Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ATG9A Gene

protein-coding   GIFtS: 54
GCID: GC02M220074

Autophagy Related 9A

(Previous names: APG9 autophagy 9-like 1 (S. cerevisiae), ATG9 autophagy...)
(Previous symbol: APG9L1)
  Search for ATG9A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Autophagy Related 9A1 2     MGD32082
APG9L11 2 3 5     APG9 Autophagy 9-Like 12
APG9-Like 12 3     ATG9 Autophagy Related 9 Homolog A2
mATG92 3     Autophagy 9-Like 1 Protein2
APG9 Autophagy 9-Like 1 (S. Cerevisiae)1     Autophagy-Related Protein 9A2
ATG9 Autophagy Related 9 Homolog A (S. Cerevisiae)1     

External Ids:    HGNC: 224081   Entrez Gene: 790652   Ensembl: ENSG000001989257   OMIM: 6122045   UniProtKB: Q7Z3C63   

Export aliases for ATG9A gene to outside databases

Previous GC identifers: GC02M219911 GC02M219792 GC02M211937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ATG9A Gene:
ATG9A (autophagy related 9A) is a protein-coding gene. An important paralog of this gene is ATG9B.

UniProtKB/Swiss-Prot: ATG9A_HUMAN, Q7Z3C6
Function: Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in
the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for
formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late
endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires
ULK1, ATG13 and SUPT20H

Gene Wiki entry for ATG9A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATG9A gene promoter:
         E2F   AP-1   MyoD   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG9A promoter sequence
   Search Chromatin IP Primers for ATG9A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATG9A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

ATG9A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG9A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M220074:  view genomic region     (about GC identifiers)

Start:
220,074,494 bp from pter      End:
220,094,439 bp from pter
Size:
19,946 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ATG9A_HUMAN, Q7Z3C6 (See protein sequence)
Recommended Name: Autophagy-related protein 9A  
Size: 839 amino acids; 94447 Da
Subunit: Interacts with SUPT20H
Sequence caution: Sequence=BAB13882.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15246.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB55119.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q3ZAQ6 Q6P0N7 Q7Z317 Q7Z320 Q8NDK6 Q8WU65 Q9BVL5 Q9H6L1 Q9HAG7
Alternative splicing: 3 isoforms:  Q7Z3C6-1   Q7Z3C6-2   Q7Z3C6-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ATG9A: NX_Q7Z3C6

Explore proteomics data for ATG9A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys225, Lys581
  • Glycosylation2 at Asn99
  • Modification sites at PhosphoSitePlus

  • See ATG9A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001070666.1  NP_076990.4  

    ENSEMBL proteins: 
     ENSP00000398528   ENSP00000386482   ENSP00000379983   ENSP00000386710   ENSP00000355173  
     ENSP00000386535   ENSP00000400234   ENSP00000396404   ENSP00000401530   ENSP00000404750  
     ENSP00000409164   ENSP00000393708   ENSP00000406785   ENSP00000413569   ENSP00000390704  
     ENSP00000398425   ENSP00000416435   ENSP00000394345  

    ATG9A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ATG9A
    OriGene Protein Over-expression Lysate for ATG9A
    OriGene MassSpec for ATG9A
    OriGene Custom Protein Services for ATG9A
    GenScript Custom Purified and Recombinant Proteins Services for ATG9A
    Novus Biologicals ATG9A Proteins
    Novus Biologicals ATG9A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATG9A

     
    Search eBioscience for Proteins for ATG9A 

    ATG9A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATG9A
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ATG9A 
    OriGene Antibodies for ATG9A
    OriGene Custom Antibody Services for ATG9A
    Novus Biologicals ATG9A Antibodies
    Abcam antibodies for ATG9A
    Cloud-Clone Corp. Antibodies for ATG9A
    ThermoFisher Antibodies for ATG9A
    LSBio Antibodies in human, mouse, rat for ATG9A

    ATG9A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATG9A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATG9A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATG9A
    Cloud-Clone Corp. CLIAs for ATG9A
    Search eBioscience for ELISAs for ATG9A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007241 Autophagy-rel_prot_9

    Graphical View of Domain Structure for InterPro Entry Q7Z3C6

    ProtoNet protein and cluster: Q7Z3C6

    UniProtKB/Swiss-Prot: ATG9A_HUMAN, Q7Z3C6
    Similarity: Belongs to the ATG9 family


