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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATL2 Gene

protein-coding   GIFtS: 53
GCID: GC02M038522

Atlastin GTPase 2

(Previous name: ADP-ribosylation factor-like 6 interacting protein 2)
(Previous symbol: ARL6IP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Atlastin GTPase 21 2     ADP-Ribosylation-Like Factor 6 Interacting Protein 22
ARL6IP21 2 3     aip-22
ADP-Ribosylation Factor-Like 6 Interacting Protein 21 2     atlastin-22
ADP-Ribosylation Factor-Like Protein 6-Interacting Protein 22 3     atlastin22
ARL-6-Interacting Protein 22 3     Aip-23
ARL3IP22 5     EC 3.6.5.-3

External Ids:    HGNC: 240471   Entrez Gene: 642252   Ensembl: ENSG000001197877   OMIM: 6093685   UniProtKB: Q8NHH93   
ORGUL members:         
NONCODE14:n406658      

Export aliases for ATL2 gene to outside databases

Previous GC identifers: GC02M038375 GC02M038262


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ATL2 Gene: 
ATL2 (atlastin GTPase 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ATL2 include spastic paraplegia 3a, and spastic paraplegia 3. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RNF112.

UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
Function: GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of
endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATL2 gene promoter:
         AML1a   SREBP-1c   SREBP-1b   HNF-1A   CREB   SREBP-1a   FOXC1   HNF-1   c-Myb   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.3

ATL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M038522:  view genomic region     (about GC identifiers)

Start:
38,522,022 bp from pter      End:
38,604,432 bp from pter
Size:
82,411 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9 (See protein sequence)
Recommended Name: Atlastin-2  
Size: 583 amino acids; 66229 Da
Subunit: Interacts with REEP5 and RTN3
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B7Z1X2 Q4ZG30 Q7Z630 Q8NHH8 Q9H5M7
Alternative splicing: 4 isoforms:  Q8NHH9-1   Q8NHH9-2   Q8NHH9-3   Q8NHH9-4   

Explore the universe of human proteins at neXtProt for ATL2: NX_Q8NHH9

Explore proteomics data for ATL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NHH9

  • ATL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATL2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129145.1  NP_071769.2  

    ENSEMBL proteins: 
     ENSP00000368237   ENSP00000385446   ENSP00000384062   ENSP00000383944   ENSP00000415336  
     ENSP00000390743   ENSP00000409811   ENSP00000410592   ENSP00000413216   ENSP00000404921  
     ENSP00000406004   ENSP00000446192   ENSP00000333393   ENSP00000438938  

    Human Recombinant Protein Products for ATL2: 
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    Novus Biologicals ATL2 Protein
    Novus Biologicals ATL2 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATL2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA18270207
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IDA18270207

    ATL2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR003191 Guanylate-bd_C
     IPR015894 Guanylate-bd_N

    Graphical View of Domain Structure for InterPro Entry Q8NHH9

    ProtoNet protein and cluster: Q8NHH9

    UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
    Similarity: Belongs to the GBP family. Atlastin subfamily


    ATL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATLA2_HUMAN, Q8NHH9
    Function: GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of
    endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis

         Enzyme Number (IUBMB): EC 3.6.5.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity NAS18270207
    GO:0005515protein binding IPI19665976
    GO:0005525GTP binding IEA--
    GO:0042802identical protein binding IDA18270207
         
    ATL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ATL2:
     Decreased viability with pacli  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ATL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ATL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATL2 
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    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate ATL2 (see all 48):
    hsa-miR-429 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-508-3p hsa-miR-374c hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidATL2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ATL2 (Q8NHH91, 2, 3 ENSP000003682374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3295740 I2D: score=1 STRING: ENSP00000309503
    ARL6Q9H0F73, ENSP000003377224I2D: score=3 STRING: ENSP00000337722
    MUL1Q969V53I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    Reep5Q608701EBI-2410430,EBI-2410304
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process NAS18270207
    GO:0006888NOT ER to Golgi vesicle-mediated transport IMP18270207
    GO:0007029endoplasmic reticulum organization IMP18270207
    GO:0007030Golgi organization IMP18270207
    GO:0051260protein homooligomerization IDA18270207

    ATL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATL2 (ATLA2)

    Search CenterWatch for drugs/clinical trials and news about ATL2 / ATLA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATL2 gene (2 alternative transcripts): 
    NM_001135673.1  NM_022374.2  

    Unigene Cluster for ATL2:

    Atlastin GTPase 2
    Hs.727652  [show with all ESTs]
    Unigene Representative Sequence: NM_022374
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000378954(uc010ynm.2 uc010ynn.2 uc002rqq.3 uc002rqr.3 uc002rqs.3)
    ENST00000406122(uc010yno.2) ENST00000402054 ENST00000405384 ENST00000419554
    ENST00000452935 ENST00000477642 ENST00000489896 ENST00000449130 ENST00000443098
    ENST00000456736 ENST00000474535 ENST00000472097 ENST00000451483 ENST00000486927
    ENST00000416222 ENST00000539122 ENST00000332337
    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate ATL2 (see all 48):
    hsa-miR-429 hsa-miR-139-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-508-3p hsa-miR-374c hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidATL2 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATL2
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    Additional mRNA sequence: 

    AK026946.1 AK124434.1 AK225190.1 AK294049.1 AK294711.1 AK302621.1 AK303985.1 AK308894.1 
    AK316179.1 BC039050.1 BC053508.1 NR_024191.1 

