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Aliases for ATP1A2 Gene

Aliases for ATP1A2 Gene

  • ATPase, Na+/K+ Transporting, Alpha 2 Polypeptide 2 3
  • Sodium Pump Subunit Alpha-2 2 3 4
  • Sodium/Potassium-Transporting ATPase Subunit Alpha-2 2 3
  • Sodium-Potassium ATPase Catalytic Subunit Alpha-2 2 3
  • Na(+)/K(+) ATPase Alpha-2 Subunit 3 4
  • EC 4 63
  • FHM2 3 6
  • MHP2 3 6
  • ATPase, Na+/K+ Transporting, Alpha 2 (+) Polypeptide 2
  • Sodium/Potassium-Transporting ATPase Alpha-2 Chain 3
  • Na+/K+ ATPase, Alpha-A(+) Catalytic Polypeptide 3
  • Na+/K+ ATPase, Alpha-B Polypeptide 3
  • Migraine, Hemiplegic 2 2
  • KIAA0778 4
  • EC 3.6.3 63

External Ids for ATP1A2 Gene

Previous Symbols for ATP1A2 Gene

  • MHP2

Summaries for ATP1A2 Gene

Entrez Gene Summary for ATP1A2 Gene

  • The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]

GeneCards Summary for ATP1A2 Gene

ATP1A2 (ATPase, Na+/K+ Transporting, Alpha 2 Polypeptide) is a Protein Coding gene. Diseases associated with ATP1A2 include migraine, familial hemiplegic, 2 and alternating hemiplegia of childhood. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Ion channel transport. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity. An important paralog of this gene is ATP4A.

UniProtKB/Swiss-Prot for ATP1A2 Gene

  • This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients

Tocris Summary for ATP1A2 Gene

  • Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients across the plasma membrane.

Gene Wiki entry for ATP1A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP1A2 Gene

Genomics for ATP1A2 Gene

Genomic Location for ATP1A2 Gene

160,115,730 bp from pter
160,143,591 bp from pter
27,862 bases
Plus strand

Genomic View for ATP1A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP1A2 Gene

Regulatory Elements for ATP1A2 Gene

Proteins for ATP1A2 Gene

  • Protein details for ATP1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-2
    Protein Accession:
    Secondary Accessions:
    • D3DVE4
    • Q07059
    • Q5JW74
    • Q86UZ5
    • Q9UQ25

    Protein attributes for ATP1A2 Gene

    1020 amino acids
    Molecular mass:
    112265 Da
    Quaternary structure:
    • Composed of three subunits: alpha (catalytic), beta and gamma
    • Sequence=BAA34498.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ATP1A2 Gene

Proteomics data for ATP1A2 Gene at MOPED

Post-translational modifications for ATP1A2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys357, Lys375, Lys602, Lys609, Lys622, Lys626, Lys695, and Lys840

Other Protein References for ATP1A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ATP1A2 Gene

Gene Families for ATP1A2 Gene

  • PATP :ATPases / P-type

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.:
    • P50993
genes like me logo Genes that share domains with ATP1A2: view

Function for ATP1A2 Gene

Molecular function for ATP1A2 Gene

GENATLAS Biochemistry: ATPase,Na+K+,alpha 2 polypeptide
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In)
UniProtKB/Swiss-Prot Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients

Enzyme Numbers (IUBMB) for ATP1A2 Gene

Gene Ontology (GO) - Molecular Function for ATP1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005391 sodium:potassium-exchanging ATPase activity IMP 12539047
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0015077 monovalent inorganic cation transmembrane transporter activity --
genes like me logo Genes that share ontologies with ATP1A2: view
genes like me logo Genes that share phenotypes with ATP1A2: view

Animal Models for ATP1A2 Gene

MGI Knock Outs for ATP1A2:

miRNA for ATP1A2 Gene

miRTarBase miRNAs that target ATP1A2

No data available for Transcription Factor Targeting and HOMER Transcription for ATP1A2 Gene

Localization for ATP1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP1A2 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ATP1A2 Gene COMPARTMENTS Subcellular localization image for ATP1A2 gene
Compartment Confidence
plasma membrane 5
endosome 2

Gene Ontology (GO) - Cellular Components for ATP1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12539047
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005890 sodium:potassium-exchanging ATPase complex IDA 10636900
GO:0005901 caveola IEA --
genes like me logo Genes that share ontologies with ATP1A2: view

Pathways for ATP1A2 Gene

genes like me logo Genes that share pathways with ATP1A2: view

Gene Ontology (GO) - Biological Process for ATP1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001504 neurotransmitter uptake IEA --
GO:0002026 regulation of the force of heart contraction IEA --
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
GO:0006754 ATP biosynthetic process --
GO:0006813 potassium ion transport NAS 10642400
genes like me logo Genes that share ontologies with ATP1A2: view

Compounds for ATP1A2 Gene

(2) Tocris Compounds for ATP1A2 Gene

Compound Action Cas Number
Digoxin Na+, K+-ATPase inhibitor [20830-75-5]
Lithium carbonate Mood stabilizer; inhibits Na+/K+ ATPase pump activity [554-13-2]

(7) HMDB Compounds for ATP1A2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium
  • NFB Orthophosphate
  • K+

(8) Novoseek inferred chemical compound relationships for ATP1A2 Gene

Compound -log(P) Hits PubMed IDs
ouabain 51.5 2
sodium 47.2 10
potassium 29.7 4
calcium 28.5 9
magnesium 3.97 2
genes like me logo Genes that share compounds with ATP1A2: view

Transcripts for ATP1A2 Gene

Unigene Clusters for ATP1A2 Gene

ATPase, Na+/K+ transporting, alpha 2 polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP1A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - - -
SP9: -

