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Aliases for ATP11C Gene

Aliases for ATP11C Gene

  • ATPase, Class VI, Type 11C 2 3
  • ATPIG 3 4 6
  • ATPIQ 3 4 6
  • P4-ATPase Flippase Complex Alpha Subunit ATP11C 3 4
  • EC 3.6.3.1 4 63
  • Probable Phospholipid-Transporting ATPase IG 3
  • Phospholipid-Transporting ATPase IG 3
  • ATPase Class VI Type 11C 4
  • ATPase IQ 4
  • EC 3.6.3 63

External Ids for ATP11C Gene

Previous GeneCards Identifiers for ATP11C Gene

  • GC0XU990324
  • GC0XM137514
  • GC0XM138534
  • GC0XM138636
  • GC0XM138808
  • GC0XM128075

Summaries for ATP11C Gene

GeneCards Summary for ATP11C Gene

ATP11C (ATPase, Class VI, Type 11C) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion binding and phospholipid-translocating ATPase activity. An important paralog of this gene is ATP8B4.

UniProtKB/Swiss-Prot for ATP11C Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP11C Gene

Genomics for ATP11C Gene

Regulatory Elements for ATP11C Gene

Genomic Location for ATP11C Gene

Start:
139,726,346 bp from pter
End:
139,945,276 bp from pter
Size:
218,931 bases
Orientation:
Minus strand

Genomic View for ATP11C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP11C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP11C Gene

Proteins for ATP11C Gene

  • Protein details for ATP11C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB49-AT11C_HUMAN
    Recommended name:
    Phospholipid-transporting ATPase IG
    Protein Accession:
    Q8NB49
    Secondary Accessions:
    • Q5JT69
    • Q5JT70
    • Q5JT71
    • Q5JT72
    • Q5JT73
    • Q6ZND5
    • Q6ZU50
    • Q6ZUP7
    • Q70IJ9
    • Q70IK0
    • Q8WX24

    Protein attributes for ATP11C Gene

    Size:
    1132 amino acids
    Molecular mass:
    129477 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.
    SequenceCaution:
    • Sequence=BAC03692.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86172.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86377.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18440.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39713.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39714.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39716.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40418.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41444.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41445.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41446.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41447.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP11C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP11C Gene

Proteomics data for ATP11C Gene at MOPED

Post-translational modifications for ATP11C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP11C Gene

Domains for ATP11C Gene

Gene Families for ATP11C Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

Suggested Antigen Peptide Sequences for ATP11C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NB49

UniProtKB/Swiss-Prot:

AT11C_HUMAN :
  • Q8NB49
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP11C: view

Function for ATP11C Gene

Molecular function for ATP11C Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
UniProtKB/Swiss-Prot Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity).

Enzyme Numbers (IUBMB) for ATP11C Gene

Gene Ontology (GO) - Molecular Function for ATP11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity IBA --
GO:0005515 protein binding IPI 21914794
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATP11C: view
genes like me logo Genes that share phenotypes with ATP11C: view

miRNA for ATP11C Gene

miRTarBase miRNAs that target ATP11C

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP11C Gene

Localization for ATP11C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP11C Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP11C Gene COMPARTMENTS Subcellular localization image for ATP11C gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005783 endoplasmic reticulum IDA 21914794
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP11C: view

Pathways for ATP11C Gene

genes like me logo Genes that share pathways with ATP11C: view

Pathways by source for ATP11C Gene

Interacting Proteins for ATP11C Gene

Gene Ontology (GO) - Biological Process for ATP11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002329 pre-B cell differentiation IEA --
GO:0008152 metabolic process IEA --
GO:0015914 phospholipid transport --
GO:0034220 ion transmembrane transport TAS --
GO:0045332 phospholipid translocation NAS 21914794
genes like me logo Genes that share ontologies with ATP11C: view

Compounds for ATP11C Gene

(2605) HMDB Compounds for ATP11C Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
genes like me logo Genes that share compounds with ATP11C: view

Transcripts for ATP11C Gene

Unigene Clusters for ATP11C Gene

ATPase, class VI, type 11C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP11C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7: - -

Relevant External Links for ATP11C Gene

GeneLoc Exon Structure for
ATP11C
ECgene alternative splicing isoforms for
ATP11C

Expression for ATP11C Gene

mRNA expression in normal human tissues for ATP11C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP11C Gene

SOURCE GeneReport for Unigene cluster for ATP11C Gene Hs.88252

mRNA Expression by UniProt/SwissProt for ATP11C Gene

Q8NB49-AT11C_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with ATP11C: view

No data available for mRNA differential expression in normal tissues for ATP11C Gene

Orthologs for ATP11C Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP11C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP11C 35
  • 99.55 (n)
  • 99.45 (a)
ATP11C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP11C 35
  • 91.93 (n)
  • 93.81 (a)
ATP11C 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP11C 35
  • 93.88 (n)
  • 97 (a)
ATP11C 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp11c 35
  • 91.25 (n)
  • 94.82 (a)
Atp11c 16
Atp11c 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP11C 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Atp11c 35
  • 91.22 (n)
  • 95.62 (a)
chicken
(Gallus gallus)
Aves ATP11C 35
  • 76.96 (n)
  • 83.84 (a)
ATP11C 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP11C 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia atp11a-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498300 35
  • 73.31 (n)
  • 77.29 (a)
zebrafish
(Danio rerio)
Actinopterygii atp11c 35
  • 66.55 (n)
  • 72.16 (a)
atp11c 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4301 36
  • 30 (a)
ManyToMany
CG9981 36
  • 35 (a)
ManyToMany
Species with no ortholog for ATP11C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP11C Gene

ENSEMBL:
Gene Tree for ATP11C (if available)
TreeFam:
Gene Tree for ATP11C (if available)

Paralogs for ATP11C Gene

Paralogs for ATP11C Gene

Selected SIMAP similar genes for ATP11C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATP11C: view

Variants for ATP11C Gene

Sequence variations from dbSNP and Humsavar for ATP11C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1125214 -- 139,827,370(-) CCAAA(C/T)AACTA intron-variant
rs1268015 -- 139,743,516(+) TATTA(C/T)AAAAA intron-variant
rs1338059 -- 139,821,059(-) ATATA(G/T)TATGT intron-variant
rs1338060 -- 139,839,934(+) GCATA(A/G)AATAC intron-variant
rs1338061 -- 139,845,962(+) TAGAG(A/G)TCGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP11C Gene

Variant ID Type Subtype PubMed ID
nsv7116 CNV Loss 18451855

Relevant External Links for ATP11C Gene

HapMap Linkage Disequilibrium report
ATP11C
Locus Specific Mutation Databases (LSDB)
ATP11C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP11C Gene

Disorders for ATP11C Gene

No disorders were found for ATP11C Gene.

No data available for UniProtKB/Swiss-Prot for ATP11C Gene

Publications for ATP11C Gene

  1. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PMID: 21914794) Takatsu H. … Shin H.W. (J. Biol. Chem. 2011) 3 4
  4. X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase. (PMID: 15533723) Andrew-Nesbit M. … Thakker R.V. (Genomics 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for ATP11C Gene

Sources for ATP11C Gene

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