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Aliases for ATP1B2 Gene

Aliases for ATP1B2 Gene

  • ATPase Na+/K+ Transporting Subunit Beta 2 2 3 5
  • Sodium-Potassium ATPase Subunit Beta 2 (Non-Catalytic) 2 3
  • Sodium/Potassium-Transporting ATPase Subunit Beta-2 2 3
  • Sodium/Potassium-Dependent ATPase Subunit Beta-2 3 4
  • ATPase, Na+/K+ Transporting, Beta 2 Polypeptide 2 3
  • Sodium Pump Subunit Beta-2 2 3
  • Adhesion Molecule In Glia 3 4
  • AMOG 3 4
  • Sodium/Potassium-Transporting ATPase Beta-2 Chain 3
  • Sodium/Potassium-Dependent ATPase Beta-2 Subunit 3
  • Na, K-ATPase Beta-2 Polypeptide 3
  • Adhesion Molecule On Glia 3

External Ids for ATP1B2 Gene

Previous GeneCards Identifiers for ATP1B2 Gene

  • GC17M008057
  • GC17P008294
  • GC17P007497
  • GC17P007755
  • GC17P007754
  • GC17P007494
  • GC17P007554
  • GC17P007448
  • GC17P007557
  • GC17P007567
  • GC17P007574
  • GC17P007650

Summaries for ATP1B2 Gene

Entrez Gene Summary for ATP1B2 Gene

  • The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for ATP1B2 Gene

ATP1B2 (ATPase Na+/K+ Transporting Subunit Beta 2) is a Protein Coding gene. Diseases associated with ATP1B2 include Thyrotoxic Periodic Paralysis and Hemiplegic Migraine. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization. GO annotations related to this gene include ATPase binding and sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B3.

UniProtKB/Swiss-Prot for ATP1B2 Gene

  • This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.

  • Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

Tocris Summary for ATP1B2 Gene

  • The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP1B2 Gene

Genomics for ATP1B2 Gene

Regulatory Elements for ATP1B2 Gene

Enhancers for ATP1B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G007233 1.5 ENCODE dbSUPER 23.4 -407.9 -407947 11.3 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 DVL2 NLGN2 ELP5 SNORD10 NEURL4 ZBTB4 SNORA48 LOC100996842 SENP3 YBX2
GH17G008185 1.5 ENCODE dbSUPER 23.4 +541.8 541757 5.8 MLX CREB3L1 AGO1 ZFP64 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 DVL2 PFAS CTC1 SNORD10 ENSG00000265749 SNORA48 CNTROB NEURL4 NLGN2 LOC100996842
GH17G007171 1.2 Ensembl ENCODE 23.4 -472.9 -472947 4.2 FOXA2 ZNF133 YBX1 GLI4 ZNF207 KLF7 ZNF548 PAF1 ZNF202 ZNF662 DVL2 NLGN2 NEURL4 SNORD10 ATP1B2 SNORA48 MIR324 ZBTB4 PER1 LOC100996842
GH17G007833 1.9 FANTOM5 ENCODE dbSUPER 14.3 +193.1 193103 12.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 DVL2 PFAS CTC1 NLGN2 SNORD10 PER1 SNORA48 KDM6B RPL26 VAMP2
GH17G007676 1 ENCODE 26.3 +30.7 30718 1.7 HNRNPUL1 HDGF PKNOX1 AGO1 YY1 TCF12 ZNF207 ZNF263 ZNF488 REST NLGN2 PFAS ATP1B2 EFNB3 DVL2 SNORD10 RPL26 VAMP2 SNORA48 ZBTB4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP1B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP1B2 Gene

Chromosome:
17
Start:
7,646,627 bp from pter
End:
7,657,771 bp from pter
Size:
11,145 bases
Orientation:
Plus strand

Genomic View for ATP1B2 Gene

Genes around ATP1B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP1B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP1B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1B2 Gene

