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Aliases for ATP1B2 Gene

Aliases for ATP1B2 Gene

  • ATPase, Na+/K+ Transporting, Beta 2 Polypeptide 2 3
  • AMOG 3 4 6
  • Sodium-Potassium ATPase Subunit Beta 2 (Non-Catalytic) 2 3
  • Sodium/Potassium-Transporting ATPase Subunit Beta-2 2 3
  • Sodium/Potassium-Dependent ATPase Subunit Beta-2 3 4
  • Sodium Pump Subunit Beta-2 2 3
  • Adhesion Molecule In Glia 3 4
  • Sodium/Potassium-Transporting ATPase Beta-2 Chain 3
  • Sodium/Potassium-Dependent ATPase Beta-2 Subunit 3
  • Na, K-ATPase Beta-2 Polypeptide 3
  • Adhesion Molecule On Glia 3

External Ids for ATP1B2 Gene

Summaries for ATP1B2 Gene

Entrez Gene Summary for ATP1B2 Gene

  • The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for ATP1B2 Gene

ATP1B2 (ATPase, Na+/K+ Transporting, Beta 2 Polypeptide) is a Protein Coding gene. Diseases associated with ATP1B2 include x-linked juvenile retinoschisis and juvenile retinoschisis. Among its related pathways are Hemostasis and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B3.

UniProtKB/Swiss-Prot for ATP1B2 Gene

  • This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known

  • Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

Tocris Summary for ATP1B2 Gene

  • Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients across the plasma membrane.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP1B2 Gene

Genomics for ATP1B2 Gene

Genomic Location for ATP1B2 Gene

Start:
7,646,627 bp from pter
End:
7,657,771 bp from pter
Size:
11,145 bases
Orientation:
Plus strand

Genomic View for ATP1B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP1B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1B2 Gene

Regulatory Elements for ATP1B2 Gene

Proteins for ATP1B2 Gene

  • Protein details for ATP1B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14415-AT1B2_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-2
    Protein Accession:
    P14415
    Secondary Accessions:
    • A0AV17
    • A8K278
    • D3DTQ2
    • O60444

    Protein attributes for ATP1B2 Gene

    Size:
    290 amino acids
    Molecular mass:
    33367 Da
    Quaternary structure:
    • Composed of three subunits: alpha (catalytic), beta and gamma

neXtProt entry for ATP1B2 Gene

Proteomics data for ATP1B2 Gene at MOPED

Post-translational modifications for ATP1B2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn96, Asn118, Asn153, Asn159, Asn193, Asn197, and Asn238

Other Protein References for ATP1B2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP1B2 Gene

Domains for ATP1B2 Gene

Gene Families for ATP1B2 Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

Protein Domains for ATP1B2 Gene

UniProtKB/Swiss-Prot:

AT1B2_HUMAN
Domain:
  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.:
    • P14415
Family:
  • Belongs to the X(+)/potassium ATPases subunit beta family.:
    • P14415
genes like me logo Genes that share domains with ATP1B2: view

Function for ATP1B2 Gene

Molecular function for ATP1B2 Gene

GENATLAS Biochemistry: ATPase,Na+K+ beta 2 polypeptide,putative adhesion molecule on glia,specific
UniProtKB/Swiss-Prot Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known
UniProtKB/Swiss-Prot Function: Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

Gene Ontology (GO) - Molecular Function for ATP1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 10636900
GO:0005391 contributes_to sodium:potassium-exchanging ATPase activity IDA 10636900
GO:0005515 protein binding IPI 11027149
GO:0051117 ATPase binding IPI 10636900
genes like me logo Genes that share ontologies with ATP1B2: view
genes like me logo Genes that share phenotypes with ATP1B2: view

Animal Models for ATP1B2 Gene

MGI Knock Outs for ATP1B2:

miRNA for ATP1B2 Gene

miRTarBase miRNAs that target ATP1B2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ATP1B2 Gene

Localization for ATP1B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1B2 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP1B2 Gene COMPARTMENTS Subcellular localization image for ATP1B2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IDA 10636900
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with ATP1B2: view

Pathways for ATP1B2 Gene

genes like me logo Genes that share pathways with ATP1B2: view

Gene Ontology (GO) - Biological Process for ATP1B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 2538450
GO:0006813 potassium ion transport --
GO:0006814 sodium ion transport --
GO:0006883 cellular sodium ion homeostasis IDA 10636900
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with ATP1B2: view

Compounds for ATP1B2 Gene

(2) Tocris Compounds for ATP1B2 Gene

Compound Action Cas Number
Digoxin Na+, K+-ATPase inhibitor [20830-75-5]
Lithium carbonate Mood stabilizer; inhibits Na+/K+ ATPase pump activity [554-13-2]

(7) HMDB Compounds for ATP1B2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
Phosphate
  • NFB Orthophosphate
14265-44-2
Potassium
  • K+
7440-09-7
genes like me logo Genes that share compounds with ATP1B2: view

