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Aliases for ATP1A4 Gene

Aliases for ATP1A4 Gene

  • ATPase Na+/K+ Transporting Subunit Alpha 4 2 3
  • ATPase, Na+/K+ Transporting, Alpha 4 Polypeptide 2 3 5
  • Sodium Pump Subunit Alpha-4 2 3 4
  • ATPase, Na+/K+ Transporting, Alpha Polypeptide-Like 2 2 3
  • Sodium-Potassium ATPase Catalytic Subunit Alpha-4 2 3
  • Na(+)/K(+) ATPase Alpha-4 Subunit 3 4
  • EC 3.6.3.9 4 63
  • ATP1AL2 3 4
  • Sodium/Potassium-Transporting ATPase Subunit Alpha-4 2
  • Sodium/Potassium-Transporting ATPase Alpha-4 Chain 3
  • Na+/K+ ATPase, Alpha-D Polypeptide 3
  • Na,K-ATPase Subunit Alpha-C 3
  • Na+/K+ ATPase 4 3
  • Sodium Pump 4 3
  • EC 3.6.3 63
  • ATP1A1 3

External Ids for ATP1A4 Gene

Previous HGNC Symbols for ATP1A4 Gene

  • ATP1AL2

Previous GeneCards Identifiers for ATP1A4 Gene

  • GC01U990013
  • GC01P155853
  • GC01P156899
  • GC01P157338
  • GC01P156934
  • GC01P158387
  • GC01P160121
  • GC01P131478

Summaries for ATP1A4 Gene

Entrez Gene Summary for ATP1A4 Gene

  • The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP1A4 Gene

ATP1A4 (ATPase Na+/K+ Transporting Subunit Alpha 4) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Bile secretion. GO annotations related to this gene include nucleotide binding and sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP12A.

UniProtKB/Swiss-Prot for ATP1A4 Gene

  • This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.

Tocris Summary for ATP1A4 Gene

  • The Na+/K+ ATPase is a membrane protein that is composed of two subunits - alpha and beta. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions.

Gene Wiki entry for ATP1A4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP1A4 Gene

Genomics for ATP1A4 Gene

Regulatory Elements for ATP1A4 Gene

Genomic Location for ATP1A4 Gene

Chromosome:
1
Start:
160,151,562 bp from pter
End:
160,186,977 bp from pter
Size:
35,416 bases
Orientation:
Plus strand

Genomic View for ATP1A4 Gene

Genes around ATP1A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP1A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP1A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1A4 Gene

Proteins for ATP1A4 Gene

  • Protein details for ATP1A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13733-AT1A4_HUMAN
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-4
    Protein Accession:
    Q13733
    Secondary Accessions:
    • Q504T2
    • Q7Z4I9
    • Q8TBN8
    • Q8WXA7
    • Q8WXH7
    • Q8WY13

    Protein attributes for ATP1A4 Gene

    Size:
    1029 amino acids
    Molecular mass:
    114166 Da
    Quaternary structure:
    • Composed of three subunits: alpha (catalytic), beta and gamma.
    SequenceCaution:
    • Sequence=AAQ07964.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05228.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP1A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP1A4 Gene

Proteomics data for ATP1A4 Gene at MOPED

Post-translational modifications for ATP1A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP1A4 Gene

Domains & Families for ATP1A4 Gene

Gene Families for ATP1A4 Gene

Suggested Antigen Peptide Sequences for ATP1A4 Gene

Graphical View of Domain Structure for InterPro Entry

Q13733

UniProtKB/Swiss-Prot:

AT1A4_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
genes like me logo Genes that share domains with ATP1A4: view

Function for ATP1A4 Gene

Molecular function for ATP1A4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by an endogenous cardiac glycoside, ouabain.
UniProtKB/Swiss-Prot Function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.

Enzyme Numbers (IUBMB) for ATP1A4 Gene

genes like me logo Genes that share phenotypes with ATP1A4: view

Animal Models for ATP1A4 Gene

MGI Knock Outs for ATP1A4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP1A4

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATP1A4 Gene

Localization for ATP1A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1A4 Gene

Cell membrane; Multi-pass membrane protein. Note=In mature sperm, located in the principle piece of the sperm flagellum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP1A4 Gene COMPARTMENTS Subcellular localization image for ATP1A4 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for ATP1A4 Gene

Pathways & Interactions for ATP1A4 Gene

genes like me logo Genes that share pathways with ATP1A4: view

Gene Ontology (GO) - Biological Process for ATP1A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport TAS 7809153
GO:0006883 cellular sodium ion homeostasis IBA --
GO:0007283 spermatogenesis IEA --
GO:0008152 metabolic process IEA --
GO:0009566 fertilization IEA --
genes like me logo Genes that share ontologies with ATP1A4: view

