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ATP10B Gene

protein-coding   GIFtS: 52
GCID: GC05M159922

ATPase, Class V, Type 10B

(Previous names: ATPase, Class V, type 10B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ATPase, Class V, Type 10B1 2     KIAA07153
ATPVB2 3     ATPase Class V Type 10B3
EC 3.6.3.13 8     EC 3.6.38
Probable Phospholipid-Transporting ATPase VB2     

External Ids:    HGNC: 135431   Entrez Gene: 231202   Ensembl: ENSG000001183227   UniProtKB: O948233   
ORGUL members:         

Export aliases for ATP10B gene to outside databases

Previous GC identifers: GC05M160108 GC05M160499 GC05M159925 GC05M159971 GC05U900563 GC05M155082


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATP10B Gene:
ATP10B (ATPase, class V, type 10B) is a protein-coding gene. GO annotations related to this gene include phospholipid-translocating ATPase activity and magnesium ion binding. An important paralog of this gene is ATP10D.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATP10B gene promoter:
         Tal-1   CUTL1   NF-AT   E47   NF-AT2   NF-AT3   Cart-1   ARP-1   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ATP10B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATP10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q34   HGNC cytogenetic band: 5q34

ATP10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP10B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M159922:  view genomic region     (about GC identifiers)

Start:
159,990,127 bp from pter      End:
160,279,221 bp from pter
Size:
289,095 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AT10B_HUMAN, O94823 (See protein sequence)
Recommended Name: Probable phospholipid-transporting ATPase VB  
Size: 1461 amino acids; 165391 Da
Sequence caution: Sequence=BAA34435.2; Type=Erroneous initiation;
Secondary accessions: Q9H725
Alternative splicing: 3 isoforms:  O94823-1   O94823-2   O94823-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP10B: NX_O94823

Explore proteomics data for ATP10B at MOPED

Selected DME Specific Peptides for ATP10B (O94823) (see all 18)
 NDVSMIQ  EGMQAVM  WVLTGDK  DGETNLK 


See ATP10B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_079429.2  
ENSEMBL proteins: 
 ENSP00000313600   ENSP00000431081  
Reactome Protein details: O94823

ATP10B Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for ATP10B

 
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Search antibodies-online for proteins for ATP10B 

 
Search antibodies-online for peptides for ATP10B

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antibodies-online antibodies for ATP10B 

ATP10B Assay Products:

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Cloud-Clone Corp. ELISAs for ATP10B
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Search eBioscience for ELISAs for ATP10B 
antibodies-online kits for ATP10B (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PATP: ATPases / P-type

IUPHAR Guide to PHARMACOLOGY protein family classification: ATP10B
Phospholipid-transporting ATPase

Selected InterPro protein domains (see all 6):
 IPR008250 ATPase_P-typ_transduc_dom_A
 IPR023214 HAD-like_dom
 IPR006539 ATPase_P-typ_Plipid-transp
 IPR001757 Cation_transp_P_typ_ATPase
 IPR018303 ATPase_P-typ_P_site

Graphical View of Domain Structure for InterPro Entry O94823

ProtoNet protein and cluster: O94823

1 Blocks protein domain: IPB001757 ATPase

UniProtKB/Swiss-Prot: AT10B_HUMAN, O94823
Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily


Find genes that share domains with ATP10B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AT10B_HUMAN, O94823
Catalytic activity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)

     Enzyme Numbers (IUBMB): EC 3.6.3.11 2 EC 3.6.32

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding ----
GO:0000287magnesium ion binding IEA--
GO:0004012phospholipid-translocating ATPase activity IEA--
GO:0005515protein binding IPI--
GO:0005524ATP binding IEA--
     
Find genes that share ontologies with ATP10B           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ATP10B

miRNA
Products:
    
miRTarBase miRNAs that target ATP10B:
hsa-mir-148b-3p (MIRT019342), hsa-mir-335-5p (MIRT017827)

Block miRNA regulation of human, mouse, rat ATP10B using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ATP10B (see all 19):
hsa-miR-128 hsa-miR-548l hsa-miR-3605-5p hsa-miR-499-5p hsa-miR-1193 hsa-miR-3909 hsa-miR-548c-3p hsa-miR-3163
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Gene Editing
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GenScript: all cDNA clones in your preferred vector: ATP10B (NM_025153)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP10B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP10B

