ATL3 Gene
protein-coding GIFtS: 46
GCID: GC11M063391
|
|
atlastin GTPase 3
| |
Aliases
for ATL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Atlastin GTPase 31 2 | | DKFZP564J08631 | | Atlastin 32 | | Atlastin-31 | | EC 3.6.5.-3 |
Export aliases for ATL3 gene to outside databasesPrevious GC identifers: GC11M063154 GC11M059725 |
Summaries
for ATL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ATLA3_HUMAN, Q6DD88Function: GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion ofendoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis
|
Genomic Views
for ATL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATL3 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F E2F-2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1ATL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M063391: view genomic region
(about GC identifiers)
Start:
|
63,391,559 bp from pter |
End:
|
63,439,393 bp from pter |
Size:
|
47,835 bases |
Orientation:
|
minus strand |
|
Proteins
for ATL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATLA3_HUMAN, Q6DD88 (See
protein sequence)Recommended Name: Atlastin-3 Size: 541 amino acids; 60542 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC05111.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q8N7W5 Q9H8Q5 Q9UFL1Explore the universe of human proteins at neXtProt for ATL3: NX_Q6DD88
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6DD88
ATL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056274.3
ENSEMBL proteins: ENSP00000381844 ENSP00000437593 ENSP00000441842 ENSP00000329034
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ATL3 for ontologies About GeneDecksing
ATL3 Antibody Products:
Assay Products for ATL3: |
Protein
Domains /
Families
for ATL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATL3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6DD88ProtoNet protein and cluster: Q6DD88 UniProtKB/Swiss-Prot: ATLA3_HUMAN, Q6DD88Similarity: Belongs to the GBP family. Atlastin subfamily |
Function
for ATL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ATLA3_HUMAN, Q6DD88Function: GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion ofendoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesisEnzyme Number (IUBMB): EC 3.6.5.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATL3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATL3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ATL3 (NM_015459) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATL3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATL3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ATL3 for ontologies About GeneDecksing
|
Pathways & Interactions
for ATL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATL3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for ATL3 (Q6DD882, 3 ENSP000003818444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
ATL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ATL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ATL3
Search CenterWatch for drugs/clinical trials and news about ATL3 / ATLA3
|
Transcripts
for ATL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATL3 gene: NM_015459.3 Unigene Cluster for ATL3: Atlastin GTPase 3 Hs.356719 [show with all ESTs]Unigene Representative Sequence: CR9367845 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398868(uc001nxk.1) ENST00000538786 ENST00000540699(uc001nxl.1)
ENST00000535789 ENST00000332645(uc010rmr.1 uc010rms.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATL3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATL3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ATL3 (NM_015459) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATL3 |
Additional cDNA sequence: AK023383.1 AK090822.1 AK094227.1 AK097588.1 AK301910.1 AL117600.1 BC077727.1 BX648468.1 CR936784.1 16 DOTS entries: DT.100813927 DT.100035958 DT.95373254 DT.75146147 DT.100813925 DT.91744011 DT.95309161 DT.100660679 DT.100669886 DT.211228 DT.92025976 DT.100785791 DT.121044751 DT.91763671 DT.92071310 DT.95377774 24/341 AceView cDNA sequences (see all 341): BM479185 BQ778407 BG035131 BE855467 BM127314 BE855813 AA256762 AI890798 CB127749 BG943904 AA427793 AL598083 BU631416 AW072940 AK023383 BQ575966 AK097588 CA441000 BM127617 AW028844 BQ955874 BM710779 CK906206 AW407580
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ATL3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ATL3
|
Expression
for ATL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ATL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATL3
SOURCE GeneReport for Unigene cluster: Hs.356719
UniProtKB/Swiss-Prot: ATLA3_HUMAN, Q6DD88Tissue specificity: Expressed in peripheral tissues (at protein level)
SABiosciences Custom PCR Arrays for ATL3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATL3 |
Orthologs
for ATL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ATL3 gene from 4/21 species (see all 21) About this table
ENSEMBL Gene Tree for ATL3 (if available)
TreeFam Gene Tree for ATL3 (if available) |
Paralogs
for ATL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATL3 gene
- RNF1122 ATL22 ATL12
3 SIMAP similar genes for ATL3 using alignment to 4 protein entries: ATLA3_HUMAN (see all proteins):ATL1 SPG3A ATL2
ATL3 for paralogs About GeneDecksing
|
Genomic Variants
for ATL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATL3 (63391559 - 63439393 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATL3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATL3 |
|
Disorders
/ Diseases
for ATL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATL3 for disorders About GeneDecksing
OMIM gene information: 609369
OMIM disorders: --
9  diseases for ATL3: About MalaCardsspastic paraplegia spastic paraplegia 3 spastic paraplegia 3a hereditary spastic paraplegia
paraplegia spasticity primary pulmonary hypertension pulmonary hypertension
hypertension
1 disease from the University of Copenhagen DISEASES database for ATL3:Primary pulmonary hypertension Export disorders for ATL3 gene to outside databases
|
Publications
for ATL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATL3 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with ATL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. (PubMed id 18270207)1, 2, 3 Rismanchi N.... Blackstone C. (2008)
- A class of dynamin-like GTPases involved in the generation of the tubular ER network. (PubMed id 19665976)1, 2 Hu J.... Blackstone C. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for ATL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ATL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATL3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ATL3 gene:
Search GeneIP for patents involving ATL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATL3 | | | OriGene Protein Over-expression Lysate for ATL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ATL3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ATL3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ATL3 | | OriGene Custom Protein Services for ATL3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATL3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ATL3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ATL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATL3 |
|  |  |  | | | | ThermoFisher Antibodies for ATL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATL3 |
|
|
|
|
