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ATP11C Gene

protein-coding   GIFtS: 53
GCID: GC0XM138808

ATPase, Class VI, Type 11C

(Previous names: ATPase, Class VI, type 11C)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATPase, Class VI, Type 11C1 2     Probable Phospholipid-Transporting ATPase IG2
ATPIG2 3 5     ATPase Class VI Type 11C3
ATPIQ2 3 5     ATPase IQ3
EC 3.6.3.13 8     EC 3.6.38
Phospholipid-Transporting ATPase IG2     

External Ids:    HGNC: 135541   Entrez Gene: 2864102   Ensembl: ENSG000001019747   OMIM: 3005165   UniProtKB: Q8NB493   

Export aliases for ATP11C gene to outside databases

Previous GC identifers: GC0XU990324 GC0XM137514 GC0XM138534 GC0XM138636 GC0XM128075


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATP11C Gene:
ATP11C (ATPase, class VI, type 11C) is a protein-coding gene. GO annotations related to this gene include phospholipid-translocating ATPase activity and magnesium ion binding. An important paralog of this gene is ATP11A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP11C gene promoter:
         Tal-1   Nkx2-2   Nkx2-5   E47   Evi-1   S8   Nkx6-1   GATA-6   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP11C promoter sequence
   Search Chromatin IP Primers for ATP11C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP11C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27.1   Ensembl cytogenetic band:  Xq27.1   HGNC cytogenetic band: Xq27.1

ATP11C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP11C gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM138808:  view genomic region     (about GC identifiers)

Start:
138,808,505 bp from pter      End:
139,027,435 bp from pter
Size:
218,931 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AT11C_HUMAN, Q8NB49 (See protein sequence)
Recommended Name: Probable phospholipid-transporting ATPase IG  
Size: 1132 amino acids; 129477 Da
Subunit: Interacts with TMEM30A, but not with TMEM30B
Sequence caution: Sequence=BAC03692.1; Type=Erroneous initiation; Sequence=BAC86172.1; Type=Erroneous initiation;
Sequence=BAC86377.1; Type=Erroneous initiation; Sequence=BAD18440.1; Type=Erroneous initiation;
Sequence=CAI39713.1; Type=Erroneous gene model prediction; Sequence=CAI39714.1; Type=Erroneous gene model
prediction; Sequence=CAI39716.1; Type=Erroneous gene model prediction; Sequence=CAI40418.1; Type=Erroneous gene
model prediction; Sequence=CAI41444.1; Type=Erroneous gene model prediction; Sequence=CAI41445.1; Type=Erroneous
gene model prediction; Sequence=CAI41446.1; Type=Erroneous gene model prediction; Sequence=CAI41447.1;
Type=Erroneous gene model prediction;
Secondary accessions: Q5JT69 Q5JT70 Q5JT71 Q5JT72 Q5JT73 Q6ZND5 Q6ZU50 Q6ZUP7 Q70IJ9 Q70IK0
Q8WX24
Alternative splicing: 4 isoforms:  Q8NB49-1   Q8NB49-2   Q8NB49-3   Q8NB49-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP11C: NX_Q8NB49

Explore proteomics data for ATP11C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATP11C (Q8NB49) (see all 11)
     GNWTFGT  LFEQFRR  DKTGTLT  PQFLYQF 


    See ATP11C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001010986.1  NP_775965.2  

    ENSEMBL proteins: 
     ENSP00000359588   ENSP00000397923   ENSP00000332756   ENSP00000355165   ENSP00000391259  
     ENSP00000394573   ENSP00000359574   ENSP00000352715  
    Reactome Protein details: Q8NB49

    ATP11C Human Recombinant Protein Products:

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    Novus Biologicals ATP11C Protein
    Novus Biologicals ATP11C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATP11C

     
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    Search for Antibodies for ATP11C at Abcam
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    ThermoFisher Antibody for ATP11C
    LSBio Antibodies in human, mouse, rat for ATP11C

    ATP11C Assay Products:

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    Cloud-Clone Corp. ELISAs for ATP11C
    Cloud-Clone Corp. CLIAs for ATP11C
    Search eBioscience for ELISAs for ATP11C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PATP: ATPases / P-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: ATP11C
    Phospholipid-transporting ATPase

