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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATL2 Gene

protein-coding   GIFtS: 51
GCID: GC02M038522

atlastin GTPase 2

(Previous name: ADP-ribosylation factor-like 6 interacting protein 2 )
(Previous symbol: ARL6IP2)
 Explore 9 diseases affiliated with
ATL2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATL2    

Aliases
for ATL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Atlastin GTPase 21 2     ADP-Ribosylation-Like Factor 6 Interacting Protein 22
ARL6IP21 2 3     Aip-23
ADP-Ribosylation Factor-Like 6 Interacting Protein 21 2     Atlastin-21
ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 22 3     Atlastin21
ARL-6-Interacting Protein 22 3     Aip-23
ARL3IP22 5     EC 3.6.5.-3

External Ids:    HGNC: 240471   Entrez Gene: 642252   Ensembl: ENSG000001197877   OMIM: 6093685   UniProtKB: Q8NHH93   
ORGUL members:         
NONCODE:n406658    

Export aliases for ATL2 gene to outside databases

Previous GC identifers: GC02M038375 GC02M038262


Summaries
for ATL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
Function: GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of
endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis




Genomic Views
for ATL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATL2 gene promoter:
         AML1a   SREBP-1c   SREBP-1b   HNF-1A   CREB   SREBP-1a   FOXC1   HNF-1   c-Myb   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.3

ATL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M038522:  view genomic region     (about GC identifiers)

Start:
 38,522,022 bp from pter      End:
 38,604,432 bp from pter
Size:
 82,411 bases      Orientation:
 minus strand

Proteins
for ATL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9 (See protein sequence)
Recommended Name: Atlastin-2  
Size: 583 amino acids; 66229 Da
Subunit: Interacts with REEP5 and RTN3
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B7Z1X2 Q4ZG30 Q7Z630 Q8NHH8 Q9H5M7
Alternative splicing: 4 isoforms:  Q8NHH9-1   Q8NHH9-2   Q8NHH9-3   Q8NHH9-4   

Explore the universe of human proteins at neXtProt for ATL2: NX_Q8NHH9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NHH9

    • ATL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129145.1  NP_071769.2  

    ENSEMBL proteins: 
     ENSP00000368237   ENSP00000385446   ENSP00000384062   ENSP00000383944   ENSP00000415336  
     ENSP00000390743   ENSP00000409811   ENSP00000410592   ENSP00000413216   ENSP00000404921  
     ENSP00000406004   ENSP00000446192   ENSP00000333393   ENSP00000438938  

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    Novus Biologicals ATL2 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ATL2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18270207
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IDA18270207


    ATL2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ATL2

    Protein Domains /
    Families
    for ATL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATL2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003191 Guanylate-bd_C
     IPR015894 Guanylate-bd_N

    Graphical View of Domain Structure for InterPro Entry Q8NHH9

    ProtoNet protein and cluster: Q8NHH9

    UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
    Similarity: Belongs to the GBP family. Atlastin subfamily


    Function
    for ATL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
    Function: GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of
    endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis

    Enzyme Number (IUBMB): EC 3.6.5.-1

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate ATL2 (see all 48):
    hsa-miR-429 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-508-3p hsa-miR-374c hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: ATL2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for ATL2

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS18270207
    GO:0005515protein binding IPI19665976
    GO:0005525GTP binding IEA--
    GO:0042802identical protein binding IDA18270207


    ATL2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ATL2:
     Decreased viability with pacli  Synthetic lethal with Ras 


    Pathways & Interactions
    for ATL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ATL2 (Q8NHH91, 2, 3 ENSP000003682374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3295740 I2D: score=1 STRING: ENSP00000309503
    ARL6Q9H0F73, ENSP000003377224I2D: score=3 STRING: ENSP00000337722
    MUL1Q969V53I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    Reep5Q608701EBI-2559696,EBI-2410304
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS18270207
    GO:0006888NOT ER to Golgi vesicle-mediated transport IMP18270207
    GO:0007029endoplasmic reticulum organization IMP19665976
    GO:0007030Golgi organization IMP18270207
    GO:0051260protein homooligomerization IDA18270207


    ATL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATL2
    Search CenterWatch for drugs/clinical trials and news about ATL2 / ATLA2 

    Transcripts
    for ATL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATL2 gene (2 alternative transcripts): 
    NM_001135673.1  NM_022374.2  

    Unigene Cluster for ATL2:

    Atlastin GTPase 2
    Hs.727652  [show with all ESTs]
    Unigene Representative Sequence: NM_022374
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000378954(uc010ynm.2 uc010ynn.2 uc002rqq.3 uc002rqr.3 uc002rqs.3)
    ENST00000406122(uc010yno.2) ENST00000402054 ENST00000405384 ENST00000419554
    ENST00000452935 ENST00000477642 ENST00000489896 ENST00000449130 ENST00000443098
    ENST00000456736 ENST00000474535 ENST00000472097 ENST00000451483 ENST00000486927
    ENST00000416222 ENST00000539122 ENST00000332337

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATL2
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate ATL2 (see all 48):
    hsa-miR-429 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-508-3p hsa-miR-374c hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: ATL2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATL2 (see all 4)
    OriGene siRNA: ATL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATL2
    Clone
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    Additional cDNA sequence: 

    AK026946.1 AK124434.1 AK225190.1 AK294049.1 AK294711.1 AK302621.1 AK303985.1 AK308894.1 
    AK316179.1 BC039050.1 BC053508.1 NR_024191.1 

