Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATP11A Gene

Aliases for ATP11A Gene

  • ATPase Phospholipid Transporting 11A 2 3
  • ATPase, Class VI, Type 11A 2 3 5
  • P4-ATPase Flippase Complex Alpha Subunit ATP11A 3 4
  • Potential Phospholipid-Transporting ATPase IH 2 3
  • Phospholipid-Translocating ATPase 2 3
  • EC 3.6.3.1 4 63
  • ATPIH 3 4
  • ATPIS 3 4
  • ATPase Class VI Type 11A 4
  • ATPase IS 4
  • KIAA1021 4
  • EC 3.6.3 63

External Ids for ATP11A Gene

Previous GeneCards Identifiers for ATP11A Gene

  • GC13P112090
  • GC13P107981
  • GC13P112526
  • GC13P111385
  • GC13P112487
  • GC13P112393
  • GC13P113344
  • GC13P093786

Summaries for ATP11A Gene

Entrez Gene Summary for ATP11A Gene

  • The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP11A Gene

ATP11A (ATPase Phospholipid Transporting 11A) is a Protein Coding gene. Diseases associated with ATP11A include Pulmonary Fibrosis, Idiopathic and Cerebellar Ataxia, Mental Retardation And Dysequlibrium Syndrome. Among its related pathways are Ion channel transport and Cardiac conduction. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP10A.

UniProtKB/Swiss-Prot for ATP11A Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP11A Gene

Genomics for ATP11A Gene

Regulatory Elements for ATP11A Gene

Enhancers for ATP11A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATP11A on UCSC Golden Path with GeneCards custom track

Promoters for ATP11A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATP11A on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP11A Gene

Chromosome:
13
Start:
112,690,049 bp from pter
End:
112,887,168 bp from pter
Size:
197,120 bases
Orientation:
Plus strand

Genomic View for ATP11A Gene

Genes around ATP11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP11A Gene

Proteins for ATP11A Gene

  • Protein details for ATP11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98196-AT11A_HUMAN
    Recommended name:
    Probable phospholipid-transporting ATPase IH
    Protein Accession:
    P98196
    Secondary Accessions:
    • Q5VXT2

    Protein attributes for ATP11A Gene

    Size:
    1134 amino acids
    Molecular mass:
    129756 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.
    Miscellaneous:
    • Overexpression of ATP11A confers resistance to lonafarnib.

neXtProt entry for ATP11A Gene

Proteomics data for ATP11A Gene at MOPED

Post-translational modifications for ATP11A Gene

  • Ubiquitination at Lys 702
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for AT11A

Domains & Families for ATP11A Gene

Gene Families for ATP11A Gene

Graphical View of Domain Structure for InterPro Entry

P98196

UniProtKB/Swiss-Prot:

AT11A_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP11A: view

Function for ATP11A Gene

Molecular function for ATP11A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
UniProtKB/Swiss-Prot Function:
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.

Enzyme Numbers (IUBMB) for ATP11A Gene

Gene Ontology (GO) - Molecular Function for ATP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ATP11A: view
genes like me logo Genes that share phenotypes with ATP11A: view

Human Phenotype Ontology for ATP11A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ATP11A Gene

MGI Knock Outs for ATP11A:

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP11A

No data available for Transcription Factor Targets and HOMER Transcription for ATP11A Gene

Localization for ATP11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP11A Gene

Cell membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Endoplasmic reticulum. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP11A Gene COMPARTMENTS Subcellular localization image for ATP11A gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
chloroplast 2
cytoskeleton 2
cytosol 2
extracellular 2
golgi apparatus 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ATP11A: view

Pathways & Interactions for ATP11A Gene

genes like me logo Genes that share pathways with ATP11A: view

Pathways by source for ATP11A Gene

Interacting Proteins for ATP11A Gene

Gene Ontology (GO) - Biological Process for ATP11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045332 phospholipid translocation IEA,NAS 21914794
genes like me logo Genes that share ontologies with ATP11A: view

No data available for SIGNOR curated interactions for ATP11A Gene

Drugs & Compounds for ATP11A Gene

(1) Drugs for ATP11A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(402) Additional Compounds for ATP11A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
genes like me logo Genes that share compounds with ATP11A: view

