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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATP10D Gene

protein-coding   GIFtS: 57
GCID: GC04P047487

ATPase, Class V, Type 10D

(Previous names: ATPase, Class V, type 10D)
  Search for ATP10D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ATPase, Class V, Type 10D1 2     Type IV Aminophospholipid Transporting ATPase2
ATPVD2 3     KIAA14873
EC 3.6.3.13 8     ATPase Class V Type 10D3
Probable Phospholipid-Transporting ATPase VD2     EC 3.6.38

External Ids:    HGNC: 135491   Entrez Gene: 572052   Ensembl: ENSG000001452467   UniProtKB: Q9P2413   

Export aliases for ATP10D gene to outside databases

Previous GC identifers: GC04P047614 GC04P047847 GC04P047337 GC04P047402 GC04P047328 GC04P047182 GC04P046806


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ATP10D Gene: 
ATP10D (ATPase, class V, type 10D) is a protein-coding gene. Among its related super-pathways are Ion channel transport and SLC-mediated transmembrane transport. GO annotations related to this gene include phospholipid-translocating ATPase activity and magnesium ion binding. An important paralog of this gene is ATP8B1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006238.11  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATP10D gene promoter:
         TBP   AP-1   MIF-1   C/EBPalpha   GATA-1   MEF-2A   FOXJ2 (long isoform)   TFIID   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATP10D promoter sequence
   Search SABiosciences Chromatin IP Primers for ATP10D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP10D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p12

ATP10D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP10D gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P047487:  view genomic region     (about GC identifiers)

Start:
47,487,305 bp from pter      End:
47,595,503 bp from pter
Size:
108,199 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AT10D_HUMAN, Q9P241 (See protein sequence)
Recommended Name: Probable phospholipid-transporting ATPase VD  
Size: 1426 amino acids; 160274 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from
the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B
Sequence caution: Sequence=BAB55221.1; Type=Frameshift; Positions=748; Sequence=BAC11299.1; Type=Erroneous
initiation;
Secondary accessions: A2RRC8 D6REN2 Q8NC70 Q96SR3
Alternative splicing: 2 isoforms:  Q9P241-1   Q9P241-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP10D: NX_Q9P241

Explore proteomics data for ATP10D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P241

  • 4/21 DME Specific Peptides for ATP10D (Q9P241) (see all 21)
     LAIGDGA  WMLTGDK  NDVSMIQ  TLAIGDG 

    ATP10D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATP10D Protein Expression
    REFSEQ proteins: NP_065186.3  
    ENSEMBL proteins: 
     ENSP00000273859   ENSP00000420909   ENSP00000421536  
    Reactome Protein details: Q9P241
    Human Recombinant Protein Products for ATP10D: 
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    Cloud-Clone Corp. Proteins for ATP10D 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS12532265

    ATP10D for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PATP: ATPases / P-type

    IUPHAR Guide to PHARMACOLOGY protein family classification: ATP10D 
    Phospholipid-transporting ATPase

    5/6 InterPro protein domains (see all 6):
     IPR023299 ATPase_P-typ_cyto_domN
     IPR008250 ATPase_P-typ_transduc_dom_A
     IPR023214 HAD-like_dom
     IPR006539 ATPase_P-typ_Plipid-transp
     IPR001757 Cation_transp_P_typ_ATPase

    Graphical View of Domain Structure for InterPro Entry Q9P241

    ProtoNet protein and cluster: Q9P241

    1 Blocks protein domain: IPB001757 ATPase

    UniProtKB/Swiss-Prot: AT10D_HUMAN, Q9P241
    Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily


    ATP10D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AT10D_HUMAN, Q9P241
    Catalytic activity: ATP + H(2)O + phospholipid(side 1) = ADP + phosphate + phospholipid(side 2)

         Enzyme Numbers (IUBMB): EC 3.6.3.11 2 EC 3.6.32

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0000287magnesium ion binding NAS12532265
    GO:0004012phospholipid-translocating ATPase activity NAS12532265
    GO:0005515protein binding IPI--
    GO:0005524ATP binding NAS12532265
         
    ATP10D for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Atp10d (no phenotypes)

