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Aliases for ATP10A Gene

Aliases for ATP10A Gene

  • ATPase, Class V, Type 10A 2 3
  • ATP10C 3 4 6
  • ATPVC 3 4 6
  • P4-ATPase Flippase Complex Alpha Subunit ATP10A 3 4
  • Aminophospholipid Translocase VA 3 4
  • ATPase, Class V, Type 10C 2 3
  • EC 3.6.3.1 4 63
  • ATPVA 3 4
  • ATPase Type IV, Phospholipid Transporting (P-Type) 3
  • Probable Phospholipid-Transporting ATPase VA 3
  • Phospholipid-Transporting ATPase VA 3
  • ATPase Class V Type 10A 4
  • KIAA0566 4
  • EC 3.6.3 63

External Ids for ATP10A Gene

Previous HGNC Symbols for ATP10A Gene

  • ATP10C

Previous GeneCards Identifiers for ATP10A Gene

  • GC15U990117
  • GC15M018670
  • GC15M023340
  • GC15M023469
  • GC15M023473
  • GC15M025923
  • GC15M004050

Summaries for ATP10A Gene

Entrez Gene Summary for ATP10A Gene

  • The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATP10A Gene

ATP10A (ATPase, Class V, Type 10A) is a Protein Coding gene. Diseases associated with ATP10A include angelman syndrome. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion binding and phospholipid-translocating ATPase activity. An important paralog of this gene is ATP10D.

UniProtKB/Swiss-Prot for ATP10A Gene

  • Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

Gene Wiki entry for ATP10A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATP10A Gene

Genomics for ATP10A Gene

Regulatory Elements for ATP10A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATP10A Gene

Start:
25,677,273 bp from pter
End:
25,865,172 bp from pter
Size:
187,900 bases
Orientation:
Minus strand

Genomic View for ATP10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATP10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATP10A Gene

Proteins for ATP10A Gene

  • Protein details for ATP10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60312-AT10A_HUMAN
    Recommended name:
    Probable phospholipid-transporting ATPase VA
    Protein Accession:
    O60312
    Secondary Accessions:
    • Q4G0S9
    • Q969I4

    Protein attributes for ATP10A Gene

    Size:
    1499 amino acids
    Molecular mass:
    167688 Da
    Quaternary structure:
    • Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.

    Alternative splice isoforms for ATP10A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATP10A Gene

Proteomics data for ATP10A Gene at MOPED

Post-translational modifications for ATP10A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATP10A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ATP10A Gene

Gene Families for ATP10A Gene

HGNC:
  • PATP :ATPases / P-type
IUPHAR :

Suggested Antigen Peptide Sequences for ATP10A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60312

UniProtKB/Swiss-Prot:

AT10A_HUMAN :
  • O60312
Family:
  • Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
genes like me logo Genes that share domains with ATP10A: view

Function for ATP10A Gene

Molecular function for ATP10A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
UniProtKB/Swiss-Prot Function:
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).

Enzyme Numbers (IUBMB) for ATP10A Gene

Gene Ontology (GO) - Molecular Function for ATP10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IEA --
GO:0004012 phospholipid-translocating ATPase activity NAS 11353404
GO:0005515 protein binding IPI 21914794
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ATP10A: view

Phenotypes for ATP10A Gene

GenomeRNAi human phenotypes for ATP10A:
genes like me logo Genes that share phenotypes with ATP10A: view

Animal Model Products

miRNA for ATP10A Gene

miRTarBase miRNAs that target ATP10A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ATP10A Gene

Localization for ATP10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATP10A Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATP10A Gene COMPARTMENTS Subcellular localization image for ATP10A gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for ATP10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 21914794
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 11353404
genes like me logo Genes that share ontologies with ATP10A: view

Pathways for ATP10A Gene

genes like me logo Genes that share pathways with ATP10A: view

Pathways by source for ATP10A Gene

Interacting Proteins for ATP10A Gene

Gene Ontology (GO) - Biological Process for ATP10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0008152 metabolic process IEA --
GO:0008360 regulation of cell shape NAS 11353404
GO:0015914 phospholipid transport --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with ATP10A: view

Compounds for ATP10A Gene

(2605) HMDB Compounds for ATP10A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
genes like me logo Genes that share compounds with ATP10A: view

Transcripts for ATP10A Gene

Unigene Clusters for ATP10A Gene

ATPase, class V, type 10A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATP10A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATP10A Gene

No ASD Table

Relevant External Links for ATP10A Gene

GeneLoc Exon Structure for
ATP10A
ECgene alternative splicing isoforms for
ATP10A

Expression for ATP10A Gene

mRNA expression in normal human tissues for ATP10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATP10A Gene

This gene is overexpressed in Artery - Aorta (4.7), Artery - Tibial (4.3), and Artery - Coronary (4.2).

