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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP1A4 Gene

protein-coding   GIFtS: 57
GCID: GC01P160121

ATPase, Na+/K+ transporting, alpha 4 polypeptide

(Previous names: ATPase, Na+/K+ transporting, alpha polypeptide-like 2 )
(Previous symbol: ATP1AL2)
 Explore 7 diseases affiliated with
ATP1A4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATP1A4    

Aliases
for ATP1A4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATPase, Na+/K+ Transporting, Alpha 4 Polypeptide1 2     Na+/K+ ATPase, Alpha-D Polypeptide2
ATP1AL21 2 3 5     Na,K-ATPase Subunit Alpha-C2
ATPase, Na+/K+ Transporting, Alpha Polypeptide-Like 21 2     Sodium Pump 42
Sodium Pump Subunit Alpha-42 3     Sodium-Potassium ATPase Catalytic Subunit Alpha-42
Na(+)/K(+) ATPase Alpha-4 Subunit2 3     Sodium/Potassium-Transporting ATPase Alpha-4 Chain2
EC 3.6.3.93 8     Sodium/Potassium-Transporting ATPase Subunit Alpha-42
ATP1A12     EC 3.6.38
Na+/K+ ATPase 42     

External Ids:    HGNC: 140731   Entrez Gene: 4802   Ensembl: ENSG000001326817   OMIM: 6073215   UniProtKB: Q137333   

Export aliases for ATP1A4 gene to outside databases

Previous GC identifers: GC01U990013 GC01P155853 GC01P156899 GC01P157338 GC01P156934 GC01P158387 GC01P131478


Summaries
for ATP1A4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ATP1A4:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of
Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the
electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for
osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical
excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a
smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene
encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AT1A4_HUMAN, Q13733
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the
exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of
sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm
motility

summary for ATP1A4:
Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients
across the plasma membrane.

Gene Wiki entry for ATP1A4


Genomic Views
for ATP1A4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP1A4 gene promoter:
         AhR   HTF   Nkx5-1   Arnt   Evi-1   AREB6   Pax-3   HNF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP1A4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP1A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP1A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

ATP1A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP1A4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P160121:  view genomic region     (about GC identifiers)

Start:
 160,121,352 bp from pter      End:
 160,156,767 bp from pter
Size:
 35,416 bases      Orientation:
 plus strand

Proteins
for ATP1A4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AT1A4_HUMAN, Q13733 (See protein sequence)
Recommended Name: Sodium/potassium-transporting ATPase subunit alpha-4  
Size: 1029 amino acids; 114166 Da
Subunit: Composed of three subunits: alpha (catalytic), beta and gamma
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=In mature sperm, located in the principle piece
of the sperm flagellum
Sequence caution: Sequence=AAQ07964.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC05228.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q504T2 Q7Z4I9 Q8TBN8 Q8WXA7 Q8WXH7 Q8WY13
Alternative splicing: 2 isoforms:  Q13733-1   Q13733-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP1A4: NX_Q13733

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13733

    • 4/54 DME Specific Peptides for ATP1A4 (Q13733) (see all 54)
     QLFGGFS  AVETLGS  DDNFASI  VGIISEG 

    ATP1A4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001734.1  NP_653300.2  

    ENSEMBL proteins: 
     ENSP00000357060   ENSP00000434272   ENSP00000433094  
    Reactome Protein details: Q13733
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS7809153
    GO:0005890sodium:potassium-exchanging ATPase complex TAS7809153
    GO:0016021integral to membrane ----


    ATP1A4 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ATP1A4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATP1A4 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR023298 ATPase_P-typ_TM_dom
     IPR023306 ATPase_cation_domN
     IPR005775 ATPase_P-typ_Na/K
     IPR023299 ATPase_P-typ_cyto_domN
     IPR008250 ATPase_P-typ_transduc_dom_A

    Graphical View of Domain Structure for InterPro Entry Q13733

    ProtoNet protein and cluster: Q13733

    4 Blocks protein families:
    IPB001757 ATPase
    IPB006068 Cation transporting ATPase
    IPB006069 Sodium/potassium-transporting ATPase signature
    IPB008250 E1-E2 ATPase-associated region


    UniProtKB/Swiss-Prot: AT1A4_HUMAN, Q13733
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily


    Function
    for ATP1A4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AT1A4_HUMAN, Q13733
    Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the
    exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of
    sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm
    motility
    Catalytic activity: ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In)
    Enzyme regulation: Specifically inhibited by an endogenous cardiac glycoside, ouabain

