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ATMIN Gene

protein-coding   GIFtS: 50
GCID: GC16P081069

ATM Interactor

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ATM Interactor1 2     ZNF8222 3
ASCIZ2 3 5     ATM/ATR-Substrate CHK2-Interacting Zinc Finger Protein2 3
ATM INteracting Protein1 2     KIAA04313 5
ATM/ATR-Substrate Chk2-Interacting Zn++-Finger Protein1 2     ATM/ATR-Substrate CHEK2-Interacting Zinc Finger Protein2
Zinc Finger Protein 8222 3     

External Ids:    HGNC: 290341   Entrez Gene: 233002   Ensembl: ENSG000001664547   OMIM: 6146935   UniProtKB: O433133   

Export aliases for ATMIN gene to outside databases

Previous GC identifers: GC16P079628 GC16P066826


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATMIN Gene:
ATMIN (ATM interactor) is a protein-coding gene. GO annotations related to this gene include dynein binding and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot: ATMIN_HUMAN, O43313
Function: Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to
methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role
in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATMIN gene promoter:
         GR   ISGF-3   RFX1   GR-beta   Egr-1   Olf-1   CUTL1   STAT5A   Egr-4   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATMIN promoter sequence
   Search Chromatin IP Primers for ATMIN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATMIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.2   Ensembl cytogenetic band:  16q23.2   HGNC cytogenetic band: 16q23.2

ATMIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATMIN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P081069:  view genomic region     (about GC identifiers)

Start:
81,069,452 bp from pter      End:
81,080,963 bp from pter
Size:
11,512 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATMIN_HUMAN, O43313 (See protein sequence)
Recommended Name: ATM interactor  
Size: 823 amino acids; 88348 Da
Subunit: Interacts via its C-terminus with ATM. Interacts with DYNLL1; this interaction inhibits ATMIN
transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of
its own promoter by ATMIN
Sequence caution: Sequence=BAA24861.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAF83632.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K4H8 Q68DC9
Alternative splicing: 2 isoforms:  O43313-1   O43313-2   

Explore the universe of human proteins at neXtProt for ATMIN: NX_O43313

Explore proteomics data for ATMIN at MOPED


See ATMIN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_056066.2  
ENSEMBL proteins: 
 ENSP00000299575   ENSP00000463478   ENSP00000464427   ENSP00000455497  

ATMIN Human Recombinant Protein Products:

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Novus Biologicals ATMIN Protein
Novus Biologicals ATMIN Lysate
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Cloud-Clone Corp. Proteins for ATMIN

 
Search eBioscience for Proteins for ATMIN 

ATMIN Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of ATMIN
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OriGene Custom Antibody Services for ATMIN
Novus Biologicals ATMIN Antibodies
Abcam antibodies for ATMIN
Cloud-Clone Corp. Antibodies for ATMIN
Search ThermoFisher Antibodies for ATMIN
LSBio Antibodies in human, mouse, rat for ATMIN

ATMIN Assay Products:

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Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for ATMIN
Cloud-Clone Corp. CLIAs for ATMIN
Search eBioscience for ELISAs for ATMIN 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

2 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry O43313

ProtoNet protein and cluster: O43313

UniProtKB/Swiss-Prot: ATMIN_HUMAN, O43313
Similarity: Contains 2 C2H2-type zinc fingers


Find genes that share domains with ATMIN           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ATMIN_HUMAN, O43313
Function: Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to
methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role
in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI17525732
GO:0044212transcription regulatory region DNA binding IEA--
GO:0045502dynein binding IPI--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ATMIN           About GenesLikeMe


Phenotypes:
     11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Atmin):
 behavior/neurological  cardiovascular system  cellular  craniofacial  growth/size/body 
 hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
 respiratory system 

Find genes that share phenotypes with ATMIN           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for ATMIN: Atmintm1.1Jhh Atmintm1.1Axbe

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATMIN
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATMIN
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATMIN

miRNA
Products:
    
miRTarBase miRNAs that target ATMIN:
hsa-mir-425-3p (MIRT042422), hsa-mir-744-5p (MIRT037692), hsa-mir-19b-3p (MIRT031215), hsa-mir-21-5p (MIRT031014), hsa-mir-130b-3p (MIRT020249)

