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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATOH7 Gene

protein-coding GIFtS: 50
GCID: GC10M069990

atonal homolog 7 (Drosophila)

Explore 5 diseases affiliated with
ATOH7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Atonal Homolog 7 (Drosophila)¹ ²		Protein Atonal Homolog 7²
BHLHa13¹		ATH5³
Math5¹ ²		BHLHA13³
Class A Basic Helix-Loop-Helix Protein 13² ³		HATH5¹
Helix-Loop-Helix Protein HATH-5² ³

External Ids:	HGNC: 13907¹	Entrez Gene: 220202²	Ensembl: ENSG00000179774⁷	OMIM: 609875⁵	UniProtKB: Q8N100³

Export aliases for ATOH7 gene to outside databases

Previous GC identifers: GC10M068802 GC10M069077 GC10M069882 GC10M069335 GC10M069334 GC10M069660 GC10M063990

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATOH7:

This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to

Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central

role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic

congenital retinal nonattachment. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: ATOH7_HUMAN, Q8N100

Function: Transcription factor involved in the differentiation of retinal ganglion cells (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATOH7 gene promoter:
USF1 RP58 NF-E2 p45 Tal-1beta SRY HOXA5 ITF-2 NF-E2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATOH7 promoter sequence

Search SABiosciences Chromatin IP Primers for ATOH7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATOH7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3|10q21.3-q22.1 Ensembl cytogenetic band: 10q21.3 HGNC cytogenetic band: 10q22.2

ATOH7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATOH7 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M069990: view genomic region (about GC identifiers)

Start:	69,990,381 bp from pter	End:	69,991,871 bp from pter
Size:	1,491 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATOH7_HUMAN, Q8N100 (See protein sequence)

Recommended Name: Protein atonal homolog 7

Size: 152 amino acids; 16871 Da

Subcellular location: Nucleus (Probable)

Explore the universe of human proteins at neXtProt for ATOH7: NX_Q8N100

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N100

ATOH7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_660161.1

ENSEMBL proteins:

ENSP00000362777

Human Recombinant Protein Products:

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	Novus Biologicals ATOH7 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ATOH7

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

ATOH7 for ontologies About GeneDecksing

ATOH7 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ATOH7
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	Uscn Antibodies for ATOH7
	Search ThermoFisher Antibodies for ATOH7

Assay Products for ATOH7:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ATOH7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATOH7 for domains About GeneDecksing

1 InterPro domain/family:

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry Q8N100

ProtoNet protein and cluster: Q8N100

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: ATOH7_HUMAN, Q8N100

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ATOH7_HUMAN, Q8N100

Function: Transcription factor involved in the differentiation of retinal ganglion cells (By similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATOH7
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ATOH7:
		hsa-miR-3658 hsa-miR-1283 hsa-miR-561 hsa-miR-3921 hsa-miR-1224-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ATOH7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATOH7 (see all 4) OriGene shRNA RFP: ATOH7 OriGene siRNA: ATOH7
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ATOH7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATOH7 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATOH7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ATOH7 (NM_145178)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATOH7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATOH7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ATOH7
		Search LifeMap BioReagents cell lines for ATOH7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATOH7

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

ATOH7 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ATOH7:

Increased gamma-H2AX phosphory

Animal Models:
7 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Atoh7):

behavior/neurological	cardiovascular system	cellular	nervous system	normal
reproductive system	vision/eye

ATOH7 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription factors in neurogenesis

Transcription factors in neurogenesis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ATOH7

Transcription factors in neurogenesis

ATOH7 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ATOH7

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007399	nervous system development	IEA	--
GO:0007623	circadian rhythm	IEA	--
GO:0009649	entrainment of circadian clock	IEA	--

ATOH7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ATOH7
Search CenterWatch for drugs/clinical trials and news about ATOH7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATOH7 gene:

NM_145178.3

Unigene Cluster for ATOH7:

Atonal homolog 7 (Drosophila)

Hs.737072 [show with all ESTs]

Unigene Representative Sequence: NM_145178

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000373673(uc001jnq.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATOH7
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ATOH7:
		hsa-miR-3658 hsa-miR-1283 hsa-miR-561 hsa-miR-3921 hsa-miR-1224-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ATOH7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATOH7 (see all 4) OriGene shRNA RFP: ATOH7 OriGene siRNA: ATOH7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATOH7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATOH7 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATOH7 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ATOH7 (NM_145178)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATOH7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATOH7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATOH7 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATOH7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATOH7