    Selected InterPro protein domains (see all 6):
     IPR008250 ATPase_P-typ_transduc_dom_A
     IPR023214 HAD-like_dom
     IPR006539 ATPase_P-typ_Plipid-transp
     IPR001757 Cation_transp_P_typ_ATPase
     IPR018303 ATPase_P-typ_P_site

    Graphical View of Domain Structure for InterPro Entry Q8NB49

    ProtoNet protein and cluster: Q8NB49

    1 Blocks protein domain: IPB001757 ATPase

    UniProtKB/Swiss-Prot: AT11C_HUMAN, Q8NB49
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily


    Find genes that share domains with ATP11C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT11C_HUMAN, Q8NB49
    Catalytic activity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)

         Enzyme Numbers (IUBMB): EC 3.6.3.11 2 EC 3.6.32

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0000287magnesium ion binding IEA--
    GO:0004012phospholipid-translocating ATPase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ATP11C           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Atp11c):
     hematopoietic system  homeostasis/metabolism  immune system  normal  tumorigenesis 

    Find genes that share phenotypes with ATP11C           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATP11C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATP11C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATP11C

    miRNA
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    miRTarBase miRNAs that target ATP11C:
    hsa-mir-652-3p (MIRT039505), hsa-mir-9-5p (MIRT021452), hsa-mir-210-3p (MIRT003182)

    Block miRNA regulation of human, mouse, rat ATP11C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATP11C (see all 43):
    hsa-miR-429 hsa-miR-507 hsa-miR-9 hsa-miR-23a hsa-miR-200b hsa-miR-181b hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidATP11C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ATP11C

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): ATP11C (NM_173694)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP11C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP11C

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP11C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AT11C_HUMAN, Q8NB49: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Efficient
    exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in
    the presence of TMEM30B
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ATP11C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATP11C About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Ion transport by P-type ATPases
    Ion transport by P-type ATPases


    Find genes that share SuperPaths with ATP11C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ATP11C
        Ion transport by P-type ATPases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATP11C
    Interactions:

        Search GeneGlobe Interaction Network for ATP11C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ATP11C (ENSP000003327564) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    ATP5DENSP000002153754STRING: ENSP00000215375
    TMEM30BENSP000003479304STRING: ENSP00000347930
    MON2ENSP000003772524STRING: ENSP00000377252
    GBF1ENSP000003590004STRING: ENSP00000359000
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0015914phospholipid transport ----
    GO:0034220ion transmembrane transport TAS--
    GO:0045332phospholipid translocation NAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with ATP11C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATP11C (AT11C)

    Selected HMDB Compounds for ATP11C (see all 2605)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATP11C gene (2 alternative transcripts): 
    NM_001010986.2  NM_173694.4  

    Unigene Cluster for ATP11C:

    ATPase, class VI, type 11C
    Hs.88252  [show with all ESTs]
    Unigene Representative Sequence: NM_173694
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370557 ENST00000433868 ENST00000327569(uc004fay.3 uc004faz.3)
    ENST00000361648(uc004fax.3 uc004fba.3) ENST00000450801 ENST00000460773
    ENST00000471746 ENST00000422228 ENST00000485626 ENST00000370543 ENST00000359686

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ATP11C (see all 43):
    hsa-miR-429 hsa-miR-507 hsa-miR-9 hsa-miR-23a hsa-miR-200b hsa-miR-181b hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidATP11C 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ATP11C (NM_173694)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP11C
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      QuantiFast Probe-based Assays in human, mouse, rat ATP11C

    Additional mRNA sequence: 

    AJ580093.1 AJ580094.1 AK091552.1 AK093835.1 AK125474.1 AK131262.1 BC132728.1 BC132730.1 
    BX648320.1 BX648981.1 D16467.1 

    9 DOTS entries:

    DT.70101598  DT.97833893  DT.40284797  DT.100725310  DT.100685872  DT.70103245  DT.91696872  DT.92058622 
    DT.91670631 

    Selected AceView cDNA sequences (see all 87):

