Aliases for ATP1A1 Gene
External Ids for ATP1A1 Gene
Previous GeneCards Identifiers for ATP1A1 Gene
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for ATP1A1 Gene
ATP1A1 (ATPase, Na+/K+ Transporting, Alpha 1 Polypeptide) is a Protein Coding gene. Diseases associated with ATP1A1 include thyrotoxic periodic paralysis. Among its related pathways are Cytoskeletal Signaling and Diuretics Pathway, Pharmacodynamics. GO annotations related to this gene include protein kinase binding and chaperone binding. An important paralog of this gene is ATP4A.
UniProtKB/Swiss-Prot for ATP1A1 Gene
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients
Na+,K+-ATPase is an ion pump responsible for maintaining sodium and potassium electrochemical gradients across the plasma membrane.