    Enzyme Numbers (IUBMB): EC 3.6.3.91 2 EC 3.6.32

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005391sodium:potassium-exchanging ATPase activity TAS7809153
    GO:0005524ATP binding IEA--
    GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism ----
    GO:0046872metal ion binding IEA--


    ATP1A4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Atp1a4tm1Itl for ATP1A4
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Atp1a4):
     reproductive system 

    ATP1A4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATP1A4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Ion transport by P-type ATPases0.32
    2Gastric acid secretion
    		Gastric acid secretion1.00
    		Salivary secretion0.35
    3Sodium-coupled transporters and pumps
    		Sodium-coupled transporters and pumps1.00
    4Hepatic ABC Transporters
    		Hepatic ABC Transporters1.00
    5Mineral absorption
    		Mineral absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ATP1A4
        Sodium-coupled transporters and pumps

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATP1A4
        Hepatic ABC Transporters
    Aldosterone Signaling in Epithelial Cells

    1 BioSystems Pathway for ATP1A4 
        Calcium Regulation in the Cardiac Cell

    3        Reactome Pathways for ATP1A4
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases


    5/11         Kegg Pathways  (Kegg details for ATP1A4) (see all 11):
        Cardiac muscle contraction
    Aldosterone-regulated sodium reabsorption
    Endocrine and other factor-regulated calcium reabsorption
    Proximal tubule bicarbonate reclamation
    Salivary secretion


    ATP1A4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATP1A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for ATP1A4 (Q137333 ENSP000003570604) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    YWHABP319463I2D: score=1 
    ATP1A1ENSP000002955984STRING: ENSP00000295598
    ATP1A2ENSP000003544904STRING: ENSP00000354490
    ATP1A3ENSP000003023974STRING: ENSP00000302397
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006754ATP biosynthetic process IEA--
    GO:0006812cation transport ----
    GO:0006813potassium ion transport TAS7809153
    GO:0006814sodium ion transport TAS7809153
    GO:0007283spermatogenesis IEA--


    ATP1A4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATP1A4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for ATP1A4:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ATP1A4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Ouabain Na+,K+-ATPase inhibitor [630-60-4]
    Digoxin Na+,K+-ATPase inhibitor [20830-75-5]

    7 HMDB Compounds for ATP1A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    PotassiumK+ (see all 16)7440-09-7--
    SodiumSodium (see all 2)7440-23-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about ATP1A4 / AT1A4 

    Transcripts
    for ATP1A4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATP1A4 gene (2 alternative transcripts): 
    NM_001001734.1  NM_144699.3  

    Unigene Cluster for ATP1A4:

    ATPase, Na+/K+ transporting, alpha 4 polypeptide
    Hs.662219  [show with all ESTs]
    Unigene Representative Sequence: NM_144699
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368081(uc001fve.4) ENST00000477338(uc001fvf.4) ENST00000469023(uc001fvg.3)
    ENST00000418334 ENST00000466526 ENST00000470705(uc001fvh.3)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATP1A4:
    hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmid: ATP1A4 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF459737.1 AF506797.1 AK098076.1 AK308286.1 AL833335.1 BC028297.1 BC036052.1 BC068570.1 
    BC094801.1 BX647234.1 M16796.1 

    5 DOTS entries:

    DT.101984611  DT.100768176  DT.100806889  DT.92058354  DT.101984609 

    24/25 AceView cDNA sequences (see all 25):

    AL705562 M16796 BG260350 NM_001001734 CR605608 AA383352 NM_144699 BC028297 
    AF459737 AK125812 CB991485 BI560630 BC068570 BX647234 AF506797 AK098076 
    BX359636 BX402599 AL833335 BC036052 BG721910 BI462517 BI462650 BG722324 

    GeneLoc Exon Structure


    Expression
    for ATP1A4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP1A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCAGAGGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ATP1A4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ATP1A4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP1A4

    SOURCE GeneReport for Unigene cluster: Hs.662219

    UniProtKB/Swiss-Prot: AT1A4_HUMAN, Q13733
    Tissue specificity: Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in mature
    sperm (at protein level)