Proteins for ATP1B2 Gene

  • Protein details for ATP1B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14415-AT1B2_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-2
    Protein Accession:
    P14415
    Secondary Accessions:
    • A0AV17
    • A8K278
    • D3DTQ2
    • O60444

    Protein attributes for ATP1B2 Gene

    Size:
    290 amino acids
    Molecular mass:
    33367 Da
    Quaternary structure:
    • Composed of three subunits: alpha (catalytic), beta and gamma.

neXtProt entry for ATP1B2 Gene

Post-translational modifications for ATP1B2 Gene

  • Glycosylation at Asn96, Asn118, posLast=153153, posLast=159159, posLast=193193, posLast=197197, posLast=238238, and posLast=250250
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP1B2 Gene

No data available for DME Specific Peptides for ATP1B2 Gene

Domains & Families for ATP1B2 Gene

Gene Families for ATP1B2 Gene

Protein Domains for ATP1B2 Gene

Suggested Antigen Peptide Sequences for ATP1B2 Gene

Graphical View of Domain Structure for InterPro Entry

P14415

UniProtKB/Swiss-Prot:

AT1B2_HUMAN :
  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
  • Belongs to the X(+)/potassium ATPases subunit beta family.
Domain:
  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
Family:
  • Belongs to the X(+)/potassium ATPases subunit beta family.
genes like me logo Genes that share domains with ATP1B2: view

Function for ATP1B2 Gene

Molecular function for ATP1B2 Gene

GENATLAS Biochemistry:
ATPase,Na+K+ beta 2 polypeptide,putative adhesion molecule on glia,specific
UniProtKB/Swiss-Prot Function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
UniProtKB/Swiss-Prot Function:
Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

Gene Ontology (GO) - Molecular Function for ATP1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 10636900
GO:0005391 contributes_to sodium:potassium-exchanging ATPase activity TAS,IDA 10636900
GO:0005515 protein binding IPI 11027149
GO:0051117 ATPase binding IPI 10636900
genes like me logo Genes that share ontologies with ATP1B2: view
genes like me logo Genes that share phenotypes with ATP1B2: view

Animal Models for ATP1B2 Gene

MGI Knock Outs for ATP1B2:

Animal Model Products

CRISPR Products

miRNA for ATP1B2 Gene

miRTarBase miRNAs that target ATP1B2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP1B2 Gene

Localization for ATP1B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1B2 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP1B2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ATP1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IDA,IEA 10636900
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP1B2: view

Pathways & Interactions for ATP1B2 Gene

genes like me logo Genes that share pathways with ATP1B2: view

Gene Ontology (GO) - Biological Process for ATP1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 2538450
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006883 cellular sodium ion homeostasis IDA 10636900
genes like me logo Genes that share ontologies with ATP1B2: view

No data available for SIGNOR curated interactions for ATP1B2 Gene

Drugs & Compounds for ATP1B2 Gene

(8) Drugs for ATP1B2 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rubidium chloride Rb-82 Approved Pharma Carrier, substrate 0
Potassium Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Lansoprazole Approved, Investigational Pharma H+,K+-ATPase inhibitor 218

(4) Additional Compounds for ATP1B2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
PF 3716556
928774-43-0

(4) Tocris Compounds for ATP1B2 Gene

Compound Action Cas Number
Lansoprazole H+,K+-ATPase inhibitor 103577-45-3
Omeprazole H+,K+-ATPase inhibitor 73590-58-6
PF 3716556 Selective H+,K+-ATPase inhibitor 928774-43-0
SCH 28080 H+,K+-ATPase inhibitor 76081-98-6
genes like me logo Genes that share compounds with ATP1B2: view

Transcripts for ATP1B2 Gene

mRNA/cDNA for ATP1B2 Gene

Unigene Clusters for ATP1B2 Gene

ATPase, Na+/K+ transporting, beta 2 polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1B2 Gene