ExUns: 15b ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c
SP1: - - -
SP2: -
SP3: - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - -

Relevant External Links for ATP1A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP1A2 Gene

mRNA expression in normal human tissues for ATP1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP1A2 Gene

This gene is overexpressed in Muscle - Skeletal (8.0), Brain - Caudate (basal ganglia) (4.8), Brain - Nucleus accumbens (basal ganglia) (4.3), and Brain - Putamen (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP1A2 Gene

SOURCE GeneReport for Unigene cluster for ATP1A2 Gene Hs.34114

genes like me logo Genes that share expressions with ATP1A2: view

No data available for mRNA Expression by UniProt/SwissProt for ATP1A2 Gene

Orthologs for ATP1A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP1A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP1A2 35
  • 99.4 (n)
  • 99.7 (a)
(Bos Taurus)
Mammalia ATP1A2 35
  • 92.22 (n)
  • 99.02 (a)
ATP1A2 36
  • 99 (a)
(Canis familiaris)
Mammalia ATP1A2 35
  • 91.05 (n)
  • 99.41 (a)
ATP1A2 36
  • 99 (a)
(Mus musculus)
Mammalia Atp1a2 35
  • 90.36 (n)
  • 99.12 (a)
Atp1a2 16
Atp1a2 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
-- 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Atp1a2 35
  • 90.75 (n)
  • 99.12 (a)
(Gallus gallus)
Aves ATP1A2 35
  • 83.48 (n)
  • 93.99 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68460 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atp1a2 35
  • 78.86 (n)
  • 92.94 (a)
(Danio rerio)
Actinopterygii atp1a2a 35
  • 76.3 (n)
  • 86.04 (a)
atp1a2a 36
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atpalpha 36
  • 74 (a)
Atpalpha 37
  • 76 (a)
CG17923 37
  • 63 (a)
CG3701 37
  • 30 (a)
(Caenorhabditis elegans)
Secernentea eat-6 36
  • 72 (a)
Y105E8A.12 37
  • 32 (a)
C02E7.1 37
  • 35 (a)
eat-6 37
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENA1 36
  • 27 (a)
ENA2 36
  • 27 (a)
ENA5 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
Species with no ortholog for ATP1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP1A2 Gene

Gene Tree for ATP1A2 (if available)
Gene Tree for ATP1A2 (if available)

Paralogs for ATP1A2 Gene

Paralogs for ATP1A2 Gene

Selected SIMAP similar genes for ATP1A2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATP1A2: view

Variants for ATP1A2 Gene

Sequence variations from dbSNP and Humsavar for ATP1A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9905 -- 160,143,450(+) TGCAT(A/G)GGCTA utr-variant-3-prime
rs1016732 -- 160,117,178(+) GAAGA(A/G)GTCAT intron-variant
rs1023420 -- 160,124,553(+) GCCTA(C/T)GCCCC intron-variant
rs1023421 -- 160,124,854(+) GTGCA(A/G)GGCAG intron-variant
rs1046995 -- 160,142,951(+) TTCTT(C/T)CCCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATP1A2 Gene

Variant ID Type Subtype PubMed ID
nsv520189 CNV Loss 19592680
nsv872490 CNV Loss 21882294

Relevant External Links for ATP1A2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP1A2 Gene

Disorders for ATP1A2 Gene

(2) OMIM Diseases for ATP1A2 Gene (182340)


  • Migraine, familial hemiplegic, 2 (FHM2) [MIM:602481]: A subtype of migraine with aura associated with hemiparesis in some families. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. {ECO:0000269 PubMed:12539047, ECO:0000269 PubMed:12953268, ECO:0000269 PubMed:21352219, ECO:0000269 PubMed:23838748, ECO:0000269 PubMed:23918834}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Alternating hemiplegia of childhood 1 (AHC1) [MIM:104290]: A rare syndrome of episodic hemi- or quadriplegia lasting minutes to days. Most cases are accompanied by dystonic posturing, choreoathetoid movements, nystagmus, other ocular motor abnormalities, autonomic disturbances, and progressive cognitive impairment. It is typically distinguished from familial hemiplegic migraine by infantile onset and high prevalence of associated neurological deficits that become increasingly obvious with age. {ECO:0000269 PubMed:15174025}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for ATP1A2 Gene

(10) Novoseek inferred disease relationships for ATP1A2 Gene

Disease -log(P) Hits PubMed IDs
hemiplegic migraine familial 97.4 26
migraine hemiplegic 94.1 15
migraine 81.6 11
common migraine 77.6 1
basilar migraine 71.9 1

Relevant External Links for ATP1A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ATP1A2: view

Publications for ATP1A2 Gene

  1. Mapping of a second locus for familial hemiplegic migraine to 1q21-q23 and evidence of further heterogeneity. (PMID: 9403481) Ducros A. … Tournier-Lasserve E. (Ann. Neurol. 1997) 2 3 23
  2. Relation of alleles of the sodium-potassium adenosine triphosphatase alpha 2 gene with blood pressure and lead exposure. (PMID: 11257061) Glenn B.S. … Bressler J. (Am. J. Epidemiol. 2001) 3 23 48
  3. Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. (PMID: 12539047) De Fusco M. … Casari G. (Nat. Genet. 2003) 3 4 23
  4. Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes. (PMID: 16430714) Kung A.W. … Chan V. (Clin. Endocrinol. (Oxf) 2006) 3 23 48
  5. Association analysis of chromosome 1 migraine candidate genes. (PMID: 17727731) Fernandez F. … Griffiths L.R. (BMC Med. Genet. 2007) 3 23 48

Products for ATP1A2 Gene

  • antibodies-online peptides for ATP1A2
  • antibodies-online antibodies for ATP1A2
  • antibodies-online kits for ATP1A2

Sources for ATP1A2 Gene

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