Protein differential expression in normal tissues for ATP10A Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATP10A Gene

SOURCE GeneReport for Unigene cluster for ATP10A Gene Hs.659258

mRNA Expression by UniProt/SwissProt for ATP10A Gene

O60312-AT10A_HUMAN
Tissue specificity: Widely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine
genes like me logo Genes that share expressions with ATP10A: view

Expression partners for ATP10A Gene

In Situ Assay Products

Orthologs for ATP10A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATP10A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATP10A 35
  • 83.69 (n)
  • 82.3 (a)
ATP10A 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATP10A 35
  • 85.16 (n)
  • 86.15 (a)
ATP10A 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atp10a 35
  • 81.66 (n)
  • 82.67 (a)
Atp10a 16
Atp10a 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATP10A 35
  • 99.13 (n)
  • 99.2 (a)
ATP10A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp10a 35
  • 81.18 (n)
  • 82.81 (a)
oppossum
(Monodelphis domestica)
Mammalia ATP10A 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATP10A 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATP10A 35
  • 68.67 (n)
  • 71.98 (a)
ATP10A 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATP10A 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atp10a 35
  • 68.55 (n)
  • 73.59 (a)
zebrafish
(Danio rerio)
Actinopterygii atp10a 35
  • 68.8 (n)
  • 72.02 (a)
atp10a 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33298 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tat-3 36
  • 35 (a)
ManyToMany
tat-4 36
  • 28 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR120C 35
  • 48.99 (n)
  • 41.5 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17644g 35
  • 46.9 (n)
  • 41.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DNF1 35
  • 46.57 (n)
  • 41.01 (a)
DNF1 36
  • 27 (a)
ManyToMany
DNF2 36
  • 25 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ALA1 35
  • 49.55 (n)
  • 42.92 (a)
rice
(Oryza sativa)
Liliopsida Os01g0277600 35
  • 51.21 (n)
  • 43.45 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07443 35
  • 50.44 (n)
  • 39.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC24B11.12c 35
  • 46.14 (n)
  • 39.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ATP10A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATP10A Gene

ENSEMBL:
Gene Tree for ATP10A (if available)
TreeFam:
Gene Tree for ATP10A (if available)

Paralogs for ATP10A Gene

Paralogs for ATP10A Gene

Selected SIMAP similar genes for ATP10A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ATP10A Gene

genes like me logo Genes that share paralogs with ATP10A: view

Variants for ATP10A Gene

Sequence variations from dbSNP and Humsavar for ATP10A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs744280 -- 25,715,482(+) CTCAC(C/T)CTTCA intron-variant
rs753898 -- 25,702,127(+) TGAGC(C/G)AACCC intron-variant
rs753899 -- 25,702,495(+) AAATA(C/T)AGTCT intron-variant
rs872537 -- 25,803,058(-) AAGAC(A/T)CAGCC intron-variant
rs872538 -- 25,802,888(-) ACATC(C/T)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATP10A Gene

Variant ID Type Subtype PubMed ID
nsv483024 CNV Loss 15286789
nsv456732 CNV Loss 19166990
nsv527556 CNV Loss 19592680
nsv512389 CNV Loss 21212237
esv2440000 CNV Deletion 19546169
nsv9201 CNV Gain+Loss 18304495
esv2346004 CNV Deletion 18987734
dgv427n67 CNV Loss 20364138
nsv820339 CNV Deletion 20802225
esv2749465 CNV Deletion 23290073
esv7296 CNV Loss 19470904
esv2660747 CNV Deletion 23128226
esv1007072 CNV Gain 20482838
esv27156 CNV Gain+Loss 19812545
esv1005072 CNV Gain 20482838
nsv827260 CNV Loss 20364138
nsv903726 CNV Loss 21882294
nsv903727 CNV Loss 21882294
esv2749466 CNV Deletion 23290073
esv275525 CNV Loss 21479260
esv1673422 CNV Insertion 17803354

Relevant External Links for ATP10A Gene

HapMap Linkage Disequilibrium report
ATP10A
Human Gene Mutation Database (HGMD)
ATP10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATP10A Gene

Disorders for ATP10A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ATP10A Gene in MalaCards »

(1) Diseases for ATP10A Gene including...

UniProtKB/Swiss-Prot

AT10A_HUMAN
  • Angelman syndrome (AS) [MIM:105830]: A neurodevelopmental disorder characterized by severe motor and intellectual retardation, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, open-mouthed expression revealing the tongue. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for ATP10A Gene

Relevant External Links for ATP10A

Genetic Association Database (GAD)
ATP10A
Human Genome Epidemiology (HuGE) Navigator
ATP10A
genes like me logo Genes that share disorders with ATP10A: view

No data available for OMIM , Novoseek inferred disease relationships and Genatlas for ATP10A Gene

Publications for ATP10A Gene

  1. A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome. (PMID: 11326269) Meguro M. … Oshimura M. (Nat. Genet. 2001) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Differential expression of putative transbilayer amphipath transporters. (PMID: 11015572) Halleck M.S. … Schlegel R.A. (Physiol. Genomics 1999) 2 3
  4. The human aminophospholipid-transporting ATPase gene ATP10C maps adjacent to UBE3A and exhibits similar imprinted expression. (PMID: 11353404) Herzing L.B.K. … Ledbetter D.H. (Am. J. Hum. Genet. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ATP10A Gene

Sources for ATP10A Gene

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