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ATM Gene

protein-coding   GIFtS: 77
GCID: GC11P108093

Ataxia Telangiectasia Mutated

(Previous names: ataxia telangiectasia mutated (includes complementation...)
(Previous symbols: ATA, ATDC, ATC, ATD)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ataxia Telangiectasia Mutated1 2 3     Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C And D)1
ATA1 2 5     Homolog (S. Cerevisiae)1
ATC1 2     Telomere Maintenance 11
ATD1 2     ATE2
ATDC1 2     TELO12
TEL11 2     AT Mutated2
A-T Mutated2 3     Serine-Protein Kinase ATM2
EC 2.7.11.13 8     TEL1, Telomere Maintenance 1, Homolog2
AT12 5     

External Ids:    HGNC: 7951   Entrez Gene: 4722   Ensembl: ENSG000001493117   OMIM: 6075855   UniProtKB: Q133153   

Export aliases for ATM gene to outside databases

Previous GC identifers: GC11P110302 GC11P109450 GC11P108127 GC11P107631 GC11P107599 GC11P104019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATM Gene:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle
checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream
proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17
and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master
controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for
genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive
disorder. (provided by RefSeq, Aug 2010)

GeneCards Summary for ATM Gene:
ATM (ataxia telangiectasia mutated) is a protein-coding gene. Diseases associated with ATM include mantle cell lymphoma, and ataxia-telangiectasia variant. GO annotations related to this gene include protein serine/threonine kinase activity and protein complex binding.

UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
Function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),
apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage
sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant
H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in
pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to
enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual
B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by
mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to
the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle
control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2,
CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle
and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role
in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in
response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation.
Phosphorylates ATF2 which stimulates its function in DNA damage response

summary for ATM Gene:
ATM (Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related) are closely related
kinases that are activated by DNA damage. These serine-threonine protein kinases are part of the
phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding
proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by
phosphorylating a number of key proteins. Once activated, the checkpoint leads to cell cycle arrest and
either DNA repair or apoptosis. ATM is activated by double stranded breaks and phosphorylates Chk2, whilst
ATR is activated by single strand breaks and phosphorylates Chk1.

Gene Wiki entry for ATM (Ataxia telangiectasia mutated) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATM gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ATM promoter sequence
   Search Chromatin IP Primers for ATM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22-q23

ATM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P108093:  view genomic region     (about GC identifiers)

Start:
108,093,211 bp from pter      End:
108,239,829 bp from pter
Size:
146,619 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 (See protein sequence)
Recommended Name: Serine-protein kinase ATM  
Size: 3056 amino acids; 350687 Da
Subunit: Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers
rendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the
BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and
the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell
cycle and within subnuclear domains. Interacts with RAD17; DNA damage promotes the association. Interacts with
EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, KAT8, KAT5, NABP2,
ATMIN and CEP164. Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity).
Interacts with TELO2 and TTI1. Interacts with DDX1
Sequence caution: Sequence=AAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA86520.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI37170.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI37170.1; Type=Miscellaneous
discrepancy; Note=Probable cloning artifact; Sequence=EAW67111.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RNX5 O15429 Q12758 Q16551 Q93007 Q9NP02 Q9UCX7

Explore the universe of human proteins at neXtProt for ATM: NX_Q13315

Explore proteomics data for ATM at MOPED

Post-translational modifications: 

  • Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA
    damage-mediated activation of the kinase1
  • Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and
    subsequent autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP601
  • Ubiquitination2 at Lys215, Lys1109, Lys1114, Lys1126, Lys1323, Lys1572, Lys1994, Lys2025, Lys2148, Lys2160,
                                 Lys2789, Lys2848
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATM (Q13315) (see all 6)
     TYKVVPL  EPDSLYG  EGVFRRC  DDLRQDA 


    See ATM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000042.3  
    ENSEMBL proteins: 
     ENSP00000435747   ENSP00000433955   ENSP00000432318   ENSP00000388058   ENSP00000469471  
     ENSP00000434327   ENSP00000435524   ENSP00000278616  
    Reactome Protein details: Q13315

    ATM Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ATM Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ATM
    GenScript Custom Purified and Recombinant Proteins Services for ATM
    Novus Biologicals ATM Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATM

    ATM Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATM
    R&D Systems Antibodies for ATM
    Cell Signaling Technology (CST) Antibodies for ATM 
    OriGene Antibodies for ATM
    OriGene Custom Antibody Services for ATM
    Novus Biologicals ATM Antibodies
    Abcam antibodies for ATM
    Cloud-Clone Corp. Antibodies for ATM
    ThermoFisher Antibody for ATM
    LSBio Antibodies in human, mouse, rat for ATM

    ATM Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATM
    R&D Systems ELISAs for ATM
    GenScript Custom Assay Services for ATM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATM
    Cloud-Clone Corp. CLIAs for ATM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: ataxia telangiectasia mutated
    Other PIKK family kinases

    Selected InterPro protein domains (see all 8):
     IPR011009 Kinase-like_dom
     IPR021668 TAN
     IPR014009 PIK_FAT
     IPR000403 PI3/4_kinase_cat_dom
     IPR003151 PIK-rel_kinase_FAT

    Graphical View of Domain Structure for InterPro Entry Q13315

    ProtoNet protein and cluster: Q13315

    2 Blocks protein domains:
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003151 PIK-related kinase


    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
    Domain: The FATC domain is required for interaction with KAT5
    Similarity: Belongs to the PI3/PI4-kinase family. ATM subfamily
    Similarity: Contains 1 FAT domain
    Similarity: Contains 1 FATC domain
    Similarity: Contains 1 PI3K/PI4K domain


    ATM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATM_HUMAN, Q13315
    Function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),
    apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage
    sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant
    H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in
    pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to
    enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual
    B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by
    mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to
    the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle
    control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2,
    CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle
    and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role
    in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in
    response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation.
    Phosphorylates ATF2 which stimulates its function in DNA damage response
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by wortmannin
    Induction: By ionizing radiation

         Genatlas biochemistry entry for ATM:
    ataxia telangiectasia,mutated,protein kinase,involved in cellular responses to ionizing radiation (IR)-induced DNA
    damage such as double strand breaks and cell cycle control through phosphorylation of BRCA1,homologous to cell
    cycle G2 checkpoint gene yeast MEC1 and related TEL1,RAD3 (S pombe),Drosophila mei-41,also homologous to yeast
    TOR1,TOR2, activating TP53 in association with 14.3.3 proteins YWHA*,and leading to cell cycle arrest and
    apoptosis,also activating ABL1 (cABL) and TP73 in a mismatch repair dependent apoptosis pathway,interacting with
    beta adaptin for the axonal transport and vesicle trafficking in the central nervous system,mutated (somatic
    mutation) in B cell chronic lymphocytic leukemia,also mutated in ataxia telangiectasia (see AT),but not mutated
    in childhood T-ALL,deleted in mantle cell lymphoma (see also TSG11F)

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA11375976
    GO:0004677DNA-dependent protein kinase activity IDA15790808
    GO:0005488binding ----
         
    ATM for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ATM:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  PARP inhibitor sensitization 

         11 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Atm):
     behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  immune system  mortality/aging  nervous system  reproductive system 
     tumorigenesis 

    ATM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ATM: Atmtm1Pmc Atmtm1Awb Atmtm1Led Atmtm1Bal Atmtm1Fwa Atmtm1Mfl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATM

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATM:
    hsa-mir-374a-5p (MIRT005573), hsa-mir-19b-3p (MIRT031122), hsa-mir-18a-5p (MIRT006118), hsa-mir-100-5p (MIRT005913), hsa-mir-101-5p (MIRT005559), hsa-mir-3144-3p (MIRT052661), hsa-mir-421 (MIRT003215), hsa-mir-101-3p (MIRT005560), hsa-mir-181a-5p (MIRT005576), hsa-mir-92a-3p (MIRT049505)

    Block miRNA regulation of human, mouse, rat ATM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATM (see all 15):
    hsa-miR-34c-3p hsa-miR-203 hsa-miR-18a hsa-miR-181c hsa-miR-516b hsa-miR-181a hsa-miR-519c-3p hsa-miR-181d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATM
    Predesigned siRNA for gene silencing in human, mouse, rat ATM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATM

    Clone
    Products:
         
    OriGene clones in human, mouse for ATM (see all 9)
    OriGene ORF clones in mouse, rat for ATM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATM (NM_000051)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATM

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATM
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATM_HUMAN, Q13315: Nucleus. Cytoplasmic vesicle. Note=Primarily nuclear. Found also in endocytic vesicles in
    association with beta-adaptin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3
    cytoskeleton2
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781colocalizes with chromosome, telomeric region IDA15149599
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005819spindle IEA--

    ATM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATM About   (see all 51)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    3CDK-mediated phosphorylation and removal of Cdc6
    Stabilization of p530.92
    p53-Independent DNA Damage Response0.91
    p53-Dependent G1 DNA Damage Response0.92
    Autodegradation of the E3 ubiquitin ligase COP10.91
    p53-Dependent G1/S DNA damage checkpoint0.92
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A0.91
    Cell Cycle Checkpoints0.58
    4Homologous Recombination Repair
    Homologous Recombination Repair0.70
    Recruitment of repair and signaling proteins to double-strand breaks0.00
    Double-Strand Break Repair0.70
    Homologous recombination repair of replication-independent double-strand breaks0.00
    ATM mediated response to DNA double-strand break0.31
    ATM mediated phosphorylation of repair proteins0.00
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    p53 Mediated Apoptosis0.84
    Cellular Apoptosis Pathway0.85
    Telomerase Components in Cell Signaling0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATM (see all 17)
        Telomerase Components in Cell Signaling
    BRCA1 Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    2 Cell Signaling Technology (CST) Pathways for ATM
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 Tocris Bioscience Pathway for ATM
        Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for ATM
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription P53 signaling pathway
    DNA damage DNA-damage-induced responses
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for ATM (see all 19)
        Cell cycle
    DNA damage response
    G1 to S cell cycle control
    DNA damage response (only ATM dependent)
    Homologous recombination

    Selected Reactome Pathways for ATM (see all 11)
        ATM mediated response to DNA double-strand break
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    Regulation of HSF1-mediated heat shock response
    Regulation of the Fanconi anemia pathway
    Stabilization of p53

    1 PharmGKB Pathway for ATM
        Metformin Pathway, Pharmacodynamic

    Selected Kegg Pathways  (Kegg details for ATM) (see all 8):
        NF-kappa B signaling pathway
    FoxO signaling pathway
    Cell cycle
    p53 signaling pathway
    Apoptosis


    ATM for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATM (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ATM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATM (Q133151, 2, 3 ENSP000002786164) via UniProtKB, MINT, STRING, and/or I2D (see all 854)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206481Q146761, 3, ENSP000003730604EBI-495465,EBI-495644 I2D: score=4 STRING: ENSP00000373060
    ENSG00000237095Q146761, 3, ENSP000004091674EBI-495465,EBI-495644 I2D: score=4 STRING: ENSP00000409167
    MDC1Q146761, 3, ENSP000003655884EBI-495465,EBI-495644 I2D: score=4 STRING: ENSP00000365588
    ATMINO433131, 2, 3, ENSP000002995754EBI-495465,EBI-7422202 MINT-4979579 MINT-4979598 MINT-4979635 MINT-4979556 MINT-4979615 I2D: score=1 STRING: ENSP00000299575
    ENSG00000224587Q146761, 3EBI-495465,EBI-495644 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint ----
    GO:0000723telomere maintenance ----
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0001666response to hypoxia IEA--
    GO:0001756somitogenesis IEA--

    ATM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    4 ApexBio Compounds for ATM     About this table
    CompoundAction CAS #
    AZ20potent and selective inhibitor of ATR[1233339-22-4]
    KU 55933Potent and selective ATM inhibitor[587871-26-9]
    KU-60019Potent and selective ATM kinase inhibitor[925701-49-1]
    VE-821Cell-permeable and ATP-competitive ATM kinase inhibitor[1232410-49-9]

    Compounds for ATM available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KU 55933Potent and selective ATM kinase inhibitor[587871-26-9]
    KU 60019Potent ATM kinase inhibitor[925701-46-8]

    2 HMDB Compounds for ATM    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for ATM gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 58.6 27 11114307 (1), 17507690 (1), 9442910 (1), 12513844 (1) (see all 24)
    wortmannin 56.5 24 10771089 (3), 15173573 (2), 9808536 (2), 15709017 (1) (see all 14)
    neocarzinostatin 50.7 3 15345673 (1), 9244351 (1), 9050866 (1)
    caffeine 50.2 33 10485486 (4), 16479016 (2), 11864911 (2), 10744722 (2) (see all 19)
    aphidicolin 46.5 5 11279043 (1), 11114888 (1)
    hydroxyurea 43.4 6 11689451 (1), 16293623 (1), 11114888 (1)
    topotecan 35.2 11 18802408 (3), 16426422 (3), 16760673 (2), 16184611 (1)
    camptothecin 32.1 15 20304914 (5), 15699047 (2), 16158199 (1), 10327072 (1)
    mitoxantrone 30.9 10 16760673 (4), 18802408 (3), 16184611 (1), 19411853 (1)
    ly294002 30.4 8 10771089 (3), 18589211 (1), 19038232 (1)



    ATM for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ATM gene (3 alternative transcripts): 
    NM_000051.3  NM_138292.3  NM_138293.1  

    Unigene Cluster for ATM:

    Ataxia telangiectasia mutated
    Hs.367437  [show with all ESTs]
    Unigene Representative Sequence: NM_000051
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000527805(uc009yxs.1) ENST00000527891 ENST00000532931 ENST00000530958
    ENST00000452508(uc001pke.2) ENST00000526567(uc001pkc.1) ENST00000601453
    ENST00000525012 ENST00000533526 ENST00000419286 ENST00000533733(uc001pkd.4)
    ENST00000524792 ENST00000531525(uc001pkf.3) ENST00000531957 ENST00000533690(uc009yxt.1 uc001pkg.1)
    ENST00000534625 ENST00000529588 ENST00000532765
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATM (see all 15):
    hsa-miR-34c-3p hsa-miR-203 hsa-miR-18a hsa-miR-181c hsa-miR-516b hsa-miR-181a hsa-miR-519c-3p hsa-miR-181d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATM
    Predesigned siRNA for gene silencing in human, mouse, rat ATM
    Clone
    Products:
         
    OriGene clones in human, mouse for ATM (see all 9)
    OriGene ORF clones in mouse, rat for ATM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATM (NM_000051)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATM
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ATM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATM
      QuantiTect SYBR Green Assays in human, mouse, rat ATM
      QuantiFast Probe-based Assays in human, mouse, rat ATM

    Additional mRNA sequence: 

    AF035326.1 AF035327.1 AF035328.1 AK093586.1 AK299843.1 BC007023.2 BC022306.1 BC061584.1 
    BC152385.1 BC152389.1 BT006764.1 BX640631.1 CR749436.1 HM437232.1 U33841.1 U67093.1 
    X91196.1 Y08455.1 

    21 DOTS entries:

    DT.102832095  DT.100750015  DT.91916232  DT.91717023  DT.101977439  DT.99971554  DT.121643246  DT.451837 
    DT.100750014  DT.99928041  DT.120760397  DT.65284599  DT.97778369  DT.120760409  DT.120760428  DT.40122485 
    DT.75194025  DT.91664691  DT.97825561  DT.120760412  DT.99957611 

    Selected AceView cDNA sequences (see all 200):

    AI523344 NM_000051 BX096702 AA962359 AI559463 AA890626 BM671057 BC007023 
    AA236739 AA149636 U26455 BM697241 BG942504 BM800438 AA814352 NM_138292 
    BX642224 BX504088 BX644571 R26821 BQ005085 AI479273 CA392919 AV705298 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ATM expression in normal human tissues (normalized intensities)      ATM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ATM Expression
    About this image


    ATM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Gonad
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primordial Follicle
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    ATM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367437

    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
    Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen,
    thymus, testis, ovary, small intestine, colon and leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATM (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ATM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATM
    QuantiTect SYBR Green Assays in human, mouse, rat ATM
    QuantiFast Probe-based Assays in human, mouse, rat ATM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATM gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atm1 , 5 ataxia telangiectasia mutated homolog (human)1, 5 84.99(n)1
    84.34(a)1
      9 (29.12 cM)5
    119201  NM_007499.21  NP_031525.21 
     534391495 
    chicken
    (Gallus gallus)
    Aves ATM1 ataxia telangiectasia mutated 72.23(n)
    69.69(a)
      395401  NM_001162400.1  NP_001155872.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATM6
    ataxia telangiectasia mutated
    60(a)
    1 ↔ 1
    GL343319.1(1173-53757)
    African clawed frog
    (Xenopus laevis)
    Amphibia ATM2 ataxia telangiectasia mutated 75.21(n)    AF174488.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.286552 Danio rerio partial mRNA for ataxia telangiectasia more 73.34(n)    AJ605775.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65353 cell cycle checkpoint protein kinase 27(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea atm-16
    Protein ATM-1 (atm-1) mRNA, complete cds
    18(a)
    1 ↔ 1
    I(183364-208467) WBGene00000227
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TEL1(YBL088C)4 Protein kinase primarily involved in telomere length more   --   2(59382-51019) 852190  NP_009465.1 
    rice
    (Oryza sativa)
    Liliopsida Os.170832 Oryza sativa (japonica cultivar-group) AtATM like protein more 75(n)    NM_183488.1 


    ENSEMBL Gene Tree for ATM (if available)
    TreeFam Gene Tree for ATM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATM gene
    1 SIMAP similar gene for ATM using alignment to 14 protein entries:     ATM_HUMAN (see all proteins):
    DKFZp781A0353

    ATM for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATM
    PGOHUM00000233233


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATM (see all 3368)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30928571,2,,4
    C,F,HB-cell non-Hodgkin lymphoma4 other1108007477(+) TAAGAA/GTGGCC 2 M V mis126Minor allele frequency- G:0.01NA MN NS EA 7154
    VAR_0108014
    Ataxia telangiectasia (AT)4--see VAR_0108012 K E mis40--------
    VAR_0108464
    Ataxia telangiectasia (AT)4--see VAR_0108462 R C mis40--------
    VAR_0108794
    Ataxia telangiectasia (AT)4--see VAR_0108792 F C mis40--------
    VAR_0108164
    Ataxia telangiectasia (AT)4--see VAR_0108162 L Q mis40--------
    VAR_0108634
    Ataxia telangiectasia (AT)4--see VAR_0108632 D Q mis40--------
    VAR_0415804
    A lung adenocarcinoma sample4--see VAR_0415802 T A mis40--------
    VAR_0108804
    Ataxia telangiectasia (AT)4--see VAR_0108802 P L mis40--------
    VAR_0108264
    Ataxia telangiectasia (AT)4--see VAR_0108262 L P mis40--------
    VAR_0108904
    Ataxia telangiectasia (AT)4--see VAR_0108902 R G mis40--------

    HapMap Linkage Disequilibrium report for ATM (108093211 - 108239829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ATM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832262CNV Loss17160897
    dgv1315n71CNV Loss21882294
    nsv898385CNV Loss21882294
    nsv832263CNV Gain17160897

    Human Gene Mutation Database (HGMD): ATM
    Locus Specific Mutation Databases (LSDB): ATM

    Selected Site Specific Mutation Identification with PCR Assays for ATM (see all 6):
    Cosmic IdAA Change
    20404p.R2443Q
    21826p.F858L
    21624p.R3047*
    12951p.Q2442P
    21642p.R3008C
    5 Site Specific Cancer Mutation PCR Panels containing ATM:
    Lymphoid Neoplasms
    Lung and Colon Cancers (Expanded Panel) 384HT
    Pathway
    Cancer Comprehensive Panel 384HT
    Tumor Suppressor Panel 384HT
    SeqTarget long-range PCR primers for resequencing ATM
    DNA2.0 Custom Variant and Variant Library Synthesis for ATM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 607585   
    OMIM disorders: 208900  114480  
    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
  • Ataxia telangiectasia (AT) [MIM:208900]: A rare recessive disorder characterized by progressive
    cerebellar ataxia, dilation of the blood vessels in the conjunctiva and eyeballs, immunodeficiency, growth
    retardation and sexual immaturity. Patients have a strong predisposition to cancer; about 30% of patients develop
    tumors, particularly lymphomas and leukemias. Cells from affected individuals are highly sensitive to damage by
    ionizing radiation and resistant to inhibition of DNA synthesis following irradiation. Note=The disease is caused
    by mutations affecting the gene represented in this entry
  • Note=Defects in ATM contribute to T-cell acute lymphoblastic leukemia (TALL) and T-prolymphocytic
    leukemia (TPLL). TPLL is characterized by a high white blood cell count, with a predominance of prolymphocytes,
    marked splenomegaly, lymphadenopathy, skin lesions and serous effusion. The clinical course is highly aggressive,
    with poor response to chemotherapy and short survival time. TPLL occurs both in adults as a sporadic disease and
    in younger AT patients
  • Note=Defects in ATM contribute to B-cell non-Hodgkin lymphomas (BNHL), including mantle cell lymphoma
    (MCL)
  • Note=Defects in ATM contribute to B-cell chronic lymphocytic leukemia (BCLL). BCLL is the commonest form
    of leukemia in the elderly. It is characterized by the accumulation of mature CD5+ B-lymphocytes,
    lymphadenopathy, immunodeficiency and bone marrow failure

  • Selected diseases for ATM (see all 130):    About MalaCards
    mantle cell lymphoma    ataxia-telangiectasia variant    chromosome 11q deletion    combined cervical dystonia
    b-cell chronic lymphocytic leukemia    t-cell prolymphocytic leukemia, somatic    lymphoma, b-cell non-hodgkin, somatic    ataxia telangiectasia
    nijmegen breakage syndrome-like disorder    nijmegen breakage syndrome    cll/sll    chronic lymphocytic leukemia
    breast cancer    bilateral breast cancer    ataxia    telangiectasis
    richter's syndrome    prolymphocytic leukemia    t-cell prolymphocytic leukemia    familial chronic lymphocytic leukemia

    10 diseases from the University of Copenhagen DISEASES database for ATM:
    Ataxia telangiectasia     Nijmegen breakage syndrome     Breast cancer     Genetic disorder
    Telangiectasis     Cerebellar ataxia     Leukemia     Lymphoma
    Fanconi's anemia     Seckel syndrome

    ATM for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ATM gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 98.2 473 9622061 (3), 16799570 (3), 7545545 (2), 8843194 (2) (see all 99)
    nijmegen breakage syndrome 87.5 20 15024084 (1), 17507690 (1), 18215521 (1), 18723444 (1) (see all 17)
    cerebellar degeneration 77.4 4 9054948 (1), 9770541 (1), 8968760 (1), 11443540 (1)
    telangiectasia 70.7 13 12882767 (4), 18502988 (2), 19799357 (1), 12513844 (1) (see all 8)
    genetic disorder 69.8 40 10549596 (2), 7545545 (1), 9535798 (1), 10567403 (1) (see all 39)
    lymphocytic leukemia chronic b-cell 65.4 16 11468183 (2), 9892178 (1), 9788599 (1), 10738255 (1) (see all 14)
    cancer 63.5 122 12513844 (4), 18565893 (4), 12195425 (3), 15390180 (3) (see all 83)
    leukemia prolymphocytic 62.7 8 9573030 (2), 10738255 (1), 12149228 (1), 18073348 (1) (see all 7)
    bilateral breast cancer 60.9 10 19153073 (3), 12673797 (1), 14562025 (1), 15756685 (1) (see all 5)
    fanconis anemia 59.3 1 11733219 (1)

    GeneTests: ATM
    GeneReviews: ATM
    Genetic Association Database (GAD): ATM
    Human Genome Epidemiology (HuGE) Navigator: ATM (170 documents)
    Tumor Gene Database (TGDB): ATM