Transcripts for ATP1B2 Gene

mRNA/cDNA for ATP1B2 Gene

Unigene Clusters for ATP1B2 Gene

ATPase, Na+/K+ transporting, beta 2 polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1B2 Gene

No ASD Table

Relevant External Links for ATP1B2 Gene

GeneLoc Exon Structure for
ATP1B2
ECgene alternative splicing isoforms for
ATP1B2

Expression for ATP1B2 Gene

mRNA expression in normal human tissues for ATP1B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP1B2 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (5.2), Brain - Cerebellum (5.1), Brain - Nucleus accumbens (basal ganglia) (4.9), Brain - Putamen (basal ganglia) (4.8), Brain - Amygdala (4.5), and Brain - Cerebellar Hemisphere (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP1B2 Gene

SOURCE GeneReport for Unigene cluster for ATP1B2 Gene Hs.643540

genes like me logo Genes that share expressions with ATP1B2: view

Orthologs for ATP1B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP1B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP1B2 36
  • 99.66 (n)
  • 100 (a)
ATP1B2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP1B2 36
  • 93.68 (n)
  • 97.93 (a)
ATP1B2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP1B2 36
  • 94.14 (n)
  • 98.62 (a)
ATP1B2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp1b2 36
  • 90.92 (n)
  • 97.24 (a)
Atp1b2 16
Atp1b2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP1B2 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp1b2 36
  • 91.03 (n)
  • 97.59 (a)
lizard
(Anolis carolinensis)
Reptilia ATP1B2 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia atp1b2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia atp1b2 36
  • 64 (n)
  • 55.9 (a)
MGC75733 36
zebrafish
(Danio rerio)
Actinopterygii atp1b2a 37
  • 57 (a)
OneToMany
atp1b2b 36
  • 64.08 (n)
  • 59.41 (a)
atp1b2b 37
  • 55 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007790 36
  • 45.4 (n)
  • 36.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta nrv1 36
  • 47.99 (n)
  • 35.02 (a)
nrv1 37
  • 28 (a)
ManyToMany
nrv2 37
  • 23 (a)
ManyToMany
nrv3 37
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nkb-1 37
  • 24 (a)
ManyToMany
nkb-3 37
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 37
  • 29 (a)
OneToMany
Species with no ortholog for ATP1B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP1B2 Gene

ENSEMBL:
Gene Tree for ATP1B2 (if available)
TreeFam:
Gene Tree for ATP1B2 (if available)

Paralogs for ATP1B2 Gene

Paralogs for ATP1B2 Gene

Selected SIMAP similar genes for ATP1B2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATP1B2: view

Variants for ATP1B2 Gene

Sequence variations from dbSNP and Humsavar for ATP1B2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1050528 -- 7,651,218(+) TTTGG(C/G/T)GGGGG utr-variant-5-prime
rs1050531 -- 7,655,764(+) TGAAG(C/T)TCCTG missense, reference
rs1050532 -- 7,656,588(+) AAATG(A/C)GGGAC utr-variant-3-prime
rs1050533 -- 7,656,976(+) GCGCC(C/T)GGCCT utr-variant-3-prime
rs1050540 -- 7,657,424(+) GCCCA(C/T)AGAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATP1B2 Gene

Variant ID Type Subtype PubMed ID
nsv457659 CNV Loss 19166990
nsv907652 CNV Loss 21882294

Relevant External Links for ATP1B2 Gene

HapMap Linkage Disequilibrium report
ATP1B2

Disorders for ATP1B2 Gene

Relevant External Links for ATP1B2

Genetic Association Database (GAD)
ATP1B2
Human Genome Epidemiology (HuGE) Navigator
ATP1B2
genes like me logo Genes that share disorders with ATP1B2: view

No data available for UniProtKB/Swiss-Prot for ATP1B2 Gene

Publications for ATP1B2 Gene

  1. Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes. (PMID: 16430714) Kung A.W. … Chan V. (Clin. Endocrinol. (Oxf) 2006) 3 23 49
  2. Assignment of Amog (adhesion molecule on glia) gene to mouse chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17. (PMID: 1699290) Hsieh C.L. … Francke U. (Somat. Cell Mol. Genet. 1990) 2 3
  3. Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression. (PMID: 2538450) Martin-Vasallo P. … Levenson R. (J. Biol. Chem. 1989) 3 4
  4. Nucleotide sequence of a cDNA for the beta 2 subunit isoform of Na+,K(+)-ATPase from human retina. (PMID: 8305453) Hernando N. … Coca-Prados M. (Biochim. Biophys. Acta 1994) 3 4
  5. Structure and expression of the human Na,K-ATPase beta 2-subunit gene. (PMID: 9524271) Avila J. … Martin-Vasallo P. (Gene 1998) 3 4

Products for ATP1B2 Gene

Sources for ATP1B2 Gene

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