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ATP1B2 Gene

protein-coding   GIFtS: 63

GC17P007494
ATPase, Na+/K+ transporting, beta 2 polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AMOG 1, 2, 5
Descriptions
ATPase, Na+/K+ transporting, beta 2 polypeptide 2
Na+/K+ -ATPase beta 2 subunit 2
Na, K-ATPase beta-2 polypeptide 2
Sodium/potassium-dependent ATPase subunit beta-2 3
adhesion molecule on glia 2
sodium/potassium-dependent ATPase beta-2 subunit 2
sodium/potassium-transporting ATPase beta-2 chain 2
External Ids
HGNC: 8051
Entrez Gene: 4822
UniProtKB: P144153
Ensembl: ENSG000001292447
Search outside databases for aliases for ATP1B2 gene

Previous GC identifers: GC17M008057 GC17P008294 GC17P007497 GC17P007755 GC17P007754

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ATP1B2:
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain
proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein
responsible for establishing and maintaining the electrochemical gradients of Na and K ions across
the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled
transport of a variety of organic and inorganic molecules, and for electrical excitability of
nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a
smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta
heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein
subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit.
[provided by RefSeq]

UniProtKB/Swiss-Prot: AT1B2_HUMAN, P14415
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis
of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact
function of the beta-2 subunit is not known

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ATP1B2 gene  

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC chromosome: 17

ATP1B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007494:     (about GC identifiers)

Start:
7,494,979 bp from pter
End:
7,501,814 bp from pter
Size:
6,836 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010718.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AT1B2_HUMAN, P14415 (See protein sequence)
Recommended Name: Sodium/potassium-transporting ATPase subunit beta-2  
Size: 290 amino acids; 33367 Da
Subunit: Composed of three subunits: alpha (catalytic), beta and gamma
Subcellular location: Membrane; Single-pass type II membrane protein
Secondary accessions: A0AV17 A8K278 O60444

REFSEQ proteins: NP_001669.3  

ENSEMBL proteins: 
ENSP00000250111 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ATPase Na+/ K+ beta 2)
Human Recombinant Proteins from Abnova (ATP1B2)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for ATP1B2: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of ATP1B2
Sigma-Aldrich Antibodies for ATP1B2
Browse R&D Systems for Antibodies
Antibodies from Abcam (ATPase Na+/ K+ beta 2), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (ATP1B2)
Novus Biologicals Antibody for ATP1B2

Assays for ATP1B2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR000402 ATPase_P-typ_cation-exchng_bsu


   GeneDecks  ATP1B2 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P14415

ProtoNet protein and cluster: P14415

1 Blocks protein family: IPB000402 Na+/K+ ATPase

UniProtKB/Swiss-Prot: AT1B2_HUMAN, P14415
Similarity: Belongs to the X(+)/potassium ATPases subunit beta family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ATP1B2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ATP1B2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001678

              Applied Biosystems Silencer® siRNAs for ATP1B2

              Sigma-Aldrich siRNA and siRNA Panels for ATP1B2  
                     Sigma-Aldrich shRNA for ATP1B2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for ATP1B2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001678
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001678
                                 untagged cDNA clone in CMV expression vector: NM_001678 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001678

UniProtKB/Swiss-Prot: AT1B2_HUMAN, P14415
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis
of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact
function of the beta-2 subunit is not known

Genatlas biochemistry entry for ATP1B2:
ATPase,Na+K+ beta 2 polypeptide,putative adhesion molecule on glia,specific

4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Atp1b2):

behavior/neurologicallethality-postnatalnervous systemvision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005391 sodium:potassium-exchanging ATPase activity TAS2538450
GO:0005515 protein binding IPI11027149
GO:0030955 potassium ion binding IEA--
GO:0031402 sodium ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Millipore Pathway for ATP1B2
 Sodium-coupled transporters and pumps

   GeneDecks  ATP1B2 for the pathways selected above  
About GeneDecksing

1 Kegg Pathway  (Kegg details for ATP1B2):
 hsa04260 Cardiac muscle contraction

   GeneDecks  ATP1B2 for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  ATP1B2 


2 Interacting proteins for ATP1B2 (ENSP000002501113) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
ASGR1ENSP000003703073STRING (score=.715)
ASGR2ENSP000003703293STRING (score=.715)
About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006754 ATP biosynthetic process IEA--
GO:0006811 ion transport IEA--
GO:0006813 potassium ion transport IEA--
GO:0006814 sodium ion transport IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ATP1B2
Browse Small Molecules at Sigma-Aldrich

Compounds for ATP1B2 available from Tocris Bioscience
CompoundAction CAS number
OuabainNa+,K+-ATPase inhibitor[630-60-4]
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (ATP1B2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (ATP1B2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001678

              Sigma-Aldrich siRNA and siRNA Panels for ATP1B2  
                     Sigma-Aldrich shRNA for ATP1B2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001678  

REFSEQ mRNAs for ATP1B2 gene: 

NM_001678.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001678  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001678
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001678
                                 untagged cDNA clone in CMV expression vector: NM_001678 

Additional cDNA sequence: 

AK290143.1 AY946017.1 BC035801.1 BC126175.1 D87330.1 M81181.1 U45945.1 

4 DOTS entries:

DT.92447964  DT.100811679  DT.115586  DT.92447966 

24/160 AceView cDNA sequences (see all 160 ):

