ATOH1 Gene
protein-coding GIFtS : 55
GCID: GC04 P094750
atonal homolog 1 (Drosophila)
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Aliasesfor ATOH1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Atonal Homolog 1 (Drosophila) 1 2 Helix-Loop-Helix Protein HATH-12 3 BHLHa141 Math11 ATH12 3 5 Protein Atonal Homolog 12 HATH11 2 BHLHA143 MATH-11 2 HATH11 2 Class A Basic Helix-Loop-Helix Protein 142 3
Export aliases for ATOH1 gene to outside databases Previous GC identifers: GC04P094907 GC04P095051 GC04P095208 GC04P095107 GC04P090487
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Summariesfor ATOH1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ATOH1 : This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ATOH1_HUMAN, Q92858 Function : Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but theactivity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity) Gene Wiki entry for ATOH1
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Genomic Viewsfor ATOH1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ATOH1 gene promoter: SRF p53 NCX/Ncx SRF (504 AA) FOXO3 Nkx2-5 FOXO3b SRY STAT3 FOXO3a Other transcription factors Search SABiosciences Chromatin IP Primers for ATOH1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ATOH1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q22 Ensembl cytogenetic band: 4q22.2 HGNC cytogenetic band: 4q22 ATOH1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P094750: view genomic region
(about GC identifiers )
Start:
94,750,042 bp from pter
End:
94,751,221 bp from pter
Size:
1,180 bases
Orientation:
plus strand
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Proteinsfor ATOH1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ATOH1_HUMAN, Q92858 (See
protein sequence )Recommended Name: Protein atonal homolog 1 Size : 354 amino acids; 38160 Da
Subunit : Efficient DNA binding requires dimerization with another bHLH protein
Subcellular location : Nucleus (Probable)
Secondary accessions : Q14CT9Explore the universe of human proteins at neXtProt for ATOH1: NX_Q92858 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q92858 ATOH1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_005163.1 ENSEMBL proteins: ENSP00000302216 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
ISS --
ATOH1 for ontologies About GeneDecksing ATOH1 Antibody Products: Assay Products for ATOH1:
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Protein
Domains / Familiesfor ATOH1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ATOH1 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q92858 ProtoNet protein and cluster: Q92858
1 Blocks protein family : IPB001092 Basic helix-loop-helix dimerization domain bHLH UniProtKB/Swiss-Prot: ATOH1_HUMAN, Q92858 Similarity : Contains 1 bHLH (basic helix-loop-helix) domain
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Functionfor ATOH1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ATOH1_HUMAN, Q92858 Function : Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but theactivity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity)
Genatlas biochemistry entry for ATOH1 : Drosophila atonal proneural gene homolog,involved in the development of nervous system Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ATOH1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ATOH1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ATOH1 (NM_005172 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATOH1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ATOH1
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
ATOH1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ATOH1 :Animal Models: Mouse knock-outs for ATOH1: Atoh1 tm1Hzo Atoh1 tm3.1Hzo 10 MGI mutant phenotypes (inferred from 9 alleles ) (MGI details for Atoh1) :
ATOH1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ATOH1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Transcription factors in neurogenesis
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for ATOH1
ATOH1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATOH1 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)5 Interacting proteins for ATOH1 (Q92858 3 ENSP00000302216 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20 ): About this table
ATOH1 for ontologies About GeneDecksing
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Drugs & Compoundsfor ATOH1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ATOH1 Search CenterWatch for drugs/clinical trials and news about ATOH1
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Transcriptsfor ATOH1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ATOH1 gene: NM_005172.1 Unigene Cluster for ATOH1:
Atonal homolog 1 (Drosophila) Hs.532680 Unigene Representative Sequence: BC113623 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000306011 (uc003hta.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ATOH1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ATOH1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ATOH1 (NM_005172 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATOH1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ATOH1
Additional cDNA sequence: BC069145.1 BC069578.1 BC069594.1 BC069604.1 BC113623.1 BC113625.1
1 DOTS entry : DT.91670860
5 AceView cDNA sequences :
BC069578 BC069604 BC069145 NM_005172 BC069594 GeneLoc Exon Structure
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Expression for ATOH1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ATOH1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGCTGAACCA
About this image ATOH1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Neural Tube Metencephalon Neural Tube Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ATOH1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ATOH1 SOURCE GeneReport for Unigene cluster: Hs.532680 SABiosciences Custom PCR Arrays for ATOH1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ATOH1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ATOH1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ATOH1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ATOH1
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Orthologsfor ATOH1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ATOH1 gene from 5/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for ATOH1 (if available)TreeFam Gene Tree for ATOH1 (if available)
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Paralogsfor ATOH1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ATOH1 gene NEUROG3 2 FERD3L 2 NEUROD2 2 NEUROD1 2 NEUROD6 2 NEUROG2 2 BHLHA15 2 PTF1A 2 ATOH7 2 NEUROG1 2 NEUROD4 2 4 SIMAP similar genes for ATOH1 using alignment to 2 protein entries: ATOH1_HUMAN (see all proteins ):ATOH7 TAL2 FERD3L BHLHA15
ATOH1 for paralogs About GeneDecksing
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Genomic Variantsfor ATOH1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ATOH1 1 CNV : 0276 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ATOH1
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Disorders
/ Diseasesfor ATOH1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ATOH1 for disorders About GeneDecksing
OMIM gene information: 601461
OMIM disorders : --12 diseases for ATOH1 : About MalaCards cerebellar liponeurocytoma sensorineural hearing loss hearing loss merkel cell carcinoma neuroendocrine tumor colon cancer colon adenocarcinoma adenocarcinoma cerebritis retinitis carcinoma neuronitis 3 diseases from the University of Copenhagen DISEASES database for ATOH1 :Medulloblastoma Sensorineural hearing loss Cerebellar liponeurocytoma 2 Novoseek disease relationships for ATOH1 gene About this table
Export disorders for ATOH1 gene to outside databases
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Publicationsfor ATOH1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ATOH1 gene, integrated from 9 sources (see all 53 ): (articles sorted by number of sources associating them with ATOH1) Utopia : connect your pdf to the dynamic world of online information
Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. (PubMed id 8872459) 1 , 2 , 3 Ben-Arie N....Zoghbi H.Y. (1996) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. (PubMed id 17549667) 1 , 9 Westerman B.A....Oudejans C.B. (2007) The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1. (PubMed id 16831200) 1 , 9 Mutoh H....Sugano K. (2006) Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. (PubMed id 18275842) 1 , 9 Aragaki M....Watanabe M. (2008) A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma. (PubMed id 16382053) 1 , 9 Leow C.C....Gao W.Q. (2005) Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development. (PubMed id 11889557) 1 , 9 Brown N.L.... Glaser T. (2002) Atoh1 directs the formation of sensory mosaics and ind uces cell proliferation in the postnatal mammalian cochlea in vivo. (PubMed id 22573692) 1 Kelly M.C....Chen P. (2012) Atoh1, an essential transcription factor in neurogenes is and intestinal and inner ear development: function, regulation, and context d ependency. (PubMed id 22370966) 1 Mulvaney J. and Dabdoub A. (2012) Age-dependent in vivo conversion of mouse cochlear pil lar and Deiters' cells to immature hair cells by Atoh1 ectopic expression. (PubMed id 22573682) 1 Liu Z....Zuo J. (2012)
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External Searches for ATOH1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ATOH1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ATOH1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ATOH1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ATOH1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ATOH1 gene: Search GeneIP for patents involving ATOH1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ATOH1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ATOH1 OriGene shRNA RFP for ATOH1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ATOH1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ATOH1 OriGene Protein Over-expression Lysate for ATOH1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ATOH1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ATOH1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ATOH1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ATOH1 OriGene Custom Protein Services for ATOH1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATOH1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ATOH1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ATOH1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ATOH1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ATOH1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ATOH1
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Recombinant Protein for ATOH1
ATOH1 Proteins, Antibodies, CLIAs, and ELISAs
ThermoFisher Antibodies for ATOH1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ATOH1
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Aliases for ATOH1
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Disorders / Diseases for ATOH1
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Expression for ATOH1
Function for ATOH1
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