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Aliases for ATP13A3 Gene

Aliases for ATP13A3 Gene

  • ATPase 13A3 2 3 5
  • ATPase Family Homolog Up-Regulated In Senescence Cells 1 3 4
  • ATPase Type 13A3 2 3
  • AFURS1 3 4
  • ATPase Family Homolog Up Regulated In Senescence Cells 2
  • Probable Cation-Transporting ATPase 13A3 3
  • EC 3.6.3.n1 61
  • EC 3.6.3.12 61
  • EC 3.6.3.- 4
  • EC 3.6.3 61

External Ids for ATP13A3 Gene

Previous GeneCards Identifiers for ATP13A3 Gene

  • GC03M195606
  • GC03M194123
  • GC03M191502

Summaries for ATP13A3 Gene

Entrez Gene Summary for ATP13A3 Gene

  • ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).[supplied by OMIM, Aug 2008]

GeneCards Summary for ATP13A3 Gene

ATP13A3 (ATPase 13A3) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP13A4.

Gene Wiki entry for ATP13A3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP13A3 Gene

Genomics for ATP13A3 Gene

Regulatory Elements for ATP13A3 Gene

Enhancers for ATP13A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G194526 1.8 FANTOM5 Ensembl ENCODE dbSUPER 36.5 -28.9 -28870 2.3 TBP ZNF133 RAD21 YY1 GATA2 ZNF366 FOS ETV6 U2AF2 DEK ATP13A3 ENSG00000244675 LINC00884 GP5 HES1 LOC105374290
GH03G194520 1.7 FANTOM5 Ensembl ENCODE dbSUPER 34.1 -23.5 -23474 3.2 HDGF TBP PKNOX1 ATF1 ARID4B BRCA1 ZNF48 RAD21 YY1 GATA2 ATP13A3 ENSG00000244675 LINC00884 TMEM44-AS1 LOC105374290
GH03G194571 2 FANTOM5 Ensembl ENCODE dbSUPER 27.3 -75.5 -75468 5.3 PKNOX1 MLX CREB3L1 ARNT ARID4B FEZF1 ZNF2 YY1 SLC30A9 ZNF766 ATP13A3 LSG1 TMEM44-AS1 ENSG00000244675 LINC00884 RNU6-1101P GP5 ENSG00000229334 CPN2 ACAP2-IT1
GH03G194561 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.2 -63.4 -63385 1.4 PKNOX1 ATF1 CREB3L1 ARNT SIN3A BRCA1 TCF12 ELK1 GATA2 FOS TMEM44-AS1 ATP13A3 RNU6-1101P ENSG00000244675 LINC00884 GP5 HES1 RPL23AP93
GH03G194577 1.4 Ensembl ENCODE dbSUPER 25.4 -80.4 -80370 2.3 YY1 GLIS2 GATA2 FOS JUNB ZHX2 REST NFIL3 ATF4 SMARCA4 ATP13A3 ENSG00000244675 LINC00884 RNU6-1101P GP5 CPN2 TMEM44-AS1 RPL23AP93
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP13A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP13A3 Gene

Chromosome:
3
Start:
194,402,672 bp from pter
End:
194,498,364 bp from pter
Size:
95,693 bases
Orientation:
Minus strand

Genomic View for ATP13A3 Gene

Genes around ATP13A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP13A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP13A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP13A3 Gene

Proteins for ATP13A3 Gene

  • Protein details for ATP13A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7F0-AT133_HUMAN
    Recommended name:
    Probable cation-transporting ATPase 13A3
    Protein Accession:
    Q9H7F0
    Secondary Accessions:
    • Q8NC11
    • Q96KS1

    Protein attributes for ATP13A3 Gene

    Size:
    1226 amino acids
    Molecular mass:
    138043 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14942.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14942.1; Type=Frameshift; Positions=1065; Evidence={ECO:0000305}; Sequence=BAC11398.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP13A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP13A3 Gene

Selected DME Specific Peptides for ATP13A3 Gene

Q9H7F0:
  • ESMLTGES
  • IRTVMVTGD
  • DKTGTLT
  • YAQRRLKK
  • SNLGDFQFL
  • VFARMAP
  • FPFSSALQRM
  • PCDAVLI
  • QGFRVIALA
  • VPPALPA
  • ARMAPDQK
  • LLRTTDEF
  • VGMCGDGANDCGALK
  • KGQLVRSI
  • DEYYYYA

Post-translational modifications for ATP13A3 Gene

  • Ubiquitination at posLast=128128, posLast=377377, posLast=389389, and posLast=914914
  • Modification sites at PhosphoSitePlus