Block miRNA regulation of human, mouse, rat ATMIN using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ATMIN (see all 42):
hsa-miR-2052 hsa-miR-3607-3p hsa-miR-4307 hsa-miR-4328 hsa-miR-429 hsa-miR-374a hsa-miR-449a hsa-miR-374c
SwitchGear 3'UTR luciferase reporter plasmidATMIN 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for ATMIN
Predesigned siRNA for gene silencing in human, mouse, rat ATMIN

Gene Editing
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Clone
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OriGene clones in human, mouse for ATMIN (see all 7)
OriGene ORF clones in mouse, rat for ATMIN
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ATMIN (NM_015251)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATMIN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATMIN
Addgene plasmids for ATMIN 

Cell Line
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GenScript Custom overexpressing Cell Line Services for ATMIN
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATMIN


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ATMIN_HUMAN, O43313: Nucleus. Note=Nuclear, in discrete foci during G1 phase
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--

Find genes that share ontologies with ATMIN           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATMIN
Interactions:

    Search GeneGlobe Interaction Network for ATMIN

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

4 Interacting proteins for ATMIN (O433131, 2, 3 ENSP000002995754) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ATMQ133151, 2, 3, ENSP000002786164EBI-7422202,EBI-495465 MINT-4979579 MINT-4979598 MINT-4979635 MINT-4979556 MINT-4979615 I2D: score=1 STRING: ENSP00000278616
ATRQ135353I2D: score=2 
CHEK2O960173I2D: score=1 
MAPK6Q166593I2D: score=1 
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006974cellular response to DNA damage stimulus IEA--
GO:0045893positive regulation of transcription, DNA-templated IDA--

Find genes that share ontologies with ATMIN           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ATMIN



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ATMIN gene: 
NM_015251.2  

Unigene Clusters for ATMIN:

ATM interactor
Hs.16349  [show with all ESTs], Hs.589959  [show with all ESTs]
Unigene Representative Sequences: NM_015251, AK302556
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000299575(uc002ffz.1) ENST00000562969 ENST00000539819 ENST00000564241(uc002fga.2 uc010vnn.1)
ENST00000565237 ENST00000566488(uc002fgb.1)
miRNA
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Block miRNA regulation of human, mouse, rat ATMIN using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ATMIN (see all 42):
hsa-miR-2052 hsa-miR-3607-3p hsa-miR-4307 hsa-miR-4328 hsa-miR-429 hsa-miR-374a hsa-miR-449a hsa-miR-374c
SwitchGear 3'UTR luciferase reporter plasmidATMIN 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat ATMIN
Clone
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GenScript: all cDNA clones in your preferred vector: ATMIN (NM_015251)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATMIN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATMIN
Addgene plasmids for ATMIN 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for ATMIN
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATMIN
  QuantiTect SYBR Green Assays in human, mouse, rat ATMIN
  QuantiFast Probe-based Assays in human, mouse, rat ATMIN

Additional mRNA sequence: AK302556.1 

24 DOTS entries:

DT.98132133  DT.100789655  DT.91827985  DT.100789659  DT.91654180  DT.92019225  DT.97771312  DT.120699340 
DT.91903189  DT.100712549  DT.100789658  DT.120882176  DT.120927408  DT.120927497  DT.120927763  DT.40291255 
DT.91742731  DT.92370997  DT.97844445  DT.100720189  DT.101980064  DT.120927548  DT.91879950  DT.91994954 

Selected AceView cDNA sequences (see all 313):

W40121 CB143735 BI061413 AI354693 AA806028 AI927910 AI683879 AA534578 
BQ019752 AI744148 CF138407 BC002701 AA565222 BI062770 AA810542 CA390851 
AW511347 AI432178 AU130720 AI079697 BI062258 AW236817 Z38264 AI354700 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ATMIN    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:              -           -                     
SP2:                          -     -               
SP3:              -                                 


ECgene alternative splicing isoforms for ATMIN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ATMIN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTGAAATGG
ATMIN Expression
About this image

ATMIN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ATMIN Protein Expression

SOURCE GeneReport for Unigene clusters: Hs.16349 Hs.589959

UniProtKB/Swiss-Prot: ATMIN_HUMAN, O43313
Tissue specificity: Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta
and skeletal muscle

