Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATP10B Gene

protein-coding GIFtS: 50
GCID: GC05M159922

ATPase, class V, type 10B

(Previous names: ATPase, Class V, type 10B )

Explore 1 disease affiliated with
ATP10B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ATPase, Class V, Type 10B¹ ²		FLJ21477¹
ATPVB¹ ² ³		Probable Phospholipid-Transporting ATPase VB²
KIAA0715¹ ³		ATPase Class V Type 10B³
EC 3.6.3.1³ ⁸		EC 3.6.3⁸

External Ids:	HGNC: 13543¹	Entrez Gene: 23120²	Ensembl: ENSG00000118322⁷	UniProtKB: O94823³

Export aliases for ATP10B gene to outside databases

Previous GC identifers: GC05M160108 GC05M160499 GC05M159925 GC05M159971 GC05U900563 GC05M155082

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATP10B gene promoter:
Tal-1 CUTL1 NF-AT E47 NF-AT2 NF-AT3 Cart-1 ARP-1 NF-AT1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for ATP10B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP10B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34 Ensembl cytogenetic band: 5q34 HGNC cytogenetic band: 5q34

ATP10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATP10B gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M159922: view genomic region (about GC identifiers)

Start:	159,990,127 bp from pter	End:	160,279,221 bp from pter
Size:	289,095 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AT10B_HUMAN, O94823 (See protein sequence)

Recommended Name: Probable phospholipid-transporting ATPase VB

Size: 1461 amino acids; 165391 Da

Subcellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane.

Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B

Sequence caution: Sequence=BAA34435.2; Type=Erroneous initiation;

Secondary accessions: Q9H725

Alternative splicing: 3 isoforms: O94823-1 O94823-2 O94823-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATP10B: NX_O94823

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94823

4/18 DME Specific Peptides for ATP10B (O94823) (see all 18)

NDVSMIQ

EGMQAVM

WVLTGDK

DGETNLK

ATP10B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079429.2

ENSEMBL proteins:

ENSP00000313600 ENSP00000431081

Reactome Protein details: O94823
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ATP10B
	GenScript Custom Purified and Recombinant Proteins Services for ATP10B
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ATP10B

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030659	cytoplasmic vesicle membrane	IEA	--

ATP10B for ontologies About GeneDecksing

ATP10B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ATP10B
	GenScript Custom Superior Antibodies Services for ATP10B
	Novus Biologicals ATP10B Antibody
	Search for Antibodies for ATP10B at Abcam
	Uscn Antibodies for ATP10B
	Search ThermoFisher Antibodies for ATP10B

Assay Products for ATP10B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ATP10B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ATP10B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATP10B for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR023306 ATPase_cation_domN

IPR023299 ATPase_P-typ_cyto_domN

IPR008250 ATPase_P-typ_transduc_dom_A

IPR023214 HAD-like_dom

IPR006539 ATPase_P-typ_Plipid-transp

Graphical View of Domain Structure for InterPro Entry O94823

ProtoNet protein and cluster: O94823

1 Blocks protein family: IPB001757 ATPase

UniProtKB/Swiss-Prot: AT10B_HUMAN, O94823

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AT10B_HUMAN, O94823

Catalytic activity: ATP + H(2)O + phospholipid(side 1) = ADP + phosphate + phospholipid(side 2)

Enzyme Numbers (IUBMB): EC 3.6.3.1¹ ² EC 3.6.3²

miRNA Products:		OriGene 3'-UTR Clone: ATP10B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATP10B
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP10B (see all 19):
		hsa-miR-128 hsa-miR-548l hsa-miR-3605-5p hsa-miR-499-5p hsa-miR-1193 hsa-miR-3909 hsa-miR-548c-3p hsa-miR-3163

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP10B (see all 4) OriGene shRNA RFP: ATP10B Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP10B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ATP10B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP10B (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP10B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ATP10B (NM_025153)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP10B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP10B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ATP10B
		Search LifeMap BioReagents cell lines for ATP10B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP10B