No ASD Table

Relevant External Links for ATP1B2 Gene

GeneLoc Exon Structure for
ATP1B2
ECgene alternative splicing isoforms for
ATP1B2

Expression for ATP1B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP1B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP1B2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.2), Brain - Cerebellum (x5.1), Brain - Nucleus accumbens (basal ganglia) (x4.9), Brain - Putamen (basal ganglia) (x4.8), Brain - Amygdala (x4.5), and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for ATP1B2 Gene

This gene is overexpressed in Retina (31.6), Frontal cortex (14.4), and Spinal cord (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP1B2 Gene



Protein tissue co-expression partners for ATP1B2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATP1B2 Gene:

ATP1B2

SOURCE GeneReport for Unigene cluster for ATP1B2 Gene:

Hs.643540

Evidence on tissue expression from TISSUES for ATP1B2 Gene

  • Nervous system(5)
  • Eye(4.5)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with ATP1B2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP1B2 Gene

Orthologs for ATP1B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP1B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP1B2 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia ATP1B2 34 35
  • 94.14 (n)
cow
(Bos Taurus)
Mammalia ATP1B2 34 35
  • 93.68 (n)
rat
(Rattus norvegicus)
Mammalia Atp1b2 34
  • 91.03 (n)
mouse
(Mus musculus)
Mammalia Atp1b2 34 16 35
  • 90.92 (n)
oppossum
(Monodelphis domestica)
Mammalia ATP1B2 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP1B2 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp1b2 34
  • 64 (n)
MGC75733 34
African clawed frog
(Xenopus laevis)
Amphibia atp1b2-prov 34
zebrafish
(Danio rerio)
Actinopterygii atp1b2b 35 34
  • 64.08 (n)
OneToMany
atp1b2a 35
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nrv1 34 35
  • 47.99 (n)
nrv3 35
  • 26 (a)
ManyToMany
nrv2 35
  • 23 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007790 34
  • 45.4 (n)
worm
(Caenorhabditis elegans)
Secernentea nkb-3 35
  • 25 (a)
ManyToMany
nkb-1 35
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 35
  • 29 (a)
OneToMany
Species where no ortholog for ATP1B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP1B2 Gene

ENSEMBL:
Gene Tree for ATP1B2 (if available)
TreeFam:
Gene Tree for ATP1B2 (if available)

Paralogs for ATP1B2 Gene

Paralogs for ATP1B2 Gene

(4) SIMAP similar genes for ATP1B2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATP1B2: view

Variants for ATP1B2 Gene

Sequence variations from dbSNP and Humsavar for ATP1B2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000141906 -- 7,656,112(+) AGATC(A/G)GTCAG utr-variant-3-prime
rs1000745886 -- 7,654,971(+) CTAAC(A/G)CTTCC intron-variant
rs1000851438 -- 7,649,934(+) TGATC(C/T)GCCCG intron-variant, upstream-variant-2KB
rs1000861094 -- 7,649,405(+) TTTTT(C/T)GAGAC intron-variant, upstream-variant-2KB
rs1000873891 -- 7,645,101(+) GGATG(C/T)GGTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ATP1B2 Gene

Variant ID Type Subtype PubMed ID
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for ATP1B2 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP1B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP1B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP1B2 Gene

Disorders for ATP1B2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ATP1B2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
thyrotoxic periodic paralysis
  • thyrotoxic hypokalemic periodic paralysis
hemiplegic migraine
  • migraine hemiplegic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ATP1B2

Genetic Association Database (GAD)
ATP1B2
Human Genome Epidemiology (HuGE) Navigator
ATP1B2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP1B2
genes like me logo Genes that share disorders with ATP1B2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP1B2 Gene

Publications for ATP1B2 Gene

  1. Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes. (PMID: 16430714) Kung A.W. … Chan V. (Clin. Endocrinol. (Oxf) 2006) 3 22 46 64
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  3. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64
  4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 64
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 46 64

Products for ATP1B2 Gene

Sources for ATP1B2 Gene

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