BE550304 AW131864 AI656367 AL120033 BM674199 BC035801 BM715871 H08829 
AA457385 BM689476 BM661475 NM_001678 AI589796 AI085636 AA457434 F01423 
BM663637 U45945 BM681927 AA350573 BM668645 BM671338 CD612459 F12107 

highest scoring ESTs for ATP1B2:

AA063041 AA063077 AA330735 AA350573 AA457385 AA457434 AA757646 AA977418 AI085636 AI088697 

Unigene Cluster for ATP1B2:

ATPase, Na+/K+ transporting, beta 2 polypeptide
Hs.712542  [show with all ESTs]
Unigene Representative Sequence: NM_001678


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000250111  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ATP1B2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for ATP1B2

1 / 2 / 3

4 probe-sets matching ATP1B2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
37270_at2, 3 U95-A 1 1.00 1.00 0.97 1.38 AF007876 0.20 1.00 0.72 1
34118_at2, 3 U95-A 2 0.56 0.82 0.99 0.71 W28508 0.60 1.00 0.82 1

204311_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001678 0.60 1.00 0.82 1

204311_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  ATP1B2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GTCTCTCTCT

SOURCE GeneReport for Unigene cluster: Hs.712542

Expression variation in blood from EXPOLDB for ATP1B2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for ATP1B2 gene from 5/9 species (see all 9 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
ATP1B21   -- ATPase, Na+/K+ transporting, beta 2 polypeptide 94.14(n)
98.62(a)
489479  XM_546597.2  XP_546597.2 
chimpanzee
(Pan troglodytes)
ATP1B21   -- ATPase, Na+/K+ transporting, beta 2 polypeptide 99.66(n)
100(a)
749043  XM_001171979.1  XP_001171979.1 
cow
(Bos taurus)
ATP1B21   -- ATPase, Na+/K+ transporting, beta 2 polypeptide 93.68(n)
97.93(a)
282562  NM_174677.2  NP_777102.1 
rat
(Rattus norvegicus)
Atp1b21   -- ATPase, Na+/K+ transporting, beta 2 polypeptide 91.12(n)
97.92(a)
24214  NM_012507.2  NP_036639.2 
mouse
(Mus musculus)
Atp1b21, 5 11 (40.00 cM)5
ATPase, Na+/K+ transporting, beta 2 polypeptide1, 5 90.92(n)1
97.24(a)1
119321  NM_013415.41  NP_038201.11 
 AI8429965  AK1417865  (see all 12)
About this table        Species with no ortholog for ATP1B2

ENSEMBL Gene Tree for ATP1B2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for ATP1B2 gene
ATP1B12  ATP1B32  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/57 NCBI SNPs in ATP1B2 are shown (see all 57 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 39)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs16415101,2
A,C,F,H7502221(-) ACAGGT/CTCTCT 1 -- ng317Minor allele frequency- C:0.44EA NA EU WA 478
rs10505401,2
A,C,F,H7501467(+) GCCCAC/TAGAAT 1 -- ut31 ese39Minor allele frequency- T:0.25MN EU EA WA 1020
rs16427621,2
A,C,F,H7495497(+) TTCAGC/TGCGCG 1 -- ut51 ese35Minor allele frequency- T:0.45MN EU EA WA 596
--
rs10505331,2
A,C,F,H7501019(+) gcgccC/TggccT 1 -- ut31 ese35Minor allele frequency- T:0.38MN EU EA WA 594
rs10505411,2
A,C,F,H7501560(+) TTCACG/TTCCTC 1 -- ut31 ese37Minor allele frequency- T:0.44MN EU EA WA NA 786
rs16415111,2
A,C,F,H7500402(-) GTGGCT/CAGAGC 1 -- ut31 ese310Minor allele frequency- C:0.35EA MN EU WA NA 1708
rs16240851,2
A,C,F7494468(+) GGGTGG/CCCTTT 1 -- ng51 tfbs39Minor allele frequency- C:0.44EA NA MN CSAM 634
rs16415131,2
A,C,F7494967(-) GTGCGG/AGGCCC 1 -- ng511Minor allele frequency- A:0.06MN 184
--
rs10505281,2
A,C,F7495261(+) TTTGGC/G/TGGGGG 1 -- ut51 ese36MN CSAM EA 592
rs16415121,2
A,C,F7500187(-) TCCTCT/CGTGGC 1 -- ut31 ese311Minor allele frequency- C:0.32EA MN NA CSAM 2450
About this table

HapMap Linkage Disequilibrium images for ATP1B2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 182331

Human Genome Epidemiology Navigator: ATP1B2 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/25 PubMed articles for ATP1B2 gene (see all 25 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 482 HGNC: 805 AceView: ATP1B2 Ensembl:ENSG00000129244 euGenes: HUgn482
ECgene: ATP1B2 H-InvDB: ATP1B2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for ATP1B2 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

Licensable Technologies for ATP1B2 gene:
 Weizmann Institute:"Na, K-ATPase Isoforms and Selective Inhibitors Thereof"

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for ATP1B2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ATP1B2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for ATP1B2 Antibodies for ATP1B2
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for ATP1B2 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (ATP1B2)
 Antibodies (ATP1B2)
 Chimera RNAi (ATP1B2)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(ATPase Na+/ K+ beta 2)
 Antibodies (ATPase Na+/ K+ beta 2)
 Search OriGene for ATP1B2
 Tocris compounds for ATP1B2




 Drugs for ATP1B2
 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for ATP1B2

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