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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATP11C Gene

protein-coding GIFtS: 52
GCID: GC0XM138808

ATPase, class VI, type 11C

(Previous names: ATPase, Class VI, type 11C )

Explore 1 disease affiliated with
ATP11C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ATPase, Class VI, Type 11C¹ ²		Probable Phospholipid-Transporting ATPase IG²
ATPIG¹ ² ³		ATPase Class VI Type 11C³
ATPIQ¹ ² ³		ATPase IQ³
EC 3.6.3.1³ ⁸		EC 3.6.3⁸
Phospholipid-Transporting ATPase IG²

External Ids:	HGNC: 13554¹	Entrez Gene: 286410²	Ensembl: ENSG00000101974⁷	OMIM: 300516⁵	UniProtKB: Q8NB49³

Export aliases for ATP11C gene to outside databases

Previous GC identifers: GC0XU990324 GC0XM137514 GC0XM138534 GC0XM138636 GC0XM128075

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011786.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATP11C gene promoter:
Tal-1 Nkx2-2 Nkx2-5 E47 Evi-1 S8 Nkx6-1 GATA-6 FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATP11C promoter sequence

Search SABiosciences Chromatin IP Primers for ATP11C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP11C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27.1 Ensembl cytogenetic band: Xq27.1 HGNC cytogenetic band: Xq27.1

ATP11C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP11C gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM138808: view genomic region (about GC identifiers)

Start:	138,808,505 bp from pter	End:	139,027,435 bp from pter
Size:	218,931 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AT11C_HUMAN, Q8NB49 (See protein sequence)

Recommended Name: Probable phospholipid-transporting ATPase IG

Size: 1132 amino acids; 129477 Da

Subunit: Interacts with TMEM30A, but not with TMEM30B

Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Efficient exit

from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the

presence of TMEM30B

Sequence caution: Sequence=BAC03692.1; Type=Erroneous initiation; Sequence=BAC86172.1; Type=Erroneous initiation;

Sequence=BAC86377.1; Type=Erroneous initiation; Sequence=BAD18440.1; Type=Erroneous initiation; Sequence=CAI39713.1;

Type=Erroneous gene model prediction; Sequence=CAI39714.1; Type=Erroneous gene model prediction; Sequence=CAI39716.1;

Type=Erroneous gene model prediction; Sequence=CAI40418.1; Type=Erroneous gene model prediction; Sequence=CAI41444.1;

Type=Erroneous gene model prediction; Sequence=CAI41445.1; Type=Erroneous gene model prediction; Sequence=CAI41446.1;

Type=Erroneous gene model prediction; Sequence=CAI41447.1; Type=Erroneous gene model prediction;

Secondary accessions: Q5JT69 Q5JT70 Q5JT71 Q5JT72 Q5JT73 Q6ZND5 Q6ZU50 Q6ZUP7 Q70IJ9 Q70IK0 Q8WX24

Alternative splicing: 4 isoforms: Q8NB49-1 Q8NB49-2 Q8NB49-3 Q8NB49-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP11C: NX_Q8NB49

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NB49

4/11 DME Specific Peptides for ATP11C (Q8NB49) (see all 11)

GNWTFGT

LFEQFRR

DKTGTLT

PQFLYQF

ATP11C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001010986.1 NP_775965.2

ENSEMBL proteins:

ENSP00000359588 ENSP00000355165 ENSP00000397923 ENSP00000332756 ENSP00000391259

ENSP00000394573 ENSP00000359574 ENSP00000352715

Reactome Protein details: Q8NB49
Human Recombinant Protein Products:

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	Novus Biologicals ATP11C Protein Novus Biologicals ATP11C Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ATP11C

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

ATP11C for ontologies About GeneDecksing

ATP11C Antibody Products:

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	Novus Biologicals ATP11C Antibodies
	Search for Antibodies for ATP11C at Abcam
	Uscn Antibodies for ATP11C
	ThermoFisher Antibody for ATP11C

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	Uscn ELISAs and CLIAs for ATP11C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATP11C for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR023306 ATPase_cation_domN

IPR023299 ATPase_P-typ_cyto_domN

IPR008250 ATPase_P-typ_transduc_dom_A

IPR023214 HAD-like_dom

IPR006539 ATPase_P-typ_Plipid-transp

Graphical View of Domain Structure for InterPro Entry Q8NB49

ProtoNet protein and cluster: Q8NB49

1 Blocks protein family: IPB001757 ATPase

UniProtKB/Swiss-Prot: AT11C_HUMAN, Q8NB49

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AT11C_HUMAN, Q8NB49

Catalytic activity: ATP + H(2)O + phospholipid(side 1) = ADP + phosphate + phospholipid(side 2)

