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Aliases for ATP1B3 Gene

Aliases for ATP1B3 Gene

  • ATPase Na+/K+ Transporting Subunit Beta 3 2 3 5
  • Sodium-Potassium ATPase Subunit Beta 3 (Non-Catalytic) 2 3
  • Sodium/Potassium-Transporting ATPase Subunit Beta-3 2 3
  • Sodium/Potassium-Dependent ATPase Subunit Beta-3 3 4
  • ATPase, Na+/K+ Transporting, Beta 3 Polypeptide 2 3
  • Sodium Pump Subunit Beta-3 2 3
  • ATPB-3 3 4
  • Sodium/Potassium-Transporting ATPase Beta-3 Chain 3
  • Na, K-ATPase Beta-3 Polypeptide 3
  • CD298 Antigen 4
  • CD298 3

External Ids for ATP1B3 Gene

Previous GeneCards Identifiers for ATP1B3 Gene

  • GC03P138528
  • GC03P142424
  • GC03P142876
  • GC03P142916
  • GC03P143078
  • GC03P141594
  • GC03P138968

Summaries for ATP1B3 Gene

Entrez Gene Summary for ATP1B3 Gene

  • The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP1B3 Gene

ATP1B3 (ATPase Na+/K+ Transporting Subunit Beta 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization. GO annotations related to this gene include ATPase binding and sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B2.

UniProtKB/Swiss-Prot for ATP1B3 Gene

  • This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Tocris Summary for ATP1B3 Gene

  • The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.

Gene Wiki entry for ATP1B3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP1B3 Gene

Genomics for ATP1B3 Gene

Regulatory Elements for ATP1B3 Gene

Enhancers for ATP1B3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G141848 1 Ensembl 18.1 -26.7 -26675 0.9 HDGF ARNT TCF12 ZNF766 GATA2 KLF13 NCOA1 ZNF592 MEF2D MBD2 ATP1B3 RNF7 GRK7 GK5 LOC105374134 PIR31846
GH03G141736 1.5 FANTOM5 ENCODE 11.6 -136.2 -136182 6.0 HDGF HNRNPUL1 FOXA2 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 RNF7 ATP1B3 ATP1B3-AS1 GRK7 RNU6-509P RASA2
GH03G141913 0.8 ENCODE 20.6 +37.3 37270 0.2 HDGF CTCF CBX3 RAD21 CHAMP1 TEAD3 ZNF316 CBX5 ZSCAN5C ADNP ATP1B3 RNF7 GRK7 RNU6-425P ATP1B3-AS1 GC03M141903 RNU6-509P
GH03G141795 1.3 FANTOM5 Ensembl ENCODE 12.1 -78.9 -78887 4.0 TFAP4 ZNF146 SUZ12 TEAD4 MAX RBBP5 POLR2A HLF NRF1 CBFB ATP1B3 RNF7 GRK7 RASA2 TFDP2 GK5 PIR31846 LOC105374134
GH03G141949 0.8 ENCODE 18.9 +74.3 74338 2.2 ELF3 CBX3 SAP130 CEBPG EBF1 RARA CBX5 POLR2A NCOR1 NR2F6 ATP1B3 ATP1B3-AS1 RNU6-509P GC03M141945 PIR46950
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP1B3 on UCSC Golden Path with GeneCards custom track

Promoters for ATP1B3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159392 676 4001 ARID4B SIN3A YY1 CBX5 ZNF143 FOS SP5 ZHX2 MXD4 REST

Genomic Location for ATP1B3 Gene

Chromosome:
3
Start:
141,876,124 bp from pter
End:
141,926,540 bp from pter
Size:
50,417 bases
Orientation:
Plus strand

Genomic View for ATP1B3 Gene

Genes around ATP1B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP1B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP1B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1B3 Gene

Proteins for ATP1B3 Gene

  • Protein details for ATP1B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54709-AT1B3_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-3
    Protein Accession:
    P54709
    Secondary Accessions:
    • B7Z1N7

    Protein attributes for ATP1B3 Gene

    Size:
    279 amino acids
    Molecular mass:
    31513 Da
    Quaternary structure:
    • Composed of three subunits: alpha (catalytic), beta and gamma.

    Alternative splice isoforms for ATP1B3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP1B3 Gene

Post-translational modifications for ATP1B3 Gene

  • Ubiquitination at posLast=77, Lys115, and posLast=194194
  • Glycosylation at posLast=124124 and posLast=240240
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP1B3 Gene

Antibody Products

  • Abcam antibodies for ATP1B3
  • Cloud-Clone Corp. Antibodies for ATP1B3

No data available for DME Specific Peptides for ATP1B3 Gene

Domains & Families for ATP1B3 Gene

Gene Families for ATP1B3 Gene

Protein Domains for ATP1B3 Gene

Graphical View of Domain Structure for InterPro Entry

P54709

UniProtKB/Swiss-Prot:

AT1B3_HUMAN :
  • The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
Domain:
  • The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.
Family:
  • Belongs to the X(+)/potassium ATPases subunit beta family.
genes like me logo Genes that share domains with ATP1B3: view

Function for ATP1B3 Gene

Molecular function for ATP1B3 Gene

GENATLAS Biochemistry:
ATPase,Na+K+,beta 3 polypeptide,widely expressed throughout the CNS,dimerizing with ATP alpha 1,2 or 3,with structural homology to ATP1B2 and ATP4B
UniProtKB/Swiss-Prot Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Gene Ontology (GO) - Molecular Function for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 10636900
GO:0005391 contributes_to sodium:potassium-exchanging ATPase activity TAS,IDA 10636900
GO:0051117 ATPase binding IPI 10636900
genes like me logo Genes that share ontologies with ATP1B3: view
genes like me logo Genes that share phenotypes with ATP1B3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP1B3

miRNA for ATP1B3 Gene

miRTarBase miRNAs that target ATP1B3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP1B3 Gene

