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Aliases for ATG9B Gene

Aliases for ATG9B Gene

  • Autophagy Related 9B 2 3
  • NOS3AS 3 4 6
  • APG9L2 3 4 6
  • Nitric Oxide Synthase 3-Overlapping Antisense Gene Protein 3 4
  • APG9-Like 2 3 4
  • SONE 3 6
  • ATG9 Autophagy Related 9 Homolog B (S. Cerevisiae) 2
  • Endothelial Nitric Oxide Synthase Antisense 3
  • ATG9 Autophagy Related 9 Homolog B 3
  • Nitric Oxide Synthase 3 Antisense 2
  • Autophagy-Related Protein 9B 3
  • Autophagy 9-Like 2 Protein 3
  • Protein SONE 4

External Ids for ATG9B Gene

Previous HGNC Symbols for ATG9B Gene

  • NOS3AS

Previous GeneCards Identifiers for ATG9B Gene

  • GC07U901563
  • GC07M150170
  • GC07M150340
  • GC07M150710
  • GC07M144521

Summaries for ATG9B Gene

Entrez Gene Summary for ATG9B Gene

  • This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for ATG9B Gene

ATG9B (Autophagy Related 9B) is a Protein Coding gene. An important paralog of this gene is ATG9A.

UniProtKB/Swiss-Prot for ATG9B Gene

  • Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG9B Gene

Genomics for ATG9B Gene

Regulatory Elements for ATG9B Gene

Genomic Location for ATG9B Gene

151,012,209 bp from pter
151,024,499 bp from pter
12,291 bases
Minus strand

Genomic View for ATG9B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG9B Gene

Proteins for ATG9B Gene

  • Protein details for ATG9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Autophagy-related protein 9B
    Protein Accession:
    Secondary Accessions:
    • A1A5D3
    • Q6JRW5
    • Q8N8I8

    Protein attributes for ATG9B Gene

    924 amino acids
    Molecular mass:
    101019 Da
    Quaternary structure:
    No Data Available
    • ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36. The genes are oriented in a tail-to-tail configuration and the mRNAs encoding ATG9B and NOS3 are complementary for 662 nucleotides. ATG9B transcription may a role in NOS3 transcription regulation
    • Sequence=AAQ86941.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AC010973; Type=Frameshift; Positions=766; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG9B Gene


neXtProt entry for ATG9B Gene

Proteomics data for ATG9B Gene at MOPED

Post-translational modifications for ATG9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG9B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ATG9B Gene

Domains for ATG9B Gene

Gene Families for ATG9B Gene

Protein Domains for ATG9B Gene


Suggested Antigen Peptide Sequences for ATG9B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATG9 family.
  • Belongs to the ATG9 family.
genes like me logo Genes that share domains with ATG9B: view

Function for ATG9B Gene

Molecular function for ATG9B Gene

UniProtKB/Swiss-Prot Function:
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity).
UniProtKB/Swiss-Prot Induction:
By hypoxia, leading to inhibit NOS3 expression.

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG9B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATG9B Gene

Localization for ATG9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG9B Gene

Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1 and ATG13.

Subcellular locations from

Jensen Localization Image for ATG9B Gene COMPARTMENTS Subcellular localization image for ATG9B gene
Compartment Confidence
vacuole 5
plasma membrane 3
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ATG9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagic vacuole membrane IEA --
GO:0005737 cytoplasm --
GO:0005776 autophagic vacuole --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ATG9B: view

Pathways for ATG9B Gene

SuperPathways for ATG9B Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ATG9B Gene

Selected Interacting proteins: Q674R7-ATG9B_HUMAN for ATG9B Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ATG9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IDA 15755735
GO:0006914 autophagy --
genes like me logo Genes that share ontologies with ATG9B: view

No data available for Pathways by source for ATG9B Gene

Transcripts for ATG9B Gene

mRNA/cDNA for ATG9B Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATG9B Gene

Autophagy related 9B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG9B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG9B Gene