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    In Situ
    Assay Products:     
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    Orthologs
    for ATP1A4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ATP1A4 gene from 3/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 76(a)
    74(a)
    		 1 ↔ many
    1 ↔ many
    		 GL343393.1(216948-220013)
    GL343393.1(232606-235668)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Atpalpha6
    JYalpha6
    (see all 4)    		 JYalpha
    (see all 4)    		 69(a)
    67(a)
    (see all 4)    		 1 ↔ many
    possible ortholog
    (see all 4)    		 3R(16774436-16801961)
    4(24053-25665)
    worm
    (Caenorhabditis elegans)    		 Secernentea eat-66
    catp-46
    (see all 5)    		 --
    		 70(a)
    52(a)
    (see all 5)    		 1 ↔ many
    possible ortholog
    (see all 5)    		 V(13126392-13129982)
    II(14593449-14597565)


    ENSEMBL Gene Tree for ATP1A4 (if available)
    TreeFam Gene Tree for ATP1A4 (if available) 

    Paralogs
    for ATP1A4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP1A4 gene
    ATP2C12  ATP2A32  ATP1A22  ATP2C22  ATP2A12  ATP4A2  ATP1A32  ATP2A22  
    ATP12A2  ATP1A12  
    8 SIMAP similar genes for ATP1A4 using alignment to 2 protein entries:     AT1A4_HUMAN (see all proteins):
    ATP1A2    ATP1A3    ATP1A1    DKFZp666G172    ATP4A    ATP12A
    ATP2A2    ATP2C1

    ATP1A4 for paralogs           About GeneDecksing



    Genomic Variants
    for ATP1A4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/857 NCBI SNPs in ATP1A4 are shown (see all 857)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1115406391,2
    		--160119448(+) TACCTC/TCTTTT 1 -- us2k12Minor allele frequency- T:0.02CSA WA 120
    rs1429132201,2
    		--160119541(+) AGAATC/GTGAGT 1 -- us2k10--------
    rs564037101,2
    		C,--160119684(+) TCAAGA/GAGGAT 1 -- us2k10--------
    rs1474391081,2
    		--160119776(+) ATCAGG/TCCAGG 1 -- us2k10--------
    rs112653331,2
    		C,F,A,H,--160119778(+) CAGGCC/TAGGCT 1 -- us2k110Minor allele frequency- T:0.24NS EA NA WA 750
    rs1151748631,2
    		F,--160119884(+) CACCCC/TGTCTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs112653341,2
    		C,A,H,--160119908(+) TAAAAA/TAAATT 1 -- us2k17Minor allele frequency- T:0.19NA CSA WA EA 367
    rs115785221,2
    		C,F,A,H,--160120015(+) ATAATC/TGCACC 1 -- us2k113Minor allele frequency- T:0.26NS EA NA WA CSA 785
    rs1155587181,2
    		F,--160120094(+) CAGAAT/CGGGAA 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1396493801,2
    		--160120208(+) AAAACA/GTATAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATP1A4 (160121352 - 160156767 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ATP1A4
         1 CNV: 58341

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    Disorders / Diseases
    for ATP1A4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATP1A4 for disorders           About GeneDecksing

    OMIM gene information: 607321    OMIM disorders: --

    7 diseases for ATP1A4:    About MalaCards
    diabetic neuropathy    aldosteronism    pharyngitis    neuropathy
    hypertension    pancreatitis    malaria


    Export disorders for ATP1A4 gene to outside databases

    Publications
    for ATP1A4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP1A4 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with ATP1A4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm. (PubMed id 16175638)1, 2 Hlivko J.T.... James P.F. (2006)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4. (PubMed id 12119109)1, 2 Keryanov S. and Gardner K.L. (2002)
    6. A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. (PubMed id 7809153)1, 2 Shamraj O.I. and Lingrel J.B. (1994)
    7. A detailed multipoint gene map of chromosome 1q. (PubMed id 1981991)1, 3 Buetow K.H....Murray J.C. (1990)
    8. Multiple genes encode the human Na+,K+-ATPase catalytic subunit. (PubMed id 3035563)1, 3 Shull M.M. and Lingrel J.B. (1987)
    9. The transcription factor CREMtau and cAMP regulate promoter activity of the Na,K-ATPase alpha4 isoform. (PubMed id 16894555)1, 9 Rodova M....Blanco G. (2006)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for ATP1A4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ATP1A4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 480 HGNC: 14073 AceView: ATP1A4 Ensembl:ENSG00000132681 euGenes: HUgn480
    ECgene: ATP1A4 Kegg: 480 H-InvDB: ATP1A4

    Other Databases showing ATP1A4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATP1A4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP1A4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATP1A4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATP1A4 gene:
    Search GeneIP for patents involving ATP1A4

    Licensable Technologies for ATP1A4 gene:
    Weizmann Institute:"Na, K-ATPase Isoforms and Selective Inhibitors Thereof"
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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