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Aliases for ATP12A Gene

Aliases for ATP12A Gene

  • ATPase, H+/K+ Transporting, Nongastric, Alpha Polypeptide 2 3
  • Proton Pump 2 3 4
  • ATPase, Na+/K+ Transporting, Alpha Polypeptide-Like 1 2 3
  • Non-Gastric H(+)/K(+) ATPase Alpha Subunit 2 3
  • Non-Gastric H(+)/K(+) ATPase Subunit Alpha 3 4
  • EC 3.6.3.10 4 63
  • ATP1AL1 3 4
  • Potassium-Transporting ATPase Alpha Chain 2 2
  • Alpha-1 Polypeptide-Like 2
  • Sodium/Potassium ATPase 2
  • Alpha Polypeptide-Like 2
  • Na+K+ Transporting 2
  • EC 3.6.3 63
  • ATPase 2

External Ids for ATP12A Gene

Previous HGNC Symbols for ATP12A Gene

  • ATP1AL1

Previous GeneCards Identifiers for ATP12A Gene

  • GC13P023234
  • GC13P019234
  • GC13P024184
  • GC13P023052
  • GC13P024152
  • GC13P025254
  • GC13P006067

Summaries for ATP12A Gene

Entrez Gene Summary for ATP12A Gene

  • The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for ATP12A Gene

ATP12A (ATPase, H+/K+ Transporting, Nongastric, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with ATP12A include rumination disorder and bladder calculus. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include nucleotide binding and hydrogen:potassium-exchanging ATPase activity. An important paralog of this gene is ATP4A.

UniProtKB/Swiss-Prot for ATP12A Gene

  • Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues

Gene Wiki entry for ATP12A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP12A Gene

Genomics for ATP12A Gene

Regulatory Elements for ATP12A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP12A Gene

Chromosome:
13
Start:
24,680,411 bp from pter
End:
24,712,493 bp from pter
Size:
32,083 bases
Orientation:
Plus strand

Genomic View for ATP12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP12A Gene

Proteins for ATP12A Gene

  • Protein details for ATP12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54707-AT12A_HUMAN
    Recommended name:
    Potassium-transporting ATPase alpha chain 2
    Protein Accession:
    P54707
    Secondary Accessions:
    • Q13816
    • Q13817
    • Q16734
    • Q5W035
    • Q8N5U2

    Protein attributes for ATP12A Gene

    Size:
    1039 amino acids
    Molecular mass:
    115511 Da
    Quaternary structure:
    • Composed of two subunits: alpha (catalytic) and beta

    Alternative splice isoforms for ATP12A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP12A Gene

Proteomics data for ATP12A Gene at MOPED

Post-translational modifications for ATP12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP12A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ATP12A Gene

Gene Families for ATP12A Gene

HGNC:
IUPHAR :

Suggested Antigen Peptide Sequences for ATP12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54707

UniProtKB/Swiss-Prot:

AT12A_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
genes like me logo Genes that share domains with ATP12A: view

Function for ATP12A Gene

Molecular function for ATP12A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In)
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues

Enzyme Numbers (IUBMB) for ATP12A Gene

Gene Ontology (GO) - Molecular Function for ATP12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005391 sodium:potassium-exchanging ATPase activity IBA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008900 hydrogen:potassium-exchanging ATPase activity IBA --
genes like me logo Genes that share ontologies with ATP12A: view
genes like me logo Genes that share phenotypes with ATP12A: view

Animal Models for ATP12A Gene

MGI Knock Outs for ATP12A:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP12A

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for ATP12A Gene

Localization for ATP12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP12A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP12A Gene COMPARTMENTS Subcellular localization image for ATP12A gene
Compartment Confidence
plasma membrane 4
lysosome 3
vacuole 3
chloroplast 2
cytosol 2
endoplasmic reticulum 2
endosome 2
extracellular 2
golgi apparatus 2
mitochondrion 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005889 hydrogen:potassium-exchanging ATPase complex TAS 8838794
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with ATP12A: view

Pathways & Interactions for ATP12A Gene

genes like me logo Genes that share pathways with ATP12A: view

Pathways by source for ATP12A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ATP12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006813 potassium ion transport --
GO:0006814 sodium ion transport --
GO:0006883 cellular sodium ion homeostasis IBA --
GO:0006885 regulation of pH IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ATP12A: view

No data available for SIGNOR curated interactions for ATP12A Gene

Drugs & Compounds for ATP12A Gene

(4) Drugs for ATP12A Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pantoprazole Approved Pharma 160
Adenosine triphosphate Approved Nutra 0
Ouabain Approved Pharma Na+/K+ ATPase inhibitor 0
Potassium Experimental Pharma 0

(4) Additional Compounds for ATP12A Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
hydrogen
  • Dihydrogen
  • Hydrogen gas
1333-74-0
genes like me logo Genes that share compounds with ATP12A: view

Transcripts for ATP12A Gene

mRNA/cDNA for ATP12A Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP12A Gene

ATPase, H+/K+ transporting, nongastric, alpha polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP12A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP12A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - -
SP2: -
SP3:

ExUns: 24b
SP1:
SP2:
SP3:

Relevant External Links for ATP12A Gene

GeneLoc Exon Structure for
ATP12A
ECgene alternative splicing isoforms for
ATP12A

Expression for ATP12A Gene

mRNA expression in normal human tissues for ATP12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP12A Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.7), Esophagus - Mucosa (x10.5), Skin - Sun Exposed (Lower leg) (x7.4), and Kidney - Cortex (x6.8).

