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Aliases for ATOH1 Gene

Aliases for ATOH1 Gene

  • Atonal BHLH Transcription Factor 1 2 3 5
  • Atonal Homolog BHLH Transcription Factor 1 2 3
  • Class A Basic Helix-Loop-Helix Protein 14 3 4
  • Helix-Loop-Helix Protein HATH-1 3 4
  • BHLHa14 3 4
  • HATH1 3 4
  • ATH1 3 4
  • Atonal Homolog 1 (Drosophila) 2
  • Atonal Homolog 1 3
  • MATH-1 3

External Ids for ATOH1 Gene

Previous GeneCards Identifiers for ATOH1 Gene

  • GC04P094907
  • GC04P095051
  • GC04P095208
  • GC04P095107
  • GC04P094750
  • GC04P090487

Summaries for ATOH1 Gene

Entrez Gene Summary for ATOH1 Gene

  • This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATOH1 Gene

ATOH1 (Atonal BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with ATOH1 include goblet cell carcinoid and infratentorial cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is NEUROG1.

UniProtKB/Swiss-Prot for ATOH1 Gene

  • Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).

Gene Wiki entry for ATOH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATOH1 Gene

Genomics for ATOH1 Gene

Regulatory Elements for ATOH1 Gene

Genomic Location for ATOH1 Gene

Chromosome:
4
Start:
93,828,753 bp from pter
End:
93,830,964 bp from pter
Size:
2,212 bases
Orientation:
Plus strand

Genomic View for ATOH1 Gene

Genes around ATOH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATOH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATOH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATOH1 Gene

Proteins for ATOH1 Gene

  • Protein details for ATOH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92858-ATOH1_HUMAN
    Recommended name:
    Protein atonal homolog 1
    Protein Accession:
    Q92858
    Secondary Accessions:
    • Q14CT9

    Protein attributes for ATOH1 Gene

    Size:
    354 amino acids
    Molecular mass:
    38160 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for ATOH1 Gene

Proteomics data for ATOH1 Gene at MOPED

Post-translational modifications for ATOH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATOH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ATOH1 Gene

Domains & Families for ATOH1 Gene

Gene Families for ATOH1 Gene

Protein Domains for ATOH1 Gene

Suggested Antigen Peptide Sequences for ATOH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92858

UniProtKB/Swiss-Prot:

ATOH1_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ATOH1: view

Function for ATOH1 Gene

Molecular function for ATOH1 Gene

GENATLAS Biochemistry:
Drosophila atonal proneural gene homolog,involved in the development of nervous system
UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).

Gene Ontology (GO) - Molecular Function for ATOH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0031490 chromatin DNA binding IEA --
genes like me logo Genes that share ontologies with ATOH1: view
genes like me logo Genes that share phenotypes with ATOH1: view

Animal Models for ATOH1 Gene

MGI Knock Outs for ATOH1:

Animal Model Products

miRNA for ATOH1 Gene

miRTarBase miRNAs that target ATOH1
Targeted motifs for ATOH1 Gene
HOMER Transcription Factor Regulatory Elements motif ATOH1
  • Consensus sequence: VNAVCAGCTGGC Submotif: canonical Cell Type: Cerebellum GEO ID: GSE22111

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ATOH1 Gene

Localization for ATOH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATOH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATOH1 Gene COMPARTMENTS Subcellular localization image for ATOH1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ATOH1 Gene

Pathways & Interactions for ATOH1 Gene

SuperPathways for ATOH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATOH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0007420 brain development IEA --
GO:0021987 cerebral cortex development IEA --
GO:0030154 cell differentiation IEA --
GO:0030182 neuron differentiation IEA --
genes like me logo Genes that share ontologies with ATOH1: view

No data available for Pathways by source and SIGNOR curated interactions for ATOH1 Gene

Drugs & Compounds for ATOH1 Gene

No Compound Related Data Available

Transcripts for ATOH1 Gene

mRNA/cDNA for ATOH1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATOH1 Gene

Atonal homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATOH1 Gene

No ASD Table

Relevant External Links for ATOH1 Gene

GeneLoc Exon Structure for
ATOH1
ECgene alternative splicing isoforms for
ATOH1

Expression for ATOH1 Gene

mRNA expression in normal human tissues for ATOH1 Gene

mRNA differential expression in normal tissues according to GTEx for ATOH1 Gene

This gene is overexpressed in Colon - Transverse (x32.4) and Small Intestine - Terminal Ileum (x17.9).

