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Aliases for ATG9B Gene

Aliases for ATG9B Gene

  • Autophagy Related 9B 2 3 5
  • Nitric Oxide Synthase 3-Overlapping Antisense Gene Protein 3 4
  • APG9-Like 2 3 4
  • NOS3AS 3 4
  • APG9L2 3 4
  • ATG9 Autophagy Related 9 Homolog B (S. Cerevisiae) 2
  • Endothelial Nitric Oxide Synthase Antisense 3
  • ATG9 Autophagy Related 9 Homolog B 3
  • Nitric Oxide Synthase 3 Antisense 2
  • Autophagy-Related Protein 9B 3
  • Autophagy 9-Like 2 Protein 3
  • Protein SONE 4
  • SONE 3

External Ids for ATG9B Gene

Previous HGNC Symbols for ATG9B Gene

  • NOS3AS

Previous GeneCards Identifiers for ATG9B Gene

  • GC07U901563
  • GC07M150170
  • GC07M150340
  • GC07M150710
  • GC07M144521

Summaries for ATG9B Gene

Entrez Gene Summary for ATG9B Gene

  • This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for ATG9B Gene

ATG9B (Autophagy Related 9B) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and Mitophagy - animal. An important paralog of this gene is ATG9A.

UniProtKB/Swiss-Prot for ATG9B Gene

  • Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG9B Gene

Genomics for ATG9B Gene

Regulatory Elements for ATG9B Gene

Enhancers for ATG9B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G151024 1.4 ENCODE dbSUPER 21 -2.4 -2390 5.6 CREB3L1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 GLIS1 NBN ATG9B ABCB8 ENSG00000244151 SLC4A2 LOC105375568
GH07G150959 2.1 VISTA Ensembl ENCODE dbSUPER 11.4 +61.7 61748 7.2 HDGF PKNOX1 CREB3L1 ARNT YBX1 ZNF766 ZNF143 KLF13 TAF15 REST AOC1 ATG9B ENSG00000243433 ABCB8 AGAP3 TMUB1 KCNH2 LOC105375567
GH07G151007 2 FANTOM5 Ensembl ENCODE dbSUPER 10 +13.4 13373 7.7 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 ARID4B DMAP1 SLC30A9 NOS3 KCNH2 ASIC3 CDK5 SLC4A2 FASTK ENSG00000244151 TMUB1 AGAP3 GBX1
GH07G150968 1.7 VISTA Ensembl ENCODE dbSUPER 11.1 +53.7 53673 4.7 HDAC1 HDGF PKNOX1 BMI1 ZNF766 CBX5 EGR1 ETV6 RELB IKZF2 AOC1 ATG9B ABCB8 ENSG00000243433 SLC4A2 TMUB1 AGAP3 ENSG00000244151 FASTK KCNH2
GH07G150973 1.6 Ensembl ENCODE dbSUPER 11.1 +49.9 49870 2.8 HDGF ARNT CREB3L1 SIN3A ZNF2 FOS KLF13 SP3 JUNB REST ATG9B ABCB8 ENSG00000243433 SLC4A2 AOC1 ENSG00000244151 FASTK TMUB1 AGAP3 KCNH2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATG9B on UCSC Golden Path with GeneCards custom track

Genomic Location for ATG9B Gene

Chromosome:
7
Start:
151,012,209 bp from pter
End:
151,024,499 bp from pter
Size:
12,291 bases
Orientation:
Minus strand

Genomic View for ATG9B Gene

Genes around ATG9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG9B Gene

Proteins for ATG9B Gene

  • Protein details for ATG9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q674R7-ATG9B_HUMAN
    Recommended name:
    Autophagy-related protein 9B
    Protein Accession:
    Q674R7
    Secondary Accessions:
    • A1A5D3
    • Q6JRW5
    • Q8N8I8

    Protein attributes for ATG9B Gene

    Size:
    924 amino acids
    Molecular mass:
    101019 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36. The genes are oriented in a tail-to-tail configuration and the mRNAs encoding ATG9B and NOS3 are complementary for 662 nucleotides. ATG9B transcription may a role in NOS3 transcription regulation.
    SequenceCaution:
    • Sequence=AAQ86941.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AC010973; Type=Frameshift; Positions=766; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG9B Gene

Post-translational modifications for ATG9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG9B Gene

No data available for DME Specific Peptides for ATG9B Gene

Domains & Families for ATG9B Gene

Gene Families for ATG9B Gene

Protein Domains for ATG9B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG9B Gene

Graphical View of Domain Structure for InterPro Entry

Q674R7

UniProtKB/Swiss-Prot:

ATG9B_HUMAN :
  • Belongs to the ATG9 family.
Family:
  • Belongs to the ATG9 family.
genes like me logo Genes that share domains with ATG9B: view

Function for ATG9B Gene

Molecular function for ATG9B Gene

UniProtKB/Swiss-Prot Function:
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle (By similarity).
UniProtKB/Swiss-Prot Induction:
By hypoxia, leading to inhibit NOS3 expression.
genes like me logo Genes that share phenotypes with ATG9B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATG9B Gene

Localization for ATG9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG9B Gene

Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1 and ATG13.

