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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATM Gene

protein-coding   GIFtS: 76
GCID: GC11P108093

ataxia telangiectasia mutated

(Previous names: ataxia telangiectasia mutated (includes complementation...)
(Previous symbols: ATA, ATDC, ATC, ATD)
 Explore 140 diseases affiliated with
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Biological research products
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Aliases
for ATM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ataxia Telangiectasia Mutated1 2 3     EC 2.7.11.13 8
ATA1 2 5     AT12 5
ATC1 2     Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C And D)1
ATD1 2     ATE2
ATDC1 2     AT Mutated2
TEL11 2     Serine-Protein Kinase ATM2
TELO11 2     TEL1, Telomere Maintenance 1, Homolog2
A-T Mutated2 3     

External Ids:    HGNC: 7951   Entrez Gene: 4722   Ensembl: ENSG000001493117   OMIM: 6075855   UniProtKB: Q133153   

Export aliases for ATM gene to outside databases

Previous GC identifers: GC11P110302 GC11P109450 GC11P108127 GC11P107631 GC11P107599 GC11P104019


Summaries
for ATM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ATM:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle
checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins,
including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA
repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell
cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.
Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. (provided by
RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
Function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),
apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor.
Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double
strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic
exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and
monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the
introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the
second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the
second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor.
Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin
(NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell
development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds
DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated
ubiquitination and subsequent proteasome degradation

summary for ATM:
ATM (Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related) are closely related
kinases that are activated by DNA damage. These serine-threonine protein kinases are part of the
phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding
proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by
phosphorylating a number of key proteins. Once activated, the checkpoint leads to cell cycle arrest and
either DNA repair or apoptosis. ATM is activated by double stranded breaks and phosphorylates Chk2, whilst
ATR is activated by single strand breaks and phosphorylates Chk1.

Gene Wiki entry for ATM (Ataxia telangiectasia mutated)


Genomic Views
for ATM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATM gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ATM promoter sequence
   Search SABiosciences Chromatin IP Primers for ATM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22-q23

ATM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P108093:  view genomic region     (about GC identifiers)

Start:
 108,093,211 bp from pter      End:
 108,239,829 bp from pter
Size:
 146,619 bases      Orientation:
 plus strand

Proteins
for ATM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 (See protein sequence)
Recommended Name: Serine-protein kinase ATM  
Size: 3056 amino acids; 350714 Da
Subunit: Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers
rendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated
genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN
protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear
domains. Interacts with RAD17; DNA damage promotes the association. Interacts with EEF1E1; the interaction, induced on
DNA damage, up-regulates TP53. Interacts with DCLRE1C, KAT8, KAT5, NABP2, ATMIN and CEP164. Interacts with AP2B1 and
AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity). Interacts with TELO2 and TTI1. Interacts with
DDX1
Subcellular location: Nucleus. Cytoplasmic vesicle. Note=Primarily nuclear. Found also in endocytic vesicles in
association with beta-adaptin
Sequence caution: Sequence=AAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA86520.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI37170.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI37170.1; Type=Miscellaneous
discrepancy; Note=Probable cloning artifact; Sequence=EAW67111.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RNX5 O15429 Q12758 Q16551 Q93007 Q9NP02 Q9UCX7

Explore the universe of human proteins at neXtProt for ATM: NX_Q13315

Post-translational modifications:

  • Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated
    • activation of the kinase1
  • Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent
    • autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP601
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13315

    • 4/6 DME Specific Peptides for ATM (Q13315) (see all 6)
     TYKVVPL  EPDSLYG  EGVFRRC  DDLRQDA 

    ATM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000042.3  
    ENSEMBL proteins: 
     ENSP00000435747   ENSP00000433955   ENSP00000432318   ENSP00000388058   ENSP00000432560  
     ENSP00000431839   ENSP00000434327   ENSP00000435524   ENSP00000278616  
    Reactome Protein details: Q13315
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant ATM Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ATM 
    GenScript Custom Purified and Recombinant Proteins Services for ATM
    Novus Biologicals ATM Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ATM

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781colocalizes with chromosome, telomeric region IDA15149599
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005819spindle IEA--


    ATM for ontologies           About GeneDecksing



    ATM Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATM
    R&D Systems Antibodies for ATM
    Cell Signaling Technology (CST) Antibodies for ATM 
    OriGene Antibodies (see all 3): ATM
    OriGene Custom Antibody Services for ATM 
    GenScript Custom Superior Antibodies Services for ATM
    Novus Biologicals ATM Antibodies
    Abcam antibodies for ATM 
    Uscn Antibodies for ATM
    ThermoFisher Antibody for ATM

    Assay Products for ATM: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for ATM
    GenScript Custom Assay Services for ATM
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ATM

    Protein Domains /
    Families
    for ATM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATM for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR000403 PI3/4_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR021668 TAN
     IPR003151 PIK-rel_kinase_FAT
     IPR015519 ATM/Tel1

    Graphical View of Domain Structure for InterPro Entry Q13315

    ProtoNet protein and cluster: Q13315

    2 Blocks protein families:
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003151 PIK-related kinase


    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
    Domain: The FATC domain is required for interaction with KAT5
    Similarity: Belongs to the PI3/PI4-kinase family. ATM subfamily
    Similarity: Contains 1 FAT domain
    Similarity: Contains 1 FATC domain
    Similarity: Contains 1 PI3K/PI4K domain


    Function
    for ATM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
    Function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),
    apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor.
    Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double
    strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic
    exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and
    monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the
    introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the
    second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the
    second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor.
    Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin
    (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell
    development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds
    DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated
    ubiquitination and subsequent proteasome degradation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by wortmannin
    Induction: By ionizing radiation

         Genatlas biochemistry entry for ATM:
    ataxia telangiectasia,mutated,protein kinase,involved in cellular responses to ionizing radiation (IR)-induced DNA
    damage such as double strand breaks and cell cycle control through phosphorylation of BRCA1,homologous to cell cycle
    G2 checkpoint gene yeast MEC1 and related TEL1,RAD3 (S pombe),Drosophila mei-41,also homologous to yeast TOR1,TOR2,
    activating TP53 in association with 14.3.3 proteins YWHA*,and leading to cell cycle arrest and apoptosis,also
    activating ABL1 (cABL) and TP73 in a mismatch repair dependent apoptosis pathway,interacting with beta adaptin for the
    axonal transport and vesicle trafficking in the central nervous system,mutated (somatic mutation) in B cell chronic
    lymphocytic leukemia,also mutated in ataxia telangiectasia (see AT),but not mutated in childhood T-ALL,deleted in
    mantle cell lymphoma (see also TSG11F)

    Enzyme Number (IUBMB): EC 2.7.11.11 2

    miRNA
    Products:            		miRTarBase miRNAs that target ATM:
    hsa-mir-374a (MIRT005573), hsa-mir-421 (MIRT003215), hsa-mir-101 (MIRT005560), hsa-mir-100 (MIRT005913), hsa-mir-181a (MIRT005576), hsa-mir-101 (MIRT005559)

    OriGene 3'-UTR Clone (see all 2): ATM
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATM
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ATM (see all 15):
    hsa-miR-34c-3p hsa-miR-203 hsa-miR-18a hsa-miR-181c hsa-miR-516b hsa-miR-181a hsa-miR-519c-3p hsa-miR-181d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATM (see all 7)
    OriGene shRNA RFP: ATM
    OriGene siRNA: ATM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATM

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ATM

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATM (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATM (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ATM (NM_000051)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATM 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ATM
    Search LifeMap BioReagents cell lines for ATM

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA9733515
    GO:0004677DNA-dependent protein kinase activity IDA15790808
    GO:0005515protein binding IPI--


