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ATM Gene

protein-coding   GIFtS: 77
GCID: GC11P108093

Ataxia Telangiectasia Mutated

(Previous names: ataxia telangiectasia mutated (includes complementation...)
(Previous symbols: ATA, ATDC, ATC, ATD)
  See ATM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ataxia Telangiectasia Mutated1 2 3     Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C And D)1
ATA1 2 5     Homolog (S. Cerevisiae)1
ATC1 2     Telomere Maintenance 11
ATD1 2     ATE2
ATDC1 2     TELO12
TEL11 2     AT Mutated2
A-T Mutated2 3     Serine-Protein Kinase ATM2
EC 2.7.11.13 8     TEL1, Telomere Maintenance 1, Homolog2
AT12 5     

External Ids:    HGNC: 7951   Entrez Gene: 4722   Ensembl: ENSG000001493117   OMIM: 6075855   UniProtKB: Q133153   

Export aliases for ATM gene to outside databases

Previous GC identifers: GC11P110302 GC11P109450 GC11P108127 GC11P107631 GC11P107599 GC11P104019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATM Gene:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle
checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream
proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17
and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master
controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for
genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive
disorder. (provided by RefSeq, Aug 2010)

GeneCards Summary for ATM Gene:
ATM (ataxia telangiectasia mutated) is a protein-coding gene. Diseases associated with ATM include b-cell chronic lymphocytic leukemia, and chromosome 11q deletion. GO annotations related to this gene include protein serine/threonine kinase activity and protein complex binding.

UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
Function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),
apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage
sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant
H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in
pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to
enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual
B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by
mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to
the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle
control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2,
CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle
and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role
in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in
response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation.
Phosphorylates ATF2 which stimulates its function in DNA damage response

summary for ATM Gene:
ATM (Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related) are closely related
kinases that are activated by DNA damage. These serine-threonine protein kinases are part of the
phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding
proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by
phosphorylating a number of key proteins. Once activated, the checkpoint leads to cell cycle arrest and
either DNA repair or apoptosis. ATM is activated by double stranded breaks and phosphorylates Chk2, whilst
ATR is activated by single strand breaks and phosphorylates Chk1.

Gene Wiki entry for ATM (Ataxia telangiectasia mutated) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATM gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ATM promoter sequence
   Search Chromatin IP Primers for ATM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22-q23

ATM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATM gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P108093:  view genomic region     (about GC identifiers)

Start:
108,093,211 bp from pter      End:
108,239,829 bp from pter
Size:
146,619 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315 (See protein sequence)
Recommended Name: Serine-protein kinase ATM  
Size: 3056 amino acids; 350687 Da
Subunit: Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers
rendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the
BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and
the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell
cycle and within subnuclear domains. Interacts with RAD17; DNA damage promotes the association. Interacts with
EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, KAT8, KAT5, NABP2,
ATMIN and CEP164. Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity).
Interacts with TELO2 and TTI1. Interacts with DDX1
Sequence caution: Sequence=AAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA86520.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI37170.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI37170.1; Type=Miscellaneous
discrepancy; Note=Probable cloning artifact; Sequence=EAW67111.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RNX5 O15429 Q12758 Q16551 Q93007 Q9NP02 Q9UCX7

Explore the universe of human proteins at neXtProt for ATM: NX_Q13315

Explore proteomics data for ATM at MOPED

Post-translational modifications: 

  • Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA
    damage-mediated activation of the kinase1
  • Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and
    subsequent autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP601
  • Ubiquitination2 at Lys215, Lys1109, Lys1114, Lys1126, Lys1323, Lys1572, Lys1994, Lys2025, Lys2148, Lys2160,
                                 Lys2789, Lys2848
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATM (Q13315) (see all 6)
     TYKVVPL  EPDSLYG  EGVFRRC  DDLRQDA 


    See ATM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000042.3  
    ENSEMBL proteins: 
     ENSP00000435747   ENSP00000433955   ENSP00000432318   ENSP00000388058   ENSP00000469471  
     ENSP00000434327   ENSP00000435524   ENSP00000278616  
    Reactome Protein details: Q13315

    ATM Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ATM Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ATM
    GenScript Custom Purified and Recombinant Proteins Services for ATM
    Novus Biologicals ATM Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATM

     
    Search eBioscience for Proteins for ATM 

     
    antibodies-online proteins for ATM (4 products) 

     
    antibodies-online peptides for ATM

    ATM Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATM
    R&D Systems Antibodies for ATM
    Cell Signaling Technology (CST) Antibodies for ATM 
    OriGene Antibodies for ATM
    OriGene Custom Antibody Services for ATM
    Novus Biologicals ATM Antibodies
    Abcam antibodies for ATM
    Cloud-Clone Corp. Antibodies for ATM
    ThermoFisher Antibody for ATM
    antibodies-online antibodies for ATM (230 products) 

    ATM Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATM
    R&D Systems ELISAs for ATM
    GenScript Custom Assay Services for ATM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATM
    Cloud-Clone Corp. CLIAs for ATM
    Search eBioscience for ELISAs for ATM 
    antibodies-online kits for ATM (33 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: ataxia telangiectasia mutated
    Other PIKK family kinases

    Selected InterPro protein domains (see all 8):
     IPR011009 Kinase-like_dom
     IPR021668 TAN
     IPR014009 PIK_FAT
     IPR000403 PI3/4_kinase_cat_dom
     IPR003151 PIK-rel_kinase_FAT

    Graphical View of Domain Structure for InterPro Entry Q13315

    ProtoNet protein and cluster: Q13315

    2 Blocks protein domains:
    IPB000403 Phosphatidylinositol 3- and 4-kinase
    IPB003151 PIK-related kinase


    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
    Domain: The FATC domain is required for interaction with KAT5
    Similarity: Belongs to the PI3/PI4-kinase family. ATM subfamily
    Similarity: Contains 1 FAT domain
    Similarity: Contains 1 FATC domain
    Similarity: Contains 1 PI3K/PI4K domain


    Find genes that share domains with ATM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATM_HUMAN, Q13315
    Function: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs),
    apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage
    sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant
    H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in
    pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to
    enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual
    B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by
    mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to
    the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle
    control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2,
    CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle
    and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role
    in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in
    response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation.
    Phosphorylates ATF2 which stimulates its function in DNA damage response
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by wortmannin
    Induction: By ionizing radiation

         Genatlas biochemistry entry for ATM:
    ataxia telangiectasia,mutated,protein kinase,involved in cellular responses to ionizing radiation (IR)-induced DNA
    damage such as double strand breaks and cell cycle control through phosphorylation of BRCA1,homologous to cell
    cycle G2 checkpoint gene yeast MEC1 and related TEL1,RAD3 (S pombe),Drosophila mei-41,also homologous to yeast
    TOR1,TOR2, activating TP53 in association with 14.3.3 proteins YWHA*,and leading to cell cycle arrest and
    apoptosis,also activating ABL1 (cABL) and TP73 in a mismatch repair dependent apoptosis pathway,interacting with
    beta adaptin for the axonal transport and vesicle trafficking in the central nervous system,mutated (somatic
    mutation) in B cell chronic lymphocytic leukemia,also mutated in ataxia telangiectasia (see AT),but not mutated
    in childhood T-ALL,deleted in mantle cell lymphoma (see also TSG11F)

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA11375976
    GO:0004677DNA-dependent protein kinase activity IDA15790808
    GO:0005488binding ----
         
    Find genes that share ontologies with ATM           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ATM:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased apoptosis  PARP inhibitor sensitization 

         11 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Atm):
     behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  immune system  mortality/aging  nervous system  reproductive system 
     tumorigenesis 

    Find genes that share phenotypes with ATM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ATM: Atmtm1Pmc Atmtm1Awb Atmtm1Led Atmtm1Bal Atmtm1Fwa Atmtm1Mfl

       genOway: Develop your customized and physiologically relevant rodent model for ATM

