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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP12A Gene

protein-coding   GIFtS: 61
GCID: GC13P025254

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

(Previous names: ATPase, Na+/K+ transporting, alpha polypeptide-like 1 )
(Previous symbol: ATP1AL1)
 Explore 29 diseases affiliated with
ATP12A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATP12A    

Aliases
for ATP12A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATPase, H+/K+ Transporting, Nongastric, Alpha Polypeptide1 2     EC 3.6.3.103 8
ATP1AL11 2 3 5     Non-Gastric H(+)/K(+) ATPase Alpha Subunit2
ATPase, Na+/K+ Transporting, Alpha Polypeptide-Like 11 2     Potassium-Transporting ATPase Alpha Chain 22
Non-Gastric H(+)/K(+) ATPase Subunit Alpha2 3     EC 3.6.38
Proton Pump2 3     

External Ids:    HGNC: 138161   Entrez Gene: 4792   Ensembl: ENSG000000756737   OMIM: 1823605   UniProtKB: P547073   

Export aliases for ATP12A gene to outside databases

Previous GC identifers: GC13P023234 GC13P019234 GC13P024184 GC13P023052 GC13P024152 GC13P006067


Summaries
for ATP12A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ATP12A:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a
catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the
exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various
tissues. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun
2010)

UniProtKB/Swiss-Prot: AT12A_HUMAN, P54707
Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane.
Responsible for potassium absorption in various tissues

Gene Wiki entry for ATP12A


Genomic Views
for ATP12A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP12A gene promoter:
         GR   ISGF-3   Sox5   GR-beta   MZF-1   POU2F1   POU2F1a   GR-alpha   LyF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP12A promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP12A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.12|13q12.1-q12.3   Ensembl cytogenetic band:  13q12.12   HGNC cytogenetic band: 13q11-q12.1

ATP12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP12A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P025254:  view genomic region     (about GC identifiers)

Start:
 25,254,549 bp from pter      End:
 25,285,923 bp from pter
Size:
 31,375 bases      Orientation:
 plus strand

Proteins
for ATP12A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AT12A_HUMAN, P54707 (See protein sequence)
Recommended Name: Potassium-transporting ATPase alpha chain 2  
Size: 1039 amino acids; 115511 Da
Subunit: Composed of two subunits: alpha (catalytic) and beta
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q13816 Q13817 Q16734 Q5W035 Q8N5U2
Alternative splicing: 2 isoforms:  P54707-1   P54707-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP12A: NX_P54707

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54707

    • 4/37 DME Specific Peptides for ATP12A (P54707) (see all 37)
     AVETLGS  DDNFASI  SSLTGES  PFNSTNK 

    ATP12A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001172014.1  NP_001667.4  

    ENSEMBL proteins: 
     ENSP00000371372   ENSP00000218548  
    Reactome Protein details: P54707
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    Novus Biologicals ATP12A Protein
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    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005889hydrogen:potassium-exchanging ATPase complex TAS8838794
    GO:0016323basolateral plasma membrane IEA--
    GO:0016324apical plasma membrane ----


    ATP12A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ATP12A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATP12A for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR023298 ATPase_P-typ_TM_dom
     IPR023306 ATPase_cation_domN
     IPR005775 ATPase_P-typ_Na/K
     IPR023299 ATPase_P-typ_cyto_domN
     IPR008250 ATPase_P-typ_transduc_dom_A

    Graphical View of Domain Structure for InterPro Entry P54707

    ProtoNet protein and cluster: P54707

    4 Blocks protein families:
    IPB001757 ATPase
    IPB006068 Cation transporting ATPase
    IPB006069 Sodium/potassium-transporting ATPase signature
    IPB008250 E1-E2 ATPase-associated region


    UniProtKB/Swiss-Prot: AT12A_HUMAN, P54707
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily


    Function
    for ATP12A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AT12A_HUMAN, P54707
    Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane.
    Responsible for potassium absorption in various tissues
    Catalytic activity: ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In)

    Enzyme Numbers (IUBMB): EC 3.6.3.101 2 EC 3.6.32

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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0008900hydrogen:potassium-exchanging ATPase activity IEA--
    GO:0046872metal ion binding IEA--


    ATP12A for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Atp12atm1Ges for ATP12A
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atp12a):
     digestive/alimentary  growth/size  homeostasis/metabolism  renal/urinary system 

    ATP12A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATP12A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Ion transport by P-type ATPases0.32
    2Sodium-coupled transporters and pumps
    		Sodium-coupled transporters and pumps1.00
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Oxidative phosphorylation0.63
    4SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ATP12A
        Sodium-coupled transporters and pumps


