ATM Gene
protein-coding GIFtS : 76 GCID: GC11 P108093
ataxia telangiectasia mutated ataxia telangiectasia mutated (includes complementation... ATA, ATDC, ATC, ATD )
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Aliasesfor ATM gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ataxia Telangiectasia Mutated 1 2 3 EC 2.7.11.13 8 ATA1 2 5 AT12 5 ATC1 2 Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C And D)1 ATD1 2 ATE2 ATDC1 2 AT Mutated2 TEL11 2 Serine-Protein Kinase ATM2 TELO11 2 TEL1, Telomere Maintenance 1, Homolog2 A-T Mutated2 3
Export aliases for ATM gene to outside databases Previous GC identifers: GC11P110302 GC11P109450 GC11P108127 GC11P107631 GC11P107599 GC11P104019
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Summariesfor ATM gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ATM : The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. (provided by RefSeq, Aug 2010) UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 Function : Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation summary
for ATM : ATM (Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related) are closely relatedkinases that are activated by DNA damage. These serine-threonine protein kinases are part of thephosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage bindingproteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint byphosphorylating a number of key proteins. Once activated, the checkpoint leads to cell cycle arrest andeither DNA repair or apoptosis. ATM is activated by double stranded breaks and phosphorylates Chk2, whilstATR is activated by single strand breaks and phosphorylates Chk1. Gene Wiki entry for ATM (Ataxia telangiectasia mutated)
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Genomic Viewsfor ATM gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ATM gene promoter:CREB AP-1 deltaCREB ATF-2 c-Jun STAT5A Other transcription factors Search SABiosciences Chromatin IP Primers for ATM Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q22-q23 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22-q23 ATM Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P108093: view genomic region
(about GC identifiers )
Start: 108,093,211 bp from pter End:
108,239,829 bp from pter
Size: 146,619 bases Orientation:
plus strand
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Proteinsfor ATM gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 See
protein sequence )Recommended Name: Size : 3056 amino acids; 350714 DaSubunit : Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomersrendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with RAD17; DNA damage promotes the association. Interacts with EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, KAT8, KAT5, NABP2, ATMIN and CEP164. Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity). Interacts with TELO2 and TTI1. Interacts with DDX1
Subcellular location : Nucleus. Cytoplasmic vesicle. Note=Primarily nuclear. Found also in endocytic vesicles inassociation with beta-adaptin
Sequence caution : Sequence=AAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAA86520.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI37170.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI37170.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=EAW67111.1; Type=Erroneous gene model prediction;
Secondary accessions : B2RNX5 O15429 Q12758 Q16551 Q93007 Q9NP02 Q9UCX7Explore the universe of human proteins at neXtProt for ATM: NX_Q13315 Post-translational modifications:
Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated activation of the kinase1
Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP601
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q13315 4/6 DME Specific Peptides for ATM (Q13315 ) (see all 6 )ATM Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_000042.3 ENSEMBL proteins: ENSP00000435747 ENSP00000433955 ENSP00000432318 ENSP00000388058 ENSP00000432560 ENSP00000431839 ENSP00000434327 ENSP00000435524 ENSP00000278616 Reactome Protein details: Q13315 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing ATM Antibody Products: Assay Products for ATM:
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Protein
Domains /for ATM gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/9 InterPro domains/families (see all 9 ):
Graphical View of Domain Structure for InterPro Entry Q13315 ProtoNet protein and cluster: Q13315
