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ATM Gene

protein-coding   GIFtS: 77
GCID: GC11P108093

Ataxia Telangiectasia Mutated

(Previous names: ataxia telangiectasia mutated (includes complementation...)
(Previous symbols: ATA, ATDC, ATC, ATD)
  See ATM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ataxia Telangiectasia Mutated1 2 3     Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C And D)1
ATA1 2 5     Homolog (S. Cerevisiae)1
ATC1 2     Telomere Maintenance 11
ATD1 2     ATE2
ATDC1 2     TELO12
TEL11 2     AT Mutated2
A-T Mutated2 3     Serine-Protein Kinase ATM2
EC 2.7.11.13 8     TEL1, Telomere Maintenance 1, Homolog2
AT12 5     

External Ids:    HGNC: 7951   Entrez Gene: 4722   Ensembl: ENSG000001493117   OMIM: 6075855   UniProtKB: Q133153   

Export aliases for ATM gene to outside databases

Previous GC identifers: GC11P110302 GC11P109450 GC11P108127 GC11P107631 GC11P107599 GC11P104019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATM Gene:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle
checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream
proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17
and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master
controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for
genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive
disorder. (provided by RefSeq, Aug 2010)

GeneCards Summary for ATM Gene:
ATM (ataxia telangiectasia mutated) is a protein-coding gene. Diseases associated with ATM include b-cell chronic lymphocytic leukemia, and chromosome 11q deletion. GO annotations related to this gene include protein serine/threonine kinase activity and protein complex binding.

UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
Function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),
apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage
sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant
H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in
pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to
enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual
B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by
mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to
the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle
control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2,
CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle
and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role
in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in
response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation.
Phosphorylates ATF2 which stimulates its function in DNA damage response

summary for ATM Gene:
ATM (Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related) are closely related
kinases that are activated by DNA damage. These serine-threonine protein kinases are part of the
phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding
proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by
phosphorylating a number of key proteins. Once activated, the checkpoint leads to cell cycle arrest and
either DNA repair or apoptosis. ATM is activated by double stranded breaks and phosphorylates Chk2, whilst
ATR is activated by single strand breaks and phosphorylates Chk1.

Gene Wiki entry for ATM (Ataxia telangiectasia mutated) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATM gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ATM promoter sequence
   Search Chromatin IP Primers for ATM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22-q23

ATM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P108093:  view genomic region     (about GC identifiers)

Start:
108,093,211 bp from pter      End:
108,239,829 bp from pter
Size:
146,619 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 (See protein sequence)
Recommended Name: Serine-protein kinase ATM  
Size: 3056 amino acids; 350687 Da
Subunit: Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers
rendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the
BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and
the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell
cycle and within subnuclear domains. Interacts with RAD17; DNA damage promotes the association. Interacts with
EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, KAT8, KAT5, NABP2,
ATMIN and CEP164. Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity).
Interacts with TELO2 and TTI1. Interacts with DDX1
Sequence caution: Sequence=AAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA86520.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI37170.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI37170.1; Type=Miscellaneous
discrepancy; Note=Probable cloning artifact; Sequence=EAW67111.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RNX5 O15429 Q12758 Q16551 Q93007 Q9NP02 Q9UCX7

Explore the universe of human proteins at neXtProt for ATM: NX_Q13315

Explore proteomics data for ATM at MOPED

Post-translational modifications: 

  • Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA
    damage-mediated activation of the kinase1
  • Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and
    subsequent autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP601
  • Ubiquitination2 at Lys215, Lys1109, Lys1114, Lys1126, Lys1323, Lys1572, Lys1994, Lys2025, Lys2148, Lys2160,
                                 Lys2789, Lys2848
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATM (Q13315) (see all 6)
     TYKVVPL  EPDSLYG  EGVFRRC  DDLRQDA 