    3        Reactome Pathways for ATP12A
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases


    1         Kegg Pathway  (Kegg details for ATP12A):
        Oxidative phosphorylation


    ATP12A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP12A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ATP12A (P547073 ENSP000003713724) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMEP084733, ENSP000003536794I2D: score=2 STRING: ENSP00000353679
    ATP4AENSP000002626234STRING: ENSP00000262623
    ATP4BENSP000003342164STRING: ENSP00000334216
    PPA1ENSP000003623294STRING: ENSP00000362329
    LHPPENSP000003578354STRING: ENSP00000357835
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006754ATP biosynthetic process IEA--
    GO:0006885regulation of pH IEA--
    GO:0010038response to metal ion ----
    GO:0014070response to organic cyclic compound ----
    GO:0030001metal ion transport ----


    ATP12A for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATP12A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATP12A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ATP12A

    6 HMDB Compounds for ATP12A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PantoprazolePantoloc (see all 6)102625-70-7--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    PotassiumK+ (see all 16)7440-09-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    3 Novoseek chemical compound relationships for ATP12A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ouabain 58.9 2 9774385 (1), 7485470 (1)
    hydrogen 23.2 1 7485470 (1)
    potassium 23.1 2 7485470 (1), 9872395 (1)

    Search CenterWatch for drugs/clinical trials and news about ATP12A / AT12A 

    Transcripts
    for ATP12A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATP12A gene (2 alternative transcripts): 
    NM_001185085.1  NM_001676.5  

    Unigene Cluster for ATP12A:

    ATPase, H+/K+ transporting, nongastric, alpha polypeptide
    Hs.147111  [show with all ESTs]
    Unigene Representative Sequence: NM_001185085
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381946 ENST00000218548(uc001upp.3 uc010aaa.3)

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK292968.1 AK303498.1 BC031609.1 M16797.1 U02076.1 

    5 DOTS entries:

    DT.97816830  DT.206242  DT.100775534  DT.75195070  DT.91740316 

    16 AceView cDNA sequences:

    NM_001676 CA450333 M16797 BC031609 BG182394 U02076 BX369338 BF512669 
    BX105429 BX382083 CD612453 BX369337 BU682695 AA366996 BM982192 AI190608 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ATP12A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
    SP1:              -                                         -                                                                                                   
    SP2:              -                                                                                                                                             
    SP3:                                                                                                                                                            

    ExUns: 24b
    SP1:      
    SP2:      
    SP3:      


    ECgene alternative splicing isoforms for ATP12A

    Expression
    for ATP12A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP12A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAAAGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ATP12A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Trophoblast-like cells (Generation of tropho...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ATP12A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP12A

    SOURCE GeneReport for Unigene cluster: Hs.147111

    UniProtKB/Swiss-Prot: AT12A_HUMAN, P54707
    Tissue specificity: Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is
    increased in benign prostate hyperplasia and tumor tissues (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including ATP12A: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
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    Orthologs
    for ATP12A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ATP12A gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ATP12A1 ATPase, H+/K+ transporting, nongastric, alpha polypeptide 76.51(n)
    81.51(a)    		   419743  NM_001030909.1  NP_001026080.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ATP12A6
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343396.1(61-15018)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC045045.12   -- 75.78(n)    BC045045.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Atpalpha3 cation transport sodium/potassium-exchanging
    ATPase    		 63(a)
    (best of 3)    		   93B2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea eat-63 Na(+)/K(+) ATPase alpha subunit 59(a)
    (best of 3)    		   V(13129245-13132586)   --


    ENSEMBL Gene Tree for ATP12A (if available)
    TreeFam Gene Tree for ATP12A (if available) 

    Paralogs
    for ATP12A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP12A gene
    ATP2C12  ATP2A32  ATP1A22  ATP2C22  ATP1A42  ATP2A12  ATP4A2  ATP1A32  
    ATP2A22  ATP1A12  
    6 SIMAP similar genes for ATP12A using alignment to 1 protein entry:     AT12A_HUMAN:
    DKFZp666G172    ATP1A3    ATP1A1    ATP1A2    ATP4A    ATP1A4

    ATP12A for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ATP12A
    PGOHUM00000240326 PGOHUM00000240916 PGOHUM00000241107