    AA827105 AK131262 BQ722735 AW160525 NM_173694 AJ580093 CA448156 AI762074 
    CA495286 BM053049 AJ580094 AA906534 CD643015 BM904860 AW162137 AK091552 
    AX747055 AA829385 AI371849 AI251931 BI871210 AI652796 AI284141 BX956266 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATP11C (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^
    SP1:                                            -                                                                                                               
    SP2:                                            -                                                                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
    SP1:                                      -                 -     -                     
    SP2:                                      -                 -     -     -               
    SP3:                                      -                 -                           
    SP4:                                      -                       -     -               
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ATP11C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ATP11C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ATP11C Expression
    About this image


    ATP11C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
    ATP11C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATP11C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.88252

    UniProtKB/Swiss-Prot: AT11C_HUMAN, Q8NB49
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATP11C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp11c1 , 5 ATPase, class VI, type 11C1, 5 91.25(n)1
    94.82(a)1
      X (33.50 cM)5
    3209401  NM_001037863.11  NP_001032952.11 
     602232905 
    chicken
    (Gallus gallus)
    Aves ATP11C1 ATPase, class VI, type 11C 76.96(n)
    83.84(a)
      422254  XM_004940686.1  XP_004940743.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATP11C6
    ATPase, class VI, type 11C
    65(a)
    1 ↔ 1
    GL343842.1(116438-187807)
    African clawed frog
    (Xenopus laevis)
    Amphibia atp11a-prov2 ATPase, Class VI, type 11A 76.45(n)    BC053328.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570433712   -- 76.54(n)    57043371 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99816
    CG43016
    --
    35(a)
    30(a)
    many ↔ many
    many ↔ many
    X(16293815-16299155)
    X(16299728-16308436)


    ENSEMBL Gene Tree for ATP11C (if available)
    TreeFam Gene Tree for ATP11C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATP11C gene
    ATP11A2  ATP8B12  ATP11B2  ATP8A12  ATP8B42  ATP8A22  ATP8B22  ATP8B32  
    11 SIMAP similar genes for ATP11C using alignment to 3 protein entries:     AT11C_HUMAN (see all proteins):
    ATP11A    DKFZp434P0831    ATP11B    DKFZp779H1459    ATP8B4    ATP8A1
    ATP8B1    ATP8B2    ATP8A2    ATP8B3    ATP9A

    Find genes that share paralogs with ATP11C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATP11C (see all 1304)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365024
    A colorectal cancer sample4--see VAR_0365022 Q P mis40--------
    VAR_0365014
    A colorectal cancer sample4--see VAR_0365012 T I mis40--------
    rs1925188461,2
    --138765492(+) ACAAAA/GTAGAC 2 -- int10--------
    rs1832570561,2
    --138765501(+) ACTTTC/TAATAT 2 -- int10--------
    rs21497821,2
    C,F,H--138765513(+) TATTTG/ACTGAT 2 -- int118Minor allele frequency- A:0.03NA EA NS WA CSA 1345
    rs1887195621,2
    --138765591(+) CCTCCC/TCAAAT 2 -- int10--------
    rs1484320951,2
    --138765658(+) AATTGC/TGCAGG 2 -- int10--------
    rs1926065961,2
    --138766000(+) AAATTC/TCATCA 2 -- ut310--------
    rs1425396771,2
    --138766207(+) TTTCCC/TTTTCT 2 -- ut310--------
    rs1464389921,2
    C--138766236(+) TTACAC/TTGAGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ATP11C (138808505 - 139027435 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ATP11C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7116CNV Loss18451855

    Locus Specific Mutation Databases (LSDB): ATP11C

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP11C
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP11C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300516    OMIM disorders: --


    Find genes that share disorders with ATP11C           About GenesLikeMe


    Export disorders for ATP11C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATP11C gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ATP11C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PubMed id 21914794)1, 2 Takatsu H.... Shin H.W. (J. Biol. Chem. 2011)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase. (PubMed id 15533723)1, 2 Andrew-Nesbit M....Thakker R.V. (Genomics 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Differential expression of putative transbilayer amphipath transporters. (PubMed id 11015572)1, 3 Halleck M.S.... Schlegel R.A. (Physiol. Genomics 1999)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 286410 HGNC: 13554 AceView: ATP11C Ensembl:ENSG00000101974 euGenes: HUgn286410
    ECgene: ATP11C H-InvDB: ATP11C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATP11C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATP11C gene:
    Search GeneIP for patents involving ATP11C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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