    ATP10D for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ATP10D 
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    miRNA
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    miRTarBase miRNAs that target ATP10D:
    hsa-mir-192 (MIRT004152)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATP10D
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP10D (see all 24):
    hsa-miR-125a-5p hsa-miR-4251 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-4263 hsa-miR-885-5p hsa-miR-3653 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidATP10D 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP10D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATP10D About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.49
    Ion transport by P-type ATPases0.32
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for ATP10D
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases



    ATP10D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATP10D

    5/12 Interacting proteins for ATP10D (Q9P2413) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARFGEF1Q9Y6D63I2D: score=4 
    ATP8A1Q9Y2Q03I2D: score=4 
    LARSQ9P2J53I2D: score=3 
    PAPD5Q8NDF83I2D: score=3 
    TMED2Q153633I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport NAS12532265
    GO:0015914phospholipid transport ----
    GO:0034220ion transmembrane transport TAS--
    GO:0045332phospholipid translocation NAS--
    GO:0055085transmembrane transport TAS--

    ATP10D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATP10D (AT10D)

    10/2605 HMDB Compounds for ATP10D (see all 2605)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----

    Search CenterWatch for drugs/clinical trials and news about ATP10D / AT10D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATP10D gene: 
    NM_020453.3  

    Unigene Cluster for ATP10D:

    ATPase, class V, type 10D
    Hs.437241  [show with all ESTs]
    Unigene Representative Sequence: AJ441078
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273859(uc003gxk.1 uc003gxl.1) ENST00000507889 ENST00000504445(uc003gxj.3)
    ENST00000503288 ENST00000505476 ENST00000512393 ENST00000505277
    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP10D (see all 24):
    hsa-miR-125a-5p hsa-miR-4251 hsa-miR-4328 hsa-miR-520d-5p hsa-miR-4263 hsa-miR-885-5p hsa-miR-3653 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidATP10D 3' UTR sequence
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    Additional mRNA sequence: 

    AB040920.1 AJ441078.1 AK027598.1 AK074930.1 BC057839.1 BC108723.1 BC131535.1 

    7 DOTS entries:

    DT.99987132  DT.65287392  DT.92059118  DT.100644720  DT.75113444  DT.75126966  DT.92012890 

    24/109 AceView cDNA sequences (see all 109):

    AI262028 AA805562 BX499392 AI262031 BF514734 Z38884 BQ771580 AI982946 
    BX472066 AA257051 AJ441078 BX095565 AK074930 NM_020453 BC057839 AW614203 
    AL601625 AW292265 BE549713 AL541190 AI560066 CA447151 Z42728 AI096657 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ATP10D    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                                                                -                                                                           
    SP2:                                                                                -           -     -                                                         
    SP3:                                                              -                                                                                             

    ExUns: 21 ^ 22 ^ 23a · 23b
    SP1:                        
    SP2:                        
    SP3:                        


    ECgene alternative splicing isoforms for ATP10D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATP10D expression in normal human tissues (normalized intensities)      ATP10D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCATATGCA
    ATP10D Expression
    About this image


    ATP10D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...

    See ATP10D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATP10D

    SOURCE GeneReport for Unigene cluster: Hs.437241

    UniProtKB/Swiss-Prot: AT10D_HUMAN, Q9P241
    Tissue specificity: Expressed in placenta and, to a lesser extent, in kidney

        SABiosciences Custom PCR Arrays for ATP10D
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP10D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATP10D gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atp10d5 ATPase, class V, type 10D   --   5 (38.44 cM) 72203329 
    chicken
    (Gallus gallus)
    Aves ATP10D1 ATPase, class V, type 10D 70.23(n)
    71.24(a)
      422768  XM_420722.3  XP_420722.3 
    lizard
    (Anolis carolinensis)
    Reptilia ATP10D6
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL343361.1(597928-656125)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.106032 Transcribed sequence with weak similarity to protein more 73.17(n)    BX775413.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atp10d1 ATPase, class V, type 10D 59.22(n)
    57.15(a)
      571658  NM_001145607.1  NP_001139079.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG184193
    CG332981
    calcium-transporting ATPase3
    CG332981
    47(a)3
    50.97(n)1
    45.1(a)1
      27689291  NM_001169448.11  NP_001162919.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W09D10.23
    tat-31
    ATPase3
    Protein TAT-31
    41(a)
    (best of 3)3
    48.95(n)1
    42.23(a)1
      III(10794590-10801091)3
    1764981  NM_066962.31  NP_499363.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DNF26
    DNF16
    Aminophospholipid translocase (flippase) that loca...
    Aminophospholipid translocase (flippase) that loca...
    25(a)
    25(a)
    1 ↔ many
    possible ortholog
    IV(631282-636120)
    V(512744-517459)
    rice
    (Oryza sativa)
    Liliopsida Os.154632 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.87(n)    AK063540.1 


