Aliases for ATP1B2 Gene
External Ids for ATP1B2 Gene
Previous GeneCards Identifiers for ATP1B2 Gene
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for ATP1B2 Gene
ATP1B2 (ATPase, Na+/K+ Transporting, Beta 2 Polypeptide) is a Protein Coding gene. Diseases associated with ATP1B2 include x-linked juvenile retinoschisis and juvenile retinoschisis. Among its related pathways are Hemostasis and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B3.
UniProtKB/Swiss-Prot for ATP1B2 Gene
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients across the plasma membrane.