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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP1B3 Gene

protein-coding   GIFtS: 62
GCID: GC03P141594

ATPase, Na+/K+ Transporting, Beta 3 Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATPase, Na+/K+ Transporting, Beta 3 Polypeptide1 2     CD2982
Sodium Pump Subunit Beta-31 2     Na, K-ATPase Beta-3 Polypeptide2
Sodium-Potassium ATPase Subunit Beta 3 (Non-Catalytic)1 2     Sodium/Potassium-Dependent ATPase Beta-3 Subunit2
Sodium/Potassium-Transporting ATPase Subunit Beta-31 2     Sodium/Potassium-Transporting ATPase Beta-3 Chain2
Sodium/Potassium-Dependent ATPase Subunit Beta-32 3     CD298 Antigen3
ATPB-32 3     

External Ids:    HGNC: 8061   Entrez Gene: 4832   Ensembl: ENSG000000698497   OMIM: 6018675   UniProtKB: P547093   

Export aliases for ATP1B3 gene to outside databases

Previous GC identifers: GC03P138528 GC03P142424 GC03P142876 GC03P142916 GC03P143078 GC03P138968


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP1B3 Gene:
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the
subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and
maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are
essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and
for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic
subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of
alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit
of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3
subunit. A pseudogene exists for this gene, and it is located on chromosome 2. (provided by RefSeq, Jul 2008)

GeneCards Summary for ATP1B3 Gene: 
ATP1B3 (ATPase, Na+/K+ transporting, beta 3 polypeptide) is a protein-coding gene. Diseases associated with ATP1B3 include pancreatitis, and hepatitis, and among its related super-pathways are Thyroid hormone synthesis and Salivary secretion. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B1.

UniProtKB/Swiss-Prot: AT1B3_HUMAN, P54709
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled
with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is
not known

summary for ATP1B3 Gene:
Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients
across the plasma membrane.

Gene Wiki entry for ATP1B3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP1B3 gene promoter:
         Sox5   Pbx1a   AML1a   GATA-2   PPAR-gamma1   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP1B3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP1B3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP1B3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

ATP1B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP1B3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P141594:  view genomic region     (about GC identifiers)

Start:
141,594,966 bp from pter      End:
141,645,382 bp from pter
Size:
50,417 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AT1B3_HUMAN, P54709 (See protein sequence)
Recommended Name: Sodium/potassium-transporting ATPase subunit beta-3  
Size: 279 amino acids; 31513 Da
Subunit: Composed of three subunits: alpha (catalytic), beta and gamma
Subcellular location: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass
spectrometry in melanosome fractions from stage I to stage IV

Explore the universe of human proteins at neXtProt for ATP1B3: NX_P54709

Explore proteomics data for ATP1B3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54709

  • ATP1B3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATP1B3 Protein Expression
    REFSEQ proteins: NP_001670.1  
    ENSEMBL proteins: 
     ENSP00000417522   ENSP00000286371   ENSP00000418280   ENSP00000418952   ENSP00000418353  
     ENSP00000419962   ENSP00000417608   ENSP00000440307  
    Reactome Protein details: P54709
    Human Recombinant Protein Products for ATP1B3: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005890sodium:potassium-exchanging ATPase complex IEA--
    GO:0005901caveola IEA--
    GO:0042470melanosome IEA--

    ATP1B3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    PATP: ATPases / P-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: β3 
    Na+/K+-ATPase

    1 InterPro protein domain:
     IPR000402 Na/K_ATPase_sub_beta

    Graphical View of Domain Structure for InterPro Entry P54709

    ProtoNet protein and cluster: P54709

    1 Blocks protein domain: IPB000402 Na+/K+ ATPase

    UniProtKB/Swiss-Prot: AT1B3_HUMAN, P54709
    Domain: The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties (By
    similarity)
    Similarity: Belongs to the X(+)/potassium ATPases subunit beta family


    ATP1B3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT1B3_HUMAN, P54709
    Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled
    with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is
    not known

         Genatlas biochemistry entry for ATP1B3:
    ATPase,Na+K+,beta 3 polypeptide,widely expressed throughout the CNS,dimerizing with ATP alpha 1,2 or 3,with
    structural homology to ATP1B2 and ATP4B

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005391sodium:potassium-exchanging ATPase activity IEA--
    GO:0005515protein binding ----
         
