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Aliases for ATP11A Gene

Aliases for ATP11A Gene

  • ATPase, Class VI, Type 11A 2 3
  • ATPIH 3 4 6
  • ATPIS 3 4 6
  • P4-ATPase Flippase Complex Alpha Subunit ATP11A 3 4
  • Potential Phospholipid-Transporting ATPase IH 2 3
  • Phospholipid-Translocating ATPase 2 3
  • EC 3.6.3.1 4 63
  • Probable Phospholipid-Transporting ATPase IH 3
  • ATPase Class VI Type 11A 4
  • ATPase IS 4
  • KIAA1021 4
  • EC 3.6.3 63

External Ids for ATP11A Gene

Previous GeneCards Identifiers for ATP11A Gene

  • GC13P112090
  • GC13P107981
  • GC13P112526
  • GC13P111385
  • GC13P112487
  • GC13P112393
  • GC13P113344
  • GC13P093786

Summaries for ATP11A Gene

Entrez Gene Summary for ATP11A Gene

  • The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP11A Gene

ATP11A (ATPase, Class VI, Type 11A) is a Protein Coding gene. Diseases associated with ATP11A include pulmonary fibrosis, idiopathic. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion binding and phospholipid-translocating ATPase activity. An important paralog of this gene is ATP8B4.

UniProtKB/Swiss-Prot for ATP11A Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP11A Gene

Genomics for ATP11A Gene

Regulatory Elements for ATP11A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP11A Gene

Start:
112,690,048 bp from pter
End:
112,887,168 bp from pter
Size:
197,121 bases
Orientation:
Plus strand

Genomic View for ATP11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP11A Gene

Proteins for ATP11A Gene

  • Protein details for ATP11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98196-AT11A_HUMAN
    Recommended name:
    Probable phospholipid-transporting ATPase IH
    Protein Accession:
    P98196
    Secondary Accessions:
    • Q5VXT2

    Protein attributes for ATP11A Gene

    Size:
    1134 amino acids
    Molecular mass:
    129756 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.
    Miscellaneous:
    • Overexpression of ATP11A confers resistance to lonafarnib

neXtProt entry for ATP11A Gene

Proteomics data for ATP11A Gene at MOPED

Post-translational modifications for ATP11A Gene

  • Ubiquitination at Lys702
  • Modification sites at PhosphoSitePlus

Other Protein References for ATP11A Gene

Domains for ATP11A Gene

Gene Families for ATP11A Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P98196

UniProtKB/Swiss-Prot:

AT11A_HUMAN :
  • P98196
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP11A: view

Function for ATP11A Gene

Molecular function for ATP11A Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
UniProtKB/Swiss-Prot Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.

Enzyme Numbers (IUBMB) for ATP11A Gene

Gene Ontology (GO) - Molecular Function for ATP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity IBA --
GO:0005515 protein binding IPI 21914794
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATP11A: view

Phenotypes for ATP11A Gene

MGI mutant phenotypes for ATP11A:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ATP11A: view

Animal Model Products

CRISPR Products

miRNA for ATP11A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP11A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP11A Gene

Localization for ATP11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP11A Gene

Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP11A Gene COMPARTMENTS Subcellular localization image for ATP11A gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
plasma membrane 5
chloroplast 2
cytoskeleton 2
cytosol 2
extracellular 2
mitochondrion 2
vacuole 2
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IDA 21914794
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ATP11A: view

Pathways for ATP11A Gene

genes like me logo Genes that share pathways with ATP11A: view

Pathways by source for ATP11A Gene

Interacting Proteins for ATP11A Gene

Gene Ontology (GO) - Biological Process for ATP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0015914 phospholipid transport --
GO:0045332 phospholipid translocation NAS 21914794
GO:0098655 cation transmembrane transport --
genes like me logo Genes that share ontologies with ATP11A: view

Compounds for ATP11A Gene

(2605) HMDB Compounds for ATP11A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
genes like me logo Genes that share compounds with ATP11A: view

