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ATOH8 Gene

protein-coding   GIFtS: 48
GCID: GC02P085978

Atonal Homolog 8 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Atonal Homolog 8 (Drosophila)1 2     Atonal Homolog 62
Basic Helix Loop Helix Transcription Factor 61 2     Basic Helix-Loop-Helix Transcription Factor 62
Class A Basic Helix-Loop-Helix Protein 212 3     Protein Atonal Homolog 82
Helix-Loop-Helix Protein HATH-62 3     ATH63
bHLHa212 3     BHLHA213
HATH62     hATH63

External Ids:    HGNC: 241261   Entrez Gene: 849132   Ensembl: ENSG000001688747   UniProtKB: Q96SQ73   

Export aliases for ATOH8 gene to outside databases

Previous GC identifers: GC00U913743 GC02P085956 GC02P085892


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATOH8 Gene:
ATOH8 (atonal homolog 8 (Drosophila)) is a protein-coding gene. Diseases associated with ATOH8 include endotheliitis, and thyroiditis. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot: ATOH8_HUMAN, Q96SQ7
Function: Putative transcription factor. May be implicated in specification and differentiation of neuronal cell
lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATOH8 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   N-Myc   AREB6   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATOH8 promoter sequence
   Search Chromatin IP Primers for ATOH8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATOH8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

ATOH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATOH8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P085978:  view genomic region     (about GC identifiers)

Start:
85,978,467 bp from pter      End:
86,018,506 bp from pter
Size:
40,040 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATOH8_HUMAN, Q96SQ7 (See protein sequence)
Recommended Name: Protein atonal homolog 8  
Size: 321 amino acids; 34644 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Secondary accessions: Q504S2 Q659B0
Alternative splicing: 2 isoforms:  Q96SQ7-1   Q96SQ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATOH8: NX_Q96SQ7

Explore proteomics data for ATOH8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ATOH8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116216.2  
    ENSEMBL proteins: 
     ENSP00000304676  

    ATOH8 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q96SQ7

    ProtoNet protein and cluster: Q96SQ7

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: ATOH8_HUMAN, Q96SQ7
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    ATOH8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATOH8_HUMAN, Q96SQ7
    Function: Putative transcription factor. May be implicated in specification and differentiation of neuronal cell
    lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046983protein dimerization activity IEA--
         
    ATOH8 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ATOH8:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Atoh8):
     cardiovascular system  mortality/aging  respiratory system 

    ATOH8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ATOH8: Atoh8tm2.1Mlkn Atoh8tm1.1Mlkn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATOH8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATOH8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATOH8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATOH8

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATOH8:
    hsa-mir-193b-3p (MIRT016345), hsa-mir-124-3p (MIRT022278)

    Block miRNA regulation of human, mouse, rat ATOH8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATOH8 (see all 52):
    hsa-miR-193a-3p hsa-miR-1321 hsa-miR-106a hsa-miR-650 hsa-miR-183* hsa-miR-9 hsa-miR-1184 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidATOH8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATOH8
    Predesigned siRNA for gene silencing in human, mouse, rat ATOH8

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATOH8 (NM_032827)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATOH8

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATOH8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATOH8_HUMAN, Q96SQ7: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ATOH8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATOH8
    Interactions:

        Search GeneGlobe Interaction Network for ATOH8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ATOH8 (ENSP000003046764) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NF2ENSP000003446664STRING: ENSP00000344666
    NLKENSP000003846254STRING: ENSP00000384625
    TCF3ENSP000002629654STRING: ENSP00000262965
    ID2ENSP000002340914STRING: ENSP00000234091
    RHBDL1ENSP000002195514STRING: ENSP00000219551
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--

    ATOH8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATOH8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATOH8 gene: 
    NM_032827.6  

    Unigene Cluster for ATOH8:

    Atonal homolog 8 (Drosophila)
    Hs.135569  [show with all ESTs]
    Unigene Representative Sequence: NM_032827
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469442 ENST00000306279(uc002sqn.3) ENST00000463422(uc002sqm.4)
    ENST00000473116 ENST00000489682
    miRNA
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    Block miRNA regulation of human, mouse, rat ATOH8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATOH8 (see all 52):
    hsa-miR-193a-3p hsa-miR-1321 hsa-miR-106a hsa-miR-650 hsa-miR-183* hsa-miR-9 hsa-miR-1184 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidATOH8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ATOH8
    Predesigned siRNA for gene silencing in human, mouse, rat ATOH8
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    OriGene ORF clones in mouse, rat for ATOH8
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    GenScript: all cDNA clones in your preferred vector: ATOH8 (NM_032827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATOH8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATOH8
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ATOH8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATOH8
      QuantiTect SYBR Green Assays in human, mouse, rat ATOH8
      QuantiFast Probe-based Assays in human, mouse, rat ATOH8