    ATM for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ATM:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  PARP inhibitor sensitization 

    Animal Models:
         Mouse knock-outs for ATM: Atmtm1Pmc Atmtm1Awb Atmtm1Led Atmtm1Bal Atmtm1Fwa Atmtm1Mfl
         12 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Atm):
     behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  immune system  mortality/aging  nervous system  no phenotypic analysis 
     reproductive system  tumorigenesis 

    ATM for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/9 pathways (see all 9)
    		Autodegradation of the E3 ubiquitin ligase COP10.92
    		p53-Dependent G1/S DNA damage checkpoint0.83
    		Stabilization of p530.91
    		p53-Dependent G1 DNA Damage Response0.83
    		p53-Independent DNA Damage Response0.91
    		G1/S DNA Damage Checkpoints0.79
    		Ubiquitin Mediated Degradation of Phosphorylated Cdc25A0.91
    		Cell Cycle Checkpoints0.42
    2Fanconi Anemia pathway
    		Fanconi Anemia pathway1.00
    		Regulation of the Fanconi anemia pathway0.42
    		Fanconi's Anaemia Pathway0.43
    		BARD1 signaling events0.23
    3Chks in Checkpoint Regulation
    		Chks in Checkpoint Regulation1.00
    		p53 Signaling0.32
    		G2-M Phase Transition0.59
    		DNA Repair Mechanisms0.32
    4Formation of Meiotic Holliday Junction
    		Formation of Meiotic Holliday Junction1.00
    		Formation of Meiotic Single-stranded DNA Invasion Complex0.83
    		Formation of Meiotic Heteroduplex0.83
    		Resolution of Meiotic Holliday Junction0.31
    5Apoptotic Pathways in Synovial Fibroblasts
    		p53 Mediated Apoptosis0.84
    		Telomerase Components in Cell Signaling0.72
    		Mitochondrial Apoptosis0.73
    		Cellular Apoptosis Pathway0.65

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 EMD Millipore Pathways for ATM
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    DNA damage DNA-damage-induced responses
    Transcription P53 signaling pathway
    DNA damage Role of Brca1 and Brca2 in DNA repair

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATM (see all 17)
        Telomerase Components in Cell Signaling
    BRCA1 Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    2 Cell Signaling Technology (CST) Pathways for ATM
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 Tocris Bioscience Pathway for ATM
        Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for ATM
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription P53 signaling pathway
    DNA damage DNA-damage-induced responses
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/19 BioSystems Pathways for ATM (see all 19) 
        TP53 network
    DNA damage response (only ATM dependent)
    Signaling Pathways in Glioblastoma
    miRNAs involved in DDR
    Integrated Breast Cancer Pathway

    5/27        Reactome Pathways for ATM (see all 27)
        ATM mediated response to DNA double-strand break
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    DNA Repair
    Recruitment of repair and signaling proteins to double-strand breaks
    Cell Cycle