Domains & Families for ATP13A3 Gene

Gene Families for ATP13A3 Gene

Suggested Antigen Peptide Sequences for ATP13A3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7F0

UniProtKB/Swiss-Prot:

AT133_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
genes like me logo Genes that share domains with ATP13A3: view

Function for ATP13A3 Gene

Molecular function for ATP13A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for ATP13A3 Gene

Gene Ontology (GO) - Molecular Function for ATP13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005388 calcium-transporting ATPase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ATP13A3: view

Phenotypes for ATP13A3 Gene

genes like me logo Genes that share phenotypes with ATP13A3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP13A3

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP13A3 Gene

Localization for ATP13A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP13A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP13A3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ATP13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with ATP13A3: view

Pathways & Interactions for ATP13A3 Gene

SuperPathways for ATP13A3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATP13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport IEA --
GO:0006874 cellular calcium ion homeostasis IBA --
GO:0070588 calcium ion transmembrane transport IEA --
GO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with ATP13A3: view

No data available for Pathways by source and SIGNOR curated interactions for ATP13A3 Gene

Drugs & Compounds for ATP13A3 Gene

(3) Drugs for ATP13A3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for ATP13A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ATP13A3: view

Transcripts for ATP13A3 Gene

Unigene Clusters for ATP13A3 Gene

ATPase type 13A3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP13A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for ATP13A3 Gene

GeneLoc Exon Structure for
ATP13A3
ECgene alternative splicing isoforms for
ATP13A3

Expression for ATP13A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP13A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP13A3 Gene

This gene is overexpressed in Breast (27.0), Placenta (15.2), Amniocyte (13.9), and Pancreas (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP13A3 Gene



Protein tissue co-expression partners for ATP13A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP13A3 Gene:

ATP13A3

SOURCE GeneReport for Unigene cluster for ATP13A3 Gene:

Hs.529609

Evidence on tissue expression from TISSUES for ATP13A3 Gene

  • Liver(4.4)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with ATP13A3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP13A3 Gene

Orthologs for ATP13A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP13A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP13A3 35 34
  • 99.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ATP13A3 35 34
  • 91.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ATP13A3 35 34
  • 90.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Atp13a3 16 35 34
  • 88.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATP13A3 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP13A3 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP13A3 35 34
  • 78.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP13A3 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp13a3 34
  • 73.55 (n)
zebrafish
(Danio rerio)
Actinopterygii ATP13A3 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32000 34 35
  • 51.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011271 34
  • 48.4 (n)
worm
(Caenorhabditis elegans)
Secernentea catp-6 35 34
  • 53.09 (n)
ManyToMany
catp-7 35
  • 37 (a)
ManyToMany
catp-5 35
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK9 34 35 37
  • 50.91 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B08217g 34
  • 50.63 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR567W 34
  • 49.25 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1672.11c 34
  • 50.14 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10143 34
  • 49.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for ATP13A3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP13A3 Gene

ENSEMBL:
Gene Tree for ATP13A3 (if available)
TreeFam:
Gene Tree for ATP13A3 (if available)

Paralogs for ATP13A3 Gene

Paralogs for ATP13A3 Gene

(3) SIMAP similar genes for ATP13A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATP13A3: view

Variants for ATP13A3 Gene

Sequence variations from dbSNP and Humsavar for ATP13A3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000026780 -- 194,439,936(+) CTCTC(C/T)ATAAA intron-variant
rs1000045581 -- 194,424,156(+) TAATA(C/T)AGTTC intron-variant
rs1000094278 -- 194,482,082(+) AAACA(A/T)CCTTC intron-variant
rs1000147145 -- 194,480,682(+) CTAAG(C/T)TATTT intron-variant
rs1000203246 -- 194,415,452(+) CTTAT(C/T)TAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP13A3 Gene

Variant ID Type Subtype PubMed ID
dgv1442e212 CNV loss 25503493
esv3599196 CNV loss 21293372
esv3599198 CNV loss 21293372
nsv516867 CNV gain+loss 19592680

Variation tolerance for ATP13A3 Gene

Residual Variation Intolerance Score: 19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP13A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP13A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP13A3 Gene

Disorders for ATP13A3 Gene

Relevant External Links for ATP13A3

Genetic Association Database (GAD)
ATP13A3
Human Genome Epidemiology (HuGE) Navigator
ATP13A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP13A3

No disorders were found for ATP13A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP13A3 Gene

Publications for ATP13A3 Gene

  1. Cloning the AFURS1 gene which is up-regulated in senescent human parenchymal kidney cells. (PMID: 11867234) Habtemichael N. … Kovacs G. (Gene 2002) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ATP13A3 Gene

Sources for ATP13A3 Gene

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