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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP12A Gene

protein-coding   GIFtS: 63
GCID: GC13P025254

ATPase, H+/K+ Transporting, Nongastric, Alpha Polypeptide

(Previous names: ATPase, Na+/K+ transporting, alpha polypeptide-like 1)
(Previous symbol: ATP1AL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATPase, H+/K+ Transporting, Nongastric, Alpha Polypeptide1 2     EC 3.6.3.103 8
ATP1AL11 2 3 5     ATPase1
Proton Pump1 2 3     Alpha Polypeptide-Like1
ATPase, Na+/K+ Transporting, Alpha Polypeptide-Like 11 2     Alpha-1 Polypeptide-Like1
Non-Gastric H(+)/K(+) ATPase Alpha Subunit1 2     Na+K+ Transporting1
Potassium-Transporting ATPase Alpha Chain 21 2     Sodium/Potassium ATPase1
Non-Gastric H(+)/K(+) ATPase Subunit Alpha2 3     EC 3.6.38

External Ids:    HGNC: 138161   Entrez Gene: 4792   Ensembl: ENSG000000756737   OMIM: 1823605   UniProtKB: P547073   

Export aliases for ATP12A gene to outside databases

Previous GC identifers: GC13P023234 GC13P019234 GC13P024184 GC13P023052 GC13P024152 GC13P006067


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATP12A Gene:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a
catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the
exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in
various tissues. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jun 2010)

GeneCards Summary for ATP12A Gene: 
ATP12A (ATPase, H+/K+ transporting, nongastric, alpha polypeptide) is a protein-coding gene. Diseases associated with ATP12A include dyskinesia of esophagus, and gastric outlet obstruction, and among its related super-pathways are Ion channel transport and Electron Transport Chain. GO annotations related to this gene include metal ion binding and hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP1A2.

UniProtKB/Swiss-Prot: AT12A_HUMAN, P54707
Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma
membrane. Responsible for potassium absorption in various tissues

Gene Wiki entry for ATP12A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP12A gene promoter:
         GR   ISGF-3   Sox5   GR-beta   MZF-1   POU2F1   POU2F1a   GR-alpha   LyF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP12A promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP12A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.12|13q12.1-q12.3   Ensembl cytogenetic band:  13q12.12   HGNC cytogenetic band: 13q11-q12.1

ATP12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP12A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P025254:  view genomic region     (about GC identifiers)

Start:
25,254,549 bp from pter      End:
25,285,923 bp from pter
Size:
31,375 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AT12A_HUMAN, P54707 (See protein sequence)
Recommended Name: Potassium-transporting ATPase alpha chain 2  
Size: 1039 amino acids; 115511 Da
Subunit: Composed of two subunits: alpha (catalytic) and beta
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q13816 Q13817 Q16734 Q5W035 Q8N5U2
Alternative splicing: 2 isoforms:  P54707-1   P54707-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP12A: NX_P54707

Explore proteomics data for ATP12A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54707

  • 4/37 DME Specific Peptides for ATP12A (P54707) (see all 37)
     AVETLGS  DDNFASI  SSLTGES  PFNSTNK 

    ATP12A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATP12A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001172014.1  NP_001667.4  

    ENSEMBL proteins: 
     ENSP00000371372   ENSP00000218548  
    Reactome Protein details: P54707
    Human Recombinant Protein Products for ATP12A: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005889hydrogen:potassium-exchanging ATPase complex TAS8838794
    GO:0016021integral to membrane ----
    GO:0016323basolateral plasma membrane IEA--

    ATP12A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PATP: ATPases / P-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: ATP12A 
    H+/K+-ATPase

    5/9 InterPro protein domains (see all 9):
     IPR023298 ATPase_P-typ_TM_dom
     IPR005775 ATPase_P-typ_Na/K_IIC
     IPR023299 ATPase_P-typ_cyto_domN
     IPR008250 ATPase_P-typ_transduc_dom_A
     IPR023214 HAD-like_dom

    Graphical View of Domain Structure for InterPro Entry P54707

    ProtoNet protein and cluster: P54707

    4 Blocks protein domains:
    IPB001757 ATPase
    IPB006068 Cation transporting ATPase
    IPB006069 Sodium/potassium-transporting ATPase signature
    IPB008250 E1-E2 ATPase-associated region


    UniProtKB/Swiss-Prot: AT12A_HUMAN, P54707
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily


    ATP12A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT12A_HUMAN, P54707
    Function: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma
    membrane. Responsible for potassium absorption in various tissues
    Catalytic activity: ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In)

         Enzyme Numbers (IUBMB): EC 3.6.3.101 2 EC 3.6.32

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008900hydrogen:potassium-exchanging ATPase activity IEA--
    GO:0015077monovalent inorganic cation transmembrane transporter activity ----
         
