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ATP13A3 Gene

protein-coding   GIFtS: 55
GCID: GC03M194123

ATPase Type 13A3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase Type 13A31 2     EC 3.6.3.-3
AFURS12 3 5     EC 3.6.38
ATPase Family Homolog Up-Regulated In Senescence Cells 12 3     EC 3.6.3.128
ATPase Family Homolog Up Regulated In Senescence Cells1     EC 3.6.3.n18
Probable Cation-Transporting ATPase 13A32     

External Ids:    HGNC: 241131   Entrez Gene: 795722   Ensembl: ENSG000001336577   OMIM: 6102325   UniProtKB: Q9H7F03   

Export aliases for ATP13A3 gene to outside databases

Previous GC identifers: GC03M195606 GC03M191502


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATP13A3 Gene:
ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes.
Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).(supplied by OMIM, Aug 2008)

GeneCards Summary for ATP13A3 Gene:
ATP13A3 (ATPase type 13A3) is a protein-coding gene. Diseases associated with ATP13A3 include parkinson's disease, and malaria. GO annotations related to this gene include cation-transporting ATPase activity. An important paralog of this gene is ATP13A5.

Gene Wiki entry for ATP13A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP13A3 gene promoter:
         Pax-5   Pbx1a   MyoD   C/EBPalpha   N-Myc   c-Rel   Ik-2   FOXO1a   Sox9   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ATP13A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP13A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

ATP13A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP13A3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M194123:  view genomic region     (about GC identifiers)

Start:
194,123,401 bp from pter      End:
194,219,093 bp from pter
Size:
95,693 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AT133_HUMAN, Q9H7F0 (See protein sequence)
Recommended Name: Probable cation-transporting ATPase 13A3  
Size: 1226 amino acids; 138043 Da
Sequence caution: Sequence=BAB14942.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14942.1; Type=Frameshift; Positions=1065; Sequence=BAC11398.1; Type=Erroneous initiation;
Secondary accessions: Q8NC11 Q96KS1
Alternative splicing: 2 isoforms:  Q9H7F0-1   Q9H7F0-2   (Dubious isoform produced through aberrant splice sites)

Explore the universe of human proteins at neXtProt for ATP13A3: NX_Q9H7F0

Explore proteomics data for ATP13A3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys128, Lys377, Lys389, Lys914
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATP13A3 (Q9H7F0) (see all 15)
     DKTGTLT  VPPALPA  DEYYYYA  VFARMAP 


    See ATP13A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078800.3  
    ENSEMBL proteins: 
     ENSP00000416508   ENSP00000402550   ENSP00000406234   ENSP00000410767   ENSP00000256031  

    ATP13A3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PATP: ATPases / P-type

    Selected InterPro protein domains (see all 7):
     IPR008250 ATPase_P-typ_transduc_dom_A
     IPR023214 HAD-like_dom
     IPR004014 ATPase_P-typ_cation-transptr_N
     IPR006544 ATPase_P-typ_Cation_typ_V
     IPR001757 Cation_transp_P_typ_ATPase

    Graphical View of Domain Structure for InterPro Entry Q9H7F0

    ProtoNet protein and cluster: Q9H7F0

    2 Blocks protein domains:
    IPB001757 ATPase
    IPB008250 E1-E2 ATPase-associated region


    UniProtKB/Swiss-Prot: AT133_HUMAN, Q9H7F0
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily


    ATP13A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT133_HUMAN, Q9H7F0
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.3.n12 EC 3.6.3.122 EC 3.6.32 EC 3.6.3.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity ----
    GO:0019829cation-transporting ATPase activity IEA--
    GO:0046872metal ion binding IEA--
         
    ATP13A3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ATP13A3:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATP13A3
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    miRNA
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    miRTarBase miRNAs that target ATP13A3:
    hsa-mir-150-5p (MIRT045387), hsa-mir-182-5p (MIRT047218), hsa-mir-98-5p (MIRT027500), hsa-mir-590-3p (MIRT016221), hsa-mir-16-5p (MIRT031517), hsa-mir-103a-3p (MIRT027039), hsa-mir-122-5p (MIRT023239)

    Block miRNA regulation of human, mouse, rat ATP13A3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATP13A3 (see all 83):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-607 hsa-miR-300 hsa-miR-376b hsa-miR-15a hsa-miR-1245 hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ATP13A3

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    GenScript: all cDNA clones in your preferred vector: ATP13A3 (NM_024524)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP13A3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP13A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AT133_HUMAN, Q9H7F0: Membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    ATP13A3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATP13A3
    Interactions:

        Search GeneGlobe Interaction Network for ATP13A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATP13A3 (Q9H7F03 ENSP000002560314) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALG1Q9BT223I2D: score=1 
    AMD1P177073I2D: score=1 
    ARFGAP1Q8N6T33I2D: score=1 
    ATG13O751433I2D: score=1 
    CHAC2Q8WUX23I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----

    ATP13A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATP13A3 (AT133)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATP13A3 gene: 
    NM_024524.3  

    Unigene Cluster for ATP13A3:

