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ATL2 Gene

protein-coding   GIFtS: 51
GCID: GC02M038522

Atlastin GTPase 2

(Previous name: ADP-ribosylation factor-like 6 interacting protein 2)
(Previous symbol: ARL6IP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Atlastin GTPase 21 2     ADP-Ribosylation-Like Factor 6 Interacting Protein 22
ARL6IP21 2 3     aip-22
ADP-Ribosylation Factor-Like 6 Interacting Protein 21 2     atlastin-22
ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 22 3     atlastin22
ARL-6-Interacting Protein 22 3     Aip-23
ARL3IP22 5     EC 3.6.5.-3

External Ids:    HGNC: 240471   Entrez Gene: 642252   Ensembl: ENSG000001197877   OMIM: 6093685   UniProtKB: Q8NHH93   

Export aliases for ATL2 gene to outside databases

Previous GC identifers: GC02M038375 GC02M038262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATL2 Gene:
ATL2 (atlastin GTPase 2) is a protein-coding gene. Diseases associated with ATL2 include spastic paraplegia 3, and spastic paraplegia 3a. GO annotations related to this gene include GTPase activity and identical protein binding. An important paralog of this gene is RNF112.

UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
Function: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of
endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ATL2 gene promoter:
         AML1a   SREBP-1c   SREBP-1b   HNF-1A   CREB   SREBP-1a   FOXC1   HNF-1   c-Myb   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATL2 promoter sequence
   Search Chromatin IP Primers for ATL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.3

ATL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M038522:  view genomic region     (about GC identifiers)

Start:
38,522,022 bp from pter      End:
38,604,432 bp from pter
Size:
82,411 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9 (See protein sequence)
Recommended Name: Atlastin-2  
Size: 583 amino acids; 66229 Da
Subunit: Interacts with REEP5 and RTN3
Secondary accessions: B7Z1X2 Q4ZG30 Q7Z630 Q8NHH8 Q9H5M7
Alternative splicing: 4 isoforms:  Q8NHH9-1   Q8NHH9-2   Q8NHH9-3   Q8NHH9-4   

Explore the universe of human proteins at neXtProt for ATL2: NX_Q8NHH9

Explore proteomics data for ATL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys270, Lys361, Lys372, Lys567
  • Modification sites at PhosphoSitePlus

  • See ATL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129145.1  NP_071769.2  

    ENSEMBL proteins: 
     ENSP00000368237   ENSP00000385446   ENSP00000384062   ENSP00000383944   ENSP00000415336  
     ENSP00000390743   ENSP00000409811   ENSP00000410592   ENSP00000413216   ENSP00000404921  
     ENSP00000406004   ENSP00000446192   ENSP00000333393   ENSP00000438938  

    ATL2 Human Recombinant Protein Products:

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    Novus Biologicals ATL2 Protein
    Novus Biologicals ATL2 Lysate
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    Cloud-Clone Corp. Proteins for ATL2

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    Cloud-Clone Corp. CLIAs for ATL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015894 Guanylate-bd_N
     IPR027417 P-loop_NTPase
     IPR003191 Guanylate-bd_C

    Graphical View of Domain Structure for InterPro Entry Q8NHH9

    ProtoNet protein and cluster: Q8NHH9

    UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
    Similarity: Belongs to the GBP family. Atlastin subfamily


    ATL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATLA2_HUMAN, Q8NHH9
    Function: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of
    endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis

         Enzyme Number (IUBMB): EC 3.6.5.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS18270207
    GO:0005515protein binding IPI19665976
    GO:0005525GTP binding IEA--
    GO:0042802identical protein binding IDA18270207
         
    ATL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ATL2:
     Decreased viability with pacli  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATL2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATL2:
    hsa-mir-186-5p (MIRT021152), hsa-mir-16-5p (MIRT031714), hsa-mir-125a-5p (MIRT021317), hsa-mir-30a-5p (MIRT028540), hsa-mir-155-5p (MIRT020733), hsa-mir-484 (MIRT042321), hsa-mir-221-3p (MIRT024158)

    Block miRNA regulation of human, mouse, rat ATL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATL2 (see all 48):
    hsa-miR-429 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-508-3p hsa-miR-374c hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidATL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ATL2
    Predesigned siRNA for gene silencing in human, mouse, rat ATL2

    Gene Editing
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    OriGene clones in human, mouse for ATL2 (see all 13)
    OriGene ORF clones in mouse, rat for ATL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATL2 (NM_022374)
    Sino Biological Human cDNA Clone for ATL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATL2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATLA2_HUMAN, Q8NHH9: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18270207
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IDA18270207

    ATL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATL2
    Interactions:

        Search GeneGlobe Interaction Network for ATL2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for ATL2 (Q8NHH91, 2, 3 ENSP000003682374) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3295740 I2D: score=1 STRING: ENSP00000309503
    ARL6Q9H0F73, ENSP000003377224I2D: score=3 STRING: ENSP00000337722
    MUL1Q969V53I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    ARRDC3ENSP000002651384STRING: ENSP00000265138
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS18270207
    GO:0006888NOT ER to Golgi vesicle-mediated transport IMP18270207
    GO:0007029endoplasmic reticulum organization IMP18270207
    GO:0007030Golgi organization IMP18270207
    GO:0051260protein homooligomerization IDA18270207