2 Blocks protein families : IPB000403 IPB003151 UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 Domain : The FATC domain is required for interaction with KAT5Similarity : Belongs to the PI3/PI4-kinase family. ATM subfamilySimilarity : Contains 1 FAT domainSimilarity : Contains 1 FATC domainSimilarity : Contains 1 PI3K/PI4K domain
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Functionfor ATM gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 Function : Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : Inhibited by wortmanninInduction : By ionizing radiation
Genatlas biochemistry entry for ATM ataxia telangiectasia,mutated,protein kinase,involved in cellular responses to ionizing radiation (IR)-induced DNA damage such as double strand breaks and cell cycle control through phosphorylation of BRCA1,homologous to cell cycle G2 checkpoint gene yeast MEC1 and related TEL1,RAD3 (S pombe),Drosophila mei-41,also homologous to yeast TOR1,TOR2, activating TP53 in association with 14.3.3 proteins YWHA*,and leading to cell cycle arrest and apoptosis,also activating ABL1 (cABL) and TP73 in a mismatch repair dependent apoptosis pathway,interacting with beta adaptin for the axonal transport and vesicle trafficking in the central nervous system,mutated (somatic mutation) in B cell chronic lymphocytic leukemia,also mutated in ataxia telangiectasia (see AT),but not mutated in childhood T-ALL,deleted in mantle cell lymphoma (see also TSG11F) Enzyme Number (IUBMB): EC 2.7.11.1 1 2 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ATM (NM_000051 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATM Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ATM
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing 4 GenomeRNAi human phenotypes for ATM :Animal Models: Atm tm1Pmc Atm tm1Awb Atm tm1Led Atm tm1Bal Atm tm1Fwa Atm tm1Mfl 12 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Atm) :About GeneDecksing
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Pathways & Interactionsfor ATM gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/44 super-pathways (see all 44 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ubiquitinated Orc1 is degraded by the proteasome 2 Fanconi Anemia pathway 3 Chks in Checkpoint Regulation 4 Formation of Meiotic Holliday Junction 5 Apoptotic Pathways in Synovial Fibroblasts
Pathway sources See GeneCards unified pathways Show all pathways 5 5/17 (see all 17 )2 1 5 5/19 (see all 19 ) 5/27 (see all 27 )1 ATM 3 (Kegg details for ATM) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATM STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/680 Interacting proteins for ATM (Q13315 1 , 2 , 3 ENSP00000278616 4 via UniProtKB, MINT, STRING , and/or I2D (see all 680 )Interactant Interaction Details GeneCard External ID(s) ATMIN O43313 2 , 3 ENSP00000299575 4 MINT-4979579 MINT-4979598 MINT-4979635 MINT-4979556 MINT-4979615 I2D:
score=1 STRING: ENSP00000299575 H2AFX P16104 2 , 3 ENSP00000364310 4 MINT-2843419 I2D:
score=6 STRING: ENSP00000364310 TP53 P04637 2 , 3 ENSP00000269305 4 MINT-49767 I2D:
score=6 STRING: ENSP00000269305 MDC1 Q14676 1 , 3 ENSP00000365588 4 EBI-1059333,EBI-495644 I2D:
score=4 STRING: ENSP00000365588 PRKDC P78527 2 , 3 ENSP00000313420 4 MINT-7945693 I2D:
score=3 STRING: ENSP00000313420
About this table Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000075 cell cycle checkpoint
TAS -- GO:0000077 DNA damage checkpoint
-- -- GO:0000723 telomere maintenance
IEA -- GO:0000724 double-strand break repair via homologous recombination
TAS -- GO:0001666 response to hypoxia
IEA --
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Drugs & Compoundsfor ATM gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for ATM available from Tocris Bioscience About this table Compound Action
CAS
# KU 55933 Potent and selective ATM kinase inhibitor [587871-26-9] KU 60019 Potent ATM kinase inhibitor [925701-46-8] CGK 733 Selective inhibitor of ATR and ATM kinases [905973-89-9] Mirin MRN-ATM pathway inhibitor --
2 HMDB Compounds for ATM About this table 10/46 Novoseek chemical compound relationships for ATM gene (see all 46 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol
58.6
27
11114307 (1), 17507690 (1), 9442910 (1), 12513844 (1) (see all 24 )
wortmannin
56.5
24
10771089 (3), 15173573 (2), 9808536 (2), 15709017 (1) (see all 14 )
neocarzinostatin
50.7
3
15345673 (1), 9244351 (1), 9050866 (1)
caffeine
50.2
33
10485486 (4), 16479016 (2), 11864911 (2), 10744722 (2) (see all 19 )
aphidicolin
46.5
5