    1 PharmGKB Pathway for ATM
        Metformin Pathway, Pharmacodynamic

    3         Kegg Pathways  (Kegg details for ATM):
        Cell cycle
    p53 signaling pathway
    Apoptosis


    ATM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    641/680 Interacting proteins for ATM (Q133151, 2, 3 ENSP000002786164) via UniProtKB, MINT, STRING, and/or I2D (see all 680) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATMINO433132, 3, ENSP000002995754MINT-4979579 MINT-4979598 MINT-4979635 MINT-4979556 MINT-4979615 I2D: score=1 STRING: ENSP00000299575
    H2AFXP161042, 3, ENSP000003643104MINT-2843419 I2D: score=6 STRING: ENSP00000364310
    TP53P046372, 3, ENSP000002693054MINT-49767 I2D: score=6 STRING: ENSP00000269305
    MDC1Q146761, 3, ENSP000003655884EBI-1059333,EBI-495644 I2D: score=4 STRING: ENSP00000365588
    PRKDCP785272, 3, ENSP000003134204MINT-7945693 I2D: score=3 STRING: ENSP00000313420
    PPP1CAP621362, 3, ENSP000003260314MINT-7945693 I2D: score=2 STRING: ENSP00000326031
    TDP1Q9NUW82, 3, ENSP000003373534MINT-7543535 I2D: score=2 STRING: ENSP00000337353
    BLMP541322, 3, ENSP000003472324MINT-7945693 I2D: score=1 STRING: ENSP00000347232
    CHD4Q148392, 3, ENSP000003495084MINT-7945693 I2D: score=1 STRING: ENSP00000349508
    DDX1Q924992, 3, ENSP000002330844MINT-7945693 I2D: score=1 STRING: ENSP00000233084
    FANCIQ9NVI12, 3, ENSP000003108424MINT-7945693 I2D: score=1 STRING: ENSP00000310842
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 I2D: score=1 STRING: ENSP00000362649
    MLH1P406922, 3, ENSP000002317904MINT-7945693 I2D: score=1 STRING: ENSP00000231790
    MSH6P527012, 3, ENSP000002344204MINT-7945693 I2D: score=1 STRING: ENSP00000234420
    SMARCB1Q128242, 3, ENSP000002631214MINT-7945693 I2D: score=1 STRING: ENSP00000263121
    SMC3Q9UQE72, 3, ENSP000003547204MINT-7945693 I2D: score=1 STRING: ENSP00000354720
    UPF1Q929002, 3MINT-7945693 I2D: score=2 
    AP3B1O002032, 3MINT-7945693 I2D: score=1 
    IKBKGQ9Y6K92, 3, ENSP000003586224MINT-6978609 MINT-6978672 MINT-6978624 MINT-6978648 I2D: score=2 STRING: ENSP00000358622
    NBNO609342, 3, ENSP000002654334MINT-7945693 I2D: score=5 STRING: ENSP00000265433
    TELO2Q9Y4R81, 3, ENSP000002623194EBI-1059333,EBI-1047721 I2D: score=5 STRING: ENSP00000262319
    CHEK2O960172, 3, ENSP000003720234MINT-8052875 I2D: score=5 STRING: ENSP00000372023
    TERF1P542741, 3, ENSP000002766034EBI-1059333,EBI-710997 I2D: score=4 STRING: ENSP00000276603
    SMC1AQ146832, 3, ENSP000003234214MINT-7945693 I2D: score=4 STRING: ENSP00000323421
    TTI1O431561, 3, ENSP000003625464EBI-1059333,EBI-1055680 I2D: score=1 STRING: ENSP00000362546
    AP1B1Q105672, 3, ENSP000003501994MINT-7945693 I2D: score=6 STRING: ENSP00000350199
    ATRQ135352, 3, ENSP000003437414MINT-7945693 I2D: score=1 STRING: ENSP00000343741
    CHEK1O147572, 3, ENSP000002789164MINT-7945693 I2D: score=3 STRING: ENSP00000278916
    MRE11AP499592, 3, ENSP000003258634MINT-7945693 I2D: score=4 STRING: ENSP00000325863
    NABP2Q9BQ151, 3, ENSP000002670234EBI-1059333,EBI-2120336 I2D: score=1 STRING: ENSP00000267023
    AATFQ9NY611, 3, ENSP000002254024EBI-1059333,EBI-372428 I2D: score=3 STRING: ENSP00000225402
    MSH2P432462, 3, ENSP000002331464MINT-7945693 I2D: score=1 STRING: ENSP00000233146
    RAD50Q928782, 3, ENSP000002653354MINT-7945693 I2D: score=1 STRING: ENSP00000265335
    BRCA1P383983, ENSP000003502834I2D: score=5 STRING: ENSP00000350283
    RHEBQ153823, ENSP000002621874I2D: score=5 STRING: ENSP00000262187
    ABL1P005193, ENSP000003614234I2D: score=4 STRING: ENSP00000361423
    EIF4EBP1Q135413, ENSP000003406914I2D: score=4 STRING: ENSP00000340691
    RAD17O759433, ENSP000003701514I2D: score=4 STRING: ENSP00000370151
    E2F1Q010943, ENSP000003455714I2D: score=3 STRING: ENSP00000345571
    EEF1E1O433243, ENSP000003690384I2D: score=3 STRING: ENSP00000369038
    RBBP8Q997083, ENSP000003230504I2D: score=3 STRING: ENSP00000323050
    AP3B2Q133673, ENSP000002617224I2D: score=2 STRING: ENSP00000261722
    E4F1Q66K893, ENSP000003017274I2D: score=2 STRING: ENSP00000301727
    LIG4P499173, ENSP000003493934I2D: score=2 STRING: ENSP00000349393
    MDM4O151513, ENSP000003561504I2D: score=2 STRING: ENSP00000356150
    RAD51Q066093, ENSP000002678684I2D: score=2 STRING: ENSP00000267868
    RAD9AQ996383, ENSP000003113604I2D: score=2 STRING: ENSP00000311360
    XPAP230253, ENSP000003642704I2D: score=2 STRING: ENSP00000364270
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    BIDP559573, ENSP000003188224I2D: score=1 STRING: ENSP00000318822
    CDC6Q997413, ENSP000002097284I2D: score=1 STRING: ENSP00000209728
    CXXC5Q7LFL83, ENSP000003025434I2D: score=1 STRING: ENSP00000302543
    FOXO3O435243, ENSP000003395274I2D: score=1 STRING: ENSP00000339527
    IGBP1P783183, ENSP000003487844I2D: score=1 STRING: ENSP00000348784
    MCPH1Q8NEM03, ENSP000003429244I2D: score=1 STRING: ENSP00000342924
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
    PPP1CCP368733, ENSP000003350844I2D: score=1 STRING: ENSP00000335084
    RFC1P352513, ENSP000002614244I2D: score=1 STRING: ENSP00000261424
    RNF8O760643, ENSP000003625784I2D: score=1 STRING: ENSP00000362578
    RPA2P159273, ENSP000003630214I2D: score=1 STRING: ENSP00000363021
    RRM2BQ7LG563, ENSP000002518104I2D: score=1 STRING: ENSP00000251810
    TAOK3Q9H2K83, ENSP000003763174I2D: score=1 STRING: ENSP00000376317
    XPCQ018313, ENSP000002850214I2D: score=1 STRING: ENSP00000285021
    TP53BP1Q128883, ENSP000003714754I2D: score=3 STRING: ENSP00000371475
    KAT5Q929933, ENSP000003403304I2D: score=2 STRING: ENSP00000340330
    TRIM28Q132632, ENSP000002530244MINT-7945693 STRING: ENSP00000253024
    CREB1P162203, ENSP000003876994I2D: score=2 STRING: ENSP00000387699
    ATF2P153363, ENSP000002641104I2D: score=2 STRING: ENSP00000264110
    BMI1P352263, ENSP000003658514I2D: score=1 STRING: ENSP00000365851
    WRNQ141913, ENSP000002981394I2D: score=3 STRING: ENSP00000298139
    FANCD2Q9BXW93, ENSP000002876474I2D: score=2 STRING: ENSP00000287647
    VHLP403373, ENSP000002564744I2D: score=2 STRING: ENSP00000256474
    AP2B1P630103, ENSP000003144144I2D: score=2 STRING: ENSP00000314414