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004012	phospholipid-translocating ATPase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	IEA	--

ATP10B for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ion channel transport

Ion channel transport

1.00

Ion transport by P-type ATPases

0.32

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for ATP10B

	Transmembrane transport of small molecules
	Ion channel transport
	Ion transport by P-type ATPases

ATP10B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ATP10B

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006812	cation transport	IEA	--
GO:0045332	phospholipid translocation	NAS	--

ATP10B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ATP10B

10/2601 HMDB Compounds for ATP10B (see all 2601) About this table

Compound	Synonyms	CAS #	PubMed Ids
PC(O-16:0/18:2(9Z,12Z))	1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)	88542-95-4	12486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)	--	12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)	103597-60-0	12486725
PE(P-16:0e/0:0)	2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e)	--	12486725
PE(P-16:0e/18:1(9Z))	2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine	--	12486725
PA(16:0/16:0)	Dipalmitoylphosphatidic acid (see all 25)	7091-44-3	--
PA(16:0/18:1(11Z))	PA(16:0/18:1n7) (see all 10)	--	--
PA(16:0/18:1(9Z))	PA(16:0/18:1n9) (see all 10)	--	--
PA(16:0/18:2(9Z,12Z))	PA(34:2) (see all 10)	--	--
PA(16:0e/18:0)	2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate ;PA(o-16:0/18:0)	--	--

Search CenterWatch for drugs/clinical trials and news about ATP10B / AT10B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATP10B gene:

NM_025153.2

Unigene Cluster for ATP10B:

ATPase, class V, type 10B

Hs.109358 [show with all ESTs]

Unigene Representative Sequence: NM_025153

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000327245(uc010jit.1 uc003lym.1) ENST00000523758 ENST00000517815

ENST00000522169 ENST00000520108(uc003lyn.3) ENST00000326831(uc003lyo.2)

ENST00000517802(uc003lyp.2 uc011deg.1) ENST00000521033 ENST00000518411

ENST00000520098 ENST00000520975

miRNA Products:		OriGene 3'-UTR Clone: ATP10B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATP10B
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate ATP10B (see all 19):
		hsa-miR-128 hsa-miR-548l hsa-miR-3605-5p hsa-miR-499-5p hsa-miR-1193 hsa-miR-3909 hsa-miR-548c-3p hsa-miR-3163

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP10B (see all 4) OriGene shRNA RFP: ATP10B Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP10B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP10B (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP10B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ATP10B (NM_025153)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATP10B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP10B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP10B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ATP10B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP10B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP10B

Additional cDNA sequence:

AB018258.2 AK024894.1 AK025130.1 AK025290.1 AK025294.1 AK090832.1 AK295081.1 BC018773.1

BC108322.1

8 DOTS entries:

DT.97839669 DT.100746079 DT.40274197 DT.99930531 DT.423994 DT.120859501 DT.40114879 DT.40218376

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ATP10B (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^	20a	·
SP1:																													-																-
SP2:																																													-
SP3:									-
SP4:																													-
SP5:

ExUns:	20b	^	21	^	22	^	23	^	24	^	25	^	26	^	27a	·	27b
SP1:	-		-
SP2:	-		-				-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ATP10B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATP10B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTTCCATA

About this image

ATP10B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Endoderm progenitor-like cells (Generation and expan...)