Additional cDNA sequence:

AB593108.1 AB593109.1 BC032621.1

1 DOTS entry:

DT.97784371

7 AceView cDNA sequences:

NM_145178 BK000277 BM474709 BC032621 AI799665 H05728 BU151599

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATOH7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTATCGGTG

About this image

ATOH7 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Ganglion Cell Layer

Ganglion Precursor Cells

Selective marker (cell-identifying gene)

Ganglion, Retina

Eye

Neuroblastic Layer

Early Retinal Progenitor Cells

Retina

Eye

Neuroblastic Layer

Late Retinal Progenitor Cells

Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Retinal progenitor-like cells (Generation of retina...)

See ATOH7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATOH7

SOURCE GeneReport for Unigene cluster: Hs.737072

SABiosciences Custom PCR Arrays for ATOH7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATOH7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ATOH7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATOH7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATOH7

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATOH7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ATOH7 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ATOH7¹	atonal homolog 7 (Drosophila)	62.44(n) 64(a)		395388 NM_204668.1 NP_989999.1
lizard (Anolis carolinensis)	Reptilia	ATOH7⁶	--	60(a)	1 ↔ 1	GL343215.1(1447009-1447458)
African clawed frog (Xenopus laevis)	Amphibia	atoh5b-A²	atonal homolog 5b	74.68(n)		U93171.1
zebrafish (Danio rerio)	Actinopterygii	atoh7²	atonal homolog 7	82.39(n)		58216 AB049457.1
fruit fly (Drosophila melanogaster)	Insecta	cato⁶ amos⁶ (see all 3)	absent MD neurons and olfactory sensilla (see all 3)	22(a) 21(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2R(12165294-12165902) 2L(18596047-18597200)
worm (Caenorhabditis elegans)	Secernentea	lin-32⁶	Protein lin-32	26(a)	1 → many	X(2229116-2230094)

ENSEMBL Gene Tree for ATOH7 (if available)
TreeFam Gene Tree for ATOH7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ATOH7 gene

NEUROG3² FERD3L² NEUROD2² NEUROD1² NEUROD6² ATOH1² NEUROG2² BHLHA15²

PTF1A² NEUROG1² NEUROD4²

8 SIMAP similar genes for ATOH7 using alignment to 2 protein entries: ATOH7_HUMAN (see all proteins):

ATOH1 TAL2 NEUROD2 NEUROD6 NEUROD4 TCF15

SCXA SCXB

ATOH7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73269166^1,2	C,	--	63989927(+)	`AGGAAC/GTACTA`	1	--	ds500¹		2		WA	120
rs73269167^1,2	C,	--	63990390(+)	`TCCCTC/GAAAGT`	1	--	ut3¹		2		WA	120
rs6480319^1,2	C,A,	--	63991324(+)	`TCTACT/CGGATG`	1	--	ut5¹ ese³		2		CSA WA	120
rs6480320^1,2	C,F,A,H,	--	63991373(+)	`AAAATG/AANNNN`	1	--	ut5¹		13		NS EA NA WA CSA	1484
rs73269175^1,2	C,	--	63992474(+)	`TTCAGT/ATGTGT`	1	--	us2k¹		2		WA	120
rs78295529^1,2	F,	--	63992775(+)	`TAACCG/ATGACT`	1	--	us2k¹		1		EA	120
rs73269177^1,2	C,	--	63992946(+)	`TCTCCA/CGCATG`	1	--	us2k¹		2		WA	120
rs72795459^1,2	C,	--	63993348(+)	`AAATAC/TTACTG`	1	--	us2k¹		0	--	--	--	--
rs187610494^1,2		--	69989852(+)	`TTGCTC/TCCATT`	1	--	ds500¹		0	--	--	--	--
rs114692316^1,2	F,	--	69989949(+)	`TTCTGT/GGTTAG`	1	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for ATOH7 (69990381 - 69991871 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATOH7: --
Human Gene Mutation Database (HGMD): ATOH7

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATOH7

DNA2.0 Custom Variant and Variant Library Synthesis for ATOH7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ATOH7 for disorders About GeneDecksing

OMIM gene information: 609875 OMIM disorders: --

UniProtKB/Swiss-Prot: ATOH7_HUMAN, Q8N100

Defects in ATOH7 are the cause of retinal non-attachment congenital non-syndromic (RNANC) [MIM:221900]. A

condition characterized by separation of the inner layers of the retina (neural retina) from the pigment epithelium.

