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Aliases for ATOH8 Gene

Aliases for ATOH8 Gene

  • Atonal Homolog 8 (Drosophila) 2 3
  • Basic Helix Loop Helix Transcription Factor 6 2 3
  • Class A Basic Helix-Loop-Helix Protein 21 3 4
  • Helix-Loop-Helix Protein HATH-6 3 4
  • BHLHa21 3 4
  • HATH6 3 4
  • Basic Helix-Loop-Helix Transcription Factor 6 3
  • Protein Atonal Homolog 8 3
  • Atonal Homolog 6 3
  • ATH6 4

External Ids for ATOH8 Gene

Previous GeneCards Identifiers for ATOH8 Gene

  • GC00U913743
  • GC02P085956
  • GC02P085892
  • GC02P085978

Summaries for ATOH8 Gene

GeneCards Summary for ATOH8 Gene

ATOH8 (Atonal Homolog 8 (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity.

UniProtKB/Swiss-Prot for ATOH8 Gene

  • Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATOH8 Gene

Genomics for ATOH8 Gene

Regulatory Elements for ATOH8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATOH8 Gene

Start:
85,751,344 bp from pter
End:
85,791,383 bp from pter
Size:
40,040 bases
Orientation:
Plus strand

Genomic View for ATOH8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATOH8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATOH8 Gene

Proteins for ATOH8 Gene

  • Protein details for ATOH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SQ7-ATOH8_HUMAN
    Recommended name:
    Protein atonal homolog 8
    Protein Accession:
    Q96SQ7
    Secondary Accessions:
    • Q504S2
    • Q659B0

    Protein attributes for ATOH8 Gene

    Size:
    321 amino acids
    Molecular mass:
    34644 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

    Alternative splice isoforms for ATOH8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATOH8 Gene

Proteomics data for ATOH8 Gene at MOPED

Post-translational modifications for ATOH8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATOH8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ATOH8 Gene

Domains for ATOH8 Gene

Gene Families for ATOH8 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Protein Domains for ATOH8 Gene

Suggested Antigen Peptide Sequences for ATOH8 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SQ7

UniProtKB/Swiss-Prot:

ATOH8_HUMAN :
  • Q96SQ7
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ATOH8: view

Function for ATOH8 Gene

Molecular function for ATOH8 Gene

UniProtKB/Swiss-Prot Function: Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for ATOH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ATOH8: view
genes like me logo Genes that share phenotypes with ATOH8: view

Animal Models for ATOH8 Gene

MGI Knock Outs for ATOH8:

Animal Model Products

CRISPR Products

miRNA for ATOH8 Gene

miRTarBase miRNAs that target ATOH8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATOH8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ATOH8 Gene

Localization for ATOH8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATOH8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATOH8 Gene COMPARTMENTS Subcellular localization image for ATOH8 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ATOH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ATOH8: view

Pathways for ATOH8 Gene

SuperPathways for ATOH8 Gene

No Data Available

Interacting Proteins for ATOH8 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304676%0d%0a9606.ENSP00000262965%0d%0a9606.ENSP00000222982%0d%0a
Selected Interacting proteins: ENSP00000304676 for ATOH8 Gene via STRING

Gene Ontology (GO) - Biological Process for ATOH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ATOH8: view

No data available for Pathways by source for ATOH8 Gene

Transcripts for ATOH8 Gene

Unigene Clusters for ATOH8 Gene

Atonal homolog 8 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATOH8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATOH8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATOH8 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
SP1: -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6:

Relevant External Links for ATOH8 Gene

GeneLoc Exon Structure for
ATOH8
ECgene alternative splicing isoforms for
ATOH8

Expression for ATOH8 Gene

mRNA expression in normal human tissues for ATOH8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ATOH8 Gene Hs.135569

mRNA Expression by UniProt/SwissProt for ATOH8 Gene

Q96SQ7-ATOH8_HUMAN
Tissue specificity: Expressed in lung, liver, kidney, heart and pancreas. Expressed in endothel of umbilical vessels.
genes like me logo Genes that share expressions with ATOH8: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein expression for ATOH8 Gene

Orthologs for ATOH8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATOH8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATOH8 35
  • 93.8 (n)
  • 92.25 (a)
ATOH8 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATOH8 35
  • 89.98 (n)
  • 91.14 (a)
ATOH8 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATOH8 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atoh8 35
  • 85.97 (n)
  • 86.39 (a)
Atoh8 16
Atoh8 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATOH8 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATOH8 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atoh8 35
  • 86.39 (n)
  • 86.08 (a)
lizard
(Anolis carolinensis)
Reptilia ATOH8 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atoh8 35
  • 72.26 (n)
  • 79.56 (a)
zebrafish
(Danio rerio)
Actinopterygii atoh8 36
  • 47 (a)
OneToOne
Dr.22150 35
fruit fly
(Drosophila melanogaster)
Insecta net 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToOne
Species with no ortholog for ATOH8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATOH8 Gene

ENSEMBL:
Gene Tree for ATOH8 (if available)
TreeFam:
Gene Tree for ATOH8 (if available)

Paralogs for ATOH8 Gene

No data available for Paralogs for ATOH8 Gene

Variants for ATOH8 Gene

Sequence variations from dbSNP and Humsavar for ATOH8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs727123 -- 85,791,310(-) AAAGC(C/T)GTTTC utr-variant-3-prime
rs734042 -- 85,787,973(-) AGGGG(C/T)GGGCC utr-variant-3-prime
rs736991 -- 85,787,222(+) GGGTG(A/G)TGAAA utr-variant-3-prime
rs748064 -- 85,789,199(-) GGGAT(A/G)GGAGG utr-variant-3-prime
rs750442 -- 85,785,762(-) CATTC(C/T)CATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATOH8 Gene

Variant ID Type Subtype PubMed ID
nsv874468 CNV Loss 21882294
dgv4204n71 CNV Loss 21882294
nsv829487 CNV Gain 20364138

Relevant External Links for ATOH8 Gene

HapMap Linkage Disequilibrium report
ATOH8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATOH8 Gene

Disorders for ATOH8 Gene

Relevant External Links for ATOH8

Genetic Association Database (GAD)
ATOH8
Human Genome Epidemiology (HuGE) Navigator
ATOH8
genes like me logo Genes that share disorders with ATOH8: view

No data available for UniProtKB/Swiss-Prot for ATOH8 Gene

Publications for ATOH8 Gene

  1. Gene expression profile of human endothelial cells exposed to sustained fluid shear stress. (PMID: 12419857) Wasserman S.M. … Topper J.N. (Physiol. Genomics 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor. (PMID: 21857980) Chen J. … Brand-Saberi B. (PLoS ONE 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ATOH8 Gene

Sources for ATOH8 Gene

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