    ATP1B3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ATP1B3:
     Elongated cells  Increased gamma-H2AX phosphory  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATP1B3 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Insulin secretion0.36
    Thyroid hormone synthesis0.36
    2Gastric acid secretion
    Gastric acid secretion0.34
    Salivary secretion0.34
    3Ion channel transport
    Ion channel transport0.49
    Ion transport by P-type ATPases0.32
    4SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Aldosterone Signaling in Epithelial Cells0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATP1B3
        Hepatic ABC Transporters
    Aldosterone Signaling in Epithelial Cells

    1 BioSystems Pathway for ATP1B3
        Calcium Regulation in the Cardiac Cell


    5/6        Reactome Pathways for ATP1B3 (see all 6)
        Hemostasis
    Transmembrane transport of small molecules
    Ion channel transport
    Basigin interactions
    Ion transport by P-type ATPases


    5/13         Kegg Pathways  (Kegg details for ATP1B3) (see all 13):
        Cardiac muscle contraction
    Insulin secretion
    Thyroid hormone synthesis
    Aldosterone-regulated sodium reabsorption
    Endocrine and other factor-regulated calcium reabsorption


    ATP1B3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP1B3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/22 Interacting proteins for ATP1B3 (P547091, 3 ENSP000002863714) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTP4A3O753651, 3, ENSP000003322744EBI-1054481,EBI-1043866 I2D: score=2 STRING: ENSP00000332274
    ATG10Q9H0Y03I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    BECN1Q144573I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8798450
    GO:0006813potassium ion transport ----
    GO:0006814sodium ion transport ----
    GO:0007596blood coagulation TAS--
    GO:0030001metal ion transport ----

    ATP1B3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for ATP1B3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ATP1B3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Lithium carbonateMood stabilizer; inhibits Na+/K+ ATPase pump activity[554-13-2]
    Digoxin Na+, K+-ATPase inhibitor [20830-75-5]

    7 HMDB Compounds for ATP1B3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    PotassiumK+ (see all 16)7440-09-7--
    SodiumSodium (see all 2)7440-23-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about ATP1B3 / AT1B3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATP1B3 gene: 
    NM_001679.2  

    Unigene Cluster for ATP1B3:

    ATPase, Na+/K+ transporting, beta 3 polypeptide
    Hs.477789  [show with all ESTs]
    Unigene Representative Sequence: AK094673
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475483 ENST00000286371 ENST00000465172(uc003eug.1 uc011bne.1)
    ENST00000466678 ENST00000462082 ENST00000495216 ENST00000482635 ENST00000487199
    ENST00000484727 ENST00000486782 ENST00000539728
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    Additional mRNA sequence: 

    AK094673.1 AK131061.1 AK293697.1 AY946018.1 BC001469.2 BC011835.2 U51478.1 

    24/26 DOTS entries (see all 26):

    DT.92015094  DT.449438  DT.92451534  DT.97860922  DT.100038448  DT.95261477  DT.97805336  DT.100826968 
    DT.40303240  DT.100651202  DT.100826961  DT.100826972  DT.40116369  DT.65287606  DT.91866012  DT.95261331 
    DT.100826970  DT.40291501  DT.120897551  DT.95187760  DT.95289452  DT.100826957  DT.120897501  DT.92451535 

    24/544 AceView cDNA sequences (see all 544):

    CN481414 CD723912 CD677431 AI589907 CA419778 CD368198 BU686898 CB155040 
    BM700402 AA315736 CD675455 AI127310 BQ438044 BM786142 AA126850 AA171999 
    BU683530 AI261277 BU632117 CB111184 AI831429 CD107979 AI131139 F07453 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ATP1B3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                                                    
    SP2:                    -                                                               
    SP3:        -     -     -                                                               
    SP4:                    -                             -     -     -     -               
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ATP1B3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP1B3 expression in normal human tissues (normalized intensities)      ATP1B3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGATGGGG
    ATP1B3 Expression
    About this image


    ATP1B3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/37 selected tissues (see all 37) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart muscle ; myocytes   
             heart/atrium   

