Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP11B Gene

Aliases for ATP11B Gene

  • ATPase, Class VI, Type 11B 2 3
  • ATPIR 3 4 6
  • P4-ATPase Flippase Complex Alpha Subunit ATP11B 3 4
  • EC 3.6.3.1 4 63
  • ATPase IR 3 4
  • ATPIF 3 4
  • Probable Phospholipid-Transporting ATPase IF 3
  • Truncated ATPase 11B Protein 3
  • ATPase Class VI Type 11B 4
  • KIAA0956 4
  • EC 3.6.3 63

External Ids for ATP11B Gene

Previous GeneCards Identifiers for ATP11B Gene

  • GC03P179338
  • GC03P183431
  • GC03P183979
  • GC03P183832
  • GC03P183993
  • GC03P182511
  • GC03P179916

Summaries for ATP11B Gene

Entrez Gene Summary for ATP11B Gene

  • P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]

GeneCards Summary for ATP11B Gene

ATP11B (ATPase, Class VI, Type 11B) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion binding and phospholipid-translocating ATPase activity. An important paralog of this gene is ATP8B4.

UniProtKB/Swiss-Prot for ATP11B Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.

Gene Wiki entry for ATP11B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP11B Gene

Genomics for ATP11B Gene

Regulatory Elements for ATP11B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP11B Gene

Start:
182,793,500 bp from pter
End:
182,921,635 bp from pter
Size:
128,136 bases
Orientation:
Plus strand

Genomic View for ATP11B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP11B Gene

Proteins for ATP11B Gene

  • Protein details for ATP11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G3-AT11B_HUMAN
    Recommended name:
    Probable phospholipid-transporting ATPase IF
    Protein Accession:
    Q9Y2G3
    Secondary Accessions:
    • Q96FN1
    • Q9UKK7

    Protein attributes for ATP11B Gene

    Size:
    1177 amino acids
    Molecular mass:
    134190 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.
    Miscellaneous:
    • Depletion of ATP11B by RNAi restores sensitivity of ovarian cancer cells to cisplatin
    SequenceCaution:
    • Sequence=AAH10630.1; Type=Frameshift; Positions=884; Evidence={ECO:0000305}; Sequence=AAH42180.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for ATP11B Gene

Proteomics data for ATP11B Gene at MOPED

Post-translational modifications for ATP11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP11B Gene

Domains for ATP11B Gene

Gene Families for ATP11B Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

Suggested Antigen Peptide Sequences for ATP11B Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2G3

UniProtKB/Swiss-Prot:

AT11B_HUMAN :
  • Q9Y2G3
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP11B: view

Function for ATP11B Gene

Molecular function for ATP11B Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
UniProtKB/Swiss-Prot Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.

Enzyme Numbers (IUBMB) for ATP11B Gene

Gene Ontology (GO) - Molecular Function for ATP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity TAS 11015572
GO:0005515 protein binding IPI 21914794
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATP11B: view

Phenotypes for ATP11B Gene

genes like me logo Genes that share phenotypes with ATP11B: view

Animal Model Products

CRISPR Products

miRNA for ATP11B Gene

miRTarBase miRNAs that target ATP11B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP11B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP11B Gene

Localization for ATP11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP11B Gene

Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, mainly located in recycling endosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP11B Gene COMPARTMENTS Subcellular localization image for ATP11B gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
nucleus 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ATP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane NAS 11790799
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IDA 21914794
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ATP11B: view

Pathways for ATP11B Gene

genes like me logo Genes that share pathways with ATP11B: view

Pathways by source for ATP11B Gene

Interacting Proteins for ATP11B Gene

Gene Ontology (GO) - Biological Process for ATP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport NAS 11790799
GO:0008152 metabolic process IEA --
GO:0015914 phospholipid transport --
GO:0015917 aminophospholipid transport TAS 11015572
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with ATP11B: view

Compounds for ATP11B Gene

(2605) HMDB Compounds for ATP11B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
genes like me logo Genes that share compounds with ATP11B: view

Transcripts for ATP11B Gene

Unigene Clusters for ATP11B Gene

ATPase, class VI, type 11B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP11B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATP11B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP11B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^ 17
SP1:
SP2:
SP3: -
SP4:
SP5: - - -

Relevant External Links for ATP11B Gene

GeneLoc Exon Structure for
ATP11B
ECgene alternative splicing isoforms for
ATP11B

Expression for ATP11B Gene

mRNA expression in normal human tissues for ATP11B Gene

mRNA differential expression in normal tissues according to GTEx for ATP11B Gene

This gene is overexpressed in Whole Blood (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATP11B Gene

SOURCE GeneReport for Unigene cluster for ATP11B Gene Hs.478429

genes like me logo Genes that share expressions with ATP11B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATP11B Gene

Orthologs for ATP11B Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP11B 35
  • 99.66 (n)
  • 99.87 (a)
ATP11B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP11B 35
  • 92.92 (n)
  • 93.71 (a)
ATP11B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP11B 35
  • 93.48 (n)
  • 95.82 (a)
ATP11B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp11b 35
  • 90.7 (n)
  • 93.53 (a)
Atp11b 16
Atp11b 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP11B 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP11B 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp11b 35
  • 87.16 (n)
  • 89.67 (a)
chicken
(Gallus gallus)
Aves ATP11B 35
  • 80.92 (n)
  • 85.78 (a)
ATP11B 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP11B 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp11b 35
  • 76.61 (n)
  • 81.87 (a)
zebrafish
(Danio rerio)
Actinopterygii atp11b 36
  • 81 (a)
OneToOne
si:dkey-211e20.10 35
  • 71.21 (n)
  • 80 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000390 35
  • 47.23 (n)
  • 45.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4301 35
  • 47.48 (n)
  • 44.51 (a)
CG4301 36
  • 33 (a)
ManyToMany
CG9981 36
  • 39 (a)
ManyToMany
CG4301 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea T24H7.5a 37
  • 38 (a)
T24H7.5b 37
  • 38 (a)
Species with no ortholog for ATP11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP11B Gene

ENSEMBL:
Gene Tree for ATP11B (if available)
TreeFam:
Gene Tree for ATP11B (if available)

Paralogs for ATP11B Gene

Paralogs for ATP11B Gene

genes like me logo Genes that share paralogs with ATP11B: view

Variants for ATP11B Gene

Sequence variations from dbSNP and Humsavar for ATP11B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9587 -- 182,921,333(+) AAAAC(A/G)CTATT utr-variant-3-prime
rs472878 -- 182,848,134(+) TCTTT(C/G)TTAAC intron-variant
rs477777 -- 182,873,625(+) ACAAT(C/T)ACCAA intron-variant
rs489002 -- 182,844,716(+) TACTA(C/T)AGTTT intron-variant
rs491817 -- 182,845,044(+) TTGTC(A/G)CCCAG intron-variant

Relevant External Links for ATP11B Gene

HapMap Linkage Disequilibrium report
ATP11B
Human Gene Mutation Database (HGMD)
ATP11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATP11B Gene

Disorders for ATP11B Gene

No disorders were found for ATP11B Gene.

No data available for UniProtKB/Swiss-Prot for ATP11B Gene

Publications for ATP11B Gene

  1. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4
  5. Reanalysis of ATP11B, a Type IV P-type ATPase. (PMID: 11790799) Halleck M.S. … Williamson P.L. (J. Biol. Chem. 2002) 3 4

Products for ATP11B Gene

Sources for ATP11B Gene

Back to Top

Content