Localization for ATP1B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1B3 Gene

Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP1B3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IEA,IDA 10636900
GO:0005901 caveola IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP1B3: view

Pathways & Interactions for ATP1B3 Gene

genes like me logo Genes that share pathways with ATP1B3: view

Gene Ontology (GO) - Biological Process for ATP1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8798450
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006883 cellular sodium ion homeostasis IDA 10636900
genes like me logo Genes that share ontologies with ATP1B3: view

No data available for SIGNOR curated interactions for ATP1B3 Gene

Drugs & Compounds for ATP1B3 Gene

(8) Drugs for ATP1B3 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rubidium chloride Rb-82 Approved Pharma Carrier, substrate 0
Potassium Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Lansoprazole Approved, Investigational Pharma H+,K+-ATPase inhibitor 218

(4) Additional Compounds for ATP1B3 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
PF 3716556
928774-43-0

(4) Tocris Compounds for ATP1B3 Gene

Compound Action Cas Number
Lansoprazole H+,K+-ATPase inhibitor 103577-45-3
Omeprazole H+,K+-ATPase inhibitor 73590-58-6
PF 3716556 Selective H+,K+-ATPase inhibitor 928774-43-0
SCH 28080 H+,K+-ATPase inhibitor 76081-98-6
genes like me logo Genes that share compounds with ATP1B3: view

Transcripts for ATP1B3 Gene

Unigene Clusters for ATP1B3 Gene

ATPase, Na+/K+ transporting, beta 3 polypeptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1B3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -
SP3: - - -
SP4: - - - - -
SP5:

Relevant External Links for ATP1B3 Gene

GeneLoc Exon Structure for
ATP1B3
ECgene alternative splicing isoforms for
ATP1B3

Expression for ATP1B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP1B3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP1B3 Gene



Protein tissue co-expression partners for ATP1B3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP1B3 Gene:

ATP1B3

SOURCE GeneReport for Unigene cluster for ATP1B3 Gene:

Hs.477789

Evidence on tissue expression from TISSUES for ATP1B3 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Skin(3.1)
  • Stomach(2.7)
  • Intestine(2.6)
  • Adrenal gland(2.5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ATP1B3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP1B3 Gene

Orthologs for ATP1B3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP1B3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP1B3 34 35
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia ATP1B3 34 35
  • 86.57 (n)
cow
(Bos Taurus)
Mammalia ATP1B3 34 35
  • 83.03 (n)
rat
(Rattus norvegicus)
Mammalia Atp1b3 34
  • 80.41 (n)
mouse
(Mus musculus)
Mammalia Atp1b3 34 16 35
  • 79.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATP1B3 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP1B3 34 35
  • 67.27 (n)
lizard
(Anolis carolinensis)
Reptilia ATP1B3 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp1b3 34
  • 61.42 (n)
MGC76183 34
zebrafish
(Danio rerio)
Actinopterygii atp1b3a 34 35
  • 56.73 (n)
atp1b3b 35
  • 52 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta nrv1 35
  • 29 (a)
ManyToMany
nrv3 35
  • 26 (a)
ManyToMany
nrv2 35
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nkb-1 35
  • 26 (a)
ManyToMany
nkb-3 35
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 35
  • 27 (a)
OneToMany
Species where no ortholog for ATP1B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP1B3 Gene

ENSEMBL:
Gene Tree for ATP1B3 (if available)
TreeFam:
Gene Tree for ATP1B3 (if available)

Paralogs for ATP1B3 Gene

Paralogs for ATP1B3 Gene

Pseudogenes.org Pseudogenes for ATP1B3 Gene

genes like me logo Genes that share paralogs with ATP1B3: view

Variants for ATP1B3 Gene

Sequence variations from dbSNP and Humsavar for ATP1B3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000099204 -- 141,884,262(+) CTGTG(C/G)GTAAG intron-variant
rs1000129013 -- 141,910,566(+) CATCT(A/G)TAGAT intron-variant
rs1000130822 -- 141,902,369(+) AGCAC(A/C)ATCTG intron-variant
rs1000193111 -- 141,905,501(+) GAGCT(A/G)TATCA intron-variant
rs1000224389 -- 141,905,894(+) CGATT(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP1B3 Gene

Variant ID Type Subtype PubMed ID
dgv8623n54 CNV gain 21841781
dgv8624n54 CNV gain 21841781
esv25294 CNV loss 19812545
esv2656624 CNV deletion 23128226
esv33484 CNV gain 17666407
nsv1013352 CNV gain 25217958
nsv1126657 CNV deletion 24896259
nsv591902 CNV gain 21841781
nsv591905 CNV gain 21841781
nsv591906 CNV loss 21841781
nsv591907 CNV gain+loss 21841781
nsv591910 CNV gain 21841781
nsv963364 CNV duplication 23825009

Variation tolerance for ATP1B3 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP1B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP1B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP1B3 Gene

Disorders for ATP1B3 Gene

Relevant External Links for ATP1B3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP1B3

No disorders were found for ATP1B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP1B3 Gene

Publications for ATP1B3 Gene

  1. Structural organization and chromosomal localization of the human Na,K- ATPase beta 3 subunit gene and pseudogene. (PMID: 9457675) Malik N. … Levenson R. (Mamm. Genome 1998) 2 3 4 64
  2. Identification of the mammalian Na,K-ATPase 3 subunit. (PMID: 8798450) Malik N. … Levenson R. (J. Biol. Chem. 1996) 2 3 4 64
  3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ATP1B3 Gene

Sources for ATP1B3 Gene

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