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Aliases for ATMIN Gene

Aliases for ATMIN Gene

  • ATM Interactor 2 3 5
  • ATM/ATR-Substrate Chk2-Interacting Zn++-Finger Protein 2 3
  • ATM/ATR-Substrate CHK2-Interacting Zinc Finger Protein 3 4
  • ATM INteracting Protein 2 3
  • Zinc Finger Protein 822 3 4
  • ZNF822 3 4
  • ASCIZ 3 4
  • ATM/ATR-Substrate CHEK2-Interacting Zinc Finger Protein 3
  • KIAA0431 4

External Ids for ATMIN Gene

Previous GeneCards Identifiers for ATMIN Gene

  • GC16P079628
  • GC16P081069
  • GC16P066826

Summaries for ATMIN Gene

GeneCards Summary for ATMIN Gene

ATMIN (ATM Interactor) is a Protein Coding gene. GO annotations related to this gene include transcription regulatory region DNA binding and dynein binding.

UniProtKB/Swiss-Prot for ATMIN Gene

  • Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATMIN Gene

Genomics for ATMIN Gene

Regulatory Elements for ATMIN Gene

Enhancers for ATMIN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATMIN on UCSC Golden Path with GeneCards custom track

Promoters for ATMIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATMIN on UCSC Golden Path with GeneCards custom track

Genomic Location for ATMIN Gene

Chromosome:
16
Start:
81,035,847 bp from pter
End:
81,047,358 bp from pter
Size:
11,512 bases
Orientation:
Plus strand

Genomic View for ATMIN Gene

Genes around ATMIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATMIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATMIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATMIN Gene

Proteins for ATMIN Gene

  • Protein details for ATMIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43313-ATMIN_HUMAN
    Recommended name:
    ATM interactor
    Protein Accession:
    O43313
    Secondary Accessions:
    • A8K4H8
    • Q68DC9

    Protein attributes for ATMIN Gene

    Size:
    823 amino acids
    Molecular mass:
    88348 Da
    Quaternary structure:
    • Interacts via its C-terminus with ATM. Interacts with DYNLL1; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN.
    SequenceCaution:
    • Sequence=BAA24861.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAF83632.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATMIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATMIN Gene

Proteomics data for ATMIN Gene at MOPED

Post-translational modifications for ATMIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATMIN Gene

Antibody Products

  • Abcam antibodies for ASCIZ

No data available for DME Specific Peptides for ATMIN Gene

Domains & Families for ATMIN Gene

Gene Families for ATMIN Gene

Protein Domains for ATMIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATMIN Gene

Graphical View of Domain Structure for InterPro Entry

O43313

UniProtKB/Swiss-Prot:

ATMIN_HUMAN :
  • Contains 2 C2H2-type zinc fingers.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ATMIN: view

Function for ATMIN Gene

Molecular function for ATMIN Gene

UniProtKB/Swiss-Prot Function:
Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription.

Gene Ontology (GO) - Molecular Function for ATMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044212 transcription regulatory region DNA binding IEA --
genes like me logo Genes that share ontologies with ATMIN: view
genes like me logo Genes that share phenotypes with ATMIN: view

Animal Models for ATMIN Gene

MGI Knock Outs for ATMIN:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATMIN Gene

Localization for ATMIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATMIN Gene

Nucleus. Note=Nuclear, in discrete foci during G1 phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATMIN Gene COMPARTMENTS Subcellular localization image for ATMIN gene
Compartment Confidence
nucleus 5
cytoskeleton 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ATMIN Gene

Pathways & Interactions for ATMIN Gene

SuperPathways for ATMIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 22167198
GO:0060271 cilium morphogenesis IEA --
genes like me logo Genes that share ontologies with ATMIN: view

No data available for Pathways by source and SIGNOR curated interactions for ATMIN Gene

