Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ATP1A4 Gene

protein-coding   GIFtS: 60
GCID: GC01P160121

ATPase, Na+/K+ Transporting, Alpha 4 Polypeptide

(Previous names: ATPase, Na+/K+ transporting, alpha polypeptide-like 2)
(Previous symbol: ATP1AL2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ATPase, Na+/K+ Transporting, Alpha 4 Polypeptide1 2     ATP1A12
ATP1AL21 2 3 5     Na+/K+ ATPase 42
Sodium Pump Subunit Alpha-41 2 3     Na+/K+ ATPase, Alpha-D Polypeptide2
ATPase, Na+/K+ Transporting, Alpha Polypeptide-Like 21 2     Na,K-ATPase Subunit Alpha-C2
Sodium-Potassium ATPase Catalytic Subunit Alpha-41 2     Sodium Pump 42
Sodium/Potassium-Transporting ATPase Subunit Alpha-41 2     Sodium/Potassium-Transporting ATPase Alpha-4 Chain2
Na(+)/K(+) ATPase Alpha-4 Subunit2 3     EC 3.6.38
EC 3.6.3.93 8     

External Ids:    HGNC: 140731   Entrez Gene: 4802   Ensembl: ENSG000001326817   OMIM: 6073215   UniProtKB: Q137333   

Export aliases for ATP1A4 gene to outside databases

Previous GC identifers: GC01U990013 GC01P155853 GC01P156899 GC01P157338 GC01P156934 GC01P158387 GC01P131478


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ATP1A4 Gene:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of
Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the
electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for
osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical
excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and
a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This
gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for ATP1A4 Gene:
ATP1A4 (ATPase, Na+/K+ transporting, alpha 4 polypeptide) is a protein-coding gene. Diseases associated with ATP1A4 include diabetic neuropathy, and pharyngitis. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1A2.

UniProtKB/Swiss-Prot: AT1A4_HUMAN, Q13733
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with
the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical
gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a
role in sperm motility

summary for ATP1A4 Gene:
Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients
across the plasma membrane.

Gene Wiki entry for ATP1A4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP1A4 gene promoter:
         AhR   HTF   Nkx5-1   Arnt   Evi-1   AREB6   Pax-3   HNF-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP1A4 promoter sequence
   Search Chromatin IP Primers for ATP1A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP1A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

ATP1A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP1A4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P160121:  view genomic region     (about GC identifiers)

Start:
160,121,352 bp from pter      End:
160,156,767 bp from pter
Size:
35,416 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AT1A4_HUMAN, Q13733 (See protein sequence)
Recommended Name: Sodium/potassium-transporting ATPase subunit alpha-4  
Size: 1029 amino acids; 114166 Da
Subunit: Composed of three subunits: alpha (catalytic), beta and gamma
Sequence caution: Sequence=AAQ07964.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC05228.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q504T2 Q7Z4I9 Q8TBN8 Q8WXA7 Q8WXH7 Q8WY13
Alternative splicing: 2 isoforms:  Q13733-1   Q13733-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP1A4: NX_Q13733

Explore proteomics data for ATP1A4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys170, Lys367, Lys385, Lys618, Lys631, Lys704
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATP1A4 (Q13733) (see all 54)
     QLFGGFS  AVETLGS  DDNFASI  VGIISEG 


    See ATP1A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001734.1  NP_653300.2  

    ENSEMBL proteins: 
     ENSP00000357060   ENSP00000434272   ENSP00000433094  
    Reactome Protein details: Q13733

    ATP1A4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ATP1A4
    GenScript Custom Purified and Recombinant Proteins Services for ATP1A4
    Novus Biologicals ATP1A4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ATP1A4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ATP1A4
    Abcam antibodies for ATP1A4 (Q13733, P05023)
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for ATP1A4
    Search LSBio for Antibodies for ATP1A4

    ATP1A4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATP1A4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATP1A4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PATP: ATPases / P-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: alpha4
    Na+/K+-ATPase

    Selected InterPro protein domains (see all 9):
     IPR023298 ATPase_P-typ_TM_dom
     IPR005775 ATPase_P-typ_Na/K_IIC
     IPR008250 ATPase_P-typ_transduc_dom_A
     IPR023214 HAD-like_dom
     IPR004014 ATPase_P-typ_cation-transptr_N

    Graphical View of Domain Structure for InterPro Entry Q13733

    ProtoNet protein and cluster: Q13733

    4 Blocks protein domains:
    IPB001757 ATPase
    IPB006068 Cation transporting ATPase
    IPB006069 Sodium/potassium-transporting ATPase signature
    IPB008250 E1-E2 ATPase-associated region