No ASD Table

Relevant External Links for ATG9B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG9B Gene

mRNA expression in normal human tissues for ATG9B Gene

mRNA differential expression in normal tissues according to GTEx for ATG9B Gene

This gene is overexpressed in Esophagus - Mucosa (12.5), Skin - Not Sun Exposed (Suprapubic) (5.9), Skin - Sun Exposed (Lower leg) (5.7), Pituitary (5.2), Vagina (4.9), Cervix - Ectocervix (4.5), and Testis (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ATG9B Gene

SOURCE GeneReport for Unigene cluster for ATG9B Gene Hs.707300

mRNA Expression by UniProt/SwissProt for ATG9B Gene

Tissue specificity: Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.
genes like me logo Genes that share expressions with ATG9B: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Expression partners for ATG9B Gene

Orthologs for ATG9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG9B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATG9B 35
  • 86.11 (n)
  • 84.74 (a)
ATG9B 36
  • 74 (a)
(Canis familiaris)
Mammalia ATG9B 35
  • 87.18 (n)
  • 86.22 (a)
(Mus musculus)
Mammalia Atg9b 35
  • 85.58 (n)
  • 87.18 (a)
Atg9b 16
Atg9b 36
  • 86 (a)
(Pan troglodytes)
Mammalia ATG9B 35
  • 99.46 (n)
  • 99.35 (a)
ATG9B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Atg9b 35
  • 84.95 (n)
  • 87.21 (a)
(Monodelphis domestica)
Mammalia ATG9B 36
  • 70 (a)
(Anolis carolinensis)
Reptilia ATG9B 36
  • 48 (a)
(Danio rerio)
Actinopterygii atg9b 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atg9 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea atg-9 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG9 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2027 36
  • 43 (a)
Species with no ortholog for ATG9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATG9B Gene

Gene Tree for ATG9B (if available)
Gene Tree for ATG9B (if available)

Paralogs for ATG9B Gene

Paralogs for ATG9B Gene

(1) SIMAP similar genes for ATG9B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATG9B: view

Variants for ATG9B Gene

Sequence variations from dbSNP and Humsavar for ATG9B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1077871 -- 151,017,557(+) CCCAC(C/T)GGCCA intron-variant
rs1077872 -- 151,017,659(+) TGTGT(C/G)TTCAC intron-variant
rs1835428 -- 151,018,730(+) AGTGC(A/G)CCCGC synonymous-codon, reference, intron-variant
rs2373928 -- 151,021,938(-) ggcgt(A/G)gtggc intron-variant
rs2373929 -- 151,017,725(-) GTGCC(C/T)TCGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG9B Gene

Variant ID Type Subtype PubMed ID
dgv7544n71 CNV Loss 21882294
nsv889465 CNV Loss 21882294
nsv889469 CNV Gain 21882294
nsv889471 CNV Loss 21882294
nsv889473 CNV Loss 21882294
nsv889474 CNV Loss 21882294
nsv526410 CNV Loss 19592680
dgv1252e199 CNV Deletion 23128226

Relevant External Links for ATG9B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG9B Gene

Disorders for ATG9B Gene

Relevant External Links for ATG9B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ATG9B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ATG9B Gene

Publications for ATG9B Gene

  1. Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript. (PMID: 15234981) Robb G.B. … Marsden P.A. (J. Biol. Chem. 2004) 2 3 4 23
  2. Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast. (PMID: 15755735) Yamada T. … Scherer S.W. (J. Biol. Chem. 2005) 2 3 4
  3. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. (PMID: 19197948) Kang M.R. … Lee S.H. (J. Pathol. 2009) 3 48
  4. Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma. (PMID: 19423521) Han X. … Zhang Y. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 48
  5. Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase. (PMID: 17403686) Fish J.E. … Marsden P.A. (J. Biol. Chem. 2007) 3 4

Products for ATG9B Gene

Sources for ATG9B Gene

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