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Aliases for ATP1B1 Gene

Aliases for ATP1B1 Gene

  • ATPase, Na+/K+ Transporting, Beta 1 Polypeptide 2 3
  • Sodium-Potassium ATPase Subunit Beta 1 (Non-Catalytic) 2 3
  • Sodium/Potassium-Transporting ATPase Subunit Beta-1 2 3
  • Sodium Pump Subunit Beta-1 2 3
  • ATP1B 3 4
  • Sodium/Potassium-Transporting ATPase Beta-1 Chain 3
  • Sodium/Potassium-Dependent ATPase Beta-1 Subunit 3
  • Sodium/Potassium-Dependent ATPase Subunit Beta-1 4
  • Beta 1-Subunit Of Na(+),K(+)-ATPase 3
  • Na, K-ATPase Beta-1 Polypeptide 3
  • Adenosinetriphosphatase 3

External Ids for ATP1B1 Gene

Previous Symbols for ATP1B1 Gene

  • ATP1B

Summaries for ATP1B1 Gene

Entrez Gene Summary for ATP1B1 Gene

  • The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

GeneCards Summary for ATP1B1 Gene

ATP1B1 (ATPase, Na+/K+ Transporting, Beta 1 Polypeptide) is a Protein Coding gene. Diseases associated with ATP1B1 include thyrotoxic periodic paralysis and megalencephalic leukoencephalopathy with subcortical cysts. Among its related pathways are Hemostasis and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1B3.

UniProtKB/Swiss-Prot for ATP1B1 Gene

  • This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

  • Involved in cell adhesion and establishing epithelial cell polarity.

Tocris Summary for ATP1B1 Gene

  • Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients across the plasma membrane.

Gene Wiki entry for ATP1B1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP1B1 Gene

Genomics for ATP1B1 Gene

Genomic Location for ATP1B1 Gene

Start:
169,105,697 bp from pter
End:
169,132,722 bp from pter
Size:
27,026 bases
Orientation:
Plus strand

Genomic View for ATP1B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP1B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1B1 Gene

Regulatory Elements for ATP1B1 Gene

Proteins for ATP1B1 Gene

  • Protein details for ATP1B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05026-AT1B1_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1
    Protein Accession:
    P05026
    Secondary Accessions:
    • Q5TGZ3

    Protein attributes for ATP1B1 Gene

    Size:
    303 amino acids
    Molecular mass:
    35061 Da
    Quaternary structure:
    • Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with NKAIN1, NKAIN2 and NKAIN4 (By similarity). Interacts with MLC1. Part of a complex containing MLC1, TRPV4, AQP4 and HEPACAM.

    Alternative splice isoforms for ATP1B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP1B1 Gene

Proteomics data for ATP1B1 Gene at MOPED

Post-translational modifications for ATP1B1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn158, Asn193, and Asn265

Other Protein References for ATP1B1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ATP1B1 Gene

Domains for ATP1B1 Gene

Gene Families for ATP1B1 Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

Protein Domains for ATP1B1 Gene

UniProtKB/Swiss-Prot:

AT1B1_HUMAN
Domain:
  • The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.:
    • P05026
Family:
  • Belongs to the X(+)/potassium ATPases subunit beta family.:
    • P05026
genes like me logo Genes that share domains with ATP1B1: view

Function for ATP1B1 Gene

Molecular function for ATP1B1 Gene

GENATLAS Biochemistry: ATPase,Na+K+,beta 1 polypeptide,expressed in neurons,containing a CCG repeat in 5utr
UniProtKB/Swiss-Prot Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
UniProtKB/Swiss-Prot Function: Involved in cell adhesion and establishing epithelial cell polarity.

Gene Ontology (GO) - Molecular Function for ATP1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001671 ATPase activator activity IDA 10636900
GO:0005391 contributes_to sodium:potassium-exchanging ATPase activity IDA 10636900
GO:0005515 protein binding IPI 17947299
GO:0023026 MHC class II protein complex binding IDA 20458337
GO:0051117 ATPase binding IPI 10636900
genes like me logo Genes that share ontologies with ATP1B1: view
genes like me logo Genes that share phenotypes with ATP1B1: view

miRNA for ATP1B1 Gene

miRTarBase miRNAs that target ATP1B1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP1B1 Gene

Localization for ATP1B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1B1 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP1B1 Gene COMPARTMENTS Subcellular localization image for ATP1B1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ATP1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IDA 10636900
GO:0005901 caveola IEA --
GO:0014704 intercalated disc ISS --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with ATP1B1: view

Pathways for ATP1B1 Gene

genes like me logo Genes that share pathways with ATP1B1: view

Gene Ontology (GO) - Biological Process for ATP1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006813 potassium ion transport --
GO:0006814 sodium ion transport --
GO:0006874 cellular calcium ion homeostasis ISS --
genes like me logo Genes that share ontologies with ATP1B1: view

Compounds for ATP1B1 Gene

(2) Tocris Compounds for ATP1B1 Gene

Compound Action Cas Number
Digoxin Na+, K+-ATPase inhibitor [20830-75-5]
Lithium carbonate Mood stabilizer; inhibits Na+/K+ ATPase pump activity [554-13-2]

(7) HMDB Compounds for ATP1B1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
Phosphate
  • NFB Orthophosphate
14265-44-2
Potassium
  • K+
7440-09-7

