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Aliases for ATG9A Gene

Aliases for ATG9A Gene

  • Autophagy Related 9A 2 3
  • APG9L1 3 4 6
  • APG9-Like 1 3 4
  • MATG9 3 4
  • ATG9 Autophagy Related 9 Homolog A (S. Cerevisiae) 2
  • APG9 Autophagy 9-Like 1 (S. Cerevisiae) 2
  • ATG9 Autophagy Related 9 Homolog A 3
  • Autophagy-Related Protein 9A 3
  • Autophagy 9-Like 1 Protein 3
  • APG9 Autophagy 9-Like 1 3
  • MGD3208 3

External Ids for ATG9A Gene

Previous HGNC Symbols for ATG9A Gene

  • APG9L1

Previous GeneCards Identifiers for ATG9A Gene

  • GC02M219911
  • GC02M219792
  • GC02M220074
  • GC02M211937

Summaries for ATG9A Gene

GeneCards Summary for ATG9A Gene

ATG9A (Autophagy Related 9A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ATG9A Gene

  • Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.

Gene Wiki entry for ATG9A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG9A Gene

Genomics for ATG9A Gene

Regulatory Elements for ATG9A Gene

Genomic Location for ATG9A Gene

Start:
219,209,772 bp from pter
End:
219,229,717 bp from pter
Size:
19,946 bases
Orientation:
Minus strand

Genomic View for ATG9A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG9A Gene

Proteins for ATG9A Gene

  • Protein details for ATG9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3C6-ATG9A_HUMAN
    Recommended name:
    Autophagy-related protein 9A
    Protein Accession:
    Q7Z3C6
    Secondary Accessions:
    • Q3ZAQ6
    • Q6P0N7
    • Q7Z317
    • Q7Z320
    • Q8NDK6
    • Q8WU65
    • Q9BVL5
    • Q9H6L1
    • Q9HAG7

    Protein attributes for ATG9A Gene

    Size:
    839 amino acids
    Molecular mass:
    94447 Da
    Quaternary structure:
    • Interacts with SUPT20H.
    SequenceCaution:
    • Sequence=BAB13882.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15246.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55119.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG9A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG9A Gene

Proteomics data for ATG9A Gene at MOPED

Post-translational modifications for ATG9A Gene

  • Ubiquitination at Lys225 and Lys581
  • Glycosylation at Asn99
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ATG9A (ATG9A)
  • Santa Cruz Biotechnology (SCBT) Antibodies for ATG9A

No data available for DME Specific Peptides for ATG9A Gene

Domains for ATG9A Gene

Protein Domains for ATG9A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG9A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3C6

UniProtKB/Swiss-Prot:

ATG9A_HUMAN :
  • Q7Z3C6
Family:
  • Belongs to the ATG9 family.
genes like me logo Genes that share domains with ATG9A: view

No data available for Gene Families for ATG9A Gene

Function for ATG9A Gene

Molecular function for ATG9A Gene

UniProtKB/Swiss-Prot Function:
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.

Gene Ontology (GO) - Molecular Function for ATG9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19893488
GO:0015002 heme-copper terminal oxidase activity --
genes like me logo Genes that share ontologies with ATG9A: view

Phenotypes for ATG9A Gene

genes like me logo Genes that share phenotypes with ATG9A: view

Animal Models for ATG9A Gene

MGI Knock Outs for ATG9A:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG9A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ATG9A Gene

Localization for ATG9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG9A Gene

Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG9A Gene COMPARTMENTS Subcellular localization image for ATG9A gene
Compartment Confidence
endosome 5
vacuole 5
golgi apparatus 3
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ATG9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IDA 22456507
GO:0000421 NOT autophagic vacuole membrane IDA 22456507
GO:0005737 cytoplasm --
GO:0005768 endosome IDA 23093945
GO:0005770 late endosome IDA 22456507
genes like me logo Genes that share ontologies with ATG9A: view