Transcripts for ATP11A Gene

Unigene Clusters for ATP11A Gene

ATPase, class VI, type 11A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP11A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

ExUns: 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30a · 30b · 30c
SP1: -
SP2:
SP3:
SP4: - - - -
SP5:
SP6: - - -

Relevant External Links for ATP11A Gene

GeneLoc Exon Structure for
ATP11A
ECgene alternative splicing isoforms for
ATP11A

Expression for ATP11A Gene

mRNA expression in normal human tissues for ATP11A Gene

Protein differential expression in normal tissues from HIPED for ATP11A Gene

This gene is overexpressed in Serum (56.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ATP11A Gene



SOURCE GeneReport for Unigene cluster for ATP11A Gene Hs.29189

genes like me logo Genes that share expression patterns with ATP11A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ATP11A Gene

Orthologs for ATP11A Gene

This gene was present in the common ancestor of animals.

Orthologs for ATP11A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP11A 35
  • 84.68 (n)
  • 92.27 (a)
ATP11A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP11A 35
  • 85.37 (n)
  • 93.9 (a)
ATP11A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp11a 35
  • 83.35 (n)
  • 91.09 (a)
Atp11a 16
Atp11a 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP11A 35
  • 99.27 (n)
  • 99.5 (a)
ATP11A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp11a 35
  • 83.72 (n)
  • 91.37 (a)
oppossum
(Monodelphis domestica)
Mammalia ATP11A 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP11A 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP11A 35
  • 76.76 (n)
  • 86.89 (a)
ATP11A 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP11A 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp11a 35
  • 75.12 (n)
  • 85.68 (a)
zebrafish
(Danio rerio)
Actinopterygii atp11a 35
  • 74.77 (n)
  • 82.4 (a)
atp11a 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4301 37
  • 38 (a)
CG9981 37
  • 36 (a)
CG4301 36
  • 32 (a)
ManyToMany
CG9981 36
  • 36 (a)
ManyToMany
Species with no ortholog for ATP11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATP11A Gene

ENSEMBL:
Gene Tree for ATP11A (if available)
TreeFam:
Gene Tree for ATP11A (if available)

Paralogs for ATP11A Gene

genes like me logo Genes that share paralogs with ATP11A: view

Variants for ATP11A Gene

Sequence variations from dbSNP and Humsavar for ATP11A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs11616795 - 112,875,885(+) CCGAC(A/G)TCCTC reference, missense
rs368865 - 112,825,506(+) AATAC(A/C/G/T)TGTGG nc-transcript-variant, reference, missense
rs99126 -- 112,705,022(-) ATGCC(C/G/T)GTTAT intron-variant
rs166864 -- 112,713,135(-) ccagg(C/T)gtgag intron-variant
rs166865 -- 112,730,565(+) TCCAC(A/G)GCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP11A Gene

