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Aliases for ATP13A5 Gene

Aliases for ATP13A5 Gene

  • ATPase Type 13A5 2 3
  • Probable Cation-Transporting ATPase 13A5 3
  • P5-ATPase Isoform 5 4
  • EC 3.6.3.12 64
  • EC 3.6.3.n1 64
  • EC 3.6.3.8 64
  • EC 3.6.3.- 4
  • P5-ATPase 3
  • EC 3.6.3 64

External Ids for ATP13A5 Gene

Summaries for ATP13A5 Gene

GeneCards Summary for ATP13A5 Gene

ATP13A5 (ATPase Type 13A5) is a Protein Coding gene. GO annotations related to this gene include cation-transporting ATPase activity. An important paralog of this gene is ATP13A2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP13A5 Gene

Genomics for ATP13A5 Gene

Genomic Location for ATP13A5 Gene

Start:
193,274,790 bp from pter
End:
193,378,843 bp from pter
Size:
104,054 bases
Orientation:
Minus strand

Genomic View for ATP13A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP13A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP13A5 Gene

Regulatory Elements for ATP13A5 Gene

Proteins for ATP13A5 Gene

  • Protein details for ATP13A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VNC0-AT135_HUMAN
    Recommended name:
    Probable cation-transporting ATPase 13A5
    Protein Accession:
    Q4VNC0
    Secondary Accessions:
    • Q6UWS4
    • Q6ZWL0

    Protein attributes for ATP13A5 Gene

    Size:
    1218 amino acids
    Molecular mass:
    137327 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89030.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ89030.1; Type=Frameshift; Positions=1126, 1135; Evidence={ECO:0000305}; Sequence=BAC85490.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for ATP13A5 Gene

Proteomics data for ATP13A5 Gene at MOPED

Post-translational modifications for ATP13A5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn540, Asn669, and Asn819

Other Protein References for ATP13A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ATP13A5 Gene

Gene Families for ATP13A5 Gene

HGNC:
  • PATP :ATPases / P-type

UniProtKB/Swiss-Prot:

AT135_HUMAN
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.:
    • Q4VNC0
genes like me logo Genes that share domains with ATP13A5: view

Function for ATP13A5 Gene

Molecular function for ATP13A5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for ATP13A5 Gene

Gene Ontology (GO) - Molecular Function for ATP13A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
GO:0019829 cation-transporting ATPase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ATP13A5: view

Phenotypes for ATP13A5 Gene

genes like me logo Genes that share phenotypes with ATP13A5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATP13A5 Gene

Localization for ATP13A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP13A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP13A5 Gene COMPARTMENTS Subcellular localization image for ATP13A5 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP13A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP13A5: view

Pathways for ATP13A5 Gene

SuperPathways for ATP13A5 Gene

No Data Available

Interacting Proteins for ATP13A5 Gene

Gene Ontology (GO) - Biological Process for ATP13A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006812 cation transport IEA --
GO:0008152 metabolic process IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with ATP13A5: view

No data available for Pathways by source for ATP13A5 Gene

Transcripts for ATP13A5 Gene

mRNA/cDNA for ATP13A5 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP13A5 Gene

ATPase type 13A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP13A5 Gene

No ASD Table

Relevant External Links for ATP13A5 Gene

GeneLoc Exon Structure for
ATP13A5
ECgene alternative splicing isoforms for
ATP13A5

Expression for ATP13A5 Gene

mRNA expression in normal human tissues for ATP13A5 Gene

mRNA differential expression in normal tissues according to GTEx for ATP13A5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (7.2), Skin - Not Sun Exposed (Suprapubic) (4.2), and Minor Salivary Gland (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP13A5 Gene

SOURCE GeneReport for Unigene cluster for ATP13A5 Gene Hs.658032

genes like me logo Genes that share expressions with ATP13A5: view

Orthologs for ATP13A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP13A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP13A5 36
  • 98.28 (n)
  • 97.62 (a)
ATP13A5 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP13A5 36
  • 87.42 (n)
  • 84.7 (a)
ATP13A5 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 79 (a)
ManyToMany
ATP13A5 36
  • 88.19 (n)
  • 86.02 (a)
mouse
(Mus musculus)
Mammalia Atp13a5 36
  • 83.81 (n)
  • 83.21 (a)
Atp13a5 16
Atp13a5 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP13A5 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP13A5 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp13a5 36
  • 84.61 (n)
  • 83.79 (a)
chicken
(Gallus gallus)
Aves ATP13A5 36
  • 66.86 (n)
  • 63.98 (a)
ATP13A5 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
OneToMany
-- 37
  • 64 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
-- 37
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia atp13a5 36
  • 60.49 (n)
  • 56.4 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01111936.1 37
  • 41 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32000 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea catp-5 37
  • 31 (a)
ManyToMany
catp-6 37
  • 32 (a)
ManyToMany
catp-7 37
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK9 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToMany
Species with no ortholog for ATP13A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP13A5 Gene

ENSEMBL:
Gene Tree for ATP13A5 (if available)
TreeFam:
Gene Tree for ATP13A5 (if available)

Paralogs for ATP13A5 Gene

Paralogs for ATP13A5 Gene

Selected SIMAP similar genes for ATP13A5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP13A5: view

Variants for ATP13A5 Gene

Sequence variations from dbSNP and Humsavar for ATP13A5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs735930 -- 193,323,209(+) ACTTA(C/T)CTGTT intron-variant
rs750907 -- 193,323,961(-) TTACA(C/T)CCTGT intron-variant
rs902189 -- 193,323,498(+) CCCAA(A/C)CAAGT intron-variant
rs923494 -- 193,364,349(-) GGTTT(A/G)TTGAA intron-variant
rs923495 -- 193,364,075(-) GAAAG(C/T)CATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP13A5 Gene

Variant ID Type Subtype PubMed ID
nsv878123 CNV Gain 21882294
esv2658671 CNV Deletion 23128226
esv1179184 CNV Insertion 17803354

Relevant External Links for ATP13A5 Gene

HapMap Linkage Disequilibrium report
ATP13A5
Human Gene Mutation Database (HGMD)
ATP13A5

Disorders for ATP13A5 Gene

Relevant External Links for ATP13A5

Genetic Association Database (GAD)
ATP13A5
genes like me logo Genes that share disorders with ATP13A5: view

No data available for UniProtKB/Swiss-Prot for ATP13A5 Gene

Publications for ATP13A5 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay. (PMID: 15925480) Kwasnicka-Crawford D.A. … Scherer S.W. (Genomics 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for ATP13A5 Gene

Sources for ATP13A5 Gene

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