    BRCA2P515873, ENSP000003694974I2D: score=1 STRING: ENSP00000369497
    DCLRE1AQ6PJP83, ENSP000003551854I2D: score=1 STRING: ENSP00000355185
    EIF3EP602282, ENSP000002208494MINT-7945693 STRING: ENSP00000220849
    EXO1Q9UQ843, ENSP000003118734I2D: score=1 STRING: ENSP00000311873
    KAT8Q9H7Z63, ENSP000004060374I2D: score=1 STRING: ENSP00000406037
    PER3P566452, ENSP000003550314MINT-8052875 STRING: ENSP00000355031
    PEX5P505423, ENSP000004074014I2D: score=2 STRING: ENSP00000407401
    STK11Q158313, ENSP000003248564I2D: score=1 STRING: ENSP00000324856
    TIPARPQ7Z3E13, ENSP000002959244I2D: score=2 STRING: ENSP00000295924
    TOPBP1Q925473, ENSP000002608104I2D: score=2 STRING: ENSP00000260810
    DCLRE1CQ96SD13, ENSP000003675274I2D: score=1 STRING: ENSP00000367527
    HUWE1Q7Z6Z73, ENSP000002628544I2D: score=1 STRING: ENSP00000262854
    MCM2P497363, ENSP000002650564I2D: score=1 STRING: ENSP00000265056
    USP34Q70CQ23, ENSP000003815774I2D: score=1 STRING: ENSP00000381577
    DYRK2Q926303, ENSP000003421054I2D: score=1 STRING: ENSP00000342105
    HNRNPUL1Q9BUJ23, ENSP000003758634I2D: score=1 STRING: ENSP00000375863
    SFNP319473, ENSP000003409894I2D: score=1 STRING: ENSP00000340989
    SREBF1P369563, ENSP000003480694I2D: score=1 STRING: ENSP00000348069
    RUVBL1Q9Y2652, ENSP000003182974MINT-7945693 STRING: ENSP00000318297
    AP2A2O949733, ENSP000004132344I2D: score=1 STRING: ENSP00000413234
    PTSQ033933, ENSP000002803624I2D: score=1 STRING: ENSP00000280362
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ATRIPQ8WXE13, ENSP000003230994I2D: score=2 STRING: ENSP00000323099
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    PPP2R1BP301542, ENSP000003113444MINT-7945693 STRING: ENSP00000311344
    ELAVL1Q157172, ENSP000003852694MINT-7945693 STRING: ENSP00000385269
    PPP2R1AP301532, ENSP000003248044MINT-7945693 STRING: ENSP00000324804
    SNW1Q135732, ENSP000002615314MINT-7945693 STRING: ENSP00000261531
    TAOK1Q7L7X32, ENSP000002617164MINT-7945693 STRING: ENSP00000261716
    XRCC5P130103I2D: score=3 
    ESPL1Q146743I2D: score=1 
    IKBKBO149203I2D: score=1 
    RASSF1Q9NS233I2D: score=1 
    STAT1P422243I2D: score=1 
    TCL1AP562793I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    TREX1Q9NSU23I2D: score=1 
    ABCF1Q8NE712MINT-7945693
    ABCF3Q9NUQ82MINT-7945693
    ACIN1Q9UKV32MINT-7945693
    ACTBP607092MINT-7945693
    ACTL6AO960192MINT-7945693
    ACTR1AP611632MINT-7945693
    ACTR2P611602MINT-7945693
    ADNPQ9H2P02MINT-7945693
    AHNAKQ096662MINT-7945693
    ANAPC1Q9H1A42MINT-7945693
    ANLNQ9NQW62MINT-7945693
    APBB1IPQ7Z5R62MINT-7945693
    API5Q9BZZ52MINT-7945693
    AQRO603062MINT-7945693
    ARAP1Q96P482MINT-7945693
    ARCN1P484442MINT-7945693
    ARF4P180852MINT-7945693
    ARF5P840852MINT-7945693
    ARFGEF2Q9Y6D52MINT-7945693
    ARHGEF1Q928882MINT-7945693
    ARHGEF2Q929742MINT-7945693
    ARID1AO144972MINT-7945693
    ASUNQ9NVM92MINT-7945693
    ATRXP461002MINT-7945693
    AURKAO149652MINT-7945693
    AURKBQ96GD42MINT-7945693
    BABAM1Q9NWV82MINT-7945693
    BAZ1AQ9NRL22MINT-7945693
    BCAS2O759342MINT-7945693
    BCL7CQ8WUZ02MINT-7945693
    BCLAF1Q9NYF82MINT-7945693
    BRD8Q9H0E92MINT-7945693
    BRIX1Q8TDN62MINT-7945693
    BTAF1O149812MINT-7945693
    BUB1O436832MINT-7945693
    BUB1BO605662MINT-7945693
    BUB3O436842MINT-7945693
    BZW1Q7L1Q62MINT-7945693
    BZW2Q9Y6E22MINT-7945693
    C22orf28Q9Y3I02MINT-7945693
    C7orf55-LUC7L2Q9Y3832MINT-7945693
    CAND1Q86VP62MINT-7945693
    CAPGP401212MINT-7945693
    CAPZA1P529072MINT-7945693
    CCNB1P146352MINT-7945693
    CCNT1O605632MINT-7945693
    CCT2P783712MINT-7945693
    CCT3P493682MINT-7945693
    CCT4P509912MINT-7945693
    CCT5P486432MINT-7945693
    CCT6AP402272MINT-7945693
    CCT7Q998322MINT-7945693
    CCT8P509902MINT-7945693
    CDC16Q130422MINT-7945693
    CDC23Q9UJX22MINT-7945693
    CDC27P302602MINT-7945693
    CDC5LQ994592MINT-7945693
    CDC73Q6P1J92MINT-7945693
    CDK1P064932MINT-7945693
    CDK12Q9NYV42MINT-7945693
    CDK3Q005262MINT-7945693
    CDK9P507502MINT-7945693
    CDKN2AIPQ9NXV62MINT-7945693
    CHD1LQ86WJ12MINT-7945693
    CHD3Q128732MINT-7945693
    CHD7Q9P2D12MINT-7945693
    CHD8Q9HCK82MINT-7945693
    CKAP5Q140082MINT-7945693
    CLP1Q929892MINT-7945693
    COPAP536212MINT-7945693
    COPB1P536182MINT-7945693
    COPB2P356062MINT-7945693
    COPG1Q9Y6782MINT-7945693
    COPG2Q9UBF22MINT-7945693
    COPS3Q9UNS22MINT-7945693
    COPS5Q929052MINT-7945693
    COPS6Q7L5N12MINT-7945693
    CPNE3O751312MINT-7945693
    CPSF1Q105702MINT-7945693
    CPSF2Q9P2I02MINT-7945693
    CPSF3Q9UKF62MINT-7945693
    CPSF4O956392MINT-7945693
    CPSF7Q8N6842MINT-7945693
    CSDAP169892MINT-7945693
    CSE1LP550602MINT-7945693
    CSKP412402MINT-7945693
    CSTF3Q129962MINT-7945693
    CTTNQ142472MINT-7945693
    CUL1Q136162MINT-7945693
    DCTN1Q142032MINT-7945693
    DCTN2Q135612MINT-7945693
    DDX17Q928412MINT-7945693
    DDX19AQ9NUU72MINT-7945693
    DDX19BQ9UMR22MINT-7945693
    DDX21Q9NR302MINT-7945693
    DDX23Q9BUQ82MINT-7945693
    DDX39AO001482MINT-7945693
    DDX39BQ138382MINT-7945693
    DDX3XO005712MINT-7945693
    DDX41Q9UJV92MINT-7945693
    DDX42Q86XP32MINT-7945693
    DDX46Q7L0142MINT-7945693
    DDX5P178442MINT-7945693
    DEPDC7Q96QD52MINT-7945693
    DFNA5O604432MINT-7945693
    DHX8Q145622MINT-7945693
    DHX9Q082112MINT-7945693
    DIAPH1O606102MINT-7945693
    DIAPH3Q9NSV42MINT-7945693
    DIDO1Q9BTC02MINT-7945693
    DMAP1Q9NPF52MINT-7945693
    DNAJA1P316892MINT-7945693
    DNAJC13O751652MINT-7945693
    DNM1LO004292MINT-7945693
    DNM2P505702MINT-7945693
    DOCK1Q141852MINT-7945693
    DOCK2Q926082MINT-7945693
    DPF2Q927852MINT-7945693
    DRG1Q9Y2952MINT-7945693
    DSPP159242MINT-7945693
    DYNC1H1Q142042MINT-7945693
    DYNC1LI2O432372MINT-7945693
    EBNA1BP2Q998482MINT-7945693
    EEF1A1P681042MINT-7945693
    EEFSECP577722MINT-7945693
    EFTUD2Q150292MINT-7945693
    EHD1Q9H4M92MINT-7945693
    EHD4Q9H2232MINT-7945693
    EIF2S1P051982MINT-7945693
    EIF2S2P200422MINT-7945693
    EIF2S3P410912MINT-7945693
    EIF3GO758212MINT-7945693
