Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATG9A Gene

Aliases for ATG9A Gene

  • Autophagy Related 9A 2 3 5
  • APG9-Like 1 3 4
  • APG9L1 3 4
  • MATG9 3 4
  • ATG9 Autophagy Related 9 Homolog A (S. Cerevisiae) 2
  • APG9 Autophagy 9-Like 1 (S. Cerevisiae) 2
  • ATG9 Autophagy Related 9 Homolog A 3
  • Autophagy-Related Protein 9A 3
  • Autophagy 9-Like 1 Protein 3
  • APG9 Autophagy 9-Like 1 3
  • MGD3208 3

External Ids for ATG9A Gene

Previous HGNC Symbols for ATG9A Gene

  • APG9L1

Previous GeneCards Identifiers for ATG9A Gene

  • GC02M219911
  • GC02M219792
  • GC02M220074
  • GC02M211937

Summaries for ATG9A Gene

GeneCards Summary for ATG9A Gene

ATG9A (Autophagy Related 9A) is a Protein Coding gene. Among its related pathways are Cellular Senescence and mTOR signalling. GO annotations related to this gene include heme-copper terminal oxidase activity. An important paralog of this gene is ATG9B.

UniProtKB/Swiss-Prot for ATG9A Gene

  • Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.

Gene Wiki entry for ATG9A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG9A Gene

Genomics for ATG9A Gene

Regulatory Elements for ATG9A Gene

Enhancers for ATG9A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F219244 1.1 ENCODE 12.6 -20.4 -20401 11.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YBX1 GLB1L LINC00608 LINC01803 ZFAND2B ANKZF1 ATG9A TUBA4A DNAJB2 MIR153-1 PTPRN
GH02F219683 1.2 Ensembl ENCODE 4.3 -458.0 -457959 7.4 PKNOX1 ATF1 ARID4B ZNF143 ZNF263 SP3 GTF2B NFYC REST ZNF592 OBSL1 CHPF TMEM198 SLC4A3 ENSG00000228973 DNPEP DNAJB2 ATG9A LOC105373886 RPL23P4
GH02F218838 0.9 FANTOM5 Ensembl ENCODE 5.4 +390.2 390169 1.2 CEBPB SLC11A1 LOC100129175 MIR375 ATG9A USP37 TTLL4 CYP27A1 RPL23AP31 PRKAG3
GH02F220043 0.6 ENCODE 4.4 -814.5 -814545 1.4 JUND SMARCA4 POLR2A FOS ZNF7 ATG9A ENSG00000225911 GC02P219984
GH02F219272 1.4 FANTOM5 Ensembl ENCODE 1.8 -44.4 -44380 3.6 TBP SIN3A RAD21 GLIS2 ZNF366 FOS CEBPB SMARCB1 ZNF341 GLIS1 GLB1L PTPRN CFAP65 TUBA4B INHA ATG9A TUBA4A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATG9A on UCSC Golden Path with GeneCards custom track

Promoters for ATG9A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000607781 17 2201 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ATG9A Gene

Chromosome:
2
Start:
219,209,772 bp from pter
End:
219,229,717 bp from pter
Size:
19,946 bases
Orientation:
Minus strand

Genomic View for ATG9A Gene

Genes around ATG9A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG9A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG9A Gene

Proteins for ATG9A Gene

  • Protein details for ATG9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3C6-ATG9A_HUMAN
    Recommended name:
    Autophagy-related protein 9A
    Protein Accession:
    Q7Z3C6
    Secondary Accessions:
    • Q3ZAQ6
    • Q6P0N7
    • Q7Z317
    • Q7Z320
    • Q8NDK6
    • Q8WU65
    • Q9BVL5
    • Q9H6L1
    • Q9HAG7

    Protein attributes for ATG9A Gene

    Size:
    839 amino acids
    Molecular mass:
    94447 Da
    Quaternary structure:
    • Interacts with SUPT20H.
    SequenceCaution:
    • Sequence=BAB13882.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15246.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55119.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG9A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG9A Gene

Post-translational modifications for ATG9A Gene

  • Ubiquitination at Lys 225 and Lys 581
  • Glycosylation at Asn 99
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ATG9A Gene

Domains & Families for ATG9A Gene

Gene Families for ATG9A Gene

Protein Domains for ATG9A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG9A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3C6

UniProtKB/Swiss-Prot:

ATG9A_HUMAN :
  • Belongs to the ATG9 family.
Family:
  • Belongs to the ATG9 family.
genes like me logo Genes that share domains with ATG9A: view

Function for ATG9A Gene

Molecular function for ATG9A Gene

UniProtKB/Swiss-Prot Function:
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.