    ATL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATL2 (ATLA2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATL2 gene (2 alternative transcripts): 
    NM_001135673.1  NM_022374.2  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000378954(uc010ynm.2 uc010ynn.2 uc002rqq.3 uc002rqr.3 uc002rqs.3)
    ENST00000406122(uc010yno.2) ENST00000402054 ENST00000405384 ENST00000419554
    ENST00000452935 ENST00000477642 ENST00000489896 ENST00000449130 ENST00000443098
    ENST00000456736 ENST00000474535 ENST00000472097 ENST00000451483 ENST00000486927
    ENST00000416222 ENST00000539122 ENST00000332337
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATL2 (see all 48):
    hsa-miR-429 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-508-3p hsa-miR-374c hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidATL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATL2
    Predesigned siRNA for gene silencing in human, mouse, rat ATL2
    Clone
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    OriGene clones in human, mouse for ATL2 (see all 13)
    OriGene ORF clones in mouse, rat for ATL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATL2 (NM_022374)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATL2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ATL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATL2
      QuantiTect SYBR Green Assays in human, mouse, rat ATL2
      QuantiFast Probe-based Assays in human, mouse, rat ATL2

    Selected AceView cDNA sequences (see all 156):

    N67297 BU173675 AL524183 CB156791 CB161332 BQ001794 CA311772 CB143121 
    BQ961517 AI471211 BX953845 AA279230 N22218 AA482064 BM800502 AI421737 
    BX507348 BX100110 AU253895 AI540245 BQ018123 BC039050 BM052857 BF792832 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATL2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                    -                       -                                         -                                 
    SP2:                    -     -                 -                                         -                       -         
    SP3:                    -           -     -     -     -                                                                     
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ATL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGTGTGTG
    ATL2 Expression
    About this image

    ATL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATL2 Protein Expression

    UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
    Tissue specificity: Expressed in peripheral tissues (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atl21 , 5 atlastin GTPase 21, 5 91.42(n)1
    97.77(a)1
      17 (50.30 cM)5
    562981  NM_019717.31  NP_062691.31 
     798483925 
    chicken
    (Gallus gallus)
    Aves ATL21 atlastin GTPase 2 81.33(n)
    87.25(a)
      100859117  XM_003640929.2  XP_003640977.2 
    lizard
    (Anolis carolinensis)
    Reptilia ATL26
    atlastin GTPase 2
    85(a)
    1 ↔ 1
    1(254158169-254213313)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.38032 Transcribed sequence with moderate similarity to protein more 81.75(n)    142009368 
    zebrafish
    (Danio rerio)
    Actinopterygii wufv60d032 wufv60d03 77.51(n)   334573  CA470377.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta atl1 atlastin 55.86(n)
    57.37(a)
      42934  NM_170157.1  NP_733020.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54G2A.21 Y54G2A.2 55.26(n)
    54.73(a)
      177059  NM_001028321.2  NP_001023492.1 


    ENSEMBL Gene Tree for ATL2 (if available)
    TreeFam Gene Tree for ATL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATL2 gene
    RNF1122  ATL32  ATL12  
    Selected SIMAP similar genes for ATL2 using alignment to 9 protein entries:     ATLA2_HUMAN (see all proteins) (see all similar genes):
    ASB9    FAM3A    LAMA5    LGALS3    SUN3    CCPG1
    COX7A2    MKRN1    SCIMP    THADA    TMX3    C12orf23
    UTY    ZNF568    SPG3A    GBP3    NSD1    SENP7

    ATL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATL2 (see all 2246)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872474751,2
    --38521529(+) ACTTAA/TAATAG 3 -- int10--------
    rs1177770631,2
    F--38521532(+) TAAAAT/CAGAAA 3 -- int11Minor allele frequency- C:0.01EA 120
    rs763453971,2
    C,F--38521761(+) AAAAAT/CGCTAG 3 -- int11Minor allele frequency- C:0.09EA 120
    rs343887481,2
    C--38521783(+) CCACC-/AAAAAA 3 -- int10--------
    rs601735491,2
    C--38521796(+) AAAAAG/AAGAGA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs1916217511,2
    --38521856(+) CCTTAA/TAGAGA 3 -- int10--------
    rs170225491,2
    C,F,H--38521908(+) TACAAT/CGCCTT 3 -- int126Minor allele frequency- C:0.20NA EA NS WA CSA 2688
    rs1419514381,2
    --38521955(+) TTTCAC/TTATAA 3 -- int10--------
    rs1814523601,2
    --38522092(+) AAAATC/GCAACA 3 -- ut31 nc-transcript-variant0--------
    rs2001941101,2
    C--38522140(+) CTTGGG/TGNNNN 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for ATL2 (38522022 - 38604432 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ATL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2176515CNV Deletion18987734
    esv2719945CNV Deletion23290073
    esv2675128CNV Deletion23128226
    nsv9646CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ATL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ATL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609368    OMIM disorders: --

    9 diseases for ATL2:    
    About MalaCards
    spastic paraplegia 3    spastic paraplegia 3a    hereditary spastic paraplegia    paraplegia
    spasticity    adult t-cell leukemia    t-cell leukemia    leukemia
    malaria

    1 disease from the University of Copenhagen DISEASES database for ATL2:
    Adult T-cell leukemia

    ATL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATL2

    Export disorders for ATL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATL2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ATL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. (PubMed id 18270207)1, 2, 3 Rismanchi N.... Blackstone C. (Hum. Mol. Genet. 2008)
    2. A class of dynamin-like GTPases involved in the generation of the tubular ER network. (PubMed id 19665976)1, 2 Hu J.... Blackstone C. (Cell 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. (PubMed id 10508919)1, 3 Ingley E....Klinken S.P. (FEBS Lett. 1999)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. An intramolecular salt bridge drives the soluble domain of GTP-bound atlastin into the postfusion conformation. (PubMed id 22065636)1 Morin-Leisk J....Lee T.H. (J. Cell Biol. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64225 HGNC: 24047 AceView: ARL6IP2 Ensembl:ENSG00000119787 euGenes: HUgn64225
    ECgene: ATL2 H-InvDB: ATL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATL2 gene:
    Search GeneIP for patents involving ATL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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