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Aliases for ATP13A3 Gene

Aliases for ATP13A3 Gene

  • ATPase Type 13A3 2 3
  • AFURS1 3 4 6
  • ATPase Family Homolog Up-Regulated In Senescence Cells 1 3 4
  • ATPase Family Homolog Up Regulated In Senescence Cells 2
  • Probable Cation-Transporting ATPase 13A3 3
  • EC 3.6.3.n1 63
  • EC 3.6.3.12 63
  • EC 3.6.3.- 4
  • EC 3.6.3 63

External Ids for ATP13A3 Gene

Previous GeneCards Identifiers for ATP13A3 Gene

  • GC03M195606
  • GC03M194123
  • GC03M191502

Summaries for ATP13A3 Gene

Entrez Gene Summary for ATP13A3 Gene

  • ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).[supplied by OMIM, Aug 2008]

GeneCards Summary for ATP13A3 Gene

ATP13A3 (ATPase Type 13A3) is a Protein Coding gene. GO annotations related to this gene include cation-transporting ATPase activity. An important paralog of this gene is ATP13A2.

Gene Wiki entry for ATP13A3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP13A3 Gene

Genomics for ATP13A3 Gene

Regulatory Elements for ATP13A3 Gene

Genomic Location for ATP13A3 Gene

Start:
194,402,672 bp from pter
End:
194,498,364 bp from pter
Size:
95,693 bases
Orientation:
Minus strand

Genomic View for ATP13A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP13A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP13A3 Gene

Proteins for ATP13A3 Gene

  • Protein details for ATP13A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7F0-AT133_HUMAN
    Recommended name:
    Probable cation-transporting ATPase 13A3
    Protein Accession:
    Q9H7F0
    Secondary Accessions:
    • Q8NC11
    • Q96KS1

    Protein attributes for ATP13A3 Gene

    Size:
    1226 amino acids
    Molecular mass:
    138043 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14942.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14942.1; Type=Frameshift; Positions=1065; Evidence={ECO:0000305}; Sequence=BAC11398.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP13A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP13A3 Gene

Proteomics data for ATP13A3 Gene at MOPED

Post-translational modifications for ATP13A3 Gene

  • Ubiquitination at Lys128, Lys377, Lys389, and Lys914
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP13A3 Gene

Domains for ATP13A3 Gene

Gene Families for ATP13A3 Gene

HGNC:
  • PATP :ATPases / P-type

Suggested Antigen Peptide Sequences for ATP13A3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7F0

UniProtKB/Swiss-Prot:

AT133_HUMAN :
  • Q9H7F0
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
genes like me logo Genes that share domains with ATP13A3: view

Function for ATP13A3 Gene

Molecular function for ATP13A3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB) for ATP13A3 Gene

Gene Ontology (GO) - Molecular Function for ATP13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
GO:0019829 cation-transporting ATPase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ATP13A3: view

Phenotypes for ATP13A3 Gene

GenomeRNAi human phenotypes for ATP13A3:
genes like me logo Genes that share phenotypes with ATP13A3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP13A3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP13A3 Gene

Localization for ATP13A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP13A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP13A3 Gene COMPARTMENTS Subcellular localization image for ATP13A3 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP13A3: view

Pathways for ATP13A3 Gene

SuperPathways for ATP13A3 Gene

No Data Available

Interacting Proteins for ATP13A3 Gene

Gene Ontology (GO) - Biological Process for ATP13A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006812 cation transport IEA --
GO:0008152 metabolic process IEA --
GO:0098655 cation transmembrane transport --
genes like me logo Genes that share ontologies with ATP13A3: view

No data available for Pathways by source for ATP13A3 Gene

Transcripts for ATP13A3 Gene

Unigene Clusters for ATP13A3 Gene

ATPase type 13A3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP13A3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP13A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for ATP13A3 Gene

GeneLoc Exon Structure for
ATP13A3
ECgene alternative splicing isoforms for
ATP13A3

Expression for ATP13A3 Gene

mRNA expression in normal human tissues for ATP13A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ATP13A3 Gene

This gene is overexpressed in Breast (27.0), Placenta (15.2), Amniocyte (13.9), and Pancreas (12.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP13A3 Gene

SOURCE GeneReport for Unigene cluster for ATP13A3 Gene Hs.529609

genes like me logo Genes that share expressions with ATP13A3: view

Expression partners for ATP13A3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP13A3 Gene

Orthologs for ATP13A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP13A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP13A3 35
  • 90.54 (n)
  • 91.19 (a)
ATP13A3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP13A3 35
  • 91.95 (n)
  • 93.15 (a)
ATP13A3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp13a3 35
  • 88.31 (n)
  • 89.82 (a)
Atp13a3 16
Atp13a3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP13A3 35
  • 99.76 (n)
  • 99.67 (a)
ATP13A3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP13A3 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP13A3 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP13A3 35
  • 78.19 (n)
  • 79.77 (a)
ATP13A3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP13A3 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp13a3 35
  • 73.55 (n)
  • 76.63 (a)
zebrafish
(Danio rerio)
Actinopterygii ATP13A3 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011271 35
  • 48.4 (n)
  • 46.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32000 35
  • 51.48 (n)
  • 43.52 (a)
CG32000 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea catp-6 35
  • 53.09 (n)
  • 44.85 (a)
catp-5 36
  • 35 (a)
ManyToMany
catp-6 36
  • 37 (a)
ManyToMany
catp-7 36
  • 37 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR567W 35
  • 49.25 (n)
  • 40.79 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B08217g 35
  • 50.63 (n)
  • 41.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK9 35
  • 50.91 (n)
  • 41.42 (a)
YPK9 36
  • 29 (a)
OneToMany
YPK9 38
bread mold
(Neurospora crassa)
Ascomycetes NCU10143 35
  • 49.16 (n)
  • 40.66 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1672.11c 35
  • 50.14 (n)
  • 41.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ATP13A3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP13A3 Gene

ENSEMBL:
Gene Tree for ATP13A3 (if available)
TreeFam:
Gene Tree for ATP13A3 (if available)

Paralogs for ATP13A3 Gene

Paralogs for ATP13A3 Gene

Selected SIMAP similar genes for ATP13A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATP13A3: view

Variants for ATP13A3 Gene

Sequence variations from dbSNP and Humsavar for ATP13A3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11900 -- 194,403,692(+) ATGGT(A/G)ACCTA utr-variant-3-prime
rs14414 -- 194,403,895(-) AGTTA(A/G)TAAGG utr-variant-3-prime
rs953486 -- 194,451,496(-) CTGAA(G/T)ATAAT intron-variant
rs953487 -- 194,451,424(-) TACAT(A/G)TCATT intron-variant
rs1032475 -- 194,452,224(+) TGGTG(C/T)GTACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP13A3 Gene

Variant ID Type Subtype PubMed ID
nsv516867 CNV Gain+Loss 19592680
nsv878127 CNV Gain 21882294

Relevant External Links for ATP13A3 Gene

HapMap Linkage Disequilibrium report
ATP13A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP13A3 Gene

Disorders for ATP13A3 Gene

Relevant External Links for ATP13A3

Genetic Association Database (GAD)
ATP13A3
Human Genome Epidemiology (HuGE) Navigator
ATP13A3

No disorders were found for ATP13A3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ATP13A3 Gene

Publications for ATP13A3 Gene

  1. Cloning the AFURS1 gene which is up-regulated in senescent human parenchymal kidney cells. (PMID: 11867234) Habtemichael N. … Kovacs G. (Gene 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for ATP13A3 Gene

Sources for ATP13A3 Gene

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