    EIF3HO153722MINT-7945693
    EIF3IQ133472MINT-7945693
    EIF3LQ9Y2622MINT-7945693
    EIF4A1P608422MINT-7945693
    EIF4A3P389192MINT-7945693
    EIF4G2P783442MINT-7945693
    EIF5BO608412MINT-7945693
    ENAHQ8N8S72MINT-7945693
    ENSG00000258947Q135092MINT-7945693
    ENSG00000266714Q96JP22MINT-7945693
    EPPK1P581072MINT-7945693
    EPS8L2Q9H6S32MINT-7945693
    ETF1P624952MINT-7945693
    ETV6P412122MINT-7945693
    EXOC1Q9NV702MINT-7945693
    EXOC2Q96KP12MINT-7945693
    EXOC3O606452MINT-7945693
    EXOC4Q96A652MINT-7945693
    EXOC5O004712MINT-7945693
    EXOC7Q9UPT52MINT-7945693
    EXOSC10Q017802MINT-7945693
    EXOSC6Q5RKV62MINT-7945693
    FAM105BQ96BN82MINT-7945693
    FAM129BQ96TA12MINT-7945693
    FASNP493272MINT-7945693
    FEN1P397482MINT-7945693
    FERMT1Q9BQL62MINT-7945693
    FHOD1Q9Y6132MINT-7945693
    FIP1L1Q6UN152MINT-7945693
    FUBP1Q96AE42MINT-7945693
    FUSP356372MINT-7945693
    FYTTD1Q96QD92MINT-7945693
    G3BP2Q9UN862MINT-7945693
    GATAD2AQ86YP42MINT-7945693
    GATAD2BQ8WXI92MINT-7945693
    GCN1L1Q926162MINT-7945693
    GEMIN4P576782MINT-7945693
    GNA14O958372MINT-7945693
    GSPT1P151702MINT-7945693
    GTF2IP783472MINT-7945693
    GTF3C1Q127892MINT-7945693
    GTF3C2Q8WUA42MINT-7945693
    GTF3C3Q9Y5Q92MINT-7945693
    GTF3C4Q9UKN82MINT-7945693
    GTPBP4Q9BZE42MINT-7945693
    GULP1Q9UBP92MINT-7945693
    HBS1LQ9Y4502MINT-7945693
    HDAC2Q927692MINT-7945693
    HDLBPQ003412MINT-7945693
    HELLSQ9NRZ92MINT-7945693
    HIP1RO751462MINT-7945693
    HIRAP541982MINT-7945693
    HLTFQ145272MINT-7945693
    HNRNPA0Q131512MINT-7945693
    HNRNPA1P096512MINT-7945693
    HNRNPA2B1P226262MINT-7945693
    HNRNPA3P519912MINT-7945693
    HNRNPABQ997292MINT-7945693
    HNRNPCP079102MINT-7945693
    HNRNPDQ141032MINT-7945693
    HNRNPFP525972MINT-7945693
    HNRNPH1P319432MINT-7945693
    HNRNPKP619782MINT-7945693
    HNRNPMP522722MINT-7945693
    HNRNPRO433902MINT-7945693
    HNRNPUQ008392MINT-7945693
    HSP90AA1P079002MINT-7945693
    HSP90AB1P082382MINT-7945693
    HSP90B1P146252MINT-7945693
    HSPA12AO433012MINT-7945693
    HSPA5P110212MINT-7945693
    HSPA8P111422MINT-7945693
    HSPB1P047922MINT-7945693
    HSPD1P108092MINT-7945693
    HTATSF1O437192MINT-7945693
    IKQ131232MINT-7945693
    ILF2Q129052MINT-7945693
    ILF3Q129062MINT-7945693
    ILKQ134182MINT-7945693
    INTS1Q8N2012MINT-7945693
    INTS12Q96CB82MINT-7945693
    INTS3Q68E012MINT-7945693
    IPO5O004102MINT-7945693
    IPO9Q96P702MINT-7945693
    IQGAP1P469402MINT-7945693
    KDM1AO603412MINT-7945693
    KHDRBS1Q076662MINT-7945693
    KIAA1279Q96EK52MINT-7945693
    KIF11P527322MINT-7945693
    KIF21AQ7Z4S62MINT-7945693
    KIF27Q86VH22MINT-7945693
    KIF2CQ996612MINT-7945693
    KIF4AO952392MINT-7945693
    KPNA1P522942MINT-7945693
    KPNA2P522922MINT-7945693
    KPNB1Q149742MINT-7945693
    KTI12Q96EK92MINT-7945693
    LDLRAP1Q5SW962MINT-7945693
    LIMS1P480592MINT-7945693
    LMNAP025452MINT-7945693
    LRRC40Q9H9A62MINT-7945693
    LRRC47Q8N1G42MINT-7945693
    LRWD1Q9UFC02MINT-7945693
    LUC7L2Q9Y3832MINT-7945693
    MAD1L1Q9Y6D92MINT-7945693
    MAGED2Q9UNF12MINT-7945693
    MAP2K2P365072MINT-7945693
    MAP2K3P467342MINT-7945693
    MAP2K7O147332MINT-7945693
    MATR3P432432MINT-7945693
    MBD3O959832MINT-7945693
    MDN1Q9NU222MINT-7945693
    MED4Q9NPJ62MINT-7945693
    METTL13Q8N6R02MINT-7945693
    MLKLQ8NB162MINT-7945693
    MLL2O146862MINT-7945693
    MORF4L1Q9UBU82MINT-7945693
    MORF4L2Q150142MINT-7945693
    MTA2O947762MINT-7945693
    MVPQ147642MINT-7945693
    MYH9P355792MINT-7945693
    MYO15BQ96JP22MINT-7945693
    NACC1Q96RE72MINT-7945693
    NCAPD2Q150212MINT-7945693
    NCAPGQ9BPX32MINT-7945693
    NCAPHQ150032MINT-7945693
    NCLP193382MINT-7945693
    NCOR1O753762MINT-7945693
    NCOR2Q9Y6182MINT-7945693
    NDC80O147772MINT-7945693
    NELFBQ8WX922MINT-7945693
    NELFCDQ8IXH72MINT-7945693
    NFICP086512MINT-7945693
    NIPBLQ6KC792MINT-7945693
    NOLC1Q149782MINT-7945693
    NONOQ152332MINT-7945693
    NR2C2P491162MINT-7945693
    NR2F2P244682MINT-7945693
    NR2F6P105882MINT-7945693
    NSFP464592MINT-7945693
    NSUN5Q96P112MINT-7945693
    NUDCQ9Y2662MINT-7945693
    NUF2Q9BZD42MINT-7945693
    NUP153P497902MINT-7945693
    NUP155O756942MINT-7945693
    NUP37Q8NFH42MINT-7945693
    OLA1Q9NTK52MINT-7945693
    ORC2Q134162MINT-7945693
    ORC3Q9UBD52MINT-7945693
    OXSR1O957472MINT-7945693
    PABPC1P119402MINT-7945693
    PABPN1Q86U422MINT-7945693
    PAK1Q131532MINT-7945693
    PAK4O960132MINT-7945693
    PARP4Q9UKK32MINT-7945693
    PARVAQ9NVD72MINT-7945693
    PARVBQ9HBI12MINT-7945693
    PAXIP1Q6ZW492MINT-7945693
    PBRM1Q86U862MINT-7945693
    PCBP2Q153662MINT-7945693
    PCF11O949132MINT-7945693
    PDCD6IPQ8WUM42MINT-7945693
    PDLIM7Q9NR122MINT-7945693
    PELP1Q8IZL82MINT-7945693
    PFKMP082372MINT-7945693
    PFKPQ018132MINT-7945693
    PHGDHO431752MINT-7945693
    PICALMQ134922MINT-7945693
    PIK3R4Q995702MINT-7945693
    PKN2Q165132MINT-7945693
    PKP3Q9Y4462MINT-7945693
    PLECQ151492MINT-7945693
    PLK1P533502MINT-7945693
    PLRG1O436602MINT-7945693
    PNNQ9H3072MINT-7945693
    POGZQ7Z3K32MINT-7945693
    POLD1P283402MINT-7945693
    POLEQ078642MINT-7945693
    POLR1CO151602MINT-7945693
    POLR2AP249282MINT-7945693
    POLR2EP193882MINT-7945693
    PRKAG1P546192MINT-7945693
    PRPF19Q9UMS42MINT-7945693
    PRPF40AO754002MINT-7945693
    PRPF6O949062MINT-7945693
    PRPF8Q6P2Q92MINT-7945693
    PSMC1P621912MINT-7945693
    PSMC2P359982MINT-7945693
    PSMC3P179802MINT-7945693
    PSMC4P436862MINT-7945693
    PSMC5P621952MINT-7945693
    PSMC6P623332MINT-7945693
    PSMD1Q994602MINT-7945693
    PSMD11O002312MINT-7945693
    PSMD12O002322MINT-7945693
    PSMD13Q9UNM62MINT-7945693
    PSMD2Q132002MINT-7945693
    PSMD3O432422MINT-7945693
    PTBP1P265992MINT-7945693
    PUF60Q9UHX12MINT-7945693
    PUM2Q8TB722MINT-7945693
    PURAQ005772MINT-7945693
    PWP1Q136102MINT-7945693
    RACGAP1Q9H0H52MINT-7945693
    RAD18Q9NS912MINT-7945693
    RAD21O602162MINT-7945693
    RAE1P784062MINT-7945693
    RALYQ9UKM92MINT-7945693
    RANBP2P497922MINT-7945693