    ATP12A for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atp12a):
     digestive/alimentary  growth/size  homeostasis/metabolism  renal/urinary system 

    ATP12A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Atp12atm1Ges for ATP12A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ATP12A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATP12A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.49
    Ion transport by P-type ATPases0.32
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Oxidative phosphorylation0.64
    3SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    4Sodium-coupled transporters and pumps
    Sodium-coupled transporters and pumps0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ATP12A
        Sodium-coupled transporters and pumps


    3        Reactome Pathways for ATP12A
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases


    1         Kegg Pathway  (Kegg details for ATP12A):
        Oxidative phosphorylation


    ATP12A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP12A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ATP12A (P547073 ENSP000003713724) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMEP084733, ENSP000003536794I2D: score=2 STRING: ENSP00000353679
    ATP4AENSP000002626234STRING: ENSP00000262623
    ATP4BENSP000003342164STRING: ENSP00000334216
    PPA1ENSP000003623294STRING: ENSP00000362329
    LHPPENSP000003578354STRING: ENSP00000357835
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006754ATP biosynthetic process IEA--
    GO:0006812cation transport ----
    GO:0006885regulation of pH IEA--
    GO:0015672monovalent inorganic cation transport ----
    GO:0034220ion transmembrane transport TAS--

    ATP12A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATP12A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ATP12A (AT12A)

    6 HMDB Compounds for ATP12A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PantoprazolePantoloc (see all 6)102625-70-7--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    PotassiumK+ (see all 16)7440-09-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 Novoseek inferred chemical compound relationships for ATP12A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ouabain 58.9 2 9774385 (1), 7485470 (1)
    hydrogen 23.2 1 7485470 (1)
    potassium 23.1 2 7485470 (1), 9872395 (1)

    Search CenterWatch for drugs/clinical trials and news about ATP12A / AT12A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATP12A gene (2 alternative transcripts): 
    NM_001185085.1  NM_001676.5  

    Unigene Cluster for ATP12A:

    ATPase, H+/K+ transporting, nongastric, alpha polypeptide
    Hs.147111  [show with all ESTs]
    Unigene Representative Sequence: NM_001185085
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381946 ENST00000218548(uc001upp.3 uc010aaa.3)

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    Additional mRNA sequence: 

    AK292968.1 AK303498.1 BC031609.1 M16797.1 U02076.1 

    5 DOTS entries:

    DT.97816830  DT.206242  DT.100775534  DT.75195070  DT.91740316 

    16 AceView cDNA sequences:

    NM_001676 U02076 M16797 BC031609 CA450333 BG182394 BF512669 BX382083 
    BM982192 AA366996 BU682695 BX369337 BX105429 BX369338 CD612453 AI190608 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ATP12A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
    SP1:              -                                         -                                                                                                   
    SP2:              -                                                                                                                                             
    SP3:                                                                                                                                                            

    ExUns: 24b
    SP1:      
    SP2:      
    SP3:      


    ECgene alternative splicing isoforms for ATP12A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP12A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAAAGCTG
    ATP12A Expression
    About this image


    See ATP12A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP12A

    SOURCE GeneReport for Unigene cluster: Hs.147111

    UniProtKB/Swiss-Prot: AT12A_HUMAN, P54707
    Tissue specificity: Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is
    increased in benign prostate hyperplasia and tumor tissues (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including ATP12A: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP12A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ATP12A gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp12a1 , 5 ATPase, H+/K+ transporting, nongastric, alpha polypeptide1, 5 85.12(n)1
    86.96(a)1
      14 (28.19 cM)5
    1921131  NM_138652.21  NP_619593.21 
     563650685 
    chicken
    (Gallus gallus)
    Aves ATP12A1 ATPase, H+/K+ transporting, nongastric, alpha polypeptide 76.51(n)
    81.51(a)
      419743  NM_001030909.1  NP_001026080.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATP12A6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343396.1(25-15248)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045045.12   -- 75.78(n)    BC045045.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atpalpha3 cation transport
    sodium/potassium-exchanging ATPase
    63(a)
    (best of 3)
      93B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea eat-63 Na(+)/K(+) ATPase alpha subunit 59(a)
    (best of 3)
      V(13129245-13132586)   --


    ENSEMBL Gene Tree for ATP12A (if available)
    TreeFam Gene Tree for ATP12A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP12A gene
    ATP1A22  ATP1A42  ATP1A12  ATP4A2  ATP1A32  
    6 SIMAP similar genes for ATP12A using alignment to 1 protein entry:     AT12A_HUMAN:
    ATP1A3    DKFZp666G172    ATP1A1    ATP1A2    ATP4A    ATP1A4

    ATP12A for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ATP12A
    PGOHUM00000240326 PGOHUM00000240916 PGOHUM00000241107