Clinical findings include lack of perception of light, massive retrolental mass, shallow anterior chamber, and

nystagmus in otherwise normal individuals. Note=RNANC is caused by a 6.5 kb deletion that spans a remote cis

regulatory element 20 kb upstream from ATOH7

5 diseases for ATOH7: About MalaCards

retinal nonattachment retinitis nystagmus glaucoma

neuronitis

1 disease from the University of Copenhagen DISEASES database for ATOH7:

Glaucoma

Human Genome Epidemiology (HuGE) Navigator: ATOH7 (4 documents)

Export disorders for ATOH7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ATOH7 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ATOH7)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. (PubMed id 11889557)^{1, 2, 3, 9} Brown N.L.... Glaser T. (2002)
Deletion of a remote enhancer near ATOH7 disrupts ret inal neurogenesis, causing NCRNA disease. (PubMed id 21441919)^{1, 2} Ghiasvand N.M....Glaser T. (2011)
Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)^{1, 2} McLellan A.S.... Kealey T. (2002)
Next generation sequencing identifies mutations in Ato nal homolog 7 (ATOH7) in families with global eye developmental defects. (PubMed id 22068589)¹ Khan K....Ali M. (2012)
Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma. (PubMed id 22222511)¹ Chen J.H....Zhang M. (2012)
ATOH7 mutations cause autosomal recessive persistent h yperplasia of the primary vitreous. (PubMed id 22645276)¹ Prasov L....Glaser T. (2012)
Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)¹ Oshikawa M.... Kato S. (2011)
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. (PubMed id 21307088)¹ Khor C.C....Aung T. (2011)
Common genetic variants associated with open-angle gl aucoma. (PubMed id 21427129)¹ Ramdas W.D....van Duijn C.M. (2011)
Focus on Molecules: Math5 and retinal ganglion cells. (PubMed id 22019371)¹ Sapkota D....Mu X. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 220202	HGNC: 13907	AceView: ATOH7	Ensembl:ENSG00000179774	euGenes: HUgn220202
ECgene: ATOH7	H-InvDB: ATOH7

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ATOH7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ATOH7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ATOH7 gene:
Search GeneIP for patents involving ATOH7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATOH7
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	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATOH7
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATOH7
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	GenScript Custom Purified and Recombinant Proteins Services for ATOH7		GenScript cDNA clones with any tag delivered in your preferred vector for ATOH7
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATOH7

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATOH7

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ATOH7 gene at Home site.

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ATOH7 Gene

atonal homolog 7 (Drosophila)

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for ATOH7 gene

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for ATOH7 gene

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for ATOH7 gene

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for ATOH7 gene

Protein Domains /
Families
for ATOH7 gene

Function
for ATOH7 gene

Pathways & Interactions
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Transcripts
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ATOH7 Gene

atonal homolog 7 (Drosophila)

Aliasesfor ATOH7 gene

Summariesfor ATOH7 gene

Genomic Viewsfor ATOH7 gene

Proteinsfor ATOH7 gene

Protein Domains /Familiesfor ATOH7 gene

Functionfor ATOH7 gene

Pathways & Interactionsfor ATOH7 gene

Drugs & Compoundsfor ATOH7 gene

Transcriptsfor ATOH7 gene

Expression for ATOH7 gene

Orthologsfor ATOH7 gene

Paralogsfor ATOH7 gene

Genomic Variantsfor ATOH7 gene

Disorders / Diseasesfor ATOH7 gene

Publicationsfor ATOH7 gene

External Searches for ATOH7 gene

Genome Databases showing ATOH7 gene

Other Databases showing ATOH7 gene

Specialized Databases showing ATOH7 gene

Intellectual Propertyfor ATOH7 gene

Productsfor ATOH7 gene

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Aliases
for ATOH7 gene

Summaries
for ATOH7 gene

Genomic Views
for ATOH7 gene

Proteins
for ATOH7 gene

Protein Domains /
Families
for ATOH7 gene

Function
for ATOH7 gene

Pathways & Interactions
for ATOH7 gene

Drugs & Compounds
for ATOH7 gene

Transcripts
for ATOH7 gene

Expression
for ATOH7 gene

Orthologs
for ATOH7 gene

Paralogs
for ATOH7 gene

Genomic Variants
for ATOH7 gene

Disorders / Diseases
for ATOH7 gene

Publications
for ATOH7 gene

Intellectual Property
for ATOH7 gene

Products
for ATOH7 gene