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Aliases for ATP12A Gene

Aliases for ATP12A Gene

  • ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit 2 3
  • ATPase, H+/K+ Transporting, Nongastric, Alpha Polypeptide 2 3 5
  • Proton Pump 2 3 4
  • ATPase, Na+/K+ Transporting, Alpha Polypeptide-Like 1 2 3
  • Non-Gastric H(+)/K(+) ATPase Alpha Subunit 2 3
  • Non-Gastric H(+)/K(+) ATPase Subunit Alpha 3 4
  • EC 4 63
  • ATP1AL1 3 4
  • Potassium-Transporting ATPase Alpha Chain 2 2
  • Alpha-1 Polypeptide-Like 2
  • Sodium/Potassium ATPase 2
  • Alpha Polypeptide-Like 2
  • Na+K+ Transporting 2
  • EC 3.6.3 63
  • ATPase 2
  • #945 3
  • HK 3

External Ids for ATP12A Gene

Previous HGNC Symbols for ATP12A Gene

  • ATP1AL1

Previous GeneCards Identifiers for ATP12A Gene

  • GC13P023234
  • GC13P019234
  • GC13P024184
  • GC13P023052
  • GC13P024152
  • GC13P025254
  • GC13P006067

Summaries for ATP12A Gene

Entrez Gene Summary for ATP12A Gene

  • The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for ATP12A Gene

ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit) is a Protein Coding gene. Diseases associated with ATP12A include Chronic Laryngitis and Rumination Disorder. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Ion channel transport. GO annotations related to this gene include nucleotide binding and hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP4A.

UniProtKB/Swiss-Prot for ATP12A Gene

  • Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.

Gene Wiki entry for ATP12A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP12A Gene

Genomics for ATP12A Gene

Regulatory Elements for ATP12A Gene

Enhancers for ATP12A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP12A on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP12A Gene

24,680,411 bp from pter
24,712,493 bp from pter
32,083 bases
Plus strand

Genomic View for ATP12A Gene

Genes around ATP12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP12A Gene

Proteins for ATP12A Gene

  • Protein details for ATP12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Potassium-transporting ATPase alpha chain 2
    Protein Accession:
    Secondary Accessions:
    • Q13816
    • Q13817
    • Q16734
    • Q5W035
    • Q8N5U2

    Protein attributes for ATP12A Gene

    1039 amino acids
    Molecular mass:
    115511 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta.

    Alternative splice isoforms for ATP12A Gene


neXtProt entry for ATP12A Gene

Proteomics data for ATP12A Gene at MOPED

Post-translational modifications for ATP12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP12A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ATP12A Gene

Gene Families for ATP12A Gene

Suggested Antigen Peptide Sequences for ATP12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
genes like me logo Genes that share domains with ATP12A: view

Function for ATP12A Gene

Molecular function for ATP12A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.

Enzyme Numbers (IUBMB) for ATP12A Gene

genes like me logo Genes that share phenotypes with ATP12A: view

Animal Models for ATP12A Gene

MGI Knock Outs for ATP12A:

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP12A

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ATP12A Gene

Localization for ATP12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP12A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ATP12A Gene COMPARTMENTS Subcellular localization image for ATP12A gene
Compartment Confidence
plasma membrane 5
lysosome 3
vacuole 3
chloroplast 2
cytosol 2
endoplasmic reticulum 2
endosome 2
extracellular 2
golgi apparatus 2
mitochondrion 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ATP12A: view

Pathways & Interactions for ATP12A Gene

genes like me logo Genes that share pathways with ATP12A: view

Pathways by source for ATP12A Gene

Gene Ontology (GO) - Biological Process for ATP12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport IEA --
GO:0006883 cellular sodium ion homeostasis IBA --
GO:0006885 regulation of pH IEA --
GO:0008152 metabolic process IEA --
GO:0010107 potassium ion import IBA --
genes like me logo Genes that share ontologies with ATP12A: view

No data available for SIGNOR curated interactions for ATP12A Gene

Drugs & Compounds for ATP12A Gene

(4) Drugs for ATP12A Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pantoprazole Approved Pharma 168
Adenosine triphosphate Approved Nutra 0
Potassium Experimental Pharma 0

(4) Additional Compounds for ATP12A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with ATP12A: view

Transcripts for ATP12A Gene

mRNA/cDNA for ATP12A Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP12A Gene

ATPase, H+/K+ transporting, nongastric, alpha polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP12A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - -
SP2: -

ExUns: 24b

Relevant External Links for ATP12A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP12A Gene

mRNA expression in normal human tissues for ATP12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP12A Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.7), Esophagus - Mucosa (x10.5), Skin - Sun Exposed (Lower leg) (x7.4), and Kidney - Cortex (x6.8).

