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Aliases for ATP10D Gene

Aliases for ATP10D Gene

  • ATPase, Class V, Type 10D 2 3
  • P4-ATPase Flippase Complex Alpha Subunit ATP10D 3 4
  • EC 4 64
  • ATPVD 3 4
  • Type IV Aminophospholipid Transporting ATPase 3
  • Probable Phospholipid-Transporting ATPase VD 3
  • ATPase Class V Type 10D 4
  • KIAA1487 4
  • EC 3.6.3 64

External Ids for ATP10D Gene

Summaries for ATP10D Gene

GeneCards Summary for ATP10D Gene

ATP10D (ATPase, Class V, Type 10D) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion binding and phospholipid-translocating ATPase activity. An important paralog of this gene is ATP10A.

UniProtKB/Swiss-Prot for ATP10D Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP10D Gene

Genomics for ATP10D Gene

Genomic Location for ATP10D Gene

47,485,280 bp from pter
47,593,486 bp from pter
108,207 bases
Plus strand

Genomic View for ATP10D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP10D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP10D Gene

Regulatory Elements for ATP10D Gene

Proteins for ATP10D Gene

  • Protein details for ATP10D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable phospholipid-transporting ATPase VD
    Protein Accession:
    Secondary Accessions:
    • A2RRC8
    • D6REN2
    • Q8NC70
    • Q96SR3

    Protein attributes for ATP10D Gene

    1426 amino acids
    Molecular mass:
    160274 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.
    • Sequence=BAB55221.1; Type=Frameshift; Positions=748; Evidence={ECO:0000305}; Sequence=BAC11299.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP10D Gene


neXtProt entry for ATP10D Gene

Proteomics data for ATP10D Gene at MOPED

Post-translational modifications for ATP10D Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys942

Other Protein References for ATP10D Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ATP10D Gene

Gene Families for ATP10D Gene

  • PATP :ATPases / P-type


  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.:
    • Q9P241
genes like me logo Genes that share domains with ATP10D: view

Function for ATP10D Gene

Molecular function for ATP10D Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
UniProtKB/Swiss-Prot Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

Enzyme Numbers (IUBMB) for ATP10D Gene

Gene Ontology (GO) - Molecular Function for ATP10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding NAS 12532265
GO:0004012 phospholipid-translocating ATPase activity NAS 12532265
GO:0005515 protein binding IPI 21914794
GO:0005524 ATP binding NAS 12532265
genes like me logo Genes that share ontologies with ATP10D: view

miRNA for ATP10D Gene

miRTarBase miRNAs that target ATP10D

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP10D Gene

Localization for ATP10D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP10D Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.

Subcellular locations from

Jensen Localization Image for ATP10D Gene COMPARTMENTS Subcellular localization image for ATP10D gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytoskeleton 3
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for ATP10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IDA 21914794
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ATP10D: view

Pathways for ATP10D Gene

genes like me logo Genes that share pathways with ATP10D: view

Pathways by source for ATP10D Gene

Gene Ontology (GO) - Biological Process for ATP10D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport NAS 12532265
GO:0006886 intracellular protein transport IBA --
GO:0008152 metabolic process IEA --
GO:0015914 phospholipid transport --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with ATP10D: view

Compounds for ATP10D Gene

(2605) HMDB Compounds for ATP10D Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Dipalmitoylphosphatidic acid
  • PA(16:0/18:1n7)
Not Available
  • PA(16:0/18:1n9)
Not Available
genes like me logo Genes that share compounds with ATP10D: view

Transcripts for ATP10D Gene

Unigene Clusters for ATP10D Gene

ATPase, class V, type 10D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP10D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2: - - -
SP3: -

ExUns: 21 ^ 22 ^ 23a · 23b

Relevant External Links for ATP10D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATP10D Gene

mRNA expression in normal human tissues for ATP10D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP10D Gene

SOURCE GeneReport for Unigene cluster for ATP10D Gene Hs.437241

mRNA Expression by UniProt/SwissProt for ATP10D Gene

Tissue specificity: Expressed in placenta and, to a lesser extent, in kidney.
genes like me logo Genes that share expressions with ATP10D: view

