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ATL3 Gene

protein-coding   GIFtS: 50
GCID: GC11M063391

Atlastin GTPase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Atlastin GTPase 31 2
HSN1F2 5
atlastin-32
EC 3.6.5.-3

External Ids:    HGNC: 245261   Entrez Gene: 259232   Ensembl: ENSG000001847437   OMIM: 6093695   UniProtKB: Q6DD883   

Export aliases for ATL3 gene to outside databases

Previous GC identifers: GC11M063154 GC11M059725


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATL3 Gene:
This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required
for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this
gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that
encode distinct isoforms have been described. (provided by RefSeq, Feb 2014)

GeneCards Summary for ATL3 Gene:
ATL3 (atlastin GTPase 3) is a protein-coding gene. Diseases associated with ATL3 include spastic paraplegia 3, and spastic paraplegia 3a. GO annotations related to this gene include GTPase activity and identical protein binding. An important paralog of this gene is RNF112.

UniProtKB/Swiss-Prot: ATLA3_HUMAN, Q6DD88
Function: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of
endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATL3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATL3 promoter sequence
   Search Chromatin IP Primers for ATL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

ATL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATL3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M063391:  view genomic region     (about GC identifiers)

Start:
63,391,559 bp from pter      End:
63,439,393 bp from pter
Size:
47,835 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATLA3_HUMAN, Q6DD88 (See protein sequence)
Recommended Name: Atlastin-3  
Size: 541 amino acids; 60542 Da
Sequence caution: Sequence=BAC05111.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q8N7W5 Q9H8Q5 Q9UFL1

Explore the universe of human proteins at neXtProt for ATL3: NX_Q6DD88

Explore proteomics data for ATL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys239, Lys391
  • Modification sites at PhosphoSitePlus

  • See ATL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001276977.1  NP_056274.3  

    ENSEMBL proteins: 
     ENSP00000381844   ENSP00000437593   ENSP00000441842   ENSP00000329034  

    ATL3 Human Recombinant Protein Products:

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    Novus Biologicals ATL3 Protein
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015894 Guanylate-bd_N
     IPR027417 P-loop_NTPase
     IPR003191 Guanylate-bd_C

    Graphical View of Domain Structure for InterPro Entry Q6DD88

    ProtoNet protein and cluster: Q6DD88

    UniProtKB/Swiss-Prot: ATLA3_HUMAN, Q6DD88
    Similarity: Belongs to the GBP family. Atlastin subfamily


    ATL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATLA3_HUMAN, Q6DD88
    Function: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of
    endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis

         Enzyme Number (IUBMB): EC 3.6.5.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS18270207
    GO:0005525GTP binding IEA--
    GO:0042802identical protein binding IDA18270207
         
    ATL3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATL3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATL3

    miRNA
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    miRTarBase miRNAs that target ATL3:
    hsa-mir-1 (MIRT023532), hsa-mir-186-5p (MIRT044964), hsa-mir-20a-5p (MIRT050590)

    Block miRNA regulation of human, mouse, rat ATL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATL3 (see all 18):
    hsa-miR-320a hsa-miR-142-5p hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-2115 hsa-miR-93 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidATL3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATLA3_HUMAN, Q6DD88: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    golgi apparatus2
    peroxisome2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18270207
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IDA18270207

    ATL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATL3
    Interactions:

        Search GeneGlobe Interaction Network for ATL3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ATL3 (Q6DD882, 3 ENSP000003818444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3308328 I2D: score=1 STRING: ENSP00000309503
    UBCENSP000003448184STRING: ENSP00000344818
    ARRDC3ENSP000002651384STRING: ENSP00000265138
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS18270207
    GO:0006888NOT ER to Golgi vesicle-mediated transport IMP18270207
    GO:0007029endoplasmic reticulum organization IMP18270207
    GO:0007030Golgi organization IMP18270207
    GO:0051260protein homooligomerization IDA18270207

    ATL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATL3 (ATLA3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATL3 gene (2 alternative transcripts): 
    NM_001290048.1  NM_015459.4  

    Unigene Cluster for ATL3:

    Atlastin GTPase 3
    Hs.356719  [show with all ESTs]
    Unigene Representative Sequence: CR936784
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398868(uc001nxk.1) ENST00000538786 ENST00000540699(uc001nxl.1)
    ENST00000535789 ENST00000332645(uc010rmr.1 uc010rms.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat ATL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATL3 (see all 18):
    hsa-miR-320a hsa-miR-142-5p hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-2115 hsa-miR-93 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidATL3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ATL3 (NM_015459)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATL3
    Primer
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    OriGene qPCR primer pairs and template standards for ATL3
    OriGene qSTAR qPCR primer pairs in human, mouse for ATL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATL3
      QuantiTect SYBR Green Assays in human, mouse, rat ATL3
      QuantiFast Probe-based Assays in human, mouse, rat ATL3

    Additional mRNA sequence: 