    Export disorders for ATM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ATM gene, integrated from 10 sources (see all 1426) (see top 10):
    (articles sorted by number of sources associating them with ATM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations associated with variant phenotypes in ataxia- telangiectasia. (PubMed id 8755918)1, 2, 4 McConville C.M.... Taylor A.M.R. (Am. J. Hum. Genet. 1996)
    2. ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects. (PubMed id 11849780)1, 4, 9 Iannuzzi C.M....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2002)
    3. Inactivation of the ATM gene in T-cell prolymphocytic leukemias. (PubMed id 9573030)1, 2, 9 Stoppa-Lyonnet D.... Stern M.-H. (Blood 1998)
    4. Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene. (PubMed id 9199932)1, 2, 9 Platzer M.... Rosenthal A. (Genome Res. 1997)
    5. Contribution of mutations in ATM to breast cancer development in the Czech population. (PubMed id 18497957)1, 4, 9 Soukupova J....Pohlreich P. (Oncol. Rep. 2008)
    6. Detection of ATM gene mutations in young lung cancer patients: a population-based control study. (PubMed id 18164969)1, 4, 9 Schneider J....Wichmann H.E. (Arch. Med. Res. 2008)
    7. The product of the ATM gene is a 370-kDa nuclear phosphoprotein. (PubMed id 8969240)1, 2, 9 Chen G. and Lee E.Y.-H.P. (J. Biol. Chem. 1996)
    8. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. (PubMed id 17923702)1, 2, 9 Sun Y.... Price B.D. (Mol. Cell. Biol. 2007)
    9. Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity. (PubMed id 10873394)1, 2, 9 Becker-Catania S.G.... Gatti R.A. (Mol. Genet. Metab. 2000)
    10. Mantle cell lymphoma is characterized by inactivation of the ATM gene. (PubMed id 10706620)1, 2, 9 Schaffner C.... Lichter P. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    11. Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. (PubMed id 10397742)1, 2, 9 Schaffner C.... Lichter P. (Blood 1999)
    12. Genotype-phenotype relationships in ataxia-telangiectasia and variants. (PubMed id 9497252)1, 2, 9 Gilad S.... Bar-Shira A. (Am. J. Hum. Genet. 1998)
    13. ATM associates with and phosphorylates p53: mapping the region of interaction. (PubMed id 9843217)1, 2, 9 Khanna K.K.... Lavin M.F. (Nat. Genet. 1998)
    14. Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study. (PubMed id 20305132)1, 4, 9 Bernstein J.L....Concannon P. (J. Natl. Cancer Inst. 2010)
    15. ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations. (PubMed id 18384426)1, 4, 9 Brunet J....BorrA s J. (Clin. Genet. 2008)
    16. Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma. (PubMed id 17151932)1, 4, 9 Malmer B.S....Henriksson R. (J. Neurooncol. 2007)
    17. ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States). (PubMed id 16049814)1, 4, 9 Jones J.S....Frazier M.L. (amp 2005)
    18. ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma. (PubMed id 12149228)1, 4, 9 GrA...Guldberg P. (Blood 2002)
    19. Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. (PubMed id 11375976)1, 2, 9 Kishi S.... Lu K.P. (J. Biol. Chem. 2001)
    20. ATM mutations in B-cell chronic lymphocytic leukemia. (PubMed id 9892178)1, 2, 9 Bullrich F.... Croce C.M. (Cancer Res. 1999)
    21. Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy. (PubMed id 17517479)1, 4, 9 Ho A.Y....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2007)
    22. Idiopathic and radiation-induced ocular telangiectasia: the involvement of the ATM gene. (PubMed id 12882767)1, 4, 9 Mauget-FaA?sse M....Hall J. (amp 2003)
    23. Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients. (PubMed id 11606401)1, 4, 9 DAPrk T....Karstens J.H. (Cancer Res. 2001)
    24. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. (PubMed id 10023947)1, 2, 9 Stankovic T.... Taylor A.M.R. (Lancet 1999)
    25. Characterization of ATM gene mutations in 66 ataxia telangiectasia families. (PubMed id 9887333)1, 2, 9 Sandoval N.... Schindler D. (Hum. Mol. Genet. 1999)
    26. New mutations, polymorphisms, and rare variants in the ATM gene detected by a novel SSCP strategy. (PubMed id 10425038)1, 2, 9 Castellvi-Bel S.... Gatti R.A. (Hum. Mutat. 1999)
    27. Enhanced phosphorylation of p53 by ATM in response to DNA damage. (PubMed id 9733514)1, 2, 9 Banin S.... Ziv Y. (Science 1998)
    28. A Ser49Cys variant in the ataxia telangiectasia, mutated, gene that is more common in patients with breast carcinoma compared with population controls. (PubMed id 15042666)1, 4, 9 Buchholz T.A....Story M.D. (Cancer 2004)
    29. Elevated frequency of ATM gene missense mutations in breast cancer relative to ethnically matched controls. (PubMed id 11996792)1, 4, 9 Sommer S.S....Dritschilo A. (Cancer Genet. Cytogenet. 2002)
    30. Association of common ATM variants with familial breast cancer in a South American population. (PubMed id 18433505)1, 4, 9 GonzA!lez-HormazA!bal P....Jara L. (BMC Cancer 2008)
    31. Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk. (PubMed id 17428325)1, 4, 9 Baynes C....Dunning A.M. (Breast Cancer Res. 2007)
    32. ATM missense variant P1054R predisposes to prostate cancer. (PubMed id 17502119)1, 4, 9 Meyer A....Machtens S. (Radiother Oncol 2007)
    33. The ATM missense mutation p.Ser49Cys (c.146C&gt;G) and the risk of breast cancer. (PubMed id 16652348)1, 4, 9 Stredrick D.L....Sigurdson A.J. (Hum. Mutat. 2006)
    34. Two ATM variants and breast cancer risk. (PubMed id 15880680)1, 4, 9 Thompson D....Chenevix-Trench G. (Hum. Mutat. 2005)
    35. ATM sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancer. (PubMed id 15629612)1, 4, 9 Cesaretti J.A....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2005)
    36. ATM polymorphisms as risk factors for prostate cancer development. (PubMed id 15280931)1, 4, 9 AngA"le S....Hall J. (Br. J. Cancer 2004)
    37. The relationship between twenty missense ATM variants and breast cancer risk: the Multiethnic Cohort. (PubMed id 12917204)1, 4, 9 Bretsky P....Henderson B.E. (amp 2003)
    38. ATM-dependent phosphorylation of nibrin in response to radiation exposure. (PubMed id 10802669)1, 2, 9 Gatei M.... Khanna K.K. (Nat. Genet. 2000)
    39. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. (PubMed id 9733515)1, 2, 9 Canman C.E.... Siliciano J.D. (Science 1998)
    40. Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value. (PubMed id 19594747)1, 4, 9 Jardin F....Tilly H. (Br. J. Haematol. 2009)
    41. A nonsense mutation (E1978X) in the ATM gene is associated with breast cancer. (PubMed id 18807267)1, 4, 9 Bogdanova N....DAPrk T. (Breast Cancer Res. Treat. 2009)
    42. ATM allelic variants associated to hereditary breast cancer in 94 Chilean women: susceptibility or ethnic influences? (PubMed id 17351744)1, 4, 9 Tapia T....Carvallo P. (Breast Cancer Res. Treat. 2008)
    43. ATM gene variants in patients with idiopathic perifoveal telangiectasia. (PubMed id 18502988)1, 4, 9 Barbazetto I.A....Allikmets R. (amp 2008)
    44. Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity. (PubMed id 18990028)1, 4, 9 Shin A....Kang D. (Asian Pac. J. Cancer Prev. 2008)
    45. Population-based estimates of breast cancer risks associated with ATM gene variants c.7271T&gt;G and c.1066-6T&gt;G (IVS10-6T&gt;G) from the Breast Cancer Family Registry. (PubMed id 16958054)1, 4, 9 Bernstein J.L....Concannon P. (Hum. Mutat. 2006)
    46. ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapy. (PubMed id 16338099)1, 4, 9 Andreassen C.N....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2006)
    47. ATM missense mutations are frequent in patients with breast cancer. (PubMed id 12935922)1, 4, 9 Sommer S.S....Dritschilo A. (Cancer Genet. Cytogenet. 2003)
    48. Ataxia-telangiectasia without immunodeficiency: novel point mutations within and adjacent to the phosphatidylinositol 3-kinase-like domain. (PubMed id 9450874)1, 2, 9 Toyoshima M.... Takeshita K. (Am. J. Med. Genet. 1998)
    49. Ataxia-telangiectasia: identification and detection of founder-effect mutations in the ATM gene in ethnic populations. (PubMed id 9443866)1, 2, 9 Telatar M.... Gatti R.A. (Am. J. Hum. Genet. 1998)
    50. ATM germline mutations in classical ataxia-telangiectasia patients in the Dutch population. (PubMed id 9792409)1, 2, 9 Broeks A.... van 't Veer L.J. (Hum. Mutat. 1998)
    51. ATM is usually rearranged in T-cell prolymphocytic leukaemia. (PubMed id 9488043)1, 2, 9 Yuille M.A.R....Catovsky D. (Oncogene 1998)
    52. Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression. (PubMed id 9108147)1, 2, 9 Savitsky K.... Rotman G. (Nucleic Acids Res. 1997)
    53. Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia. (PubMed id 9288106)1, 2, 9 Vorechovsky I....Yuille M.A.R. (Nat. Genet. 1997)
    54. ATM mutations in cancer families. (PubMed id 8797579)1, 2, 9 Vorechovsky I.... Hammarstroem L. (Cancer Res. 1996)
    55. Exon-scanning mutation analysis of the ATM gene in patients with ataxia-telangiectasia. (PubMed id 9043869)1, 2, 9 Vorechovsky I.... Hammarstroem L. (Eur. J. Hum. Genet. 1996)
    56. Genomic organization of the ATM locus involved in ataxia- telangiectasia. (PubMed id 8521392)1, 2, 9 Rasio D.... Croce C.M. (Cancer Res. 1995)
    57. Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case-control study. (PubMed id 19626602)1, 4, 9 Zheng Y.L....Harris C.C. (Int. J. Cancer 2010)
    58. ATM germline mutations in women with familial breast cancer and a relative with haematological malignancy. (PubMed id 19404735)1, 4, 9 Paglia L.L....Stoppa-Lyonnet D. (Breast Cancer Res. Treat. 2010)
    59. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. (PubMed id 19286843)1, 4, 9 Akulevich N.M....Yamashita S. (Endocr. Relat. Cancer 2009)
    60. The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features. (PubMed id 19536649)1, 4, 9 Barroso E....Ribas G. (Breast Cancer Res. Treat. 2009)
    61. Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients. (PubMed id 19638463)1, 4, 9 Pugh T.J....Moore R.A. (Clin. Cancer Res. 2009)
    62. Single nucleotide polymorphism D1853N of the ATM gene may alter the risk for breast cancer. (PubMed id 18264724)1, 4, 9 Schrauder M....Fasching P.A. (J. Cancer Res. Clin. Oncol. 2008)
    63. Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy. (PubMed id 18829510)1, 4, 9 Azria D....Rosenstein B.S. (Clin. Cancer Res. 2008)
    64. Risk of cancer by ATM missense mutations in the general population. (PubMed id 18565893)1, 4, 9 Dombernowsky S.L....Nordestgaard B.G. (J. Clin. Oncol. 2008)
    65. Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer. (PubMed id 18381943)1, 4, 9 Okazaki T....Li D. (Clin. Cancer Res. 2008)
    66. Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study. (PubMed id 17428320)1, 4, 9 Broeks A....Van 't Veer L.J. (Breast Cancer Res. 2007)
    67. ATM sequence variants associate with susceptibility to non-small cell lung cancer. (PubMed id 17582598)1, 4, 9 Yang H....Wu X. (Int. J. Cancer 2007)
    68. ATM gene mutations in former uranium miners of SDAG Wismut: a pilot study. (PubMed id 17203191)1, 4, 9 Schneider J....Woitowitz H.J. (Oncol. Rep. 2007)
    69. ATM polymorphism IVS62+60G&gt;A is not associated with disease aggressiveness in prostate cancer. (PubMed id 16765197)1, 4, 9 Browning R.E....Lu B. (Urology 2006)
    70. Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. (PubMed id 16638864)1, 4, 9 Damaraju S....Parliament M. (Clin. Cancer Res. 2006)
    71. Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples. (PubMed id 16966185)1, 4, 9 Andreassen C.N....Overgaard J. (Int. J. Radiat. Biol. 2006)
    72. ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. (PubMed id 15916964)1, 2, 9 Bhoumik A....Ronai Z. (Mol. Cell 2005)
    73. Molecular variants of the ATM gene in Hodgkin's disease in children. (PubMed id 14735203)1, 4, 9 Liberzon E....Zaizov R. (Br. J. Cancer 2004)
    74. Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study. (PubMed id 15084244)1, 4, 9 Bernstein J.L....Thompson W.D. (Breast Cancer Res. 2004)
    75. ATM variants 7271T&gt;G and IVS10-6T&gt;G among women with unilateral and bilateral breast cancer. (PubMed id 14562025)1, 4, 9 Bernstein J.L....Haile R.W. (Br. J. Cancer 2003)
    76. Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effects. (PubMed id 14643952)1, 4, 9 Bremer M....Karstens J.H. (Radiother Oncol 2003)
    77. Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. (PubMed id 12409306)1, 2, 9 Suzuki A....Esumi H. (J. Biol. Chem. 2003)
    78. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. (PubMed id 10839545)1, 2, 9 Wu X.... Weaver D.T. (Nature 2000)
    79. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. (PubMed id 10783165)1, 2, 9 Wang Y.... Qin J. (Genes Dev. 2000)
    80. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. (PubMed id 10766245)1, 2, 9 Lim D.-S....Kastan M.B. (Nature 2000)
    81. The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage. (PubMed id 9050866)1, 2, 9 Brown K.D.... Tagle D.A. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    82. Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. (PubMed id 9150358)1, 2, 9 Watters D.... Lavin M.F. (Oncogene 1997)
    83. Interaction between ATM protein and c-Abl in response to DNA damage. (PubMed id 9168117)1, 2, 9 Shafman T.... Lavin M.F. (Nature 1997)
    84. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. (PubMed id 7792600)1, 2, 9 Savitsky K.... Shiloh Y. (Science 1995)
    85. Genome-wide association study identifies three new melanoma susceptibility loci. (PubMed id 21983787)1, 4 Barrett J.H....Bishop D.T. (Nat. Genet. 2011)
    86. Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia. (PubMed id 20232390)1, 4 Shi J.Y....Chen S.J. (Int. J. Cancer 2011)
    87. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)
    88. Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females. (PubMed id 21187516)1, 4 Wang H.C....Bau D.T. (Anticancer Res. 2010)
    89. A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. (PubMed id 20810650)1, 2 Hurov K.E.... Elledge S.J. (Genes Dev. 2010)
    90. The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis. (PubMed id 20799949)1, 4 Gao L.B....Zhang L. (amp 2010)
    91. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. (PubMed id 20801936)1, 2 Takai H.... Pavletich N.P. (Genes Dev. 2010)
    92. Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer. (PubMed id 20731661)1, 4 Kim M....Park J.Y. (Cancer Sci. 2010)
    93. ATM polymorphisms are associated with risk of radiation-induced pneumonitis. (PubMed id 20171797)1, 4 Zhang L....Wang L. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    94. Interaction between BRCA1/BRCA2 and ATM/ATR associate with breast cancer susceptibility in a Chinese Han population. (PubMed id 20513533)1, 4 Wang K....Song Y. (Cancer Genet. Cytogenet. 2010)
    95. Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. (PubMed id 19714462)1, 4 Loizidou M.A....Kyriacou K. (Breast Cancer Res. Treat. 2010)
    96. Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility. (PubMed id 21108427)1, 4 Bau D.T....Tsai R.Y. (Laryngoscope 2010)
    97. Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk. (PubMed id 21058196)1, 4 Lee S.A....Kang D. (Nutr Cancer 2010)
    98. Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls. (PubMed id 20826828)1, 4 Fletcher O....Peto J. (amp 2010)
    99. Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. (PubMed id 20170971)1, 4 Zschenker O....Borgmann K. (Radiother Oncol 2010)
    100. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    101. Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer. (PubMed id 20177704)1, 4 Bozhanov S.S....Georgieva E.I. (J. Cancer Res. Clin. Oncol. 2010)
    102. ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. (PubMed id 19965871)1, 2 Taira N.... Yoshida K. (J. Biol. Chem. 2010)
    103. Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. (PubMed id 20610542)1, 4 Liu Y....Bondy M.L. (Carcinogenesis 2010)
    104. Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study. (PubMed id 20605201)1, 4 Travis R.C....Lathrop M. (Lancet 2010)
    105. Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. (PubMed id 20427287)1, 2 Kaizuka T.... Mizushima N. (J. Biol. Chem. 2010)
    106. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    107. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (Int. J. Cancer 2010)
    108. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    109. ATM polymorphisms and risk of lung cancer among never smokers. (PubMed id 20004998)1, 4 Lo Y.L....Hsiung C.A. (Lung Cancer 2010)
    110. Toward a comprehensive prognostic scoring system in chronic lymphocytic leukemia based on a combination of genetic parameters. (PubMed id 20552631)1, 4 Haferlach C....Haferlach T. (amp 2010)
    111. DNA repair gene polymorphisms and risk of pancreatic cancer. (PubMed id 19147782)1, 4 Li D....Abbruzzese J.L. (Clin. Cancer Res. 2009)
    112. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    113. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    114. A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (PubMed id 19116388)1, 4 Vineis P....Matullo G. (J. Natl. Cancer Inst. 2009)
    115. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    116. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PubMed id 19351817)1, 4 Blackford A....Hruban R.H. (Cancer Res. 2009)
    117. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    118. A common 9 bp deletion in the ataxia-telangiectasia-mutated gene is not associated with oral cancer. (PubMed id 19661334)1, 4 Spyridonidou S....Vairaktaris E. (Anticancer Res. 2009)
    119. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)1, 4 Kweekel D.M....Guchelaar H.J. (Br. J. Cancer 2009)
    120. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    121. Antaxia-telangiectasia mutated gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers. (PubMed id 19193393)1, 4 Wang Y....Zheng Y. (Sci. Total Environ. 2009)
    122. Functional and computational assessment of missense variants in the ataxia-telangiectasia mutated (ATM) gene: mutations with increased cancer risk. (PubMed id 18634022)1, 4 Mitui M....Gatti R.A. (Hum. Mutat. 2009)
    123. Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. (PubMed id 19584272)1, 4 Rebbeck T.R....Daly M.B. (Cancer Res. 2009)
    124. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    125. Description and validation of high-throughput simultaneous genotyping and mutation scanning by high-resolution melting curve analysis. (PubMed id 19347964)1, 4 Nguyen-Dumont T.... . (Hum. Mutat. 2009)
    126. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (amp 2009)
    127. Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population. (PubMed id 19115993)1, 4 Zhang F....Sham P.C. (BMC Med. Genet. 2008)
    128. Screening for ATM sequence alterations in African-American women diagnosed with breast cancer. (PubMed id 17333338)1, 4 Hirsch A.E....Rosenstein B.S. (Breast Cancer Res. Treat. 2008)
    129. A role for DEAD box 1 at DNA double-strand breaks. (PubMed id 18710941)1, 2 Li L.... Godbout R. (Mol. Cell. Biol. 2008)
    130. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    131. Variants in the ATM gene associated with a reduced risk of contralateral breast cancer. (PubMed id 18701470)1, 4 Concannon P....Bernstein J.L. (Cancer Res. 2008)
    132. Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage &quot;checkpoints&quot; and lung cancer susceptibility. (PubMed id 18451257)1, 4 Hu Z....Shen H. (Clin. Cancer Res. 2008)
    133. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. (PubMed id 18449195)1, 2 Richard D.J.... Khanna K.K. (Nature 2008)
    134. Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions. (PubMed id 18579371)1, 4 Yang H....Wu X. (Eur. J. Cancer 2008)
    135. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    136. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    137. The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer. (PubMed id 19094228)1, 4 Tapper W....Eccles D. (Breast Cancer Res. 2008)
    138. Analysis of variants in DNA damage signalling genes in bladder cancer. (PubMed id 18638378)1, 4 Choudhury A....Kiltie A.E. (BMC Med. Genet. 2008)
    139. Breast cancer incidence and the effect of cigarette smoking in heterozygous carriers of mutations in the ataxia-telangiectasia gene. (PubMed id 18990761)1, 4 Swift M. and Lukin J.L. (amp 2008)
    140. The spectrum of ATM missense variants and their contribution to contralateral breast cancer. (PubMed id 17393301)1, 4 Broeks A....Van 't Veer L.J. (Breast Cancer Res. Treat. 2008)
    141. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility. (PubMed id 17341484)1, 4 Johnson N....Peto J. (Hum. Mol. Genet. 2007)
    142. A common coding variant in CASP8 is associated with breast cancer risk. (PubMed id 17293864)1, 4 Cox A....Easton D.F. (Nat. Genet. 2007)
    143. A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma. (PubMed id 17640065)1, 4 Sipahimalani P....Brooks-Wilson A.R. (Int. J. Cancer 2007)
    144. Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk. (PubMed id 17164260)1, 4 EinarsdA^ttir K....WedrAcn S. (Hum. Mol. Genet. 2007)
    145. This article was published online in error and has been removed by the publisher. (PubMed id 17409195)1, 4 (Hum. Mol. Genet. 2007)
    146. ATMIN defines an NBS1-independent pathway of ATM signalling. (PubMed id 17525732)1, 2 Kanu N. and Behrens A. (EMBO J. 2007)
    147. Two-stage case-control study of common ATM gene variants in relation to breast cancer risk. (PubMed id 17431766)1, 4 Ye C....Zheng W. (Breast Cancer Res. Treat. 2007)
    148. Genetic polymorphisms of ataxia telangiectasia mutated affect lung cancer risk. (PubMed id 16497724)1, 4 Kim J.H....Hong Y.C. (Hum. Mol. Genet. 2006)
    149. ATM variants and cancer risk in breast cancer patients from Southern Finland. (PubMed id 16914028)1, 4 Tommiska J....Nevanlinna H. (BMC Cancer 2006)
    150. ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. (PubMed id 16832357)1, 4 Renwick A....Rahman N. (Nat. Genet. 2006)
    151. ATM haplotypes and breast cancer risk in Jewish high-risk women. (PubMed id 16622469)1, 4 Koren M....Friedman E. (Br. J. Cancer 2006)
    152. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. (PubMed id 16520463)1, 4 Li D....Abbruzzese J.L. (J. Clin. Oncol. 2006)
    153. Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia. (PubMed id 16574953)1, 4 Rudd M.F....Houlston R.S. (Blood 2006)
    154. Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study. (PubMed id 17132159)1, 4 EinarsdA^ttir K....WedrAcn S. (Breast Cancer Res. 2006)
    155. Involvement of novel autophosphorylation sites in ATM activation. (PubMed id 16858402)1, 2 Kozlov S.V.... Lavin M.F. (EMBO J. 2006)
    156. The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. (PubMed id 15680327)1, 2 Park B.-J.... Kim S. (Cell 2005)
    157. TP53-binding protein variants and breast cancer risk: a case-control study. (PubMed id 15987456)1, 4 Frank B....Burwinkel B. (Breast Cancer Res. 2005)
    158. Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. (PubMed id 16086026)1, 2 Kaygun H. and Marzluff W.F. (Nat. Struct. Mol. Biol. 2005)
    159. Involvement of human MOF in ATM function. (PubMed id 15923642)1, 2 Gupta A.... Pandita T.K. (Mol. Cell. Biol. 2005)
    160. Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia. (PubMed id 16167060)1, 4 Meier M....Pieters R. (Leukemia 2005)
    161. Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL. (PubMed id 16014569)1, 4 Austen B....Stankovic T. (Blood 2005)
    162. Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk. (PubMed id 15824150)1, 4 Lee K.M....Kang D. (amp 2005)
    163. TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. (PubMed id 15878096)1, 4 Andreassen C.N....Yarnold J. (Radiother Oncol 2005)
    164. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. (PubMed id 16141325)1, 2 Sun Y.... Price B.D. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    165. Identification of two mutations for ataxia telangiectasia among the Druze community. (PubMed id 15164409)1, 4 Fares F....Lerner A. (Prenat. Diagn. 2004)
    166. Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study. (PubMed id 15217510)1, 4 Tamimi R.M....Hunter D.J. (Breast Cancer Res. 2004)
    167. Breast cancer in female carriers of ATM gene alterations: outcome of adjuvant radiotherapy. (PubMed id 15450731)1, 4 Meyer A....Bremer M. (Radiother Oncol 2004)
    168. Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease. (PubMed id 12969974)1, 4 Takagi M....Mizutani S. (Blood 2004)
    169. Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. (PubMed id 15456891)1, 2 Zhang X....Legerski R.J. (Mol. Cell. Biol. 2004)
    170. Independent mutational events are rare in the ATM gene: haplotype prescreening enhances mutation detection rate. (PubMed id 12815592)1, 4 Mitui M....Gatti R.A. (Hum. Mutat. 2003)
    171. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. (PubMed id 12556884)1, 2 Bakkenist C.J. and Kastan M.B. (Nature 2003)
    172. Effect of germ-line genetic variation on breast cancer survival in a population-based study. (PubMed id 12036913)1, 4 Goode E.L....Pharoah P.P. (Cancer Res. 2002)
    173. Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers. (PubMed id 12473594)1, 4 Offit K....Yahalom J. (Clin. Cancer Res. 2002)
    174. Convergence of the Fanconi anemia and ataxia telangiectasia signaling pathways. (PubMed id 12086603)1, 2 Taniguchi T.... D'Andrea A.D. (Cell 2002)
    175. No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer. (PubMed id 12473176)1, 4 Spurdle A.B....Khanna K. (Breast Cancer Res. 2002)
    176. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. (PubMed id 11418864)1, 2 Bao S.... Wang X.-F. (Nature 2001)
    177. Influence of angiotensin II type 1 receptor polymorphism on hypertension in patients with hypercholesterolemia. (PubMed id 11165203)1, 4 Morisawa T....Hasegawa J. ( international journal of clinical chemistry 2001)
    178. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. (PubMed id 10910365)1, 2 Li S.... Lee W.-H. (Nature 2000)
    179. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. (PubMed id 10973490)1, 2 Matsuoka S.... Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    180. Mutations at the ataxia-telangiectasia locus and clinical phenotypes of A-T patients. (PubMed id 10817650)1, 2 Li A. and Swift M. (Am. J. Med. Genet. 2000)