Orthologs for ATP10D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP10D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATP10D 36
  • 99.46 (n)
  • 99.44 (a)
ATP10D 37
  • 99 (a)
(Bos Taurus)
Mammalia ATP10D 36
  • 87.93 (n)
  • 87.68 (a)
ATP10D 37
  • 86 (a)
(Canis familiaris)
Mammalia ATP10D 36
  • 85.96 (n)
  • 85.3 (a)
ATP10D 37
  • 85 (a)
(Mus musculus)
Mammalia Atp10d 16
(Monodelphis domestica)
Mammalia ATP10D 37
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ATP10D 37
  • 51 (a)
(Rattus norvegicus)
Mammalia Atp10d 36
  • 83.79 (n)
  • 84.19 (a)
(Gallus gallus)
Aves ATP10D 36
  • 69.79 (n)
  • 70.41 (a)
ATP10D 37
  • 66 (a)
(Anolis carolinensis)
Reptilia ATP10D 37
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10603 36
(Danio rerio)
Actinopterygii atp10d 36
  • 59.49 (n)
  • 57.27 (a)
atp10d 37
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010026 36
  • 51.06 (n)
  • 48.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33298 36
  • 52.76 (n)
  • 47.98 (a)
CG33298 37
  • 35 (a)
CG18419 38
  • 47 (a)
(Caenorhabditis elegans)
Secernentea tat-3 36
  • 52.29 (n)
  • 45.86 (a)
tat-3 37
  • 36 (a)
tat-4 37
  • 28 (a)
T24H7.5a 38
  • 37 (a)
W09D10.2 38
  • 41 (a)
T24H7.5b 38
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DNF1 37
  • 26 (a)
DNF2 37
  • 25 (a)
(Oryza sativa)
Liliopsida Os.15463 36
(Triticum aestivum)
Liliopsida Ta.20753 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4F10.16c 36
  • 47.46 (n)
  • 39.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
Species with no ortholog for ATP10D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ATP10D Gene

Gene Tree for ATP10D (if available)
Gene Tree for ATP10D (if available)

Paralogs for ATP10D Gene

Paralogs for ATP10D Gene

Selected SIMAP similar genes for ATP10D Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATP10D: view

Variants for ATP10D Gene

Sequence variations from dbSNP and Humsavar for ATP10D Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1058793 - 47,582,029(+) TCATC(A/G)TTCTC missense, reference
rs1316781 -- 47,590,991(-) ATTAC(A/G)GAACC intron-variant
rs1316782 -- 47,587,296(+) GGCAG(C/G)CCACC intron-variant
rs1316783 -- 47,587,373(+) AGAAC(A/G)AAAGT intron-variant
rs1316874 -- 47,587,186(+) ACGAC(A/G)TCCAT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ATP10D Gene

Variant ID Type Subtype PubMed ID
nsv879005 CNV Loss 21882294
nsv829923 CNV Gain 17160897
esv2727527 CNV Deletion 23290073
esv2727528 CNV Deletion 23290073
esv2296261 CNV Deletion 18987734
esv1010678 CNV Deletion 20482838
esv1569407 CNV Deletion 17803354
esv2588788 CNV Insertion 19546169
esv272974 CNV Insertion 20981092
esv268385 CNV Insertion 20981092
esv2727530 CNV Deletion 23290073
nsv528326 CNV Gain 19592680
nsv879006 CNV Loss 21882294
nsv4327 CNV Insertion 18451855

Relevant External Links for ATP10D Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ATP10D Gene

Relevant External Links for ATP10D

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ATP10D: view

No data available for UniProtKB/Swiss-Prot for ATP10D Gene

Publications for ATP10D Gene

  1. Characterization of a putative type IV aminophospholipid transporter P-type ATPase. (PMID: 12532265) Flamant S. … Besmond C. (Mamm. Genome 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genetic determinants of circulating sphingolipid concentrations in European populations. (PMID: 19798445) Hicks A.A. … Campbell H. (PLoS Genet. 2009) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ATP10D Gene

  • antibodies-online peptides for ATP10D
  • antibodies-online antibodies for ATP10D
  • antibodies-online kits for ATP10D

Sources for ATP10D Gene

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