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP10B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AT10B_HUMAN, O94823: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane.
Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane3
cytosol1
nucleus1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA--
GO:0005789endoplasmic reticulum membrane IEA--
GO:0016021integral component of membrane IEA--
GO:0030659cytoplasmic vesicle membrane IEA--

Find genes that share ontologies with ATP10B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ATP10B About    
See pathways by source

SuperPathContained pathways About
1Ion channel transport
Ion channel transport0.58
2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Transmembrane transport of small molecules0.47
3Ion transport by P-type ATPases
Ion transport by P-type ATPases


Find genes that share SuperPaths with ATP10B           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ATP10B
    Ion transport by P-type ATPases


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATP10B
Interactions:

    Search GeneGlobe Interaction Network for ATP10B

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for ATP10B (ENSP000003136004) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
ATP8A1ENSP000003710844STRING: ENSP00000371084
ATP8A2ENSP000003710704STRING: ENSP00000371070
UBBENSP000003046974STRING: ENSP00000304697
UBCENSP000003448184STRING: ENSP00000344818
ATP5DENSP000002153754STRING: ENSP00000215375
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006812cation transport ----
GO:0015914phospholipid transport ----
GO:0045332phospholipid translocation NAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ATP10B (AT10B)

Selected HMDB Compounds for ATP10B (see all 2601)    About this table
CompoundSynonyms CAS #PubMed Ids
PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----
PA(16:0/18:2(9Z,12Z))PA(34:2) (see all 10)----
PA(16:0e/18:0)2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate ;PA(o-16:0/18:0) ----



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ATP10B gene: 
NM_025153.2  

Unigene Cluster for ATP10B:

ATPase, class V, type 10B
Hs.109358  [show with all ESTs]
Unigene Representative Sequence: NM_025153
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000327245(uc010jit.1 uc003lym.1) ENST00000523758 ENST00000517815
ENST00000522169 ENST00000520108(uc003lyn.3) ENST00000326831(uc003lyo.2)
ENST00000517802(uc003lyp.2 uc011deg.1) ENST00000521033 ENST00000518411
ENST00000520098 ENST00000520975
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate ATP10B (see all 19):
hsa-miR-128 hsa-miR-548l hsa-miR-3605-5p hsa-miR-499-5p hsa-miR-1193 hsa-miR-3909 hsa-miR-548c-3p hsa-miR-3163
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ATP10B
Predesigned siRNA for gene silencing in human, mouse, rat ATP10B
Clone
Products:
     
OriGene clones in human, mouse for ATP10B (see all 7)
OriGene ORF clones in mouse, rat for ATP10B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ATP10B (NM_025153)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP10B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP10B
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for ATP10B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATP10B
  QuantiTect SYBR Green Assays in human, mouse, rat ATP10B
  QuantiFast Probe-based Assays in human, mouse, rat ATP10B

Additional mRNA sequence: 

AB018258.2 AK024894.1 AK025130.1 AK025290.1 AK025294.1 AK090832.1 AK295081.1 BC018773.1 
BC108322.1 

8 DOTS entries:

DT.97839669  DT.100746079  DT.40274197  DT.99930531  DT.423994  DT.120859501  DT.40114879  DT.40218376 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATP10B (see all 6)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1:                                                                                      -                                               -                     
SP2:                                                                                                                                      -                     
SP3:                          -                                                                                                                                 
SP4:                                                                                      -                                                                     
SP5:                                                                                                                                                            

ExUns: 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1:  -     -                                             
SP2:  -     -           -                                 
SP3:                                                      
SP4:                                                      
SP5:                                                      


ECgene alternative splicing isoforms for ATP10B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ATP10B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTTTTCCATA
ATP10B Expression
About this image


ATP10B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 NULL (Uncategorized)
         Endoderm progenitor-like cells
 
 Neural Tube (Nervous System)
         Floor plate-like cells
 
 Colon (Gastrointestinal Tract)
ATP10B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ATP10B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.109358

UniProtKB/Swiss-Prot: AT10B_HUMAN, O94823
Tissue specificity: Found in brain and in low levels in testis