    181. Missense mutations at ATM gene and cancer risk. (PubMed id 10217116)1, 2 Vorechovsky I.... Doerk T. (Lancet 1999)
    182. Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer. (PubMed id 10534763)1, 2 Izatt L.... Solomon E. (Genes Chromosomes Cancer 1999)
    183. Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. (PubMed id 10500142)1, 2 Smith G.C.M....Jackson S.P. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    184. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. (PubMed id 10550055)1, 2 Cortez D.... Elledge S.J. (Science 1999)
    185. Rapid and efficient ATM mutation detection by fluorescent chemical cleavage of mismatch: identification of four novel mutations. (PubMed id 10234507)1, 2 Izatt L.... Solomon E. (Eur. J. Hum. Genet. 1999)
    186. ATM mutations in patients with ataxia telangiectasia screened by a hierarchical strategy. (PubMed id 9711876)1, 2 Sasaki T.... Hayashi K. (Hum. Mutat. 1998)
    187. ATM binds to beta-adaptin in cytoplasmic vesicles. (PubMed id 9707615)1, 2 Lim D.-S.... Kastan M.B. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    188. Strategies for mutational analysis of the large multiexon ATM gene using high-density oligonucleotide arrays. (PubMed id 9872980)1, 2 Hacia J.G.... Collins F.S. (Genome Res. 1998)
    189. A double missense mutation in the ATM gene of a Dutch family with ataxia telangiectasia. (PubMed id 9521587)1, 2 van Belzen M.J.... van den Heuvel L.P.W.J. (Hum. Genet. 1998)
    190. ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer. (PubMed id 9463314)1, 2 Stankovic T.... Taylor A.M.R. (Am. J. Hum. Genet. 1998)
    191. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. (PubMed id 9766667)1, 2 Sarkaria J.N....Abraham R.T. (Cancer Res. 1998)
    192. Ataxia-telangiectasia in the Japanese population: identification of R1917X, W2491R, R2909G, IVS33+2T-->A, and 7883del5, the latter two being relatively common mutations. (PubMed id 9792410)1, 2 Fukao T.... Kondo N. (Hum. Mutat. 1998)
    193. ATM gene product phosphorylates I kappa B-alpha. (PubMed id 8988033)1, 2 Jung M.... Dritschilo A. (Cancer Res. 1997)
    194. Biallelic mutations in the ATM gene in T-prolymphocytic leukemia. (PubMed id 9334731)1, 2 Stilgenbauer S.... Doehner H. (Nat. Med. 1997)
    195. Predominance of null mutations in ataxia-telangiectasia. (PubMed id 8845835)1, 2 Gilad S....Bar-Shira A. (Hum. Mol. Genet. 1996)
    196. Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia. (PubMed id 8789452)1, 2 Byrd P.J.... Taylor A.M.R. (Hum. Mol. Genet. 1996)
    197. A high frequency of distinct ATM gene mutations in ataxia- telangiectasia. (PubMed id 8808599)1, 2 Wright J....Concannon P. (Am. J. Hum. Genet. 1996)
    198. New mutations in the ataxia telangiectasia gene. (PubMed id 8698354)1, 2 Baumer A.... Schindler D. (Hum. Genet. 1996)
    199. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. (PubMed id 8589678)1, 2 Savitsky K.... Rotman G. (Hum. Mol. Genet. 1995)
    200. ATM alterations in childhood non-Hodgkin lymphoma. (PubMed id 16631465)1, 9 Gumy-Pause F....Sappino A.P. (Cancer Genet. Cytogenet. 2006)
    201. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. (PubMed id 15713674)1, 9 Fernandes N....Price B.D. (J. Biol. Chem. 2005)
    202. Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity. (PubMed id 16426903)1, 9 Goldstine J.V....Marahrens Y. (DNA Repair (Amst.) 2006)
    203. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. (PubMed id 16603769)1, 9 Jiang X....Price B.D. (J. Biol. Chem. 2006)
    204. Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. (PubMed id 15234984)1, 9 Cerosaletti K. and Concannon P. (J. Biol. Chem. 2004)
    205. Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1. (PubMed id 15345673)1, 9 Shahrabani-Gargir L....Werner H. (Endocrinology 2004)
    206. Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer. (PubMed id 11805335)1, 9 Scott S.P....Lavin M.F. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    207. Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients. (PubMed id 18573109)1, 9 Austen B....Taylor A.M. (Br. J. Haematol. 2008)
    208. [Prognostic significance of p53 and ATM gene deletion in patients with chronic lymphocytic leukemia]. (PubMed id 19035176)1, 9 Xu W....Qiu H.X. (Zhonghua Xue Ye Xue Za Zhi 2008)
    209. Prognostic significance of ATM and TP53 deletions in Chinese patients with chronic lymphocytic leukemia. (PubMed id 18035414)1, 9 Xu W....Qiu H.X. (Leuk. Res. 2008)
    210. ATM gene expression is associated with differentiation and angiogenesis in infiltrating breast carcinomas. (PubMed id 16329039)1, 9 Cuatrecasas M....Fernandez P.L. (Histol. Histopathol. 2006)
    211. Active role for nibrin in the kinetics of atm activation. (PubMed id 16478990)1, 9 Cerosaletti K....Concannon P. (Mol. Cell. Biol. 2006)
    212. ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. (PubMed id 15173573)1, 9 Irarrazabal C.E....Ferraris J.D. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    213. Dominant negative ATM mutations in breast cancer families. (PubMed id 11830610)1, 9 Chenevix-Trench G....Khanna K.K. (J. Natl. Cancer Inst. 2002)
    214. ATM activation is accompanied with earlier stages of prostate tumorigenesis. (PubMed id 16997395)1, 9 Fan C....Tang D. (Biochim. Biophys. Acta 2006)
    215. DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. (PubMed id 16293623)1, 9 Dodson G.E. and Tibbetts R.S. (J. Biol. Chem. 2006)
    216. Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis. (PubMed id 16184611)1, 9 Kurose A....Darzynkiewicz Z. (Cytometry A 2005)
    217. Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. (PubMed id 15048089)1, 9 HorejsA- Z....Bartek J. (Oncogene 2004)
    218. ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity. (PubMed id 14695186)1, 9 AngA"le S....Hall J. (Cancer Res. 2003)
    219. [ATM and Cancer]. (PubMed id 12513844)1, 9 Tang Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2002)
    220. Localization of a portion of extranuclear ATM to peroxisomes. (PubMed id 10567403)1, 9 Watters D....Lavin M.F. (J. Biol. Chem. 1999)
    221. Aven-dependent activation of ATM following DNA damage. (PubMed id 18571408)1, 9 Guo J.Y....Kornbluth S. (Curr. Biol. 2008)
    222. Characterization of an NBS1 C-terminal peptide that can inhibit ataxia telangiectasia mutated (ATM)-mediated DNA damage responses and enhance radiosensitivity. (PubMed id 17507690)1, 9 Cariveau M.J....Xu B. (Mol. Pharmacol. 2007)
    223. ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis. (PubMed id 16426422)1, 9 Tanaka T....Darzynkiewicz Z. (Cell Prolif. 2006)
    224. Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. (PubMed id 15837784)1, 9 Truman J.P....Haimovitz-Friedman A. (J. Biol. Chem. 2005)
    225. Cancer risk according to type and location of ATM mutation in ataxia-telangiectasia families. (PubMed id 15390180)1, 9 Cavaciuti E....Andrieu N. (amp 2005)
    226. The ATM gene is a target for epigenetic silencing in locally advanced breast cancer. (PubMed id 15516988)1, 9 Vo Q.N....Brown K.D. (Oncogene 2004)
    227. Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. (PubMed id 14871926)2, 9 Ali A....Wang X.F. (amp 2004)
    228. Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase. (PubMed id 10713094)1, 9 Chan D.W....Lees-Miller S.P. (J. Biol. Chem. 2000)
    229. Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: a novel mutation target of microsatellite instability. (PubMed id 10738255)1, 9 Ejima Y....Sasaki M.S. (Int. J. Cancer 2000)
    230. 53BP1 promotes ATM activity through direct interactions with the MRN complex. (PubMed id 20010693)1, 9 Lee J.H....Paull T.T. (EMBO J. 2010)
    231. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. (PubMed id 19779458)1, 9 Beucher A....LAPbrich M. (EMBO J. 2009)
    232. ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. (PubMed id 19816404)1, 9 Cheng Q.... Chen J. (EMBO J. 2009)
    233. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. (PubMed id 17486112)1, 9 Berkovich E....Kastan M.B. (Nat. Cell Biol. 2007)
    234. Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence. (PubMed id 17623063)1, 9 Edvardsen H....rresen-Dale A.L. (Radiat Oncol 2007)
    235. Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis. (PubMed id 16582589)1, 9 Hong S....Johnson D.G. (Cell Cycle 2006)
    236. The combined status of ATM and p53 link tumor development with therapeutic response. (PubMed id 19608766)1, 9 Jiang H....Hemann M.T. (amp 2009)
    237. Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation. (PubMed id 18802408)1, 9 Zhao H....Darzynkiewicz Z. (Cell Cycle 2008)
    238. MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control. (PubMed id 17694070)1, 9 Wu Y....Zhu X.D. (amp 2007)
    239. The involvement of ataxia-telangiectasia mutated protein activation in nucleotide excision repair-facilitated cell survival with cisplatin treatment. (PubMed id 16849332)1, 9 Colton S.L....Wang G. (J. Biol. Chem. 2006)
    240. Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. (PubMed id 16533773)1, 9 Grabsch H....Mueller W. (Clin. Cancer Res. 2006)
    241. Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses. (PubMed id 12958068)1, 9 Stankovic T....Taylor A.M. (Blood 2004)
    242. ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. (PubMed id 15539948)1, 9 Davalos A.R....Campisi J. (Cell Cycle 2004)
    243. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. (PubMed id 15064416)1, 9 Lee J.-H. and Paull T.T. (Science 2004)
    244. ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. (PubMed id 11875057)1, 9 Saito S....Anderson C.W. (J. Biol. Chem. 2002)
    245. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. (PubMed id 11278964)1, 9 Gatei M....Khanna K.K. (J. Biol. Chem. 2001)
    246. The ATM gene and susceptibility to breast cancer: analysis of 38 breast tumors reveals no evidence for mutation. (PubMed id 8665503)2, 9 Vorechovsky I.... Negrini M. (Cancer Res. 1996)
    247. Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences. (PubMed id 20123963)1, 9 Kodama M....Taya Y. (Mol. Cell. Biol. 2010)
    248. Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia. (PubMed id 19586936)1, 9 Krieger D....Burkhardt B. (Haematologica 2010)
    249. ATM-mediated transcriptional elevation of prion in response to copper-induced oxidative stress. (PubMed id 19064990)1, 9 Qin K....Zhao R.Y. (J. Biol. Chem. 2009)
    250. S1219 residue of 53BP1 is phosphorylated by ATM kinase upon DNA damage and required for proper execution of DNA damage response. (PubMed id 18996087)1, 9 Lee H....Lee C.H. (Biochem. Biophys. Res. Commun. 2009)
    251. PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo. (PubMed id 19029835)1, 9 Truman J.P....Haimovitz-Friedman A. (amp 2009)
    252. Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and p53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers. (PubMed id 18642075)1, 9 Kontorovich T....Friedman E. (Breast Cancer Res. Treat. 2009)
    253. Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. (PubMed id 19401701)1, 9 Sahu R.P....Srivastava S.K. (Br. J. Cancer 2009)
    254. Founder effects for ATM gene mutations in Italian Ataxia Telangiectasia families. (PubMed id 19691550)1, 9 Chessa L....Dallapiccola B. (Ann. Hum. Genet. 2009)
    255. Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation. (PubMed id 19805520)1, 9 Ray A....Wani A.A. (Mol. Cell. Biol. 2009)
    256. ATM and Chk2 kinase target the p53 cofactor Strap. (PubMed id 18833288)1, 9 Adams C.J....La Thangue N.B. (EMBO Rep. 2008)
    257. The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. (PubMed id 18667510)1, 9 Ariumi Y....Kato N. (J. Virol. 2008)
    258. ATM mutations in Italian families with ataxia telangiectasia include two distinct large genomic deletions. (PubMed id 16941484)1, 9 Cavalieri S....Brusco A. (Hum. Mutat. 2006)
    259. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. (PubMed id 16163388)1, 9 Chen L.... Chen J. (EMBO J. 2005)
    260. ATM mutations, haplotype analysis, and immunological status of Russian patients with ataxia telangiectasia. (PubMed id 15880721)1, 9 Birrell G.W....Lavin M.F. (Hum. Mutat. 2005)
    261. ATM gene and lymphoid malignancies. (PubMed id 14628072)1, 9 Gumy-Pause F....Sappino A.P. (Leukemia 2004)
    262. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). (PubMed id 15149599)1, 9 Herbig U....Sedivy J.M. (Mol. Cell 2004)
    263. Germ-line ATM gene alterations are associated with susceptibility to sporadic T-cell acute lymphoblastic leukemia in children. (PubMed id 14695997)4, 9 Liberzon E....Zaizov R. (amp 2004)
    264. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. (PubMed id 15361830)1, 9 Buscemi G....Delia D. (Oncogene 2004)
    265. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. (PubMed id 11146653)1, 9 Yang D.Q. and Kastan M.B. (Nat. Cell Biol. 2000)
    266. Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. (PubMed id 10744722)1, 9 Zhou B.B....Khanna K.K. (J. Biol. Chem. 2000)
    267. Mutations of the ATM gene detected in Japanese ataxia-telangiectasia patients: possible preponderance of the two founder mutations 4612del165 and 7883del5. (PubMed id 9600235)1, 9 Ejima Y. and Sasaki M.S. (Hum. Genet. 1998)
    268. DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response. (PubMed id 20338046)1, 9 Dejeux E....Tost J. (Mol. Cancer 2010)
    269. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. (PubMed id 19597488)1, 9 Rodier F....Campisi J. (Nat. Cell Biol. 2009)
    270. DNA-damage response, survival and differentiation in vitro of a human neural stem cell line in relation to ATM expression. (PubMed id 19229246)1, 9 Carlessi L....Delia D. (Cell Death Differ. 2009)
    271. Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. (PubMed id 19153073)1, 9 Flanagan J.M....Petronis A. (Hum. Mol. Genet. 2009)
    272. Pro-apoptotic function of checkpoint kinase-2 in syncytia elicited by the HIV-1 envelope. (PubMed id 19177012)1, 9 SAcror C....Kroemer G. (Cell Cycle 2009)
    273. Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis. (PubMed id 19028473)1, 9 Li W....Zhang J. (Chem. Biol. Interact. 2009)
    274. DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases. (PubMed id 19071136)1, 9 Yajima H....Chen B.P. (J. Mol. Biol. 2009)
    275. ATM is required for rapid degradation of cyclin D1 in response to gamma-irradiation. (PubMed id 19071090)1, 9 Choo D.W....Kim S.S. (Biochem. Biophys. Res. Commun. 2009)
    276. Immunodeficiency in ataxia telangiectasia is correlated strongly with the presence of two null mutations in the ataxia telangiectasia mutated gene. (PubMed id 18505428)1, 9 Staples E.R....Davies E.G. (Clin. Exp. Immunol. 2008)
    277. Statins use a novel Nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. (PubMed id 18723444)1, 9 Mahmoudi M....Bennett M. (Circ. Res. 2008)
    278. NBS1 prevents chromatid-type aberrations through ATM-dependent interactions with SMC1. (PubMed id 18763866)1, 9 Antoccia A....Komatsu K. (Radiat. Res. 2008)
    279. ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells. (PubMed id 17932249)1, 9 Stagni V....BarilA D. (Blood 2008)
    280. Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3. (PubMed id 18442975)1, 9 Luo H....Qin J. (J. Biol. Chem. 2008)
    281. The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer. (PubMed id 17982490)1, 9 Tommiska J....Nevanlinna H. (Oncogene 2008)
    282. Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: implications for carcinogenesis. (PubMed id 18224251)1, 9 Yamamoto K....Liu J.M. (Mol. Med. 2008)
    283. Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer. (PubMed id 17928013)1, 9 Kang B....Lu Y.Y. (Mutat. Res. 2008)
    284. ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. (PubMed id 17875758)1, 9 Joshi A.D....Joshi S.S. (Clin. Cancer Res. 2007)
    285. Our cells get stressed too! Implications for human disease. (PubMed id 17537652)1, 9 Kastan M.B. (amp 2007)
    286. Translocations as a mechanism for homozygous deletion of 13q14 and loss of the ATM gene in a patient with B-cell chronic lymphocytic leukemia. (PubMed id 17350468)1, 9 Herholz H....Haferlach C. (Cancer Genet. Cytogenet. 2007)
    287. The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase. (PubMed id 17593081)1, 9 Treilleux I....Hall J. (Histopathology 2007)
    288. Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. (PubMed id 17409407)1, 9 Hunt C.R....Pandita T.K. (Cancer Res. 2007)
    289. Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks. (PubMed id 17634426)1, 9 Rao V.A....Pommier Y. (Mol. Cancer Res. 2007)
    290. Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM. (PubMed id 17510082)1, 9 Luciani M.G....Gasche C. (Carcinogenesis 2007)
    291. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. (PubMed id 16872911)1, 9 Rai R....Lin S.Y. (Cancer Cell 2006)
    292. Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression. (PubMed id 16636671)1, 9 Zhang J....Tang D. (Oncogene 2006)
    293. 2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX. (PubMed id 16628006)1, 9 Tanaka T....Darzynkiewicz Z. (Cell Cycle 2006)
    294. Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. (PubMed id 16943440)1, 9 Ho G.P....D'Andrea A.D. (Mol. Cell. Biol. 2006)
    295. Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. (PubMed id 17030982)1, 9 Dellaire G....Bazett-Jones D.P. (J. Cell Biol. 2006)
    296. Mutation analysis of the ATM gene in two Chinese patients with ataxia telangiectasia. (PubMed id 16380133)1, 9 Jiang H....Dai H. (J. Neurol. Sci. 2006)
    297. Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. (PubMed id 15546863)1, 9 Viniegra J.G....SA!nchez-Prieto R. (J. Biol. Chem. 2005)
    298. Cancer risks and mortality in heterozygous ATM mutation carriers. (PubMed id 15928302)1, 9 Thompson D....Easton D.F. (J. Natl. Cancer Inst. 2005)
    299. Five haplotypes account for fifty-five percent of ATM mutations in Brazilian patients with ataxia telangiectasia: seven new mutations. (PubMed id 15039971)1, 9 Coutinho G....Gatti R.A. (Am. J. Med. Genet. A 2004)
    300. ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. (PubMed id 15226443)1, 9 Luo Y....Lin W.C. (Mol. Cell. Biol. 2004)
    301. A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. (PubMed id 14744762)1, 9 KA1hne M....LAPbrich M. (Cancer Res. 2004)
    302. Adult-onset ataxia telangiectasia due to ATM 5762ins137 mutation homozygosity. (PubMed id 15174027)1, 9 Sutton I.J....Taylor A.M. (Ann. Neurol. 2004)
    303. ATM protein overexpression in prostate tumors: possible role in telomere maintenance. (PubMed id 14983937)1, 9 AngA"le S....Hall J. (Am. J. Clin. Pathol. 2004)
    304. Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. (PubMed id 15456759)1, 9 Jowsey P.A.... Rouse J. (J. Biol. Chem. 2004)
    305. Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. (PubMed id 15024084)1, 9 Rogoff H.A....Kowalik T.F. (Mol. Cell. Biol. 2004)
    306. Functional consequences of sequence alterations in the ATM gene. (PubMed id 15279808)1, 9 Lavin M.F....Chen P. (DNA Repair (Amst.) 2004)
    307. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. (PubMed id 15574327)1, 9 Riballo E.... Loebrich M. (Mol. Cell 2004)
    308. Nonclassical splicing mutations in the coding and noncoding regions of the ATM Gene: maximum entropy estimates of splice junction strengths. (PubMed id 14695534)1, 9 Eng L....Gatti R.A. (Hum. Mutat. 2004)
    309. The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. (PubMed id 15279777)1, 9 Abraham R.T. (DNA Repair (Amst.) 2004)
    310. Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase. (PubMed id 15280449)1, 9 Yuan J.H....Ferris D.K. (Mol. Cancer Res. 2004)
    311. Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. (PubMed id 15510216)1, 9 Goodarzi A.A....Khanna K.K. (EMBO J. 2004)
    312. Functional consequences of ATM sequence variants for chromosomal radiosensitivity. (PubMed id 15101044)1, 9 GutiAcrrez-EnrA-quez S....Hall J. (amp 2004)
    313. Suppression of tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. (PubMed id 12955071)1, 9 Krause D.R.... Khanna K. (Oncogene 2003)
    314. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. (PubMed id 12697768)1, 9 Ward I.M.... Chen J. (J. Biol. Chem. 2003)
    315. ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation. (PubMed id 12926986)1, 9 Heinloth A.N....Paules R.S. (Radiat. Res. 2003)
    316. A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. (PubMed id 12773400)1, 9 Foray N....Jeggo P. (EMBO J. 2003)
    317. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. (PubMed id 12519769)1, 9 Hammond E.M....Giaccia A.J. (J. Biol. Chem. 2003)
    318. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. (PubMed id 12676583)1, 9 Soerensen C.S.... Lukas J. (Cancer Cell 2003)
    319. ATM and related protein kinases: safeguarding genome integrity. (PubMed id 12612651)1, 9 Shiloh Y. (Nat. Rev. Cancer 2003)
    320. ATM gene mutations are not involved in medulloblastoma in children. (PubMed id 14553952)1, 9 Liberzon E....Zaizov R. (Cancer Genet. Cytogenet. 2003)
    321. Contributions of ATM mutations to familial breast and ovarian cancer. (PubMed id 12810666)1, 9 Thorstenson Y.R....Oefner P.J. (Cancer Res. 2003)
    322. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. (PubMed id 11877376)1, 9 Kim S.T....Kastan M.B. (amp 2002)
    323. Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM. (PubMed id 12034743)1, 9 Beamish H....Lavin M.F. (J. Biol. Chem. 2002)
    324. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S- phase checkpoint. (PubMed id 11877377)1, 9 Yazdi P.T.... Qin J. (Genes Dev. 2002)
    325. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. (PubMed id 12234250)1, 9 Sapkota G.P....Alessi D.R. (Biochem. J. 2002)
    326. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. (PubMed id 11756551)1, 9 Yamane K....Chen J. (Mol. Cell. Biol. 2002)
    327. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. (PubMed id 11114888)1, 9 Tibbetts R.S.... Abraham R.T. (Genes Dev. 2000)
    328. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. (PubMed id 10839544)1, 9 Zhao S.... Lee E.Y.-H.P. (Nature 2000)
    329. Ataxia-telangiectasia: founder effect among north African Jews. (PubMed id 8968760)1, 9 Gilad S....Shiloh Y. (Hum. Mol. Genet. 1996)
    330. MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated. (PubMed id 24211747)1 Guo P....Mao Q. (Exp. Cell Res. 2014)
    331. Ataxia-telangiectasia-mutated protein expression with microsatellite instability in gastric cancer as prognostic marker. (PubMed id 23649938)1 Kim J.W....Bang Y.J. (Int. J. Cancer 2014)
    332. DMAP1 is an essential regulator of ATM activity and function. (PubMed id 23318425)1 Penicud K. and Behrens A. (Oncogene 2014)
    333. ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer. (PubMed id 24195511)1 Paulikova S....Beranek M. (Neoplasma 2014)
    334. Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer? (PubMed id 22894650)1 Abdel-Fatah T....Madhusudan S. (amp 2013)
    335. Molecular defects in Moroccan patients with ataxia-telangiectasia. (PubMed id 23322442)1 Jeddane L....Bellaoui H. (Neuromolecular Med. 2013)
    336. KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. (PubMed id 23708966)1 Kaidi A. and Jackson S.P. (Nature 2013)
    337. EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia. (PubMed id 24162653)1 Li J....Herrup K. (Nat. Neurosci. 2013)
    338. Ataxia telangiectasia presenting as dopa-responsive cervical dystonia. (PubMed id 23946315)1 Charlesworth G....Bhatia K.P. (Neurology 2013)
    339. The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line. (PubMed id 23555296)1 Muraki K....Murnane J.P. (PLoS Genet. 2013)
    340. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. (PubMed id 23878245)1 Tripathi D.N....Wogan G.N. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    341. DNA-dependent Protein Kinase Regulates DNA End Resection in Concert with Mre11-Rad50-Nbs1 (MRN) and Ataxia Telangiectasia-mutated (ATM). (PubMed id 24220101)1 Zhou Y. and Paull T.T. (J. Biol. Chem. 2013)
    342. Functional proteomics analysis to study ATM dependent signaling in response to ionizing radiation. (PubMed id 23642045)1 Cheema A.K....Dritschilo A. (Radiat. Res. 2013)
    343. ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair. (PubMed id 23438602)1 Somyajit K....Nagaraju G. (Mol. Cell. Biol. 2013)
    344. Effects of ataxia telangiectasia mutated (ATM) genotypes and smoking habits on lung cancer risk in Taiwan. (PubMed id 24023351)1 Hsia T.C....Bau D.T. (Anticancer Res. 2013)
    345. Modulation of cellular senescence in fibroblasts and dermal papillae cells in vitro. (PubMed id 23578831)1 Gruber J.V....Holtz R. (J Cosmet Sci 2013)
    346. ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis. (PubMed id 23907539)1 Yoshiyama K.O....Umeda M. (EMBO Rep. 2013)
    347. Artemis-dependent DNA double-strand break formation at stalled replication forks. (PubMed id 23465063)1 Unno J....Mizutani S. (Cancer Sci. 2013)
    348. ATM release at resected double-strand breaks provides heterochromatin reconstitution to facilitate homologous recombination. (PubMed id 23935532)1 Geuting V....LAPbrich M. (PLoS Genet. 2013)
    349. ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication. (PubMed id 23592994)1 Sowd G.A....Fanning E. (PLoS Pathog. 2013)
    350. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. (PubMed id 23486281)1 Shiloh Y. and Ziv Y. (Nat. Rev. Mol. Cell Biol. 2013)
    351. Deep-intronic ATM mutation detected by genomic resequencing and corrected in vitro by antisense morpholino oligonucleotide (AMO). (PubMed id 23211698)1 Cavalieri S....Brusco A. (Eur. J. Hum. Genet. 2013)
    352. DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair. (PubMed id 22797063)1 Serrano M.A....Zou Y. (Oncogene 2013)
    353. Concordance of ATM (ataxia telangiectasia mutated) immunohistochemistry between biopsy or metastatic tumor samples and primary tumors in gastric cancer patients. (PubMed id 23328638)1 Kim H.S....Kim W.H. (Pathobiology 2013)
    354. Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians. (PubMed id 22960875)1 Piaceri I....Nacmias B. (Neurol. Sci. 2013)
    355. Identification of ATM mutations in Korean siblings with ataxia-telangiectasia. (PubMed id 23667852)1 Huh H.J....Lee P.H. (Ann Lab Med 2013)
    356. Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-I_B pathway. (PubMed id 23776433)1 Tang Z.P....Wang E.H. (PLoS ONE 2013)