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATM:
    hsa-mir-374a-5p (MIRT005573), hsa-mir-19b-3p (MIRT031122), hsa-mir-18a-5p (MIRT006118), hsa-mir-100-5p (MIRT005913), hsa-mir-101-5p (MIRT005559), hsa-mir-3144-3p (MIRT052661), hsa-mir-421 (MIRT003215), hsa-mir-101-3p (MIRT005560), hsa-mir-181a-5p (MIRT005576), hsa-mir-92a-3p (MIRT049505)

    Block miRNA regulation of human, mouse, rat ATM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATM (see all 15):
    hsa-miR-34c-3p hsa-miR-203 hsa-miR-18a hsa-miR-181c hsa-miR-516b hsa-miR-181a hsa-miR-519c-3p hsa-miR-181d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATM
    Predesigned siRNA for gene silencing in human, mouse, rat ATM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATM

    Clone
    Products:
         
    OriGene clones in human, mouse for ATM (see all 9)
    OriGene ORF clones in mouse, rat for ATM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATM (NM_000051)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATM
    Addgene plasmids for ATM 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATM
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12375) for ATM 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATM_HUMAN, Q13315: Nucleus. Cytoplasmic vesicle. Note=Primarily nuclear. Found also in endocytic vesicles in
    association with beta-adaptin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3
    cytoskeleton2
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781colocalizes with chromosome, telomeric region IDA15149599
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005819spindle IEA--

    Find genes that share ontologies with ATM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATM About   (see all 51)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    3CDK-mediated phosphorylation and removal of Cdc6
    Stabilization of p530.92
    p53-Independent DNA Damage Response0.91
    p53-Dependent G1 DNA Damage Response0.92
    Autodegradation of the E3 ubiquitin ligase COP10.91
    p53-Dependent G1/S DNA damage checkpoint0.92
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A0.91
    Cell Cycle Checkpoints0.58
    4Homologous Recombination Repair
    Homologous Recombination Repair0.70
    Recruitment of repair and signaling proteins to double-strand breaks0.00
    Double-Strand Break Repair0.70
    Homologous recombination repair of replication-independent double-strand breaks0.00
    ATM mediated response to DNA double-strand break0.31
    ATM mediated phosphorylation of repair proteins0.00
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    p53 Mediated Apoptosis0.84
    Cellular Apoptosis Pathway0.85
    Telomerase Components in Cell Signaling0.72


    Find genes that share SuperPaths with ATM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ATM (see all 17)
        Telomerase Components in Cell Signaling
    BRCA1 Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    2 Cell Signaling Technology (CST) Pathways for ATM
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 Tocris Bioscience Pathway for ATM
        Apoptosis Pathway

    5 GeneGo (Thomson Reuters) Pathways for ATM
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription P53 signaling pathway
    DNA damage DNA-damage-induced responses
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for ATM (see all 19)
        Cell cycle
    DNA damage response
    G1 to S cell cycle control
    DNA damage response (only ATM dependent)
    Homologous recombination

    Selected Reactome Pathways for ATM (see all 11)
        ATM mediated response to DNA double-strand break
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    Regulation of HSF1-mediated heat shock response
    Regulation of the Fanconi anemia pathway
    Stabilization of p53

