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Aliases for ATL2 Gene

Aliases for ATL2 Gene

  • Atlastin GTPase 2 2 3
  • ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 2 3 4
  • ADP-Ribosylation Factor-Like 6 Interacting Protein 2 2 3
  • ARL-6-Interacting Protein 2 3 4
  • ARL6IP2 3 4
  • Aip-2 3 4
  • ADP-Ribosylation-Like Factor 6 Interacting Protein 2 3
  • Atlastin-2 3
  • EC 3.6.5.- 4
  • Atlastin2 3
  • ARL3IP2, 6
  • ARL3IP2 3

External Ids for ATL2 Gene

Previous Symbols for ATL2 Gene

  • ARL6IP2

Summaries for ATL2 Gene

GeneCards Summary for ATL2 Gene

ATL2 (Atlastin GTPase 2) is a Protein Coding gene. Diseases associated with ATL2 include spastic paraplegia 3a and spastic paraplegia 3. GO annotations related to this gene include identical protein binding and GTPase activity. An important paralog of this gene is ATL3.

UniProtKB/Swiss-Prot for ATL2 Gene

  • GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATL2 Gene

Genomics for ATL2 Gene

Genomic Location for ATL2 Gene

Start:
38,294,880 bp from pter
End:
38,378,173 bp from pter
Size:
83,294 bases
Orientation:
Minus strand

Genomic View for ATL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATL2 Gene

Regulatory Elements for ATL2 Gene

Proteins for ATL2 Gene

  • Protein details for ATL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHH9-ATLA2_HUMAN
    Recommended name:
    Atlastin-2
    Protein Accession:
    Q8NHH9
    Secondary Accessions:
    • B7Z1X2
    • B7Z7X8
    • Q4ZG30
    • Q7Z630
    • Q8NHH8
    • Q9H5M7

    Protein attributes for ATL2 Gene

    Size:
    583 amino acids
    Molecular mass:
    66229 Da
    Quaternary structure:
    • Interacts with REEP5 and RTN3.

    Alternative splice isoforms for ATL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATL2 Gene

Proteomics data for ATL2 Gene at MOPED

Post-translational modifications for ATL2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys270, Lys361, Lys372, and Lys567

No data available for DME Specific Peptides for ATL2 Gene

Domains for ATL2 Gene

Protein Domains for ATL2 Gene

UniProtKB/Swiss-Prot:

ATLA2_HUMAN
Domain:
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.:
    • Q8NHH9
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.:
    • Q8NHH9
genes like me logo Genes that share domains with ATL2: view

No data available for Gene Families for ATL2 Gene

Function for ATL2 Gene

Molecular function for ATL2 Gene

UniProtKB/Swiss-Prot Function: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.

Enzyme Numbers (IUBMB) for ATL2 Gene

Gene Ontology (GO) - Molecular Function for ATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 18270207
GO:0005515 protein binding IPI 19665976
GO:0005525 GTP binding IEA --
GO:0042802 identical protein binding IDA 18270207
genes like me logo Genes that share ontologies with ATL2: view

Phenotypes for ATL2 Gene

GenomeRNAi human phenotypes for ATL2:
genes like me logo Genes that share phenotypes with ATL2: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ATL2 Gene

Localization for ATL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATL2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATL2 Gene COMPARTMENTS Subcellular localization image for ATL2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 18270207
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IDA 18270207
genes like me logo Genes that share ontologies with ATL2: view

Pathways for ATL2 Gene

SuperPathways for ATL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006888 NOT ER to Golgi vesicle-mediated transport IMP 18270207
GO:0007029 endoplasmic reticulum organization IMP 18270207
GO:0007030 Golgi organization IMP 18270207
GO:0008152 metabolic process NAS 18270207
genes like me logo Genes that share ontologies with ATL2: view

No data available for Pathways by source for ATL2 Gene

Transcripts for ATL2 Gene

Unigene Clusters for ATL2 Gene

Atlastin GTPase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATL2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4:
SP5:
SP6: -