    Genomic Variants
    for ATP12A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/798 NCBI SNPs in ATP12A are shown (see all 798)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs619480691,2
    		C,F,unknown25255503(+) TACACA/G/TGACGG 2 -- int16NA CSA WA EA 364
    rs1845130361,2
    		--25252557(+) GAGAGC/TGGGGA 2 -- us2k10--------
    rs1431602901,2
    		--25252604(+) TATGTC/TGGGTA 2 -- us2k10--------
    rs559316281,2
    		C--25252663(+) GTGGAA/GAATCT 2 -- us2k10--------
    rs1892261891,2
    		--25252809(+) TCATGC/TTCTGA 2 -- us2k10--------
    rs2009639151,2
    		--25252896(+) TTTTT-/TCTTATT 2 -- us2k10--------
    rs1464530111,2
    		C,--25252897(+) TTTTT-/CTTATT 2 -- us2k10--------
    rs1995940791,2
    		--25252927(+) GTGAC-/AAGAGT 2 -- us2k10--------
    rs37594551,2
    		C,F,H,--25253077(-) CAAAAA/CAATTA 2 -- us2k15Minor allele frequency- C:0.20NA WA 10
    rs344398081,2
    		C,--25253098(+) AGAGAC/TGGGGT 2 -- us2k12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for ATP12A (25254549 - 25285923 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for ATP12A
         2 CNVs: 101679 8750
         3 Indels: 42664 61302 45147

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    Disorders / Diseases
    for ATP12A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATP12A for disorders           About GeneDecksing

    OMIM gene information: 182360    OMIM disorders: --

    20/29 diseases for ATP12A (see all 29):    About MalaCards
    gastric antral vascular ectasia    hiatus hernia    duodenogastric reflux    renal tubular acidosis
    gastric outlet obstruction    gastroesophageal reflux disease    bile reflux    irritable bowel syndrome
    interstitial nephritis    peptic ulcer    dyskinesia of esophagus    achalasia
    dyspepsia    osteopetrosis    constipation    stomach cancer
    hernia    diarrhea    gastritis    nephritis

    20/22 diseases from the University of Copenhagen DISEASES database for ATP12A (see all 22):
    Gastroesophageal reflux disease     Peptic ulcer     Esophagitis     Dyspepsia
    Hiatus hernia     Gastritis     Laryngitis     Diarrhea
    Achalasia     Bile reflux     Gastrinoma     Dyskinesia of esophagus
    Pneumonia     Duodenitis     Carcinoma     Asthma
    Esophageal cancer     Gastric outlet obstruction     Stomach cancer     Irritable bowel syndrome

    1 Novoseek disease relationship for ATP12A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 12230809 (1)

    Human Genome Epidemiology (HuGE) Navigator: ATP12A (2 documents)

    Export disorders for ATP12A gene to outside databases

    Publications
    for ATP12A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP12A gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with ATP12A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human ATP1AL1 gene encoding a ouabain- sensitive H,K-ATPase. (PubMed id 8838794)1, 2, 3, 9 Sverdlov V.E.... Modyanov N.N. (1996)
    2. Cloning and characterization of the entire cDNA encoded by ATP1AL1 -- a member of the human Na,K/H,K-ATPase gene family. (PubMed id 8045293)1, 2, 9 Grishin A.V.... Modyanov N.N. (1994)
    3. The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase. (PubMed id 1847115)1, 2, 9 Modyanov N.N.... Sverdlov E.D. (1991)
    4. Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit. (PubMed id 9872395)1, 2, 9 Pestov N.B.... Modyanov N.N. (1998)
    5. Expression of the non-gastric H+/K+ ATPase ATP12A in n ormal and pathological human prostate tissue. (PubMed id 22179016)1, 2 Streif D....Ritter M. (2011)
    6. Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. (PubMed id 2842249)1, 3 Yang-Feng T.L....Francke U. (1988)
    7. Multiple genes encode the human Na+,K+-ATPase catalytic subunit. (PubMed id 3035563)1, 2 Shull M.M. and Lingrel J.B. (1987)
    8. The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. (PubMed id 3036582)1, 2 Sverdlov E.D.... Ovchinnikov Y.A. (1987)
    9. Expression of ATP1AL1, a non-gastric proton pump, in human colorectum. (PubMed id 12230809)1, 9 Takahashi Y....Takeguchi N. (2002)
    10. Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast. (PubMed id 15135233)1, 9 Johansson M....Powell T.L. (2004)

    External Searches for ATP12A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
    Disorders
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    Genome Databases showing ATP12A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 479 HGNC: 13816 AceView: ATP12A Ensembl:ENSG00000075673 euGenes: HUgn479
    ECgene: ATP12A Kegg: 479 H-InvDB: ATP12A

    Other Databases showing ATP12A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATP12A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP12A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATP12A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATP12A gene:
    Search GeneIP for patents involving ATP12A

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