    Find genes that share domains with ATG9A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATG9A_HUMAN, Q7Z3C6
    Function: Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in
    the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for
    formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late
    endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires
    ULK1, ATG13 and SUPT20H

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19893488
    GO:0015002heme-copper terminal oxidase activity ----
         
    Find genes that share ontologies with ATG9A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ATG9A:
     Increased gamma-H2AX phosphory  Large nuclei 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atg9a):
     cellular  immune system  mortality/aging 

    Find genes that share phenotypes with ATG9A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Atg9atm1Aki for ATG9A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATG9A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATG9A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATG9A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATG9A

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATG9A:
    hsa-mir-196a-5p (MIRT048263), hsa-mir-98-5p (MIRT027476), hsa-mir-103a-3p (MIRT027013), hsa-let-7b-5p (MIRT032232), hsa-mir-16-5p (MIRT001476)

    Block miRNA regulation of human, mouse, rat ATG9A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATG9A (see all 45):
    hsa-miR-21* hsa-let-7d hsa-miR-15a hsa-miR-29a hsa-miR-449a hsa-miR-3921 hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidATG9A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATG9A
    Predesigned siRNA for gene silencing in human, mouse, rat ATG9A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATG9A

    Clone
    Products:
         
    OriGene clones in human, mouse for ATG9A (see all 13)
    OriGene ORF clones in mouse, rat for ATG9A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATG9A (NM_001077198)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG9A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG9A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATG9A
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATG9A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG9A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ATG9A_HUMAN, Q7Z3C6: Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus,
    trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin
    treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The
    starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    vacuole5
    golgi apparatus3
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000421autophagic vacuole membrane IEA--
    GO:0005737cytoplasm ----
    GO:0005768endosome IDA--
    GO:0005770late endosome ----
    GO:0005776autophagic vacuole ----

    Find genes that share ontologies with ATG9A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including ATG9A: 
              Autophagy in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATG9A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATG9A (Q7Z3C61, 2, 3 ENSP000003551734) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 3, ENSP000003299674EBI-727146,EBI-356402 I2D: score=1 STRING: ENSP00000329967
    TGOLN2O434932, 3, ENSP000003666034MINT-8142052 I2D: score=1 STRING: ENSP00000366603
    MAPK6Q166592, 3MINT-8260735 I2D: score=2 
    SUPT20HQ8NEM72, ENSP000002188944MINT-7557407 MINT-7557250 MINT-7557367 MINT-7557337 MINT-7557381 MINT-7557272 MINT-7557312 MINT-7557352 STRING: ENSP00000218894
    ENSG00000096150P622693I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IMP15755735
    GO:0006914autophagy ----
    GO:0015031protein transport IEA--
    GO:0034067protein localization to Golgi apparatus IEA--
    GO:0045087innate immune response IEA--

    Find genes that share ontologies with ATG9A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATG9A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ATG9A gene (2 alternative transcripts): 
    NM_001077198.2  NM_024085.4  

    Unigene Cluster for ATG9A:

    Autophagy related 9A
    Hs.323363  [show with all ESTs]
    Unigene Representative Sequence: BX537984
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000446716(uc002vkc.2 uc010fwe.2 uc010zku.1) ENST00000409033(uc002vkd.1)
    ENST00000396761(uc002vke.1 uc002vkf.1) ENST00000409618 ENST00000361242
    ENST00000475339 ENST00000409422 ENST00000429920 ENST00000431715 ENST00000436856
    ENST00000457841 ENST00000428226 ENST00000412355 ENST00000432520 ENST00000439812
    ENST00000456708 ENST00000466217 ENST00000486766
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATG9A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATG9A (see all 45):
    hsa-miR-21* hsa-let-7d hsa-miR-15a hsa-miR-29a hsa-miR-449a hsa-miR-3921 hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidATG9A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATG9A
    Predesigned siRNA for gene silencing in human, mouse, rat ATG9A
    Clone
    Products:
         
    OriGene clones in human, mouse for ATG9A (see all 13)
    OriGene ORF clones in mouse, rat for ATG9A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATG9A (NM_001077198)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG9A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG9A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ATG9A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG9A
      QuantiTect SYBR Green Assays in human, mouse, rat ATG9A
      QuantiFast Probe-based Assays in human, mouse, rat ATG9A