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ATP10B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATP10B

SOURCE GeneReport for Unigene cluster: Hs.109358

UniProtKB/Swiss-Prot: AT10B_HUMAN, O94823

Tissue specificity: Found in brain and in low levels in testis

SABiosciences Custom PCR Arrays for ATP10B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP10B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ATP10B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP10B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP10B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP10B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP10B gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Atp10b^{1 , 5}	ATPase, class V, type 10B^{1, 5}	83.73(n)¹ 83.82(a)¹		11 (25.68 cM)⁵ 319767¹ NM_176999.3¹ NP_795973.2¹ 43149877⁵
chicken (Gallus gallus)	Aves	ATP10B¹	ATPase, class V, type 10B	67.02(n) 68.13(a)		416159 XM_414491.3 XP_414491.3
lizard (Anolis carolinensis)	Reptilia	ATP10B⁶	--	66(a)	1 ↔ 1	GL343286.1(1383754-1464071)
zebrafish (Danio rerio)	Actinopterygii	atp10a¹	ATPase, class V, type 10A	59.77(n) 57.22(a)		563932 XM_687291.4 XP_692383.4
fruit fly (Drosophila melanogaster)	Insecta	CG18419³	calcium-transporting ATPase	44(a)		--
worm (Caenorhabditis elegans)	Secernentea	W09D10.2³	ATPase	40(a) (best of 3)		III(10794590-10801091) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ALA1¹	phospholipid-transporting ATPase 1	51.06(n) 43.17(a)		830375 NM_120575.2 NP_568146.1
rice (Oryza sativa)	Liliopsida	Os01g0277600¹	hypothetical protein	51.12(n) 43.45(a)		4324268 NM_001049271.2 NP_001042736.2

ENSEMBL Gene Tree for ATP10B (if available)
TreeFam Gene Tree for ATP10B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ATP10B gene

ATP10D² ATP10A²

6 SIMAP similar genes for ATP10B using alignment to 2 protein entries: AT10B_HUMAN (see all proteins):

ATP10A ATP10D ATP8B4 ATP8B2 ATP8A1 ATP8A2

ATP10B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2161096^1,2	C,F,A,H,	--	159989641(+)	`TGCCTA/GTCACA`	1	--	int¹		9		NS EA WA CSA NA	770
rs145058581^1,2		--	159989741(+)	`GATTCA/GAGGTT`	1	--	int¹		0	--	--	--	--
rs77701841^1,2	C,	--	159989800(+)	`CTGCAC/TGTGCT`	1	--	int¹		2		NA	122
rs6556501^1,2	C,F,A,H,	--	159989807(+)	`TGCTGC/TTTCTA`	1	--	int¹		9		NA WA CSA EA	506
rs113024736^1,2		--	159989890(+)	`TATACG/ATTCAG`	1	--	int¹		2		CSA WA	120
rs138840320^1,2		--	159989948(+)	`AGACAG/TATTGA`	1	--	int¹		0	--	--	--	--
rs11959870^1,2	C,F,A,H,	--	159990141(+)	`AACTAT/CGGAAA`	1	--	ut3¹		30		NA NS EA WA CSA	2904
rs6892951^1,2	C,F,A,H,	--	159990183(+)	`TCCAAT/ACAGTA`	1	--	ut3¹ ese³		16		NA NS EA WA	1344
rs112488799^1,2	C,	--	159990193(+)	`AAAATA/GTCATA`	1	--	ut3¹		2		WA	120
rs141976706^1,2		--	159990216(+)	`TGTACC/TAAGTA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ATP10B (159990127 - 160240127 bp, first 250kb of ATP10B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for ATP10B
7 CNVs: 69244 93328 81101 69243 93329 81103 81100
4 Indels: 46797 27841 81102 93327

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP10B

DNA2.0 Custom Variant and Variant Library Synthesis for ATP10B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ATP10B for disorders About GeneDecksing

1 disease for ATP10B: About MalaCards

pharyngitis

Export disorders for ATP10B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ATP10B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ATP10B)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2, 3} Nagase T.... Ohara O. (1998)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)^{1, 2} Schmutz J.... Rubin E.M. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Differential expression of putative transbilayer amphipath transporters. (PubMed id 11015572)^{1, 3} Halleck M.S.... Schlegel R.A. (1999)
Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)⁶ Kurz M....Kramer W. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23120	HGNC: 13543	Ensembl:ENSG00000118322	euGenes: HUgn23120	ECgene: ATP10B
H-InvDB: ATP10B