    1 PharmGKB Pathway for ATM
        Metformin Pathway, Pharmacodynamic

    Selected Kegg Pathways  (Kegg details for ATM) (see all 8):
        NF-kappa B signaling pathway
    FoxO signaling pathway
    Cell cycle
    p53 signaling pathway
    Apoptosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATM (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ATM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATM (Q133151, 2, 3 ENSP000002786164) via UniProtKB, MINT, STRING, and/or I2D (see all 854) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206481Q146761, 3, ENSP000003730604EBI-495465,EBI-495644 I2D: score=4 STRING: ENSP00000373060
    ENSG00000237095Q146761, 3, ENSP000004091674EBI-495465,EBI-495644 I2D: score=4 STRING: ENSP00000409167
    MDC1Q146761, 3, ENSP000003655884EBI-495465,EBI-495644 I2D: score=4 STRING: ENSP00000365588
    ATMINO433131, 2, 3, ENSP000002995754EBI-495465,EBI-7422202 MINT-4979579 MINT-4979598 MINT-4979635 MINT-4979556 MINT-4979615 I2D: score=1 STRING: ENSP00000299575
    ENSG00000224587Q146761, 3EBI-495465,EBI-495644 I2D: score=4 
    ENSG00000225589Q146761, 3EBI-495465,EBI-495644 I2D: score=4 
    ENSG00000228575Q146761, 3EBI-495465,EBI-495644 I2D: score=4 
    ENSG00000231135Q146761, 3EBI-495465,EBI-495644 I2D: score=4 
    ENSG00000234012Q146761, 3EBI-495465,EBI-495644 I2D: score=4 
    H2AFXP161042, 3, ENSP000003643104MINT-2843419 I2D: score=6 STRING: ENSP00000364310
    TP53P046372, 3, ENSP000002693054MINT-49767 I2D: score=6 STRING: ENSP00000269305
    PRKDCP785272, 3, ENSP000003134204MINT-7945693 I2D: score=3 STRING: ENSP00000313420
    PPP1CAP621362, 3, ENSP000003260314MINT-7945693 I2D: score=2 STRING: ENSP00000326031
    TDP1Q9NUW82, 3, ENSP000003373534MINT-7543535 I2D: score=2 STRING: ENSP00000337353
    BLMP541322, 3, ENSP000003472324MINT-7945693 I2D: score=1 STRING: ENSP00000347232
    CHD4Q148392, 3, ENSP000003495084MINT-7945693 I2D: score=1 STRING: ENSP00000349508
    DDX1Q924992, 3, ENSP000002330844MINT-7945693 I2D: score=1 STRING: ENSP00000233084
    FANCIQ9NVI12, 3, ENSP000003108424MINT-7945693 I2D: score=1 STRING: ENSP00000310842
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 I2D: score=1 STRING: ENSP00000362649
    MLH1P406922, 3, ENSP000002317904MINT-7945693 I2D: score=1 STRING: ENSP00000231790
    MSH6P527012, 3, ENSP000002344204MINT-7945693 I2D: score=1 STRING: ENSP00000234420
    SMARCB1Q128242, 3, ENSP000002631214MINT-7945693 I2D: score=1 STRING: ENSP00000263121
    SMC3Q9UQE72, 3, ENSP000003547204MINT-7945693 I2D: score=1 STRING: ENSP00000354720
    UPF1Q929002, 3MINT-7945693 I2D: score=2 
    AP3B1O002032, 3MINT-7945693 I2D: score=1 
    IKBKGQ9Y6K91, 2, 3, ENSP000003586224EBI-495465,EBI-81279 MINT-6978609 MINT-6978672 MINT-6978624 MINT-6978648 I2D: score=2 STRING: ENSP00000358622
    NBNO609342, 3, ENSP000002654334MINT-7945693 I2D: score=5 STRING: ENSP00000265433
    CHEK2O960172, 3, ENSP000003720234MINT-8052875 I2D: score=5 STRING: ENSP00000372023
    TERF1P542741, 3, ENSP000002766034EBI-495465,EBI-710997 I2D: score=4 STRING: ENSP00000276603
    TELO2Q9Y4R81, 3, ENSP000002623194EBI-495465,EBI-1043674 I2D: score=5 STRING: ENSP00000262319
    SMC1AQ146832, 3, ENSP000003234214MINT-7945693 I2D: score=4 STRING: ENSP00000323421
    TTI1O431561, 3, ENSP000003625464EBI-495465,EBI-1055680 I2D: score=1 STRING: ENSP00000362546
    AP1B1Q105672, 3, ENSP000003501994MINT-7945693 I2D: score=6 STRING: ENSP00000350199
    ATRQ135352, 3, ENSP000003437414MINT-7945693 I2D: score=1 STRING: ENSP00000343741
    CHEK1O147572, 3, ENSP000002789164MINT-7945693 I2D: score=3 STRING: ENSP00000278916
    MRE11AP499592, 3, ENSP000003258634MINT-7945693 I2D: score=4 STRING: ENSP00000325863
    NABP2Q9BQ151, 3, ENSP000002670234EBI-495465,EBI-2120336 I2D: score=1 STRING: ENSP00000267023
    AATFQ9NY611, 3, ENSP000002254024EBI-495465,EBI-372428 I2D: score=3 STRING: ENSP00000225402
    MSH2P432462, 3, ENSP000002331464MINT-7945693 I2D: score=1 STRING: ENSP00000233146
    RAD50Q928782, 3, ENSP000002653354MINT-7945693 I2D: score=1 STRING: ENSP00000265335
    BRCA1P383983, ENSP000003502834I2D: score=5 STRING: ENSP00000350283
    RHEBQ153823, ENSP000002621874I2D: score=5 STRING: ENSP00000262187
    ABL1P005193, ENSP000003614234I2D: score=4 STRING: ENSP00000361423
    EIF4EBP1Q135413, ENSP000003406914I2D: score=4 STRING: ENSP00000340691
    RAD17O759433, ENSP000003701514I2D: score=4 STRING: ENSP00000370151
    E2F1Q010943, ENSP000003455714I2D: score=3 STRING: ENSP00000345571
    EEF1E1O433243, ENSP000003690384I2D: score=3 STRING: ENSP00000369038
    RBBP8Q997083, ENSP000003230504I2D: score=3 STRING: ENSP00000323050
    AP3B2Q133673, ENSP000002617224I2D: score=2 STRING: ENSP00000261722
    E4F1Q66K893, ENSP000003017274I2D: score=2 STRING: ENSP00000301727
    LIG4P499173, ENSP000003493934I2D: score=2 STRING: ENSP00000349393
    MDM4O151513, ENSP000003561504I2D: score=2 STRING: ENSP00000356150
    RAD51Q066093, ENSP000002678684I2D: score=2 STRING: ENSP00000267868
    RAD9AQ996383, ENSP000003113604I2D: score=2 STRING: ENSP00000311360
    XPAP230253, ENSP000003642704I2D: score=2 STRING: ENSP00000364270
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    BIDP559573, ENSP000003188224I2D: score=1 STRING: ENSP00000318822
    CDC6Q997413, ENSP000002097284I2D: score=1 STRING: ENSP00000209728
    CXXC5Q7LFL83, ENSP000003025434I2D: score=1 STRING: ENSP00000302543
    ESPL1Q146743, ENSP000002579344I2D: score=1 STRING: ENSP00000257934
    FOXO3O435243, ENSP000003395274I2D: score=1 STRING: ENSP00000339527
    IGBP1P783183, ENSP000003487844I2D: score=1 STRING: ENSP00000348784
    MCPH1Q8NEM03, ENSP000003429244I2D: score=1 STRING: ENSP00000342924
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    MED1Q156483, ENSP000003006514I2D: score=1 STRING: ENSP00000300651
    PPP1CCP368733, ENSP000003350844I2D: score=1 STRING: ENSP00000335084
    RFC1P352513, ENSP000002614244I2D: score=1 STRING: ENSP00000261424
    RNF8O760643, ENSP000003625784I2D: score=1 STRING: ENSP00000362578
    RPA2P159273, ENSP000003630214I2D: score=1 STRING: ENSP00000363021
    RRM2BQ7LG563, ENSP000002518104I2D: score=1 STRING: ENSP00000251810
    TAOK3Q9H2K83, ENSP000003763174I2D: score=1 STRING: ENSP00000376317
    XPCQ018313, ENSP000002850214I2D: score=1 STRING: ENSP00000285021
    TP53BP1Q128883, ENSP000003714754I2D: score=3 STRING: ENSP00000371475
    KAT5Q929933, ENSP000003403304I2D: score=2 STRING: ENSP00000340330
