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Aliases for ATL2 Gene

Aliases for ATL2 Gene

  • Atlastin GTPase 2 2 3 5
  • ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 2 3 4
  • ADP-Ribosylation Factor-Like 6 Interacting Protein 2 2 3
  • ARL-6-Interacting Protein 2 3 4
  • ARL6IP2 3 4
  • Aip-2 3 4
  • ADP-Ribosylation-Like Factor 6 Interacting Protein 2 3
  • EC 3.6.5.- 4
  • Atlastin2 3
  • ARL3IP2 3

External Ids for ATL2 Gene

Previous HGNC Symbols for ATL2 Gene

  • ARL6IP2

Previous GeneCards Identifiers for ATL2 Gene

  • GC02M038375
  • GC02M038522
  • GC02M038262

Summaries for ATL2 Gene

GeneCards Summary for ATL2 Gene

ATL2 (Atlastin GTPase 2) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and GTPase activity. An important paralog of this gene is ATL3.

UniProtKB/Swiss-Prot for ATL2 Gene

  • GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATL2 Gene

Genomics for ATL2 Gene

Regulatory Elements for ATL2 Gene

Enhancers for ATL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATL2 on UCSC Golden Path with GeneCards custom track

Promoters for ATL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATL2 Gene

Chromosome:
2
Start:
38,294,094 bp from pter
End:
38,378,139 bp from pter
Size:
84,046 bases
Orientation:
Minus strand

Genomic View for ATL2 Gene

Genes around ATL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATL2 Gene

Proteins for ATL2 Gene

  • Protein details for ATL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHH9-ATLA2_HUMAN
    Recommended name:
    Atlastin-2
    Protein Accession:
    Q8NHH9
    Secondary Accessions:
    • B7Z1X2
    • B7Z7X8
    • Q4ZG30
    • Q7Z630
    • Q8NHH8
    • Q9H5M7

    Protein attributes for ATL2 Gene

    Size:
    583 amino acids
    Molecular mass:
    66229 Da
    Quaternary structure:
    • Interacts with REEP5 and RTN3.

    Alternative splice isoforms for ATL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATL2 Gene

Proteomics data for ATL2 Gene at MOPED

Post-translational modifications for ATL2 Gene

  • Ubiquitination at Lys 372 and Lys 567
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ATL2 Gene

Domains & Families for ATL2 Gene

Protein Domains for ATL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NHH9

UniProtKB/Swiss-Prot:

ATLA2_HUMAN :
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Domain:
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
genes like me logo Genes that share domains with ATL2: view

No data available for Gene Families for ATL2 Gene

Function for ATL2 Gene

Molecular function for ATL2 Gene

UniProtKB/Swiss-Prot Function:
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.

Enzyme Numbers (IUBMB) for ATL2 Gene

Gene Ontology (GO) - Molecular Function for ATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19665976
GO:0042802 identical protein binding IDA 18270207
genes like me logo Genes that share ontologies with ATL2: view

Phenotypes for ATL2 Gene

GenomeRNAi human phenotypes for ATL2:
genes like me logo Genes that share phenotypes with ATL2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATL2 Gene

Localization for ATL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATL2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATL2 Gene COMPARTMENTS Subcellular localization image for ATL2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA,IDA 18270207
genes like me logo Genes that share ontologies with ATL2: view

Pathways & Interactions for ATL2 Gene

SuperPathways for ATL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IMP 18270207
genes like me logo Genes that share ontologies with ATL2: view

No data available for Pathways by source and SIGNOR curated interactions for ATL2 Gene

Drugs & Compounds for ATL2 Gene

No Compound Related Data Available

Transcripts for ATL2 Gene

Unigene Clusters for ATL2 Gene

Atlastin GTPase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4:
SP5:
SP6: -

Relevant External Links for ATL2 Gene

GeneLoc Exon Structure for
ATL2
ECgene alternative splicing isoforms for
ATL2

Expression for ATL2 Gene

mRNA expression in normal human tissues for ATL2 Gene

Protein differential expression in normal tissues from HIPED for ATL2 Gene

This gene is overexpressed in Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATL2 Gene



SOURCE GeneReport for Unigene cluster for ATL2 Gene Hs.727652

mRNA Expression by UniProt/SwissProt for ATL2 Gene

Q8NHH9-ATLA2_HUMAN
Tissue specificity: Expressed in peripheral tissues (at protein level).
genes like me logo Genes that share expression patterns with ATL2: view

Protein tissue co-expression partners for ATL2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ATL2 Gene

Orthologs for ATL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATL2 35
  • 94.51 (n)
  • 96.91 (a)
ATL2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATL2 35
  • 95.77 (n)
  • 97.94 (a)
ATL2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atl2 35
  • 91.42 (n)
  • 97.77 (a)
Atl2 16
Atl2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATL2 35
  • 99.77 (n)
  • 99.49 (a)
ATL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atl2 35
  • 91.37 (n)
  • 96.74 (a)
oppossum
(Monodelphis domestica)
Mammalia ATL2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves ATL2 35
  • 81.33 (n)
  • 87.25 (a)
ATL2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATL2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atl2 35
  • 76.37 (n)
  • 85 (a)
Str.3803 35
zebrafish
(Danio rerio)
Actinopterygii atl2 35
  • 70.68 (n)
  • 76.32 (a)
wufv60d03 35
atl2 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002047 35
  • 57.6 (n)
  • 60.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta atl 35
  • 55.86 (n)
  • 57.37 (a)
atl 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.2 35
  • 55.26 (n)
  • 54.73 (a)
atln-1 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ATL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATL2 Gene

ENSEMBL:
Gene Tree for ATL2 (if available)
TreeFam:
Gene Tree for ATL2 (if available)

Paralogs for ATL2 Gene

Paralogs for ATL2 Gene

genes like me logo Genes that share paralogs with ATL2: view

Variants for ATL2 Gene

Sequence variations from dbSNP and Humsavar for ATL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3731847 - 38,377,209(-) GGCTG(A/C/T)GGCGC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs34873284 - 38,310,437(-) ACAAA(A/G)TCAAC nc-transcript-variant, reference, missense
rs7582826 - 38,298,518(+) GAGAT(C/G)CAAGT nc-transcript-variant, reference, missense
rs1806837 -- 38,301,020(+) ggctg(C/G)agtgc intron-variant
rs1806838 -- 38,301,141(+) aattt(C/T)gtatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATL2 Gene

Variant ID Type Subtype PubMed ID
nsv9646 CNV Loss 18304495
esv2719945 CNV Deletion 23290073
esv2176515 CNV Deletion 18987734
esv2675128 CNV Deletion 23128226

Variation tolerance for ATL2 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.30; 92.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATL2 Gene

Disorders for ATL2 Gene

Relevant External Links for ATL2

Genetic Association Database (GAD)
ATL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATL2

No disorders were found for ATL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATL2 Gene

Publications for ATL2 Gene

  1. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. (PMID: 18270207) Rismanchi N. … Blackstone C. (Hum. Mol. Genet. 2008) 2 3 4 67
  2. A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. (PMID: 10508919) Ingley E. … Klinken S.P. (FEBS Lett. 1999) 2 3
  3. Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes. (PMID: 25773277) Hu X. … Hu J. (Protein Cell 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ATL2 Gene

Sources for ATL2 Gene

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