Protein differential expression in normal tissues from HIPED for ATOH1 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATOH1 Gene



SOURCE GeneReport for Unigene cluster for ATOH1 Gene Hs.532680

genes like me logo Genes that share expression patterns with ATOH1: view

Protein tissue co-expression partners for ATOH1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ATOH1 Gene

Orthologs for ATOH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATOH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATOH1 35
  • 88.64 (n)
  • 92.33 (a)
ATOH1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATOH1 35
  • 89.02 (n)
  • 90.06 (a)
ATOH1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atoh1 35
  • 84.62 (n)
  • 87.18 (a)
Atoh1 16
Atoh1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATOH1 35
  • 99.15 (n)
  • 98.59 (a)
ATOH1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atoh1 35
  • 84.81 (n)
  • 87.46 (a)
oppossum
(Monodelphis domestica)
Mammalia ATOH1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATOH1 35
  • 61.64 (n)
  • 54.76 (a)
lizard
(Anolis carolinensis)
Reptilia ATOH1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atoh1 35
  • 65.44 (n)
  • 64.34 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
atoh1a 35
  • 62.1 (n)
  • 57.68 (a)
atoh1a 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ato 36
  • 20 (a)
OneToOne
Species with no ortholog for ATOH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATOH1 Gene

ENSEMBL:
Gene Tree for ATOH1 (if available)
TreeFam:
Gene Tree for ATOH1 (if available)

Paralogs for ATOH1 Gene

(3) SIMAP similar genes for ATOH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATOH1: view

Variants for ATOH1 Gene

Sequence variations from dbSNP and Humsavar for ATOH1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs35182771 - 93,829,637(+) CACCA(A/C/T)CTTCG reference, missense
rs10009502 -- 93,828,907(+) TGAGC(C/G)TCCGA upstream-variant-2KB
rs11312657 -- 93,828,547(+) GAAGG(-/A)AAAAA upstream-variant-2KB
rs10015253 -- 93,827,138(+) CATTC(C/T)GTATC upstream-variant-2KB
rs34477680 -- 93,829,373(+) CTTCC(-/A)AGCAA reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for ATOH1 Gene

Variant ID Type Subtype PubMed ID
nsv821636 CNV Gain 15273396

Variation tolerance for ATOH1 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATOH1 Gene

HapMap Linkage Disequilibrium report
ATOH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATOH1 Gene

Disorders for ATOH1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ATOH1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
goblet cell carcinoid
  • gcc
infratentorial cancer
  • brain neoplasm, infratentorial
cerebellar liponeurocytoma
  • central neurocytoma
- elite association - COSMIC cancer census association via MalaCards
Search ATOH1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATOH1

Genetic Association Database (GAD)
ATOH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATOH1
genes like me logo Genes that share disorders with ATOH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATOH1 Gene

Publications for ATOH1 Gene

  1. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. (PMID: 8872459) Ben-Arie N. … Zoghbi H.Y. (Hum. Mol. Genet. 1996) 2 3 4 67
  2. Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. (PMID: 18275842) Aragaki M. … Watanabe M. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. (PMID: 17549667) Westerman B.A. … Oudejans C.B. (Int. J. Biol. Markers 2007) 3 23
  4. The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1. (PMID: 16831200) Mutoh H. … Sugano K. (Differentiation 2006) 3 23
  5. A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma. (PMID: 16382053) Leow C.C. … Gao W.Q. (Ann. N. Y. Acad. Sci. 2005) 3 23

Products for ATOH1 Gene

Sources for ATOH1 Gene

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