Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATOX1 Gene

protein-coding   GIFtS: 61
GCID: GC05M151102

ATX1 antioxidant protein 1 homolog (yeast)

(Previous names: ATX1 (antioxidant protein 1, yeast) homolog 1 )
 Explore 7 diseases affiliated with
ATOX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATOX1    

Aliases
for ATOX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ATX1 Antioxidant Protein 1 Homolog (Yeast)1 2
HAH11 2 3 5
Metal Transport Protein ATX12 3
ATX1 (Antioxidant Protein 1, Yeast) Homolog 11
ATX12
Copper Transport Protein ATOX12

External Ids:    HGNC: 7981   Entrez Gene: 4752   Ensembl: ENSG000001775567   OMIM: 6022705   UniProtKB: O002443   

Export aliases for ATOX1 gene to outside databases

Previous GC identifers: GC05M151191 GC05M151719 GC05M151105 GC05M151150 GC05M146267


Summaries
for ATOX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ATOX1:
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic
copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also
functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in
cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ATOX1_HUMAN, O00244
Function: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant
defense

Gene Wiki entry for ATOX1


Genomic Views
for ATOX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATOX1 gene promoter:
         CREB   p53   Pax-4a   Arnt   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATOX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATOX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q32

ATOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATOX1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M151102:  view genomic region     (about GC identifiers)

Start:
 151,121,877 bp from pter      End:
 151,152,093 bp from pter
Size:
 30,217 bases      Orientation:
 minus strand

Proteins
for ATOX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATOX1_HUMAN, O00244 (See protein sequence)
Recommended Name: Copper transport protein ATOX1  
Size: 68 amino acids; 7402 Da
Subunit: Interacts with ATP7B
6/9 PDB 3D structures from and Proteopedia for ATOX1 (see all 9):
1FE0 (3D)        1FE4 (3D)        1FEE (3D)        1TL4 (3D)        1TL5 (3D)        2K1R (3D)    
Secondary accessions: A8KAJ8 D3DQI2 Q2M1R6 Q56AP3

Explore the universe of human proteins at neXtProt for ATOX1: NX_O00244

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00244

    • ATOX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004036.1  
    ENSEMBL proteins: 
     ENSP00000429366   ENSP00000429982   ENSP00000430028   ENSP00000430598   ENSP00000429814  
     ENSP00000316854  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ATOX1
    OriGene Custom Protein Services for ATOX1 
    GenScript Custom Purified and Recombinant Proteins Services for ATOX1
    Novus Biologicals ATOX1 Proteins
    Novus Biologicals ATOX1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ATOX1
    Uscn Proteins for ATOX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS12029094


    ATOX1 for ontologies           About GeneDecksing



    ATOX1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: ATOX1
    OriGene Custom Antibody Services for ATOX1 
    GenScript Custom Superior Antibodies Services for ATOX1
    Novus Biologicals ATOX1 Antibodies
    Abcam antibodies for ATOX1 
    Uscn Antibodies for ATOX1
    ThermoFisher Antibodies for ATOX1

    Assay Products for ATOX1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATOX1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ATOX1

    Protein Domains /
    Families
    for ATOX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATOX1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006121 HeavyMe-assoc_HMA
     IPR017969 Heavy-metal-associated_CS

    Graphical View of Domain Structure for InterPro Entry O00244

    ProtoNet protein and cluster: O00244

    1 Blocks protein family: IPB006121 Heavy metal transport/detoxification protein

    UniProtKB/Swiss-Prot: ATOX1_HUMAN, O00244
    Similarity: Belongs to the ATX1 family
    Similarity: Contains 1 HMA domain


    Function
    for ATOX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATOX1_HUMAN, O00244
    Function: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant
    defense

         Genatlas biochemistry entry for ATOX1:
    antioxidant protein 1,human homolog of S cerevisiae,copper binding protein Atx1p,ubiquitously expressed,involved in
    copper homeostasis