    See ATM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000042.3  
    ENSEMBL proteins: 
     ENSP00000435747   ENSP00000433955   ENSP00000432318   ENSP00000388058   ENSP00000469471  
     ENSP00000434327   ENSP00000435524   ENSP00000278616  
    Reactome Protein details: Q13315

    ATM Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ATM Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ATM
    GenScript Custom Purified and Recombinant Proteins Services for ATM
    Novus Biologicals ATM Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATM

     
    Search eBioscience for Proteins for ATM 

    ATM Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATM
    R&D Systems Antibodies for ATM
    Cell Signaling Technology (CST) Antibodies for ATM 
    OriGene Antibodies for ATM
    OriGene Custom Antibody Services for ATM
    Novus Biologicals ATM Antibodies
    Abcam antibodies for ATM
    Cloud-Clone Corp. Antibodies for ATM
    ThermoFisher Antibody for ATM
    LSBio Antibodies in human, mouse, rat for ATM

    ATM Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATM
    R&D Systems ELISAs for ATM
    GenScript Custom Assay Services for ATM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATM
    Cloud-Clone Corp. CLIAs for ATM
    Search eBioscience for ELISAs for ATM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: ataxia telangiectasia mutated
    Other PIKK family kinases

    Selected InterPro protein domains (see all 8):
     IPR011009 Kinase-like_dom
     IPR021668 TAN
     IPR014009 PIK_FAT
     IPR000403 PI3/4_kinase_cat_dom
     IPR003151 PIK-rel_kinase_FAT

    Graphical View of Domain Structure for InterPro Entry Q13315

    ProtoNet protein and cluster: Q13315

    2 Blocks protein domains:
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003151 PIK-related kinase


    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
    Domain: The FATC domain is required for interaction with KAT5
    Similarity: Belongs to the PI3/PI4-kinase family. ATM subfamily
    Similarity: Contains 1 FAT domain
    Similarity: Contains 1 FATC domain
    Similarity: Contains 1 PI3K/PI4K domain


    Find genes that share domains with ATM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATM_HUMAN, Q13315
    Function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),
    apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage
    sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant
    H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in
    pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to
    enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual
    B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by
    mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to
    the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle
    control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2,
    CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle
    and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role
    in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in
    response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation.
    Phosphorylates ATF2 which stimulates its function in DNA damage response
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by wortmannin
    Induction: By ionizing radiation

         Genatlas biochemistry entry for ATM:
    ataxia telangiectasia,mutated,protein kinase,involved in cellular responses to ionizing radiation (IR)-induced DNA
    damage such as double strand breaks and cell cycle control through phosphorylation of BRCA1,homologous to cell
    cycle G2 checkpoint gene yeast MEC1 and related TEL1,RAD3 (S pombe),Drosophila mei-41,also homologous to yeast
    TOR1,TOR2, activating TP53 in association with 14.3.3 proteins YWHA*,and leading to cell cycle arrest and
    apoptosis,also activating ABL1 (cABL) and TP73 in a mismatch repair dependent apoptosis pathway,interacting with
    beta adaptin for the axonal transport and vesicle trafficking in the central nervous system,mutated (somatic
    mutation) in B cell chronic lymphocytic leukemia,also mutated in ataxia telangiectasia (see AT),but not mutated
    in childhood T-ALL,deleted in mantle cell lymphoma (see also TSG11F)

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA11375976
    GO:0004677DNA-dependent protein kinase activity IDA15790808
    GO:0005488binding ----
         
    Find genes that share ontologies with ATM           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ATM:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  PARP inhibitor sensitization 

         11 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Atm):
     behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  immune system  mortality/aging  nervous system  reproductive system 
     tumorigenesis 

    Find genes that share phenotypes with ATM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ATM: Atmtm1Pmc Atmtm1Awb Atmtm1Led Atmtm1Bal Atmtm1Fwa Atmtm1Mfl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATM

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATM:
    hsa-mir-374a-5p (MIRT005573), hsa-mir-19b-3p (MIRT031122), hsa-mir-18a-5p (MIRT006118), hsa-mir-100-5p (MIRT005913), hsa-mir-101-5p (MIRT005559), hsa-mir-3144-3p (MIRT052661), hsa-mir-421 (MIRT003215), hsa-mir-101-3p (MIRT005560), hsa-mir-181a-5p (MIRT005576), hsa-mir-92a-3p (MIRT049505)

    Block miRNA regulation of human, mouse, rat ATM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATM (see all 15):
    hsa-miR-34c-3p hsa-miR-203 hsa-miR-18a hsa-miR-181c hsa-miR-516b hsa-miR-181a hsa-miR-519c-3p hsa-miR-181d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATM
    Predesigned siRNA for gene silencing in human, mouse, rat ATM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATM

    Clone
    Products:
         
    OriGene clones in human, mouse for ATM (see all 9)
    OriGene ORF clones in mouse, rat for ATM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATM (NM_000051)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATM
    Addgene plasmids for ATM 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATM
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12375) for ATM 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATM_HUMAN, Q13315: Nucleus. Cytoplasmic vesicle. Note=Primarily nuclear. Found also in endocytic vesicles in
    association with beta-adaptin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3
    cytoskeleton2
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781colocalizes with chromosome, telomeric region IDA15149599
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005819spindle IEA--

    Find genes that share ontologies with ATM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATM About   (see all 51)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    3CDK-mediated phosphorylation and removal of Cdc6
    Stabilization of p530.92
    p53-Independent DNA Damage Response0.91
    p53-Dependent G1 DNA Damage Response0.92
    Autodegradation of the E3 ubiquitin ligase COP10.91
    p53-Dependent G1/S DNA damage checkpoint0.92
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A0.91
    Cell Cycle Checkpoints0.58
    4Homologous Recombination Repair
    Homologous Recombination Repair0.70
    Recruitment of repair and signaling proteins to double-strand breaks0.00
    Double-Strand Break Repair0.70
    Homologous recombination repair of replication-independent double-strand breaks0.00
    ATM mediated response to DNA double-strand break0.31
    ATM mediated phosphorylation of repair proteins0.00
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    p53 Mediated Apoptosis0.84
    Cellular Apoptosis Pathway0.85
    Telomerase Components in Cell Signaling0.72


    Find genes that share SuperPaths with ATM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATM (see all 17)
        Telomerase Components in Cell Signaling
    BRCA1 Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    2 Cell Signaling Technology (CST) Pathways for ATM
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 Tocris Bioscience Pathway for ATM
        Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for ATM
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription P53 signaling pathway
    DNA damage DNA-damage-induced responses
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for ATM (see all 19)
        Cell cycle
    DNA damage response
    G1 to S cell cycle control
    DNA damage response (only ATM dependent)
    Homologous recombination

    Selected Reactome Pathways for ATM (see all 11)
        ATM mediated response to DNA double-strand break
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    Regulation of HSF1-mediated heat shock response
    Regulation of the Fanconi anemia pathway
    Stabilization of p53

    1 PharmGKB Pathway for ATM
        Metformin Pathway, Pharmacodynamic

    Selected Kegg Pathways  (Kegg details for ATM) (see all 8):
        NF-kappa B signaling pathway
    FoxO signaling pathway
    Cell cycle
    p53 signaling pathway
    Apoptosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATM (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ATM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATM (Q133151, 2, 3 ENSP000002786164) via UniProtKB, MINT, STRING, and/or I2D (see all 854)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206481Q146761, 3, ENSP000003730604EBI-495465,EBI-495644 I2D: score=4 STRING: ENSP00000373060
    ENSG00000237095Q146761, 3, ENSP000004091674EBI-495465,EBI-495644 I2D: score=4 STRING: ENSP00000409167
    MDC1Q146761, 3, ENSP000003655884EBI-495465,EBI-495644 I2D: score=4 STRING: ENSP00000365588
    ATMINO433131, 2, 3, ENSP000002995754EBI-495465,EBI-7422202 MINT-4979579 MINT-4979598 MINT-4979635 MINT-4979556 MINT-4979615 I2D: score=1 STRING: ENSP00000299575
    ENSG00000224587Q146761, 3EBI-495465,EBI-495644 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint ----
    GO:0000723telomere maintenance ----
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0001666response to hypoxia IEA--
    GO:0001756somitogenesis IEA--