Drugs & Compounds for ATMIN Gene

No Compound Related Data Available

Transcripts for ATMIN Gene

Unigene Clusters for ATMIN Gene

ATM interactor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATMIN Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for ATMIN Gene

GeneLoc Exon Structure for
ATMIN
ECgene alternative splicing isoforms for
ATMIN

Expression for ATMIN Gene

mRNA expression in normal human tissues for ATMIN Gene

Protein differential expression in normal tissues from HIPED for ATMIN Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATMIN Gene



SOURCE GeneReport for Unigene cluster for ATMIN Gene Hs.16349

mRNA Expression by UniProt/SwissProt for ATMIN Gene

O43313-ATMIN_HUMAN
Tissue specificity: Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle.
genes like me logo Genes that share expression patterns with ATMIN: view

Protein tissue co-expression partners for ATMIN Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ATMIN Gene

Orthologs for ATMIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ATMIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATMIN 35
  • 86.85 (n)
  • 87.15 (a)
ATMIN 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATMIN 35
  • 87.83 (n)
  • 88.47 (a)
ATMIN 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atmin 35
  • 81.25 (n)
  • 80.23 (a)
Atmin 16
Atmin 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATMIN 35
  • 99.35 (n)
  • 98.95 (a)
ATMIN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atmin 35
  • 81.07 (n)
  • 82.05 (a)
oppossum
(Monodelphis domestica)
Mammalia ATMIN 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATMIN 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATMIN 35
  • 72.97 (n)
  • 70.43 (a)
ATMIN 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATMIN 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atmin 35
  • 62.47 (n)
  • 57.99 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19802 35
LOC571606 35
  • 59.76 (n)
  • 56.17 (a)
atmin 36
  • 52 (a)
OneToOne
Species with no ortholog for ATMIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATMIN Gene

ENSEMBL:
Gene Tree for ATMIN (if available)
TreeFam:
Gene Tree for ATMIN (if available)

Paralogs for ATMIN Gene

(1) SIMAP similar genes for ATMIN Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ATMIN Gene

genes like me logo Genes that share paralogs with ATMIN: view

No data available for Paralogs for ATMIN Gene

Variants for ATMIN Gene

Sequence variations from dbSNP and Humsavar for ATMIN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2278022 - 81,043,216(+) AGTTA(C/T)CCAAC reference, missense
rs2278023 - 81,043,411(+) TGGTT(A/G)AACTA reference, missense
rs11537 -- 81,046,894(+) GTTTG(A/C/G)TTTGG utr-variant-3-prime
rs13185 -- 81,046,036(+) TGAGC(A/G)TAGGT utr-variant-3-prime
rs13861 -- 81,046,076(+) GAAAC(A/G)TGCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATMIN Gene

Variant ID Type Subtype PubMed ID
nsv1897 CNV Loss 18451855
esv2422360 CNV Duplication 17116639
esv25835 CNV Loss 19812545
dgv356n27 CNV Loss 19166990

Variation tolerance for ATMIN Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATMIN Gene

Disorders for ATMIN Gene

Relevant External Links for ATMIN

Genetic Association Database (GAD)
ATMIN
Human Genome Epidemiology (HuGE) Navigator
ATMIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATMIN

No disorders were found for ATMIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATMIN Gene

Publications for ATMIN Gene

  1. ATMIN defines an NBS1-independent pathway of ATM signalling. (PMID: 17525732) Kanu N. … Behrens A. (EMBO J. 2007) 2 3 4 67
  2. ATMINistrating ATM signalling: regulation of ATM by ATMIN. (PMID: 19001856) Kanu N. … Behrens A. (Cell Cycle 2008) 2 3
  3. DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion. (PMID: 18433721) Oka H. … Taniguchi Y. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage. (PMID: 15933716) McNees C.J. … Heierhorst J. (EMBO J. 2005) 2 3
  5. UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function. (PMID: 25092319) Zhang T. … Behrens A. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for ATMIN Gene

Sources for ATMIN Gene

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