    TRIM28Q132632, ENSP000002530244MINT-7945693 STRING: ENSP00000253024
    CREB1P162203, ENSP000003876994I2D: score=2 STRING: ENSP00000387699
    ATF2P153363, ENSP000002641104I2D: score=2 STRING: ENSP00000264110
    BMI1P352263, ENSP000003658514I2D: score=1 STRING: ENSP00000365851
    WRNQ141913, ENSP000002981394I2D: score=3 STRING: ENSP00000298139
    FANCD2Q9BXW93, ENSP000002876474I2D: score=2 STRING: ENSP00000287647
    XRCC6P129562, ENSP000003522574MINT-7945693 STRING: ENSP00000352257
    VHLP403373, ENSP000002564744I2D: score=2 STRING: ENSP00000256474
    AP2B1P630103, ENSP000003144144I2D: score=2 STRING: ENSP00000314414
    BRCA2P515873, ENSP000003694974I2D: score=1 STRING: ENSP00000369497
    DCLRE1AQ6PJP83, ENSP000003551854I2D: score=1 STRING: ENSP00000355185
    EIF3EP602282, ENSP000002208494MINT-7945693 STRING: ENSP00000220849
    EXO1Q9UQ843, ENSP000003118734I2D: score=1 STRING: ENSP00000311873
    KAT8Q9H7Z63, ENSP000004060374I2D: score=1 STRING: ENSP00000406037
    PER3P566452, ENSP000003550314MINT-8052875 STRING: ENSP00000355031
    PEX5P505423, ENSP000004074014I2D: score=2 STRING: ENSP00000407401
    STK11Q158313, ENSP000003248564I2D: score=1 STRING: ENSP00000324856
    TIPARPQ7Z3E13, ENSP000002959244I2D: score=2 STRING: ENSP00000295924
    TOPBP1Q925473, ENSP000002608104I2D: score=2 STRING: ENSP00000260810
    DCLRE1CQ96SD13, ENSP000003675274I2D: score=1 STRING: ENSP00000367527
    HUWE1Q7Z6Z73, ENSP000002628544I2D: score=1 STRING: ENSP00000262854
    MCM2P497363, ENSP000002650564I2D: score=1 STRING: ENSP00000265056
    USP34Q70CQ23, ENSP000003815774I2D: score=1 STRING: ENSP00000381577
    DYRK2Q926303, ENSP000003421054I2D: score=1 STRING: ENSP00000342105
    HNRNPUL1Q9BUJ23, ENSP000003758634I2D: score=1 STRING: ENSP00000375863
    SFNP319473, ENSP000003409894I2D: score=1 STRING: ENSP00000340989
    SREBF1P369563, ENSP000003480694I2D: score=1 STRING: ENSP00000348069
    RUVBL1Q9Y2652, ENSP000003182974MINT-7945693 STRING: ENSP00000318297
    PAXIP1Q6ZW492, ENSP000003840484MINT-7945693 STRING: ENSP00000384048
    AP2A2O949733, ENSP000004132344I2D: score=1 STRING: ENSP00000413234
    PTSQ033933, ENSP000002803624I2D: score=1 STRING: ENSP00000280362
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    RFC3P409382, ENSP000003694114MINT-7945693 STRING: ENSP00000369411
    PPP2R1BP301542, ENSP000003113444MINT-7945693 STRING: ENSP00000311344
    SMARCAD1Q9H4L72, ENSP000003519474MINT-7945693 STRING: ENSP00000351947
    ATRIPQ8WXE13, ENSP000003230994I2D: score=2 STRING: ENSP00000323099
    TAF12Q165142, ENSP000002639744MINT-7945693 STRING: ENSP00000263974
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    TAF9Q165942, ENSP000002178934MINT-7945693 STRING: ENSP00000217893
    CCNB1P146352, ENSP000002564424MINT-7945693 STRING: ENSP00000256442
    BUB1BO605662, ENSP000002875984MINT-7945693 STRING: ENSP00000287598
    CKAP5Q140082, ENSP000003465664MINT-7945693 STRING: ENSP00000346566
    RAD21O602162, ENSP000002973384MINT-7945693 STRING: ENSP00000297338
    BUB1O436832, ENSP000003025304MINT-7945693 STRING: ENSP00000302530
    ELAVL1Q157172, ENSP000003852694MINT-7945693 STRING: ENSP00000385269
    PBRM1Q86U862, ENSP000003492134MINT-7945693 STRING: ENSP00000349213
    PIK3R4Q995702, ENSP000003492054MINT-7945693 STRING: ENSP00000349205
    PPP2R1AP301532, ENSP000003248044MINT-7945693 STRING: ENSP00000324804
    RAD18Q9NS912, ENSP000002649264MINT-7945693 STRING: ENSP00000264926
    SNW1Q135732, ENSP000002615314MINT-7945693 STRING: ENSP00000261531
    TAOK1Q7L7X32, ENSP000002617164MINT-7945693 STRING: ENSP00000261716
    TRIP12Q146692, ENSP000002839434MINT-7945693 STRING: ENSP00000283943
    XRCC5P130103I2D: score=3 
    IKBKBO149203I2D: score=1 
    RASSF1Q9NS233I2D: score=1 
    STAT1P422243I2D: score=1 
    TCL1AP562793I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    TREX1Q9NSU23I2D: score=1 
    ABCF1Q8NE712MINT-7945693
    ABCF3Q9NUQ82MINT-7945693
    ACIN1Q9UKV32MINT-7945693
    ACTBP607092MINT-7945693
    ACTL6AO960192MINT-7945693
    ACTR1AP611632MINT-7945693
    ACTR2P611602MINT-7945693
    ADNPQ9H2P02MINT-7945693
    AHNAKQ096662MINT-7945693
    ANAPC1Q9H1A42MINT-7945693
    ANLNQ9NQW62MINT-7945693
    APBB1IPQ7Z5R62MINT-7945693
    API5Q9BZZ52MINT-7945693
    AQRO603062MINT-7945693
    ARAP1Q96P482MINT-7945693
    ARCN1P484442MINT-7945693
    ARF4P180852MINT-7945693
    ARF5P840852MINT-7945693
    ARFGEF2Q9Y6D52MINT-7945693
    ARHGEF1Q928882MINT-7945693
    ARHGEF2Q929742MINT-7945693
    ARID1AO144972MINT-7945693
    ASUNQ9NVM92MINT-7945693
    ATRXP461002MINT-7945693
    AURKAO149652MINT-7945693
    AURKBQ96GD42MINT-7945693
    BABAM1Q9NWV82MINT-7945693
    BAZ1AQ9NRL22MINT-7945693
    BCAS2O759342MINT-7945693
    BCL7CQ8WUZ02MINT-7945693
    BCLAF1Q9NYF82MINT-7945693
    BRD8Q9H0E92MINT-7945693
    BRIX1Q8TDN62MINT-7945693
    BTAF1O149812MINT-7945693
    BUB3O436842MINT-7945693
    BZW1Q7L1Q62MINT-7945693
    BZW2Q9Y6E22MINT-7945693
    C7orf55-LUC7L2Q9Y3832MINT-7945693
    CAND1Q86VP62MINT-7945693
    CAPGP401212MINT-7945693
    CAPZA1P529072MINT-7945693
    CCNT1O605632MINT-7945693
    CCT2P783712MINT-7945693
    CCT3P493682MINT-7945693
    CCT4P509912MINT-7945693
    CCT5P486432MINT-7945693
    CCT6AP402272MINT-7945693
    CCT7Q998322MINT-7945693
    CCT8P509902MINT-7945693
    CDC16Q130422MINT-7945693
    CDC23Q9UJX22MINT-7945693
    CDC27P302602MINT-7945693
    CDC5LQ994592MINT-7945693
    CDC73Q6P1J92MINT-7945693
    CDK1P064932MINT-7945693
    CDK12Q9NYV42MINT-7945693
    CDK3Q005262MINT-7945693
    CDK9P507502MINT-7945693
    CDKN2AIPQ9NXV62MINT-7945693
    CHD1LQ86WJ12MINT-7945693
    CHD3Q128732MINT-7945693
    CHD7Q9P2D12MINT-7945693
    CHD8Q9HCK82MINT-7945693
    CLP1Q929892MINT-7945693
    COPAP536212MINT-7945693
    COPB1P536182MINT-7945693
    COPB2P356062MINT-7945693
    COPG1Q9Y6782MINT-7945693
    COPG2Q9UBF22MINT-7945693
    COPS3Q9UNS22MINT-7945693
    COPS5Q929052MINT-7945693
    COPS6Q7L5N12MINT-7945693
    CPNE3O751312MINT-7945693
    CPSF1Q105702MINT-7945693
    CPSF2Q9P2I02MINT-7945693
    CPSF3Q9UKF62MINT-7945693
    CPSF4O956392MINT-7945693
    CPSF7Q8N6842MINT-7945693
    CSE1LP550602MINT-7945693
    CSKP412402MINT-7945693
    CSTF3Q129962MINT-7945693
    CTTNQ142472MINT-7945693
    CUL1Q136162MINT-7945693
    DCTN1Q142032MINT-7945693
    DCTN2Q135612MINT-7945693
    DDX17Q928412MINT-7945693
    DDX19AQ9NUU72MINT-7945693
