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Aliases for ATP11C Gene

Aliases for ATP11C Gene

  • ATPase Phospholipid Transporting 11C 2 3 5
  • P4-ATPase Flippase Complex Alpha Subunit ATP11C 3 4
  • ATPase, Class VI, Type 11C 2 3
  • EC 3.6.3.1 4 61
  • ATPIG 3 4
  • ATPIQ 3 4
  • Probable Phospholipid-Transporting ATPase IG 3
  • Phospholipid-Transporting ATPase IG 3
  • ATPase Class VI Type 11C 4
  • ATPase IQ 4
  • EC 3.6.3 61

External Ids for ATP11C Gene

Previous GeneCards Identifiers for ATP11C Gene

  • GC0XU990324
  • GC0XM137514
  • GC0XM138534
  • GC0XM138636
  • GC0XM138808
  • GC0XM128075

Summaries for ATP11C Gene

GeneCards Summary for ATP11C Gene

ATP11C (ATPase Phospholipid Transporting 11C) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP11A.

UniProtKB/Swiss-Prot for ATP11C Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP11C Gene

Genomics for ATP11C Gene

Regulatory Elements for ATP11C Gene

Enhancers for ATP11C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG139972 0.5 ENCODE 12.7 -28.6 -28550 2.1 GATA3 JUND HLF HNF4A ATP11C CXorf66 LOC728660
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP11C on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP11C Gene

Chromosome:
X
Start:
139,726,346 bp from pter
End:
139,945,276 bp from pter
Size:
218,931 bases
Orientation:
Minus strand

Genomic View for ATP11C Gene

Genes around ATP11C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP11C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP11C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP11C Gene

Proteins for ATP11C Gene

  • Protein details for ATP11C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB49-AT11C_HUMAN
    Recommended name:
    Phospholipid-transporting ATPase IG
    Protein Accession:
    Q8NB49
    Secondary Accessions:
    • Q5JT69
    • Q5JT70
    • Q5JT71
    • Q5JT72
    • Q5JT73
    • Q6ZND5
    • Q6ZU50
    • Q6ZUP7
    • Q70IJ9
    • Q70IK0
    • Q8WX24

    Protein attributes for ATP11C Gene

    Size:
    1132 amino acids
    Molecular mass:
    129477 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.
    SequenceCaution:
    • Sequence=BAC03692.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86172.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86377.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18440.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39713.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39714.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39716.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40418.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41444.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41445.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41446.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41447.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP11C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP11C Gene

Selected DME Specific Peptides for ATP11C Gene

Q8NB49:
  • KSQKRSAVEKS
  • IGDGANDVSMI
  • WVLTGDK
  • DKTGTLT
  • LNEELGQV
  • TAVEDKLQ
  • GKEGRQA
  • LFEQFRR
  • PQFLYQF
  • GNWTFGT
  • DTPTSPVTSGLPLFFVITVTAIKQGYED

Post-translational modifications for ATP11C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ATP11C Gene

Gene Families for ATP11C Gene

Suggested Antigen Peptide Sequences for ATP11C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NB49

UniProtKB/Swiss-Prot:

AT11C_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP11C: view

Function for ATP11C Gene

Molecular function for ATP11C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
UniProtKB/Swiss-Prot Function:
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity).

Enzyme Numbers (IUBMB) for ATP11C Gene

Gene Ontology (GO) - Molecular Function for ATP11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity IEA,TAS --
GO:0005515 protein binding IPI 21914794
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ATP11C: view
genes like me logo Genes that share phenotypes with ATP11C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP11C Gene

Localization for ATP11C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP11C Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP11C gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
lysosome 5
endosome 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ATP11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005783 endoplasmic reticulum IEA,IDA 21914794
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATP11C: view

Pathways & Interactions for ATP11C Gene

genes like me logo Genes that share pathways with ATP11C: view

Pathways by source for ATP11C Gene

Gene Ontology (GO) - Biological Process for ATP11C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002329 pre-B cell differentiation IEA --
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0015914 phospholipid transport IEA --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with ATP11C: view

No data available for SIGNOR curated interactions for ATP11C Gene

Drugs & Compounds for ATP11C Gene

(2) Drugs for ATP11C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(401) Additional Compounds for ATP11C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
genes like me logo Genes that share compounds with ATP11C: view

Transcripts for ATP11C Gene

Unigene Clusters for ATP11C Gene

ATPase, class VI, type 11C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP11C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7: - -

Relevant External Links for ATP11C Gene

GeneLoc Exon Structure for
ATP11C
ECgene alternative splicing isoforms for
ATP11C

Expression for ATP11C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP11C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATP11C Gene

This gene is overexpressed in Serum (40.2) and Testis (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP11C Gene



NURSA nuclear receptor signaling pathways regulating expression of ATP11C Gene:

ATP11C

SOURCE GeneReport for Unigene cluster for ATP11C Gene:

Hs.88252

mRNA Expression by UniProt/SwissProt for ATP11C Gene:

Q8NB49-AT11C_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ATP11C Gene

  • Liver(4.4)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ATP11C: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP11C Gene

Orthologs for ATP11C Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP11C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP11C 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia ATP11C 34 35
  • 93.88 (n)
cow
(Bos Taurus)
Mammalia ATP11C 34 35
  • 91.93 (n)
mouse
(Mus musculus)
Mammalia Atp11c 35 16 34
  • 91.25 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp11c 34
  • 91.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ATP11C 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP11C 35 34
  • 76.96 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP11C 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498300 34
  • 73.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia atp11a-prov 34
zebrafish
(Danio rerio)
Actinopterygii atp11c 35 34
  • 66.55 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9981 35
  • 35 (a)
ManyToMany
CG4301 35
  • 30 (a)
ManyToMany
Species where no ortholog for ATP11C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP11C Gene

ENSEMBL:
Gene Tree for ATP11C (if available)
TreeFam:
Gene Tree for ATP11C (if available)

Paralogs for ATP11C Gene

(11) SIMAP similar genes for ATP11C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATP11C: view

Variants for ATP11C Gene

Sequence variations from dbSNP and Humsavar for ATP11C Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036501 A colorectal cancer sample
VAR_036502 A colorectal cancer sample
rs1000008980 -- 139,737,974(+) CAGGC(-/T)TGATA nc-transcript-variant, reference, frameshift-variant
rs1000029932 -- 139,873,087(+) AAAAT(G/T)TCTAT intron-variant
rs1000031068 -- 139,850,042(+) TTTTA(A/T)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP11C Gene

Variant ID Type Subtype PubMed ID
esv3574799 CNV loss 25503493
esv3577426 CNV gain 25503493
nsv7116 CNV deletion 18451855

Variation tolerance for ATP11C Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP11C Gene

Human Gene Mutation Database (HGMD)
ATP11C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP11C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP11C Gene

Disorders for ATP11C Gene

Relevant External Links for ATP11C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP11C

No disorders were found for ATP11C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP11C Gene

Publications for ATP11C Gene

  1. Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium. (PMID: 26567335) Segawa K. … Nagata S. (J. Biol. Chem. 2016) 2 3 64
  2. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PMID: 21914794) Takatsu H. … Shin H.W. (J. Biol. Chem. 2011) 3 4 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase. (PMID: 15533723) Andrew-Nesbit M. … Thakker R.V. (Genomics 2004) 3 4 64

Products for ATP11C Gene

Sources for ATP11C Gene

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