(According to HUGE)
About This Section

HUGE: KIAA0715

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ATP10B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ATP10B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ATP10B gene:
Search GeneIP for patents involving ATP10B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ATP10B
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATP10B		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATP10B
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for ATP10B
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATP10B		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATP10B
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ATP10B		OriGene Custom Protein Services for ATP10B
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATP10B
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATP10B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATP10B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATP10B
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATP10B
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATP10B

	GenScript Custom Purified and Recombinant Proteins Services for ATP10B		GenScript cDNA clones with any tag delivered in your preferred vector for ATP10B
	GenScript Custom Assay Services for ATP10B		GenScript Custom Superior Antibodies Services for ATP10B
	GenScript Custom overexpressing Cell Line Services for ATP10B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ATP10B promoter
	Search Chromatin IP Primers for ATP10B
	RT² qPCR Primer Assay in human, mouse, rat ATP10B
	Search GNC Networks for ATP10B
	SABiosciences Custom PCR Arrays for ATP10B

Search Tocris compounds for ATP10B

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ATP10B antibodies

	Search for Antibodies for ATP10B at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ATP10B
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ATP10B Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ATP10B

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATP10B

	Browse SwitchGear 3'UTR luciferase reporter plasmids for ATP10B
	Browse SwitchGear Promoter luciferase reporter plasmids for ATP10B

Search ThermoFisher Antibodies for ATP10B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATP10B

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ATP10B gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ATP10B Gene

ATPase, class V, type 10B

Aliases
for ATP10B gene

Summaries
for ATP10B gene

Genomic Views
for ATP10B gene

Proteins
for ATP10B gene

Protein Domains /
Families
for ATP10B gene

Function
for ATP10B gene

Pathways & Interactions
for ATP10B gene

Drugs & Compounds
for ATP10B gene

Transcripts
for ATP10B gene

Expression
for ATP10B gene

Orthologs
for ATP10B gene

Paralogs
for ATP10B gene

Genomic Variants
for ATP10B gene

Disorders / Diseases
for ATP10B gene

Publications
for ATP10B gene

External Searches for ATP10B gene

Genome Databases showing ATP10B gene

Other Databases showing ATP10B gene

Specialized Databases showing ATP10B gene

Intellectual Property
for ATP10B gene

Products
for ATP10B gene

View Random Gene

Advanced Search

Export list of displayed genes

ATP10B Gene

ATPase, class V, type 10B

Aliasesfor ATP10B gene

Summariesfor ATP10B gene

Genomic Viewsfor ATP10B gene

Proteinsfor ATP10B gene

Protein Domains /Familiesfor ATP10B gene

Functionfor ATP10B gene

Pathways & Interactionsfor ATP10B gene

Drugs & Compoundsfor ATP10B gene

Transcriptsfor ATP10B gene

Expression for ATP10B gene

Orthologsfor ATP10B gene

Paralogsfor ATP10B gene

Genomic Variantsfor ATP10B gene

Disorders / Diseasesfor ATP10B gene

Publicationsfor ATP10B gene

External Searches for ATP10B gene

Genome Databases showing ATP10B gene

Other Databases showing ATP10B gene

Specialized Databases showing ATP10B gene

Intellectual Propertyfor ATP10B gene

Productsfor ATP10B gene

View Random Gene

Aliases
for ATP10B gene

Summaries
for ATP10B gene

Genomic Views
for ATP10B gene

Proteins
for ATP10B gene

Protein Domains /
Families
for ATP10B gene

Function
for ATP10B gene

Pathways & Interactions
for ATP10B gene

Drugs & Compounds
for ATP10B gene

Transcripts
for ATP10B gene

Expression
for ATP10B gene

Orthologs
for ATP10B gene

Paralogs
for ATP10B gene

Genomic Variants
for ATP10B gene

Disorders / Diseases
for ATP10B gene

Publications
for ATP10B gene

Intellectual Property
for ATP10B gene

Products
for ATP10B gene