Relevant External Links for ATL2 Gene

GeneLoc Exon Structure for
ATL2
ECgene alternative splicing isoforms for
ATL2

Expression for ATL2 Gene

mRNA expression in normal human tissues for ATL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATL2 Gene

SOURCE GeneReport for Unigene cluster for ATL2 Gene Hs.727652

mRNA Expression by UniProt/SwissProt for ATL2 Gene

Q8NHH9-ATLA2_HUMAN
Tissue specificity: Expressed in peripheral tissues (at protein level).
genes like me logo Genes that share expressions with ATL2: view

Orthologs for ATL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATL2 36
  • 99.77 (n)
  • 99.49 (a)
ATL2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATL2 36
  • 94.51 (n)
  • 96.91 (a)
ATL2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATL2 36
  • 95.77 (n)
  • 97.94 (a)
ATL2 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atl2 36
  • 91.42 (n)
  • 97.77 (a)
Atl2 16
Atl2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATL2 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 90 (a)
OneToMany
-- 37
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Atl2 36
  • 91.37 (n)
  • 96.74 (a)
chicken
(Gallus gallus)
Aves ATL2 36
  • 81.33 (n)
  • 87.25 (a)
ATL2 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATL2 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atl2 36
  • 76.37 (n)
  • 85 (a)
Str.3803 36
zebrafish
(Danio rerio)
Actinopterygii atl2 36
  • 70.68 (n)
  • 76.32 (a)
atl2 37
  • 68 (a)
OneToOne
wufv60d03 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002047 36
  • 57.6 (n)
  • 60.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta atl 36
  • 55.86 (n)
  • 57.37 (a)
atl 37
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atln-1 37
  • 49 (a)
OneToMany
Y54G2A.2 36
  • 55.26 (n)
  • 54.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToMany
Species with no ortholog for ATL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATL2 Gene

ENSEMBL:
Gene Tree for ATL2 (if available)
TreeFam:
Gene Tree for ATL2 (if available)

Paralogs for ATL2 Gene

Paralogs for ATL2 Gene

genes like me logo Genes that share paralogs with ATL2: view

Variants for ATL2 Gene

Sequence variations from dbSNP and Humsavar for ATL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3632 -- 38,295,002(+) GTGGG(C/G)GGGGG utr-variant-3-prime, nc-transcript-variant
rs6987 -- 38,295,118(-) AGTAC(A/T)GTCCC utr-variant-3-prime, nc-transcript-variant
rs967940 -- 38,353,091(-) TGACT(A/G)TGGGC intron-variant
rs1022076 -- 38,316,907(+) CACAG(C/T)TGTGC intron-variant
rs1026087 -- 38,317,464(+) CCGGA(C/T)AGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATL2 Gene

Variant ID Type Subtype PubMed ID
nsv9646 CNV Loss 18304495
esv2719945 CNV Deletion 23290073
esv2176515 CNV Deletion 18987734
esv2675128 CNV Deletion 23128226

Relevant External Links for ATL2 Gene

HapMap Linkage Disequilibrium report
ATL2

Disorders for ATL2 Gene

(1) University of Copenhagen DISEASES for ATL2 Gene

Relevant External Links for ATL2

Genetic Association Database (GAD)
ATL2
genes like me logo Genes that share disorders with ATL2: view

No data available for UniProtKB/Swiss-Prot for ATL2 Gene

Publications for ATL2 Gene

  1. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. (PMID: 18270207) Rismanchi N. … Blackstone C. (Hum. Mol. Genet. 2008) 2 3 4
  2. A class of dynamin-like GTPases involved in the generation of the tubular ER network. (PMID: 19665976) Hu J. … Blackstone C. (Cell 2009) 3 4
  3. A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. (PMID: 10508919) Ingley E. … Klinken S.P. (FEBS Lett. 1999) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Early onset autosomal dominant spastic paraplegia caused by novel mutations in SPG3A. (PMID: 15517445) Abel A. … Hazan J. (Neurogenetics 2004) 3

Products for ATL2 Gene

Sources for ATL2 Gene

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