    UniProtKB/Swiss-Prot: AT1A4_HUMAN, Q13733
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily


    ATP1A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT1A4_HUMAN, Q13733
    Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with
    the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical
    gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a
    role in sperm motility
    Catalytic activity: ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In)
    Enzyme regulation: Specifically inhibited by an endogenous cardiac glycoside, ouabain

         Enzyme Numbers (IUBMB): EC 3.6.3.91 2 EC 3.6.32

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005391sodium:potassium-exchanging ATPase activity TAS7809153
    GO:0005524ATP binding IEA--
    GO:0015077monovalent inorganic cation transmembrane transporter activity ----
    GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances ----
         
    ATP1A4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Atp1a4):
     reproductive system 

    ATP1A4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Atp1a4tm1Itl for ATP1A4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATP1A4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATP1A4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATP1A4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATP1A4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATP1A4:
    hsa-mir-484 (MIRT041714), hsa-mir-23b-3p (MIRT046260), hsa-mir-26a-5p (MIRT050108), hsa-mir-99a-5p (MIRT048687), hsa-mir-93-3p (MIRT038912), hsa-mir-26b-5p (MIRT028862), hsa-mir-340-5p (MIRT019537), hsa-mir-320a (MIRT044531), hsa-mir-193b-3p (MIRT016292), hsa-mir-30d-5p (MIRT047825), hsa-let-7b-5p (MIRT052345), hsa-mir-92a-3p (MIRT049192), hsa-mir-18a-5p (MIRT050658), hsa-mir-197-3p (MIRT048123), hsa-mir-196a-5p (MIRT048222)

    Block miRNA regulation of human, mouse, rat ATP1A4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ATP1A4:
    hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidATP1A4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATP1A4
    Predesigned siRNA for gene silencing in human, mouse, rat ATP1A4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATP1A4

    Clone
    Products:
         
    OriGene clones in human, mouse for ATP1A4 (see all 14)
    OriGene ORF clones in mouse, rat for ATP1A4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATP1A4 (NM_144699)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP1A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP1A4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATP1A4
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATP1A4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP1A4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AT1A4_HUMAN, Q13733: Cell membrane; Multi-pass membrane protein. Note=In mature sperm, located in the principle
    piece of the sperm flagellum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS7809153
    GO:0005890sodium:potassium-exchanging ATPase complex TAS7809153
    GO:0016021integral component of membrane ----

    ATP1A4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ATP1A4 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Insulin secretion
    Insulin secretion0.36
    Thyroid hormone synthesis0.36
    2Salivary secretion
    Salivary secretion0.34
    Gastric acid secretion0.34
    3Ion channel transport
    Ion channel transport0.58
    4Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Aldosterone Signaling in Epithelial Cells0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATP1A4
        Hepatic ABC Transporters
    Aldosterone Signaling in Epithelial Cells

    1 BioSystems Pathway for ATP1A4
        Calcium Regulation in the Cardiac Cell

    1 Reactome Pathway for ATP1A4
        Ion transport by P-type ATPases


    Selected Kegg Pathways  (Kegg details for ATP1A4) (see all 15):
        Cardiac muscle contraction
    Adrenergic signaling in cardiomyocytes
    Insulin secretion
    Thyroid hormone synthesis
    Thyroid hormone signaling pathway


    ATP1A4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATP1A4
    Interactions:

        GeneGlobe Interaction Network for ATP1A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for ATP1A4 (Q137333 ENSP000003570604) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    YWHABP319463I2D: score=1 
    ATP1A1ENSP000002955984STRING: ENSP00000295598
    ATP1A2ENSP000003544904STRING: ENSP00000354490
    ATP1A3ENSP000003023974STRING: ENSP00000302397
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006754ATP biosynthetic process IEA--
    GO:0006812cation transport ----
    GO:0006813potassium ion transport TAS7809153
    GO:0006814sodium ion transport TAS7809153
    GO:0007283spermatogenesis IEA--

    ATP1A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ATP1A4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Lithium carbonateMood stabilizer; inhibits Na+/K+ ATPase pump activity[554-13-2]
    Digoxin Na+, K+-ATPase inhibitor [20830-75-5]

    7 HMDB Compounds for ATP1A4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    PotassiumK+ (see all 16)7440-09-7--
    SodiumSodium (see all 2)7440-23-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ATP1A4 gene (2 alternative transcripts): 
    NM_001001734.1  NM_144699.3  

    Unigene Cluster for ATP1A4:

    ATPase, Na+/K+ transporting, alpha 4 polypeptide
    Hs.662219  [show with all ESTs]
    Unigene Representative Sequence: NM_144699
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368081(uc001fve.4) ENST00000477338(uc001fvf.4) ENST00000469023(uc001fvg.3)
    ENST00000418334 ENST00000466526 ENST00000470705(uc001fvh.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATP1A4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ATP1A4:
    hsa-miR-4330
    SwitchGear 3'UTR luciferase reporter plasmidATP1A4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATP1A4
    Predesigned siRNA for gene silencing in human, mouse, rat ATP1A4
    Clone
    Products:
         
    OriGene clones in human, mouse for ATP1A4 (see all 14)
    OriGene ORF clones in mouse, rat for ATP1A4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATP1A4 (NM_144699)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP1A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP1A4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ATP1A4
    OriGene qSTAR qPCR primer pairs in human, mouse for ATP1A4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ATP1A4
      QuantiTect SYBR Green Assays in human, mouse, rat ATP1A4
      QuantiFast Probe-based Assays in human, mouse, rat ATP1A4

    Additional mRNA sequence: 

    AF459737.1 AF506797.1 AK098076.1 AK308286.1 AL833335.1 BC028297.1 BC036052.1 BC068570.1 
    BC094801.1 BX647234.1 M16796.1 

    5 DOTS entries:

    DT.101984611  DT.100768176  DT.100806889  DT.92058354  DT.101984609 

    Selected AceView cDNA sequences (see all 25):

    CR605608 M16796 AL705562 BC028297 NM_144699 BG260350 NM_001001734 AA383352 
    BC068570 AK098076 AF506797 AK125812 AF459737 AL833335 BX647234 BX402599 
    BC036052 CB991485 BX359636 BI560630 BI462517 BI462650 BG721910 BG722324 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ATP1A4 expression in normal human tissues (normalized intensities)      ATP1A4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGAGGAT
    ATP1A4 Expression
    About this image


    ATP1A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Testis (Reproductive System)
     
     Placenta (Extraembryonic Tissues)
    ATP1A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATP1A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.662219

    UniProtKB/Swiss-Prot: AT1A4_HUMAN, Q13733
    Tissue specificity: Specifically expressed in testis. Found in very low levels in skeletal muscle. Expressed in
    mature sperm (at protein level)

        Custom PCR Arrays for ATP1A4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ATP1A4
    OriGene qSTAR qPCR primer pairs in human, mouse for ATP1A4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ATP1A4
    QuantiTect SYBR Green Assays in human, mouse, rat ATP1A4
    QuantiFast Probe-based Assays in human, mouse, rat ATP1A4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP1A4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ATP1A4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp1a41 , 5 ATPase, Na+/K+ transporting, alpha 4 polypeptide1, 5 82.31(n)1
    83.8(a)1
      1 (79.54 cM)5
    272221  NM_013734.11  NP_038762.11 
     1722235135 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    79(a)
    1 → many
    GL344724.1(1098-20783)
    zebrafish
    (Danio rerio)
    Actinopterygii atp1a2a6
    ATPase, Na+/K+ transporting, alpha 2a polypeptide
    77(a)
    1 → many
    2(44264576-44317038) ENSDARG00000010472
    fruit fly
    (Drosophila melanogaster)
    Insecta Atpalpha6
    Na pump alpha subunit
    70(a)
    1 → many
    3R(16774436-16801961)
    worm
    (Caenorhabditis elegans)
    Secernentea eat-66
    Protein EAT-6 (eat-6) mRNA, complete cds
    70(a)
    1 → many
    V(13126407-13129995) WBGene00001137
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ENA26
    ENA56
    (see all 3)
    P-type ATPase sodium pump, involved in Na+ efflux ...
    Protein with similarity to P-type ATPase sodium pu...
    (see all 3)
    27(a)
    27(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(531307-534582) YDR039C
    IV(527422-530697) YDR038C


    ENSEMBL Gene Tree for ATP1A4 (if available)
    TreeFam Gene Tree for ATP1A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ATP1A4 gene
    ATP1A22  ATP12A2  ATP1A12  ATP4A2  ATP1A32  
    7 SIMAP similar genes for ATP1A4 using alignment to 2 protein entries:     AT1A4_HUMAN (see all proteins):
    ATP1A2    ATP1A3    ATP1A1    DKFZp666G172    ATP4A    ATP12A
    ATP2C1