    DDX19BQ9UMR22MINT-7945693
    DDX21Q9NR302MINT-7945693
    DDX23Q9BUQ82MINT-7945693
    DDX39AO001482MINT-7945693
    DDX39BQ138382MINT-7945693
    DDX3XO005712MINT-7945693
    DDX41Q9UJV92MINT-7945693
    DDX42Q86XP32MINT-7945693
    DDX46Q7L0142MINT-7945693
    DDX5P178442MINT-7945693
    DEPDC7Q96QD52MINT-7945693
    DFNA5O604432MINT-7945693
    DHX8Q145622MINT-7945693
    DHX9Q082112MINT-7945693
    DIAPH1O606102MINT-7945693
    DIAPH3Q9NSV42MINT-7945693
    DIDO1Q9BTC02MINT-7945693
    DMAP1Q9NPF52MINT-7945693
    DNAJA1P316892MINT-7945693
    DNAJC13O751652MINT-7945693
    DNM1LO004292MINT-7945693
    DNM2P505702MINT-7945693
    DOCK1Q141852MINT-7945693
    DOCK2Q926082MINT-7945693
    DPF2Q927852MINT-7945693
    DRG1Q9Y2952MINT-7945693
    DSPP159242MINT-7945693
    DYNC1H1Q142042MINT-7945693
    DYNC1LI2O432372MINT-7945693
    EBNA1BP2Q998482MINT-7945693
    EEF1A1P681042MINT-7945693
    EEFSECP577722MINT-7945693
    EFTUD2Q150292MINT-7945693
    EHD1Q9H4M92MINT-7945693
    EHD4Q9H2232MINT-7945693
    EIF2S1P051982MINT-7945693
    EIF2S2P200422MINT-7945693
    EIF2S3P410912MINT-7945693
    EIF3GO758212MINT-7945693
    EIF3HO153722MINT-7945693
    EIF3IQ133472MINT-7945693
    EIF3LQ9Y2622MINT-7945693
    EIF4A1P608422MINT-7945693
    EIF4A3P389192MINT-7945693
    EIF4G2P783442MINT-7945693
    EIF5BO608412MINT-7945693
    ENAHQ8N8S72MINT-7945693
    ENSG00000096150P622692MINT-7945693
    ENSG00000183311P074372MINT-7945693
    ENSG00000206287Q065872MINT-7945693
    ENSG00000206490Q8NE712MINT-7945693
    ENSG00000215425Q138382MINT-7945693
    ENSG00000223367P622692MINT-7945693
    ENSG00000224156P074372MINT-7945693
    ENSG00000225073Q138382MINT-7945693
    ENSG00000225859Q138382MINT-7945693
    ENSG00000225989Q8NE712MINT-7945693
    ENSG00000226225P622692MINT-7945693
    ENSG00000226788Q065872MINT-7945693
    ENSG00000227739P074372MINT-7945693
    ENSG00000228520Q065872MINT-7945693
    ENSG00000229496Q138382MINT-7945693
    ENSG00000229684P074372MINT-7945693
    ENSG00000230624Q138382MINT-7945693
    ENSG00000231115Q065872MINT-7945693
    ENSG00000231129Q8NE712MINT-7945693
    ENSG00000232169Q8NE712MINT-7945693
    ENSG00000232421P074372MINT-7945693
    ENSG00000232575P074372MINT-7945693
    ENSG00000235067P074372MINT-7945693
    ENSG00000235107Q065872MINT-7945693
    ENSG00000235439Q138382MINT-7945693
    ENSG00000235650P622692MINT-7945693
    ENSG00000236149Q8NE712MINT-7945693
    ENSG00000236342Q8NE712MINT-7945693
    ENSG00000258947Q135092MINT-7945693
    EPPK1P581072MINT-7945693
    EPS8L2Q9H6S32MINT-7945693
    ETF1P624952MINT-7945693
    ETV6P412122MINT-7945693
    EXOC1Q9NV702MINT-7945693
    EXOC2Q96KP12MINT-7945693
    EXOC3O606452MINT-7945693
    EXOC4Q96A652MINT-7945693
    EXOC5O004712MINT-7945693
    EXOC7Q9UPT52MINT-7945693
    EXOSC10Q017802MINT-7945693
    EXOSC6Q5RKV62MINT-7945693
    FAM129BQ96TA12MINT-7945693
    FASNP493272MINT-7945693
    FEN1P397482MINT-7945693
    FERMT1Q9BQL62MINT-7945693
    FHOD1Q9Y6132MINT-7945693
    FIP1L1Q6UN152MINT-7945693
    FUBP1Q96AE42MINT-7945693
    FUSP356372MINT-7945693
    FYTTD1Q96QD92MINT-7945693
    G3BP2Q9UN862MINT-7945693
    GATAD2AQ86YP42MINT-7945693
    GATAD2BQ8WXI92MINT-7945693
    GCN1L1Q926162MINT-7945693
    GEMIN4P576782MINT-7945693
    GNA14O958372MINT-7945693
    GSPT1P151702MINT-7945693
    GTF2IP783472MINT-7945693
    GTF3C1Q127892MINT-7945693
    GTF3C2Q8WUA42MINT-7945693
    GTF3C3Q9Y5Q92MINT-7945693
    GTF3C4Q9UKN82MINT-7945693
    GTPBP4Q9BZE42MINT-7945693
    GULP1Q9UBP92MINT-7945693
    HBS1LQ9Y4502MINT-7945693
    HDAC2Q927692MINT-7945693
    HDLBPQ003412MINT-7945693
    HELLSQ9NRZ92MINT-7945693
    HIP1RO751462MINT-7945693
    HIRAP541982MINT-7945693
    HLTFQ145272MINT-7945693
    HNRNPA0Q131512MINT-7945693
    HNRNPA1P096512MINT-7945693
    HNRNPA2B1P226262MINT-7945693
    HNRNPA3P519912MINT-7945693
    HNRNPABQ997292MINT-7945693
    HNRNPCP079102MINT-7945693
    HNRNPDQ141032MINT-7945693
    HNRNPFP525972MINT-7945693
    HNRNPH1P319432MINT-7945693
    HNRNPKP619782MINT-7945693
    HNRNPMP522722MINT-7945693
    HNRNPRO433902MINT-7945693
    HNRNPUQ008392MINT-7945693
    HSP90AA1P079002MINT-7945693
    HSP90AB1P082382MINT-7945693
    HSP90B1P146252MINT-7945693
    HSPA12AO433012MINT-7945693
    HSPA5P110212MINT-7945693
    HSPA8P111422MINT-7945693
    HSPB1P047922MINT-7945693
    HSPD1P108092MINT-7945693
    HTATSF1O437192MINT-7945693
    IKQ131232MINT-7945693
    ILF2Q129052MINT-7945693
    ILF3Q129062MINT-7945693
    ILKQ134182MINT-7945693
    INTS1Q8N2012MINT-7945693
    INTS12Q96CB82MINT-7945693
    INTS3Q68E012MINT-7945693
    IPO5O004102MINT-7945693
    IPO9Q96P702MINT-7945693
    IQGAP1P469402MINT-7945693
    KDM1AO603412MINT-7945693
    KHDRBS1Q076662MINT-7945693
    KIAA1279Q96EK52MINT-7945693
    KIF11P527322MINT-7945693
    KIF21AQ7Z4S62MINT-7945693
    KIF27Q86VH22MINT-7945693
    KIF2CQ996612MINT-7945693
    KIF4AO952392MINT-7945693
    KMT2DO146862MINT-7945693
    KPNA1P522942MINT-7945693
    KPNA2P522922MINT-7945693
    KPNB1Q149742MINT-7945693
    KTI12Q96EK92MINT-7945693
    LDLRAP1Q5SW962MINT-7945693
    LIMS1P480592MINT-7945693
    LMNAP025452MINT-7945693
    LRRC40Q9H9A62MINT-7945693
    LRRC47Q8N1G42MINT-7945693
    LRWD1Q9UFC02MINT-7945693
    LUC7L2Q9Y3832MINT-7945693
    MAD1L1Q9Y6D92MINT-7945693
    MAGED2Q9UNF12MINT-7945693
    MAP2K2P365072MINT-7945693
    MAP2K3P467342MINT-7945693
    MAP2K7O147332MINT-7945693
    MATR3P432432MINT-7945693
    MBD3O959832MINT-7945693
    MDN1Q9NU222MINT-7945693
    MED4Q9NPJ62MINT-7945693
    METTL13Q8N6R02MINT-7945693
    MLKLQ8NB162MINT-7945693
    MORF4L1Q9UBU82MINT-7945693
    MORF4L2Q150142MINT-7945693
    MTA2O947762MINT-7945693
    MVPQ147642MINT-7945693
    MYH9P355792MINT-7945693
    MYO15BQ96JP22MINT-7945693
    NACC1Q96RE72MINT-7945693
    NCAPD2Q150212MINT-7945693
    NCAPGQ9BPX32MINT-7945693
    NCAPHQ150032MINT-7945693
    NCLP193382MINT-7945693
    NCOR1O753762MINT-7945693
    NCOR2Q9Y6182MINT-7945693
    NDC80O147772MINT-7945693
    NELFBQ8WX922MINT-7945693
    NELFCDQ8IXH72MINT-7945693
    NFICP086512MINT-7945693
    NIPBLQ6KC792MINT-7945693
    NOLC1Q149782MINT-7945693
    NONOQ152332MINT-7945693
    NR2C2P491162MINT-7945693
    NR2F2P244682MINT-7945693
    NR2F6P105882MINT-7945693
    NSFP464592MINT-7945693
    NSUN5Q96P112MINT-7945693
    NUDCQ9Y2662MINT-7945693
    NUF2Q9BZD42MINT-7945693
    NUP153P497902MINT-7945693