No data available for SIGNOR curated interactions for ATP1A4 Gene

Drugs & Compounds for ATP1A4 Gene

(5) Drugs for ATP1A4 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Lansoprazole Approved, Investigational Pharma H+,K+-ATPase inhibitor 198
Omeprazole Approved, Investigational Pharma Activator H+,K+-ATPase inhibitor 321
Potassium Experimental Pharma 0
Magnesium Nutra 0

(6) Additional Compounds for ATP1A4 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
sodium
  • Sodium
  • Sodium ion
7440-23-5
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
PF 3716556
928774-43-0
genes like me logo Genes that share compounds with ATP1A4: view

Transcripts for ATP1A4 Gene

Unigene Clusters for ATP1A4 Gene

ATPase, Na+/K+ transporting, alpha 4 polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1A4 Gene

No ASD Table

Relevant External Links for ATP1A4 Gene

GeneLoc Exon Structure for
ATP1A4
ECgene alternative splicing isoforms for
ATP1A4

Expression for ATP1A4 Gene

mRNA expression in normal human tissues for ATP1A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP1A4 Gene

This gene is overexpressed in Testis (x23.9) and Bladder (x5.4).

Protein differential expression in normal tissues from HIPED for ATP1A4 Gene

This gene is overexpressed in Brain (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP1A4 Gene



SOURCE GeneReport for Unigene cluster for ATP1A4 Gene Hs.662219

mRNA Expression by UniProt/SwissProt for ATP1A4 Gene

Q13733-AT1A4_HUMAN
Tissue specificity: Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature sperm (at protein level).
genes like me logo Genes that share expression patterns with ATP1A4: view

Protein tissue co-expression partners for ATP1A4 Gene

Primer Products

In Situ Assay Products

Orthologs for ATP1A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP1A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP1A4 36
  • 98 (a)
OneToOne
ATP1A4 35
  • 99.39 (n)
  • 99.09 (a)
cow
(Bos Taurus)
Mammalia ATP1A4 35
  • 87.07 (n)
  • 86.49 (a)
ATP1A4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP1A4 36
  • 86 (a)
OneToOne
ATP1A4 35
  • 84.87 (n)
  • 85.81 (a)
mouse
(Mus musculus)
Mammalia Atp1a4 16
Atp1a4 36
  • 83 (a)
OneToOne
Atp1a4 35
  • 82.31 (n)
  • 83.8 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Atp1a4 35
  • 82.94 (n)
  • 83.46 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii atp1a2a 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Atpalpha 36
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eat-6 36
  • 70 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENA1 36
  • 27 (a)
ManyToMany
ENA2 36
  • 27 (a)
ManyToMany
ENA5 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToMany
Species with no ortholog for ATP1A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATP1A4 Gene

ENSEMBL:
Gene Tree for ATP1A4 (if available)
TreeFam:
Gene Tree for ATP1A4 (if available)

Paralogs for ATP1A4 Gene

Paralogs for ATP1A4 Gene

(7) SIMAP similar genes for ATP1A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP1A4: view

Variants for ATP1A4 Gene

Sequence variations from dbSNP and Humsavar for ATP1A4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6427504 - 160,155,085(+) TCGAG(A/G/T)TGGAC reference, missense
rs17368402 - 160,164,266(+) AGATC(A/G)AACAC reference, missense
rs16831482 - 160,171,381(+) TGAAA(G/T)GAAGG reference, missense
rs7528360 - 160,171,661(+) CCCAT(A/G)GACAA reference, missense
rs669162 -- 160,171,495(+) TTATC(C/T)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP1A4 Gene

Variant ID Type Subtype PubMed ID
nsv872490 CNV Loss 21882294
nsv520399 CNV Loss 19592680
nsv522918 CNV Loss 19592680
nsv819332 CNV Loss 19587683

Variation tolerance for ATP1A4 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP1A4 Gene

HapMap Linkage Disequilibrium report
ATP1A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP1A4 Gene

Disorders for ATP1A4 Gene

Relevant External Links for ATP1A4

Genetic Association Database (GAD)
ATP1A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP1A4

No disorders were found for ATP1A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP1A4 Gene

Publications for ATP1A4 Gene

  1. The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm. (PMID: 16175638) Hlivko J.T. … James P.F. (Mol. Reprod. Dev. 2006) 3 4 67
  2. The transcription factor CREMtau and cAMP regulate promoter activity of the Na,K-ATPase alpha4 isoform. (PMID: 16894555) Rodova M. … Blanco G. (Mol. Reprod. Dev. 2006) 3 23
  3. A detailed multipoint gene map of chromosome 1q. (PMID: 1981991) Buetow K.H. … Murray J.C. (Genomics 1990) 2 3
  4. Multiple genes encode the human Na+,K+-ATPase catalytic subunit. (PMID: 3035563) Shull M.M. … Lingrel J.B. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ATP1A4 Gene

Sources for ATP1A4 Gene

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