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Aliases for ATP11B Gene

Aliases for ATP11B Gene

  • ATPase Phospholipid Transporting 11B (Putative) 2 3 5
  • P4-ATPase Flippase Complex Alpha Subunit ATP11B 3 4
  • ATPase, Class VI, Type 11B 2 3
  • EC 3.6.3.1 4 61
  • ATPase IR 3 4
  • ATPIF 3 4
  • ATPIR 3 4
  • Probable Phospholipid-Transporting ATPase IF 3
  • Truncated ATPase 11B Protein 3
  • ATPase Class VI Type 11B 4
  • KIAA0956 4
  • EC 3.6.3 61

External Ids for ATP11B Gene

Previous GeneCards Identifiers for ATP11B Gene

  • GC03P179338
  • GC03P183431
  • GC03P183979
  • GC03P183832
  • GC03P183993
  • GC03P182511
  • GC03P179916

Summaries for ATP11B Gene

Entrez Gene Summary for ATP11B Gene

  • P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]

GeneCards Summary for ATP11B Gene

ATP11B (ATPase Phospholipid Transporting 11B (Putative)) is a Protein Coding gene. Among its related pathways are Ion channel transport and Immune System. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP11A.

UniProtKB/Swiss-Prot for ATP11B Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.

Gene Wiki entry for ATP11B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP11B Gene

Genomics for ATP11B Gene

Regulatory Elements for ATP11B Gene

Enhancers for ATP11B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F182821 0.2 ENCODE 23.8 +28.1 28072 1.0 ATP11B LOC105374245 MCCC1 ENSG00000273261 EIF3EP4
GH03F182814 0.2 Ensembl 21.9 +21.4 21401 0.6 ZNF121 HLF ZMYM3 ATP11B LOC105374245 ENSG00000273261 EIF3EP4
GH03F183210 1.1 FANTOM5 Ensembl ENCODE 20 +418.8 418847 4.5 ELF3 CBX3 MLX ARID4B YBX1 DMAP1 ZNF48 RAD21 RARA YY1 B3GNT5 ATP11B RNA5SP151 KLHL6 LAMP3 MCF2L2 MCCC1 KLHL24 DCUN1D1 RNU3P4
GH03F182760 0.5 ENCODE 19.7 -32.5 -32501 1.7 HDAC1 PKNOX1 RFX1 RNF2 NR2F1 TAL1 ARID1B JUND NCOR1 GATA2 ATP11B LOC105374245 ENSG00000260377
GH03F182792 0.6 ENCODE 18 +1.2 1160 4.8 HDGF ATF1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 ATP11B MCCC1 EIF3EP4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ATP11B on UCSC Golden Path with GeneCards custom track

Promoters for ATP11B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001380945 700 3601 HDGF ATF1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2

Genomic Location for ATP11B Gene

Chromosome:
3
Start:
182,793,500 bp from pter
End:
182,921,635 bp from pter
Size:
128,136 bases
Orientation:
Plus strand

Genomic View for ATP11B Gene

Genes around ATP11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP11B Gene

Proteins for ATP11B Gene

  • Protein details for ATP11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G3-AT11B_HUMAN
    Recommended name:
    Probable phospholipid-transporting ATPase IF
    Protein Accession:
    Q9Y2G3
    Secondary Accessions:
    • Q96FN1
    • Q9UKK7

    Protein attributes for ATP11B Gene

    Size:
    1177 amino acids
    Molecular mass:
    134190 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.
    Miscellaneous:
    • Depletion of ATP11B by RNAi restores sensitivity of ovarian cancer cells to cisplatin.
    SequenceCaution:
    • Sequence=AAH10630.1; Type=Frameshift; Positions=884; Evidence={ECO:0000305}; Sequence=AAH42180.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for ATP11B Gene

Selected DME Specific Peptides for ATP11B Gene

Q9Y2G3:
  • KSQKRSAVEKS
  • NDVSMIQ
  • FPADLVLLSS
  • WVLTGDK
  • DGETNLK
  • DKTGTLT
  • LNEELGQV
  • LLGATAVED
  • GKEGRQA
  • LFEQFRR
  • PQFLYQF
  • GNWTFGT
  • DTPTSPVTSGLPLFFVITVTAIKQGYED

Post-translational modifications for ATP11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ATP11B Gene

Gene Families for ATP11B Gene

Suggested Antigen Peptide Sequences for ATP11B Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2G3

UniProtKB/Swiss-Prot:

AT11B_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP11B: view

Function for ATP11B Gene

Molecular function for ATP11B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
UniProtKB/Swiss-Prot Function:
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). Involved in regulation of sensitivity to cisplatin; may contribute to secretory vesicle transport of cisplatin from Golgi to plasma membrane.