Gene Ontology (GO) - Molecular Function for ATG9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19893488
genes like me logo Genes that share ontologies with ATG9A: view
genes like me logo Genes that share phenotypes with ATG9A: view

Animal Models for ATG9A Gene

MGI Knock Outs for ATG9A:

Animal Model Products

miRNA for ATG9A Gene

miRTarBase miRNAs that target ATG9A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATG9A Gene

Localization for ATG9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG9A Gene

Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG9A gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
endosome 5
plasma membrane 3
lysosome 2

Gene Ontology (GO) - Cellular Components for ATG9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IDA 22456507
GO:0000421 NOT autophagosome membrane IDA 22456507
GO:0005768 endosome IDA 23093945
GO:0005770 late endosome IDA 22456507
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with ATG9A: view

Pathways & Interactions for ATG9A Gene

genes like me logo Genes that share pathways with ATG9A: view

Pathways by source for ATG9A Gene

2 Reactome pathways for ATG9A Gene
1 R&D Systems pathway for ATG9A Gene

Gene Ontology (GO) - Biological Process for ATG9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IMP 15755735
GO:0000422 mitophagy IBA --
GO:0006810 transport IEA --
GO:0006914 autophagy IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with ATG9A: view

No data available for SIGNOR curated interactions for ATG9A Gene

Transcripts for ATG9A Gene

Unigene Clusters for ATG9A Gene

Autophagy related 9A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG9A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - -
SP7: - -
SP8:
SP9: -
SP10:
SP11: - - - -
SP12:
SP13:

ExUns: 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ATG9A Gene

GeneLoc Exon Structure for
ATG9A
ECgene alternative splicing isoforms for
ATG9A

Expression for ATG9A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATG9A Gene

mRNA differential expression in normal tissues according to GTEx for ATG9A Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for ATG9A Gene

This gene is overexpressed in Breast (11.7), Pancreas (10.7), Cervix (9.7), Testis (8.7), Bone (7.3), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATG9A Gene



Protein tissue co-expression partners for ATG9A Gene

NURSA nuclear receptor signaling pathways regulating expression of ATG9A Gene:

ATG9A

SOURCE GeneReport for Unigene cluster for ATG9A Gene:

Hs.323363
genes like me logo Genes that share expression patterns with ATG9A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATG9A Gene

Orthologs for ATG9A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG9A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG9A 34 35
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia ATG9A 34 35
  • 93.21 (n)
dog
(Canis familiaris)
Mammalia ATG9A 34 35
  • 92.85 (n)
mouse
(Mus musculus)
Mammalia Atg9a 34 16 35
  • 91.3 (n)
rat
(Rattus norvegicus)
Mammalia Atg9a 34
  • 91.22 (n)
oppossum
(Monodelphis domestica)
Mammalia ATG9A 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG9A 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG9A 34 35
  • 76.95 (n)
lizard
(Anolis carolinensis)
Reptilia ATG9A 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg9a 34
  • 69.59 (n)
zebrafish
(Danio rerio)
Actinopterygii atg9a 34 35
  • 70.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta Atg9 35
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-9 35
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG9 35 37
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2027 35
  • 56 (a)
OneToMany
Species where no ortholog for ATG9A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG9A Gene

ENSEMBL:
Gene Tree for ATG9A (if available)
TreeFam:
Gene Tree for ATG9A (if available)

Paralogs for ATG9A Gene

Paralogs for ATG9A Gene

genes like me logo Genes that share paralogs with ATG9A: view

Variants for ATG9A Gene

Sequence variations from dbSNP and Humsavar for ATG9A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10799 -- 219,220,216(-) CCCAG(A/G)ACCCC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs111273403 -- 219,219,080(+) CGAAT(A/G)CAAAT intron-variant, upstream-variant-2KB
rs112283816 -- 219,226,413(+) GGCGT(A/G)GTGGC intron-variant
rs112388239 -- 219,231,080(+) TGCAC(C/T)TCTCC intron-variant, upstream-variant-2KB
rs113304445 -- 219,226,180(+) ATCTC(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG9A Gene

Variant ID Type Subtype PubMed ID
esv3893555 CNV loss 25118596
nsv584500 CNV loss 21841781
nsv834543 CNV loss 17160897

Variation tolerance for ATG9A Gene

Residual Variation Intolerance Score: 6.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG9A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG9A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG9A Gene

Disorders for ATG9A Gene

Relevant External Links for ATG9A

Genetic Association Database (GAD)
ATG9A
Human Genome Epidemiology (HuGE) Navigator
ATG9A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG9A

No disorders were found for ATG9A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG9A Gene

Publications for ATG9A Gene

  1. Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy. (PMID: 21068542) Takahashi Y. … Wang H.G. (Autophagy 2011) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 64
  4. Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP. (PMID: 19893488) Webber J.L. … Tooze S.A. (EMBO J. 2010) 3 4 64
  5. Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. (PMID: 16940348) Young A.R. … Tooze S.A. (J. Cell Sci. 2006) 3 4 64

Products for ATG9A Gene

Sources for ATG9A Gene

Content
Loading form....