Aliases for ATP1B1 Gene
- ATPase Na+/K+ Transporting Subunit Beta 1 2 3
- ATPase, Na+/K+ Transporting, Beta 1 Polypeptide 2 3 5
- Sodium-Potassium ATPase Subunit Beta 1 (Non-Catalytic) 2 3
- Sodium Pump Subunit Beta-1 2 3
- ATP1B 3 4
- Sodium/Potassium-Transporting ATPase Subunit Beta-1 2
- Sodium/Potassium-Transporting ATPase Beta-1 Chain 3
External Ids for ATP1B1 Gene
Previous HGNC Symbols for ATP1B1 Gene
Previous GeneCards Identifiers for ATP1B1 Gene
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]
GeneCards Summary for ATP1B1 Gene
ATP1B1 (ATPase Na+/K+ Transporting Subunit Beta 1) is a Protein Coding gene. Diseases associated with ATP1B1 include thyrotoxic periodic paralysis and megalencephalic leukoencephalopathy with subcortical cysts. Among its related pathways are cGMP-PKG signaling pathway and Aldosterone-regulated sodium reabsorption. GO annotations related to this gene include ATPase binding and ATPase activator activity. An important paralog of this gene is ATP1B3.
UniProtKB/Swiss-Prot for ATP1B1 Gene
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Involved in cell adhesion and establishing epithelial cell polarity.
The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.