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATMIN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ATMIN gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Atmin1 , 5 ATM interactor1, 5 81.25(n)1
80.23(a)1
  8 (63.37 cM)5
2347761  NM_177700.41  NP_808368.31 
 1169433935 
chicken
(Gallus gallus)
Aves ATMIN1 ATM interactor 72.97(n)
70.43(a)
  426138  XM_423809.4  XP_423809.3 
lizard
(Anolis carolinensis)
Reptilia ATMIN6
ATM interactor
65(a)
1 ↔ 1
LGc(5681509-5687968)
tropical clawed frog
(Xenopus tropicalis)
Amphibia atmin1 ATM interactor 62.47(n)
57.99(a)
  100487308  XM_002938145.2  XP_002938191.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.198022 Transcribed sequence with moderate similarity to protein more 74.03(n)    AL925742.1 


ENSEMBL Gene Tree for ATMIN (if available)
TreeFam Gene Tree for ATMIN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ATMIN gene
1 SIMAP similar gene for ATMIN using alignment to 2 protein entries:     ATMIN_HUMAN (see all proteins):
ASCIZ

Find genes that share paralogs with ATMIN           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for ATMIN
PGOHUM00000239469 PGOHUM00000236714


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ATMIN (see all 420)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1851794331,2
--81067476(+) GGCGTA/GAGCCA 1 -- us2k10--------
rs1478910231,2
--81067487(+) CCATGA/CCTGGC 1 -- us2k10--------
rs1898047761,2
--81067771(+) GGAAGA/GCACAT 1 -- us2k10--------
rs782511401,2
F--81067828(+) ATGCAT/GAGGGC 1 -- us2k11Minor allele frequency- G:0.02WA 118
rs1820957531,2
--81067929(+) TTTGGA/GATTTT 1 -- us2k10--------
rs1877943851,2
--81068099(+) TCATCA/GGTCAA 1 -- us2k10--------
rs118631581,2
C,F,A,H--81068130(+) caccaA/Ttttgc 1 -- us2k19Minor allele frequency- T:0.18NA CSA WA EA 370
rs118631661,2
C,F,H--81068182(+) caaatA/Gtatac 1 -- us2k15Minor allele frequency- G:0.01NS NA 412
rs748040511,2
F--81068268(+) GCCCAA/GTGTCA 1 -- us2k10--------
rs1480831011,2
--81068367(+) TTACTC/GATTCT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ATMIN (81069452 - 81080963 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for ATMIN:    About this table    
Variant IDTypeSubtypePubMed ID
esv2422360CNV Duplication17116639
nsv1897CNV Loss18451855
dgv356n27CNV Loss19166990
esv25835CNV Loss19812545

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ATMIN
DNA2.0 Custom Variant and Variant Library Synthesis for ATMIN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614693    OMIM disorders: --


Find genes that share disorders with ATMIN           About GenesLikeMe

Genetic Association Database (GAD): ATMIN
Human Genome Epidemiology (HuGE) Navigator: ATMIN (1 document)

Export disorders for ATMIN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ATMIN gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with ATMIN)
    Utopia: connect your pdf to the dynamic
world of online information

  1. ATMIN defines an NBS1-independent pathway of ATM signalling. (PubMed id 17525732)1, 2, 3 Kanu N. and Behrens A. (EMBO J. 2007)
  2. ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage. (PubMed id 15933716)1, 2, 3 McNees C.J.... Heierhorst J. (EMBO J. 2005)
  3. ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression. (PubMed id 22167198)1, 2 Jurado S.... Heierhorst J. (J. Biol. Chem. 2012)
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
  5. ATMINistrating ATM signalling: regulation of ATM by ATMIN. (PubMed id 19001856)1, 3 Kanu N. and Behrens A. (Cell Cycle 2008)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1997)
  8. DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion. (PubMed id 18433721)1, 9 Oka H....Taniguchi Y. (Biochem. Biophys. Res. Commun. 2008)
  9. LC8 dynein light chain (DYNLL1) binds to the C-terminal domain of ATM-interacting protein (ATMIN/ASCIZ) and regulates its subcellular localization. (PubMed id 21971545)1 Rapali P....Rodriguez-Crespo I. (Biochem. Biophys. Res. Commun. 2011)
  10. Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. (PubMed id 20975950)1 Jurado S....Heierhorst J. (PLoS Genet. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23300 HGNC: 29034 AceView: KIAA0431 Ensembl:ENSG00000166454 euGenes: HUgn23300
ECgene: ATMIN H-InvDB: ATMIN

(According to HUGE)
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HUGE: KIAA0431

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ATMIN Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ATMIN gene:
Search GeneIP for patents involving ATMIN

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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