Gene Ontology (GO) - Cellular Components for ATG9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0000421 autophagosome membrane IEA --
GO:0005776 autophagosome IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ATG9B: view

No data available for Subcellular locations from COMPARTMENTS for ATG9B Gene

Pathways & Interactions for ATG9B Gene

genes like me logo Genes that share pathways with ATG9B: view

Pathways by source for ATG9B Gene

1 BioSystems pathway for ATG9B Gene
2 Reactome pathways for ATG9B Gene

Interacting Proteins for ATG9B Gene

Gene Ontology (GO) - Biological Process for ATG9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IDA 15755735
GO:0000422 mitophagy IBA --
GO:0006914 autophagy IEA --
GO:0034497 protein localization to pre-autophagosomal structure IBA --
GO:0034727 piecemeal microautophagy of nucleus IBA --
genes like me logo Genes that share ontologies with ATG9B: view

No data available for SIGNOR curated interactions for ATG9B Gene

Drugs & Compounds for ATG9B Gene

No Compound Related Data Available

Transcripts for ATG9B Gene

mRNA/cDNA for ATG9B Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATG9B Gene

Autophagy related 9B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG9B Gene

No ASD Table

Relevant External Links for ATG9B Gene

GeneLoc Exon Structure for
ATG9B
ECgene alternative splicing isoforms for
ATG9B

Expression for ATG9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG9B Gene

mRNA differential expression in normal tissues according to GTEx for ATG9B Gene

This gene is overexpressed in Esophagus - Mucosa (x12.5), Skin - Not Sun Exposed (Suprapubic) (x5.9), Skin - Sun Exposed (Lower leg) (x5.7), Pituitary (x5.2), Vagina (x4.9), Cervix - Ectocervix (x4.5), and Testis (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ATG9B Gene



NURSA nuclear receptor signaling pathways regulating expression of ATG9B Gene:

ATG9B

SOURCE GeneReport for Unigene cluster for ATG9B Gene:

Hs.707300

mRNA Expression by UniProt/SwissProt for ATG9B Gene:

Q674R7-ATG9B_HUMAN
Tissue specificity: Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.
genes like me logo Genes that share expression patterns with ATG9B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG9B Gene

Orthologs for ATG9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG9B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG9B 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia ATG9B 34
  • 87.18 (n)
cow
(Bos Taurus)
Mammalia ATG9B 34 35
  • 86.11 (n)
mouse
(Mus musculus)
Mammalia Atg9b 34 16 35
  • 85.58 (n)
rat
(Rattus norvegicus)
Mammalia Atg9b 34
  • 84.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ATG9B 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG9B 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii atg9b 35
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Atg9 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-9 35
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG9 35
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2027 35
  • 43 (a)
OneToMany
Species where no ortholog for ATG9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ATG9B Gene

ENSEMBL:
Gene Tree for ATG9B (if available)
TreeFam:
Gene Tree for ATG9B (if available)

Paralogs for ATG9B Gene

Paralogs for ATG9B Gene

(1) SIMAP similar genes for ATG9B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATG9B: view

Variants for ATG9B Gene

Sequence variations from dbSNP and Humsavar for ATG9B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000204701 -- 151,018,257(+) CCCAC(-/A)ACTTC intron-variant
rs1000281042 -- 151,016,961(+) TAAGG(C/T)GAGCC intron-variant
rs1000362669 -- 151,013,486(+) CCCAC(C/G)ACCAC intron-variant
rs1000880377 -- 151,012,987(+) GCCGC(A/G)CATTC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000885845 -- 151,021,498(+) TCACA(A/G)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG9B Gene

Variant ID Type Subtype PubMed ID
dgv1252e199 CNV deletion 23128226
dgv3695n106 OTHER inversion 24896259
esv3542654 CNV deletion 23714750
esv3615476 CNV loss 21293372
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv526410 CNV loss 19592680
nsv951648 CNV deletion 24416366

Variation tolerance for ATG9B Gene

Gene Damage Index Score: 9.28; 88.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG9B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG9B Gene

Disorders for ATG9B Gene

Relevant External Links for ATG9B

Genetic Association Database (GAD)
ATG9B
Human Genome Epidemiology (HuGE) Navigator
ATG9B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG9B

No disorders were found for ATG9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG9B Gene

Publications for ATG9B Gene

  1. Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript. (PMID: 15234981) Robb G.B. … Marsden P.A. (J. Biol. Chem. 2004) 2 3 4 22 64
  2. Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast. (PMID: 15755735) Yamada T. … Scherer S.W. (J. Biol. Chem. 2005) 2 3 4 64
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 46 64
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64

Products for ATG9B Gene

Sources for ATG9B Gene

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