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Aliases for ATP10B Gene

Aliases for ATP10B Gene

  • ATPase, Class V, Type 10B 2 3
  • P4-ATPase Flippase Complex Alpha Subunit ATP10B 3 4
  • EC 3.6.3.1 4 63
  • ATPVB 3 4
  • Probable Phospholipid-Transporting ATPase VB 3
  • ATPase Class V Type 10B 4
  • KIAA0715 4
  • EC 3.6.3 63

External Ids for ATP10B Gene

Summaries for ATP10B Gene

GeneCards Summary for ATP10B Gene

ATP10B (ATPase, Class V, Type 10B) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion binding and phospholipid-translocating ATPase activity. An important paralog of this gene is ATP10A.

UniProtKB/Swiss-Prot for ATP10B Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP10B Gene

Genomics for ATP10B Gene

Genomic Location for ATP10B Gene

Start:
160,563,120 bp from pter
End:
160,852,214 bp from pter
Size:
289,095 bases
Orientation:
Minus strand

Genomic View for ATP10B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP10B Gene

Regulatory Elements for ATP10B Gene

Proteins for ATP10B Gene

  • Protein details for ATP10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94823-AT10B_HUMAN
    Recommended name:
    Probable phospholipid-transporting ATPase VB
    Protein Accession:
    O94823
    Secondary Accessions:
    • Q9H725

    Protein attributes for ATP10B Gene

    Size:
    1461 amino acids
    Molecular mass:
    165391 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.
    SequenceCaution:
    • Sequence=BAA34435.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ATP10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP10B Gene

Proteomics data for ATP10B Gene at MOPED

Post-translational modifications for ATP10B Gene

No Post-translational modifications

Other Protein References for ATP10B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ATP10B Gene

Gene Families for ATP10B Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

Suggested Antigen Peptide Sequences for ATP10B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94823

UniProtKB/Swiss-Prot:

AT10B_HUMAN
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.:
    • O94823
genes like me logo Genes that share domains with ATP10B: view

Function for ATP10B Gene

Molecular function for ATP10B Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
UniProtKB/Swiss-Prot Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

Enzyme Numbers (IUBMB) for ATP10B Gene

Gene Ontology (GO) - Molecular Function for ATP10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity IBA --
GO:0005515 protein binding IPI 21914794
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATP10B: view

miRNA for ATP10B Gene

miRTarBase miRNAs that target ATP10B

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP10B Gene

Localization for ATP10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP10B Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP10B Gene COMPARTMENTS Subcellular localization image for ATP10B gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 21914794
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with ATP10B: view

Pathways for ATP10B Gene

genes like me logo Genes that share pathways with ATP10B: view

Pathways by source for ATP10B Gene

Interacting Proteins for ATP10B Gene

Gene Ontology (GO) - Biological Process for ATP10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0008152 metabolic process IEA --
GO:0015914 phospholipid transport --
GO:0045332 phospholipid translocation NAS 21914794
GO:0098655 cation transmembrane transport --
genes like me logo Genes that share ontologies with ATP10B: view

Compounds for ATP10B Gene

(2601) HMDB Compounds for ATP10B Gene

Compound Synonyms Cas Number PubMed IDs
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
PA(16:0/18:2(9Z,12Z))
  • PA(34:2)
Not Available
PA(16:0e/18:0)
  • 2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
Not Available
genes like me logo Genes that share compounds with ATP10B: view

Transcripts for ATP10B Gene

mRNA/cDNA for ATP10B Gene

(7) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATP10B Gene

ATPase, class V, type 10B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATP10B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1: - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:

ExUns: 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1: - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for ATP10B Gene

GeneLoc Exon Structure for
ATP10B
ECgene alternative splicing isoforms for
ATP10B

Expression for ATP10B Gene

mRNA expression in normal human tissues for ATP10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP10B Gene

This gene is overexpressed in Colon - Transverse (12.0) and Brain - Spinal cord (cervical c-1) (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP10B Gene

SOURCE GeneReport for Unigene cluster for ATP10B Gene Hs.109358

mRNA Expression by UniProt/SwissProt for ATP10B Gene

O94823-AT10B_HUMAN
Tissue specificity: Found in brain and in low levels in testis
genes like me logo Genes that share expressions with ATP10B: view

Orthologs for ATP10B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATP10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATP10B 35
  • 99.22 (n)
  • 99.38 (a)
ATP10B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATP10B 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP10B 35
  • 87.53 (n)
  • 85.96 (a)
ATP10B 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp10b 35
  • 83.73 (n)
  • 83.76 (a)
Atp10b 16
Atp10b 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATP10B 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP10B 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp10b 35
  • 82.41 (n)
  • 83.03 (a)
chicken
(Gallus gallus)
Aves ATP10B 35
  • 66.69 (n)
  • 68.04 (a)
ATP10B 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP10B 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp10b 35
  • 64.22 (n)
  • 65.66 (a)
zebrafish
(Danio rerio)
Actinopterygii ATP10B 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33298 36
  • 33 (a)
OneToMany
CG18419 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea tat-3 36
  • 35 (a)
ManyToMany
tat-4 36
  • 28 (a)
ManyToMany
T24H7.5a 37
  • 37 (a)
W09D10.2 37
  • 40 (a)
T24H7.5b 37
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DNF1 36
  • 26 (a)
ManyToMany
DNF2 36
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for ATP10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP10B Gene

ENSEMBL:
Gene Tree for ATP10B (if available)
TreeFam:
Gene Tree for ATP10B (if available)

Paralogs for ATP10B Gene

Paralogs for ATP10B Gene

Selected SIMAP similar genes for ATP10B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATP10B: view

Variants for ATP10B Gene

Sequence variations from dbSNP and Humsavar for ATP10B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs888747 -- 160,618,157(-) AGGAC(C/T)CCCTG intron-variant
rs891918 -- 160,680,091(+) GTTTG(C/T)AAAAA intron-variant
rs958911 -- 160,670,625(-) GTGCG(C/T)GTGGG reference, synonymous-codon
rs958912 - 160,670,489(-) AAAGA(C/T)GTGTC missense, reference
rs962271 -- 160,627,542(-) AAGAC(A/G)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP10B Gene

Variant ID Type Subtype PubMed ID
nsv883073 CNV Loss 21882294
esv1140729 CNV Deletion 17803354
esv2251261 CNV Deletion 18987734
esv1678762 CNV Insertion 17803354
esv2730980 CNV Deletion 23290073
esv2672450 CNV Deletion 23128226
nsv5098 CNV Insertion 18451855
esv2671972 CNV Deletion 23128226
esv24641 CNV Gain 19812545
nsv525166 CNV Loss 19592680
nsv517932 CNV Gain 19592680
nsv528076 CNV Loss 19592680
nsv830532 CNV Loss 17160897

Relevant External Links for ATP10B Gene

HapMap Linkage Disequilibrium report
ATP10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP10B Gene

Disorders for ATP10B Gene

Relevant External Links for ATP10B

Genetic Association Database (GAD)
ATP10B
genes like me logo Genes that share disorders with ATP10B: view

No data available for UniProtKB/Swiss-Prot for ATP10B Gene

Publications for ATP10B Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4
  5. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. (PMID: 21914794) Takatsu H. … Shin H.W. (J. Biol. Chem. 2011) 3

Products for ATP10B Gene

Sources for ATP10B Gene

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