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Aliases for ATP13A5 Gene

Aliases for ATP13A5 Gene

  • ATPase 13A5 2 3
  • ATPase Type 13A5 2 3 5
  • P5-ATPase Isoform 5 4
  • EC 63
  • EC 3.6.3.n1 63
  • EC 63
  • EC 3.6.3.- 4
  • P5-ATPase 3
  • EC 3.6.3 63

External Ids for ATP13A5 Gene

Previous GeneCards Identifiers for ATP13A5 Gene

  • GC03U900579
  • GC03M194476
  • GC03M192992
  • GC03M190379

Summaries for ATP13A5 Gene

GeneCards Summary for ATP13A5 Gene

ATP13A5 (ATPase 13A5) is a Protein Coding gene. Among its related pathways are Ion channel transport and Cardiac conduction. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP13A2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP13A5 Gene

Genomics for ATP13A5 Gene

Regulatory Elements for ATP13A5 Gene

Enhancers for ATP13A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP13A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP13A5 Gene

193,274,789 bp from pter
193,378,843 bp from pter
104,055 bases
Minus strand

Genomic View for ATP13A5 Gene

Genes around ATP13A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP13A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP13A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP13A5 Gene

Proteins for ATP13A5 Gene

  • Protein details for ATP13A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable cation-transporting ATPase 13A5
    Protein Accession:
    Secondary Accessions:
    • Q6UWS4
    • Q6ZWL0

    Protein attributes for ATP13A5 Gene

    1218 amino acids
    Molecular mass:
    137327 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89030.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ89030.1; Type=Frameshift; Positions=1126, 1135; Evidence={ECO:0000305}; Sequence=BAC85490.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for ATP13A5 Gene

Proteomics data for ATP13A5 Gene at MOPED

Post-translational modifications for ATP13A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP13A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ATP13A5 Gene

Gene Families for ATP13A5 Gene

Suggested Antigen Peptide Sequences for ATP13A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
genes like me logo Genes that share domains with ATP13A5: view

Function for ATP13A5 Gene

Molecular function for ATP13A5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for ATP13A5 Gene

Gene Ontology (GO) - Molecular Function for ATP13A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019829 cation-transporting ATPase activity IBA,TAS --
genes like me logo Genes that share ontologies with ATP13A5: view
genes like me logo Genes that share phenotypes with ATP13A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP13A5

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATP13A5 Gene

Localization for ATP13A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP13A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ATP13A5 Gene COMPARTMENTS Subcellular localization image for ATP13A5 gene
Compartment Confidence
plasma membrane 5
endosome 1
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ATP13A5 Gene

Pathways & Interactions for ATP13A5 Gene

genes like me logo Genes that share pathways with ATP13A5: view

Pathways by source for ATP13A5 Gene

Interacting Proteins for ATP13A5 Gene

Gene Ontology (GO) - Biological Process for ATP13A5 Gene


No data available for SIGNOR curated interactions for ATP13A5 Gene

Drugs & Compounds for ATP13A5 Gene

(1) Drugs for ATP13A5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for ATP13A5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with ATP13A5: view

Transcripts for ATP13A5 Gene

mRNA/cDNA for ATP13A5 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP13A5 Gene

ATPase type 13A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP13A5 Gene

No ASD Table

Relevant External Links for ATP13A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP13A5 Gene

mRNA expression in normal human tissues for ATP13A5 Gene

mRNA differential expression in normal tissues according to GTEx for ATP13A5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.2), Skin - Not Sun Exposed (Suprapubic) (x4.2), and Minor Salivary Gland (x4.0).

Protein differential expression in normal tissues from HIPED for ATP13A5 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP13A5 Gene

SOURCE GeneReport for Unigene cluster for ATP13A5 Gene Hs.658032

genes like me logo Genes that share expression patterns with ATP13A5: view

Protein tissue co-expression partners for ATP13A5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATP13A5 Gene

Orthologs for ATP13A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP13A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATP13A5 35
  • 87.42 (n)
  • 84.7 (a)
ATP13A5 36
  • 85 (a)
(Canis familiaris)
Mammalia ATP13A5 35
  • 88.19 (n)
  • 86.02 (a)
-- 36
  • 79 (a)
(Mus musculus)
Mammalia Atp13a5 35
  • 83.81 (n)
  • 83.21 (a)
Atp13a5 16
Atp13a5 36
  • 83 (a)
(Pan troglodytes)
Mammalia ATP13A5 35
  • 98.28 (n)
  • 97.62 (a)
ATP13A5 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Atp13a5 35
  • 84.61 (n)
  • 83.79 (a)
(Monodelphis domestica)
Mammalia ATP13A5 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ATP13A5 36
  • 73 (a)
(Gallus gallus)
Aves ATP13A5 35
  • 66.86 (n)
  • 63.98 (a)
ATP13A5 36
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
-- 36
  • 64 (a)
-- 36
  • 60 (a)
-- 36
  • 63 (a)
-- 36
  • 63 (a)
-- 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp13a5 35
  • 60.49 (n)
  • 56.4 (a)
(Danio rerio)
Actinopterygii CABZ01111936.1 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32000 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea catp-5 36
  • 31 (a)
catp-6 36
  • 32 (a)
catp-7 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK9 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for ATP13A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP13A5 Gene

Gene Tree for ATP13A5 (if available)
Gene Tree for ATP13A5 (if available)

Paralogs for ATP13A5 Gene

Paralogs for ATP13A5 Gene

(3) SIMAP similar genes for ATP13A5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP13A5: view

Variants for ATP13A5 Gene

Sequence variations from dbSNP and Humsavar for ATP13A5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6797429 - 193,362,625(+) CACTT(A/C/G)CATGC reference, missense
VAR_043615 -
VAR_043616 -
VAR_043617 -
VAR_043618 -

Structural Variations from Database of Genomic Variants (DGV) for ATP13A5 Gene

Variant ID Type Subtype PubMed ID
nsv878123 CNV Gain 21882294
esv2658671 CNV Deletion 23128226
esv1179184 CNV Insertion 17803354

Variation tolerance for ATP13A5 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.04; 99.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP13A5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP13A5 Gene

Disorders for ATP13A5 Gene

Relevant External Links for ATP13A5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATP13A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP13A5 Gene

Publications for ATP13A5 Gene

  1. Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay. (PMID: 15925480) Kwasnicka-Crawford D.A. … Scherer S.W. (Genomics 2005) 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for ATP13A5 Gene

Sources for ATP13A5 Gene