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Aliases for ATP12A Gene

Aliases for ATP12A Gene

  • ATPase, H+/K+ Transporting, Nongastric, Alpha Polypeptide 2 3
  • Proton Pump 2 3 4
  • ATP1AL1 3 4 6
  • ATPase, Na+/K+ Transporting, Alpha Polypeptide-Like 1 2 3
  • Potassium-Transporting ATPase Alpha Chain 2 2 3
  • Non-Gastric H(+)/K(+) ATPase Alpha Subunit 2 3
  • Non-Gastric H(+)/K(+) ATPase Subunit Alpha 3 4
  • EC 3.6.3.10 4 64
  • Alpha-1 Polypeptide-Like 2
  • Sodium/Potassium ATPase 2
  • Alpha Polypeptide-Like 2
  • Na+K+ Transporting 2
  • EC 3.6.3 64
  • ATPase 2

External Ids for ATP12A Gene

Previous Symbols for ATP12A Gene

  • ATP1AL1

Summaries for ATP12A Gene

Entrez Gene Summary for ATP12A Gene

  • The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for ATP12A Gene

ATP12A (ATPase, H+/K+ Transporting, Nongastric, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with ATP12A include dyskinesia of esophagus and gastric outlet obstruction. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP4A.

UniProtKB/Swiss-Prot for ATP12A Gene

  • Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues

Gene Wiki entry for ATP12A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP12A Gene

Genomics for ATP12A Gene

Genomic Location for ATP12A Gene

Start:
24,680,411 bp from pter
End:
24,712,493 bp from pter
Size:
32,083 bases
Orientation:
Plus strand

Genomic View for ATP12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP12A Gene

Regulatory Elements for ATP12A Gene

Proteins for ATP12A Gene

  • Protein details for ATP12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54707-AT12A_HUMAN
    Recommended name:
    Potassium-transporting ATPase alpha chain 2
    Protein Accession:
    P54707
    Secondary Accessions:
    • Q13816
    • Q13817
    • Q16734
    • Q5W035
    • Q8N5U2

    Protein attributes for ATP12A Gene

    Size:
    1039 amino acids
    Molecular mass:
    115511 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta

    Alternative splice isoforms for ATP12A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP12A Gene

Proteomics data for ATP12A Gene at MOPED

Post-translational modifications for ATP12A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys627, Lys640, and Lys713

Other Protein References for ATP12A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ATP12A Gene

Gene Families for ATP12A Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

UniProtKB/Swiss-Prot:

AT12A_HUMAN
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.:
    • P54707
genes like me logo Genes that share domains with ATP12A: view

Function for ATP12A Gene

Molecular function for ATP12A Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In)
UniProtKB/Swiss-Prot Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues

Enzyme Numbers (IUBMB) for ATP12A Gene

Gene Ontology (GO) - Molecular Function for ATP12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005391 sodium:potassium-exchanging ATPase activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008900 hydrogen:potassium-exchanging ATPase activity IEA --
genes like me logo Genes that share ontologies with ATP12A: view
genes like me logo Genes that share phenotypes with ATP12A: view

Animal Models for ATP12A Gene

MGI Knock Outs for ATP12A:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ATP12A Gene

Localization for ATP12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP12A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP12A Gene COMPARTMENTS Subcellular localization image for ATP12A gene
Compartment Confidence
plasma membrane 4
vacuole 3
cytosol 2
endoplasmic reticulum 2
endosome 2
extracellular 2
golgi apparatus 2
lysosome 2
mitochondrion 2
chloroplast 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005889 hydrogen:potassium-exchanging ATPase complex TAS 8838794
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with ATP12A: view

Pathways for ATP12A Gene

genes like me logo Genes that share pathways with ATP12A: view

Pathways by source for ATP12A Gene

Gene Ontology (GO) - Biological Process for ATP12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006754 ATP biosynthetic process --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport --
GO:0006885 regulation of pH IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ATP12A: view

Compounds for ATP12A Gene

(6) HMDB Compounds for ATP12A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Pantoprazole
  • Pantoloc
102625-70-7
Phosphate
  • NFB Orthophosphate
14265-44-2
Potassium
  • K+
7440-09-7

(3) Novoseek inferred chemical compound relationships for ATP12A Gene

Compound -log(P) Hits PubMed IDs
ouabain 58.9 2
hydrogen 23.2 1
potassium 23.1 2
genes like me logo Genes that share compounds with ATP12A: view

Transcripts for ATP12A Gene

mRNA/cDNA for ATP12A Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP12A Gene

ATPase, H+/K+ transporting, nongastric, alpha polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP12A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - -
SP2: -
SP3:

ExUns: 24b
SP1:
SP2:
SP3:

Relevant External Links for ATP12A Gene

GeneLoc Exon Structure for
ATP12A
ECgene alternative splicing isoforms for
ATP12A