Enzyme Numbers (IUBMB): EC 3.6.3.1¹ ² EC 3.6.3²

miRNA Products:		miRTarBase miRNAs that target ATP11C: hsa-mir-210 (MIRT003182)

		OriGene 3'-UTR Clone (see all 2): ATP11C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATP11C
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP11C (see all 43):
		hsa-miR-429 hsa-miR-507 hsa-miR-9 hsa-miR-23a hsa-miR-200b hsa-miR-181b hsa-miR-3163 hsa-miR-4324

		SwitchGear 3'UTR luciferase reporter plasmid: ATP11C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP11C (see all 3) OriGene siRNA: ATP11C
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ATP11C

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): ATP11C (NM_173694)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP11C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP11C

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ATP11C
		Search LifeMap BioReagents cell lines for ATP11C

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP11C

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004012	phospholipid-translocating ATPase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	IEA	--

ATP11C for ontologies About GeneDecksing

Animal Models:
6 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Atp11c):

cellular	hematopoietic system	homeostasis/metabolism	immune system	normal
tumorigenesis

ATP11C for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ion channel transport

Ion channel transport

1.00

Ion transport by P-type ATPases

0.32

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for ATP11C

	Transmembrane transport of small molecules
	Ion channel transport
	Ion transport by P-type ATPases

ATP11C for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ATP11C

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ATP11C (ENSP00000332756⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006812	cation transport	IEA	--
GO:0034220	ion transmembrane transport	TAS	--
GO:0045332	phospholipid translocation	NAS	--
GO:0055085	transmembrane transport	TAS	--

ATP11C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ATP11C

10/2605 HMDB Compounds for ATP11C (see all 2605) About this table

Compound	Synonyms	CAS #	PubMed Ids
PC(O-16:0/18:2(9Z,12Z))	1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)	88542-95-4	12486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)	--	12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)	103597-60-0	12486725
PE(P-16:0e/0:0)	2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e)	--	12486725
PE(P-16:0e/18:1(9Z))	2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine	--	12486725
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
PA(16:0/16:0)	Dipalmitoylphosphatidic acid (see all 25)	7091-44-3	--
PA(16:0/18:1(11Z))	PA(16:0/18:1n7) (see all 10)	--	--
PA(16:0/18:1(9Z))	PA(16:0/18:1n9) (see all 10)	--	--

Search CenterWatch for drugs/clinical trials and news about ATP11C / AT11C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATP11C gene (2 alternative transcripts):

NM_001010986.2 NM_173694.4

Unigene Cluster for ATP11C:

ATPase, class VI, type 11C

Hs.88252 [show with all ESTs]

Unigene Representative Sequence: NM_173694

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370557 ENST00000361648(uc004fax.3 uc004fba.3) ENST00000433868

ENST00000327569(uc004fay.3 uc004faz.3) ENST00000450801 ENST00000460773

ENST00000471746 ENST00000422228 ENST00000485626 ENST00000370543 ENST00000359686

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ATP11C Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATP11C
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP11C (see all 43):
		hsa-miR-429 hsa-miR-507 hsa-miR-9 hsa-miR-23a hsa-miR-200b hsa-miR-181b hsa-miR-3163 hsa-miR-4324

		SwitchGear 3'UTR luciferase reporter plasmid: ATP11C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): ATP11C (NM_173694)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP11C

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP11C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP11C

Additional cDNA sequence:

AJ580093.1 AJ580094.1 AK091552.1 AK093835.1 AK125474.1 AK131262.1 BC132728.1 BC132730.1

BX648320.1 BX648981.1 D16467.1

9 DOTS entries:

DT.70101598 DT.97833893 DT.40284797 DT.100725310 DT.100685872 DT.70103245 DT.91696872 DT.92058622

DT.91670631

24/87 AceView cDNA sequences (see all 87):

AX747055 AW162137 BM904860 CD643015 AK091552 BM053049 AA827105 AA906534

CA495286 AK131262 NM_173694 AA829385 AI371849 CA448156 AI762074 BQ722735

AJ580093 AW160525 AJ580094 D16467 C02380 AI637740 AA258567 BM972713

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ATP11C (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^	21a	·	21b	^
SP1:															-
SP2:															-
SP3:
SP4:
SP5:

ExUns:	22	^	23	^	24	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30	^	31	^	32	^	33a	·	33b
SP1:													-						-		-
SP2:													-						-		-		-
SP3:													-						-
SP4:													-								-		-
SP5:

ECgene alternative splicing isoforms for ATP11C

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATP11C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ATP11C expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatid

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ATP11C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATP11C

SOURCE GeneReport for Unigene cluster: Hs.88252

UniProtKB/Swiss-Prot: AT11C_HUMAN, Q8NB49

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for ATP11C

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP11C Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP11C

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP11C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP11C gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ATP11C¹	ATPase, class VI, type 11C	76.91(n) 83.54(a)		422254 XM_420240.3 XP_420240.3
lizard (Anolis carolinensis)	Reptilia	ATP11C⁶	--	66(a)	1 ↔ 1	GL343842.1(116438-182731)
African clawed frog (Xenopus laevis)	Amphibia	atp11a-prov²	ATPase, Class VI, type 11A	76.45(n)		BC053328.1
zebrafish (Danio rerio)	Actinopterygii	57043371²	--	76.54(n)		57043371
fruit fly (Drosophila melanogaster)	Insecta	CG9981⁶ CG4301⁶	--	34(a) 30(a)	many ↔ many many ↔ many	X(16293815-16299155) X(16299728-16308436)
rice (Oryza sativa)	Liliopsida	--	phospholipid-transporting ATPase 2, putative, expr...	22(a)	possible ortholog	9(1611177-1614358)

ENSEMBL Gene Tree for ATP11C (if available)
TreeFam Gene Tree for ATP11C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ATP11C gene

ATP11A² ATP8B1² ATP11B² ATP8A1² ATP8B4² ATP8A2² ATP8B2² ATP8B3²

11 SIMAP similar genes for ATP11C using alignment to 3 protein entries: AT11C_HUMAN (see all proteins):

ATP11A DKFZp434P0831 ATP11B DKFZp779H1459 ATP8B4 ATP8A1

ATP8B1 ATP8B2 ATP8A2 ATP8B3 ATP9A

ATP11C for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192518846^1,2		--	138808237(+)	`ACAAAA/GTAGAC`	2	--	int¹		0	--	--	--	--
rs183257056^1,2		--	138808246(+)	`ACTTTC/TAATAT`	2	--	int¹		0	--	--	--	--
rs2149782^1,2	C,F,H,	--	138808258(+)	`TATTTG/ACTGAT`	2	--	int¹		18		NA EA NS WA CSA	1345
rs188719562^1,2		--	138808336(+)	`CCTCCC/TCAAAT`	2	--	int¹		0	--	--	--	--
rs148432095^1,2		--	138808403(+)	`AATTGC/TGCAGG`	2	--	int¹		0	--	--	--	--
rs192606596^1,2		--	138808745(+)	`AAATTC/TCATCA`	2	--	ut3¹		0	--	--	--	--
rs142539677^1,2		--	138808952(+)	`TTTCCC/TTTTCT`	2	--	ut3¹		0	--	--	--	--
rs146438992^1,2		--	138808981(+)	`TTACAC/TTGAGT`	2	--	ut3¹		0	--	--	--	--
rs2805901^1,2	C,F,O,A,H,	--	138809002(+)	`CTGCAT/CGGTCT`	2	--	ut3¹ ese³		20		NS EA NA WA	2228
rs144918632^1,2		--	138809169(+)	`AATGTA/GTAGCT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ATP11C (138808505 - 139027435 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATP11C: --
Locus Specific Mutation Databases (LSDB): ATP11C

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ATP11C for disorders           About GeneDecksing

OMIM gene information: 300516    OMIM disorders: --

1 disease for ATP11C:    About MalaCards

hypoparathyroidism

Export disorders for ATP11C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ATP11C gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with ATP11C)

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The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase. (PubMed id 15533723)^{1, 2} Andrew-Nesbit M....Thakker R.V. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Differential expression of putative transbilayer amphipath transporters. (PubMed id 11015572)^{1, 3} Halleck M.S.... Schlegel R.A. (1999)
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PubMed id 21914794)² Takatsu H.... Shin H.W. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 286410	HGNC: 13554	AceView: ATP11C	Ensembl:ENSG00000101974	euGenes: HUgn286410
ECgene: ATP11C	H-InvDB: ATP11C

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ATP11C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ATP11C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ATP11C gene:
Search GeneIP for patents involving ATP11C

GeneCards and IP:
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ATPase, class VI, type 11C

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ATP11C Gene

ATPase, class VI, type 11C

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