    357. Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. (PubMed id 23440242)1 Ambrose M. and Gatti R.A. (Blood 2013)
    358. NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks. (PubMed id 23146902)1 Wen J....Concannon P. (Oncogene 2013)
    359. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. (PubMed id 23703321)1 New M....La Thangue N.B. (Cell Death Differ. 2013)
    360. The PIM-2 kinase is an essential component of the ultraviolet damage response that acts upstream to E2F-1 and ATM. (PubMed id 23760264)1 Zirkin S....Don J. (J. Biol. Chem. 2013)
    361. ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. (PubMed id 23154078)1 Xiong H....Wei Q. (Int. J. Radiat. Oncol. Biol. Phys. 2013)
    362. ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells. (PubMed id 23626666)1 Alagoz M....El-Khamisy S.F. (PLoS ONE 2013)
    363. MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. (PubMed id 23437304)1 Wu C.W....Yu J. (PLoS ONE 2013)
    364. Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. (PubMed id 23686257)1 Zhang Z....Yuan C.S. (Int. J. Oncol. 2013)
    365. The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation. (PubMed id 23593005)1 Hong S. and Laimins L.A. (PLoS Pathog. 2013)
    366. Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts. (PubMed id 22770119)1 Prasad R.Y....Fry R.C. (Nanotoxicology 2013)
    367. ATM polymorphism is associated with low risk myelodysplastic syndrome. (PubMed id 23246256)1 Ribeiro H.L....Pinheiro R.F. (DNA Repair (Amst.) 2013)
    368. The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. (PubMed id 23468639)1 Wang H....Wu X. (PLoS Genet. 2013)
    369. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. (PubMed id 23230272)1 Yan Q.... Shipp M.A. (Mol. Cell. Biol. 2013)
    370. HPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition. (PubMed id 23706308)1 Wallace N.A....Galloway D.A. (Virology 2013)
    371. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. (PubMed id 23847781)1 Shiloh Y. and Ziv Y. (Nat. Rev. Mol. Cell Biol. 2013)
    372. Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. (PubMed id 23851489)1 Velimezi G....Gorgoulis V.G. (Nat. Cell Biol. 2013)
    373. ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response. (PubMed id 23696749)1 Martin N.T....Hu H. (PLoS Genet. 2013)
    374. Ataxia telangiectasia mutated impacts insulin-like growth factor 1 signalling in skeletal muscle. (PubMed id 22941977)1 Ching J.K....Fisher J.S. (Exp. Physiol. 2013)
    375. Exome sequencing identifies nonsegregating nonsense ATM and PALB2 variants in familial pancreatic cancer. (PubMed id 23561644)1 Grant R.C....Gallinger S. (Hum. Genomics 2013)
    376. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    377. Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation. (PubMed id 23405218)1 Tang J....Yang X. (PLoS ONE 2013)
    378. ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation. (PubMed id 23620409)1 Biddlestone-Thorpe L....Valerie K. (Clin. Cancer Res. 2013)
    379. The inhibition of HIF-2I+ on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation. (PubMed id 23333640)1 Pang Y....Liu Q. (Toxicol. Lett. 2013)
    380. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. (PubMed id 23525106)1 Lee J.H....Paull T.T. (J. Biol. Chem. 2013)
    381. Ataxia-telangiectasia group D complementing gene (ATDC) upregulates matrix metalloproteinase 9 (MMP-9) to promote lung cancer cell invasion by activating ERK and JNK pathways. (PubMed id 23681803)1 Tang Z.P....Wang E.H. (Tumour Biol. 2013)
    382. Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor. (PubMed id 23163762)1 Tamaichi H....Takagi M. (Cancer Sci. 2013)
    383. rs189037, a functional variant in ATM gene promoter, is associated with idiopathic nonobstructive azoospermia. (PubMed id 23993922)1 Li Z....Ni Y. (Fertil. Steril. 2013)
    384. TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q. (PubMed id 22875623)1 Garding A....Mertens D. (Haematologica 2013)
    385. ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage. (PubMed id 23343766)1 Moumen A....Jackson S.P. (Cell Cycle 2013)
    386. Novel mutation in the ATM gene in a Malian family with ataxia telangiectasia. (PubMed id 23142947)1 LandourAc G....Fischbeck K.H. (J. Neurol. 2013)
    387. Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control. (PubMed id 22370485)1 Golding S.E....Valerie K. (Cell Cycle 2012)
    388. Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage. (PubMed id 21986843)1 Britt-Compton B....Baird D.M. (Leukemia 2012)
    389. Loss of ATM kinase activity leads to embryonic lethality in mice. (PubMed id 22869595)1 Daniel J.A....Nussenzweig A. (J. Cell Biol. 2012)
    390. ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres. (PubMed id 22842784)1 Thanasoula M....Tarsounas M. (EMBO J. 2012)
    391. Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer. (PubMed id 22420423)1 Knappskog S....nning P.E. (Breast Cancer Res. 2012)
    392. Tcl1 interacts with Atm and enhances NF-I_B activation in hematologic malignancies. (PubMed id 22065599)1 Gaudio E....Croce C.M. (Blood 2012)
    393. A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts. (PubMed id 22453232)1 van Leeuwen N....Pearson E.R. (Diabetologia 2012)
    394. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    395. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. (PubMed id 22213803)1 Hao Z....Mak T.W. (J. Exp. Med. 2012)
    396. Redundant and nonredundant functions of ATM and H2AX in I+I^ T-lineage lymphocytes. (PubMed id 22730535)1 Yin B....Bassing C.H. (J. Immunol. 2012)
    397. Computational refinement of functional single nucleotide polymorphisms associated with ATM gene. (PubMed id 22529920)1 George Priya Doss C. and Rajith B. (PLoS ONE 2012)
    398. Gene-gene interactions in breast cancer susceptibility. (PubMed id 22072393)1 Turnbull C....Rahman N. (Hum. Mol. Genet. 2012)
    399. Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. (PubMed id 22184063)1 Kim K....An W. (Mol. Cell. Biol. 2012)
    400. Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. (PubMed id 22464731)1 Wu J....Lin H.K. (Mol. Cell 2012)
    401. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    402. Lower expression of ATM and gene deletion is more frequent in adrenocortical carcinomas than adrenocortical adenomas. (PubMed id 22311173)1 Ye J....Ning G. (Endocrine 2012)
    403. Presence of ATM protein and residual kinase activity correlates with the phenotype in ataxia-telangiectasia: a genotype-phenotype study. (PubMed id 22213089)1 Verhagen M.M....Willemsen M.A. (Hum. Mutat. 2012)
    404. Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor I_ light chain enhancer of activated B cells (NFI_B) signaling controls basal and DNA damage-induced transglutaminase 2 expression. (PubMed id 22493284)1 Ai L....Brown K.D. (J. Biol. Chem. 2012)
    405. Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in I^-adrenergic receptor-stimulated apoptosis. (PubMed id 22179422)1 Foster C.R....Singh K. (Exp. Physiol. 2012)
    406. Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia. (PubMed id 22952040)1 Ouillette P....Malek S.N. (amp 2012)
    407. Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells. (PubMed id 23272087)1 Chiu Y.T....Ling M.T. (PLoS ONE 2012)
    408. Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial: blockade at the level of p21 is associated with short response duration. (PubMed id 22675167)1 Lin K....Pettitt A.R. (Clin. Cancer Res. 2012)
    409. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    410. Dexamethasone partially rescues ataxia telangiectasia-mutated (ATM) deficiency in ataxia telangiectasia by promoting a shortened protein variant retaining kinase activity. (PubMed id 23055520)1 Menotta M....Magnani M. (J. Biol. Chem. 2012)
    411. Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial. (PubMed id 23091097)1 Skowronska A....Stankovic T. (J. Clin. Oncol. 2012)
    412. ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis. (PubMed id 22362778)1 Gamper A.M....Bakkenist C.J. (J. Biol. Chem. 2012)
    413. O-GlcNAc modification affects the ATM-mediated DNA damage response. (PubMed id 22759405)1 Miura Y....Endo T. (Biochim. Biophys. Acta 2012)
    414. Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint. (PubMed id 22123827)1 Lee A.Y....Wu X. (J. Biol. Chem. 2012)
    415. ATM mutations in patients with hereditary pancreatic cancer. (PubMed id 22585167)1 Roberts N.J....Klein A.P. (Cancer Discov 2012)
    416. FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. (PubMed id 22893124)1 Chung Y.M....Hu M.C. (Nat Commun 2012)
    417. INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. (PubMed id 22508697)1 Morris C....Jalinot P. (Cancer Res. 2012)
    418. Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells. (PubMed id 22406215)1 Talukder K.A....Nur-E-Kamal A. (Microb. Pathog. 2012)
    419. Functional characterization and targeted correction of ATM mutations identified in Japanese patients with ataxia-telangiectasia. (PubMed id 22006793)1 Nakamura K....Gatti R.A. (Hum. Mutat. 2012)
    420. Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. (PubMed id 23154512)1 Beggs A.D....Tomlinson I.P. (Oncotarget 2012)
    421. Prognostic significance of ATM and cyclin B1 in pancreatic neuroendocrine tumor. (PubMed id 22707287)1 Shin J.U....Rhee J.C. (Tumour Biol. 2012)
    422. DNA damage-induced activation of ATM promotes I^-TRCP-mediated Mdm2 ubiquitination and destruction. (PubMed id 22976441)1 Wang Z....Wei W. (Oncotarget 2012)
    423. A new minimal deleted region at 11q22.3 reveals the importance of interpretation of diminished FISH signals and the choice of probe for ATM deletion screening in chronic lymphocytic leukemia. (PubMed id 21955805)1 Gardiner A....Strefford J. (Leuk. Res. 2012)
    424. Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase. (PubMed id 22730303)1 KAPcher S....Dahm-Daphi J. (Nucleic Acids Res. 2012)
    425. Metastasis of neuroendocrine tumors are characterized by increased cell proliferation and reduced expression of the ATM gene. (PubMed id 22485171)1 Lee J....Park Y.S. (PLoS ONE 2012)
    426. Association between ATM 5557G&gt;A polymorphism and breast cancer risk: a meta-analysis. (PubMed id 21603857)1 Mao C....Tang J.L. (Mol. Biol. Rep. 2012)
    427. Variation in telangiectasia predisposing genes isA associated with overall radiation toxicity. (PubMed id 22677372)1 Tanteles G.A....Symonds R.P. (Int. J. Radiat. Oncol. Biol. Phys. 2012)
    428. ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability. (PubMed id 22453082)1 Shin M.H....Kai M. (Cell Cycle 2012)
    429. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. (PubMed id 22660439)1 Sullivan K.D....Espinosa J.M. (Nat. Chem. Biol. 2012)
    430. ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression. (PubMed id 21993670)1 Guarini A....FoA R. (Haematologica 2012)
    431. No evidence for DNA methylation of the ATM promoter CpG island in chronic lymphocytic leukemia. (PubMed id 22204453)1 Mikeska T....Dobrovic A. (amp 2012)
    432. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. (PubMed id 22869596)1 Yamamoto K....Zha S. (J. Cell Biol. 2012)
    433. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. (PubMed id 22854598)1 Ando K....Sidi S. (Mol. Cell 2012)
    434. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. (PubMed id 22361354)1 Khoronenkova S.V....Dianov G.L. (Mol. Cell 2012)
    435. Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study. (PubMed id 22369572)1 Lozanski G....Byrd J.C. (amp 2012)
    436. An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control. (PubMed id 23176708)1 Cheung H.C....Ribes-Zamora A. (BMC Genomics 2012)
    437. Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk. (PubMed id 22374981)1 Brennan K....Flanagan J.M. (Cancer Res. 2012)
    438. Quantitative proteomics reveal ATM kinase-dependent exchange in DNA damage response complexes. (PubMed id 22909323)1 Choi S....Bakkenist C.J. (J. Proteome Res. 2012)
    439. ATM mediates interdependent activation of p53 and ERK through formation of a ternary complex with p-p53 and p-ERK in response to DNA damage. (PubMed id 22576881)1 Heo J.I....Lee J.Y. (Mol. Biol. Rep. 2012)
    440. Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin. (PubMed id 23185347)1 Zakikhani M....Pollak M.N. (PLoS ONE 2012)
    441. Association between ATM polymorphisms and cancer risk: a meta-analysis. (PubMed id 22203481)1 Shen L....Zhou B.S. (Mol. Biol. Rep. 2012)
    442. ATM-mediated DNA damage signals mediate immune escape through integrin-I+vI^3-dependent mechanisms. (PubMed id 22094875)1 Jinushi M....Takaoka A. (Cancer Res. 2012)
    443. Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations. (PubMed id 22071889)1 Jacquemin V....Stern M.H. (Eur. J. Hum. Genet. 2012)
    444. ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele. (PubMed id 21933854)1 Skowronska A....Stankovic T. (Haematologica 2012)
    445. Increases in mitochondrial DNA content and 4977-bp deletion upon ATM/Chk2 checkpoint activation in HeLa cells. (PubMed id 22808196)1 Niu R....Ling F. (PLoS ONE 2012)
    446. Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients. (PubMed id 21850541)1 Salimi M....Majidzadeh K. (Med. Oncol. 2012)
    447. The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program. (PubMed id 22751958)1 Florez J.C....Pollin T.I. (Diabetes Care 2012)
    448. Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1. (PubMed id 22451389)1 Li Y....Ubukata M. (Biosci. Biotechnol. Biochem. 2012)
    449. The role of ATM and 53BP1 as predictive markers in cervical cancer. (PubMed id 22323184)1 Roossink F....van Vugt M.A. (Int. J. Cancer 2012)
    450. Phospho-I9Np63I+/SREBF1 protein interactions: bridging cell metabolism and cisplatin chemoresistance. (PubMed id 22951905)1 Huang Y....Ratovitski E.A. (Cell Cycle 2012)
    451. The association between ATM IVS 22-77 T&gt;C and cancer risk: a meta-analysis. (PubMed id 22276117)1 Zhao L....Lu A. (PLoS ONE 2012)
    452. Activation of the ATM-Snail pathway promotes breast cancer metastasis. (PubMed id 22923499)1 Sun M....Xu B. (J Mol Cell Biol 2012)
    453. Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma. (PubMed id 22438227)1 Xu L....Ward L.S. (J. Clin. Endocrinol. Metab. 2012)
    454. The role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotection. (PubMed id 23239948)1 Marinoglou K. (Yale J Biol Med 2012)
    455. ATM suppresses SATB1-induced malignant progression in breast epithelial cells. (PubMed id 23251624)1 Ordinario E....Kohwi-Shigematsu T. (PLoS ONE 2012)
    456. Genetic polymorphisms and cervical cancer development: ATM G5557A and p53bp1 C1236G. (PubMed id 22200742)1 Oliveira S....Medeiros R. (Oncol. Rep. 2012)
    457. Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy. (PubMed id 22537351)1 Raabe A....Dikomey E. (Radiat Oncol 2012)
    458. ATM-mediated phosphorylation activates the tumor-suppressive function of B56I^-PP2A. (PubMed id 21460856)1 Shouse G.P....Liu X. (Oncogene 2011)
    459. ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability. (PubMed id 21460853)1 Goetz E.M....Boothman D.A. (Oncogene 2011)
    460. Alterations of ATM and CADM1 in chromosomal 11q22.3-23.2 region are associated with the development of invasive cervical carcinoma. (PubMed id 21643982)1 Mazumder Indra D....Panda C.K. (Hum. Genet. 2011)
    461. ATM-dependent cellular response to DNA double strand breaks plays a pivotal role in the maintenance of the integrity of the genome. (PubMed id 21224259)1 Suzuki K....Yamashita S. (Radiat Prot Dosimetry 2011)
    462. A putative &quot;hepitype&quot; in the ATM gene associated with chronic lymphocytic leukemia risk. (PubMed id 21910157)1 MartA-n-Guerrero I....GarcA-a-Orad A. (amp 2011)
    463. EDD inhibits ATM-mediated phosphorylation of p53. (PubMed id 21383020)1 Ling S. and Lin W.C. (J. Biol. Chem. 2011)
    464. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    465. Human T-lymphotropic virus type 1 p30 interacts with REGgamma and modulates ATM (ataxia telangiectasia mutated) to promote cell survival. (PubMed id 21216954)1 Anupam R....Lairmore M.D. (J. Biol. Chem. 2011)
    466. Mode of ATM-dependent suppression of chromosome translocation. (PubMed id 22093823)1 Yamauchi M....Yamashita S. (Biochem. Biophys. Res. Commun. 2011)
    467. Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional. (PubMed id 21532626)1 Lossaint G....DuliA8 V. (Oncogene 2011)
    468. The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells. (PubMed id 21874023)1 Norman J.M....Collins K.L. (Nat. Immunol. 2011)
    469. Transforming growth factor-I^ regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. (PubMed id 21102523)1 Wang Y....Wang S.E. (Oncogene 2011)
    470. Functional polymorphism rs189037 in the promoter region of ATM gene is associated with angiographically characterized coronary stenosis. (PubMed id 21937043)1 Li S....Mo X. (Atherosclerosis 2011)
    471. Autophosphorylation and ATM activation: additional sites add to the complexity. (PubMed id 21149446)1 Kozlov S.V....Lavin M.F. (J. Biol. Chem. 2011)
    472. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    473. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. (PubMed id 21186350)1  ....Pearson E.R. (Nat. Genet. 2011)
    474. Lower ataxia telangiectasia mutated (ATM) mRNA expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients. (PubMed id 21127011)1 Lee K.W....Lin C.S. (Ann. Oncol. 2011)
    475. ATM mediated phosphorylation of CHD4 contributes to genome maintenance. (PubMed id 21219611)1 Urquhart A.J....Khanna K.K. (Genome Integr 2011)
    476. A positive role for c-Abl in Atm and Atr activation in DNA damage response. (PubMed id 20798688)1 Wang X....Li B. (Cell Death Differ. 2011)
    477. Lack of association between ATM C.1066-6T &gt; G mutation and breast cancer risk: a meta-analysis of 8,831 cases and 4,957 controls. (PubMed id 20544271)1 Ding H....Chen Q. (Breast Cancer Res. Treat. 2011)
    478. Genetic polymorphisms in ATM, ERCC1, APE1 and iASPP genes and lung cancer risk in a population of southeast China. (PubMed id 20354815)1 Deng Q....Ma S. (Med. Oncol. 2011)
    479. Identification of SNF2h, a chromatin-remodeling factor, as a novel binding protein of Vpr of human immunodeficiency virus type 1. (PubMed id 21519849)1 Taneichi D....Ishizaka Y. (J Neuroimmune Pharmacol 2011)
    480. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    481. Importance of ATM gene as a susceptible trait: predisposition role of D1853N polymorphism in breast cancer. (PubMed id 20396981)1 Mehdipour P....Atri M. (Med. Oncol. 2011)
    482. Analysis of D1853N ATM polymorphism in radiosensitive patients with cervical carcinoma. (PubMed id 22250480)1 BerA!nek M....Petera J. (Acta Medica (Hradec Kralove) 2011)
    483. Protein phosphatase 5 is necessary for ATR-mediated DNA repair. (PubMed id 21144835)2 Kang Y....You H.J. (Biochem. Biophys. Res. Commun. 2011)
    484. Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours. (PubMed id 21792198)1 Reiman A....Taylor A.M. (Br. J. Cancer 2011)
    485. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. (PubMed id 21157431)1 Cosentino C....Costanzo V. (EMBO J. 2011)
    486. Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts. (PubMed id 21824286)1 Mahalingam D....Wang X. (FEBS J. 2011)
    487. A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. (PubMed id 20644561)1 Ho-Pun-Cheung A....Lopez-Crapez E. (Pharmacogenomics J. 2011)
    488. Ethanol metabolism activates cell cycle checkpoint kinase, Chk2. (PubMed id 21924579)1 Clemens D.L....Nuss R.F. (Alcohol 2011)
    489. Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response. (PubMed id 21245467)1 Hadian K. and Krappmann D. (Sci Signal 2011)
    490. New mutations in the ATM gene and clinical data of 25 AT patients. (PubMed id 21965147)1 Demuth I....Varon R. (Neurogenetics 2011)
    491. Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing. (PubMed id 21858080)1 Pastor T. and Pagani F. (PLoS ONE 2011)
    492. Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy. (PubMed id 20729006)1 Yang M....Lin D. (Int. J. Radiat. Oncol. Biol. Phys. 2011)
    493. ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance. (PubMed id 21518729)1 Millour J....Lam E.W. (Mol. Cancer Ther. 2011)
    494. Association between Ataxia Telangiectasia Mutated gene polymorphisms and childhood leukemia in Taiwan. (PubMed id 22229509)1 Wang C.H....Bau D.T. (Chin J Physiol 2011)
    495. ATM protects against oxidative stress induced by oxidized low-density lipoprotein. (PubMed id 21669554)1 Semlitsch M....Malle E. (DNA Repair (Amst.) 2011)
    496. miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase. (PubMed id 21980462)1 Song L....Li J. (PLoS ONE 2011)
    497. Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase. (PubMed id 21908846)1 Nam E.A....Cortez D. (J. Biol. Chem. 2011)
    498. The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling. (PubMed id 20933509)1 Valdez B.C....Andersson B.S. (Biochem. Pharmacol. 2011)
    499. Dissection of cell context-dependent interactions between HBx and p53 family members in regulation of apoptosis: a role for HBV-induced HCC. (PubMed id 22030623)1 Knoll S....PA1tzer B.M. (Cell Cycle 2011)
    500. Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair. (PubMed id 21596788)1 Woodbine L....Jeggo P.A. (Nucleic Acids Res. 2011)
    501. Chromosomal breaks during mitotic catastrophe trigger I^H2AX-ATM-p53-mediated apoptosis. (PubMed id 21878502)1 Imreh G....Zhivotovsky B. (J. Cell. Sci. 2011)
    502. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1). (PubMed id 21502314)1 Lindsey-Boltz L.A. and Sancar A. (J. Biol. Chem. 2011)
    503. TRAIL and guardian angel of genome integrity: ATM boards TRAIL blazer. (PubMed id 21706325)1 Farooqi A.A....Bhatti S. (J. Cancer Res. Clin. Oncol. 2011)
    504. Role of DeltaNp63gamma in epithelial to mesenchymal transition. (PubMed id 21127042)1 Lindsay J....McCance D.J. (J. Biol. Chem. 2011)
    505. Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. (PubMed id 21204616)1 Wang S.C....Chiang C.S. (Int. J. Radiat. Biol. 2011)
    506. Cutaneous squamous cell carcinoma (SCC) and the DNA damage response: pATM expression patterns in pre-malignant and malignant keratinocyte skin lesions. (PubMed id 21747934)1 Ismail F....Storey A. (PLoS ONE 2011)
    507. The phenotypic radiation resistance of CD44+/CD24(-or low) breast cancer cells is mediated through the enhanced activation of ATM signaling. (PubMed id 21935375)1 Yin H. and Glass J. (PLoS ONE 2011)
    508. [Association between single nucleotide polymorphism locus rs189037 in the promoter of ATM gene and nasopharyngeal carcinoma susceptibility in Cantonese]. (PubMed id 22126766)1 Wang H.M....Zheng X.K. (Nan Fang Yi Ke Da Xue Xue Bao 2011)
    509. Does metformin work for everyone? A genome-wide association study for metformin response. (PubMed id 21845381)1 Florez J.C. (Curr. Diab. Rep. 2011)
    510. ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. (PubMed id 21263216)1 Khalil A....Valerie K. (Cell Cycle 2011)
    511. A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway. (PubMed id 21298066)1 Wood L.M....Desai S.D. (PLoS ONE 2011)
    512. Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia. (PubMed id 21593342)1 Li J....Herrup K. (J. Neurosci. 2011)
    513. IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. (PubMed id 21573174)1 Duan X.... Choubey D. (PLoS ONE 2011)
    514. Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. (PubMed id 22159035)1 Coufal N.G....Gage F.H. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    515. Integrated analysis of ATM mediated gene and protein expression impacting cellular metabolism. (PubMed id 21322649)1 Cheema A.K....Dritschilo A. (J. Proteome Res. 2011)
    516. The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA. (PubMed id 21487018)1 Kemp M.G....Sancar A. (J. Biol. Chem. 2011)
    517. Characterisation of ATM mutations in Slavic Ataxia telangiectasia patients. (PubMed id 21833744)1 Soukupova J....Seemanova E. (Neuromolecular Med. 2011)
    518. DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas. (PubMed id 21504893)1 Gao Y....Berndt S.I. (Carcinogenesis 2011)
    519. Damage control: how HIV survives the editor APOBEC3G. (PubMed id 21934670)1 Croxford J.L. and Gasser S. (Nat. Immunol. 2011)
    520. Genetic variants of NPAT-ATM and AURKA are associated with an early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy. (PubMed id 21050672)1 Ishikawa A....Imai T. (Int. J. Radiat. Oncol. Biol. Phys. 2011)
    521. ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair. (PubMed id 21637298)1 Segal-Raz H....Shiloh Y. (EMBO Rep. 2011)
    522. An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. (PubMed id 21937706)1 Ramachandran S....Tamura T. (RNA 2011)
    523. Association between polymorphisms of the ataxia telangiectasia mutated gene and breast cancer risk: evidence from the current studies. (PubMed id 20665102)1 Lu P.H....Chen M.B. (Breast Cancer Res. Treat. 2011)
    524. Nuclear epidermal growth factor receptor modulates cellular radio-sensitivity by regulation of chromatin access. (PubMed id 21704408)1 Dittmann K....Rodemann H.P. (Radiother Oncol 2011)
    525. Germline ATM mutational analysis in BRCA1/BRCA2 negative hereditary breast cancer families by MALDI-TOF mass spectrometry. (PubMed id 21445571)1 GraA+a B....Brunet J. (Breast Cancer Res. Treat. 2011)
    526. Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage. (PubMed id 21361779)1 Al Rashid S.T....Bristow R.G. (Radiat. Res. 2011)
    527. A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. (PubMed id 21606198)1 Yang Y....Kelliher M.A. (Mol. Cell. Biol. 2011)
    528. ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. (PubMed id 21209379)1 Mazan-Mamczarz K....Gartenhaus R.B. (Blood 2011)
    529. Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest. (PubMed id 21791604)1 Brunton H....Shibata A. (Mol. Cell. Biol. 2011)
    530. ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. (PubMed id 21757780)1 Gatei M....Lavin M.F. (J. Biol. Chem. 2011)
    531. Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways. (PubMed id 21778326)1 Keimling M....WiesmA1ller L. (FASEB J. 2011)
    532. Expression of cyclin D2, P53, Rb and ATM cell cycle genes in brain tumors. (PubMed id 20077038)1 Kheirollahi M....Mehdipour P. (Med. Oncol. 2011)