11279043 (1), 11114888 (1)
hydroxyurea
43.4
6
11689451 (1), 16293623 (1), 11114888 (1)
topotecan
35.2
11
18802408 (3), 16426422 (3), 16760673 (2), 16184611 (1)
camptothecin
32.1
15
20304914 (5), 15699047 (2), 16158199 (1), 10327072 (1)
mitoxantrone
30.9
10
16760673 (4), 18802408 (3), 16184611 (1), 19411853 (1)
ly294002
30.4
8
10771089 (3), 18589211 (1), 19038232 (1)
ATM
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Transcriptsfor ATM gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ATM gene (3 alternative transcripts): NM_000051.3 NM_138292.3 NM_138293.1 Unigene Cluster for ATM:
Ataxia telangiectasia mutated Hs.367437 [show with all ESTs ] Unigene Representative Sequence: NM_000051 18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26 ): ENST00000527805 (uc009yxs.1 ) ENST00000527891 ENST00000532931 ENST00000530958 ENST00000452508 (uc001pke.2 ) ENST00000526567 (uc001pkc.1 ) ENST00000525012 ENST00000533526 ENST00000532637 ENST00000533470 ENST00000419286 ENST00000531525 (uc001pkf.3 )ENST00000533733 (uc001pkd.4 ) ENST00000524792 ENST00000531957 ENST00000533690 (uc009yxt.1 uc001pkg.1 )ENST00000534625 ENST00000529588 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ATM (NM_000051 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATM Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ATM
Additional cDNA sequence: AF035326.1 AF035327.1 AF035328.1 AK093586.1 AK299843.1 BC007023.2 BC022306.1 BC061584.1 BC152385.1 BC152389.1 BT006764.1 BX640631.1 CR749436.1 HM437232.1 U33841.1 U67093.1 X91196.1 Y08455.1
21 DOTS entries : DT.102832095 DT.100750015
DT.91916232 DT.91717023 DT.101977439 DT.99971554 DT.121643246 DT.451837 DT.100750014 DT.99928041 DT.120760397 DT.65284599 DT.97778369 DT.120760409 DT.120760428 DT.40122485 DT.75194025 DT.91664691 DT.97825561 DT.120760412 DT.99957611 24/200 AceView cDNA sequences (see all 200 ):
AA149504 CD721939 BM671057 BC007023 BQ005085 AA632114 BX096702 AK093586 AA421745 AI523344 BM800438 AA814352 R26821 AL706720 AI559463 AA782580 BX642224 AA962359 AV705298 AI479273 BF981497 U26455 BM451149 AA149636 GeneLoc Exon Structure
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Expression for ATM gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ATM expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image ATM expression in embryonic tissues and stem cells About this table See ATM Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ATM SOURCE GeneReport for Unigene cluster: Hs.367437 UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 Tissue specificity : Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus,testis, ovary, small intestine, colon and leukocytes SABiosciences Expression via Pathway-Focused PCR Arrays including ATM (see all 13 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM
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Orthologsfor ATM gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ATM gene from 7/26 species (see all 26 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves ATM1
ataxia telangiectasia mutated
72.23(n) 69.69(a)
395401 NM_001162400.1 NP_001155872.1
lizard Reptilia --
--
87(a)
1 ↔ 1
5(124957040-124966704)
African clawed frog Amphibia ATM2
ataxia telangiectasia mutated
75.21(n)
AF174488.1
zebrafish Actinopterygii Dr.286552
Danio rerio partial mRNA for ataxia telangiectasia more
73.34(n)
AJ605775.1
fruit fly Insecta CG65353
cell cycle checkpoint protein kinase
27(a)
--
thale cress eudicotyledons ATM6
serine/threonine-protein kinase
16(a)
1 ↔ 1
3(17797334-17828591)
rice Liliopsida Os.170832
Oryza sativa (japonica cultivar-group) AtATM like protein more
75(n)
NM_183488.1
ENSEMBL Gene Tree for ATM (if available)TreeFam Gene Tree for ATM (if available)
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Paralogsfor ATM gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ATM gene 2 SIMAP similar genes for ATM using alignment to 16 protein entries: ATM_HUMAN (see all proteins ):DKFZp781A0353 MTOR About GeneDecksing 1 Pseudogenes.org Pseudogene for ATM PGOHUM00000233233
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Drugs / Compounds
Expression
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Genomic Variantsfor ATM gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 11 pos Sequence # AA Type More # Allele Pop Total More
summary
for 
GeneGo (Thomson Reuters) Pathways for ATM
PharmGKB Pathway for 
Kegg Pathways 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Microarrays
In-situ hybridization