    ATPase type 13A3
    Hs.529609  [show with all ESTs]
    Unigene Representative Sequence: NM_024524
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000439040(uc003ftx.4) ENST00000429136 ENST00000461660 ENST00000497567
    ENST00000484023 ENST00000485194 ENST00000492983 ENST00000457986 ENST00000446356
    ENST00000256031(uc003fty.4 uc003ftz.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat ATP13A3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATP13A3 (see all 83):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-607 hsa-miR-300 hsa-miR-376b hsa-miR-15a hsa-miR-1245 hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ATP13A3 (NM_024524)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP13A3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ATP13A3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATP13A3
      QuantiTect SYBR Green Assays in human, mouse, rat ATP13A3
      QuantiFast Probe-based Assays in human, mouse, rat ATP13A3

    Additional mRNA sequence: 

    AK024639.1 AK075094.1 AK225064.1 BC037805.1 BC106085.1 BX641098.1 Z24724.1 

    16 DOTS entries:

    DT.91756609  DT.418012  DT.100027435  DT.120891538  DT.206524  DT.121643354  DT.120891595  DT.95150727 
    DT.100027434  DT.70100632  DT.100722542  DT.91756594  DT.97800424  DT.102820967  DT.120891542  DT.91693162 

    Selected AceView cDNA sequences (see all 313):

    BX504367 AA041539 BP365168 AI738461 AW516955 AI358596 AA844477 AI479305 
    BU674792 BQ953527 AA298222 AK024639 AI262048 R34075 BG208988 BE768532 
    BQ225555 AL704543 AI276056 BE501905 BM802412 BQ003765 AI285749 AI656377 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATP13A3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for ATP13A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATP13A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATTTTGAC
    ATP13A3 Expression
    About this image


    ATP13A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Thyroid (Endocrine System)
     
     Liver (Hepatobiliary System)
    ATP13A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATP13A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529609
        Custom PCR Arrays for ATP13A3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP13A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ATP13A3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp13a31 , 5 ATPase type 13A31, 5 88.31(n)1
    89.82(a)1
      16 (21.26 cM)5
    2240881  NM_001128096.11  NP_001121568.11 
     303124235 
    chicken
    (Gallus gallus)
    Aves ATP13A31 ATPase type 13A3 78.19(n)
    79.77(a)
      424898  XM_004943326.1  XP_004943383.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATP13A36
    ATPase type 13A3
    62(a)
    1 ↔ 1
    GL343538.1(417561-468252)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atp13a31 ATPase type 13A3 73.55(n)
    76.63(a)
      100497750  XM_002937844.2  XP_002937890.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ATP13A36
    ATPase type 13A3
    61(a)
    1 ↔ 1
    11(34955004-34984427) ENSDARG00000076622
    fruit fly
    (Drosophila melanogaster)
    Insecta CG320001 CG32000 51.48(n)
    43.52(a)
      317815  NM_001103379.2  NP_001096849.1 
    worm
    (Caenorhabditis elegans)
    Secernentea catp-61 catp-6 53.09(n)
    44.85(a)
      177822  NM_001268501.1  NP_001255430.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YPK9(YOR291W)4
    YPK91
    Vacuolar protein with a possible role in sequestering more4
    YPK91
    50.91(n)1
    41.42(a)1
      15(861175-865593)4
    8544661, 4  NP_014934.11, 4 


    ENSEMBL Gene Tree for ATP13A3 (if available)
    TreeFam Gene Tree for ATP13A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATP13A3 gene
    ATP13A52  ATP13A22  ATP13A42  
    3 SIMAP similar genes for ATP13A3 using alignment to 4 protein entries:     AT133_HUMAN (see all proteins):
    ATP13A4    ATP13A5    ATP13A2

    ATP13A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATP13A3 (see all 1482)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928296131,2
    --194122907(+) AACTTC/GAGCTA 1 -- int10--------
    rs1848272371,2
    --194122921(+) GCAGGC/TAGGCC 1 -- int10--------
    rs1889505061,2
    --194122937(+) CCCCCA/GAATTC 1 -- int10--------
    rs1157756781,2
    C,F--194123002(+) CTGAGC/TTCCAT 1 -- int11Minor allele frequency- T:0.03NA 120
    rs76095871,2
    C,F,A,H--194123286(+) TTTTTT/AAAAAA 1 -- int13Minor allele frequency- A:0.50NA 8
    rs2002634201,2
    --194123286(+) TTTTT-/AAAAAA 1 -- int10--------
    rs98177601,2
    C,F,A,H--194123287(+) TTTTTT/AAAAAA 1 -- int12Minor allele frequency- A:0.50NA 6
    rs762989061,2
    C--194123288(+) TTTTAA/TAAAAA 1 -- int10--------
    rs1923035541,2
    --194123311(+) ATGGGG/TAAGTA 1 -- int10--------
    rs1848901131,2
    --194123552(+) AAATAC/TAAAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ATP13A3 (194123401 - 194219093 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ATP13A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv878127CNV Gain21882294
    nsv516867CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP13A3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610232    OMIM disorders: --

    2 diseases for ATP13A3:    
    About MalaCards
    parkinson's disease    malaria


    ATP13A3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATP13A3
    Human Genome Epidemiology (HuGE) Navigator: ATP13A3 (3 documents)

    Export disorders for ATP13A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATP13A3 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ATP13A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning the AFURS1 gene which is up-regulated in senescent human parenchymal kidney cells. (PubMed id 11867234)1, 2, 3 Habtemichael N. and Kovacs G. (Gene 2002)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79572 HGNC: 24113 AceView: AFURS1 Ensembl:ENSG00000133657 euGenes: HUgn79572
    ECgene: ATP13A3 H-InvDB: ATP13A3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATP13A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ATP13A3 gene:
    Search GeneIP for patents involving ATP13A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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