    Find genes that share ontologies with ATM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    4 ApexBio Compounds for ATM     About this table
    CompoundAction CAS #
    AZ20potent and selective inhibitor of ATR[1233339-22-4]
    KU 55933Potent and selective ATM inhibitor[587871-26-9]
    KU-60019Potent and selective ATM kinase inhibitor[925701-49-1]
    VE-821Cell-permeable and ATP-competitive ATM kinase inhibitor[1232410-49-9]

    Compounds for ATM available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KU 55933Potent and selective ATM kinase inhibitor[587871-26-9]
    KU 60019Potent ATM kinase inhibitor[925701-46-8]

    2 HMDB Compounds for ATM    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for ATM gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 58.6 27 11114307 (1), 17507690 (1), 9442910 (1), 12513844 (1) (see all 24)
    wortmannin 56.5 24 10771089 (3), 15173573 (2), 9808536 (2), 15709017 (1) (see all 14)
    neocarzinostatin 50.7 3 15345673 (1), 9244351 (1), 9050866 (1)
    caffeine 50.2 33 10485486 (4), 16479016 (2), 11864911 (2), 10744722 (2) (see all 19)
    aphidicolin 46.5 5 11279043 (1), 11114888 (1)
    hydroxyurea 43.4 6 11689451 (1), 16293623 (1), 11114888 (1)
    topotecan 35.2 11 18802408 (3), 16426422 (3), 16760673 (2), 16184611 (1)
    camptothecin 32.1 15 20304914 (5), 15699047 (2), 16158199 (1), 10327072 (1)
    mitoxantrone 30.9 10 16760673 (4), 18802408 (3), 16184611 (1), 19411853 (1)
    ly294002 30.4 8 10771089 (3), 18589211 (1), 19038232 (1)



    Find genes that share compounds with ATM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATM gene (3 alternative transcripts): 
    NM_000051.3  NM_138292.3  NM_138293.1  

    Unigene Cluster for ATM:

    Ataxia telangiectasia mutated
    Hs.367437  [show with all ESTs]
    Unigene Representative Sequence: NM_000051
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000527805(uc009yxs.1) ENST00000527891 ENST00000532931 ENST00000530958
    ENST00000452508(uc001pke.2) ENST00000526567(uc001pkc.1) ENST00000601453
    ENST00000525012 ENST00000533526 ENST00000419286 ENST00000533733(uc001pkd.4)
    ENST00000524792 ENST00000531525(uc001pkf.3) ENST00000531957 ENST00000533690(uc009yxt.1 uc001pkg.1)
    ENST00000534625 ENST00000529588 ENST00000532765
    miRNA
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    Block miRNA regulation of human, mouse, rat ATM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATM (see all 15):
    hsa-miR-34c-3p hsa-miR-203 hsa-miR-18a hsa-miR-181c hsa-miR-516b hsa-miR-181a hsa-miR-519c-3p hsa-miR-181d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat ATM
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    GenScript: all cDNA clones in your preferred vector: ATM (NM_000051)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATM
    Addgene plasmids for ATM 
    Primer
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12375) for ATM 

    Additional mRNA sequence: 

    AF035326.1 AF035327.1 AF035328.1 AK093586.1 AK299843.1 BC007023.2 BC022306.1 BC061584.1 
    BC152385.1 BC152389.1 BT006764.1 BX640631.1 CR749436.1 HM437232.1 U33841.1 U67093.1 
    X91196.1 Y08455.1 