(9) Novoseek inferred chemical compound relationships for ATP1B1 Gene

Compound -log(P) Hits PubMed IDs
adp 56.9 3
atp 46.9 6
phosphocreatine 43.4 2
adenylate 23.9 2
magnesium 19.4 2
genes like me logo Genes that share compounds with ATP1B1: view

Transcripts for ATP1B1 Gene

mRNA/cDNA for ATP1B1 Gene

Unigene Clusters for ATP1B1 Gene

ATPase, Na+/K+ transporting, beta 1 polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1B1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2:
SP3: - - - - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7: - - - -

Relevant External Links for ATP1B1 Gene

GeneLoc Exon Structure for
ATP1B1
ECgene alternative splicing isoforms for
ATP1B1

Expression for ATP1B1 Gene

mRNA expression in normal human tissues for ATP1B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP1B1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP1B1 Gene

SOURCE GeneReport for Unigene cluster for ATP1B1 Gene Hs.291196

mRNA Expression by UniProt/SwissProt for ATP1B1 Gene

P05026-AT1B1_HUMAN
Tissue specificity: Found in most tissues
genes like me logo Genes that share expressions with ATP1B1: view

Orthologs for ATP1B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP1B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP1B1 36
  • 99.12 (n)
  • 99.67 (a)
ATP1B1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP1B1 36
  • 88.08 (n)
  • 86.99 (a)
ATP1B1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP1B1 36
  • 89.33 (n)
  • 93.07 (a)
ATP1B1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp1b1 36
  • 88.78 (n)
  • 94.06 (a)
Atp1b1 16
Atp1b1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP1B1 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP1B1 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp1b1 36
  • 89.22 (n)
  • 95.05 (a)
chicken
(Gallus gallus)
Aves ATP1B1 36
  • 71.73 (n)
  • 71.29 (a)
ATP1B1 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP1B1 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia atp1b1a-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia atp1b1 36
  • 67 (n)
  • 65.89 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10571 36
zebrafish
(Danio rerio)
Actinopterygii atp1b1a 36
atp1b1a 37
  • 58 (a)
OneToMany
atp1b1b 36
  • 61.17 (n)
  • 59.6 (a)
atp1b1b 37
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009595 36
  • 45.91 (n)
  • 36.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta nrv1 37
  • 29 (a)
ManyToMany
nrv2 37
  • 23 (a)
ManyToMany
nrv3 36
  • 47.05 (n)
  • 35.38 (a)
nrv3 37
  • 28 (a)
ManyToMany
Nrv1 38
  • 33 (a)
CG8663 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea nkb-1 37
  • 26 (a)
ManyToMany
nkb-3 37
  • 28 (a)
ManyToMany
F55F3.3 38
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10387 37
  • 27 (a)
OneToMany
Species with no ortholog for ATP1B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP1B1 Gene

ENSEMBL:
Gene Tree for ATP1B1 (if available)
TreeFam:
Gene Tree for ATP1B1 (if available)

Paralogs for ATP1B1 Gene

Paralogs for ATP1B1 Gene

Selected SIMAP similar genes for ATP1B1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ATP1B1 Gene

genes like me logo Genes that share paralogs with ATP1B1: view

Variants for ATP1B1 Gene

Sequence variations from dbSNP and Humsavar for ATP1B1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1420 -- 169,112,252(+) ACTTG(A/G)GTGCC intron-variant
rs16631 -- 169,122,683(+) ATTTC(-/TA)TCACT intron-variant
rs754549 -- 169,118,726(-) AATTT(A/T)AAAAA intron-variant
rs754550 -- 169,118,682(-) CACGT(A/G)TATGT intron-variant
rs754551 -- 169,118,549(-) CTGTG(A/G)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP1B1 Gene

Variant ID Type Subtype PubMed ID
nsv831858 CNV Gain 17160897
esv22143 CNV Gain+Loss 19812545
esv2719339 CNV Deletion 23290073

Relevant External Links for ATP1B1 Gene

HapMap Linkage Disequilibrium report
ATP1B1
Human Gene Mutation Database (HGMD)
ATP1B1

Disorders for ATP1B1 Gene

(1) OMIM Diseases for ATP1B1 Gene (182330)

Relevant External Links for ATP1B1

Genetic Association Database (GAD)
ATP1B1
Human Genome Epidemiology (HuGE) Navigator
ATP1B1
genes like me logo Genes that share disorders with ATP1B1: view

No data available for UniProtKB/Swiss-Prot for ATP1B1 Gene

Publications for ATP1B1 Gene

  1. Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes. (PMID: 16430714) Kung A.W. … Chan V. (Clin. Endocrinol. (Oxf) 2006) 3 23 49
  2. Molecular cloning and sequence analysis of human Na,K-ATPase beta- subunit. (PMID: 3008098) Kawakami K. … Nagano K. (Nucleic Acids Res. 1986) 3 4
  3. Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium. (PMID: 7536695) Ruiz A. … Bok D. (Gene 1995) 3 4
  4. Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress. (PMID: 17947299) Zatyka M. … Barrett T.G. (Hum. Mol. Genet. 2008) 3 23
  5. Human Na(+), K(+)-ATPase genes. Beta subunit gene family contains at least one gene and one pseudogene. (PMID: 2555225) Ushkaryov Y.A. … Sverdlov E.D. (FEBS Lett. 1989) 3 4

Products for ATP1B1 Gene

Sources for ATP1B1 Gene

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