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ATG9B Gene

protein-coding   GIFtS: 42
GCID: GC07M150710

Autophagy Related 9B

(Previous names: nitric oxide synthase 3 antisense, ATG9 autophagy related...)
(Previous symbol: NOS3AS)
  See ATG9B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Autophagy Related 9B1 2     Nitric Oxide Synthase 3 Antisense1
NOS3AS1 2 3 5     ATG9 Autophagy Related 9 Homolog B2
APG9L22 3 5     Autophagy 9-Like 2 Protein2
Nitric Oxide Synthase 3-Overlapping Antisense Gene Protein2 3     Autophagy-Related Protein 9B2
APG9-Like 22 3     Endothelial Nitric Oxide Synthase Antisense2
SONE2 5     Protein SONE3
ATG9 Autophagy Related 9 Homolog B (S. Cerevisiae)1     

External Ids:    HGNC: 218991   Entrez Gene: 2859732   Ensembl: ENSG000001816527   OMIM: 6122055   UniProtKB: Q674R73   

Export aliases for ATG9B gene to outside databases

Previous GC identifers: GC07U901563 GC07M150170 GC07M150340 GC07M144521


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATG9B Gene:
This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as
an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene,
which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the
autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Sep 2012)

GeneCards Summary for ATG9B Gene:
ATG9B (autophagy related 9B) is a protein-coding gene. Diseases associated with ATG9B include non-hodgkin lymphoma. An important paralog of this gene is ATG9A.

UniProtKB/Swiss-Prot: ATG9B_HUMAN, Q674R7
Function: Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in
the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for
formation of the sequestering vesicle (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ATG9B gene promoter:
         AREB6   USF-1   Lmo2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Pax-4a   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG9B promoter sequence
   Search Chromatin IP Primers for ATG9B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATG9B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

ATG9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG9B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150710:  view genomic region     (about GC identifiers)

Start:
150,709,297 bp from pter      End:
150,721,586 bp from pter
Size:
12,290 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,038,886-150,051,176     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ATG9B_HUMAN, Q674R7 (See protein sequence)
Recommended Name: Autophagy-related protein 9B  
Size: 924 amino acids; 101019 Da
Miscellaneous: ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36. The genes are
oriented in a tail-to-tail configuration and the mRNAs encoding ATG9B and NOS3 are complementary for 662
nucleotides. ATG9B transcription may a role in NOS3 transcription regulation
Sequence caution: Sequence=AAQ86941.1; Type=Erroneous initiation; Sequence=AC010973; Type=Frameshift;
Positions=766;
Secondary accessions: A1A5D3 Q6JRW5 Q8N8I8
Alternative splicing: 3 isoforms:  Q674R7-1   Q674R7-2   Q674R7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATG9B: NX_Q674R7

Explore proteomics data for ATG9B at MOPED


See ATG9B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_775952.4  
ENSEMBL proteins: 
 ENSP00000475005   ENSP00000473897   ENSP00000475202   ENSP00000475737  

ATG9B Human Recombinant Protein Products:

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antibodies-online antibodies for ATG9B (40 products) 

ATG9B Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007241 Autophagy-rel_prot_9

Graphical View of Domain Structure for InterPro Entry Q674R7

ProtoNet protein and cluster: Q674R7

UniProtKB/Swiss-Prot: ATG9B_HUMAN, Q674R7
Similarity: Belongs to the ATG9 family


Find genes that share domains with ATG9B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ATG9B_HUMAN, Q674R7
Function: Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in
the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for
formation of the sequestering vesicle (By similarity)
Induction: By hypoxia, leading to inhibit NOS3 expression

Animal Models:

   genOway: Develop your customized and physiologically relevant rodent model for ATG9B

miRNA
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2 qRT-PCR Assays for microRNAs that regulate ATG9B:
hsa-miR-4316 hsa-miR-485-5p
SwitchGear 3'UTR luciferase reporter plasmidATG9B 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for ATG9B
Predesigned siRNA for gene silencing in human, mouse, rat ATG9B

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ATG9B_HUMAN, Q674R7: Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Under amino
acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed
peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1 and ATG13
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
vacuole5
plasma membrane3
cytosol1
mitochondrion1
nucleus1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000421autophagic vacuole membrane IEA--
GO:0005737cytoplasm ----
GO:0005776autophagic vacuole ----
GO:0016021integral component of membrane IEA--
GO:0031410cytoplasmic vesicle IEA--

Find genes that share ontologies with ATG9B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including ATG9B: 
          Autophagy in human mouse rat

Interactions:

    GeneGlobe Interaction Network for ATG9B

1 Interacting protein for ATG9B (Q674R73) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ATG16L1Q676U53I2D: score=1 
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000045autophagic vacuole assembly IDA15755735
GO:0006914autophagy ----

Find genes that share ontologies with ATG9B           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ATG9B



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ATG9B gene: 
NM_173681.5  

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000498521 ENST00000494791(uc003wig.4 uc011kvc.2) ENST00000486407
ENST00000404733 ENST00000476282 ENST00000471797 ENST00000464855 ENST00000469530
ENST00000473698 ENST00000473409 ENST00000473134 ENST00000466157 ENST00000377974
ENST00000444312 ENST00000605938 ENST00000605952
miRNA
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2 qRT-PCR Assays for microRNAs that regulate ATG9B:
hsa-miR-4316 hsa-miR-485-5p
SwitchGear 3'UTR luciferase reporter plasmidATG9B 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ATG9B
Predesigned siRNA for gene silencing in human, mouse, rat ATG9B
Clone
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG9B
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG9B
  QuantiTect SYBR Green Assays in human, mouse, rat ATG9B
  QuantiFast Probe-based Assays in human, mouse, rat ATG9B