    ATP1A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ATP1A4 (see all 1046)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115406391,2
    F--160119448(+) TACCTC/TCTTTT 1 -- us2k12Minor allele frequency- T:0.02CSA WA 120
    rs1429132201,2
    --160119541(+) AGAATC/GTGAGT 1 -- us2k10--------
    rs564037101,2
    C--160119684(+) TCAAGA/GAGGAT 1 -- us2k10--------
    rs1474391081,2
    --160119776(+) ATCAGG/TCCAGG 1 -- us2k10--------
    rs112653331,2
    C,F,A,H--160119778(+) CAGGCC/TAGGCT 1 -- us2k110Minor allele frequency- T:0.24NS EA NA WA 750
    rs1151748631,2
    F--160119884(+) CACCCC/TGTCTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs112653341,2
    C,A,H--160119908(+) TAAAAA/TAAATT 1 -- us2k17Minor allele frequency- T:0.19NA CSA WA EA 367
    rs115785221,2
    C,F,A,H--160120015(+) ATAATC/TGCACC 1 -- us2k113Minor allele frequency- T:0.26NS EA NA WA CSA 785
    rs1155587181,2
    C,F--160120094(+) CAGAAT/CGGGAA 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1396493801,2
    --160120208(+) AAAACA/GTATAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATP1A4 (160121352 - 160156767 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ATP1A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522918CNV Loss19592680
    nsv520399CNV Loss19592680
    nsv872490CNV Loss21882294
    nsv819332CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP1A4
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP1A4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607321    OMIM disorders: --

    7 diseases for ATP1A4:    About MalaCards
    diabetic neuropathy    pharyngitis    neuropathy    hypertension
    pancreatitis    hepatitis    thyroiditis


    ATP1A4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATP1A4

    Export disorders for ATP1A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ATP1A4 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with ATP1A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm. (PubMed id 16175638)1, 2 Hlivko J.T.... James P.F. (Mol. Reprod. Dev. 2006)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4. (PubMed id 12119109)1, 2 Keryanov S. and Gardner K.L. (Gene 2002)
    6. A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. (PubMed id 7809153)1, 2 Shamraj O.I. and Lingrel J.B. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    7. A detailed multipoint gene map of chromosome 1q. (PubMed id 1981991)1, 3 Buetow K.H....Murray J.C. (Genomics 1990)
    8. Multiple genes encode the human Na+,K+-ATPase catalytic subunit. (PubMed id 3035563)1, 3 Shull M.M. and Lingrel J.B. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    9. The transcription factor CREMtau and cAMP regulate promoter activity of the Na,K-ATPase alpha4 isoform. (PubMed id 16894555)1, 9 Rodova M....Blanco G. (Mol. Reprod. Dev. 2006)
    10. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 480 HGNC: 14073 AceView: ATP1A4 Ensembl:ENSG00000132681 euGenes: HUgn480
    ECgene: ATP1A4 Kegg: 480 H-InvDB: ATP1A4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ATP1A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ATP1A4 gene:
    Search GeneIP for patents involving ATP1A4

    Licensable Technologies for ATP1A4 gene:
    Weizmann Institute:"Na, K-ATPase Isoforms and Selective Inhibitors Thereof"
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ATP1A4  
     OriGene qPCR primer pairs and template standards for ATP1A4   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ATP1A4  
     OriGene qSTAR qPCR primer pairs in human, mouse for ATP1A4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ATP1A4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATP1A4   OriGene Custom Protein Services for ATP1A4  

     
     
     Block miRNA regulation of human, mouse, rat ATP1A4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ATP1A4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP1A4 Predesigned siRNA for gene silencing in human, mouse, rat ATP1A4
     QuantiFast Probe-based Assays in human, mouse, rat ATP1A4 QuantiTect SYBR Green Assays in human, mouse, rat ATP1A4
     Custom PCR Arrays for ATP1A4 Search Chromatin IP Primers for ATP1A4
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ATP1A4  GeneGlobe Interaction Network for ATP1A4
     Regulatory tfbs in ATP1A4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ATP1A4 GenScript cDNA clones with any tag delivered in your preferred vector for ATP1A4
     GenScript Custom Assay Services for ATP1A4 GenScript Custom overexpressing Cell Line Services for ATP1A4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for ATP1A4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ATP1A4 proteins
     Antibodies for ATP1A4
     See all of Abcam's Antibodies, Kits and Proteins for ATP1A4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ATP1A4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP1A4
     SwitchGear 3'UTR luciferase reporter plasmids for ATP1A4
     SwitchGear Promoter luciferase reporter plasmids for ATP1A4
     Search ThermoFisher Antibodies for ATP1A4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP1A4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATP1A4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATP1A4
     Search LSBio for Antibodies for ATP1A4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ATP1A4 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4