    533. Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-I_B regulated ATM expression. (PubMed id 22096476)1 Ma X....Cao Y. (PLoS ONE 2011)
    534. Monoubiquitination of H2AX protein regulates DNA damage response signaling. (PubMed id 21676867)1 Pan M.R....Lin S.Y. (J. Biol. Chem. 2011)
    535. Rare variants in the ATM gene and risk of breast cancer. (PubMed id 21787400)1 Goldgar D.E....Chenevix-Trench G. (Breast Cancer Res. 2011)
    536. Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity. (PubMed id 21849032)1 Wang J....Zhou G. (Radiat Oncol 2011)
    537. Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype. (PubMed id 21665257)1 Micol R....Stoppa-Lyonnet D. (J. Allergy Clin. Immunol. 2011)
    538. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. (PubMed id 21362549)1 Moyal L....Shiloh Y. (Mol. Cell 2011)
    539. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    540. Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript. (PubMed id 20103595)1 Yang R....Carrier F. (J. Biol. Chem. 2010)
    541. DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation. (PubMed id 20663147)1 Craig A.L....Vojtesek B. (Mol. Cancer 2010)
    542. Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. (PubMed id 20019063)1 Bolderson E....Khanna K.K. (Nucleic Acids Res. 2010)
    543. ATM is down-regulated by N-Myc-regulated microRNA-421. (PubMed id 20080624)1 Hu H....Gatti R.A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    544. The intronic splicing code: multiple factors involved in ATM pseudoexon definition. (PubMed id 20094034)1 Dhir A....Baralle F.E. (EMBO J. 2010)
    545. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-I_B activation. (PubMed id 20932475)1 Hinz M....Scheidereit C. (Mol. Cell 2010)
    546. Activator-Mediator binding regulates Mediator-cofactor interactions. (PubMed id 20534441)1 Ebmeier C.C. and Taatjes D.J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    547. Per3, a circadian gene, is required for Chk2 activation in human cells. (PubMed id 21070773)1 Im J.S....Lee J.K. (FEBS Lett. 2010)
    548. ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response. (PubMed id 20164679)1 Jang E.R....Lee J.S. (amp 2010)
    549. Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants. (PubMed id 20368801)1 Adams B.R....Valerie K. (PLoS ONE 2010)
    550. Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM. (PubMed id 20372057)1 Bower J.J....Kaufmann W.K. (Cell Cycle 2010)
    551. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. (PubMed id 21034966)1 Smith J....Gillespie D.A. (Adv. Cancer Res. 2010)
    552. Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J. (PubMed id 20869334)1 Ng W.L....Wang Y. (DNA Repair (Amst.) 2010)
    553. A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage. (PubMed id 20599567)1 Carlessi L....Delia D. (Biochim. Biophys. Acta 2010)
    554. A functional single nucleotide polymorphism in promoter of ATM is associated with longevity. (PubMed id 20816691)1 Chen T....Mo X. (Mech. Ageing Dev. 2010)
    555. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    556. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. (PubMed id 20048340)1 Yoshida K....Fujita M. (J. Cell. Sci. 2010)
    557. Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence. (PubMed id 20639198)1 Zhan H....Nagai R. (J. Biol. Chem. 2010)
    558. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. (PubMed id 20550933)1 Shanbhag N.M....Greenberg R.A. (Cell 2010)
    559. ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. (PubMed id 20124459)1 Williamson C.T....Lees-Miller S.P. (Mol. Cancer Ther. 2010)
    560. Mitotic DNA damage response: Polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway. (PubMed id 20581453)1 Lee H.J....Jang Y.J. (Cell Cycle 2010)
    561. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1I+. (PubMed id 21095582)1 Cam H....Houghton P.J. (Mol. Cell 2010)
    562. ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress. (PubMed id 20713054)1 Wang S....Zhang L. (FEBS Lett. 2010)
    563. Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease. (PubMed id 20676049)1 Ousset M....Muller C. (Cell Cycle 2010)
    564. ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating. (PubMed id 20448412)1 Takahashi A....Ohnishi T. (J. Radiat. Res. 2010)
    565. BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery. (PubMed id 20668194)1 Facchino S....Bernier G. (J. Neurosci. 2010)
    566. ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. (PubMed id 20932476)1 Wu Z.H....Tergaonkar V. (Mol. Cell 2010)
    567. Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control. (PubMed id 19996108)1 Yang X....Hrushesky W.J. (J. Biol. Chem. 2010)
    568. Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange. (PubMed id 20516478)1 White J.S....Bakkenist C.J. (Sci Signal 2010)
    569. ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining. (PubMed id 20647759)1 Rahal E.A....Dixon K. (Cell Cycle 2010)
    570. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. (PubMed id 20160076)1 Alexander A.... Walker C.L. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    571. Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. (PubMed id 20838624)1 Corbo V....Scarpa A. (PLoS ONE 2010)
    572. Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells. (PubMed id 20709753)1 Qi Y....Cheng W.H. (J. Biol. Chem. 2010)
    573. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. (PubMed id 21139141)1 Bensimon A....Shiloh Y. (Sci Signal 2010)
    574. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. (PubMed id 21048951)1 Sun J....Tashiro S. (PLoS ONE 2010)
    575. Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. (PubMed id 21156285)1 Squatrito M....Holland E.C. (Cancer Cell 2010)
    576. Phosphorylation of p300 by ATM controls the stability of NBS1. (PubMed id 20471956)1 Jang E.R....Lee J.S. (Biochem. Biophys. Res. Commun. 2010)
    577. Genomic instability--an evolving hallmark of cancer. (PubMed id 20177397)1 Negrini S....Halazonetis T.D. (Nat. Rev. Mol. Cell Biol. 2010)
    578. Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling. (PubMed id 19903823)1 Orba Y....Sawa H. (J. Biol. Chem. 2010)
    579. Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway. (PubMed id 20065354)1 Rosato R.R....Grant S. (J. Biol. Chem. 2010)
    580. Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C. (PubMed id 20514472)1 Moon D.O....Kim G.Y. (Oncol. Rep. 2010)
    581. AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. (PubMed id 20864035)1 Sherman M.H....Teitell M.A. (Mol. Cell 2010)
    582. ATM activation by oxidative stress. (PubMed id 20966255)1 Guo Z....Paull T.T. (Science 2010)
    583. DNA damage signaling is activated during cancer progression in human colorectal carcinoma. (PubMed id 20023412)1 Oka K....Hamano K. (amp 2010)
    584. Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. (PubMed id 19444312)1 Tomimatsu N....Burma S. (EMBO Rep. 2009)
    585. A unique lethal blastoid transformation of B-cell chronic lymphocytic leukemia carrying ATM/11q deletion and trisomy 12. (PubMed id 19269030)1 Lu Y. and Huang Q. (Leuk. Res. 2009)
    586. Silencing the Metallothionein-2A gene inhibits cell cycle progression from G1- to S-phase involving ATM and cdc25A signaling in breast cancer cells. (PubMed id 19062161)1 Lim D....Bay B.H. (Cancer Lett. 2009)
    587. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. (PubMed id 20026654)1 So S....Chen D.J. (J. Cell Biol. 2009)
    588. Vpr and its interactions with cellular proteins. (PubMed id 20012529)1 Planelles V. and Benichou S. (Curr. Top. Microbiol. Immunol. 2009)
    589. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)
    590. DNA double strand break repair enzymes function at multiple steps in retroviral infection. (PubMed id 20003485)1 Sakurai Y....Matsuoka M. (Retrovirology 2009)
    591. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. (PubMed id 19451263)1 Shao L....Weyand C.M. (J. Exp. Med. 2009)
    592. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. (PubMed id 19783983)1 Sun Y....Price B.D. (Nat. Cell Biol. 2009)
    593. T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. (PubMed id 20064447)1 Borbulevych O.Y....Baker B.M. (Immunity 2009)
    594. Structure-function relationship of Vpr: biological implications. (PubMed id 19275588)1 Morellet N....Bouaziz S. (Curr. HIV Res. 2009)
    595. Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation. (PubMed id 19798429)1 Moody C.A. and Laimins L.A. (PLoS Pathog. 2009)
    596. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    597. Vpr-induced DNA double-strand breaks: molecular mechanism and biological relevance. (PubMed id 19275579)1 Nakai-Murakami C....Ishizaka Y. (Curr. HIV Res. 2009)
    598. Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. (PubMed id 19781682)1 Tavtigian S.V....Chenevix-Trench G. (Am. J. Hum. Genet. 2009)
    599. Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway. (PubMed id 19527713)1 Nakayama Y....Yamaguchi N. (Exp. Cell Res. 2009)
    600. Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1. (PubMed id 19338747)1 Kobayashi J....Komatsu K. (Biochem. Biophys. Res. Commun. 2009)
    601. Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. (PubMed id 19851285)1 Das B.B....Pommier Y. (EMBO J. 2009)
    602. The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope. (PubMed id 19023333)1 Perfettini J.L....Kroemer G. (Cell Death Differ. 2009)
    603. The CXXC finger 5 protein is required for DNA damage-induced p53 activation. (PubMed id 19557330)1 Zhang M.... Shu H.-B. (Sci. China, Ser. C, Life Sci. 2009)
    604. Breaks invisible to the DNA damage response machinery accumulate in ATM-deficient cells. (PubMed id 19455703)1 MartA-n M....GenescA A. (amp 2009)
    605. ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. (PubMed id 19079347)1 Grosjean-Raillard J....Kroemer G. (Oncogene 2009)
    606. ATM activation and signaling under hypoxic conditions. (PubMed id 18981219)1 Bencokova Z....Hammond E.M. (Mol. Cell. Biol. 2009)
    607. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. (PubMed id 19285939)1 Shiotani B. and Zou L. (Mol. Cell 2009)
    608. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    609. Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. (PubMed id 19881958)1 Zhu H....Ding J. (Neoplasia 2009)
    610. ATM blocks tunicamycin-induced endoplasmic reticulum stress. (PubMed id 19302790)1 He L....Kim B.Y. (FEBS Lett. 2009)
    611. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (Blood 2009)
    612. Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation. (PubMed id 19583974)1 Xue L....Fan S. (Mutat. Res. 2009)
    613. ATM regulates a RASSF1A-dependent DNA damage response. (PubMed id 19962312)1 Hamilton G....O'Neill E. (Curr. Biol. 2009)
    614. Do checkpoint kinases contribute to HIV-1-mediated apoptosis? (PubMed id 19164952)1 Vakifahmetoglu H. and Zhivotovsky B. (Cell Cycle 2009)
    615. Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. (PubMed id 19557000)1 Sordet O....Pommier Y. (EMBO Rep. 2009)
    616. Mechanism of beta-carotene-induced apoptosis of gastric cancer cells: involvement of ataxia-telangiectasia-mutated. (PubMed id 19723050)1 Jang S.H....Kim H. (Ann. N. Y. Acad. Sci. 2009)
    617. SOCS1 links cytokine signaling to p53 and senescence. (PubMed id 20005840)1 Calabrese V....Ferbeyre G. (Mol. Cell 2009)
    618. SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. (PubMed id 18848520)1 Akhter S. and Legerski R.J. (Biochem. Biophys. Res. Commun. 2008)
    619. ATM gene mutations result in both recessive and dominant expression phenotypes of genes and microRNAs. (PubMed id 18674748)1 Smirnov D.A. and Cheung V.G. (Am. J. Hum. Genet. 2008)
    620. DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. (PubMed id 18644470)1 Yu Y....Lees-Miller S.P. (DNA Repair (Amst.) 2008)
    621. Regulation of TIP60 by ATF2 modulates ATM activation. (PubMed id 18397884)1 Bhoumik A....Ronai Z.A. (J. Biol. Chem. 2008)
    622. Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress. (PubMed id 18583959)1 Wu Z.H. and Miyamoto S. (EMBO J. 2008)
    623. hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress. (PubMed id 18332866)1 Gehen S.C....O'Reilly M.A. (Oncogene 2008)
    624. Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response. (PubMed id 18434398)1 Chandhasin C....Marriott S.J. (J. Virol. 2008)
    625. A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. (PubMed id 18250156)1 Tang X.... Xu B. (Mol. Cell. Biol. 2008)
    626. Large genomic mutations within the ATM gene detected by MLPA, including a duplication of 41 kb from exon 4 to 20. (PubMed id 17910737)1 Cavalieri S....Brusco A. (Ann. Hum. Genet. 2008)
    627. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. (PubMed id 18596698)1 Jazayeri A....Costanzo V. (EMBO J. 2008)
    628. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    629. Potency and property of DNA conformational damage determine ATM activation: two new DNA topological probes. (PubMed id 18788070)1 Zhang Z....Qian X. (Cell Biochem. Funct. 2008)
    630. Three-hit hypothesis in astrocytoma: tracing the polymorphism D1853N in ATM gene through a pedigree of the proband affected with primary brain tumor. (PubMed id 18465141)1 Mehdipour P....Mehr Azin M. (J. Cancer Res. Clin. Oncol. 2008)
    631. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. (PubMed id 18769144)1 Huang Y....Sidransky D. (Cell Cycle 2008)
    632. HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier? (PubMed id 18577246)1 Nunnari G....Daniel R. (amp 2008)
    633. WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. (PubMed id 18596239)1 Cheng W.H....Bohr V.A. (Mol. Biol. Cell 2008)
    634. Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children's Oncology Group. (PubMed id 18261794)1 Gumy-Pause F....Sappino A.P. (Leuk. Res. 2008)
    635. ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage. (PubMed id 19015526)1 Chang L....Yen Y. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    636. DNA-PKcs and ATM influence generation of ionizing radiation-induced bystander signals. (PubMed id 18679419)1 Hagelstrom R.T....Bailey S.M. (Oncogene 2008)
    637. Interplay between ATM and ATR in the regulation of common fragile site stability. (PubMed id 17934520)1 Ozeri-Galai E....Kerem B. (Oncogene 2008)
    638. Identification of p32 as a novel substrate for ATM in heart. (PubMed id 18070599)1 Kato H....Hori M. (Biochem. Biophys. Res. Commun. 2008)
    639. DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells. (PubMed id 18172300)1 Arlander S.J....Paules R.S. (Cancer Res. 2008)
    640. Identification and characterization of FUS/TLS as a new target of ATM. (PubMed id 18620545)1 Gardiner M....Rouse J. (Biochem. J. 2008)
    641. Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity. (PubMed id 18418045)1 White J.S....Bakkenist C.J. (Cell Cycle 2008)
    642. HIV-1 Vpr: mechanisms of G2 arrest and apoptosis. (PubMed id 18514189)1 Andersen J.L....Planelles V. (Exp. Mol. Pathol. 2008)
    643. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. (PubMed id 18931676)1 Ishiai M....Takata M. (amp 2008)
    644. Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes. (PubMed id 19050264)1 Dabrowska A....Aldovini A. (J. Immunol. 2008)
    645. A role for E1B-AP5 in ATR signaling pathways during adenovirus infection. (PubMed id 18480432)1 Blackford A.N....Turnell A.S. (J. Virol. 2008)
    646. ATM acts downstream of ATR in the DNA damage response signaling of bystander cells. (PubMed id 18757420)1 Burdak-Rothkamm S....Prise K.M. (Cancer Res. 2008)
    647. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. (PubMed id 18593932)1 Stohr B.A. and Blackburn E.H. (Cancer Res. 2008)
    648. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. (PubMed id 18657500)1 Goodarzi A.A....Jeggo P.A. (Mol. Cell 2008)
    649. ATM in oral carcinogenesis: association with clinicopathological features. (PubMed id 18288488)1 He Y....Li B. (J. Cancer Res. Clin. Oncol. 2008)
    650. Ionizing radiation can induce GSK-3beta phosphorylation and NF-kappaB transcriptional transactivation in ATM-deficient fibroblasts. (PubMed id 18243662)1 Kwon O....Kim B.Y. (Cell. Signal. 2008)
    651. Functional interaction between FOXO3a and ATM regulates DNA damage response. (PubMed id 18344987)1 Tsai W.B....Hu M.C. (Nat. Cell Biol. 2008)
    652. Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase. (PubMed id 18480045)1 Jin J....Harper J.W. (J. Biol. Chem. 2008)
    653. Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories? (PubMed id 18557994)1 Byrnes G.B....Hopper J.L. (Breast Cancer Res. 2008)
    654. Comprehensive analysis of DNA repair gene variants and risk of meningioma. (PubMed id 18270339)1 Bethke L....Houlston R. (J. Natl. Cancer Inst. 2008)
    655. Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study. (PubMed id 18456456)1 Sasaki M....Nakanuma Y. (J. Autoimmun. 2008)
    656. ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance. (PubMed id 18829552)1 Ewald B....Plunkett W. (Cancer Res. 2008)
    657. Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. (PubMed id 18536714)1 Winter M.... Hofmann T.G. (Nat. Cell Biol. 2008)
    658. Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM. (PubMed id 18343821)1 Kim K.J.... Kang B.S. (J. Biol. Chem. 2008)
    659. Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation. (PubMed id 18468965)1 Demuth I.... Concannon P. (DNA Repair 2008)
    660. Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. (PubMed id 18283122)2 Sivasubramaniam S.... Lee E.Y. (Genes Dev. 2008)
    661. ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain. (PubMed id 17706468)1 Gorodetsky E....Brooks P.J. (DNA Repair (Amst.) 2007)
    662. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. (PubMed id 17609267)1 Iwahori S....Tsurumi T. (J. Virol. 2007)
    663. Lead contamination results in late and slowly repairable DNA double-strand breaks and impacts upon the ATM-dependent signaling pathways. (PubMed id 17855027)1 Gastaldo J....Foray N. (Toxicol. Lett. 2007)
    664. Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer. (PubMed id 17166884)1 PylkAos K....Winqvist R. (Carcinogenesis 2007)
    665. Correction of prototypic ATM splicing mutations and aberrant ATM function with antisense morpholino oligonucleotides. (PubMed id 17389389)1 Du L....Gatti R.A. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    666. Tel2 regulates the stability of PI3K-related protein kinases. (PubMed id 18160036)1 Takai H....de Lange T. (Cell 2007)
    667. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. (PubMed id 18006705)1 Kolas N.K.... Durocher D. (Science 2007)
    668. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    669. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (Science 2007)
    670. Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells. (PubMed id 17606465)1 Ambrose M....Gatti R.A. (Hum. Mol. Genet. 2007)
    671. [Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]. (PubMed id 17626748)1 Zhuang L....Xiong H.H. (Ai Zheng 2007)
    672. ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes. (PubMed id 17008050)1 Guo C....Larner J.M. (Cell. Signal. 2007)
    673. Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B. (PubMed id 17242184)1 Geng L....Legerski R.J. (Mol. Cell. Biol. 2007)
    674. Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. (PubMed id 17189255)1 Chen B.P....Chen D.J. (J. Biol. Chem. 2007)
    675. Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression. (PubMed id 17942393)1 Li X.... Ann D.K. (J. Biol. Chem. 2007)
    676. Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. (PubMed id 17428792)1 Haince J.F....Poirier G.G. (J. Biol. Chem. 2007)
    677. Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes. (PubMed id 17227291)1 Tanaka T....Darzynkiewicz Z. (Cell Prolif. 2007)
    678. Reoxygenation following hypoxia activates DNA-damage checkpoint signaling pathways that suppress cell-cycle progression in cultured human lymphocytes. (PubMed id 17544403)1 Kim B.M....Chung H.W. (FEBS Lett. 2007)
    679. The ATM/ATR signaling effector Chk2 is targeted by Epstein-Barr virus nuclear antigen 3C to release the G2/M cell cycle block. (PubMed id 17409144)1 Choudhuri T....Robertson E.S. (J. Virol. 2007)
    680. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. (PubMed id 17478428)1 Mu J.J....Qin J. (J. Biol. Chem. 2007)
    681. Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. (PubMed id 17611684)1 Iguchi T....Kizaki M. (Int. J. Oncol. 2007)
    682. Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. (PubMed id 17384681)1 McConnell J.L.... Wadzinski B.E. (Oncogene 2007)
    683. HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination. (PubMed id 16983346)1 Nakai-Murakami C....Ishizaka Y. (Oncogene 2007)
    684. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. (PubMed id 17274640)1 Flores-Delgado G....Berndt N. (J. Proteome Res. 2007)
    685. Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines. (PubMed id 17019709)1 Jiang Y....Xu X.C. (Int. J. Cancer 2007)
    686. Characterization of genetic changes in MCL by interphase FISH on tissue sections. (PubMed id 17613764)1 Sander B....Kimby E. (amp 2007)
    687. RNA structure is a key regulatory element in pathological ATM and CFTR pseudoexon inclusion events. (PubMed id 17580311)1 Buratti E....Baralle F.E. (Nucleic Acids Res. 2007)
    688. ATM prevents unattended DNA double strand breaks on site and in generations to come. (PubMed id 18087222)1 Yin B....Bassing C.H. (amp 2007)
    689. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. (PubMed id 17426037)1 Fernandes N.D....Price B.D. (J. Biol. Chem. 2007)
    690. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. (PubMed id 17244605)1 Shi Y....Tibbetts R.S. (J. Biol. Chem. 2007)
    691. Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase. (PubMed id 18171990)1 Olofsson B.A.... Azizkhan-Clifford J. (Mol. Cancer Res. 2007)
    692. Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. (PubMed id 17786248)1 Eaton J.S....Shadel G.S. (J. Clin. Invest. 2007)
    693. Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions. (PubMed id 17384674)1 Sakamoto S....Komatsu K. (Oncogene 2007)
    694. Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A. (PubMed id 17121863)1 Jang Y.J....Ko S.Y. (J. Biol. Chem. 2007)
    695. ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke. (PubMed id 17594478)1 Tanaka T....Albino A.P. (BMC Cell Biol. 2007)
    696. Ataxia-telangiectasia: mild neurological presentation despite null ATM mutation and severe cellular phenotype. (PubMed id 17632790)1 Alterman N....Shiloh Y. (Am. J. Med. Genet. A 2007)
    697. Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. (PubMed id 17157788)1 Bruno T....Fanciulli M. (Cancer Cell 2006)
    698. Increased transferrin receptor expression following 11q23 deletion as a mechanism of malignant progression in chronic lymphocytic leukemia. (PubMed id 16326028)1 Shackelford R.E....Lowery-Nordberg M. (Med. Hypotheses 2006)
    699. ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity. (PubMed id 16319535)1 Oricchio E....Cundari E. (Cell Cycle 2006)
    700. Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells. (PubMed id 16951182)1 RodrA-guez-Bravo V....Agell N. (Cancer Res. 2006)
    701. CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM. (PubMed id 16325375)1 Zhang L.... He F. (Cell. Signal. 2006)
    702. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. (PubMed id 16481012)1 Bahassi el M....Stambrook P.J. (Mutat. Res. 2006)
    703. Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity. (PubMed id 16631604)1 Roy K....Price B.D. (Biochem. Biophys. Res. Commun. 2006)
    704. Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function. (PubMed id 16474151)1 Ariumi Y. and Trono D. (J. Virol. 2006)
    705. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. (PubMed id 17124492)1 Stiff T....Jeggo P.A. (EMBO J. 2006)
    706. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. (PubMed id 16905549)1 Takemura H....Pommier Y. (J. Biol. Chem. 2006)
    707. Characterization of the breast cancer associated ATM 7271T&gt;G (V2424G) mutation by gene expression profiling. (PubMed id 17001622)1 Waddell N....Chenevix-Trench G. (amp 2006)
    708. Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation. (PubMed id 16728507)1 Irarrazabal C.E....Ferraris J.D. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    709. Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related- dependent checkpoint pathway promotes cell survival in response to UV irradiation. (PubMed id 16540648)1 Wu X.... Zou Y. (Cancer Res. 2006)
    710. ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. (PubMed id 16931761)1 Dornan D....Dixit V.M. (Science 2006)
    711. Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. (PubMed id 16794575)1 Oliver A.W.... Pearl L.H. (EMBO J. 2006)
    712. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    713. Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. (PubMed id 16943424)1 Pereg Y....Jochemsen A.G. (Mol. Cell. Biol. 2006)
    714. ATM and breast cancer susceptibility. (PubMed id 16998505)1 Ahmed M. and Rahman N. (Oncogene 2006)
    715. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. (PubMed id 16452482)1 Aglipay J.A.... Ouchi T. (J. Biol. Chem. 2006)
    716. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. (PubMed id 16327781)1 Jazayeri A....Jackson S.P. (Nat. Cell Biol. 2006)
    717. p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress. (PubMed id 16705183)1 Eymin B....Gazzeri S. (Mol. Cell. Biol. 2006)
    718. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. (PubMed id 16432227)1 Pusapati R.V....Johnson D.G. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    719. p53 stabilization and transactivation by a von Hippel-Lindau protein. (PubMed id 16678111)1 Roe J.S....Youn H.D. (Mol. Cell 2006)
    720. Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1. (PubMed id 16474133)1 Shin Y.C....Jung J.U. (J. Virol. 2006)
    721. SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. (PubMed id 16651613)1 Nguyen H.V....Ann D.K. (Am. J. Pathol. 2006)
    722. Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. (PubMed id 16906133)1 Pellegrini M....Nussenzweig A. (Nature 2006)
    723. ATM regulates ATR chromatin loading in response to DNA double-strand breaks. (PubMed id 16461339)1 Cuadrado M....Fernandez-Capetillo O. (J. Exp. Med. 2006)