    Custom PCR Arrays for ATP10B
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QuantiTect SYBR Green Assays in human, mouse, rat ATP10B
QuantiFast Probe-based Assays in human, mouse, rat ATP10B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP10B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP10B gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Atp10b1 , 5 ATPase, class V, type 10B1, 5 83.73(n)1
83.76(a)1
  11 (25.68 cM)5
3197671  NM_176999.31  NP_795973.21 
 431498775 
chicken
(Gallus gallus)
Aves ATP10B1 ATPase, class V, type 10B 66.69(n)
68.04(a)
  416159  XM_414491.4  XP_414491.3 
lizard
(Anolis carolinensis)
Reptilia ATP10B6
ATPase, class V, type 10B
58(a)
1 ↔ 1
GL343286.1(1382307-1444172)
tropical clawed frog
(Xenopus tropicalis)
Amphibia atp10b1 ATPase, class V, type 10B 64.22(n)
65.66(a)
  100489696  XM_002940128.2  XP_002940174.2 
zebrafish
(Danio rerio)
Actinopterygii ATP10B6
ATPase, class V, type 10B
53(a)
1 ↔ 1
14(23300222-23364569) ENSDARG00000076230
fruit fly
(Drosophila melanogaster)
Insecta CG184193 calcium-transporting ATPase 44(a)     --
worm
(Caenorhabditis elegans)
Secernentea W09D10.23 ATPase 40(a)
(best of 3)
  III(10794590-10801091)   --
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DNF16
DNF26
Aminophospholipid translocase (flippase) that loca...
Aminophospholipid translocase (flippase) that loca...
26(a)
25(a)
many ↔ many
many ↔ many
V(512744-517459) YER166W
IV(631282-636120) YDR093W


ENSEMBL Gene Tree for ATP10B (if available)
TreeFam Gene Tree for ATP10B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ATP10B gene
ATP10D2  ATP10A2  
4 SIMAP similar genes for ATP10B using alignment to 2 protein entries:     AT10B_HUMAN (see all proteins):
ATP10A    ATP10D    ATP8B4    ATP8B2

Find genes that share paralogs with ATP10B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ATP10B (see all 6399)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs339526851,2
C--155253676(+) CACAC-/ATAT  
        
ATATA
1 -- int10--------
rs1851411121,2
--155374737(+) ATGCAA/GGTTAC 1 -- us2k10--------
rs1420117101,2
--155374742(+) GGTTAC/TATAGG 1 -- us2k10--------
rs131638371,2
C,F,A--155374743(+) GTTACG/ATAGGT 1 -- us2k19Minor allele frequency- A:0.12NA WA CSA 17
rs21610961,2
C,F,A,H--159989641(+) TGCCTA/GTCACA 1 -- int19Minor allele frequency- G:0.16NS EA WA CSA NA 770
rs1450585811,2
C--159989741(+) GATTCA/GAGGTT 1 -- int10--------
rs777018411,2
C,F--159989800(+) CTGCAC/TGTGCT 1 -- int12Minor allele frequency- T:0.07NA 122
rs65565011,2
C,F,A,H--159989807(+) TGCTGC/TTTCTA 1 -- int19Minor allele frequency- T:0.17NA WA CSA EA 506
rs1130247361,2
C,F--159989890(+) TATACG/ATTCAG 1 -- int12Minor allele frequency- A:0.08CSA WA 120
rs1388403201,2
--159989948(+) AGACAG/TATTGA 1 -- int10--------

HapMap Linkage Disequilibrium report for ATP10B (159990127 - 160240127 bp, first 250kb of ATP10B)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ATP10B (see all 13):    About this table    
Variant IDTypeSubtypePubMed ID
esv2251261CNV Deletion18987734
esv2671972CNV Deletion23128226
esv1140729CNV Deletion17803354
esv2672450CNV Deletion23128226
esv2730980CNV Deletion23290073
nsv5098CNV Insertion18451855
esv1678762CNV Insertion17803354
nsv525166CNV Loss19592680
nsv883073CNV Loss21882294
nsv830532CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with ATP10B           About GenesLikeMe

Genetic Association Database (GAD): ATP10B

Export disorders for ATP10B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ATP10B gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with ATP10B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (Nature 2004)
  4. Differential expression of putative transbilayer amphipath transporters. (PubMed id 11015572)1, 3 Halleck M.S.... Schlegel R.A. (Physiol. Genomics 1999)
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
  6. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
  7. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
  8. Genome-wide association of sleep and circadian phenotypes. (PubMed id 17903308)4 Gottlieb D.J....Wilk J.B. (BMC Med. Genet. 2007)
  9. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
  10. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23120 HGNC: 13543 Ensembl:ENSG00000118322 euGenes: HUgn23120 ECgene: ATP10B
H-InvDB: ATP10B

(According to HUGE)
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HUGE: KIAA0715

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ATP10B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ATP10B gene:
Search GeneIP for patents involving ATP10B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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