    See ATP1B3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP1B3

    SOURCE GeneReport for Unigene cluster: Hs.477789
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ATP1B3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp1b31 , 5 ATPase, Na+/K+ transporting, beta 3 polypeptide1, 5 79.5(n)1
    73.74(a)1
      9 (50.31 cM)5
    119331  NM_007502.41  NP_031528.11 
     963326805 
    chicken
    (Gallus gallus)
    Aves ATP1B31 ATPase, Na+/K+ transporting, beta 3 polypeptide 67.27(n)
    61.45(a)
      396549  NM_205535.1  NP_990866.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATP1B36
    Uncharacterized protein
    60(a)
    1 ↔ 1
    3(22053387-22110991)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046716.12   -- 75.65(n)    BC046716.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059426.12   -- 75.25(n)   30468  BC059426.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nrv16
    nrv36
    (see all 3)
    nervana 3
    (see all 3)
    28(a)
    26(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2L(6778555-6786861)
    2L(21380000-21393319)
    worm
    (Caenorhabditis elegans)
    Secernentea nkb-16
    nkb-36
    Sodium/potassium-transporting ATPase subunit beta-...
    Probable sodium/potassium-transporting ATPase subu...
    25(a)
    25(a)
    many ↔ many
    many ↔ many
    I(9431247-9433811)
    X(13765353-13770562)


    ENSEMBL Gene Tree for ATP1B3 (if available)
    TreeFam Gene Tree for ATP1B3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP1B3 gene
    ATP1B12  ATP1B42  ATP1B22  ATP4B2  
    4 SIMAP similar genes for ATP1B3 using alignment to 10 protein entries:     AT1B3_HUMAN (see all proteins):
    ATP1B4    ATP1B2    ATP4B    ATP1B1

    ATP1B3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ATP1B3
    PGOHUM00000247726 PGOHUM00000240054


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1142 SNPs in ATP1B3 are shown (see all 1142)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921407651,2
    --141593709(+) ATCTCG/TGCTCA 1 -- us2k10--------
    rs1413725911,2
    C--141593724(+) AAGCTC/TCGCTT 1 -- us2k10--------
    rs1832458261,2
    C--141593928(+) CCACCA/GCGCCC 1 -- us2k10--------
    rs1891531881,2
    --141594193(+) TTTGTA/GGGAGG 1 -- us2k10--------
    rs1394282841,2
    C--141594390(+) AAATA-/AACAACAA 1 -- us2k10--------
    rs109354421,2
    C,F,A,H--141594417(+) CCCACC/GCCGCA 1 -- us2k18Minor allele frequency- G:0.12NS EA NA 664
    rs1125626481,2
    C--141594482(+) CCCCCC/ACTCCC 1 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs109354431,2
    C,F,A,H--141594547(+) CCCAAG/AGGCCG 1 -- us2k117Minor allele frequency- A:0.09NS EA NA 2218
    rs1469986331,2
    --141594698(+) CACGTA/GTTTAG 1 -- us2k10--------
    rs168462851,2
    F--141594747(+) ATACTC/GCATTC 1 -- us2k12Minor allele frequency- G:0.03MN EA 356

    HapMap Linkage Disequilibrium report for ATP1B3 (141594966 - 141645382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ATP1B3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2656624CNV Deletion23128226
    esv25294CNV Loss19812545
    esv33484CNV Gain17666407

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601867    OMIM disorders: --

    2 diseases for ATP1B3:    About MalaCards
    pancreatitis    hepatitis


    ATP1B3 for disorders           About GeneDecksing


    Export disorders for ATP1B3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP1B3 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with ATP1B3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural organization and chromosomal localization of the human Na,K- ATPase beta 3 subunit gene and pseudogene. (PubMed id 9457675)1, 2, 3 Malik N.... Levenson R. (1998)
    2. Identification of the mammalian Na,K-ATPase 3 subunit. (PubMed id 8798450)1, 2, 3 Malik N.... Levenson R. (1996)
    3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    6. Novel, gel-free proteomics approach identifies RNF5 an d JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (2013)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. The ubiquitin specific protease-4 (USP4) interacts wit h the S9/Rpn6 subunit of the proteasome. (PubMed id 23022198)1 Zhao B....Lindsten K. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Association of connexin43 with E3 ubiquitin ligase TRI M21 reveals a mechanism for gap junction phosphodegron control. (PubMed id 23106098)1 Chen V.C....Naus C.C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 483 HGNC: 806 AceView: ATP1B3 Ensembl:ENSG00000069849 euGenes: HUgn483
    ECgene: ATP1B3 Kegg: 483 H-InvDB: ATP1B3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP1B3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATP1B3 gene:
    Search GeneIP for patents involving ATP1B3

    Licensable Technologies for ATP1B3 gene:
    Weizmann Institute:"Na, K-ATPase Isoforms and Selective Inhibitors Thereof"
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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