    724. ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. (PubMed id 16824197)1 Kobayashi M....Yamamoto K. (amp 2006)
    725. Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. (PubMed id 16474843)1 Adams K.E....Lakin N.D. (Oncogene 2006)
    726. Wip1 phosphatase modulates ATM-dependent signaling pathways. (PubMed id 16949371)1 Shreeram S....Bulavin D.V. (Mol. Cell 2006)
    727. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. (PubMed id 17178844)1 Nyati M.K....Lawrence T.S. (Cancer Res. 2006)
    728. Ataxia-telangiectasia-mutated-dependent activation of Ku in human fibroblasts exposed to hydrogen peroxide. (PubMed id 17341604)1 Lee J.H....Kim H. (Ann. N. Y. Acad. Sci. 2006)
    729. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. (PubMed id 16431910)1 Myers J.S. and Cortez D. (J. Biol. Chem. 2006)
    730. ATR dependent activation of Chk2. (PubMed id 16741947)1 Wang X.Q....Stanbridge E.J. (J. Cell. Physiol. 2006)
    731. Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes. (PubMed id 17106266)1 Tanaka T....Darzynkiewicz Z. (Cell Cycle 2006)
    732. TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner. (PubMed id 17172861)1 Zhang S....LandstrAPm M. (Cell Cycle 2006)
    733. HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT. (PubMed id 17140287)1 Andersen J.L....Planelles V. (PLoS Pathog. 2006)
    734. Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells. (PubMed id 16627474)1 Biton S....Shiloh Y. (J. Biol. Chem. 2006)
    735. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. (PubMed id 16497931)1 Wu Z.H.... Miyamoto S. (Science 2006)
    736. ATM gene founder haplotypes and associated mutations in Polish families with ataxia-telangiectasia. (PubMed id 16266405)1 Mitui M....Gatti R.A. (Ann. Hum. Genet. 2005)
    737. Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors. (PubMed id 15389585)1 Wang H....Iliakis G. (J. Cell. Physiol. 2005)
    738. Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. (PubMed id 15929992)1 Young D.B....Khanna K.K. (J. Biol. Chem. 2005)
    739. Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. (PubMed id 15632067)1 Kang J....Xu Y. (Mol. Cell. Biol. 2005)
    740. ATM activation in normal human tissues and testicular cancer. (PubMed id 15846060)1 Bartkova J....Bartek J. (Cell Cycle 2005)
    741. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. (PubMed id 15758953)1 Falck J.... Jackson S.P. (Nature 2005)
    742. Ataxia telangiectasia-mutated, a DNA damage-inducible kinase, contributes to high NaCl-induced nuclear localization of transcription factor TonEBP/OREBP. (PubMed id 15840767)1 Zhang Z....Burg M.B. (Am. J. Physiol. Renal Physiol. 2005)
    743. A role for proapoptotic BID in the DNA-damage response. (PubMed id 16122425)1 Zinkel S.S....Korsmeyer S.J. (Cell 2005)
    744. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. (PubMed id 15790808)1 Lee J.H. and Paull T.T. (Science 2005)
    745. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. (PubMed id 15533933)1 Helt C.E....O'Reilly M.A. (J. Biol. Chem. 2005)
    746. Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage. (PubMed id 15788536)1 Pereg Y....Shiloh Y. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    747. Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. (PubMed id 16221684)1 Shi Y....Tibbetts R.S. (J. Biol. Chem. 2005)
    748. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. (PubMed id 15964794)1 You Z....Russell P. (Mol. Cell. Biol. 2005)
    749. Activation of ataxia telangiectasia-mutated DNA damage checkpoint signal transduction elicited by herpes simplex virus infection. (PubMed id 15964848)1 Shirata N....Tsurumi T. (J. Biol. Chem. 2005)
    750. Rheb binds and regulates the mTOR kinase. (PubMed id 15854902)1 Long X.... Avruch J. (Curr. Biol. 2005)
    751. ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. (PubMed id 16082221)1 Meulmeester E....Jochemsen A.G. (Cell Cycle 2005)
    752. Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks. (PubMed id 15546858)1 Ismail I.H....Hammarsten O. (J. Biol. Chem. 2005)
    753. Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S.... Mann M. (Nature 2005)
    754. Proapoptotic BID is an ATM effector in the DNA-damage response. (PubMed id 16122426)1 Kamer I....Gross A. (Cell 2005)
    755. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. (PubMed id 15611093)1 Kudoh A....Tsurumi T. (J. Biol. Chem. 2005)
    756. ATM expression in rectal cancers with or without preoperative radiotherapy. (PubMed id 16012708)1 Arlehag L....Sun X.F. (Oncol. Rep. 2005)
    757. ATM is required for the cellular response to thymidine induced replication fork stress. (PubMed id 15459181)1 Bolderson E....Meuth M. (Hum. Mol. Genet. 2004)
    758. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    759. Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. (PubMed id 15489221)1 Kurz E.U.... Lees-Miller S.P. (J. Biol. Chem. 2004)
    760. Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. (PubMed id 15210935)1 Cortez D.... Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    761. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    762. Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns. (PubMed id 14745549)1 Jang E.R....Lee J.S. (J. Cancer Res. Clin. Oncol. 2004)
    763. Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. (PubMed id 15199141)1 Wang X.Z.... D'Andrea A.D. (Mol. Cell. Biol. 2004)
    764. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. (PubMed id 14570874)1 Naka K....Motoyama N. (J. Biol. Chem. 2004)
    765. Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress. (PubMed id 15073328)1 Shi Y....Tibbetts R.S. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    766. Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells. (PubMed id 14744854)1 Golding S.E....Valerie K. (J. Biol. Chem. 2004)
    767. IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. (PubMed id 15485651)1 Suzuki A....Esumi H. (Biochem. Biophys. Res. Commun. 2004)
    768. ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. (PubMed id 14966265)1 Panta G.R....Arsura M. (Mol. Cell. Biol. 2004)
    769. Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX. (PubMed id 15284180)1 Ha L....Patierno S.R. (Carcinogenesis 2004)
    770. The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm. (PubMed id 15542845)1 Shima N....Schimenti J.C. (Mol. Cell. Biol. 2004)
    771. The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. (PubMed id 15314656)1 Karlseder J....de Lange T. (PLoS Biol. 2004)
    772. DNA damage-induced activation of ATM and ATM-dependent signaling pathways. (PubMed id 15279774)1 Kurz E.U. and Lees-Miller S.P. (DNA Repair (Amst.) 2004)
    773. ATM mutations in B-cell chronic lymphocytic leukemia. (PubMed id 14754616)1 LAohdesmAoki A....HammarstrAPm L. (Haematologica 2004)
    774. 53BP1, an activator of ATM in response to DNA damage. (PubMed id 15279780)1 Mochan T.A....Halazonetis T.D. (DNA Repair (Amst.) 2004)
    775. An investigation into the human serum &quot;interactome&quot;. (PubMed id 15174051)1 Zhou M....Conrads T.P. (Electrophoresis 2004)
    776. The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. (PubMed id 15175154)1 Brumbaugh K.M.... Abraham R.T. (Mol. Cell 2004)
    777. DNA variants in the ATM gene are not associated with sporadic rectal cancer in a Norwegian population-based study. (PubMed id 12827413)4 Kristensen A.T....m P.O. (Int J Colorectal Dis 2004)
    778. ATM activity contributes to the tumor-suppressing functions of p14ARF. (PubMed id 15258567)1 Li Y....Tang D. (Oncogene 2004)
    779. Alteration of the ATM gene occurs in gastric cancer cell lines and primary tumors associated with cellular response to DNA damage. (PubMed id 14706517)4 Zhang L....Lu Y.Y. (Mutat. Res. 2004)
    780. BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. (PubMed id 15159397)1 Fabbro M....Khanna K.K. (J. Biol. Chem. 2004)
    781. Protein kinase Cdelta is responsible for constitutive and DNA damage- induced phosphorylation of Rad9. (PubMed id 12628935)1 Yoshida K.... Kufe D. (EMBO J. 2003)
    782. ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation. (PubMed id 12645530)1 Kozlov S....Lavin M.F. (J. Biol. Chem. 2003)
    783. DNA damage induced by polyglutamine-expanded proteins. (PubMed id 12915485)1 Giuliano P....Varrone S. (Hum. Mol. Genet. 2003)
    784. Histone deacetylase inhibitors activate p21(WAF1) expression via ATM. (PubMed id 12782595)1 Ju R. and Muller M.T. (Cancer Res. 2003)
    785. The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. (PubMed id 12588975)1 Wang X.... Proud C.G. (Mol. Cell. Biol. 2003)
    786. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. (PubMed id 12861053)1 Lee J.H....Lim D.S. (Mol. Cancer Res. 2003)
    787. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. (PubMed id 14519663)1 Xu X. and Stern D.F. (FASEB J. 2003)
    788. Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias. (PubMed id 12875964)1 Starczynski J....Murray P.G. (Am. J. Pathol. 2003)
    789. Human tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. (PubMed id 12660173)1 Groth A....Hansen K. (EMBO J. 2003)
    790. ATM mutations and protein expression are not associated with familial B-CLL cases. (PubMed id 12860021)1 Ishibe N....Marti G.E. (Leuk. Res. 2003)
    791. Aberrant sensing of extracellular Ca2+ by cultured ataxia telangiectasia fibroblasts. (PubMed id 12545170)1 Famulski K.S....Paterson M.C. (Oncogene 2003)
    792. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. (PubMed id 14499622)1 Reuter T.Y....Huber P.A. (Exp. Cell Res. 2003)
    793. ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region. (PubMed id 12646636)1 Pan-HammarstrAPm Q....HammarstrAPm L. (J. Immunol. 2003)
    794. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. (PubMed id 14695167)1 Mochan T.A.... Halazonetis T.D. (Cancer Res. 2003)
    795. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. (PubMed id 12540856)1 Wong K.K....DePinho R.A. (Nature 2003)
    796. Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest. (PubMed id 12637545)1 Ha L....Patierno S.R. (J. Biol. Chem. 2003)
    797. Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma. (PubMed id 12673126)1 Zhang P....Wang J.Y. (amp 2003)
    798. Requirement of the MRN complex for ATM activation by DNA damage. (PubMed id 14532133)1 Uziel T....Shiloh Y. (EMBO J. 2003)
    799. MDC1 is required for the intra-S-phase DNA damage checkpoint. (PubMed id 12607003)1 Goldberg M.... Jackson S.P. (Nature 2003)
    800. Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. (PubMed id 12493754)1 Tsvetkov L....Stern D.F. (J. Biol. Chem. 2003)
    801. The Mre11 complex is required for ATM activation and the G2/M checkpoint. (PubMed id 14657032)1 Carson C.T....Weitzman M.D. (EMBO J. 2003)
    802. Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement. (PubMed id 12511424)1 Oguchi K....Mizutani S. (Blood 2003)
    803. Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells. (PubMed id 12650908)1 Yuan S.S....Lee E.Y. (Mutat. Res. 2003)
    804. MDC1 is a mediator of the mammalian DNA damage checkpoint. (PubMed id 12607005)1 Stewart G.S.... Elledge S.J. (Nature 2003)
    805. Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA. (PubMed id 12813460)1 Llorca O....Willison K.R. (Oncogene 2003)
    806. Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2. (PubMed id 12833146)1 Kool J....van Dam H. (Oncogene 2003)
    807. Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling. (PubMed id 12709442)1 Roos-Mattjus P.... Karnitz L.M. (J. Biol. Chem. 2003)
    808. Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. (PubMed id 11853558)1 Sapkota G.P....Alessi D.R. (Biochem. J. 2002)
    809. Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line. (PubMed id 12032824)1 Kim W.-J.... Brown K.D. (Oncogene 2002)
    810. Histone H2A variants H2AX and H2AZ. (PubMed id 11893489)1 Redon C....Bonner W. (amp 2002)
    811. Chk2 activation and phosphorylation-dependent oligomerization. (PubMed id 12024051)1 Xu X....Stern D.F. (Mol. Cell. Biol. 2002)
    812. A late onset variant of ataxia-telangiectasia with a compound heterozygous genotype, A8030G/7481insA. (PubMed id 11826028)1 Saviozzi S....Brusco A. (J. Med. Genet. 2002)
    813. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    814. ATR regulates fragile site stability. (PubMed id 12526805)1 Casper A.M.... Glover T.W. (Cell 2002)
    815. Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway. (PubMed id 12420214)1 Pamment J....Ball K.L. (Oncogene 2002)
    816. Variation in breast cancer risk of heterozygotes for ataxia-telangiectasia according to environmental factors. (PubMed id 11992555)1 Geoffroy-Perez B....Andrieu N. (Int. J. Cancer 2002)
    817. Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells. (PubMed id 12065055)1 Yoshida M....Ono T. (Int. J. Radiat. Biol. 2002)
    818. ATM mutations in Finnish breast cancer patients. (PubMed id 11897822)1 Allinen M....Winqvist R. (J. Med. Genet. 2002)
    819. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. (PubMed id 11780126)1 D'Orazi G.... Soddu S. (Nat. Cell Biol. 2002)
    820. Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead- associated domain. (PubMed id 11901158)1 Ahn J.Y.... Canman C.E. (J. Biol. Chem. 2002)
    821. ATM: from phenotype to functional genomics--and back. (PubMed id 11859564)1 Shiloh Y. (Ernst Schering Res. Found. Workshop 2002)
    822. Deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the ATM gene. (PubMed id 12376469)1 Hannan M.A....Aboussekhra A. (Carcinogenesis 2002)
    823. Consortium piecing together role of ATM gene in breast cancer. (PubMed id 11830600)1 Finkel E. (J. Natl. Cancer Inst. 2002)
    824. ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation. (PubMed id 12151394)1 Adamson A.W....Brown K.D. (J. Biol. Chem. 2002)
    825. Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display. (PubMed id 12549820)1 TrzciA8ska A.M....StaroA8 K. (Mol. Biol. Rep. 2002)
    826. Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways. (PubMed id 12242661)1 Bahassi el M.... Stambrook P.J. (Oncogene 2002)
    827. Constitutional alterations of the ATM gene in early onset sporadic breast cancer. (PubMed id 12362033)1 Maillet P....Sappino A.P. (J. Med. Genet. 2002)
    828. Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes. (PubMed id 12036888)1 Korz C....Lichter P. (Blood 2002)
    829. A new type of mutation causes a splicing defect in ATM. (PubMed id 11889466)1 Pagani F....Baralle F.E. (Nat. Genet. 2002)
    830. Cellular responses to the DNA strand-scission enediyne C-1027 can be independent of ATM, ATR, and DNA-PK kinases. (PubMed id 11927575)1 Dziegielewski J. and Beerman T.A. (J. Biol. Chem. 2002)
    831. Re: Dominant negative ATM mutations in breast cancer families. (PubMed id 12072552)1 Lei H....Vorechovsky I. (J. Natl. Cancer Inst. 2002)
    832. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. (PubMed id 12447390)1 Fernandez-Capetillo O....Nussenzweig A. (Nat. Cell Biol. 2002)
    833. Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. (PubMed id 11943150)1 Nakamura M.... Ping Lu K. (FEBS Lett. 2002)
    834. ATM mutations are rare in familial chronic lymphocytic leukemia. (PubMed id 12091354)1 Yuille M.R....Houlston R.S. (Blood 2002)
    835. Degradation of ATM-independent decatenation checkpoint function in human cells is secondary to inactivation of p53 and correlated with chromosomal destabilization. (PubMed id 12429935)1 Kaufmann W.K....Downes C.S. (Cell Cycle 2002)
    836. ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation. (PubMed id 11723136)1 Guo C.Y....Larner J.M. (J. Biol. Chem. 2002)
    837. Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses. (PubMed id 11158303)1 Daniel R....Skalka A.M. (Mol. Cell. Biol. 2001)
    838. UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. (PubMed id 11709713)1 Latonen L....Laiho M. (Oncogene 2001)
    839. Novel mutations and defective protein kinase C activation of T- lymphocytes in ataxia telangiectasia. (PubMed id 11298136)1 Garcia-Perez M.A.... Arnaiz-Villena A. (Clin. Exp. Immunol. 2001)
    840. ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. (PubMed id 11331603)1 Maya R....Oren M. (amp 2001)
    841. ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation. (PubMed id 11278446)1 Chen M.J....Lee E.Y. (J. Biol. Chem. 2001)
    842. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. (PubMed id 11571274)1 Burma S....Chen D.J. (J. Biol. Chem. 2001)
    843. Effect of DNA damage on a BRCA1 complex. (PubMed id 11689934)1 Wu-Baer F. and Baer R. (Nature 2001)
    844. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. (PubMed id 11459832)1 Lin W.C....Nevins J.R. (amp 2001)
    845. Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development. (PubMed id 11238919)1 MAcnisser-de Murcia J....de Murcia G. (Mol. Cell. Biol. 2001)
    846. The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. (PubMed id 11290740)1 Shackelford R.E....Paules R.S. (J. Biol. Chem. 2001)
    847. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. (PubMed id 11390642)1 Zhao H. and Piwnica-Worms H. (Mol. Cell. Biol. 2001)
    848. Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. (PubMed id 11551930)1 Xie S.... Dai W. (J. Biol. Chem. 2001)
    849. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. (PubMed id 10673501)1 Shieh S.-Y.... Prives C. (Genes Dev. 2000)
    850. Role for ATM in DNA damage-induced phosphorylation of BRCA1. (PubMed id 10866324)1 Gatei M....Khanna K.K. (Cancer Res. 2000)
    851. The many substrates and functions of ATM. (PubMed id 11252893)1 Kastan M.B. and Lim D.S. (Nat. Rev. Mol. Cell Biol. 2000)
    852. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. (PubMed id 10959836)1 Paull T.T....Bonner W.M. (Curr. Biol. 2000)
    853. Substrate specificities and identification of putative substrates of ATM kinase family members. (PubMed id 10608806)1 Kim S.-T.... Kastan M.B. (J. Biol. Chem. 1999)
    854. High incidence of cancer in a family segregating a mutation of the ATM gene: possible role of ATM heterozygosity in cancer. (PubMed id 10571946)1 Bay J.O....Bignon Y.J. (Hum. Mutat. 1999)
    855. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. (PubMed id 10212258)1 Chen G....Lee E.Y. (J. Biol. Chem. 1999)
    856. Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase. (PubMed id 10531300)1 Kim G.D....Jung M. (J. Biol. Chem. 1999)
    857. A role for ATR in the DNA damage-induced phosphorylation of p53. (PubMed id 9925639)1 Tibbetts R.S.... Abraham R.T. (Genes Dev. 1999)
    858. Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. (PubMed id 10464290)1 Suzuki K....Watanabe M. (J. Biol. Chem. 1999)
    859. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. (PubMed id 9488723)1 Rogakou E.P.... Bonner W.M. (J. Biol. Chem. 1998)
    860. The complexity of p53 modulation: emerging patterns from divergent signals. (PubMed id 9765199)1 Giaccia A.J. and Kastan M.B. (amp 1998)
    861. Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111). (PubMed id 9806882)1 Heesom K.J....Denton R.M. (Biochem. J. 1998)
    862. Identical mutation in 55% of the ATM alleles in 11 Norwegian AT families: evidence for a founder effect. (PubMed id 9781027)1 Laake K....rresen-Dale A.L. (Eur. J. Hum. Genet. 1998)
    863. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. (PubMed id 9836640)1 Matsuoka S.... Elledge S.J. (Science 1998)
    864. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. (PubMed id 9168116)1 Baskaran R....Wang J.Y. (Nature 1997)
    865. Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints. (PubMed id 9135004)1 Westphal C.H....Leder P. (Cancer Res. 1997)
    866. The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. (PubMed id 7644499)1 Brzoska P.M.... Christman M.F. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    867. Del(12)(p11.21p12.2) associated with an asphyxiating thoracic dystrophy or chondroectodermal dysplasia-like syndrome. (PubMed id 7702088)1 Nagai T....Fukushima Y. (Am. J. Med. Genet. 1995)
    868. BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer (PubMed id 20301425)1 Pagon R.A....Stephens K. (1993)
    869. Ataxia-Telangiectasia (PubMed id 20301790)1 Pagon R.A....Stephens K. (1993)
    870. Comparison of collagen propeptides as growth markers in children with inflammatory bowel disease. (PubMed id 2001833)1 Hyams J.S....Moore R.E. (Gastroenterology 1991)
    871. ATFresno: a phenotype linking ataxia-telangiectasia with the Nijmegen breakage syndrome. (PubMed id 2491181)1 Curry C.J....Hutchinson H.T. (Am. J. Hum. Genet. 1989)
    872. Localization of an ataxia-telangiectasia gene to chromosome 11q22-23. (PubMed id 3200306)1 Gatti R.A....Lange K. (Nature 1988)
    873. Rapid radiation-induction of ATM protein levels in situ. (PubMed id 11280605)9 Fang Z.M....Clarke R.A. (Pathology 2001)
    874. Single-cell analysis of loss of heterozygosity at the ATM gene locus in Hodgkin and Reed-Sternberg cells of Hodgkin's lymphoma: ATM loss of heterozygosity is a rare event. (PubMed id 15645496)9 Lespinet V....Al Saati T. (Int. J. Cancer 2005)
    875. A mathematical model for the detection mechanism of DNA double-strand breaks depending on autophosphorylation of ATM. (PubMed id 19365581)9 Mouri K....Akutsu T. (PLoS ONE 2009)
    876. Involvement of ATM missense variants and mutations in a series of unselected breast cancer cases. (PubMed id 11793440)9 Rodriguez C....Theillet C. (amp 2002)
    877. X-irradiation induces up-regulation of ATM gene expression in wild-type lymphoblastoid cell lines, but not in their heterozygous or homozygous ataxia-telangiectasia counterparts. (PubMed id 11429062)9 Hirai Y....Seyama T. (Jpn. J. Cancer Res. 2001)
    878. ATM gene deletion in patients with adult acute lymphoblastic leukemia. (PubMed id 10699895)9 Haidar M.A....Albitar M. (Cancer 2000)
    879. Deficiency of the ATM protein expression defines an aggressive subgroup of B-cell chronic lymphocytic leukemia. (PubMed id 9788599)9 Starostik P....Albitar M. (Cancer Res. 1998)
    880. Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. (PubMed id 9000145)9 Lakin N.D....Jackson S.P. (Oncogene 1996)
    881. Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53. (PubMed id 16849690)9 Wang J....Dong Z. (Am. J. Physiol. Renal Physiol. 2006)
    882. [Interaction between ATM and radiation-activated phosphorylation of P53 and P21]. (PubMed id 16159425)9 Luo J.L....Zheng S.Y. (Ai Zheng 2005)
    883. ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture. (PubMed id 11380241)9 Tribius S....Casper D. (Int. J. Radiat. Oncol. Biol. Phys. 2001)
    884. ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia. (PubMed id 10549596)9 Lavin M.F. and Khanna K.K. (Int. J. Radiat. Biol. 1999)
    885. Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background. (PubMed id 18679420)9 Mao J.H....Perez-Losada J. (Oncogene 2008)
    886. ATM activation and DNA damage response. (PubMed id 17457059)9 Lavin M.F. and Kozlov S. (Cell Cycle 2007)
    887. ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells. (PubMed id 10477729)9 Fukao T....Lavin M.F. (Blood 1999)
    888. ATMINistrating ATM signalling: regulation of ATM by ATMIN. (PubMed id 19001856)9 Kanu N. and Behrens A. (Cell Cycle 2008)
    889. Constitutive expression and cytoplasmic compartmentalization of ATM protein in differentiated human neuron-like SH-SY5Y cells. (PubMed id 17241156)9 Boehrs J.K....Yang D.Q. (J. Neurochem. 2007)
    890. Variation of ATM protein expression in response to irradiation of lymphocytes in lung cancer patients and controls. (PubMed id 16737764)9 Jianlin L....Shijie X. (Toxicology 2006)
    891. Expression of ATM protein and its relationship with p53 in pancreatic carcinoma with tissue array. (PubMed id 15097860)9 Yu G....Li F.M. (Pancreas 2004)
    892. TEL1 from Saccharomyces cerevisiae suppresses chromosome aberrations induced by ionizing radiation in ataxia-telangiectasia cells without affecting cell cycle checkpoints. (PubMed id 11820740)9 Cao J.P....Fritz E. (Radiat Environ Biophys 2001)
    893. Influence of ATM function on interactions between telomeres and nuclear matrix. (PubMed id 10931683)9 Pandita T.K. and Dhar S. (Radiat. Res. 2000)
    894. Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. (PubMed id 9725899)9 Gately D.P....Yen T.J. (Mol. Biol. Cell 1998)
    895. Influence of ATM function on telomere metabolism. (PubMed id 9400992)9 Smilenov L.B....Pandita T.K. (Oncogene 1997)
    896. Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition. (PubMed id 17459151)9 Aguilar-Quesada R....Oliver F.J. (BMC Mol. Biol. 2007)
    897. The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM. (PubMed id 15908798)9 Paull T.T. and Lee J.H. (Cell Cycle 2005)
    898. Improved diagnostic testing for ataxia-telangiectasia by immunoblotting of nuclear lysates for ATM protein expression. (PubMed id 14654357)9 Chun H.H....Gatti R.A. (Mol. Genet. Metab. 2003)
    899. ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response. (PubMed id 14508513)9 Chen S....Price B.D. (Oncogene 2003)
    900. ATM induction insufficiency in a radiosensitive breast-cancer patient. (PubMed id 12196249)9 Clarke R.A....Papadatos G. (Australas Radiol 2002)
    901. Nuclear retention of ATM at sites of DNA double strand breaks. (PubMed id 11454856)9 Andegeko Y....Rotman G. (J. Biol. Chem. 2001)
    902. Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53. (PubMed id 11526498)9 Turenne G.A....Price B.D. (Oncogene 2001)
    903. Ataxia telangiectasia gene mutations in leukaemia and lymphoma. (PubMed id 11429421)9 Boultwood J. (J. Clin. Pathol. 2001)
    904. ATM protein synthesis patterns in sporadic breast cancer. (PubMed id 10748873)9 Kairouz R....Lee C.S. (MP, Mol. Pathol. 1999)
    905. Human fibroblasts transfected with an ATM antisense vector respond abnormally to ionizing radiation. (PubMed id 10373636)9 Uhrhammer N....Meyn M.S. (Int. J. Mol. Med. 1999)
    906. Cytoplasmic ATM in neurons modulates synaptic function. (PubMed id 19962314)9 Li J....Herrup K. (Curr. Biol. 2009)
    907. Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis. (PubMed id 16528736)9 Huang X....Darzynkiewicz Z. (Cytometry A 2006)
    908. ATM and genome maintenance: defining its role in breast cancer susceptibility. (PubMed id 15557798)9 Khanna K.K. and Chenevix-Trench G. (J Mammary Gland Biol Neoplasia 2004)