    21 DOTS entries:

    DT.102832095  DT.100750015  DT.91916232  DT.91717023  DT.101977439  DT.99971554  DT.121643246  DT.451837 
    DT.100750014  DT.99928041  DT.120760397  DT.65284599  DT.97778369  DT.120760409  DT.120760428  DT.40122485 
    DT.75194025  DT.91664691  DT.97825561  DT.120760412  DT.99957611 

    Selected AceView cDNA sequences (see all 200):

    AI523344 NM_000051 BX096702 AA962359 AI559463 AA890626 BM671057 BC007023 
    AA236739 AA149636 U26455 BM697241 BG942504 BM800438 AA814352 NM_138292 
    BX642224 BX504088 BX644571 R26821 BQ005085 AI479273 CA392919 AV705298 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ATM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ATM Expression
    About this image


    ATM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Gonad
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primordial Follicle
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    ATM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367437

    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
    Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen,
    thymus, testis, ovary, small intestine, colon and leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATM (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATM gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atm1 , 5 ataxia telangiectasia mutated homolog (human)1, 5 84.99(n)1
    84.34(a)1
      9 (29.12 cM)5
    119201  NM_007499.21  NP_031525.21 
     534391495 
    chicken
    (Gallus gallus)
    Aves ATM1 ataxia telangiectasia mutated 72.23(n)
    69.69(a)
      395401  NM_001162400.1  NP_001155872.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATM6
    ataxia telangiectasia mutated
    60(a)
    1 ↔ 1
    GL343319.1(1173-53757)
    African clawed frog
    (Xenopus laevis)
    Amphibia ATM2 ataxia telangiectasia mutated 75.21(n)    AF174488.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.286552 Danio rerio partial mRNA for ataxia telangiectasia more 73.34(n)    AJ605775.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65353 cell cycle checkpoint protein kinase 27(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea atm-16
    Protein ATM-1 (atm-1) mRNA, complete cds
    18(a)
    1 ↔ 1
    I(183364-208467) WBGene00000227
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TEL1(YBL088C)4 Protein kinase primarily involved in telomere length more   --   2(59382-51019) 852190  NP_009465.1 
    rice
    (Oryza sativa)
    Liliopsida Os.170832 Oryza sativa (japonica cultivar-group) AtATM like protein more 75(n)    NM_183488.1 


    ENSEMBL Gene Tree for ATM (if available)
    TreeFam Gene Tree for ATM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATM gene
    1 SIMAP similar gene for ATM using alignment to 14 protein entries:     ATM_HUMAN (see all proteins):
    DKFZp781A0353

    Find genes that share paralogs with ATM           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ATM
    PGOHUM00000233233


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATM (see all 3368)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30928571,2,,4
    C,F,HB-cell non-Hodgkin lymphoma4 other1108007477(+) TAAGAA/GTGGCC 2 M V mis126Minor allele frequency- G:0.01NA MN NS EA 7154
    VAR_0108014
    Ataxia telangiectasia (AT)4--see VAR_0108012 K E mis40--------
    VAR_0108464
    Ataxia telangiectasia (AT)4--see VAR_0108462 R C mis40--------
    VAR_0108794
    Ataxia telangiectasia (AT)4--see VAR_0108792 F C mis40--------
    VAR_0108164
    Ataxia telangiectasia (AT)4--see VAR_0108162 L Q mis40--------
    VAR_0108634
    Ataxia telangiectasia (AT)4--see VAR_0108632 D Q mis40--------
    VAR_0415804
    A lung adenocarcinoma sample4--see VAR_0415802 T A mis40--------
    VAR_0108804
    Ataxia telangiectasia (AT)4--see VAR_0108802 P L mis40--------
    VAR_0108264
    Ataxia telangiectasia (AT)4--see VAR_0108262 L P mis40--------
    VAR_0108904
    Ataxia telangiectasia (AT)4--see VAR_0108902 R G mis40--------