Enzyme Numbers (IUBMB) for ATP11B Gene

Gene Ontology (GO) - Molecular Function for ATP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity IEA,TAS 11015572
GO:0005515 protein binding IPI 21914794
GO:0005524 ATP binding IEA --
GO:0015075 ion transmembrane transporter activity NAS 11790799
genes like me logo Genes that share ontologies with ATP11B: view
genes like me logo Genes that share phenotypes with ATP11B: view

Animal Model Products

miRNA for ATP11B Gene

miRTarBase miRNAs that target ATP11B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP11B Gene

Localization for ATP11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP11B Gene

Recycling endosome membrane; Multi-pass membrane protein. Early endosome. Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B (PubMed:21914794). In the presence of TMEM30A, mainly located in recycling endosomes (PubMed:21914794). {ECO:0000269 PubMed:21914794}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP11B Gene COMPARTMENTS Subcellular localization image for ATP11B gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
nucleus 5
plasma membrane 5
golgi apparatus 3
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ATP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane NAS 11790799
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IEA,IDA 21914794
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with ATP11B: view

Pathways & Interactions for ATP11B Gene

genes like me logo Genes that share pathways with ATP11B: view

Gene Ontology (GO) - Biological Process for ATP11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport NAS 11790799
GO:0006869 lipid transport IEA --
GO:0015914 phospholipid transport IEA --
GO:0015917 aminophospholipid transport TAS 11015572
genes like me logo Genes that share ontologies with ATP11B: view

No data available for SIGNOR curated interactions for ATP11B Gene

Drugs & Compounds for ATP11B Gene

(2) Drugs for ATP11B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(401) Additional Compounds for ATP11B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
genes like me logo Genes that share compounds with ATP11B: view

Transcripts for ATP11B Gene

Unigene Clusters for ATP11B Gene

ATPase, class VI, type 11B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP11B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^ 17
SP1:
SP2:
SP3: -
SP4:
SP5: - - -

Relevant External Links for ATP11B Gene

GeneLoc Exon Structure for
ATP11B
ECgene alternative splicing isoforms for
ATP11B

Expression for ATP11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATP11B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP11B Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for ATP11B Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.4) and Amniocyte (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATP11B Gene



NURSA nuclear receptor signaling pathways regulating expression of ATP11B Gene:

ATP11B

SOURCE GeneReport for Unigene cluster for ATP11B Gene:

Hs.478429
genes like me logo Genes that share expression patterns with ATP11B: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ATP11B Gene

Orthologs for ATP11B Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP11B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP11B 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia ATP11B 34 35
  • 93.48 (n)
cow
(Bos Taurus)
Mammalia ATP11B 34 35
  • 92.92 (n)
mouse
(Mus musculus)
Mammalia Atp11b 34 16 35
  • 90.7 (n)
oppossum
(Monodelphis domestica)
Mammalia ATP11B 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp11b 34
  • 87.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATP11B 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP11B 34 35
  • 80.92 (n)
lizard
(Anolis carolinensis)
Reptilia ATP11B 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp11b 34
  • 76.61 (n)
zebrafish
(Danio rerio)
Actinopterygii atp11b 35
  • 81 (a)
OneToOne
si:dkey-211e20.10 34
  • 71.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4301 36 34 35
  • 47.48 (n)
CG9981 35
  • 39 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000390 34
  • 47.23 (n)
worm
(Caenorhabditis elegans)
Secernentea T24H7.5a 36
  • 38 (a)
T24H7.5b 36
  • 38 (a)
Species where no ortholog for ATP11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP11B Gene

ENSEMBL:
Gene Tree for ATP11B (if available)
TreeFam:
Gene Tree for ATP11B (if available)

Paralogs for ATP11B Gene

genes like me logo Genes that share paralogs with ATP11B: view

Variants for ATP11B Gene

Sequence variations from dbSNP and Humsavar for ATP11B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10049141 -- 182,823,553(+) tgatg(C/T)cttca intron-variant
rs10049257 -- 182,823,476(+) tatat(A/C)tctgt intron-variant
rs10084752 -- 182,845,261(+) ctcag(C/G)ttccc intron-variant
rs10222374 -- 182,793,563(+) ggcgc(C/T)ggggc nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1027874 -- 182,915,939(-) AGAAA(A/C)CTGGA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATP11B Gene

Variant ID Type Subtype PubMed ID
dgv2649n106 CNV deletion 24896259
nsv482968 CNV gain 15286789

Variation tolerance for ATP11B Gene

Residual Variation Intolerance Score: 55.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP11B Gene

Human Gene Mutation Database (HGMD)
ATP11B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP11B Gene

Disorders for ATP11B Gene

Relevant External Links for ATP11B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP11B

No disorders were found for ATP11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP11B Gene

Publications for ATP11B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3 4 64
  3. ATP11B mediates platinum resistance in ovarian cancer. (PMID: 23585472) Moreno-Smith M. … Sood A.K. (J. Clin. Invest. 2013) 3 4 64
  4. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PMID: 21914794) Takatsu H. … Shin H.W. (J. Biol. Chem. 2011) 3 4 64
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64

Products for ATP11B Gene

Sources for ATP11B Gene

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