    NUP155O756942MINT-7945693
    NUP37Q8NFH42MINT-7945693
    OLA1Q9NTK52MINT-7945693
    ORC2Q134162MINT-7945693
    ORC3Q9UBD52MINT-7945693
    OTULINQ96BN82MINT-7945693
    OXSR1O957472MINT-7945693
    PABPC1P119402MINT-7945693
    PABPN1Q86U422MINT-7945693
    PAK1Q131532MINT-7945693
    PAK4O960132MINT-7945693
    PARP4Q9UKK32MINT-7945693
    PARVAQ9NVD72MINT-7945693
    PARVBQ9HBI12MINT-7945693
    PCBP2Q153662MINT-7945693
    PCF11O949132MINT-7945693
    PDCD6IPQ8WUM42MINT-7945693
    PDLIM7Q9NR122MINT-7945693
    PELP1Q8IZL82MINT-7945693
    PFKMP082372MINT-7945693
    PFKPQ018132MINT-7945693
    PHGDHO431752MINT-7945693
    PICALMQ134922MINT-7945693
    PKN2Q165132MINT-7945693
    PKP3Q9Y4462MINT-7945693
    PLECQ151492MINT-7945693
    PLK1P533502MINT-7945693
    PLRG1O436602MINT-7945693
    PNNQ9H3072MINT-7945693
    POGZQ7Z3K32MINT-7945693
    POLD1P283402MINT-7945693
    POLEQ078642MINT-7945693
    POLR1CO151602MINT-7945693
    POLR2AP249282MINT-7945693
    POLR2EP193882MINT-7945693
    PRKAG1P546192MINT-7945693
    PRPF19Q9UMS42MINT-7945693
    PRPF40AO754002MINT-7945693
    PRPF6O949062MINT-7945693
    PRPF8Q6P2Q92MINT-7945693
    PSMC1P621912MINT-7945693
    PSMC2P359982MINT-7945693
    PSMC3P179802MINT-7945693
    PSMC4P436862MINT-7945693
    PSMC5P621952MINT-7945693
    PSMC6P623332MINT-7945693
    PSMD1Q994602MINT-7945693
    PSMD11O002312MINT-7945693
    PSMD12O002322MINT-7945693
    PSMD13Q9UNM62MINT-7945693
    PSMD2Q132002MINT-7945693
    PSMD3O432422MINT-7945693
    PTBP1P265992MINT-7945693
    PUF60Q9UHX12MINT-7945693
    PUM2Q8TB722MINT-7945693
    PURAQ005772MINT-7945693
    PWP1Q136102MINT-7945693
    RACGAP1Q9H0H52MINT-7945693
    RAE1P784062MINT-7945693
    RALYQ9UKM92MINT-7945693
    RANBP2P497922MINT-7945693
    RANGAP1P460602MINT-7945693
    RBBP5Q152912MINT-7945693
    RBBP7Q165762MINT-7945693
    RBM10P981752MINT-7945693
    RBM14Q96PK62MINT-7945693
    RBM15Q96T372MINT-7945693
    RBM17Q96I252MINT-7945693
    RBM39Q144982MINT-7945693
    RBM4Q9BWF32MINT-7945693
    RBM45Q8IUH32MINT-7945693
    RBMXP381592MINT-7945693
    RCOR1Q9UKL02MINT-7945693
    RFC2P352502MINT-7945693
    RFC4P352492MINT-7945693
    RFC5P409372MINT-7945693
    RIF1Q5UIP02MINT-7945693
    RING1Q065872MINT-7945693
    RIOK1Q9BRS22MINT-7945693
    RNF2Q994962MINT-7945693
    ROCK2O751162MINT-7945693
    RPL12P300502MINT-7945693
    RPL13P263732MINT-7945693
    RPL19P840982MINT-7945693
    RPL22P352682MINT-7945693
    RPL23AP627502MINT-7945693
    RPL3P390232MINT-7945693
    RPL31P628992MINT-7945693
    RPL36Q9Y3U82MINT-7945693
    RPL4P365782MINT-7945693
    RPL7AP624242MINT-7945693
    RPL8P629172MINT-7945693
    RPLP0P053882MINT-7945693
    RPS14P622632MINT-7945693
    RPS18P622692MINT-7945693
    RPS19P390192MINT-7945693
    RPS25P628512MINT-7945693
    RPS3P233962MINT-7945693
    RPS6KA4O756762MINT-7945693
    RPS6KB2Q9UBS02MINT-7945693
    RTCBQ9Y3I02MINT-7945693
    RUVBL2Q9Y2302MINT-7945693
    SART1O432902MINT-7945693
    SCYL2Q6P3W72MINT-7945693
    SEC23BQ154372MINT-7945693
    SEC31BQ9NQW12MINT-7945693
    SEH1LQ96EE32MINT-7945693
    SEPT7Q161812MINT-7945693
    SEPT9Q9UHD82MINT-7945693
    SETXQ7Z3332MINT-7945693
    SF3A1Q154592MINT-7945693
    SF3A3Q128742MINT-7945693
    SF3B1O755332MINT-7945693
    SF3B2Q134352MINT-7945693
    SF3B3Q153932MINT-7945693
    SF3B4Q154272MINT-7945693
    SF3B6Q9Y3B42MINT-7945693
    SFPQP232462MINT-7945693
    SHOC2Q9UQ132MINT-7945693
    SHROOM3Q8TF722MINT-7945693
    SMARCA2P515312MINT-7945693
    SMARCA5O602642MINT-7945693
    SMARCC1Q929222MINT-7945693
    SMARCC2Q8TAQ22MINT-7945693
    SMARCD1Q96GM52MINT-7945693
    SMARCE1Q969G32MINT-7945693
    SMC2O953472MINT-7945693
    SMC4Q9NTJ32MINT-7945693
    SMCHD1A6NHR92MINT-7945693
    SMN1Q166372MINT-7945693
    SMN2Q166372MINT-7945693
    SND1Q7KZF42MINT-7945693
    SNRNP200O756432MINT-7945693
    SNRNP40Q96DI72MINT-7945693
    SNRNP70P086212MINT-7945693
    SNRPB2P085792MINT-7945693
    SNRPD3P623182MINT-7945693
    SNUPNO951492MINT-7945693
    SPATA5Q8NB902MINT-7945693
    SPATA5L1Q9BVQ72MINT-7945693
    SPTAN1Q138132MINT-7945693
    SPTBN1Q010822MINT-7945693
    SQSTM1Q135012MINT-7945693
    SRP19P091322MINT-7945693
    SRP54P610112MINT-7945693
    SRP68Q9UHB92MINT-7945693
    SRP72O760942MINT-7945693
    SRRM1Q8IYB32MINT-7945693
    SRRM2Q9UQ352MINT-7945693
    SRSF1Q079552MINT-7945693
    SRSF11Q055192MINT-7945693
    SRSF2Q011302MINT-7945693
    SRSF3P841032MINT-7945693
    SRSF5Q132432MINT-7945693
    SRSF6Q132472MINT-7945693
    SRSF7Q166292MINT-7945693
    STAG1Q8WVM72MINT-7945693
    SUGT1Q9Y2Z02MINT-7945693
    SUPV3L1Q8IYB82MINT-7945693
    SYMPKQ927972MINT-7945693
    SYNCRIPO605062MINT-7945693
    TARDBPQ131482MINT-7945693
    TBL1XR1Q9BZK72MINT-7945693
    TCP1P179872MINT-7945693
    THOC1Q96FV92MINT-7945693
    THOC2Q8NI272MINT-7945693
    THRAP3Q9Y2W12MINT-7945693
    TIAL1Q010852MINT-7945693
    TLN1Q9Y4902MINT-7945693
    TMPOP421662MINT-7945693
    TOX4O948422MINT-7945693
    TRAP1Q129312MINT-7945693
    TRIP13Q156452MINT-7945693
    TRUB1Q8WWH52MINT-7945693
    TSG101Q998162MINT-7945693
    TTKP339812MINT-7945693
    TUBA3EQ6PEY22MINT-7945693
    TUBA4AP683662MINT-7945693
    TUBBP074372MINT-7945693
    TUBB1Q9H4B72MINT-7945693
    TUBB3Q135092MINT-7945693
    TUBB4BP683712MINT-7945693
    TUBG1P232582MINT-7945693
    TUBGCP2Q9BSJ22MINT-7945693
    TUBGCP3Q96CW52MINT-7945693
    TUFMP494112MINT-7945693
    TWF1Q127922MINT-7945693
    U2AF1Q010812MINT-7945693
    U2AF2P263682MINT-7945693
    U2SURPO150422MINT-7945693
    UBA5Q9GZZ92MINT-7945693
    UBE2MP610812MINT-7945693
    UBE2NP610882MINT-7945693
    UBE2Q1Q7Z7E82MINT-7945693
    UBL4AP114412MINT-7945693
    UCHL5Q9Y5K52MINT-7945693
    UNC45AQ9H3U12MINT-7945693
    UPF2Q9HAU52MINT-7945693
    USP39Q53GS92MINT-7945693
    USP48Q86UV52MINT-7945693
    VASPP505522MINT-7945693
    VIMP086702MINT-7945693
    VPS33BQ9H2672MINT-7945693
    VRK1Q999862MINT-7945693
    WAPALQ7Z5K22MINT-7945693
    WDR18Q9BV382MINT-7945693
    WDR33Q9C0J82MINT-7945693
    WDR5P619642MINT-7945693
    WIZO957852MINT-7945693
    XPO6Q96QU82MINT-7945693
    XRN2Q9H0D62MINT-7945693
    YBX3P169892MINT-7945693
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint ----
    GO:0000723telomere maintenance ----
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0001666response to hypoxia IEA--
    GO:0001756somitogenesis IEA--

