Aliases for ATP1B4 Gene
External Ids for ATP1B4 Gene
This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
GeneCards Summary for ATP1B4 Gene
ATP1B4 (ATPase, Na+/K+ Transporting, Beta 4 Polypeptide) is a Protein Coding gene. Diseases associated with ATP1B4 include thyrotoxic periodic paralysis. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Salivary secretion. GO annotations related to this gene include monovalent inorganic cation transmembrane transporter activity. An important paralog of this gene is ATP1B3.
UniProtKB/Swiss-Prot for ATP1B4 Gene
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit.
Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients across the plasma membrane.