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ATOX1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATOX1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ATOX1 (see all 9):
    hsa-miR-137 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-133b hsa-miR-133a hsa-miR-363
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATOX1 (see all 7)
    OriGene shRNA RFP: ATOX1
    OriGene siRNA: ATOX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATOX1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ATOX1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATOX1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATOX1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ATOX1 (NM_004045)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATOX1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ATOX1
    Search LifeMap BioReagents cell lines for ATOX1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ATOX1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding IDA12029094
    GO:0016530metallochaperone activity TAS15670166
    GO:0016531copper chaperone activity IDA12029094
    GO:0032767copper-dependent protein binding IPI10497213
    GO:0046872metal ion binding ----


    ATOX1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ATOX1:
     Decreased nuclei size in G2M 

    Animal Models:
         12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atox1):
     behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  nervous system  other  pigmentation 
     respiratory system  vision/eye 

    ATOX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATOX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mineral absorption
    		Mineral absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for ATOX1):
        Mineral absorption


    ATOX1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATOX1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for ATOX1 (O002443 ENSP000003168544) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP7AQ046563, ENSP000003457284I2D: score=3 STRING: ENSP00000345728
    FKBP4Q027903, ENSP000000010084I2D: score=1 STRING: ENSP00000001008
    ATP7BP356703, ENSP000002428394I2D: score=2 STRING: ENSP00000242839
    UBCENSP000003448184STRING: ENSP00000344818
    --Q762B63I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006825copper ion transport TAS15670166
    GO:0006878cellular copper ion homeostasis IEA--
    GO:0006979response to oxidative stress IEA--
    GO:0030001metal ion transport ----


    ATOX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATOX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATOX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATOX1

    1 HMDB Compound for ATOX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--

    2 DrugBank Compounds for ATOX1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzamidine-- 618-39-3target--17139284 17016423 10592235
    Sucrose-- 57-50-1target----

    10/20 Novoseek chemical compound relationships for ATOX1 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    copper 88.7 341 14754885 (7), 20166696 (5), 10557326 (5), 10585777 (5) (see all 99)
    plastocyanin 72.9 3 16245081 (1), 17029824 (1), 18408011 (1)
    copper(i) 71.8 3 15670166 (2), 18093982 (1)
    bicinchoninic acid 60.7 4 8080090 (1), 8031990 (1)
    iron 49.4 10 10473283 (1), 11721763 (1), 15749739 (1), 16267389 (1) (see all 9)
    methylamine 44.7 1 8363574 (1)
    imidazole 42 2 10642183 (1), 19756283 (1)
    superoxide 37.2 7 16211579 (1), 18719950 (1), 19075668 (1), 15131305 (1)
    galactose 30.2 3 19946719 (1), 9602051 (1), 15573156 (1)
    zinc 30 6 10473283 (1), 12568924 (1), 1949156 (1), 17628094 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about ATOX1 

    Transcripts
    for ATOX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATOX1 gene: 
    NM_004045.3  

    Unigene Cluster for ATOX1:

    ATX1 antioxidant protein 1 homolog (yeast)
    Hs.125213  [show with all ESTs]
    Unigene Representative Sequence: AK128210
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521264 ENST00000520382 ENST00000522145 ENST00000522314 ENST00000524142(uc003luk.3)
    ENST00000522710 ENST00000313115

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ATOX1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATOX1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ATOX1 (see all 9):
    hsa-miR-137 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-133b hsa-miR-133a hsa-miR-363
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATOX1 (see all 7)
    OriGene shRNA RFP: ATOX1
    OriGene siRNA: ATOX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATOX1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATOX1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATOX1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ATOX1 (NM_004045)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATOX1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATOX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATOX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATOX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATOX1

    Additional cDNA sequence: 