    Find genes that share ontologies with ATM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    4 ApexBio Compounds for ATM     About this table
    CompoundAction CAS #
    AZ20potent and selective inhibitor of ATR[1233339-22-4]
    KU 55933Potent and selective ATM inhibitor[587871-26-9]
    KU-60019Potent and selective ATM kinase inhibitor[925701-49-1]
    VE-821Cell-permeable and ATP-competitive ATM kinase inhibitor[1232410-49-9]

    Compounds for ATM available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KU 55933Potent and selective ATM kinase inhibitor[587871-26-9]
    KU 60019Potent ATM kinase inhibitor[925701-46-8]

    2 HMDB Compounds for ATM    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for ATM gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 58.6 27 11114307 (1), 17507690 (1), 9442910 (1), 12513844 (1) (see all 24)
    wortmannin 56.5 24 10771089 (3), 15173573 (2), 9808536 (2), 15709017 (1) (see all 14)
    neocarzinostatin 50.7 3 15345673 (1), 9244351 (1), 9050866 (1)
    caffeine 50.2 33 10485486 (4), 16479016 (2), 11864911 (2), 10744722 (2) (see all 19)
    aphidicolin 46.5 5 11279043 (1), 11114888 (1)
    hydroxyurea 43.4 6 11689451 (1), 16293623 (1), 11114888 (1)
    topotecan 35.2 11 18802408 (3), 16426422 (3), 16760673 (2), 16184611 (1)
    camptothecin 32.1 15 20304914 (5), 15699047 (2), 16158199 (1), 10327072 (1)
    mitoxantrone 30.9 10 16760673 (4), 18802408 (3), 16184611 (1), 19411853 (1)
    ly294002 30.4 8 10771089 (3), 18589211 (1), 19038232 (1)



    Find genes that share compounds with ATM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for ATM gene (3 alternative transcripts): 
    NM_000051.3  NM_138292.3  NM_138293.1  

    Unigene Cluster for ATM:

    Ataxia telangiectasia mutated
    Hs.367437  [show with all ESTs]
    Unigene Representative Sequence: NM_000051
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000527805(uc009yxs.1) ENST00000527891 ENST00000532931 ENST00000530958
    ENST00000452508(uc001pke.2) ENST00000526567(uc001pkc.1) ENST00000601453
    ENST00000525012 ENST00000533526 ENST00000419286 ENST00000533733(uc001pkd.4)
    ENST00000524792 ENST00000531525(uc001pkf.3) ENST00000531957 ENST00000533690(uc009yxt.1 uc001pkg.1)
    ENST00000534625 ENST00000529588 ENST00000532765
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATM (see all 15):
    hsa-miR-34c-3p hsa-miR-203 hsa-miR-18a hsa-miR-181c hsa-miR-516b hsa-miR-181a hsa-miR-519c-3p hsa-miR-181d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ATM
    Predesigned siRNA for gene silencing in human, mouse, rat ATM
    Clone
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    OriGene clones in human, mouse for ATM (see all 9)
    OriGene ORF clones in mouse, rat for ATM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATM (NM_000051)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATM
    Addgene plasmids for ATM 
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    OriGene qSTAR qPCR primer pairs in human, mouse for ATM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATM
      QuantiTect SYBR Green Assays in human, mouse, rat ATM
      QuantiFast Probe-based Assays in human, mouse, rat ATM
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12375) for ATM 

    Additional mRNA sequence: 

    AF035326.1 AF035327.1 AF035328.1 AK093586.1 AK299843.1 BC007023.2 BC022306.1 BC061584.1 
    BC152385.1 BC152389.1 BT006764.1 BX640631.1 CR749436.1 HM437232.1 U33841.1 U67093.1 
    X91196.1 Y08455.1 

    21 DOTS entries:

    DT.102832095  DT.100750015  DT.91916232  DT.91717023  DT.101977439  DT.99971554  DT.121643246  DT.451837 
    DT.100750014  DT.99928041  DT.120760397  DT.65284599  DT.97778369  DT.120760409  DT.120760428  DT.40122485 
    DT.75194025  DT.91664691  DT.97825561  DT.120760412  DT.99957611 

    Selected AceView cDNA sequences (see all 200):

    AI523344 NM_000051 BX096702 AA962359 AI559463 AA890626 BM671057 BC007023 
    AA236739 AA149636 U26455 BM697241 BG942504 BM800438 AA814352 NM_138292 
    BX642224 BX504088 BX644571 R26821 BQ005085 AI479273 CA392919 AV705298 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ATM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ATM Expression
    About this image


    ATM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Gonad
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primordial Follicle
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    ATM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367437

    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
    Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen,
    thymus, testis, ovary, small intestine, colon and leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATM (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ATM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATM
    QuantiTect SYBR Green Assays in human, mouse, rat ATM
    QuantiFast Probe-based Assays in human, mouse, rat ATM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATM gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atm1 , 5 ataxia telangiectasia mutated homolog (human)1, 5 84.99(n)1
    84.34(a)1
      9 (29.12 cM)5
    119201  NM_007499.21  NP_031525.21 
     534391495 
    chicken
    (Gallus gallus)
    Aves ATM1 ataxia telangiectasia mutated 72.23(n)
    69.69(a)
      395401  NM_001162400.1  NP_001155872.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATM6
    ataxia telangiectasia mutated
    60(a)
    1 ↔ 1
    GL343319.1(1173-53757)
    African clawed frog
    (Xenopus laevis)
    Amphibia ATM2 ataxia telangiectasia mutated 75.21(n)    AF174488.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.286552 Danio rerio partial mRNA for ataxia telangiectasia more 73.34(n)    AJ605775.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65353 cell cycle checkpoint protein kinase 27(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea atm-16
    Protein ATM-1 (atm-1) mRNA, complete cds
    18(a)
    1 ↔ 1
    I(183364-208467) WBGene00000227
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TEL1(YBL088C)4 Protein kinase primarily involved in telomere length more   --   2(59382-51019) 852190  NP_009465.1 
    rice
    (Oryza sativa)
    Liliopsida Os.170832 Oryza sativa (japonica cultivar-group) AtATM like protein more 75(n)    NM_183488.1 


    ENSEMBL Gene Tree for ATM (if available)
    TreeFam Gene Tree for ATM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for ATM gene
    1 SIMAP similar gene for ATM using alignment to 14 protein entries:     ATM_HUMAN (see all proteins):
    DKFZp781A0353

    Find genes that share paralogs with ATM           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ATM
    PGOHUM00000233233


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATM (see all 3368)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30928571,2,,4
    C,F,HB-cell non-Hodgkin lymphoma4 other1108007477(+) TAAGAA/GTGGCC 2 M V mis126Minor allele frequency- G:0.01NA MN NS EA 7154
    VAR_0108014
    Ataxia telangiectasia (AT)4--see VAR_0108012 K E mis40--------
    VAR_0108464
    Ataxia telangiectasia (AT)4--see VAR_0108462 R C mis40--------
    VAR_0108794
    Ataxia telangiectasia (AT)4--see VAR_0108792 F C mis40--------
    VAR_0108164
    Ataxia telangiectasia (AT)4--see VAR_0108162 L Q mis40--------
    VAR_0108634
    Ataxia telangiectasia (AT)4--see VAR_0108632 D Q mis40--------
    VAR_0415804
    A lung adenocarcinoma sample4--see VAR_0415802 T A mis40--------
    VAR_0108804
    Ataxia telangiectasia (AT)4--see VAR_0108802 P L mis40--------
    VAR_0108264
    Ataxia telangiectasia (AT)4--see VAR_0108262 L P mis40--------
    VAR_0108904
    Ataxia telangiectasia (AT)4--see VAR_0108902 R G mis40--------