Pathways for ATG9A Gene

SuperPathways for ATG9A Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ATG9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IMP 15755735
GO:0000422 mitochondrion degradation IBA --
GO:0006914 autophagy --
GO:0015031 protein transport IEA --
GO:0034067 protein localization to Golgi apparatus IEA --
genes like me logo Genes that share ontologies with ATG9A: view

No data available for Pathways by source for ATG9A Gene

Transcripts for ATG9A Gene

Unigene Clusters for ATG9A Gene

Autophagy related 9A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG9A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG9A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - -
SP7: - -
SP8:
SP9: -
SP10:
SP11: - - - -
SP12:
SP13:

ExUns: 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ATG9A Gene

GeneLoc Exon Structure for
ATG9A
ECgene alternative splicing isoforms for
ATG9A

Expression for ATG9A Gene

mRNA expression in normal human tissues for ATG9A Gene

mRNA differential expression in normal tissues according to GTEx for ATG9A Gene

This gene is overexpressed in Muscle - Skeletal (4.5).

Protein differential expression in normal tissues for ATG9A Gene

This gene is overexpressed in Breast (11.7), Pancreas (10.7), Cervix (9.7), Testis (8.7), Bone (7.3), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATG9A Gene

SOURCE GeneReport for Unigene cluster for ATG9A Gene Hs.323363

genes like me logo Genes that share expressions with ATG9A: view

Expression partners for ATG9A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATG9A Gene

Orthologs for ATG9A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG9A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATG9A 35
  • 93.21 (n)
  • 98.57 (a)
ATG9A 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG9A 35
  • 92.85 (n)
  • 98.33 (a)
ATG9A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg9a 35
  • 91.3 (n)
  • 97.97 (a)
Atg9a 16
Atg9a 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATG9A 35
  • 99.68 (n)
  • 99.76 (a)
ATG9A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg9a 35
  • 91.22 (n)
  • 98.33 (a)
oppossum
(Monodelphis domestica)
Mammalia ATG9A 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG9A 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG9A 35
  • 76.95 (n)
  • 83.37 (a)
ATG9A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG9A 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg9a 35
  • 69.59 (n)
  • 72.72 (a)
zebrafish
(Danio rerio)
Actinopterygii atg9a 35
  • 70.51 (n)
  • 76.07 (a)
atg9a 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Atg9 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-9 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG9 36
  • 16 (a)
OneToMany
ATG9 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2027 36
  • 56 (a)
OneToMany
Species with no ortholog for ATG9A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG9A Gene

ENSEMBL:
Gene Tree for ATG9A (if available)
TreeFam:
Gene Tree for ATG9A (if available)

Paralogs for ATG9A Gene

Pseudogenes.org Pseudogenes for ATG9A Gene

genes like me logo Genes that share paralogs with ATG9A: view

No data available for Paralogs for ATG9A Gene

Variants for ATG9A Gene

Sequence variations from dbSNP and Humsavar for ATG9A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs908196 -- 219,223,526(+) TTCCC(A/G)AAGAC intron-variant
rs2276633 -- 219,221,123(+) AGGGC(A/G)GTGGT synonymous-codon, reference, nc-transcript-variant
rs2276634 - 219,222,322(+) CCGGG(A/T)TGCAG reference, missense, nc-transcript-variant
rs2276635 - 219,222,719(+) GAGGC(C/T)AGCAG reference, missense, nc-transcript-variant
rs2276636 -- 219,223,786(+) AAGGT(A/C)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG9A Gene

Variant ID Type Subtype PubMed ID
nsv875869 CNV Loss 21882294
nsv875870 CNV Gain+Loss 21882294
nsv834543 CNV Loss 17160897

Relevant External Links for ATG9A Gene

HapMap Linkage Disequilibrium report
ATG9A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG9A Gene

Disorders for ATG9A Gene

Relevant External Links for ATG9A

Genetic Association Database (GAD)
ATG9A
Human Genome Epidemiology (HuGE) Navigator
ATG9A

No disorders were found for ATG9A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ATG9A Gene

Publications for ATG9A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 48
  3. Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy. (PMID: 21068542) Takahashi Y. … Wang H.G. (Autophagy 2011) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ATG9A Gene

Sources for ATG9A Gene

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