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Aliases for ATP10B Gene

Aliases for ATP10B Gene

  • ATPase Phospholipid Transporting 10B (Putative) 2 3 5
  • P4-ATPase Flippase Complex Alpha Subunit ATP10B 3 4
  • ATPase, Class V, Type 10B 2 3
  • EC 3.6.3.1 4 58
  • ATPVB 3 4
  • Probable Phospholipid-Transporting ATPase VB 3
  • ATPase Class V Type 10B 4
  • KIAA0715 4
  • EC 3.6.3 58

External Ids for ATP10B Gene

Previous GeneCards Identifiers for ATP10B Gene

  • GC05M160108
  • GC05M159925
  • GC05M159971
  • GC05M159922
  • GC05U900563
  • GC05M155082

Summaries for ATP10B Gene

GeneCards Summary for ATP10B Gene

ATP10B (ATPase Phospholipid Transporting 10B (Putative)) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP10D.

UniProtKB/Swiss-Prot for ATP10B Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

Additional gene information for ATP10B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP10B Gene

Genomics for ATP10B Gene

Regulatory Elements for ATP10B Gene

Enhancers for ATP10B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H160691 0.6 ENCODE dbSUPER 20.4 +235.7 235659 3 HLF ATP10B ENSG00000253687 ENSG00000254391
GH05H160836 0.4 ENCODE 28.6 +91.4 91387 2 FOXA2 ATP10B ENSG00000254391
GH05H160702 0.9 FANTOM5 Ensembl 11.4 +226.6 226568 1 NR2F1 CEBPG BCL11A IKZF1 ATF7 IKZF2 RUNX3 SPI1 ATP10B SLU7 ENSG00000254391
GH05H160683 0.8 ENCODE dbSUPER 10.7 +244.9 244855 2 SCRT1 CTCF HLF SCRT2 SMC3 CREB1 RAD21 ATP10B ENSG00000254391 GC05P160665
GH05H160921 1 ENCODE dbSUPER 5.3 +5.6 5576 4 SOX13 ESRRA FOXA2 NFIB BMI1 CTBP1 GATA3 RCOR1 TCF7L2 GATAD2A ATP10B ENSG00000254391
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATP10B on UCSC Golden Path with GeneCards custom track

Genomic Location for ATP10B Gene

Chromosome:
5
Start:
160,563,120 bp from pter
End:
160,929,368 bp from pter
Size:
366,249 bases
Orientation:
Minus strand

Genomic View for ATP10B Gene

Genes around ATP10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATP10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATP10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP10B Gene

Proteins for ATP10B Gene

  • Protein details for ATP10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94823-AT10B_HUMAN
    Recommended name:
    Probable phospholipid-transporting ATPase VB
    Protein Accession:
    O94823
    Secondary Accessions:
    • Q9H725

    Protein attributes for ATP10B Gene

    Size:
    1461 amino acids
    Molecular mass:
    165391 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.
    SequenceCaution:
    • Sequence=BAA34435.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP10B Gene

Selected DME Specific Peptides for ATP10B Gene

O94823:
  • YVNLLFWYQFFCGFS
  • YEAESPDE
  • EGMQAVM
  • LLGATGIEDRLQ
  • FDSVRKRMSVV
  • LLLRGCTIRNTE
  • IGDGANDVSMI
  • VYTKGADSV
  • NDVSMIQ
  • ETKAMLNNSG
  • FSDKTGTLT
  • WVLTGDK
  • DGETNLK
  • LTGDKQETA
  • DKTGTLT
  • PISLYVS
  • RKRMSVV
  • LNNSGPRYKRS

Post-translational modifications for ATP10B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP10B Gene

Domains & Families for ATP10B Gene

Gene Families for ATP10B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ATP10B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94823

UniProtKB/Swiss-Prot:

AT10B_HUMAN :
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP10B: view

Function for ATP10B Gene

Molecular function for ATP10B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
UniProtKB/Swiss-Prot Function:
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

Enzyme Numbers (IUBMB) for ATP10B Gene

Phenotypes From GWAS Catalog for ATP10B Gene

Gene Ontology (GO) - Molecular Function for ATP10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity IEA,IBA --
GO:0005515 protein binding IPI 21914794
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ATP10B: view

Phenotypes for ATP10B Gene

genes like me logo Genes that share phenotypes with ATP10B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ATP10B

CRISPR Products

miRNA for ATP10B Gene

miRTarBase miRNAs that target ATP10B

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ATP10B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATP10B Gene

Localization for ATP10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP10B Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATP10B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
endosome 1

Gene Ontology (GO) - Cellular Components for ATP10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA,IEA 21914794
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATP10B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ATP10B Gene

Pathways & Interactions for ATP10B Gene

genes like me logo Genes that share pathways with ATP10B: view

Pathways by source for ATP10B Gene

Gene Ontology (GO) - Biological Process for ATP10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0015914 phospholipid transport IEA --
GO:0045332 phospholipid translocation IEA,NAS 21914794
genes like me logo Genes that share ontologies with ATP10B: view

No data available for SIGNOR curated interactions for ATP10B Gene

Drugs & Compounds for ATP10B Gene

(399) Additional Compounds for ATP10B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with ATP10B: view

Transcripts for ATP10B Gene

mRNA/cDNA for ATP10B Gene

(7) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP10B Gene

ATPase, class V, type 10B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ATP10B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ATP10B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1: - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:

ExUns: 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1: - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for ATP10B Gene

GeneLoc Exon Structure for
ATP10B
ECgene alternative splicing isoforms for
ATP10B

Expression for ATP10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATP10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP10B Gene

This gene is overexpressed in Colon - Transverse (x12.0) and Brain - Spinal cord (cervical c-1) (x5.0).