    AK023383.1 AK090822.1 AK094227.1 AK097588.1 AK301910.1 AL117600.1 BC077727.1 BX648468.1 
    CR936784.1 

    16 DOTS entries:

    DT.100813927  DT.100035958  DT.95373254  DT.75146147  DT.100813925  DT.91744011  DT.91763671  DT.95309161 
    DT.100660679  DT.100669886  DT.211228  DT.92025976  DT.100785791  DT.121044751  DT.92071310  DT.95377774 

    Selected AceView cDNA sequences (see all 341):

    BG943904 CB127749 AI246891 AA987508 CB107188 BX484988 N58968 BX279978 
    CF272483 H88918 AI829194 BX505706 AI695327 AW072940 AK023383 AA600902 
    CK906206 CA415235 NM_015459 AW243781 AA584254 AI189301 AW136278 BQ084026 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ATL3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                -                                                   
    SP2:              -                 -                                                   
    SP3:              -     -     -     -                                                   
    SP4:                                                                                    


    ECgene alternative splicing isoforms for ATL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ATL3 Expression
    About this image

    ATL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356719

    UniProtKB/Swiss-Prot: ATLA3_HUMAN, Q6DD88
    Tissue specificity: Expressed in peripheral tissues (at protein level)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATL3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atl31 , 5 atlastin GTPase 31, 5 90.02(n)1
    94.64(a)1
      19 (5.32 cM)5
    1091681  NM_146091.41  NP_666203.31 
     74940405 
    lizard
    (Anolis carolinensis)
    Reptilia ATL36
    atlastin GTPase 3
    73(a)
    1 ↔ 1
    GL343890.1(68886-89317)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atl31 atlastin GTPase 3 70.57(n)
    77.74(a)
      549349  NM_001016595.2  NP_001016595.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atl31 atlastin 3 67.14(n)
    71.28(a)
      449995  NM_001006016.1  NP_001006016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta atl6
    atlastin
    50(a)
    1 → many
    3R(20451397-20460436)
    worm
    (Caenorhabditis elegans)
    Secernentea atln-16
    Protein Y54G2A.2, isoform a
    50(a)
    1 → many
    IV(2788692-2796813) WBGene00021868


    ENSEMBL Gene Tree for ATL3 (if available)
    TreeFam Gene Tree for ATL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATL3 gene
    RNF1122  ATL22  ATL12  
    3 SIMAP similar genes for ATL3 using alignment to 4 protein entries:     ATLA3_HUMAN (see all proteins):
    ATL1    SPG3A    ATL2

    ATL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATL3 (see all 904)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495623971,2
    --63396041(+) GCTCAC/GGCCTG 1 -- ds50010--------
    rs1444137811,2
    C--63396042(+) CTCACA/GCCTGT 1 -- ds50010--------
    rs1410345821,2
    C--63396177(+) GTGGCA/GTACAC 1 -- ds50010--------
    rs1448796501,2
    --63396231(+) TGAACC/TCGGCA 1 -- ds50010--------
    rs1475161611,2
    C--63396250(+) TTGCAC/GTGAGC 1 -- ds50010--------
    rs1912761311,2
    --63396352(+) GTAAAA/GTATAA 1 -- ds50010--------
    rs171584531,2
    C,F,H--63396384(+) GAAAAC/TGGCAC 1 -- ds500124Minor allele frequency- T:0.12NA NS EA CSA WA 2462
    rs1831890231,2
    --63396447(+) AATCAA/TTCTTA 1 -- ut310--------
    rs1876405211,2
    --63396553(+) AAAATA/TGACAC 1 -- ut310--------
    rs1128173391,2
    C,F--63396665(+) GGGCCG/ATGTTT 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ATL3 (63391559 - 63439393 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ATL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv353CNV Loss18451855
    nsv832183CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATL3
    DNA2.0 Custom Variant and Variant Library Synthesis for ATL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609369   
    OMIM disorders: 615632  
    8 diseases for ATL3:    
    About MalaCards
    spastic paraplegia 3    spastic paraplegia 3a    neuropathy, hereditary sensory and autonomic, type ia    primary pulmonary hypertension
    hereditary spastic paraplegia    paraplegia    spasticity    hypertension

    1 disease from the University of Copenhagen DISEASES database for ATL3:
    Primary pulmonary hypertension

    ATL3 for disorders           About GeneDecksing


    Export disorders for ATL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATL3 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ATL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. (PubMed id 18270207)1, 2, 3 Rismanchi N.... Blackstone C. (Hum. Mol. Genet. 2008)
    2. A class of dynamin-like GTPases involved in the generation of the tubular ER network. (PubMed id 19665976)1, 2 Hu J.... Blackstone C. (Cell 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3. (PubMed id 24459106)1 Kornak U....Kurth I. (Brain 2014)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25923 HGNC: 24526 AceView: DKFZP564J0863 Ensembl:ENSG00000184743 euGenes: HUgn25923
    ECgene: ATL3 H-InvDB: ATL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATL3 gene:
    Search GeneIP for patents involving ATL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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