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/973 SNPs in ATP12A are shown (see all 973)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs619480691,2
    C,Funtested125255503(+) TACACA/G/TGACGG 2 -- int16NA CSA WA EA 364
    rs1845130361,2
    --25252557(+) GAGAGC/TGGGGA 2 -- us2k10--------
    rs1431602901,2
    C--25252604(+) TATGTC/TGGGTA 2 -- us2k10--------
    rs559316281,2
    C--25252663(+) GTGGAA/GAATCT 2 -- us2k10--------
    rs1892261891,2
    --25252809(+) TCATGC/TTCTGA 2 -- us2k10--------
    rs2009639151,2
    --25252896(+) TTTTT-/TCTTATT 2 -- us2k10--------
    rs1464530111,2
    C--25252897(+) TTTTT-/CTTATT 2 -- us2k10--------
    rs1995940791,2
    C--25252927(+) TGTGA-/AGAGTC 2 -- us2k10--------
    rs37594551,2
    C,F,H--25253077(-) CAAAAA/CAATTA 2 -- us2k15Minor allele frequency- C:0.20NA WA 10
    rs344398081,2
    C--25253098(+) AGAGAC/TGGGGT 2 -- us2k12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for ATP12A (25254549 - 25285923 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for ATP12A (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1956864CNV Deletion18987734
    esv3452CNV Deletion18987735
    esv1009925CNV Deletion20482838
    esv2747151CNV Deletion23290073
    esv2499767CNV Deletion19546169
    esv2747150CNV Deletion23290073
    esv2747149CNV Deletion23290073
    nsv528064CNV Loss19592680
    esv8208CNV Loss19470904
    esv2751140CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182360    OMIM disorders: --

    20/27 diseases for ATP12A (see all 27):    About MalaCards
    dyskinesia of esophagus    gastric outlet obstruction    gastric antral vascular ectasia    bile reflux
    hiatus hernia    duodenogastric reflux    achalasia    interstitial nephritis
    dyspepsia    gastrinoma    gastroesophageal reflux disease    constipation
    renal tubular acidosis    pharyngitis    hernia    peptic ulcer
    irritable bowel syndrome    stomach cancer    osteopetrosis    nephritis

    20/22 diseases from the University of Copenhagen DISEASES database for ATP12A (see all 22):
    Gastroesophageal reflux disease     Peptic ulcer     Esophagitis     Dyspepsia
    Hiatus hernia     Gastritis     Laryngitis     Diarrhea
    Achalasia     Bile reflux     Gastrinoma     Dyskinesia of esophagus
    Pneumonia     Carcinoma     Duodenitis     Asthma
    Esophageal cancer     Gastric outlet obstruction     Irritable bowel syndrome     Stomach cancer

    ATP12A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for ATP12A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 12230809 (1)

    Genetic Association Database (GAD): ATP12A
    Human Genome Epidemiology (HuGE) Navigator: ATP12A (2 documents)

    Export disorders for ATP12A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP12A gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with ATP12A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human ATP1AL1 gene encoding a ouabain- sensitive H,K-ATPase. (PubMed id 8838794)1, 2, 3, 9 Sverdlov V.E.... Modyanov N.N. (1996)
    2. Cloning and characterization of the entire cDNA encoded by ATP1AL1 -- a member of the human Na,K/H,K-ATPase gene family. (PubMed id 8045293)1, 2, 9 Grishin A.V.... Modyanov N.N. (1994)
    3. The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase. (PubMed id 1847115)1, 2, 9 Modyanov N.N.... Sverdlov E.D. (1991)
    4. Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit. (PubMed id 9872395)1, 2, 9 Pestov N.B.... Modyanov N.N. (1998)
    5. Expression of the non-gastric H+/K+ ATPase ATP12A in n ormal and pathological human prostate tissue. (PubMed id 22179016)1, 2 Streif D....Ritter M. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. (PubMed id 2842249)1, 3 Yang-Feng T.L....Francke U. (1988)
    8. Multiple genes encode the human Na+,K+-ATPase catalytic subunit. (PubMed id 3035563)1, 2 Shull M.M. and Lingrel J.B. (1987)
    9. The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. (PubMed id 3036582)1, 2 Sverdlov E.D.... Ovchinnikov Y.A. (1987)
    10. Expression of ATP1AL1, a non-gastric proton pump, in human colorectum. (PubMed id 12230809)1, 9 Takahashi Y....Takeguchi N. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 479 HGNC: 13816 AceView: ATP12A Ensembl:ENSG00000075673 euGenes: HUgn479
    ECgene: ATP12A Kegg: 479 H-InvDB: ATP12A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP12A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATP12A gene:
    Search GeneIP for patents involving ATP12A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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