Protein differential expression in normal tissues from HIPED for ATP12A Gene

This gene is overexpressed in Brain (18.4) and Nasal epithelium (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP12A Gene



SOURCE GeneReport for Unigene cluster for ATP12A Gene Hs.147111

mRNA Expression by UniProt/SwissProt for ATP12A Gene

P54707-AT12A_HUMAN
Tissue specificity: Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).
genes like me logo Genes that share expression patterns with ATP12A: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ATP12A Gene

Orthologs for ATP12A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP12A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP12A 35
  • 86.21 (n)
  • 87.6 (a)
ATP12A 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP12A 35
  • 88.09 (n)
  • 89.6 (a)
ATP12A 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp12a 35
  • 85.15 (n)
  • 86.96 (a)
Atp12a 16
Atp12a 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP12A 35
  • 99.46 (n)
  • 99.52 (a)
ATP12A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp12a 35
  • 84.68 (n)
  • 86.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ATP12A 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP12A 35
  • 76.51 (n)
  • 81.51 (a)
ATP12A 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP12A 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp12a 35
  • 64.81 (n)
  • 66.24 (a)
zebrafish
(Danio rerio)
Actinopterygii atp1a1a.3 36
  • 61 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Atpalpha 37
  • 63 (a)
CG17923 37
  • 54 (a)
CG3701 37
  • 29 (a)
Atpalpha 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C02E7.1 37
  • 36 (a)
eat-6 37
  • 59 (a)
Y105E8A.12 37
  • 31 (a)
eat-6 36
  • 60 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENA1 36
  • 26 (a)
ManyToMany
ENA2 36
  • 26 (a)
ManyToMany
ENA5 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for ATP12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP12A Gene

ENSEMBL:
Gene Tree for ATP12A (if available)
TreeFam:
Gene Tree for ATP12A (if available)

Paralogs for ATP12A Gene

Paralogs for ATP12A Gene

(6) SIMAP similar genes for ATP12A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ATP12A Gene

genes like me logo Genes that share paralogs with ATP12A: view

Variants for ATP12A Gene

Sequence variations from dbSNP and Humsavar for ATP12A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_020186 -

Structural Variations from Database of Genomic Variants (DGV) for ATP12A Gene

Variant ID Type Subtype PubMed ID
nsv899941 CNV Gain 21882294
nsv832568 CNV Gain 17160897
nsv471124 CNV Gain 18288195
nsv455843 CNV Gain 19166990
esv2751140 CNV Gain 17911159
nsv528064 CNV Loss 19592680
esv2499767 CNV Deletion 19546169
esv1956864 CNV Deletion 18987734
esv3452 CNV Deletion 18987735
esv1009925 CNV Deletion 20482838
esv2747149 CNV Deletion 23290073
esv8208 CNV Loss 19470904
esv2747150 CNV Deletion 23290073
esv2747151 CNV Deletion 23290073

Variation tolerance for ATP12A Gene

Residual Variation Intolerance Score: 50.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.79; 66.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP12A Gene

HapMap Linkage Disequilibrium report
ATP12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP12A Gene

Disorders for ATP12A Gene

MalaCards: The human disease database

(34) MalaCards diseases for ATP12A Gene - From: DISEASES

Disorder Aliases PubMed IDs
rumination disorder
  • psychogenic rumination
bladder calculus
  • urinary bladder calculi
chronic laryngitis
neonatal candidiasis
  • neonatal candida infection
squamous papillomatosis
- elite association

Relevant External Links for ATP12A

Genetic Association Database (GAD)
ATP12A
Human Genome Epidemiology (HuGE) Navigator
ATP12A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP12A
genes like me logo Genes that share disorders with ATP12A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP12A Gene

Publications for ATP12A Gene

  1. Genomic organization of the human ATP1AL1 gene encoding a ouabain- sensitive H,K-ATPase. (PMID: 8838794) Sverdlov V.E. … Modyanov N.N. (Genomics 1996) 2 23 67
  2. Phylogeny of penaeoid shrimps (Decapoda: Penaeoidea) inferred from nuclear protein-coding genes. (PMID: 19477284) Ma K.Y. … Chu K.H. (Mol. Phylogenet. Evol. 2009) 23 67
  3. Phylogeny of Decapoda using two nuclear protein-coding genes: origin and evolution of the Reptantia. (PMID: 18501643) Tsang L.M. … Chu K.H. (Mol. Phylogenet. Evol. 2008) 23 67
  4. An extracellular loop of the human non-gastric H,K-ATPase alpha-subunit is involved in apical plasma membrane polarization. (PMID: 16914892) Lerner M. … Reinhardt J. (Cell. Physiol. Biochem. 2006) 23 67
  5. Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast. (PMID: 15135233) Johansson M. … Powell T.L. (Placenta 2004) 23 67

Products for ATP12A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ATP12A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ATP12A
    • Block miRNA regulation of ATP12A using miScript Target Protectors

    Sources for ATP12A Gene

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