Protein differential expression in normal tissues from HIPED for ATP12A Gene

This gene is overexpressed in Brain (18.4) and Nasal epithelium (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP12A Gene

SOURCE GeneReport for Unigene cluster for ATP12A Gene Hs.147111

mRNA Expression by UniProt/SwissProt for ATP12A Gene

Tissue specificity: Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).
genes like me logo Genes that share expression patterns with ATP12A: view

Primer Products

No data available for Protein tissue co-expression partners for ATP12A Gene

Orthologs for ATP12A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP12A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATP12A 35
  • 86.21 (n)
  • 87.6 (a)
ATP12A 36
  • 82 (a)
(Canis familiaris)
Mammalia ATP12A 35
  • 88.09 (n)
  • 89.6 (a)
ATP12A 36
  • 85 (a)
(Mus musculus)
Mammalia Atp12a 35
  • 85.15 (n)
  • 86.96 (a)
Atp12a 16
Atp12a 36
  • 87 (a)
(Pan troglodytes)
Mammalia ATP12A 35
  • 99.46 (n)
  • 99.52 (a)
ATP12A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Atp12a 35
  • 84.68 (n)
  • 86.39 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
-- 36
  • 78 (a)
-- 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ATP12A 36
  • 87 (a)
(Gallus gallus)
Aves ATP12A 35
  • 76.51 (n)
  • 81.51 (a)
ATP12A 36
  • 82 (a)
(Anolis carolinensis)
Reptilia ATP12A 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atp12a 35
  • 64.81 (n)
  • 66.24 (a)
(Danio rerio)
Actinopterygii atp1a1a.3 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atpalpha 37
  • 63 (a)
CG17923 37
  • 54 (a)
CG3701 37
  • 29 (a)
Atpalpha 36
  • 62 (a)
(Caenorhabditis elegans)
Secernentea C02E7.1 37
  • 36 (a)
eat-6 37
  • 59 (a)
Y105E8A.12 37
  • 31 (a)
eat-6 36
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENA1 36
  • 26 (a)
ENA2 36
  • 26 (a)
ENA5 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for ATP12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP12A Gene

Gene Tree for ATP12A (if available)
Gene Tree for ATP12A (if available)

Paralogs for ATP12A Gene

Paralogs for ATP12A Gene

(6) SIMAP similar genes for ATP12A Gene using alignment to 1 proteins: Pseudogenes for ATP12A Gene

genes like me logo Genes that share paralogs with ATP12A: view

Variants for ATP12A Gene

Sequence variations from dbSNP and Humsavar for ATP12A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2289909 - 24,709,458(+) CCAGC(A/C/T)GCTCG reference, missense
rs2722 -- 24,711,630(+) ATTCA(G/T)ACAAG utr-variant-3-prime
rs895423 -- 24,709,356(-) AGAGG(A/G)GAAGA intron-variant
rs895424 -- 24,689,754(-) TCCCC(A/G)CCAAA intron-variant
rs895425 -- 24,689,714(-) TCACA(G/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP12A Gene

Variant ID Type Subtype PubMed ID
nsv899941 CNV Gain 21882294
nsv832568 CNV Gain 17160897
nsv471124 CNV Gain 18288195
nsv455843 CNV Gain 19166990
esv2751140 CNV Gain 17911159
nsv528064 CNV Loss 19592680
esv2499767 CNV Deletion 19546169
esv1956864 CNV Deletion 18987734
esv3452 CNV Deletion 18987735
esv1009925 CNV Deletion 20482838
esv2747149 CNV Deletion 23290073
esv8208 CNV Loss 19470904
esv2747150 CNV Deletion 23290073
esv2747151 CNV Deletion 23290073

Variation tolerance for ATP12A Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.79; 66.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATP12A Gene

Disorders for ATP12A Gene

MalaCards: The human disease database

(40) MalaCards diseases for ATP12A Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic laryngitis
rumination disorder
  • psychogenic rumination
hiatus hernia
  • diaphragmatic - hiatus -hernia
bladder calculus
  • urinary bladder calculi
functional gastric disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ATP12A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ATP12A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP12A Gene

Publications for ATP12A Gene

  1. Genomic organization of the human ATP1AL1 gene encoding a ouabain- sensitive H,K-ATPase. (PMID: 8838794) Sverdlov V.E. … Modyanov N.N. (Genomics 1996) 2 3 4 23 67
  2. The putative role of the non-gastric Ha8_/Ka8_-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the Ha8_/Ka8_ ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells. (PMID: 25322912) Jakab M. … Ritter M. (Cell. Physiol. Biochem. 2014) 2 3
  3. Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast. (PMID: 15135233) Johansson M. … Powell T.L. (Placenta 2004) 3 23
  4. Expression of ATP1AL1, a non-gastric proton pump, in human colorectum. (PMID: 12230809) Takahashi Y. … Takeguchi N. (Jpn. J. Physiol. 2002) 3 23
  5. Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit. (PMID: 9872395) Pestov N.B. … Modyanov N.N. (FEBS Lett. 1998) 3 23

Products for ATP12A Gene

Sources for ATP12A Gene