Variant ID Type Subtype PubMed ID
nsv518792 CNV Loss 19592680
esv2472921 CNV Insertion 19546169
nsv513401 CNV Insertion 21212237
esv1690416 CNV Insertion 17803354
dgv596e1 CNV Complex 17122850
nsv428291 CNV Loss 18775914
esv2510072 CNV Insertion 19546169
esv2662347 CNV Deletion 23128226
esv1527034 CNV Deletion 17803354
esv2748171 CNV Deletion 23290073
esv1086325 CNV Deletion 17803354
esv2748172 CNV Deletion 23290073
esv2378148 CNV Deletion 18987734
esv2748173 CNV Deletion 23290073
esv1707874 CNV Deletion 17803354
esv2748175 CNV Deletion 23290073
esv2456017 CNV Deletion 19546169
nsv512340 CNV Loss 21212237
esv2099073 CNV Deletion 18987734
esv2748176 CNV Deletion 23290073
esv29563 CNV Gain+Loss 19812545
nsv511521 CNV Loss 21212237
esv2748177 CNV Deletion 23290073
esv2748178 CNV Deletion 23290073
nsv901039 CNV Loss 21882294
esv22913 CNV Gain+Loss 19812545
nsv821432 CNV Deletion 20802225
esv1774255 CNV Deletion 17803354
esv2748179 CNV Deletion 23290073
esv997044 CNV Deletion 20482838
esv2748180 CNV Deletion 23290073
esv1622900 CNV Deletion 17803354
esv2748181 CNV Deletion 23290073
esv1122094 CNV Insertion 17803354
esv1002642 CNV Deletion 20482838
nsv64365 CNV Loss 16902084
esv2748182 CNV Deletion 23290073
esv2748183 CNV Deletion 23290073
esv2748184 CNV Deletion 23290073
nsv64969 CNV Loss 16902084
nsv1192 CNV Insertion 18451855
nsv901040 CNV Loss 21882294
esv2656956 CNV Deletion 23128226
esv2466127 CNV Deletion 19546169
esv2748186 CNV Deletion 23290073
esv1761970 CNV Deletion 17803354
esv2748187 CNV Deletion 23290073
esv2748188 CNV Deletion 23290073
dgv274e201 CNV Deletion 23290073
esv2678860 CNV Deletion 23128226
dgv382e199 CNV Deletion 23128226
esv2741315 CNV Deletion 23290073
esv2748190 CNV Deletion 23290073
dgv275e201 CNV Deletion 23290073
esv2748191 CNV Deletion 23290073
esv2748192 CNV Deletion 23290073
esv2748193 CNV Deletion 23290073
esv2748194 CNV Deletion 23290073
esv2748195 CNV Deletion 23290073
esv2748197 CNV Deletion 23290073
esv2748198 CNV Deletion 23290073
esv28043 CNV Gain 19812545
esv2546115 CNV Deletion 19546169
esv2748199 CNV Deletion 23290073
nsv820556 CNV Deletion 20802225
esv3606 CNV Deletion 18987735
esv2748200 CNV Deletion 23290073
esv1002063 CNV Deletion 20482838
nsv64912 CNV Loss 16902084
esv2748201 CNV Deletion 23290073
esv2748202 CNV Deletion 23290073
esv1436593 CNV Insertion 17803354
nsv832723 CNV Loss 17160897
nsv524253 CNV Loss 19592680
nsv1193 CNV Insertion 18451855
esv28063 CNV Gain 19812545
esv1528241 CNV Insertion 17803354
esv2748203 CNV Deletion 23290073
esv1479750 CNV Deletion 17803354
nsv64453 CNV Loss 16902084
esv1045101 CNV Deletion 17803354
esv1664651 CNV Deletion 17803354
dgv276e201 CNV Deletion 23290073
essv1950 CNV CNV 17122850
esv270977 CNV Insertion 20981092
esv272428 CNV Insertion 20981092
esv1152919 CNV Insertion 17803354
nsv509518 CNV Insertion 20534489
esv26123 CNV Loss 19812545
nsv821077 CNV Duplication 20802225
esv1564397 CNV Insertion 17803354
nsv64496 CNV Loss 16902084
esv1397948 CNV Insertion 17803354
dgv1797n71 CNV Loss 21882294
nsv901042 CNV Loss 21882294
nsv9110 CNV Gain 18304495
esv2748204 CNV Deletion 23290073
esv2748205 CNV Deletion 23290073

Variation tolerance for ATP11A Gene

Residual Variation Intolerance Score: 6.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATP11A Gene

Disorders for ATP11A Gene

MalaCards: The human disease database

(3) MalaCards diseases for ATP11A Gene - From: Orphanet and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ATP11A

Genetic Association Database (GAD)
ATP11A
Human Genome Epidemiology (HuGE) Navigator
ATP11A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP11A
genes like me logo Genes that share disorders with ATP11A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATP11A Gene

Publications for ATP11A Gene

  1. Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium. (PMID: 26567335) Segawa K. … Nagata S. (J. Biol. Chem. 2016) 2 3 67
  2. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. (PMID: 23583980) Fingerlin T.E. … Schwartz D.A. (Nat. Genet. 2013) 3
  5. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PMID: 21914794) Takatsu H. … Shin H.W. (J. Biol. Chem. 2011) 3

Products for ATP11A Gene

Sources for ATP11A Gene

Content