    Additional mRNA sequence: 

    AK021732.1 AK025822.1 AK027448.1 AK056595.1 AK289755.1 AK302521.1 AK315553.1 AL833865.1 
    BC001098.2 BC001206.1 BC021202.2 BX537984.1 BX538192.1 BX538198.1 

    23 DOTS entries:

    DT.114586  DT.40106917  DT.100713879  DT.100869508  DT.100650765  DT.95110029  DT.92072228  DT.95258709 
    DT.100859437  DT.95257977  DT.95258693  DT.121017571  DT.92072274  DT.100650770  DT.100767825  DT.121017532 
    DT.121017581  DT.121017672  DT.85104287  DT.95127240  DT.95258691  DT.91927823  DT.95258694 

    Selected AceView cDNA sequences (see all 299):

    AL701566 BX110282 BU521407 AU118953 AI863325 BQ681220 BM915365 BP346414 
    BC065534 BX355626 CR617520 AI698963 CD631903 BM915540 BM701420 BQ049564 
    BF981293 AA459390 BI561139 BM912762 BP364257 CA389678 BG769952 BQ652149 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATG9A (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^
    SP1:                    -     -                                                                                                                       -         
    SP2:                    -     -                                                                                   -     -                             -         
    SP3:                    -     -     -                                                                                                                 -         
    SP4:                    -                                                                                                                                       
    SP5:                    -     -                                                                                                                                 

    ExUns: 16 ^ 17 ^ 18a · 18b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ATG9A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ATG9A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGACTGC
    ATG9A Expression
    About this image

    ATG9A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATG9A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.323363
        Pathway & Disease-focused RT2 Profiler PCR Array including ATG9A: 
              Autophagy in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ATG9A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG9A
    QuantiTect SYBR Green Assays in human, mouse, rat ATG9A
    QuantiFast Probe-based Assays in human, mouse, rat ATG9A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG9A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ATG9A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg9a1 , 5 autophagy-related 9A (yeast)5
    autophagy related 9A1
    91.3(n)1
    97.97(a)1
      1 (38.62 cM)5
    2458601  NM_001003917.31  NP_001003917.21 
     751808665 
    chicken
    (Gallus gallus)
    Aves ATG9A1 autophagy related 9A 76.95(n)
    83.37(a)
      425722  NM_001034821.1  NP_001029993.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATG9A6
    autophagy related 9A
    82(a)
    1 ↔ 1
    1(95789442-95807640)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atg9a1 autophagy related 9A 69.59(n)
    72.72(a)
      100497686  XM_002933948.2  XP_002933994.2 
    zebrafish
    (Danio rerio)
    Actinopterygii atg9a1 ATG9 autophagy related 9 homolog A (S. cerevisiae) 70.51(n)
    76.07(a)
      100009663  NM_001083031.1  NP_001076500.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atg96
    Autophagy-specific gene 9
    38(a)
    1 → many
    2R(12181903-12184737)
    worm
    (Caenorhabditis elegans)
    Secernentea atg-96
    Protein ATG-9, isoform b (atg-9) mRNA, complete cd...
    27(a)
    1 → many
    V(348789-358841) WBGene00020706
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG9(YDL149W)4 Transmembrane protein involved in forming Cvt and autophagic more   --   4(184925-187918) 851406  NP_010132.1 


    ENSEMBL Gene Tree for ATG9A (if available)
    TreeFam Gene Tree for ATG9A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ATG9A gene
    ATG9B2  
    1 SIMAP similar gene for ATG9A using alignment to 12 protein entries:     ATG9A_HUMAN (see all proteins):
    ATG9B

    Find genes that share paralogs with ATG9A           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ATG9A
    PGOHUM00000262012 PGOHUM00000262013