Transcripts for ATP11A Gene

Unigene Clusters for ATP11A Gene

ATPase, class VI, type 11A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP11A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATP11A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP11A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

ExUns: 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b · 30c
SP1: -
SP2:
SP3:
SP4: - - - -
SP5:
SP6: - - -

Relevant External Links for ATP11A Gene

GeneLoc Exon Structure for
ATP11A
ECgene alternative splicing isoforms for
ATP11A

Expression for ATP11A Gene

mRNA expression in normal human tissues for ATP11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ATP11A Gene

SOURCE GeneReport for Unigene cluster for ATP11A Gene Hs.29189

genes like me logo Genes that share expressions with ATP11A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATP11A Gene

Orthologs for ATP11A Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP11A 35
  • 99.27 (n)
  • 99.5 (a)
ATP11A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP11A 35
  • 84.68 (n)
  • 92.27 (a)
ATP11A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP11A 35
  • 85.37 (n)
  • 93.9 (a)
ATP11A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp11a 35
  • 83.35 (n)
  • 91.09 (a)
Atp11a 16
Atp11a 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP11A 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP11A 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp11a 35
  • 83.72 (n)
  • 91.37 (a)
chicken
(Gallus gallus)
Aves ATP11A 35
  • 76.76 (n)
  • 86.89 (a)
ATP11A 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP11A 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp11a 35
  • 75.12 (n)
  • 85.68 (a)
zebrafish
(Danio rerio)
Actinopterygii atp11a 35
  • 74.77 (n)
  • 82.4 (a)
atp11a 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4301 36
  • 32 (a)
ManyToMany
CG9981 36
  • 36 (a)
ManyToMany
CG9981 37
  • 36 (a)
CG4301 37
  • 38 (a)
Species with no ortholog for ATP11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP11A Gene

ENSEMBL:
Gene Tree for ATP11A (if available)
TreeFam:
Gene Tree for ATP11A (if available)

Paralogs for ATP11A Gene

Paralogs for ATP11A Gene

genes like me logo Genes that share paralogs with ATP11A: view

Variants for ATP11A Gene

Sequence variations from dbSNP and Humsavar for ATP11A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs99126 -- 112,705,022(-) ATGCC(C/G/T)GTTAT intron-variant
rs166864 -- 112,713,135(-) ccagg(C/T)gtgag intron-variant
rs166865 -- 112,730,565(+) TCCAC(A/G)GCGTG intron-variant
rs166866 -- 112,731,842(+) GTGCA(C/G)GTGAG intron-variant
rs176081 -- 112,768,783(+) GTGAC(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP11A Gene