    9 DOTS entries:

    DT.85105471  DT.100790659  DT.75100632  DT.97801818  DT.95162968  DT.102829387  DT.100790663  DT.120996116 
    DT.40112315 

    24/156 AceView cDNA sequences (see all 156):

    BQ001794 CB161332 BX953845 AI471211 CB143121 AL524183 AI423009 AW276305 
    BQ961517 BQ018123 BX507348 BM800502 BM052857 CA311772 AA481883 AA279230 
    BF792832 AI619701 N22218 AU253895 AA482064 AI421737 BX100110 AA401775 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ATL2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                    -                       -                                         -                                 
    SP2:                    -     -                 -                                         -                       -         
    SP3:                    -           -     -     -     -                                                                     
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ATL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATL2 expression in normal human tissues (normalized intensities)      ATL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGTGTGTG
    ATL2 Expression
    About this image


    ATL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Pancreas (Endocrine System)
             visceral organ/gut/foregut-midgut junction   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Cartilage (Muscoskeletal System)
             fetal cartilage   

     -- (Gastrointestinal Tract)
             visceral organ/oral region/gland   

    See ATL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATL2

    SOURCE GeneReport for Unigene cluster: Hs.727652

    UniProtKB/Swiss-Prot: ATLA2_HUMAN, Q8NHH9
    Tissue specificity: Expressed in peripheral tissues (at protein level)

        SABiosciences Custom PCR Arrays for ATL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ATL2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atl21 , 5 atlastin GTPase 21, 5 91.42(n)1
    97.77(a)1
      17 (50.30 cM)5
    562981  NM_019717.21  NP_062691.31 
     798483925 
    chicken
    (Gallus gallus)
    Aves LOC1008591171 atlastin-2-like 82.32(n)
    88.58(a)
      100859117  XM_003640929.1  XP_003640977.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATL26
    atlastin GTPase 2
    83(a)
    1 ↔ 1
    1(254158169-254213313)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.38032 Transcribed sequence with moderate similarity to protein more 81.75(n)    142009368 
    zebrafish
    (Danio rerio)
    Actinopterygii wufv60d032 wufv60d03 77.51(n)   334573  CA470377.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta atl1 atlastin 56.02(n)
    57.94(a)
      42934  NM_143017.2  NP_651274.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54G2A.21 Protein Y54G2A.2 55.26(n)
    54.73(a)
      177059  NM_001028321.1  NP_001023492.1 


    ENSEMBL Gene Tree for ATL2 (if available)
    TreeFam Gene Tree for ATL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATL2 gene
    RNF1122  ATL32  ATL12  
    18/106 SIMAP similar genes for ATL2 using alignment to 9 protein entries:     ATLA2_HUMAN (see all proteins) (see all similar genes):
    ASB9    FAM3A    LAMA5    LGALS3    SUN3    CCPG1
    COX7A2    MKRN1    SCIMP    THADA    TMX3    C12orf23
    UTY    ZNF568    SPG3A    GBP3    NSD1    SENP7

    ATL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2246 SNPs in ATL2 are shown (see all 2246)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872474751,2
    --38521529(+) ACTTAA/TAATAG 3 -- int10--------
    rs1177770631,2
    F--38521532(+) TAAAAT/CAGAAA 3 -- int11Minor allele frequency- C:0.01EA 120
    rs763453971,2
    C,F--38521761(+) AAAAAT/CGCTAG 3 -- int11Minor allele frequency- C:0.09EA 120
    rs343887481,2
    C--38521783(+) CCACC-/AAAAAA 3 -- int10--------
    rs601735491,2
    C--38521796(+) AAAAAG/AAGAGA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs1916217511,2
    --38521856(+) CCTTAA/TAGAGA 3 -- int10--------
    rs170225491,2
    C,F,H--38521908(+) TACAAT/CGCCTT 3 -- int126Minor allele frequency- C:0.20NA EA NS WA CSA 2688
    rs1419514381,2
    --38521955(+) TTTCAC/TTATAA 3 -- int10--------
    rs1814523601,2
    --38522092(+) AAAATC/GCAACA 3 -- ut31 nc-transcript-variant0--------
    rs2001941101,2
    C--38522140(+) CTTGGG/TGNNNN 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for ATL2 (38522022 - 38604432 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ATL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2176515CNV Deletion18987734
    esv2719945CNV Deletion23290073
    esv2675128CNV Deletion23128226
    nsv9646CNV Loss18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609368    OMIM disorders: --

    8 diseases for ATL2:    About MalaCards
    spastic paraplegia 3a    spastic paraplegia 3    paraplegia    hereditary spastic paraplegia
    spasticity    adult t-cell leukemia    t-cell leukemia    leukemia

    1 disease from the University of Copenhagen DISEASES database for ATL2:
    Adult T-cell leukemia

    ATL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATL2

    Export disorders for ATL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATL2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ATL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. (PubMed id 18270207)1, 2, 3 Rismanchi N.... Blackstone C. (2008)
    2. A class of dynamin-like GTPases involved in the generation of the tubular ER network. (PubMed id 19665976)1, 2 Hu J.... Blackstone C. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. (PubMed id 10508919)1, 3 Ingley E....Klinken S.P. (1999)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. An intramolecular salt bridge drives the soluble doma in of GTP-bound atlastin into the postfusion conformation. (PubMed id 22065636)1 Morin-Leisk J....Lee T.H. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64225 HGNC: 24047 AceView: ARL6IP2 Ensembl:ENSG00000119787 euGenes: HUgn64225
    ECgene: ATL2 H-InvDB: ATL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATL2 gene:
    Search GeneIP for patents involving ATL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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