    909. Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade. (PubMed id 15138484)9 Ding S.L....Shen C.Y. (Br. J. Cancer 2004)
    910. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. (PubMed id 8843195)9 Keegan K.S.... Hoekstra M.F. (Genes Dev. 1996)
    911. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. (PubMed id 20304914)9 Sakasai R....Tibbetts R.S. (J. Biol. Chem. 2010)
    912. PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. (PubMed id 19717351)9 Carrozza M.J....Wilson S.H. (DNA Repair (Amst.) 2009)
    913. The impact of heterochromatin on DSB repair. (PubMed id 19442252)9 Goodarzi A.A....Jeggo P.A. (Biochem. Soc. Trans. 2009)
    914. Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. (PubMed id 18408079)9 Rimkus S.A....Wassarman D.A. (amp 2008)
    915. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. (PubMed id 15753361)9 Peng Y....Bedford J.S. (Cancer Res. 2005)
    916. Functional expression of ATM gene carried by HSV amplicon vector in vitro and in vivo. (PubMed id 14681694)9 Qi J....Wang S. (Gene Ther. 2004)
    917. Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. (PubMed id 15448142)9 Yoo H.Y....Dunphy W.G. (J. Biol. Chem. 2004)
    918. [Relationship between ataxia telangiectasia mutant(ATM) expression of HL-60 and SiHA cell lines and their cell cycle arrest after 60Co radiation]. (PubMed id 12866959)9 Tang Y....Wu J.H. (Ai Zheng 2003)
    919. Global analysis of ATM polymorphism reveals significant functional constraint. (PubMed id 11443540)9 Thorstenson Y.R....Oefner P.J. (Am. J. Hum. Genet. 2001)
    920. Abnormal expression of the ATM and TP53 genes in sporadic breast carcinomas. (PubMed id 10999741)9 AngA"le S....Hall J. (Clin. Cancer Res. 2000)
    921. ATM protein and p53-serine 15 phosphorylation in ataxia-telangiectasia (AT) patients and at heterozygotes. (PubMed id 10864201)9 Delia D....Chessa L. (Br. J. Cancer 2000)
    922. The ATM gene and breast cancer: is it really a risk factor? (PubMed id 10767628)9 AngA"le S. and Hall J. (Mutat. Res. 2000)
    923. Absence of mutations in ATM, the gene responsible for ataxia telangiectasia in patients with cerebellar ataxia. (PubMed id 10460451)9 Hassin-Baer S....Shiloh Y. (J. Neurol. 1999)
    924. Ovarian cancer: loss of heterozygosity frequently occurs in the ATM gene, but structural alterations do not occur in this gene. (PubMed id 9949303)9 Koike M....Koeffler H.P. (Oncology 1999)
    925. Ataxia-telangiectasia and T-cell leukemias: no evidence for somatic ATM mutation in sporadic T-ALL or for hypermethylation of the ATM-NPAT/E14 bidirectional promoter in T-PLL. (PubMed id 9622061)9 Luo L....VorechovskA1 I. (Cancer Res. 1998)
    926. Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM. (PubMed id 19541822)9 Alonso R....Colomer D. (Blood 2009)
    927. The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. (PubMed id 19279141)9 Yoo H.Y....Dunphy W.G. (Mol. Biol. Cell 2009)
    928. DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry. (PubMed id 19658174)9 Zhao H....Darzynkiewicz Z. (Cytometry A 2009)
    929. Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation. (PubMed id 18418078)9 Zhao H....Darzynkiewicz Z. (Cell Cycle 2008)
    930. Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression. (PubMed id 17522062)9 Nuciforo P.G....d'Adda di Fagagna F. (Carcinogenesis 2007)
    931. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. (PubMed id 17687332)9 Denchi E.L. and de Lange T. (Nature 2007)
    932. TGFbeta-1 dependent fast stimulation of ATM and p53 phosphorylation following exposure to ionizing radiation does not involve TGFbeta-receptor I signalling. (PubMed id 17560675)9 Wiegman E.M....Rodemann H.P. (Radiother Oncol 2007)
    933. Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia. (PubMed id 15289842)9 Hashiguchi Y....Yamamoto K. (Oncol. Rep. 2004)
    934. NBS1 and its functional role in the DNA damage response. (PubMed id 15279770)9 Kobayashi J....Komatsu K. (DNA Repair (Amst.) 2004)
    935. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. (PubMed id 10485486)9 Sarkaria J.N....Abraham R.T. (Cancer Res. 1999)
    936. AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations. (PubMed id 19898425)9 Leuenberger M....Tinguely M. (Mod. Pathol. 2010)
    937. Prognostic impact of chromosome alterations detected by FISH in Turkish patients with B-cell chronic lymphocytic leukemia. (PubMed id 19100507)9 Durak B....GA1lbas Z. (Cancer Genet. Cytogenet. 2009)
    938. ATR and H2AX cooperate in maintaining genome stability under replication stress. (PubMed id 19049966)9 Chanoux R.A....Brown E.J. (J. Biol. Chem. 2009)
    939. p53 regulates Hsp90beta during arsenite-induced cytotoxicity in glutathione-deficient cells. (PubMed id 18996350)9 Habib G.M. (Arch. Biochem. Biophys. 2009)
    940. Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. (PubMed id 18955500)9 Solier S....Pommier Y. (Mol. Cell. Biol. 2009)
    941. Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. (PubMed id 19351839)9 Ivanov V.N....Hei T.K. (Cancer Res. 2009)
    942. Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex. (PubMed id 18632984)9 Guirouilh-Barbat J....Pommier Y. (Mol. Biol. Cell 2008)
    943. ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells. (PubMed id 18534819)9 Halaby M.J....Yang D.Q. (Cell. Signal. 2008)
    944. The role of ATM in breast cancer development. (PubMed id 17061036)9 Prokopcova J....Pohlreich P. (Breast Cancer Res. Treat. 2007)
    945. Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. (PubMed id 17446169)9 Yoo H.Y....Dunphy W.G. (J. Biol. Chem. 2007)
    946. ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. (PubMed id 16799570)9 Bredemeyer A.L....Sleckman B.P. (Nature 2006)
    947. Relationship between DNA double-strand break rejoining and cell survival after exposure to ionizing radiation in human fibroblast strains with differing ATM/p53 status: implications for evaluation of clinical radiosensitivity. (PubMed id 17126209)9 Mirzayans R....Murray D. (Int. J. Radiat. Oncol. Biol. Phys. 2006)
    948. Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1. (PubMed id 16630610)9 Park I. and Avraham H.K. (Exp. Cell Res. 2006)
    949. Roles of tumor suppressor and telomere maintenance genes in cancer and aging--an epidemiological study. (PubMed id 15905204)9 Gu J....Wu X. (Carcinogenesis 2005)
    950. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. (PubMed id 15665826)9 Bradshaw P.S....Meyn M.S. (Nat. Genet. 2005)
    951. A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival. (PubMed id 15692065)9 Alvi A.J....Stankovic T. (Blood 2005)
    952. DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system. (PubMed id 15322239)9 Caporali S....D'Atri S. (Mol. Pharmacol. 2004)
    953. The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. (PubMed id 15177039)9 Ye R....Lees-Miller S.P. (DNA Repair (Amst.) 2004)
    954. ATM is a target for positive regulation by E2F-1. (PubMed id 12527885)9 Berkovich E. and Ginsberg D. (Oncogene 2003)
    955. Activation of ATM and phosphorylation of p53 by heat shock. (PubMed id 11850826)9 Miyakoda M....Watanabe M. (Oncogene 2002)
    956. Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. (PubMed id 11864911)9 Guo N....Vaziri C. (amp 2002)
    957. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. (PubMed id 11313470)9 Xu B....Kastan M.B. (Mol. Cell. Biol. 2001)
    958. Phosphatidylinositol 3-kinase inhibitors, Wortmannin or LY294002, inhibited accumulation of p21 protein after gamma-irradiation by stabilization of the protein. (PubMed id 10771089)9 Fukuchi K....Gomi K. (Biochim. Biophys. Acta 2000)
    959. Tumor suppressor genes and breast cancer. (PubMed id 10333246)9 Buchholz T.A....McNeese M.D. (Radiat Oncol Investig 1999)
    960. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. (PubMed id 10570149)9 Chehab N.H.... Halazonetis T.D. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    961. Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy. (PubMed id 9413938)9 Appleby J.M....Scott D. (Br. J. Cancer 1997)
    962. The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. (PubMed id 8986766)9 Brush G.S....Kelly T.J. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    963. NKX3.1 activates cellular response to DNA damage. (PubMed id 20395202)9 Bowen C. and Gelmann E.P. (Cancer Res. 2010)
    964. Most morphologic features in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) do not reliably predict underlying FISH genetics or immunoglobulin heavy chain variable region somatic mutational status. (PubMed id 19826250)9 Garcia C.F....Reichard K.K. (amp 2010)
    965. Mechanism of p53 stabilization by ATM after DNA damage. (PubMed id 20081365)9 Cheng Q. and Chen J. (Cell Cycle 2010)
    966. Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response. (PubMed id 19416980)9 Zhang Y.W....Pommier Y. (J. Biol. Chem. 2009)
    967. Presence of heterozygous ATM deletion may not be critical in the primary response of chronic lymphocytic leukemia cells to fludarabine. (PubMed id 19018867)9 Cejkova S....Trbusek M. (Eur. J. Haematol. 2009)
    968. Suppression of the DNA damage response in acute myeloid leukemia versus myelodysplastic syndrome. (PubMed id 19398952)9 Boehrer S....Kroemer G. (Oncogene 2009)
    969. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. (PubMed id 19633668)9 Rass E....Lopez B.S. (amp 2009)
    970. [Gene atm and chronic lymphocytic leukemia - review]. (PubMed id 18928637)9 Zhu D.X....Li J.Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    971. The Wip1 phosphatase and Mdm2: cracking the &quot;Wip&quot; on p53 stability. (PubMed id 18333294)9 Lu X....Donehower L.A. (Cell Cycle 2008)
    972. The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression. (PubMed id 18347248)9 Shaw R.J....Risk J.M. (amp 2008)
    973. ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks. (PubMed id 17405860)9 Vacchio M.S....Hodes R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    974. Function of the ATR N-terminal domain revealed by an ATM/ATR chimera. (PubMed id 17376433)9 Chen X....Cortez D. (Exp. Cell Res. 2007)
    975. Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases. (PubMed id 17563356)9 Smolka M.B....Zhou H. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    976. Activation of ATM-dependent DNA damage signal pathway by a histone deacetylase inhibitor, trichostatin A. (PubMed id 19746219)9 Lee J.S. (Cancer Res Treat 2007)
    977. Bulky lymphadenopathy with poor clinical outcome is associated with ATM downregulation in B-cell chronic lymphocytic leukemia patients irrespective of 11q23 deletion. (PubMed id 17213020)9 Joshi A.D....Joshi S.S. (Cancer Genet. Cytogenet. 2007)
    978. The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. (PubMed id 17429352)9 Stracker T.H....Petrini J.H. (Nature 2007)
    979. The predictive value of molecular markers (p53, EGFR, ATM, CHK2) in multimodally treated squamous cell carcinoma of the oesophagus. (PubMed id 17940507)9 Sarbia M....BrA1cher B.L. (Br. J. Cancer 2007)
    980. Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. (PubMed id 17151099)9 Luo M.H....Fortunato E.A. (J. Virol. 2007)
    981. Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability. (PubMed id 16542220)9 Ham M.F....Aozasa K. (Cancer Sci. 2006)
    982. DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. (PubMed id 16567133)9 Mukherjee B....Burma S. (DNA Repair (Amst.) 2006)
    983. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. (PubMed id 16874298)9 Goodarzi A.A....Lees-Miller S.P. (EMBO J. 2006)
    984. DHPLC screening of ATM gene in Italian patients affected by ataxia-telangiectasia: fourteen novel ATM mutations. (PubMed id 17124347)9 Magliozzi M....Chessa L. (Dis. Markers 2006)
    985. Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. (PubMed id 16479016)9 Petersen P....Walter G. (Mol. Cell. Biol. 2006)
    986. The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons. (PubMed id 15699047)9 Flatten K....Kaufmann S.H. (J. Biol. Chem. 2005)
    987. Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines. (PubMed id 15840517)9 Nunnari G....Daniel R. (Virology 2005)
    988. [Fanconi anemia: genes and function(s) revisited]. (PubMed id 16115458)9 Papadopoulo D. and Moustacchi E. (Med Sci (Paris) 2005)
    989. Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival. (PubMed id 16126823)9 Karnitz L.M....Kaufmann S.H. (Mol. Pharmacol. 2005)
    990. [Mucinous noncystic (colloid) adenocarcinoma of the pancreas]. (PubMed id 16251039)9 Zhu M.H....Yu G.Z. (Zhonghua Bing Li Xue Za Zhi 2005)
    991. Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms. (PubMed id 15526025)9 Tort F....Campo E. (Leukemia 2005)
    992. MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder. (PubMed id 15269180)9 Delia D....Chessa L. (Hum. Mol. Genet. 2004)
    993. Transient and reversible deoxyribonucleic acid damage in human left ventricle under controlled ischemia and reperfusion. (PubMed id 15172403)9 Corbucci G.G....Avvedimento E.V. (J. Am. Coll. Cardiol. 2004)
    994. Differential association of BRCA1 and BRCA2 genes with some breast cancer-associated genes in early and late onset breast tumors. (PubMed id 15576832)9 Chunder N....Panda C.K. (Ann. Surg. Oncol. 2004)
    995. Molecular cloning and characterization of the catalytic domain of zebrafish homologue of the ataxia-telangiectasia mutated gene. (PubMed id 15235110)9 Garg R....Xu B. (Mol. Cancer Res. 2004)
    996. ATM-dependent CHK2 activation induced by anticancer agent, irofulven. (PubMed id 15269203)9 Wang J....Wang W. (J. Biol. Chem. 2004)
    997. Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis. (PubMed id 15279810)9 Taylor A.M....Byrd P.J. (DNA Repair (Amst.) 2004)
    998. ATM Gene Mutations Detection in Iranian Ataxia-Telangiectasia Patients. (PubMed id 17301393)9 Sanati M.H....Moin M. (Iran J Allergy Asthma Immunol 2004)
    999. Phosphorylation of serine 18 regulates distinct p53 functions in mice. (PubMed id 14729946)9 Sluss H.K....Jones S.N. (Mol. Cell. Biol. 2004)
    1000. Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype. (PubMed id 14985700)9 Fukao T....Lavin M.F. (Oncogene 2004)
    1001. Radiosensitivity is predicted by DNA end-binding complex density, but not by nuclear levels of band components. (PubMed id 15450732)9 Ismail S.M....Stevens C.W. (Radiother Oncol 2004)
    1002. Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. (PubMed id 15386372)9 Bai A.H....Leung W.K. (Int. J. Cancer 2004)
    1003. Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer. (PubMed id 12673797)9 Bernstein J.L....Concannon P. (Hum. Mutat. 2003)
    1004. Low thymic output and reduced heterogeneity of alpha/beta, but not gamma/delta, T lymphocytes in infants with ataxia-telangiectasia. (PubMed id 12910443)9 Micheli R....Imberti L. (Neuropediatrics 2003)
    1005. Six novel ATM mutations in Italian patients with classical ataxia-telangiectasia. (PubMed id 12655570)9 Saviozzi S....Chessa L. (Hum. Mutat. 2003)
    1006. Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation. (PubMed id 12805407)9 Schwarz J.K....Piwnica-Worms H. (Mol. Cancer Res. 2003)
    1007. The mismatch repair system is required for S-phase checkpoint activation. (PubMed id 12447371)9 Brown K.D....Baskaran R. (Nat. Genet. 2003)
    1008. Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains. (PubMed id 12496286)9 Weizman N....Barzilai A. (J. Biol. Chem. 2003)
    1009. Alteration of G2 cell cycle regulators occurs during carcinogenesis of the endometrium. (PubMed id 12931023)9 Tsuda H....Yamamoto K. (Oncology 2003)
    1010. Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair. (PubMed id 11889050)9 Kang J....Xu Y. (EMBO J. 2002)
    1011. CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas. (PubMed id 12393693)9 Tort F....Campo E. (Blood 2002)
    1012. Upregulation of FasL and apoptosis in thymic lymphomas in Atm knock-in mice. (PubMed id 12505357)9 Lavin M.F. and Spring K. (Toxicology 2002)
    1013. Breakpoints in the ataxia telangiectasia gene arise at the RGYW somatic hypermutation motif. (PubMed id 11821961)9 Bradshaw P.S....Yuille M.R. (Oncogene 2002)
    1014. Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. (PubMed id 12195425)9 Spring K....Lavin M.F. (Nat. Genet. 2002)
    1015. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. (PubMed id 11850621)9 Falck J....Bartek J. (Nat. Genet. 2002)
    1016. Disruption of the ATM gene in breast cancer. (PubMed id 11376801)9 Lu Y....Shipley J. (Cancer Genet. Cytogenet. 2001)
    1017. p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. (PubMed id 11468183)9 Pettitt A.R....Stankovic T. (Blood 2001)
    1018. Investigation on the role of the ATM gene in chronic myeloid leukaemia. (PubMed id 11516106)9 Melo J.V....Yuille M.R. (Leukemia 2001)
    1019. Chromosomal breakage syndromes and the BRCA1 genome surveillance complex. (PubMed id 11733219)9 Futaki M. and Liu J.M. (Trends Mol Med 2001)
    1020. [Influence of abnormalities of TP53 and ATM genes for course of B-cell chronic lymphocytic leukemia]. (PubMed id 11875779)9 Rupniewska Z.M. and Wasik-Szczepanek E. (Postepy Hig Med Dosw 2001)
    1021. Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast. (PubMed id 11553781)9 Lopez-Girona A....Russell P. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    1022. Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein. (PubMed id 11466608)9 Keating K.E....Lavin M.F. (Oncogene 2001)
    1023. ATM status confers sensitivity to arsenic cytotoxic effects. (PubMed id 11507245)9 MenAcndez D....Ostrosky-Wegman P. (Mutagenesis 2001)
    1024. Futile caspase-8 activation during the apoptotic cell death induced by DNA damaging agents in human B-lymphoblasts. (PubMed id 11525634)9 Vit J.P....Rosselli F. (Exp. Cell Res. 2001)
    1025. Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. (PubMed id 11025670)9 Melchionna R....McGowan C.H. (Nat. Cell Biol. 2000)
    1026. A polymorphism in the ATM gene modulates the penetrance of hereditary non-polyposis colorectal cancer. (PubMed id 11093816)9 Maillet P....Sappino A.P. (Int. J. Cancer 2000)
    1027. Increased risk of breast cancer following irradiation for Hodgkin's disease is not a result of ATM germline mutations. (PubMed id 10866292)9 Broeks A....van T Veer L.J. (Int. J. Radiat. Biol. 2000)
    1028. Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis. (PubMed id 10919664)9 Shen C.Y....Wu C.W. (Cancer Res. 2000)
    1029. Chromosomal breakage syndromes. (PubMed id 10448147)9 Carney J.P. (Curr. Opin. Immunol. 1999)
    1030. Splicing defects in the ataxia-telangiectasia gene, ATM: underlying mutations and consequences. (PubMed id 10330348)9 Teraoka S.N....Concannon P. (Am. J. Hum. Genet. 1999)
    1031. NS22: a highly polymorphic complex microsatellite marker within the ATM gene. (PubMed id 10051159)9 Udar N....Gatti R.A. (Am. J. Med. Genet. 1999)
    1032. ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK. (PubMed id 10597277)9 Hall-Jackson C.A.... Smythe C. (Oncogene 1999)
    1033. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. (PubMed id 10454554)9 Ritchie K.B....Petes T.D. (Mol. Cell. Biol. 1999)
    1034. The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia. (PubMed id 9827931)9 Takeuchi S....Koeffler H.P. (Br. J. Haematol. 1998)
    1035. Heterozygosity for mutations in the ataxia telangiectasia gene is not a major cause of radiotherapy complications in breast cancer patients. (PubMed id 9764584)9 Shayeghi M....Yarnold J. (Br. J. Cancer 1998)
    1036. Ataxia-telangiectasia, ATM and genomic stability: maintaining a delicate balance. Two international workshops on ataxia-telangiectasia, related disorders and the ATM protein. (PubMed id 9823376)9 Shiloh Y. (Biochim. Biophys. Acta 1998)
    1037. Defective control of apoptosis, radiosensitivity, and spindle checkpoint in ataxia telangiectasia. (PubMed id 9810001)9 Takagi M....Mizutani S. (Cancer Res. 1998)
    1038. Testing for mutations of the ataxia telangiectasia gene in radiosensitive breast cancer patients. (PubMed id 9683358)9 Ramsay J....Lavin M. (Radiother Oncol 1998)
    1039. Requirements for p53 and the ATM gene product in the regulation of G1/S and S phase checkpoints. (PubMed id 9488036)9 Xie G....D'Anna J.A. (Oncogene 1998)
    1040. Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia. (PubMed id 9697112)9 Soares H.D....McKinnon P.J. (Neuroscience 1998)
    1041. A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation. (PubMed id 9808536)9 Hosoi Y....Ono T. (Int. J. Cancer 1998)
    1042. Loss of heterozygosity at 11q23.1 in breast carcinomas: indication for involvement of a gene distal and close to ATM. (PubMed id 9071570)9 Laake K....rresen-Dale A.L. (amp 1997)
    1043. Critical telomere shortening regulated by the ataxia-telangiectasia gene acts as a DNA damage signal leading to activation of p53 protein and limited life-span of human diploid fibroblasts. A review. (PubMed id 9467855)9 Vaziri H. (Biochemistry Mosc. 1997)
    1044. Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. (PubMed id 9382850)9 Flaggs G....Carr A.M. (Curr. Biol. 1997)
    1045. A frequent polymorphism of the gene mutated in ataxia telangiectasia. (PubMed id 9076718)9 DAPrk T....Stuhrmann M. (Mol. Cell. Probes 1997)
    1046. Fragments of ATM which have dominant-negative or complementing activity. (PubMed id 9121450)9 Morgan S.E....Kastan M.B. (Mol. Cell. Biol. 1997)
    1047. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. (PubMed id 8553072)9 Sanchez Y....Elledge S.J. (Science 1996)
    1048. Rapamycin resistance in ataxia-telangiectasia. (PubMed id 8806686)9 Beamish H....Lavin M. (Oncogene 1996)
    1049. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. (PubMed id 8843194)9 Xu Y....Baltimore D. (amp 1996)
    1050. Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene. (PubMed id 8661102)9 Pecker I....Ziv Y. (Genomics 1996)
    1051. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. (PubMed id 7545545)9 Morrow D.M....Hieter P. (Cell 1995)
    1052. Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. (PubMed id 8533157)9 Enoch T. and Norbury C. (Trends Biochem. Sci. 1995)
    1053. Flow cytometric measurement of proliferating cell nuclear antigen (PCNA) in solid tumors. (PubMed id 8165522)9 Wenz F....Flentje M. (Strahlenther Onkol 1994)
    1054. Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation. (PubMed id 7836856)9 Murnane J.P....Christman M.F. (Int. J. Radiat. Biol. 1994)
    1055. Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage. (PubMed id 20111719)9 Guerra L....Frisan T. (PLoS ONE 2010)
    1056. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. (PubMed id 20194434)9 Wilhelm M.T....Mak T.W. (amp 2010)
    1057. Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase. (PubMed id 20160494)9 McNeely S....Tse A. (Cell Cycle 2010)
    1058. DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. (PubMed id 20205745)9 An J....Zhou P.K. (BMC Mol. Biol. 2010)
    1059. Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. (PubMed id 20060491)9 Costes S.V....Jakob B. (Mutat. Res. 2010)
    1060. Low energy proton beam induces efficient cell killing in A549 lung adenocarcinoma cells. (PubMed id 20210520)9 Ghosh S....Krishna M. (Cancer Invest. 2010)
    1061. A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. (PubMed id 20089117)9 Kovalenko O.A....Santos J.H. (Aging Cell 2010)
    1062. Multiplex ligation-dependent probe amplification versus multiprobe fluorescence in situ hybridization to detect genomic aberrations in chronic lymphocytic leukemia: a tertiary center experience. (PubMed id 20093390)9 Al Zaabi E.A....Greer W.L. (J Mol Diagn 2010)
    1063. Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation. (PubMed id 19643530)9 Moon D.O....Kim G.Y. (Cancer Lett. 2010)
    1064. Chk2 down-regulation by promoter hypermethylation in human bulk gliomas. (PubMed id 19969004)9 Wang H....Wang H. (Life Sci. 2010)
    1065. Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells. (PubMed id 19923412)9 Bork U....ThAcvenod F. (Am. J. Physiol. Renal Physiol. 2010)
    1066. Lack of effect of RuvB-like proteins on DNA damage signaling activation. (PubMed id 20355335)9 Gospodinov A. and Anachkova B. (Z. Naturforsch., C, J. Biosci. 2010)
    1067. Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response. (PubMed id 19676051)9 Zuco V....Zunino F. (Int. J. Cancer 2010)
    1068. WIP1 phosphatase at the crossroads of cancer and aging. (PubMed id 19879149)9 Le Guezennec X. and Bulavin D.V. (Trends Biochem. Sci. 2010)
    1069. Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication. (PubMed id 20014310)9 Zhao H....Darzynkiewicz Z. (Cytometry A 2010)
    1070. Profiling of cell cycle genes of breast cells exposed to etodolac. (PubMed id 20372855)9 Roy D....Calaf G.M. (Oncol. Rep. 2010)
    1071. miR-181a and miR-630 regulate cisplatin-induced cancer cell death. (PubMed id 20145152)9 Galluzzi L....Kroemer G. (Cancer Res. 2010)
    1072. Germline mutations and polymorphisms in the origins of cancers in women. (PubMed id 20111735)9 Hirshfield K.M....Levine A.J. (J Oncol 2010)
    1073. Inter-individual variation in DNA double-strand break repair in human fibroblasts before and after exposure to low doses of ionizing radiation. (PubMed id 19896956)9 Wilson P.F....Thompson L.H. (Mutat. Res. 2010)
    1074. [Chromosome study on chronic lymphocytic leukemia using CpG-oligodeoxynucleotide as immunostimulant agent]. (PubMed id 20140876)9 Wu Y....Bai S. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2010)
    1075. 53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope. (PubMed id 19876065)9 Perfettini J.L....Kroemer G. (Cell Death Differ. 2010)
    1076. Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain. (PubMed id 19414482)9 Iourov I.Y....Yurov Y.B. (Hum. Mol. Genet. 2009)
    1077. Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E. (PubMed id 19423708)9 Wang H....Legerski R.J. (J. Biol. Chem. 2009)
    1078. [Cellular repair potential in families of ataxia-telangiectasia patients]. (PubMed id 20141033)9 Polubotko E.A....Spivak I.M. (Tsitologiia 2009)
    1079. The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status. (PubMed id 19674456)9 Turinetto V....Giachino C. (BMC Cancer 2009)
    1080. Curcumin-induced DNA damage and inhibited DNA repair genes expressions in mouse-rat hybrid retina ganglion cells (N18). (PubMed id 19263217)9 Lu H.F....Chung J.G. (Neurochem. Res. 2009)