Variant ID Type Subtype PubMed ID
nsv518792 CNV Loss 19592680
esv2472921 CNV Insertion 19546169
nsv513401 CNV Insertion 21212237
esv1690416 CNV Insertion 17803354
dgv596e1 CNV Complex 17122850
nsv428291 CNV Loss 18775914
esv2510072 CNV Insertion 19546169
esv2662347 CNV Deletion 23128226
esv1527034 CNV Deletion 17803354
esv2748171 CNV Deletion 23290073
esv1086325 CNV Deletion 17803354
esv2748172 CNV Deletion 23290073
esv2378148 CNV Deletion 18987734
esv2748173 CNV Deletion 23290073
esv1707874 CNV Deletion 17803354
esv2748175 CNV Deletion 23290073
esv2456017 CNV Deletion 19546169
nsv512340 CNV Loss 21212237
esv2099073 CNV Deletion 18987734
esv2748176 CNV Deletion 23290073
esv29563 CNV Gain+Loss 19812545
nsv511521 CNV Loss 21212237
esv2748177 CNV Deletion 23290073
esv2748178 CNV Deletion 23290073
nsv901039 CNV Loss 21882294
esv22913 CNV Gain+Loss 19812545
nsv821432 CNV Deletion 20802225
esv1774255 CNV Deletion 17803354
esv2748179 CNV Deletion 23290073
esv997044 CNV Deletion 20482838
esv2748180 CNV Deletion 23290073
esv1622900 CNV Deletion 17803354
esv2748181 CNV Deletion 23290073
esv1122094 CNV Insertion 17803354
esv1002642 CNV Deletion 20482838
nsv64365 CNV Loss 16902084
esv2748182 CNV Deletion 23290073
esv2748183 CNV Deletion 23290073
esv2748184 CNV Deletion 23290073
nsv64969 CNV Loss 16902084
nsv1192 CNV Insertion 18451855
nsv901040 CNV Loss 21882294
esv2656956 CNV Deletion 23128226
esv2466127 CNV Deletion 19546169
esv2748186 CNV Deletion 23290073
esv1761970 CNV Deletion 17803354
esv2748187 CNV Deletion 23290073
esv2748188 CNV Deletion 23290073
dgv274e201 CNV Deletion 23290073
esv2678860 CNV Deletion 23128226
dgv382e199 CNV Deletion 23128226
esv2741315 CNV Deletion 23290073
esv2748190 CNV Deletion 23290073
dgv275e201 CNV Deletion 23290073
esv2748191 CNV Deletion 23290073
esv2748192 CNV Deletion 23290073
esv2748193 CNV Deletion 23290073
esv2748194 CNV Deletion 23290073
esv2748195 CNV Deletion 23290073
esv2748197 CNV Deletion 23290073
esv2748198 CNV Deletion 23290073
esv28043 CNV Gain 19812545
esv2546115 CNV Deletion 19546169
esv2748199 CNV Deletion 23290073
nsv820556 CNV Deletion 20802225
esv3606 CNV Deletion 18987735
esv2748200 CNV Deletion 23290073
esv1002063 CNV Deletion 20482838
nsv64912 CNV Loss 16902084
esv2748201 CNV Deletion 23290073
esv2748202 CNV Deletion 23290073
esv1436593 CNV Insertion 17803354
nsv832723 CNV Loss 17160897
nsv524253 CNV Loss 19592680
nsv1193 CNV Insertion 18451855
esv28063 CNV Gain 19812545
esv1528241 CNV Insertion 17803354
esv2748203 CNV Deletion 23290073
esv1479750 CNV Deletion 17803354
nsv64453 CNV Loss 16902084
esv1045101 CNV Deletion 17803354
esv1664651 CNV Deletion 17803354
dgv276e201 CNV Deletion 23290073
essv1950 CNV CNV 17122850
esv270977 CNV Insertion 20981092
esv272428 CNV Insertion 20981092
esv1152919 CNV Insertion 17803354
nsv509518 CNV Insertion 20534489
esv26123 CNV Loss 19812545
nsv821077 CNV Duplication 20802225
esv1564397 CNV Insertion 17803354
nsv64496 CNV Loss 16902084
esv1397948 CNV Insertion 17803354
dgv1797n71 CNV Loss 21882294
nsv901042 CNV Loss 21882294
nsv9110 CNV Gain 18304495
esv2748204 CNV Deletion 23290073
esv2748205 CNV Deletion 23290073

Relevant External Links for ATP11A Gene

HapMap Linkage Disequilibrium report
ATP11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP11A Gene

Disorders for ATP11A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ATP11A Gene including...

Search for ATP11A Gene in MalaCards »

Relevant External Links for ATP11A

Genetic Association Database (GAD)
ATP11A
Human Genome Epidemiology (HuGE) Navigator
ATP11A
genes like me logo Genes that share disorders with ATP11A: view

No data available for UniProtKB/Swiss-Prot for ATP11A Gene

Publications for ATP11A Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  2. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PMID: 21914794) Takatsu H. … Shin H.W. (J. Biol. Chem. 2011) 3 4

Products for ATP11A Gene

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Sources for ATP11A Gene

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