    ENSEMBL Gene Tree for ATP10D (if available)
    TreeFam Gene Tree for ATP10D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATP10D gene
    ATP8B12  ATP10B2  ATP10A2  
    11 SIMAP similar genes for ATP10D using alignment to 3 protein entries:     AT10D_HUMAN (see all proteins):
    ATP10A    ATP10B    DKFZp779H1459    DKFZp434P0831    DKFZp686H2093    ATP8B4
    ATP8B3    ATP8B1    ATP8A1    ATP8A2    ATP8B2

    ATP10D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2229 SNPs in ATP10D are shown (see all 2229)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1125655361,2
    Cuntested147593286(+) AAGTTC/TCTGTG 2 S F mis11Minor allele frequency- T:0.50CSA 2
    rs68441731,2
    C,F,A,H--47485458(+) ATTGAC/TAGAAA 1 -- us2k110Minor allele frequency- T:0.17NA WA CSA EA 373
    rs68442031,2
    C,F--47485513(+) GAGTAT/CTGatt 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs133280351,2
    C,F--47485526(+) TAAAAA/CTTTGA 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs1842121951,2
    --47485841(+) TTCTAC/GAGGAG 1 -- us2k10--------
    rs1871416991,2
    --47485871(+) CATAGC/TGCCAC 1 -- us2k10--------
    rs1928668661,2
    --47485894(+) TGGTTG/TAATTG 1 -- us2k10--------
    rs1845328101,2
    --47486270(+) AAGTTC/TTAGAG 1 -- us2k10--------
    rs754328451,2
    C,F--47486364(+) AGAAGC/TACGTT 1 -- us2k11Minor allele frequency- T:0.04NA 120
    rs790424191,2
    C,F--47486512(+) TCTTGT/CTGCAC 1 -- us2k11Minor allele frequency- C:0.12WA 118

    HapMap Linkage Disequilibrium report for ATP10D (47487305 - 47595503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for ATP10D (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2727527CNV Deletion23290073
    esv1010678CNV Deletion20482838
    esv2727528CNV Deletion23290073
    esv2296261CNV Deletion18987734
    esv1569407CNV Deletion17803354
    esv2727530CNV Deletion23290073
    nsv4327CNV Insertion18451855
    esv272974CNV Insertion20981092
    esv268385CNV Insertion20981092
    esv2588788CNV Insertion19546169


    Human Gene Mutation Database (HGMD): ATP10D
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ATP10D
    DNA2.0 Custom Variant and Variant Library Synthesis for ATP10D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ATP10D for disorders           About MalaCards

    ATP10D for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATP10D
    Human Genome Epidemiology (HuGE) Navigator: ATP10D (3 documents)

    Export disorders for ATP10D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATP10D gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ATP10D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a putative type IV aminophospholipid transporter P-type ATPase. (PubMed id 12532265)1, 2, 3, 9 Flamant S.... Besmond C. (2003)
    2. Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. Genetic determinants of circulating sphingolipid conc entrations in European populations. (PubMed id 19798445)1, 4 Hicks A.A....Campbell H. (2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PubMed id 21914794)2 Takatsu H.... Shin H.W. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57205 HGNC: 13549 AceView: ATP10D Ensembl:ENSG00000145246 euGenes: HUgn57205
    ECgene: ATP10D H-InvDB: ATP10D

    (According to HUGE)
    About This Section
    HUGE: KIAA1487

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATP10D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATP10D gene:
    Search GeneIP for patents involving ATP10D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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