    RANGAP1P460602MINT-7945693
    RBBP5Q152912MINT-7945693
    RBBP7Q165762MINT-7945693
    RBM10P981752MINT-7945693
    RBM14Q96PK62MINT-7945693
    RBM15Q96T372MINT-7945693
    RBM17Q96I252MINT-7945693
    RBM39Q144982MINT-7945693
    RBM4Q9BWF32MINT-7945693
    RBM45Q8IUH32MINT-7945693
    RBMXP381592MINT-7945693
    RCOR1Q9UKL02MINT-7945693
    RFC2P352502MINT-7945693
    RFC3P409382MINT-7945693
    RFC4P352492MINT-7945693
    RFC5P409372MINT-7945693
    RIF1Q5UIP02MINT-7945693
    RING1Q065872MINT-7945693
    RIOK1Q9BRS22MINT-7945693
    RNF2Q994962MINT-7945693
    ROCK2O751162MINT-7945693
    RPL12P300502MINT-7945693
    RPL13P263732MINT-7945693
    RPL19P840982MINT-7945693
    RPL22P352682MINT-7945693
    RPL23AP627502MINT-7945693
    RPL3P390232MINT-7945693
    RPL31P628992MINT-7945693
    RPL36Q9Y3U82MINT-7945693
    RPL4P365782MINT-7945693
    RPL7AP624242MINT-7945693
    RPL8P629172MINT-7945693
    RPLP0P053882MINT-7945693
    RPS14P622632MINT-7945693
    RPS18P622692MINT-7945693
    RPS19P390192MINT-7945693
    RPS25P628512MINT-7945693
    RPS3P233962MINT-7945693
    RPS6KA4O756762MINT-7945693
    RPS6KB2Q9UBS02MINT-7945693
    RUVBL2Q9Y2302MINT-7945693
    SART1O432902MINT-7945693
    SCYL2Q6P3W72MINT-7945693
    SEC23BQ154372MINT-7945693
    SEC31BQ9NQW12MINT-7945693
    SEH1LQ96EE32MINT-7945693
    SEPT7Q161812MINT-7945693
    SEPT9Q9UHD82MINT-7945693
    SETXQ7Z3332MINT-7945693
    SF3A1Q154592MINT-7945693
    SF3A3Q128742MINT-7945693
    SF3B1O755332MINT-7945693
    SF3B14Q9Y3B42MINT-7945693
    SF3B2Q134352MINT-7945693
    SF3B3Q153932MINT-7945693
    SF3B4Q154272MINT-7945693
    SFPQP232462MINT-7945693
    SHOC2Q9UQ132MINT-7945693
    SHROOM3Q8TF722MINT-7945693
    SMARCA2P515312MINT-7945693
    SMARCA5O602642MINT-7945693
    SMARCAD1Q9H4L72MINT-7945693
    SMARCC1Q929222MINT-7945693
    SMARCC2Q8TAQ22MINT-7945693
    SMARCD1Q96GM52MINT-7945693
    SMARCE1Q969G32MINT-7945693
    SMC2O953472MINT-7945693
    SMC4Q9NTJ32MINT-7945693
    SMCHD1A6NHR92MINT-7945693
    SMN1Q166372MINT-7945693
    SMN2Q166372MINT-7945693
    SND1Q7KZF42MINT-7945693
    SNRNP200O756432MINT-7945693
    SNRNP40Q96DI72MINT-7945693
    SNRNP70P086212MINT-7945693
    SNRPB2P085792MINT-7945693
    SNRPD3P623182MINT-7945693
    SNUPNO951492MINT-7945693
    SPATA5Q8NB902MINT-7945693
    SPATA5L1Q9BVQ72MINT-7945693
    SPTAN1Q138132MINT-7945693
    SPTBN1Q010822MINT-7945693
    SQSTM1Q135012MINT-7945693
    SRP19P091322MINT-7945693
    SRP54P610112MINT-7945693
    SRP68Q9UHB92MINT-7945693
    SRP72O760942MINT-7945693
    SRRM1Q8IYB32MINT-7945693
    SRRM2Q9UQ352MINT-7945693
    SRSF1Q079552MINT-7945693
    SRSF11Q055192MINT-7945693
    SRSF2Q011302MINT-7945693
    SRSF3P841032MINT-7945693
    SRSF5Q132432MINT-7945693
    SRSF6Q132472MINT-7945693
    SRSF7Q166292MINT-7945693
    STAG1Q8WVM72MINT-7945693
    SUGT1Q9Y2Z02MINT-7945693
    SUPV3L1Q8IYB82MINT-7945693
    SYMPKQ927972MINT-7945693
    SYNCRIPO605062MINT-7945693
    TAF12Q165142MINT-7945693
    TAF9Q165942MINT-7945693
    TARDBPQ131482MINT-7945693
    TBL1XR1Q9BZK72MINT-7945693
    TCP1P179872MINT-7945693
    THOC1Q96FV92MINT-7945693
    THOC2Q8NI272MINT-7945693
    THRAP3Q9Y2W12MINT-7945693
    TIAL1Q010852MINT-7945693
    TLN1Q9Y4902MINT-7945693
    TMPOP421662MINT-7945693
    TOX4O948422MINT-7945693
    TRAP1Q129312MINT-7945693
    TRIP12Q146692MINT-7945693
    TRIP13Q156452MINT-7945693
    TRUB1Q8WWH52MINT-7945693
    TSG101Q998162MINT-7945693
    TTKP339812MINT-7945693
    TUBA3EQ6PEY22MINT-7945693
    TUBA4AP683662MINT-7945693
    TUBBP074372MINT-7945693
    TUBB1Q9H4B72MINT-7945693
    TUBB3Q135092MINT-7945693
    TUBB4BP683712MINT-7945693
    TUBG1P232582MINT-7945693
    TUBGCP2Q9BSJ22MINT-7945693
    TUBGCP3Q96CW52MINT-7945693
    TUFMP494112MINT-7945693
    TWF1Q127922MINT-7945693
    U2AF1Q010812MINT-7945693
    U2AF2P263682MINT-7945693
    U2SURPO150422MINT-7945693
    UBA5Q9GZZ92MINT-7945693
    UBE2MP610812MINT-7945693
    UBE2NP610882MINT-7945693
    UBE2Q1Q7Z7E82MINT-7945693
    UBL4AP114412MINT-7945693
    UCHL5Q9Y5K52MINT-7945693
    UNC45AQ9H3U12MINT-7945693
    UPF2Q9HAU52MINT-7945693
    USP39Q53GS92MINT-7945693
    USP48Q86UV52MINT-7945693
    VASPP505522MINT-7945693
    VIMP086702MINT-7945693
    VPS33BQ9H2672MINT-7945693
    VRK1Q999862MINT-7945693
    WAPALQ7Z5K22MINT-7945693
    WDR18Q9BV382MINT-7945693
    WDR33Q9C0J82MINT-7945693
    WDR5P619642MINT-7945693
    WIZO957852MINT-7945693
    XPO6Q96QU82MINT-7945693
    XRCC6P129562MINT-7945693
    XRN2Q9H0D62MINT-7945693
    YTHDC2Q9H6S02MINT-7945693
    YY1P254902MINT-7945693
    ZNF326Q5BKZ12MINT-7945693
    ZNF638Q149662MINT-7945693
    BARD1ENSP000002609474STRING: ENSP00000260947
    CDC25AENSP000003037064STRING: ENSP00000303706
    CDK2ENSP000002669704STRING: ENSP00000266970
    CDK4ENSP000002579044STRING: ENSP00000257904
    CTBP1ENSP000002909214STRING: ENSP00000290921
    FAM175AENSP000003698574STRING: ENSP00000369857
    MLH3ENSP000003480204STRING: ENSP00000348020
    MND1ENSP000002404884STRING: ENSP00000240488
    MSH4ENSP000002631874STRING: ENSP00000263187
    RAD51CENSP000003367014STRING: ENSP00000336701
    RFWD2ENSP000003566414STRING: ENSP00000356641
    RPA3ENSP000002231294STRING: ENSP00000223129
    SPO11ENSP000003603104STRING: ENSP00000360310
    TEX15ENSP000002562464STRING: ENSP00000256246
    TFDP1ENSP000003645194STRING: ENSP00000364519
    TOP3AENSP000003216364STRING: ENSP00000321636
    TTC5ENSP000002588214STRING: ENSP00000258821
    UIMC1ENSP000003664344STRING: ENSP00000366434
    XRCC4ENSP000003420114STRING: ENSP00000342011
    PSMC3IPENSP000003773844STRING: ENSP00000377384
    TAOK2ENSP000003100944STRING: ENSP00000310094
    TFDP2ENSP000003096224STRING: ENSP00000309622
    CLK2ENSP000003548564STRING: ENSP00000354856
    PARP1ENSP000003557594STRING: ENSP00000355759
    RNF20ENSP000003737724STRING: ENSP00000373772
    RNF40ENSP000003256774STRING: ENSP00000325677
    TERF2ENSP000002549424STRING: ENSP00000254942
    MAP3K7ENSP000003583354STRING: ENSP00000358335
    RRM1ENSP000003007384STRING: ENSP00000300738
    SKP2ENSP000002742554STRING: ENSP00000274255
    About this table

    Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000077DNA damage checkpoint ----
    GO:0000723telomere maintenance IEA--
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0001666response to hypoxia IEA--


    ATM for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATM for compounds           About GeneDecksing

    EMD Millipore small molecules for ATM:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ATM available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KU 55933Potent and selective ATM kinase inhibitor[587871-26-9]
    KU 60019Potent ATM kinase inhibitor[925701-46-8]
    CGK 733Selective inhibitor of ATR and ATM kinases[905973-89-9]
    MirinMRN-ATM pathway inhibitor--

    2 HMDB Compounds for ATM    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    10/46 Novoseek chemical compound relationships for ATM gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 58.6 27 11114307 (1), 17507690 (1), 9442910 (1), 12513844 (1) (see all 24)
    wortmannin 56.5 24 10771089 (3), 15173573 (2), 9808536 (2), 15709017 (1) (see all 14)
    neocarzinostatin 50.7 3 15345673 (1), 9244351 (1), 9050866 (1)
    caffeine 50.2 33 10485486 (4), 16479016 (2), 11864911 (2), 10744722 (2) (see all 19)
    aphidicolin 46.5 5 11279043 (1), 11114888 (1)
    hydroxyurea 43.4 6 11689451 (1), 16293623 (1), 11114888 (1)
    topotecan 35.2 11 18802408 (3), 16426422 (3), 16760673 (2), 16184611 (1)
    camptothecin 32.1 15 20304914 (5), 15699047 (2), 16158199 (1), 10327072 (1)
    mitoxantrone 30.9 10 16760673 (4), 18802408 (3), 16184611 (1), 19411853 (1)
    ly294002 30.4 8 10771089 (3), 18589211 (1), 19038232 (1)

    Search CenterWatch for drugs/clinical trials and news about ATM 

    Transcripts
    for ATM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATM gene (3 alternative transcripts): 
    NM_000051.3  NM_138292.3  NM_138293.1  

    Unigene Cluster for ATM:

    Ataxia telangiectasia mutated
    Hs.367437  [show with all ESTs]
    Unigene Representative Sequence: NM_000051
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000527805(uc009yxs.1) ENST00000527891 ENST00000532931 ENST00000530958
    ENST00000452508(uc001pke.2) ENST00000526567(uc001pkc.1) ENST00000525012
    ENST00000533526 ENST00000532637 ENST00000533470 ENST00000419286 ENST00000531525(uc001pkf.3)
    ENST00000533733(uc001pkd.4) ENST00000524792 ENST00000531957 ENST00000533690(uc009yxt.1 uc001pkg.1)
    ENST00000534625 ENST00000529588

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ATM
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATM
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ATM (see all 15):
    hsa-miR-34c-3p hsa-miR-203 hsa-miR-18a hsa-miR-181c hsa-miR-516b hsa-miR-181a hsa-miR-519c-3p hsa-miR-181d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATM (see all 7)
    OriGene shRNA RFP: ATM
    OriGene siRNA: ATM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATM
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATM (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATM (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ATM (NM_000051)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATM 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATM
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATM

    Additional cDNA sequence: 

    AF035326.1 AF035327.1 AF035328.1 AK093586.1 AK299843.1 BC007023.2 BC022306.1 BC061584.1 
    BC152385.1 BC152389.1 BT006764.1 BX640631.1 CR749436.1 HM437232.1 U33841.1 U67093.1 
    X91196.1 Y08455.1 

    21 DOTS entries:

    DT.102832095  DT.100750015  DT.91916232  DT.91717023  DT.101977439  DT.99971554  DT.121643246  DT.451837 
    DT.100750014  DT.99928041  DT.120760397  DT.65284599  DT.97778369  DT.120760409  DT.120760428  DT.40122485 
    DT.75194025  DT.91664691  DT.97825561  DT.120760412  DT.99957611 

    24/200 AceView cDNA sequences (see all 200):

    AA149504 CD721939 BM671057 BC007023 BQ005085 AA632114 BX096702 AK093586 
    AA421745 AI523344 BM800438 AA814352 R26821 AL706720 AI559463 AA782580 
    BX642224 AA962359 AV705298 AI479273 BF981497 U26455 BM451149 AA149636 

    GeneLoc Exon Structure


    Expression
    for ATM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ATM expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatogonial Stem CellsGerm Cells, Male Gametocytes
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

    See ATM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATM

    SOURCE GeneReport for Unigene cluster: Hs.367437

    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
    Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus,
    testis, ovary, small intestine, colon and leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including ATM (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATM
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATM
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATM
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATM
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM

    Orthologs
    for ATM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATM gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ATM1 ataxia telangiectasia mutated 72.23(n)
    69.69(a)    		   395401  NM_001162400.1  NP_001155872.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 87(a)
    		 1 ↔ 1
    		 5(124957040-124966704)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ATM2 ataxia telangiectasia mutated 75.21(n)    AF174488.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.286552 Danio rerio partial mRNA for ataxia telangiectasia more 73.34(n)    AJ605775.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG65353 cell cycle checkpoint protein kinase 27(a)     --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATM6
    		 serine/threonine-protein kinase
    		 16(a)
    		 1 ↔ 1
    		 3(17797334-17828591)
    rice
    (Oryza sativa)    		 Liliopsida Os.170832 Oryza sativa (japonica cultivar-group) AtATM like protein more 75(n)    NM_183488.1 


    ENSEMBL Gene Tree for ATM (if available)
    TreeFam Gene Tree for ATM (if available) 

    Paralogs
    for ATM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATM gene
    2 SIMAP similar genes for ATM using alignment to 16 protein entries:     ATM_HUMAN (see all proteins):
    DKFZp781A0353    MTOR

    ATM for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATM
    PGOHUM00000233233


    Genomic Variants
    for ATM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2630 NCBI SNPs in ATM are shown (see all 2630)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs289421031,2
    		Cpathogenic129242677(+) AGAATA/GTGGAA 2 Y C mis1 ese30--------
    rs289049211,2
    		Cpathogenic129248463(+) GGAAGG/TAGGTC 2 G V mis10--------
    rs558612491,2
    		C,Fpathogenic129349859(+) TGATTA/C/TGAGAT 3 R * syn1 stg12CSA NA 4414
    rs49879841,2
    		C,Funtested104077327(+) TTTAAA/-TTTCT 1 -- int11Minor allele frequency- -:0.43NS 170
    rs30928571,2
    		C,F,H,other129305100(+) TAAGAA/GTGGCC 2 M V mis126Minor allele frequency- G:0.01NA MN NS EA 7154
    rs18000541,2
    		C,F,other129349816(+) AGATTC/GCAAAC 2 S C mis1 ese310Minor allele frequency- G:0.01MN NA EU 6351
    rs49878741,2
    		C,F,H,--104017927(+) CAAGAC/GAAATG 1 -- us2k16Minor allele frequency- G:0.02NS EA NA 708
    rs49878751,2
    		C,F,H,--104018238(+) TAAGGC/TAATTA 1 -- us2k113Minor allele frequency- T:0.03NS EA CSA WA 1180
    rs49878761,2
    		C,F,H,--104018261(+) TTTTCG/TCTGAT 1 -- us2k132Minor allele frequency- T:0.07NS NA EA WA 3176
    rs49878781,2
    		C,F,H,--104018626(+) CCCTCG/TGGCTT 1 -- us2k16Minor allele frequency- T:0.02NS EA WA 670