    AK128210.1 AK293063.1 BC112248.1 BC112250.1 BT009786.1 CR456901.1 

    18 DOTS entries:

    DT.100799172  DT.95073073  DT.100059279  DT.120869052  DT.91897445  DT.97797010  DT.100811892  DT.95173046 
    DT.100034084  DT.100799165  DT.95173039  DT.100052985  DT.120868949  DT.120868991  DT.91742037  DT.91742041 
    DT.95173049  DT.99932873 

    24/199 AceView cDNA sequences (see all 199):

    AV690589 AI685336 AA932500 BT009786 AA953785 AA379880 AW953080 AA907001 
    AA318562 AA703181 BU607812 AK091843 AI268339 AA765974 BQ650173 AV703250 
    AA972377 AI492819 AI375822 BU071944 AI800936 AA379924 BM769150 CD107901 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ATOX1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                                            -     -               
    SP2:                          -                 -     -               
    SP3:                          -                 -     -               
    SP4:                          -                                       
    SP5:                          -     -           -     -               


    ECgene alternative splicing isoforms for ATOX1

    Expression
    for ATOX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATOX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCGGGTGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ATOX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeVentral Foregut EndodermGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ATOX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATOX1

    SOURCE GeneReport for Unigene cluster: Hs.125213

    UniProtKB/Swiss-Prot: ATOX1_HUMAN, O00244
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including ATOX1: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATOX1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATOX1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATOX1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATOX1
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ATOX1

    Orthologs
    for ATOX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ATOX1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Atox11 , 5 ATX1 (antioxidant protein 1) homolog 1 (yeast)1, 5 87.88(n)1
    87.88(a)1    		   11 (33.07 cM)5
    119271  NM_009720.21  NP_033850.11 
     554466415 
    chicken
    (Gallus gallus)    		 Aves ATOX11 ATX1 antioxidant protein 1 homolog (yeast) 75.76(n)
    77.27(a)    		   770231  XM_001233562.2  XP_001233563.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ATOX16
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL343248.1(15372-24091)
    zebrafish
    (Danio rerio)    		 Actinopterygii CR954266.16
    		 --
    		 70(a)
    		 1 ↔ 1
    		 14(26992519-26995224)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Atox16
    		 --
    		 49(a)
    		 1 ↔ 1
    		 3L(21634095-21635699)


    ENSEMBL Gene Tree for ATOX1 (if available)
    TreeFam Gene Tree for ATOX1 (if available) 

    Paralogs
    for ATOX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ATOX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/293 NCBI SNPs in ATOX1 are shown (see all 293)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs100459551,2
    		C,H,--151121890(+) TTTTTT/AAACCA 1 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs289172221,2
    		C,F,--151121996(-) ACCTCT/GCAGTG 1 -- ds50016Minor allele frequency- G:0.02NS WA 302
    rs1886817711,2
    		--151122085(+) CACTTA/GCTTAA 1 -- ds50010--------
    rs1417526391,2
    		--151122152(+) GTCTAC/TGAAAC 1 -- ds50010--------
    rs1117527491,2
    		C--151122382(+) AACATC/G/TTCCAA 1 -- ds50011CSA 1
    rs1501661391,2
    		--151122386(+) TCTCCA/GACAAA 1 -- ut310--------
    rs1811667521,2
    		--151122467(+) CACCCA/GGCATG 1 -- ut310--------
    rs1389314581,2
    		--151122662(+) TGAGGC/TGGAAA 1 -- int10--------
    rs765385751,2
    		F,--151122670(+) AAAACG/ACAGGG 1 -- int11Minor allele frequency- A:0.07WA 118
    rs1454330151,2
    		C,--151122826(+) TGCCA-/GGATAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ATOX1 (151121877 - 151152093 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ATOX1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATOX1
    DNA2.0 Custom Variant and Variant Library Synthesis for ATOX1

    Disorders / Diseases
    for ATOX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATOX1 for disorders           About GeneDecksing

    OMIM gene information: 602270    OMIM disorders: --

    7 diseases for ATOX1:    About MalaCards
    menkes disease    primary biliary cirrhosis    wilson disease    neurodegenerative disease
    huntington's disease    choriocarcinoma    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for ATOX1:
    Wilson disease     Menkes disease

