786CNV Gain19592680
dgv2470e1CNV Complex17122850

Human Gene Mutation Database (HGMD): ATP1B4
Locus Specific Mutation Databases (LSDB): ATP1B4

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ATP1B4
DNA2.0 Custom Variant and Variant Library Synthesis for ATP1B4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for ATP1B4:    
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thyrotoxic periodic paralysis


Find genes that share disorders with ATP1B4           About GenesLikeMe

Genetic Association Database (GAD): ATP1B4
Human Genome Epidemiology (HuGE) Navigator: ATP1B4 (1 document)

Export disorders for ATP1B4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ATP1B4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ATP1B4)
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world of online information

  1. Evolution of Na,K-ATPase betam-subunit into a coregulator of transcription in placental mammals. (PubMed id 17592128)1, 2, 3 Pestov N.B.... Modyanov N.N. (Proc. Natl. Acad. Sci. U.S.A. 2007)
  2. Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles. (PubMed id 10456317)1, 2, 3 Pestov N.B.... Modyanov N.N. (FEBS Lett. 1999)
  3. Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes. (PubMed id 16430714)1, 4 Kung A.W....Chan V. (Clin. Endocrinol. (Oxf) 2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Accumulation of beta (m), a structural member of X,K-ATPase beta- subunit family, in nuclear envelopes of perinatal myocytes. (PubMed id 14656723)2, 9 Zhao H....Modyanov N.N. (Am. J. Physiol. 2004)
  6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23439 HGNC: 808 AceView: ATP1B4 Ensembl:ENSG00000101892 euGenes: HUgn23439
ECgene: ATP1B4 Kegg: 23439 H-InvDB: ATP1B4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ATP1B4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ATP1B4 gene:
Search GeneIP for patents involving ATP1B4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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