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ATG9B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGGGTGGGT
ATG9B Expression
About this image

ATG9B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ATG9B Protein Expression

UniProtKB/Swiss-Prot: ATG9B_HUMAN, Q674R7
Tissue specificity: Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in
vascular endothelial

    Pathway & Disease-focused RT2 Profiler PCR Array including ATG9B: 
          Autophagy in human mouse rat

Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG9B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG9B gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Atg9b1 , 5 ATG9 autophagy related 9 homolog B (S. cerevisiae)5
autophagy related 9B1
85.58(n)1
87.18(a)1
  5 (11.49 cM)5
2139481  NM_001002897.31  NP_001002897.21 
 243841815 
lizard
(Anolis carolinensis)
Reptilia ATG9B6
autophagy related 9B
48(a)
1 ↔ 1
GL343807.1(1913-13984)
zebrafish
(Danio rerio)
Actinopterygii atg9b6
ATG9 autophagy related 9 homolog B (S. cerevisiae)...
46(a)
1 ↔ 1
24(35064904-35098243) ENSDARG00000055292
fruit fly
(Drosophila melanogaster)
Insecta Atg96
Autophagy-specific gene 9
32(a)
1 → many
2R(12181903-12184737)
worm
(Caenorhabditis elegans)
Secernentea atg-96
Protein ATG-9, isoform b (atg-9) mRNA, complete cd...
22(a)
1 → many
V(348789-358841) WBGene00020706
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG96
Transmembrane protein involved in forming Cvt and ...
15(a)
1 → many
IV(184925-187918) YDL149W


ENSEMBL Gene Tree for ATG9B (if available)
TreeFam Gene Tree for ATG9B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ATG9B gene
ATG9A2  
1 SIMAP similar gene for ATG9B using alignment to 4 protein entries:     ATG9B_HUMAN (see all proteins):
ATG9A

Find genes that share paralogs with ATG9B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ATG9B (see all 438)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs113936071,2
C--150043491(+) AAGGCC/-TCAGG 3 /A /GL fra12Minor allele frequency- -:0.00CSA 4
rs105435151,2
C--150718922(+) GTAGA-/GACAGGG 2 -- int10--------
rs113275681,2
C--150718949(+) CCAGA-/ATGGTT 2 -- int10--------
rs355786721,2
C--150719936(+) AAAAA-/A/AA  
        
GATAT
2 -- int11NA 2
rs1871102551,2
--154160948(+) TTCACC/TATGTT 2 -- ds50010--------
rs22563141,2
C,F,A,H--154160985(-) AGGATT/CGTGAG 2 -- ds500113Minor allele frequency- C:0.27NS NA WA CSA EA 560
rs39182351,2
C,F--154161058(+) tgAAGG/AATTTT 2 -- ds50018Minor allele frequency- A:0.02NS NA 418
rs1904369181,2
--154161118(+) GCCAGC/GAACCA 2 -- ds50010--------
rs1835083861,2
--154161207(+) AACTAC/TAAATA 2 -- ds50010--------
rs1884527421,2
--154161231(+) TACTGA/TACATA 2 -- ds50010--------

HapMap Linkage Disequilibrium report for ATG9B (150709297 - 150721586 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for ATG9B:    About this table    
Variant IDTypeSubtypePubMed ID
dgv1252e199CNV Deletion23128226
nsv889474CNV Loss21882294
nsv889473CNV Loss21882294
dgv7544n71CNV Loss21882294
nsv889465CNV Loss21882294
nsv526410CNV Loss19592680
nsv889471CNV Loss21882294
nsv889469CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing ATG9B
DNA2.0 Custom Variant and Variant Library Synthesis for ATG9B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612205    OMIM disorders: --

1 disease for ATG9B:    
About MalaCards
non-hodgkin lymphoma


Find genes that share disorders with ATG9B           About GenesLikeMe

Genetic Association Database (GAD): ATG9B
Human Genome Epidemiology (HuGE) Navigator: ATG9B (11 documents)

Export disorders for ATG9B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ATG9B gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with ATG9B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript. (PubMed id 15234981)1, 2, 3, 9 Robb G.B.... Marsden P.A. (J. Biol. Chem. 2004)
  2. Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast. (PubMed id 15755735)1, 2, 3 Yamada T.... Scherer S.W. (J. Biol. Chem. 2005)
  3. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
  5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
  6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  7. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
  8. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. (PubMed id 19197948)1, 4 Kang M.R....Lee S.H. (J. Pathol. 2009)
  9. Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma. (PubMed id 19423521)1, 4 Han X....Zhang Y. (amp 2009)
  10. Hypoxia-inducible expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase. (PubMed id 17403686)1, 2 Fish J.E.... Marsden P.A. (J. Biol. Chem. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 285973 HGNC: 21899 Ensembl:ENSG00000181652 euGenes: HUgn285973 ECgene: ATG9B
H-InvDB: ATG9B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ATG9B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ATG9B gene:
Search GeneIP for patents involving ATG9B

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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