    HapMap Linkage Disequilibrium report for ATM (108093211 - 108239829 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ATM: --
    Human Gene Mutation Database (HGMD): ATM

    Locus Specific Mutation Databases (LSDB): ATM

    5/6 SABiosciences Cancer Mutation PCR Assays for ATM (see all 6):
    Cosmic IdAA Change
    20404p.R2443Q
    21826p.F858L
    21624p.R3047*
    12951p.Q2442P
    21642p.R3008C
    5 SABiosciences Cancer Mutation PCR Arrays containing ATM:
    Lymphoid Neoplasms
    Lung and Colon Cancers (Expanded Panel) 384HT   
    Pathway
    Cancer Comprehensive Panel 384HT
    Tumor Suppressor Panel 384HT
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATM
    DNA2.0 Custom Variant and Variant Library Synthesis for ATM

    Disorders / Diseases
    for ATM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATM for disorders           About GeneDecksing

    OMIM gene information: 607585   
    OMIM disorders: 208900  114480  
    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
  • Defects in ATM are the cause of ataxia telangiectasia (AT) [MIM:208900]; also known as Louis-Bar syndrome,
    • which includes four complementation groups: A, C, D and E. This rare recessive disorder is characterized by
    progressive cerebellar ataxia, dilation of the blood vessels in the conjunctiva and eyeballs, immunodeficiency, growth
    retardation and sexual immaturity. AT patients have a strong predisposition to cancer; about 30% of patients develop
    tumors, particularly lymphomas and leukemias. Cells from affected individuals are highly sensitive to damage by
    ionizing radiation and resistant to inhibition of DNA synthesis following irradiation
  • Note=Defects in ATM contribute to T-cell acute lymphoblastic leukemia (TALL) and T-prolymphocytic leukemia
    • (TPLL). TPLL is characterized by a high white blood cell count, with a predominance of prolymphocytes, marked
    splenomegaly, lymphadenopathy, skin lesions and serous effusion. The clinical course is highly aggressive, with poor
    response to chemotherapy and short survival time. TPLL occurs both in adults as a sporadic disease and in younger AT
    patients
  • Note=Defects in ATM contribute to B-cell non-Hodgkin lymphomas (BNHL), including mantle cell lymphoma (MCL)
  • Note=Defects in ATM contribute to B-cell chronic lymphocytic leukemia (BCLL). BCLL is the commonest form of
    • leukemia in the elderly. It is characterized by the accumulation of mature CD5+ B-lymphocytes, lymphadenopathy,
    immunodeficiency and bone marrow failure

    20/140 diseases for ATM (see all 140):    About MalaCards
    ataxia telangiectasia    ataxia    lymphoma, b-cell non-hodgkin, somatic    li-fraumeni syndrome
    cll/sll    nijmegen breakage syndrome-like disorder    nijmegen breakage syndrome    marginal zone b-cell lymphoma
    t-cell prolymphocytic leukemia, sporadic    xeroderma pigmentosum, group a    b-cell non-hodgkin lymphoma    diffuse large b-cell lymphoma
    t-cell prolymphocytic leukemia    human t-cell leukemia virus type 1    spinal cord disease    prolymphocytic leukemia
    non-hodgkin lymphoma    b-cell lymphomas    asphyxiating thoracic dystrophy    xeroderma pigmentosum

    10 diseases from the University of Copenhagen DISEASES database for ATM:
    Ataxia telangiectasia     Nijmegen breakage syndrome     Breast cancer     Genetic disorder
    Telangiectasis     Cerebellar ataxia     Leukemia     Lymphoma
    Fanconi's anemia     Seckel syndrome

    10/89 Novoseek disease relationships for ATM gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 98.2 473 9622061 (3), 16799570 (3), 7545545 (2), 8843194 (2) (see all 99)
    nijmegen breakage syndrome 87.5 20 15024084 (1), 17507690 (1), 18215521 (1), 18723444 (1) (see all 17)
    cerebellar degeneration 77.4 4 9054948 (1), 9770541 (1), 8968760 (1), 11443540 (1)
    telangiectasia 70.7 13 12882767 (4), 18502988 (2), 19799357 (1), 12513844 (1) (see all 8)
    genetic disorder 69.8 40 10549596 (2), 7545545 (1), 9535798 (1), 10567403 (1) (see all 39)
    lymphocytic leukemia chronic b-cell 65.4 16 11468183 (2), 9892178 (1), 9788599 (1), 10738255 (1) (see all 14)
    cancer 63.5 122 12513844 (4), 18565893 (4), 12195425 (3), 15390180 (3) (see all 83)
    leukemia prolymphocytic 62.7 8 9573030 (2), 10738255 (1), 12149228 (1), 18073348 (1) (see all 7)
    bilateral breast cancer 60.9 10 19153073 (3), 12673797 (1), 14562025 (1), 15756685 (1) (see all 5)
    fanconis anemia 59.3 1 11733219 (1)

    GeneTests: ATM
    Ataxia-Telangiectasia

    Genetic Association Database (GAD): ATM
    Human Genome Epidemiology (HuGE) Navigator: ATM (170 documents)
    Tumor Gene Database (TGDB): ATM

    Export disorders for ATM gene to outside databases

    Publications
    for ATM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATM gene, integrated from 9 sources (see all 1345):
    (articles sorted by number of sources associating them with ATM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations associated with variant phenotypes in ataxia- telangiectasia. (PubMed id 8755918)1, 2, 4 McConville C.M.... Taylor A.M.R. (1996)
    2. ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects. (PubMed id 11849780)1, 4, 9 Iannuzzi C.M....Rosenstein B.S. (2002)
    3. Inactivation of the ATM gene in T-cell prolymphocytic leukemias. (PubMed id 9573030)1, 2, 9 Stoppa-Lyonnet D.... Stern M.-H. (1998)
    4. Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene. (PubMed id 9199932)1, 2, 9 Platzer M.... Rosenthal A. (1997)
    5. The product of the ATM gene is a 370-kDa nuclear phosphoprotein. (PubMed id 8969240)1, 2, 9 Chen G. and Lee E.Y.-H.P. (1996)
    6. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. (PubMed id 17923702)1, 2, 9 Sun Y....Price B.D. (2007)
    7. Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity. (PubMed id 10873394)1, 2, 9 Becker-Catania S.G.... Gatti R.A. (2000)
    8. Mantle cell lymphoma is characterized by inactivation of the ATM gene. (PubMed id 10706620)1, 2, 9 Schaffner C.... Lichter P. (2000)
    9. Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. (PubMed id 10397742)1, 2, 9 Schaffner C.... Lichter P. (1999)
    10. Genotype-phenotype relationships in ataxia-telangiectasia and variants. (PubMed id 9497252)1, 2, 9 Gilad S.... Bar-Shira A. (1998)

    External Searches for ATM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ATM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 472 HGNC: 795 AceView: ATM Ensembl:ENSG00000149311 euGenes: HUgn472
    ECgene: ATM Kegg: 472 H-InvDB: ATM

    Other Databases showing ATM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATM Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ATM
    NIEHS-SNPshttp://egp.gs.washington.edu/data/atm/
    Wikipedia http://en.wikipedia.org/wiki/Ataxia_telangiectasia_mutated

    Intellectual Property
    for ATM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATM gene:
    Search GeneIP for patents involving ATM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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