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ATG9A (see all 221)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22766331,2
    C,F,A,H--220085845(+) AGGGCG/AGTGGT 4 /T syn1 ese322Minor allele frequency- A:0.09EA NA NS WA CSA EU 2832
    rs1151939021,2
    C,F--220085847(+) GGCAGT/CGGTCT 4 /T /A mis11Minor allele frequency- C:0.03WA 118
    rs2008582821,2
    C--220085922(+) CCGGGC/GGCCCT 4 P A mis10--------
    rs2018430791,2
    C--220085975(+) CCCGGC/TGGTGC 4 H R mis10--------
    rs1438141141,2
    C--220086043(+) GGGCTC/TGTTAG 2 -- int10--------
    rs1878830721,2
    --220086178(+) TACCTC/TTGATC 2 -- int10--------
    rs99898541,2
    C,F,A,H--220086280(+) ACTGAT/CGGTCT 2 -- int128Minor allele frequency- C:0.29NS EA NA CSA WA 2780
    rs1923602851,2
    --220086350(+) CCAGCC/GCTTGT 2 -- int10--------
    rs1472810381,2
    --220086403(+) AATAAA/GGAAAA 2 -- int10--------
    rs1397653151,2
    C--220086417(+) ATGATA/GTGTCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ATG9A (220074494 - 220094439 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ATG9A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834543CNV Loss17160897
    nsv875869CNV Loss21882294
    nsv875870CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATG9A
    DNA2.0 Custom Variant and Variant Library Synthesis for ATG9A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612204    OMIM disorders: --


    Find genes that share disorders with ATG9A           About GenesLikeMe

    Genetic Association Database (GAD): ATG9A
    Human Genome Epidemiology (HuGE) Navigator: ATG9A (2 documents)

    Export disorders for ATG9A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ATG9A gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with ATG9A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy. (PubMed id 21068542)1, 2 Takahashi Y.... Wang H.G. (Autophagy 2011)
    2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP. (PubMed id 19893488)1, 2 Webber J.L. and Tooze S.A. (EMBO J. 2010)
    5. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. (PubMed id 16940348)1, 2 Young A.R.... Tooze S.A. (J. Cell Sci. 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast. (PubMed id 15755735)1, 2 Yamada T.... Scherer S.W. (J. Biol. Chem. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. ATG9A overexpression is associated with disease recurrence and poor survival in patients with oral squamous cell carcinoma. (PubMed id 24085552)1 Tang J.Y....Chai C.Y. (Virchows Arch. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79065 HGNC: 22408 AceView: FLJ22169 Ensembl:ENSG00000198925 euGenes: HUgn79065
    ECgene: ATG9A H-InvDB: ATG9A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ATG9A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ATG9A gene:
    Search GeneIP for patents involving ATG9A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ATG9A
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ATG9A   OriGene RNAi products in human, mouse, rat for ATG9A  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ATG9A  
     OriGene MassSpec something-or-other for ATG9A   OriGene clones in human, mouse for ATG9A  
     OriGene qSTAR qPCR primer pairs in human, mouse for ATG9A   OriGene Purified Protein for ATG9A  
     OriGene ORF clones in mouse, rat for ATG9A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATG9A   OriGene Custom Protein Services for ATG9A  

     
     
     Block miRNA regulation of human, mouse, rat ATG9A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ATG9A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATG9A Predesigned siRNA for gene silencing in human, mouse, rat ATG9A
     QuantiFast Probe-based Assays in human, mouse, rat ATG9A QuantiTect SYBR Green Assays in human, mouse, rat ATG9A
     PCR Arrays including human, mouse, rat ATG9A Search Chromatin IP Primers for ATG9A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG9A  Search GeneGlobe Interaction Network for ATG9A
     Regulatory tfbs in ATG9A promoter
     GenScript Custom Purified and Recombinant Proteins Services for ATG9A GenScript cDNA clones with any tag delivered in your preferred vector for ATG9A
     GenScript Custom Assay Services for ATG9A GenScript Custom overexpressing Cell Line Services for ATG9A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ATG9A 

     Search Tocris compounds for ATG9A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ATG9A antibodies
     ATG9A proteins
     ATG9A lysates
     Antibodies for ATG9A
     See all of Abcam's Antibodies, Kits and Proteins for ATG9A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ATG9A
     Antibodies for ATG9A
     ELISAs for ATG9A
     CLIAs for ATG9A



     Browse ESI BIO Cell Lines and PureStem Progenitors for ATG9A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG9A
     SwitchGear 3'UTR luciferase reporter plasmids for ATG9A
     SwitchGear Promoter luciferase reporter plasmids for ATG9A
     ThermoFisher Antibodies for ATG9A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG9A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATG9A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATG9A
     LSBio Antibodies in human, mouse, rat for ATG9A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ATG9A
      Search eBioscience for proteins for ATG9A
      Search eBioscience for elisas for ATG9A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ATG9A gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4