    HapMap Linkage Disequilibrium report for ATM (108093211 - 108239829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ATM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832262CNV Loss17160897
    dgv1315n71CNV Loss21882294
    nsv898385CNV Loss21882294
    nsv832263CNV Gain17160897

    Human Gene Mutation Database (HGMD): ATM
    Locus Specific Mutation Databases (LSDB): ATM

    Selected Site Specific Mutation Identification with PCR Assays for ATM (see all 6):
    Cosmic IdAA Change
    20404p.R2443Q
    21826p.F858L
    21624p.R3047*
    12951p.Q2442P
    21642p.R3008C
    5 Site Specific Cancer Mutation PCR Panels containing ATM:
    Lymphoid Neoplasms
    Lung and Colon Cancers (Expanded Panel) 384HT
    Pathway
    Cancer Comprehensive Panel 384HT
    Tumor Suppressor Panel 384HT
    SeqTarget long-range PCR primers for resequencing ATM
    DNA2.0 Custom Variant and Variant Library Synthesis for ATM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 607585   
    OMIM disorders: 208900  114480  
    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
  • Ataxia telangiectasia (AT) [MIM:208900]: A rare recessive disorder characterized by progressive
    cerebellar ataxia, dilation of the blood vessels in the conjunctiva and eyeballs, immunodeficiency, growth
    retardation and sexual immaturity. Patients have a strong predisposition to cancer; about 30% of patients develop
    tumors, particularly lymphomas and leukemias. Cells from affected individuals are highly sensitive to damage by
    ionizing radiation and resistant to inhibition of DNA synthesis following irradiation. Note=The disease is caused
    by mutations affecting the gene represented in this entry
  • Note=Defects in ATM contribute to T-cell acute lymphoblastic leukemia (TALL) and T-prolymphocytic
    leukemia (TPLL). TPLL is characterized by a high white blood cell count, with a predominance of prolymphocytes,
    marked splenomegaly, lymphadenopathy, skin lesions and serous effusion. The clinical course is highly aggressive,
    with poor response to chemotherapy and short survival time. TPLL occurs both in adults as a sporadic disease and
    in younger AT patients
  • Note=Defects in ATM contribute to B-cell non-Hodgkin lymphomas (BNHL), including mantle cell lymphoma
    (MCL)
  • Note=Defects in ATM contribute to B-cell chronic lymphocytic leukemia (BCLL). BCLL is the commonest form
    of leukemia in the elderly. It is characterized by the accumulation of mature CD5+ B-lymphocytes,
    lymphadenopathy, immunodeficiency and bone marrow failure

  • 26 diseases for ATM (see first 20):    
    About MalaCards
    b-cell chronic lymphocytic leukemia    chromosome 11q deletion    mantle cell lymphoma    ataxia-telangiectasia variant
    t-cell prolymphocytic leukemia, somatic    lymphoma, b-cell non-hodgkin, somatic    combined cervical dystonia    ataxia telangiectasia
    nijmegen breakage syndrome-like disorder    cll/sll    t-cell prolymphocytic leukemia    ataxia
    campomelic dysplasia with autosomal sex reversal    campomelic dysplasia    nijmegen breakage syndrome    breast cancer
    bilateral breast cancer    chronic lymphocytic leukemia    telangiectasis    prolymphocytic leukemia
    familial chronic lymphocytic leukemia    cervical dystonia    breast cancer, somatic    breast cancer susceptibility
    asphyxiating thoracic dystrophy    ovarian cancer

    10 diseases from the University of Copenhagen DISEASES database for ATM:
    Ataxia telangiectasia     Nijmegen breakage syndrome     Breast cancer     Genetic disorder
    Telangiectasis     Cerebellar ataxia     Leukemia     Lymphoma
    Fanconi's anemia     Seckel syndrome