    4 Novoseek disease relationships for ATOX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    menkes disease 85.7 4 15133031 (1), 17420847 (1), 15670166 (1), 17616150 (1)
    wilson disease 83.4 18 10557326 (3), 20166696 (2), 18416466 (2), 12763797 (1) (see all 9)
    inflammation 0 1 16267389 (1)
    neurodegenerative diseases 0 1 17420847 (1)

    Human Genome Epidemiology (HuGE) Navigator: ATOX1 (1 document)

    Export disorders for ATOX1 gene to outside databases

    Publications
    for ATOX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATOX1 gene, integrated from 9 sources (see all 169):
    (articles sorted by number of sources associating them with ATOX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis. (PubMed id 9083055)1, 2, 3, 9 Klomp L.W.J....Gitlin J.D. (1997)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genomic organization of ATOX1, a human copper chaperone. (PubMed id 12594858)1, 2 Liu P.-C.... Kaler S.G. (2003)
    5. Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins. (PubMed id 10966647)1, 2 Wernimont A.K....Rosenzweig A.C. (2000)
    6. Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. (PubMed id 10557326)1, 9 Hamza I....Gitlin J.D. (1999)
    7. Differential roles of Met10, Thr11, and Lys60 in structural dynamics of human copper chaperone Atox1. (PubMed id 19146392)1, 9 Rodriguez-Granillo A. and Wittung-Stafshede P. (2009)
    8. Role of antioxidant-1 in extracellular superoxide dismutase function and expression. (PubMed id 15761197)1, 9 Jeney V....Fukai T. (2005)
    9. Analysis of the human Atox 1 homologue in Wilson patients. (PubMed id 18416466)1, 9 Simon I....Stremmel W. (2008)
    10. Insights into Cu(I) exchange in HAH1 using quantum mechanical and molecular simulations. (PubMed id 17616150)1, 9 Op't Holt B.T. and Merz K.M. (2007)

    External Searches for ATOX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ATOX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 475 HGNC: 798 AceView: ATOX1 Ensembl:ENSG00000177556 euGenes: HUgn475
    ECgene: ATOX1 Kegg: 475 H-InvDB: ATOX1

    Other Databases showing ATOX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATOX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATOX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATOX1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/atox1/

    Intellectual Property
    for ATOX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATOX1 gene:
    Search GeneIP for patents involving ATOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ATOX1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ATOX1   OriGene shRNA RFP for ATOX1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATOX1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATOX1  
     OriGene Protein Over-expression Lysate for ATOX1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ATOX1   OriGene 3'-UTR Clone for ATOX1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATOX1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATOX1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATOX1   OriGene Custom Protein Services for ATOX1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATOX1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATOX1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATOX1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATOX1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATOX1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATOX1
     GenScript Custom Purified and Recombinant Proteins Services for ATOX1 GenScript cDNA clones with any tag delivered in your preferred vector for ATOX1
     GenScript Custom Assay Services for ATOX1 GenScript Custom Superior Antibodies Services for ATOX1
     GenScript Custom overexpressing Cell Line Services for ATOX1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ATOX1 promoter
     Search Chromatin IP Primers for ATOX1
     RT2 qPCR Primer Assay in human, mouse, rat ATOX1
     GNC Network for ATOX1
     SABiosciences PCR Arrays including human, mouse, rat ATOX1
     Search Tocris compounds for ATOX1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ATOX1 antibodies
     ATOX1 proteins
     ATOX1 lysates
     Antibodies for ATOX1
     See all of Abcam's Antibodies, Kits and Proteins for ATOX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ATOX1




     ATOX1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ATOX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ATOX1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ATOX1
     SwitchGear Promoter luciferase reporter plasmids for ATOX1
     ThermoFisher Antibodies for ATOX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATOX1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ATOX1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4