Expression for ATP12A Gene

mRNA expression in normal human tissues for ATP12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP12A Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (15.7), Esophagus - Mucosa (10.5), Skin - Sun Exposed (Lower leg) (7.4), and Kidney - Cortex (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP12A Gene

SOURCE GeneReport for Unigene cluster for ATP12A Gene Hs.147111

mRNA Expression by UniProt/SwissProt for ATP12A Gene

P54707-AT12A_HUMAN
Tissue specificity: Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).
genes like me logo Genes that share expressions with ATP12A: view

Orthologs for ATP12A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP12A 36
  • 99.46 (n)
  • 99.52 (a)
ATP12A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP12A 36
  • 86.21 (n)
  • 87.6 (a)
ATP12A 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP12A 36
  • 88.09 (n)
  • 89.6 (a)
ATP12A 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp12a 36
  • 85.15 (n)
  • 86.96 (a)
Atp12a 16
Atp12a 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
-- 37
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATP12A 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp12a 36
  • 84.68 (n)
  • 86.39 (a)
chicken
(Gallus gallus)
Aves ATP12A 36
  • 76.51 (n)
  • 81.51 (a)
ATP12A 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP12A 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp12a 36
  • 64.81 (n)
  • 66.24 (a)
zebrafish
(Danio rerio)
Actinopterygii atp1a1a.3 37
  • 61 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Atpalpha 37
  • 62 (a)
OneToMany
Atpalpha 38
  • 63 (a)
CG17923 38
  • 54 (a)
CG3701 38
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea eat-6 37
  • 60 (a)
OneToMany
Y105E8A.12 38
  • 31 (a)
C02E7.1 38
  • 36 (a)
eat-6 38
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENA1 37
  • 26 (a)
ManyToMany
ENA2 37
  • 26 (a)
ManyToMany
ENA5 37
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToMany
Species with no ortholog for ATP12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP12A Gene

ENSEMBL:
Gene Tree for ATP12A (if available)
TreeFam:
Gene Tree for ATP12A (if available)

Paralogs for ATP12A Gene

Paralogs for ATP12A Gene

Selected SIMAP similar genes for ATP12A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ATP12A Gene

genes like me logo Genes that share paralogs with ATP12A: view

Variants for ATP12A Gene

Sequence variations from dbSNP and Humsavar for ATP12A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs2722 -- 24,711,630(+) ATTCA(G/T)ACAAG utr-variant-3-prime
rs724327 -- 24,698,117(+) AGACT(C/G)CTGTG intron-variant
rs724328 -- 24,698,470(+) AGAGT(C/G)GGTGC intron-variant
rs735769 -- 24,690,263(-) GCACC(A/G)AACCC intron-variant
rs735770 -- 24,690,231(-) TCCTG(A/G)TCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP12A Gene

Variant ID Type Subtype PubMed ID
nsv899941 CNV Gain 21882294
nsv832568 CNV Gain 17160897
nsv471124 CNV Gain 18288195
nsv455843 CNV Gain 19166990
esv2751140 CNV Gain 17911159
nsv528064 CNV Loss 19592680
esv2499767 CNV Deletion 19546169
esv1956864 CNV Deletion 18987734
esv3452 CNV Deletion 18987735
esv1009925 CNV Deletion 20482838
esv2747149 CNV Deletion 23290073
esv8208 CNV Loss 19470904
esv2747150 CNV Deletion 23290073
esv2747151 CNV Deletion 23290073

Relevant External Links for ATP12A Gene

HapMap Linkage Disequilibrium report
ATP12A

Disorders for ATP12A Gene

(1) Novoseek inferred disease relationships for ATP12A Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for ATP12A

Genetic Association Database (GAD)
ATP12A
Human Genome Epidemiology (HuGE) Navigator
ATP12A
genes like me logo Genes that share disorders with ATP12A: view

No data available for UniProtKB/Swiss-Prot for ATP12A Gene

Publications for ATP12A Gene

  1. Genomic organization of the human ATP1AL1 gene encoding a ouabain- sensitive H,K-ATPase. (PMID: 8838794) Sverdlov V.E. … Modyanov N.N. (Genomics 1996) 2 3 4 23
  2. The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase. (PMID: 1847115) Modyanov N.N. … Sverdlov E.D. (FEBS Lett. 1991) 3 4 23
  3. Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit. (PMID: 9872395) Pestov N.B. … Modyanov N.N. (FEBS Lett. 1998) 3 4 23
  4. Cloning and characterization of the entire cDNA encoded by ATP1AL1 -- a member of the human Na,K/H,K-ATPase gene family. (PMID: 8045293) Grishin A.V. … Modyanov N.N. (FEBS Lett. 1994) 3 4 23
  5. Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue. (PMID: 22179016) Streif D. … Ritter M. (Cell. Physiol. Biochem. 2011) 3 4

Products for ATP12A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ATP12A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ATP12A
    • Block miRNA regulation of ATP12A using miScript Target Protectors

    Sources for ATP12A Gene

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