    1081. Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage. (PubMed id 19906512)9 Lee M.S....Gilchrest B.A. (J. Dermatol. Sci. 2009)
    1082. Cytometric assessment of DNA damage induced by DNA topoisomerase inhibitors. (PubMed id 19763948)9 Darzynkiewicz Z....Tanaka T. (Methods Mol. Biol. 2009)
    1083. DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide. (PubMed id 19111594)9 Jowsey P.A....Blain P.G. (Toxicology 2009)
    1084. Proteasome regulation of ULBP1 transcription. (PubMed id 19414815)9 Butler J.E....Lutz C.T. (J. Immunol. 2009)
    1085. A novel type of p53 pathway dysfunction in chronic lymphocytic leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene. (PubMed id 19491257)9 Johnson G.G....Pettitt A.R. (Cancer Res. 2009)
    1086. [Syndrome of premature ageing in ataxia-telangiectasia patients]. (PubMed id 19799357)9 Polubot'ko E.A....Spivak I.M. (Tsitologiia 2009)
    1087. Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response. (PubMed id 19616017)9 Brozovic A....Fritz G. (Mutat. Res. 2009)
    1088. Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. (PubMed id 19303015)9 Oakley F....Mann D.A. (Gastroenterology 2009)
    1089. Ascochlorin activates p53 in a manner distinct from DNA damaging agents. (PubMed id 19253369)9 Jeong J.H....Chang Y.C. (Int. J. Cancer 2009)
    1090. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. (PubMed id 19261750)9 Cui B....Friedman H.S. (Mol. Pharmacol. 2009)
    1091. DNA damage response as a biomarker in treatment of leukemias. (PubMed id 19411853)9 Halicka H.D....Darzynkiewicz Z. (Cell Cycle 2009)
    1092. Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies. (PubMed id 19661131)9 JardAc T....Vasson M.P. (Endocr. Relat. Cancer 2009)
    1093. RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1. (PubMed id 19228710)9 Watanabe K....Tateishi S. (Nucleic Acids Res. 2009)
    1094. Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation. (PubMed id 19038232)9 SA!nchez Y....Aller P. (Biochem. Pharmacol. 2009)
    1095. Coactivation of ATM/ERK/NF-kappaB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes. (PubMed id 19324081)9 Ahmed K.M....Li J.J. (amp 2009)
    1096. Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition. (PubMed id 19167809)9 Park I....Chung W.Y. (Cancer Lett. 2009)
    1097. DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair. (PubMed id 19398584)9 Huda N....Gilley D. (Mol. Cell. Biol. 2009)
    1098. Chk1 phosphorylation during mitosis: a new role for a master regulator. (PubMed id 19282670)9 Wilsker D. and Bunz F. (Cell Cycle 2009)
    1099. Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. (PubMed id 19067706)9 Nieto-RementerA-a N....Asumendi A. (Br. J. Dermatol. 2009)
    1100. TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: implications for a replication restart-based mechanism for ATR checkpoint activation. (PubMed id 19652550)9 Yan S. and Michael W.M. (Cell Cycle 2009)
    1101. High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors. (PubMed id 19951990)9 Beyrouthy M.J....Spinella M.J. (Cancer Res. 2009)
    1102. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. (PubMed id 19151707)9 Tian B....Mao Z. (Nat. Cell Biol. 2009)
    1103. The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases. (PubMed id 19448405)9 Solier S. and Pommier Y. (Cell Cycle 2009)
    1104. Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts. (PubMed id 19283680)9 Mishra P.K....Maudar K.K. (Genet. Mol. Res. 2009)
    1105. Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy. (PubMed id 19278963)9 Nowak D....Koeffler H.P. (Haematologica 2009)
    1106. Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. (PubMed id 19409520)9 Waltes R....Doerk T. (Am. J. Hum. Genet. 2009)
    1107. No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells. (PubMed id 19071232)9 Erdmann N. and Harrington L.A. (DNA Repair (Amst.) 2009)
    1108. Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China. (PubMed id 18570662)9 Fang W....Yao K. (J Transl Med 2008)
    1109. Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia. (PubMed id 18073348)9 Le Toriellec E....Stern M.H. (Blood 2008)
    1110. Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study. (PubMed id 18608517)9 Sasaki M....Nakanuma Y. (Free Radic. Res. 2008)
    1111. AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition. (PubMed id 18413665)9 Caporali S....D'Atri S. (Mol. Pharmacol. 2008)
    1112. A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasia. (PubMed id 18431795)9 Porcedda P....Giachino C. (Cytometry A 2008)
    1113. [Radiation-induced sequelae: toward an individual profile]. (PubMed id 18757226)9 Azria D....Ozsahin M. (Cancer Radiother 2008)
    1114. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. (PubMed id 18794134)9 Rainey M.D....Kastan M.B. (Cancer Res. 2008)
    1115. Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions. (PubMed id 18948271)9 Li J....Smerdon S.J. (J. Biol. Chem. 2008)
    1116. Structure and function of MYST1 histone acetyltransferase in the interactome of animal cells. (PubMed id 18774930)9 Dmitriev R.I....Pestov N.B. (Biochemistry Mosc. 2008)
    1117. A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL. (PubMed id 18200038)9 Best O.G....Oscier D.G. (Leukemia 2008)
    1118. Mdm2 promotes genetic instability and transformation independent of p53. (PubMed id 18541670)9 Bouska A....Eischen C.M. (Mol. Cell. Biol. 2008)
    1119. Is defect in phosphorylation of Nbs1 responsible for high radiosensitivity of T-lymphocyte leukemia cells MOLT-4? (PubMed id 18262646)9 RezA!covA! M....LukA!sovA! E. (Leuk. Res. 2008)
    1120. Early events in the mammalian response to DNA double-strand breaks. (PubMed id 18644834)9 Riches L.C....Gooderham N.J. (Mutagenesis 2008)
    1121. Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. (PubMed id 18053307)9 Renis M....Galvano F. (Br. J. Nutr. 2008)
    1122. Differential signaling pathways in angiotensin II- and epidermal growth factor-stimulated hepatic C9 cells. (PubMed id 18687808)9 Yin X....Catt K.J. (Mol. Pharmacol. 2008)
    1123. Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair. (PubMed id 18211700)9 Smith J.A....Daniel R. (Virol. J. 2008)
    1124. Cellular DNA repair cofactors affecting hepatitis B virus infection and replication. (PubMed id 18763290)9 Zhao F....Zhong H. (World J. Gastroenterol. 2008)
    1125. Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation. (PubMed id 18519763)9 Suehiro Y....Hinoda Y. (Clin. Cancer Res. 2008)
    1126. Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint. (PubMed id 18483255)9 Huang H....Muschel R.J. (Cancer Res. 2008)
    1127. Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. (PubMed id 18644861)9 Lovly C.M.... Piwnica-Worms H. (Mol. Cell. Biol. 2008)
    1128. Radiosensitization of cervical cancer cells via double-strand DNA break repair inhibition. (PubMed id 18589211)9 Fuhrman C.B....Zempolich K.A. (Gynecol. Oncol. 2008)
    1129. Different clinical and immunological presentation of ataxia-telangiectasia within the same family. (PubMed id 18504682)9 Soresina A....Plebani A. (Neuropediatrics 2008)
    1130. Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1. (PubMed id 18804090)9 Iwabuchi K....Date T. (Biochem. Biophys. Res. Commun. 2008)
    1131. DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. (PubMed id 17991895)9 Palii S.S....Robertson K.D. (Mol. Cell. Biol. 2008)
    1132. Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemia. (PubMed id 18246537)9 Lehmann S....Koeffler H.P. (Cancer 2008)
    1133. Induction of persistent double strand breaks following multiphoton irradiation of cycling and G1-arrested mammalian cells-replication-induced double strand breaks. (PubMed id 18557822)9 Harper J.V....O'Neill P. (Photochem. Photobiol. 2008)
    1134. Direct determination of intracellular daunorubicin in intact confluent monolayers of AT1 prostate carcinoma cells using a multiwell-multilabel counter. (PubMed id 18634747)9 Sauvant C....Gekle M. (Anal. Biochem. 2008)
    1135. [Genetic predeterminations of head and neck cancer]. (PubMed id 18833034)9 Rusin P....Majsterek I. (Postepy Hig Med Dosw (Online) 2008)
    1136. [Determinants and predictive factors of tumour radiosensitivity]. (PubMed id 18187356)9 Hennequin C....Favaudon V. (Cancer Radiother 2008)
    1137. Combined molecular biological and molecular cytogenetic analysis of genomic changes in 146 patients with B-cell chronic lymphocytic leukemia. (PubMed id 18665750)9 Berkova A....Michalova K. (Neoplasma 2008)
    1138. p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. (PubMed id 18392133)9 Li Q....Mattingly R.R. (Neoplasia 2008)
    1139. How ATR turns on: TopBP1 goes on ATRIP with ATR. (PubMed id 18519633)9 Burrows A.E. and Elledge S.J. (amp 2008)
    1140. Hereditary breast cancer: from molecular pathology to tailored therapies. (PubMed id 18682420)9 Tan D.S....Reis-Filho J.S. (J. Clin. Pathol. 2008)
    1141. c-MYC protein is degraded in response to UV irradiation. (PubMed id 18196973)9 Britton S....Calsou P. (Cell Cycle 2008)
    1142. Haplotype patterns in cancer-related genes with long-range linkage disequilibrium: no evidence of association with breast cancer or positive selection. (PubMed id 18000525)9 Ribas G....BenA-tez J. (Eur. J. Hum. Genet. 2008)
    1143. AsSIRTing the DNA damage response. (PubMed id 18215521)9 Gorospe M. and de Cabo R. (Trends Cell Biol. 2008)
    1144. Modulation of cellular response to anticancer treatment by caffeine: inhibition of cell cycle checkpoints, DNA repair and more. (PubMed id 18691092)9 Sabisz M. and Skladanowski A. (Curr Pharm Biotechnol 2008)
    1145. Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine. (PubMed id 18791269)9 Thangasamy T....Burd R. (Cell. Oncol. 2008)
    1146. Inhibition of S-phase progression triggered by UVA-induced ROS does not require a functional DNA damage checkpoint response in mammalian cells. (PubMed id 18603484)9 Girard P.M....Sage E. (DNA Repair (Amst.) 2008)
    1147. Mechanism and regulation of class switch recombination. (PubMed id 18370922)9 Stavnezer J....Schrader C.E. (Annu. Rev. Immunol. 2008)
    1148. Premature senescence of balding dermal papilla cells in vitro is associated with p16(INK4a) expression. (PubMed id 17989730)9 Bahta A.W....Philpott M.P. (J. Invest. Dermatol. 2008)
    1149. DNA damage response in prostate cancer cells after high-intensity focused ultrasound (HIFU) treatment. (PubMed id 18507002)9 Ide H....Horie S. (Anticancer Res. 2008)
    1150. Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. (PubMed id 18471974)9 Batchelor E....Lahav G. (Mol. Cell 2008)
    1151. Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks. (PubMed id 18602349)9 BaA+uelos C.A....Olive P.L. (DNA Repair (Amst.) 2008)
    1152. Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase. (PubMed id 18459160)9 Zhao H....Darzynkiewicz Z. (Cytometry A 2008)
    1153. RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205. (PubMed id 18519686)9 Yan J.... Jetten A.M. (Cancer Res. 2008)
    1154. Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites. (PubMed id 18619531)9 Iwahori S.... Tsurumi T. (Cell. Signal. 2008)
    1155. Comparison of ataxia-telangiectasia mutated protein expression in diffuse large B-cell lymphomas of primary central nervous system and non-central nervous system origin. (PubMed id 17516749)9 Kim S.H....Yang W.I. (amp 2007)
    1156. The ATR pathway: fine-tuning the fork. (PubMed id 17531546)9 Paulsen R.D. and Cimprich K.A. (DNA Repair (Amst.) 2007)
    1157. ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. (PubMed id 17560543)9 Bai L. and Merchant J.L. (Biochem. Biophys. Res. Commun. 2007)
    1158. Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. (PubMed id 17517611)9 O'Neill B.M....Romesberg F.E. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    1159. Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay. (PubMed id 17229728)9 Morita T....Ohno S. (J. Biol. Chem. 2007)
    1160. The anti-apoptotic factor Che-1/AATF links transcriptional regulation, cell cycle control, and DNA damage response. (PubMed id 17634135)9 Passananti C. and Fanciulli M. (Cell Div 2007)
    1161. The role of the DNA damage checkpoint pathway in intraductal papillary mucinous neoplasms of the pancreas. (PubMed id 17671118)9 Miyasaka Y....Tsuneyoshi M. (Clin. Cancer Res. 2007)
    1162. DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy. (PubMed id 17573848)9 Bartkova J....Bartek J. (Int. J. Androl. 2007)
    1163. G alpha 12/13 basally regulates p53 through Mdm4 expression. (PubMed id 17510313)9 Kim M.S....Kim S.G. (Mol. Cancer Res. 2007)
    1164. DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication. (PubMed id 17280685)9 Shimura T....Aladjem M.I. (J. Mol. Biol. 2007)
    1165. Proteasome function is required for DNA damage response and fanconi anemia pathway activation. (PubMed id 17671210)9 Jacquemont C. and Taniguchi T. (Cancer Res. 2007)
    1166. Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones. (PubMed id 17483520)9 Biard D.S. (Nucleic Acids Res. 2007)
    1167. Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. (PubMed id 17378912)9 Leung W.K....Sung J.J. (Am. J. Gastroenterol. 2007)
    1168. Ten genes for inherited breast cancer. (PubMed id 17292821)9 Walsh T. and King M.C. (Cancer Cell 2007)
    1169. Che-1: a new effector of checkpoints signaling. (PubMed id 17377493)9 Floridi A. and Fanciulli M. (Cell Cycle 2007)
    1170. Identification of women with an increased risk of developing radiation-induced breast cancer. (PubMed id 17617928)9 Cardis E....Tavtigian S.V. (Breast Cancer Res. 2007)
    1171. Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer. (PubMed id 17337132)9 SAPderlund K....Askmalm M.S. (Int. J. Radiat. Oncol. Biol. Phys. 2007)
    1172. Enhanced radiation-induced cytotoxic effect by 2-ME in glioma cells is mediated by induction of cell cycle arrest and DNA damage via activation of ATM pathways. (PubMed id 17980860)9 Zou H....Wang L. (Brain Res. 2007)
    1173. p53-Dependent but ATM-independent inhibition of DNA synthesis and G2 arrest in cadmium-treated human fibroblasts. (PubMed id 17174997)9 Cao F....Kaufmann W. (Toxicol. Appl. Pharmacol. 2007)
    1174. Ataxia telangiectasia-mutated gene is a possible biomarker for discrimination of infiltrative deep penetrating nevi and metastatic vertical growth phase melanoma. (PubMed id 18006941)9 Roesch A....Vogt T. (amp 2007)
    1175. Centrosomal localization of DNA damage checkpoint proteins. (PubMed id 17171639)9 Zhang S....Grosse F. (J. Cell. Biochem. 2007)
    1176. Functional link between DNA damage responses and transcriptional regulation by ATM in response to a histone deacetylase inhibitor TSA. (PubMed id 19746225)9 Lee J.S. (Cancer Res Treat 2007)
    1177. Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis. (PubMed id 17979659)9 Camins A....PallA s M. (Curr. Drug Metab. 2007)
    1178. Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability. (PubMed id 17277230)9 Li J....Pang Q. (Carcinogenesis 2007)
    1179. Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice. (PubMed id 17182831)9 Reliene R. and Schiestl R.H. (J. Nutr. 2007)
    1180. In vitro expression levels of cell-cycle checkpoint proteins are associated with cellular DNA repair capacity in peripheral blood lymphocytes: a multivariate analysis. (PubMed id 17362036)9 Fan Y.H....Wei Q. (J. Proteome Res. 2007)
    1181. A genetically determined dose-volume histogram predicts for rectal bleeding among patients treated with prostate brachytherapy. (PubMed id 17490827)9 Cesaretti J.A....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2007)
    1182. Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia. (PubMed id 17933474)9 Rogatcheva M.B....Schook L.B. (Gene 2007)
    1183. DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'. (PubMed id 17700066)9 Bartek J....Bartkova J. (Cell Cycle 2007)
    1184. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. (PubMed id 17575048)9 Delacroix S....Karnitz L.M. (amp 2007)
    1185. Involvement of homologous recombination in carcinogenesis. (PubMed id 17452246)9 Reliene R....Schiestl R.H. (Adv. Genet. 2007)
    1186. Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase. (PubMed id 17297310)9 Tanaka T....Darzynkiewicz Z. (Cell Cycle 2007)
    1187. Cigarette smoke induces cellular senescence. (PubMed id 16840774)9 Nyunoya T....Hunninghake G.W. (Am. J. Respir. Cell Mol. Biol. 2006)
    1188. Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation. (PubMed id 16879433)9 Grenon M....Jackson S.P. (FEMS Yeast Res. 2006)
    1189. MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. (PubMed id 17158742)9 Dimitrova N. and de Lange T. (amp 2006)
    1190. [Autosomal recessive cerebellar ataxias with oculomotor apraxia]. (PubMed id 16518257)9 Le Ber I....DA1rr A. (Rev. Neurol. (Paris) 2006)
    1191. [Ataxia-telangiectasia: a review]. (PubMed id 16423518)9 Bott L....Sardet A. (Arch Pediatr 2006)
    1192. Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression. (PubMed id 17023046)9 Bolufer P....Sanz M.A. (Leuk. Res. 2006)
    1193. BLM is an early responder to DNA double-strand breaks. (PubMed id 16876111)9 Karmakar P....Enomoto T. (Biochem. Biophys. Res. Commun. 2006)
    1194. New translocations in a case of atypical B-cell chronic lymphocytic leukemia: involvement of ATM, MLL, and TP53 genes. (PubMed id 16938579)9 Collado R....Carbonell F. (Cancer Genet. Cytogenet. 2006)
    1195. Imperfect correlation between p53 dysfunction and deletion of TP53 and ATM in chronic lymphocytic leukaemia. (PubMed id 16437137)9 Carter A....Pettitt A.R. (Leukemia 2006)
    1196. Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue. (PubMed id 16314843)9 Rashi-Elkeles S....Shiloh Y. (Oncogene 2006)
    1197. Impaired interferon-gamma production in response to live bacteria and Toll-like receptor agonists in patients with ataxia telangiectasia. (PubMed id 17100756)9 Reichenbach J....Zielen S. (Clin. Exp. Immunol. 2006)
    1198. Modifications of nuclear architecture and chromatin organization in ataxia telangiectasia cells are coupled to changes of gene transcription. (PubMed id 16795050)9 Grattarola M....Vergani L. (J. Cell. Biochem. 2006)
    1199. Peripheral blood complete remission after splenic irradiation in mantle-cell lymphoma with 11q22-23 deletion and ATM inactivation. (PubMed id 16956411)9 Filippi A.R....Ricardi U. (Radiat Oncol 2006)
    1200. ATM promoter analysis in childhood lymphoid malignancies: a brief communication. (PubMed id 16125772)9 Gumy-Pause F....Sappino A.P. (Leuk. Res. 2006)
    1201. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. (PubMed id 16427010)9 Franco S....Alt F.W. (Mol. Cell 2006)
    1202. DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. (PubMed id 16449651)9 Liu G. and Chen X. (Mol. Cell. Biol. 2006)
    1203. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. (PubMed id 16622404)9 DuprAc A....Gautier J. (amp 2006)
    1204. Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk. (PubMed id 16777992)9 Kaufmann W.K....Carey L.A. (Carcinogenesis 2006)
    1205. CYP1A1 activation of aminoflavone leads to DNA damage in human tumor cell lines. (PubMed id 16096788)9 Pobst L.J. and Ames M.M. (Cancer Chemother. Pharmacol. 2006)
    1206. Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. (PubMed id 16360315)9 Smits V.A....Jackson S.P. (Curr. Biol. 2006)
    1207. Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation. (PubMed id 16186801)9 Pickering M.T. and Kowalik T.F. (Oncogene 2006)
    1208. Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors. (PubMed id 16400190)9 Lu S....Wang Y.A. (Carcinogenesis 2006)
    1209. TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons. (PubMed id 16539655)9 Zhang P....Mattson M.P. (J. Neurochem. 2006)
    1210. Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. (PubMed id 16520385)9 Kruhlak M.J....Nussenzweig A. (J. Cell Biol. 2006)
    1211. Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation. (PubMed id 16390936)9 Pan-HammarstrAPm Q....HammarstrAPm L. (J. Exp. Med. 2006)
    1212. S-Adenosylmethionine decarboxylase partially regulates cell growth of HL-60 cells by controlling the intracellular ROS level: Early senescence and sensitization to gamma-radiation. (PubMed id 17069747)9 Kim J.S....Kim I.G. (Arch. Biochem. Biophys. 2006)
    1213. 11q22.3 deletion in B-chronic lymphocytic leukemia is specifically associated with bulky lymphadenopathy and ZAP-70 expression but not reduced expression of adhesion/cell surface receptor molecules. (PubMed id 16321852)9 Dickinson J.D....Joshi S.S. (amp 2006)
    1214. Protein kinases that regulate chromosome stability and their downstream targets. (PubMed id 18724058)9 Nojima H. (Genome Dyn 2006)
    1215. Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine. (PubMed id 16760673)9 Huang X....Darzynkiewicz Z. (amp 2006)
    1216. Tying the loose ends together in DNA double strand break repair with 53BP1. (PubMed id 16945145)9 Adams M.M. and Carpenter P.B. (Cell Div 2006)
    1217. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. (PubMed id 16618811)9 Bekker-Jensen S....Lukas J. (J. Cell Biol. 2006)
    1218. Nijmegen breakage syndrome (NBS) with neurological abnormalities and without chromosomal instability. (PubMed id 16033915)9 SeemanovA! E....Digweed M. (J. Med. Genet. 2006)
    1219. DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. (PubMed id 16436515)9 Moiseeva O....Ferbeyre G. (Mol. Biol. Cell 2006)
    1220. Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair. (PubMed id 16818713)9 Toulany M....Rodemann H.P. (Clin. Cancer Res. 2006)
    1221. Genetic abnormalities and clinical outcome in chronic lymphocytic leukemia. (PubMed id 17074592)9 RipollAcs L....CaballA-n M.R. (Cancer Genet. Cytogenet. 2006)
    1222. Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells. (PubMed id 17172433)9 Agarwal C....Agarwal R. (Mol. Cancer Ther. 2006)
    1223. DNA damage checkpoints in mammals. (PubMed id 16314342)9 Niida H. and Nakanishi M. (Mutagenesis 2006)
    1224. The sensitivity of human mesenchymal stem cells to ionizing radiation. (PubMed id 16839703)9 Chen M.F....Lee K.D. (Int. J. Radiat. Oncol. Biol. Phys. 2006)
    1225. BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation. (PubMed id 16707425)9 Chen X.... Godwin A.K. (Cancer Res. 2006)
    1226. Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: involvement of reactive oxygen species. (PubMed id 16861926)9 Tanaka T....Darzynkiewicz Z. (Cell Cycle 2006)
    1227. Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. (PubMed id 15705874)9 Maude S.L. and Enders G.H. (Cancer Res. 2005)
    1228. Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells. (PubMed id 15867362)9 Pan J....Yeung S.C. (Cancer Res. 2005)
    1229. Roles of nibrin and AtM/ATR kinases on the G2 checkpoint under endogenous or radio-induced DNA damage. (PubMed id 16238096)9 Marcelain K....Pincheira J. (Biol. Res. 2005)
    1230. ATM haplotypes and associated mutations in Iranian patients with ataxia-telangiectasia: recurring homozygosity without a founder haplotype. (PubMed id 15843990)9 Babaei M....Gatti R.A. (Hum. Genet. 2005)
    1231. DNA-PK is responsible for enhanced phosphorylation of histone H2AX under hypertonic conditions. (PubMed id 16046194)9 Reitsema T.... Olive P.L. (DNA Repair 2005)
    1232. Richter's syndrome: biology and therapy. (PubMed id 16053658)9 Yee K.W....Giles F.J. (Cancer J 2005)
    1233. ATM signaling and genomic stability in response to DNA damage. (PubMed id 15603757)9 Lavin M.F....Gueven N. (Mutat. Res. 2005)
    1234. Ataxia-telangiectasia genes and breast cancer risk in a French family study. (PubMed id 16180724)9 Andrieu N....Stoppa-Lyonnet D. (J. Dairy Res. 2005)
    1235. Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D. (PubMed id 15970689)9 Lu X....Donehower L.A. (Cell Cycle 2005)
    1236. The ATM-dependent DNA damage signaling pathway. (PubMed id 16869743)9 Kitagawa R. and Kastan M.B. (Cold Spring Harb. Symp. Quant. Biol. 2005)
    1237. Molecular basis of ataxia telangiectasia and related diseases. (PubMed id 16038621)9 Ball L.G. and Xiao W. (Acta Pharmacol. Sin. 2005)
    1238. Understanding breast cancer risk -- where do we stand in 2005? (PubMed id 15784178)9 Dumitrescu R.G. and Cotarla I. (J. Cell. Mol. Med. 2005)
    1239. Harmonising the response to DSBs: a new string in the ATM bow. (PubMed id 15978533)9 LAPbrich M. and Jeggo P.A. (DNA Repair (Amst.) 2005)
    1240. Breast cancer and ovarian cancer genetics. (PubMed id 16218901)9 Edlich R.F....Lin K.Y. (J Long Term Eff Med Implants 2005)
    1241. DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. (PubMed id 15709017)9 Ariumi Y....Trono D. (J. Virol. 2005)
    1242. Association of common ATM polymorphism with bilateral breast cancer. (PubMed id 15756685)9 Heikkinen K....Winqvist R. (Int. J. Cancer 2005)
    1243. Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors. (PubMed id 16234517)9 Honrado E....BenA-tez J. (J. Clin. Oncol. 2005)
    1244. Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia. (PubMed id 16150740)9 Ziv S....Barzilai A. (Hum. Mol. Genet. 2005)
    1245. Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development. (PubMed id 15705620)9 Wells D....Cohen J. (Hum. Reprod. 2005)
    1246. Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis. (PubMed id 16098182)9 Huang X....Darzynkiewicz Z. (Cell Prolif. 2005)
    1247. Artemis links ATM to double strand break rejoining. (PubMed id 15684609)9 Jeggo P.A. and LAPbrich M. (Cell Cycle 2005)
    1248. [ATM gene mutations in Chinese patients with ataxia telangiectasia]. (PubMed id 15793768)9 Jiang H....Shen L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    1249. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. (PubMed id 16221682)9 Hresko R.C. and Mueckler M. (J. Biol. Chem. 2005)
    1250. [Research on clinical characteristics and ATM gene mutations in Chinese patients with ataxia-telangiectasia]. (PubMed id 16029571)9 Jiang H....Tang J.G. (Zhonghua Yi Xue Za Zhi 2005)
    1251. Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes. (PubMed id 16091150)9 Allen-Brady K. and Camp N.J. (BMC Cancer 2005)
    1252. Insights into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin's and non-Hodgkin's lymphomas. (PubMed id 15973455)9 Schmitz R....KA1ppers R. (Leukemia 2005)
    1253. Chronic lymphocytic leukemia: novel prognostic factors and their relevance fo