    HapMap Linkage Disequilibrium report for ATM (108093211 - 108239829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ATM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832262CNV Loss17160897
    dgv1315n71CNV Loss21882294
    nsv898385CNV Loss21882294
    nsv832263CNV Gain17160897

    Human Gene Mutation Database (HGMD): ATM
    Locus Specific Mutation Databases (LSDB): ATM

    Selected Site Specific Mutation Identification with PCR Assays for ATM (see all 6):
    Cosmic IdAA Change
    20404p.R2443Q
    21826p.F858L
    21624p.R3047*
    12951p.Q2442P
    21642p.R3008C
    5 Site Specific Cancer Mutation PCR Panels containing ATM:
    Lymphoid Neoplasms
    Lung and Colon Cancers (Expanded Panel) 384HT
    Pathway
    Cancer Comprehensive Panel 384HT
    Tumor Suppressor Panel 384HT
    SeqTarget long-range PCR primers for resequencing ATM
    DNA2.0 Custom Variant and Variant Library Synthesis for ATM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607585   
    OMIM disorders: 208900  114480  
    UniProtKB/Swiss-Prot: ATM_HUMAN, Q13315
  • Ataxia telangiectasia (AT) [MIM:208900]: A rare recessive disorder characterized by progressive
    cerebellar ataxia, dilation of the blood vessels in the conjunctiva and eyeballs, immunodeficiency, growth
    retardation and sexual immaturity. Patients have a strong predisposition to cancer; about 30% of patients develop
    tumors, particularly lymphomas and leukemias. Cells from affected individuals are highly sensitive to damage by
    ionizing radiation and resistant to inhibition of DNA synthesis following irradiation. Note=The disease is caused
    by mutations affecting the gene represented in this entry
  • Note=Defects in ATM contribute to T-cell acute lymphoblastic leukemia (TALL) and T-prolymphocytic
    leukemia (TPLL). TPLL is characterized by a high white blood cell count, with a predominance of prolymphocytes,
    marked splenomegaly, lymphadenopathy, skin lesions and serous effusion. The clinical course is highly aggressive,
    with poor response to chemotherapy and short survival time. TPLL occurs both in adults as a sporadic disease and
    in younger AT patients
  • Note=Defects in ATM contribute to B-cell non-Hodgkin lymphomas (BNHL), including mantle cell lymphoma
    (MCL)
  • Note=Defects in ATM contribute to B-cell chronic lymphocytic leukemia (BCLL). BCLL is the commonest form
    of leukemia in the elderly. It is characterized by the accumulation of mature CD5+ B-lymphocytes,
    lymphadenopathy, immunodeficiency and bone marrow failure

  • Selected diseases for ATM (see all 26):    
    About MalaCards
    b-cell chronic lymphocytic leukemia    chromosome 11q deletion    mantle cell lymphoma    ataxia-telangiectasia variant
    t-cell prolymphocytic leukemia, somatic    lymphoma, b-cell non-hodgkin, somatic    combined cervical dystonia    ataxia telangiectasia
    nijmegen breakage syndrome-like disorder    cll/sll    t-cell prolymphocytic leukemia    ataxia
    campomelic dysplasia with autosomal sex reversal    campomelic dysplasia    nijmegen breakage syndrome    breast cancer
    bilateral breast cancer    chronic lymphocytic leukemia    telangiectasis    prolymphocytic leukemia

    10 diseases from the University of Copenhagen DISEASES database for ATM:
    Ataxia telangiectasia     Nijmegen breakage syndrome     Breast cancer     Genetic disorder
    Telangiectasis     Cerebellar ataxia     Leukemia     Lymphoma
    Fanconi's anemia     Seckel syndrome

    Find genes that share disorders with ATM           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ATM gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 98.2 473 9622061 (3), 16799570 (3), 7545545 (2), 8843194 (2) (see all 99)
    nijmegen breakage syndrome 87.5 20 15024084 (1), 17507690 (1), 18215521 (1), 18723444 (1) (see all 17)
    cerebellar degeneration 77.4 4 9054948 (1), 9770541 (1), 8968760 (1), 11443540 (1)
    telangiectasia 70.7 13 12882767 (4), 18502988 (2), 19799357 (1), 12513844 (1) (see all 8)
    genetic disorder 69.8 40 10549596 (2), 7545545 (1), 9535798 (1), 10567403 (1) (see all 39)
    lymphocytic leukemia chronic b-cell 65.4 16 11468183 (2), 9892178 (1), 9788599 (1), 10738255 (1) (see all 14)
    cancer 63.5 122 12513844 (4), 18565893 (4), 12195425 (3), 15390180 (3) (see all 83)
    leukemia prolymphocytic 62.7 8 9573030 (2), 10738255 (1), 12149228 (1), 18073348 (1) (see all 7)
    bilateral breast cancer 60.9 10 19153073 (3), 12673797 (1), 14562025 (1), 15756685 (1) (see all 5)
    fanconis anemia 59.3 1 11733219 (1)

    GeneTests: ATM
    GeneReviews: ATM
    Genetic Association Database (GAD): ATM
    Human Genome Epidemiology (HuGE) Navigator: ATM (170 documents)
    Tumor Gene Database (TGDB): ATM

    Export disorders for ATM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATM gene, integrated from 10 sources (see all 1426):
    (articles sorted by number of sources associating them with ATM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations associated with variant phenotypes in ataxia- telangiectasia. (PubMed id 8755918)1, 2, 4 McConville C.M.... Taylor A.M.R. (Am. J. Hum. Genet. 1996)
    2. ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects. (PubMed id 11849780)1, 4, 9 Iannuzzi C.M....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2002)
    3. Inactivation of the ATM gene in T-cell prolymphocytic leukemias. (PubMed id 9573030)1, 2, 9 Stoppa-Lyonnet D.... Stern M.-H. (Blood 1998)
    4. Ataxia-telangiectasia locus: sequence analysis of 184 kb of human genomic DNA containing the entire ATM gene. (PubMed id 9199932)1, 2, 9 Platzer M.... Rosenthal A. (Genome Res. 1997)
    5. Contribution of mutations in ATM to breast cancer development in the Czech population. (PubMed id 18497957)1, 4, 9 Soukupova J....Pohlreich P. (Oncol. Rep. 2008)
    6. Detection of ATM gene mutations in young lung cancer patients: a population-based control study. (PubMed id 18164969)1, 4, 9 Schneider J....Wichmann H.E. (Arch. Med. Res. 2008)
    7. The product of the ATM gene is a 370-kDa nuclear phosphoprotein. (PubMed id 8969240)1, 2, 9 Chen G. and Lee E.Y.-H.P. (J. Biol. Chem. 1996)
    8. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. (PubMed id 17923702)1, 2, 9 Sun Y.... Price B.D. (Mol. Cell. Biol. 2007)
    9. Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity. (PubMed id 10873394)1, 2, 9 Becker-Catania S.G.... Gatti R.A. (Mol. Genet. Metab. 2000)
    10. Mantle cell lymphoma is characterized by inactivation of the ATM gene. (PubMed id 10706620)1, 2, 9 Schaffner C.... Lichter P. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 472 HGNC: 795 AceView: ATM Ensembl:ENSG00000149311 euGenes: HUgn472
    ECgene: ATM Kegg: 472 H-InvDB: ATM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATM Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ATM[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/atm/
    Wikipedia http://en.wikipedia.org/wiki/Ataxia_telangiectasia_mutated

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATM gene:
    Search GeneIP for patents involving ATM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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