    Find genes that share disorders with ATM           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ATM gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 98.2 473 9622061 (3), 16799570 (3), 7545545 (2), 8843194 (2) (see all 99)
    nijmegen breakage syndrome 87.5 20 15024084 (1), 17507690 (1), 18215521 (1), 18723444 (1) (see all 17)
    cerebellar degeneration 77.4 4 9054948 (1), 9770541 (1), 8968760 (1), 11443540 (1)
    telangiectasia 70.7 13 12882767 (4), 18502988 (2), 19799357 (1), 12513844 (1) (see all 8)
    genetic disorder 69.8 40 10549596 (2), 7545545 (1), 9535798 (1), 10567403 (1) (see all 39)
    lymphocytic leukemia chronic b-cell 65.4 16 11468183 (2), 9892178 (1), 9788599 (1), 10738255 (1) (see all 14)
    cancer 63.5 122 12513844 (4), 18565893 (4), 12195425 (3), 15390180 (3) (see all 83)
    leukemia prolymphocytic 62.7 8 9573030 (2), 10738255 (1), 12149228 (1), 18073348 (1) (see all 7)
    bilateral breast cancer 60.9 10 19153073 (3), 12673797 (1), 14562025 (1), 15756685 (1) (see all 5)
    fanconis anemia 59.3 1 11733219 (1)

    GeneTests: ATM
    GeneReviews: ATM
    Genetic Association Database (GAD): ATM
    Human Genome Epidemiology (HuGE) Navigator: ATM (170 documents)
    Tumor Gene Database (TGDB): ATM

    Export disorders for ATM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ATM gene, integrated from 10 sources (see all 1426):
    (articles sorted by number of sources associating them with ATM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations associated with variant phenotypes in ataxia- telangiectasia. (PubMed id 8755918)1, 2, 4 McConville C.M.... Taylor A.M.R. (Am. J. Hum. Genet. 1996)
    2. ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects. (PubMed id 11849780)1, 4, 9 Iannuzzi C.M....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2002)
    3. Inactivation of the ATM gene in T-cell prolymphocytic leukemias. (PubMed id 9573030)1, 2, 9 Stoppa-Lyonnet D.... Stern M.-H. (Blood 1998)
    4. Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene. (PubMed id 9199932)1, 2, 9 Platzer M.... Rosenthal A. (Genome Res. 1997)
    5. Contribution of mutations in ATM to breast cancer development in the Czech population. (PubMed id 18497957)1, 4, 9 Soukupova J....Pohlreich P. (Oncol. Rep. 2008)
    6. Detection of ATM gene mutations in young lung cancer patients: a population-based control study. (PubMed id 18164969)1, 4, 9 Schneider J....Wichmann H.E. (Arch. Med. Res. 2008)
    7. The product of the ATM gene is a 370-kDa nuclear phosphoprotein. (PubMed id 8969240)1, 2, 9 Chen G. and Lee E.Y.-H.P. (J. Biol. Chem. 1996)
    8. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. (PubMed id 17923702)1, 2, 9 Sun Y.... Price B.D. (Mol. Cell. Biol. 2007)
    9. Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity. (PubMed id 10873394)1, 2, 9 Becker-Catania S.G.... Gatti R.A. (Mol. Genet. Metab. 2000)
    10. Mantle cell lymphoma is characterized by inactivation of the ATM gene. (PubMed id 10706620)1, 2, 9 Schaffner C.... Lichter P. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 472 HGNC: 795 AceView: ATM Ensembl:ENSG00000149311 euGenes: HUgn472
    ECgene: ATM Kegg: 472 H-InvDB: ATM

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATM Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ATM[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/atm/
    Wikipedia http://en.wikipedia.org/wiki/Ataxia_telangiectasia_mutated

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATM gene:
    Search GeneIP for patents involving ATM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat ATM using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ATM
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATM
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      Search eBioscience for proteins for ATM
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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