Protein differential expression in normal tissues from HIPED for ATP10B Gene

This gene is overexpressed in Adipocyte (50.8) and Colon (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATP10B Gene



Protein tissue co-expression partners for ATP10B Gene

NURSA nuclear receptor signaling pathways regulating expression of ATP10B Gene:

ATP10B

SOURCE GeneReport for Unigene cluster for ATP10B Gene:

Hs.109358

mRNA Expression by UniProt/SwissProt for ATP10B Gene:

O94823-AT10B_HUMAN
Tissue specificity: Found in brain and in low levels in testis.

Evidence on tissue expression from TISSUES for ATP10B Gene

  • Intestine(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ATP10B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ATP10B Gene

Orthologs for ATP10B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP10B 33 34
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia ATP10B 33 34
  • 87.53 (n)
mouse
(Mus musculus)
Mammalia Atp10b 33 16 34
  • 83.73 (n)
cow
(Bos Taurus)
Mammalia ATP10B 34
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp10b 33
  • 82.41 (n)
oppossum
(Monodelphis domestica)
Mammalia ATP10B 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP10B 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP10B 33 34
  • 66.69 (n)
lizard
(Anolis carolinensis)
Reptilia ATP10B 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp10b 33
  • 64.22 (n)
zebrafish
(Danio rerio)
Actinopterygii ATP10B 34
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18419 35
  • 44 (a)
CG33298 34
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W09D10.2 35
  • 40 (a)
T24H7.5b 35
  • 38 (a)
T24H7.5a 35
  • 37 (a)
tat-3 34
  • 35 (a)
ManyToMany
tat-4 34
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DNF1 34
  • 26 (a)
ManyToMany
DNF2 34
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
Species where no ortholog for ATP10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP10B Gene

ENSEMBL:
Gene Tree for ATP10B (if available)
TreeFam:
Gene Tree for ATP10B (if available)

Paralogs for ATP10B Gene

Paralogs for ATP10B Gene

(4) SIMAP similar genes for ATP10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP10B: view

Variants for ATP10B Gene

Sequence variations from dbSNP and Humsavar for ATP10B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000003527 -- 160,596,438(+) ATCAT(A/T)CTGAA intron-variant
rs1000049944 -- 160,650,603(+) AGTAA(C/T)CACCT intron-variant
rs1000068161 -- 160,834,780(+) TTCTA(C/G)CCAAA intron-variant
rs1000068308 -- 160,703,033(+) CAACT(A/G)GAAGA intron-variant
rs1000069330 -- 160,644,697(+) CAGGA(A/G)GTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP10B Gene

Variant ID Type Subtype PubMed ID
esv1140729 CNV deletion 17803354
esv1678762 CNV insertion 17803354
esv2251261 CNV deletion 18987734
esv24641 CNV gain 19812545
esv2671972 CNV deletion 23128226
esv2672450 CNV deletion 23128226
esv2730980 CNV deletion 23290073
esv3335764 CNV insertion 20981092
esv3607372 CNV gain 21293372
esv3607374 CNV loss 21293372
esv3607375 CNV gain 21293372
esv3607377 CNV loss 21293372
esv3607378 CNV loss 21293372
esv3607379 CNV loss 21293372
esv3607380 CNV gain 21293372
esv3607381 CNV loss 21293372
esv3607382 CNV loss 21293372
esv3607383 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv1021499 CNV gain 25217958
nsv1026980 CNV gain 25217958
nsv477559 CNV novel sequence insertion 20440878
nsv5098 CNV insertion 18451855
nsv517932 CNV gain 19592680
nsv525166 CNV loss 19592680
nsv528076 CNV loss 19592680
nsv600167 CNV loss 21841781
nsv830532 CNV loss 17160897

Variation tolerance for ATP10B Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.86; 74.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATP10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATP10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP10B Gene

Disorders for ATP10B Gene

Relevant External Links for ATP10B

Genetic Association Database (GAD)
ATP10B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATP10B

No disorders were found for ATP10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATP10B Gene

Publications for ATP10B Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 60
  4. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck MS … Schlegel RA (Physiological genomics 1999) 2 3 60
  5. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PMID: 21914794) Takatsu H … Shin HW (The Journal of biological chemistry 2011) 3 60

Products for ATP10B Gene

Sources for ATP10B Gene

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