    Additional mRNA sequence: 

    AF529205.1 AK027614.1 AK074681.1 AK093766.1 AK096049.1 AL831857.1 BC019854.1 BC021207.2 
    BC094832.1 CR749611.1 

    8 DOTS entries:

    DT.437368  DT.97801441  DT.100754792  DT.40228703  DT.97828799  DT.95365510  DT.403349  DT.95365508 

    Selected AceView cDNA sequences (see all 84):

    AK027614 BM770138 BG057085 CD516709 AI361517 BM709971 CA396816 BE393045 
    AK074681 AL831857 BX115320 BF725177 BG820302 BM756548 CF132508 CR625589 
    BQ067527 CD672386 BM756547 CA390309 AK093766 CB242753 BI819661 AF529205 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATOH8 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
    SP1:                                -                                                   
    SP2:              -     -           -     -     -     -     -                           
    SP3:        -     -     -           -     -     -     -     -                           
    SP4:                                -     -     -     -     -                           
    SP5:                                      -     -     -     -                           


    ECgene alternative splicing isoforms for ATOH8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATOH8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGAAAAA
    ATOH8 Expression
    About this image


    ATOH8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    ATOH8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATOH8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.135569

    UniProtKB/Swiss-Prot: ATOH8_HUMAN, Q96SQ7
    Tissue specificity: Expressed in lung, liver, kidney, heart and pancreas. Expressed in endothel of umbilical
    vessels

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATOH8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATOH8 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atoh81 , 5 atonal homolog 8 (Drosophila)1, 5 85.97(n)1
    86.39(a)1
      6 (32.27 cM)5
    710931  NM_153778.31  NP_722473.11 
     722061775 
    lizard
    (Anolis carolinensis)
    Reptilia ATOH86
    atonal homolog 8 (Drosophila)
    90(a)
    1 ↔ 1
    GL343395.1(872168-899883)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atoh81 atonal homolog 8 (Drosophila) 72.26(n)
    79.56(a)
      100490889  XM_002937284.2  XP_002937330.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.221502 Transcribed sequence with weak similarity to protein more 80.12(n)    CK139056.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta net6
    net
    23(a)
    1 ↔ 1
    2L(82421-87387)


    ENSEMBL Gene Tree for ATOH8 (if available)
    TreeFam Gene Tree for ATOH8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATOH8 (see all 815)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428345061,2
    --85978982(+) GAGGCA/TATGGT 1 -- us2k10--------
    rs760420161,2
    F--85979002(+) AGGTTC/TGCGGG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1510092791,2
    C--85979012(+) GAGGAA/GGGGGA 1 -- us2k10--------
    rs75678521,2
    C,F,H--85979027(+) AGCTGG/TTCATC 1 -- us2k112Minor allele frequency- T:0.16WA NA CSA EA 378
    rs1871948201,2
    --85979028(+) GCTGTG/TCATCG 1 -- us2k10--------
    rs1396427751,2
    --85979036(+) TCGAAC/GGGTGA 1 -- us2k10--------
    rs1497145051,2
    --85979059(+) GTTGCA/CAAGGG 1 -- us2k10--------
    rs1908786781,2
    --85979134(+) CAGGAC/GAATGA 1 -- us2k10--------
    rs1467151441,2
    --85979151(+) CTCTTC/TGGCAG 1 -- us2k10--------
    rs1403515761,2
    --85979292(+) ACTATA/GTTCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATOH8 (85978467 - 86018506 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ATOH8:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4204n71CNV Loss21882294
    nsv874468CNV Loss21882294
    nsv829487CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATOH8
    DNA2.0 Custom Variant and Variant Library Synthesis for ATOH8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for ATOH8:    
    About MalaCards
    endotheliitis    thyroiditis    neuronitis


    ATOH8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATOH8
    Human Genome Epidemiology (HuGE) Navigator: ATOH8 (3 documents)

    Export disorders for ATOH8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATOH8 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ATOH8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene expression profile of human endothelial cells exposed to sustained fluid shear stress. (PubMed id 12419857)1, 2, 3 Wasserman S.M.... Topper J.N. (Physiol. Genomics 2002)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (Mol. Cell. Biol. 2012)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor. (PubMed id 21857980)1 Chen J....Brand-Saberi B. (PLoS ONE 2011)
    7. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84913 HGNC: 24126 AceView: ATOH8 Ensembl:ENSG00000168874 euGenes: HUgn84913
    ECgene: ATOH8 H-InvDB: ATOH8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATOH8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATOH8 gene:
    Search GeneIP for patents involving ATOH8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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