    9 DOTS entries:

    DT.85105471  DT.100790659  DT.75100632  DT.97801818  DT.95162968  DT.102829387  DT.100790663  DT.120996116 
    DT.40112315 

    24/156 AceView cDNA sequences (see all 156):

    AL524183 AA995615 CR617774 AI423009 N67297 AW276305 BC039050 BQ961517 
    BQ018123 CB161332 CB156791 AI540245 CA439221 BU173675 BQ001794 BM800502 
    BM052857 AA279230 BX507348 CA311772 AA481883 BF792832 AI619701 AA401775 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ATL2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                    -                       -                                         -                                 
    SP2:                    -     -                 -                                         -                       -         
    SP3:                    -           -     -     -     -                                                                     
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ATL2

    Expression
    for ATL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGTGTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ATL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyCap MesenchymeCap Mesenchyme CellsKidney
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See ATL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATL2

    SOURCE GeneReport for Unigene cluster: Hs.727652

    UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
    Tissue specificity: Expressed in peripheral tissues (at protein level)

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    In Situ
    Assay Products:     
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    Orthologs
    for ATL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ATL2 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008591171 atlastin-2-like 82.32(n)
    88.58(a)    		   100859117  XM_003640929.1  XP_003640977.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ATL26
    		 --
    		 86(a)
    		 1 ↔ 1
    		 1(254187903-254209951)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.38032 Transcribed sequence with moderate similarity to protein more 81.75(n)    142009368 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufv60d032 wufv60d03 77.51(n)   334573  CA470377.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta atl1 atlastin 56.02(n)
    57.94(a)    		   42934  NM_143017.2  NP_651274.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y54G2A.21 Protein Y54G2A.2 55.26(n)
    54.73(a)    		   177059  NM_001028321.1  NP_001023492.1 


    ENSEMBL Gene Tree for ATL2 (if available)
    TreeFam Gene Tree for ATL2 (if available) 

    Paralogs
    for ATL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATL2 gene
    RNF1122  ATL32  ATL12  
    18/94 SIMAP similar genes for ATL2 using alignment to 9 protein entries:     ATLA2_HUMAN (see all proteins) (see all similar genes):
    FAM3A    LAMA5    LGALS3    SUN3    CCPG1    COX7A2
    MKRN1    SCIMP    THADA    TMX3    C12orf23    UTY
    ZNF568    SPG3A    GBP3    NSD1    SENP7    WDR6

    ATL2 for paralogs           About GeneDecksing



    Genomic Variants
    for ATL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1740 NCBI SNPs in ATL2 are shown (see all 1740)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1872474751,2
    		--38521529(+) ACTTAA/TAATAG 3 -- int10--------
    rs1177770631,2
    		--38521532(+) TAAAAT/CAGAAA 3 -- int11Minor allele frequency- C:0.01EA 120
    rs763453971,2
    		F,--38521761(+) AAAAAT/CGCTAG 3 -- int11Minor allele frequency- C:0.09EA 120
    rs343887481,2
    		C--38521783(+) CCACC-/AAAAAA 3 -- int10--------
    rs601735491,2
    		C--38521796(+) AAAAAG/AAGAGA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs1916217511,2
    		--38521856(+) CCTTAA/TAGAGA 3 -- int10--------
    rs170225491,2
    		C,F,H,--38521908(+) TACAAT/CGCCTT 3 -- int126Minor allele frequency- C:0.20NA EA NS WA CSA 2688
    rs1419514381,2
    		--38521955(+) TTTCAC/TTATAA 3 -- int10--------
    rs1814523601,2
    		--38522092(+) AAAATC/GCAACA 3 -- ut31 nc-transcript-variant0--------
    rs2001941101,2
    		C--38522140(+) CTTGGG/TGNNNN 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for ATL2 (38522022 - 38604432 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ATL2
         1 CNV: 32298
         1 Indel: 46001

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    Disorders / Diseases
    for ATL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATL2 for disorders           About GeneDecksing

    OMIM gene information: 609368    OMIM disorders: --

    9 diseases for ATL2:    About MalaCards
    spastic paraplegia    spastic paraplegia 3    spastic paraplegia 3a    hereditary spastic paraplegia
    paraplegia    spasticity    adult t-cell leukemia    t-cell leukemia
    leukemia

    1 disease from the University of Copenhagen DISEASES database for ATL2:
    Adult T-cell leukemia

    Export disorders for ATL2 gene to outside databases

    Publications
    for ATL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATL2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ATL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. (PubMed id 18270207)1, 2, 3 Rismanchi N.... Blackstone C. (2008)
    2. A class of dynamin-like GTPases involved in the generation of the tubular ER network. (PubMed id 19665976)1, 2 Hu J.... Blackstone C. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. (PubMed id 10508919)1, 3 Ingley E....Klinken S.P. (1999)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. An intramolecular salt bridge drives the soluble doma in of GTP-bound atlastin into the postfusion conformation. (PubMed id 22065636)1 Morin-Leisk J....Lee T.H. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for ATL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
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    Genome Databases showing ATL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64225 HGNC: 24047 AceView: ARL6IP2 Ensembl:ENSG00000119787 euGenes: HUgn64225
    ECgene: ATL2 H-InvDB: ATL2

    Other Databases showing ATL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATL2 gene:
    Search GeneIP for patents involving ATL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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