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Aliases for ATG7 Gene

Aliases for ATG7 Gene

  • Autophagy Related 7 2 3 5
  • Ubiquitin-Activating Enzyme E1-Like Protein 2 3 4
  • ATG12-Activating Enzyme E1 ATG7 3 4
  • APG7-LIKE 3 4
  • APG7L 3 4
  • HAGP7 3 4
  • ATG7 Autophagy Related 7 Homolog (S. Cerevisiae) 2
  • Ubiquitin-Like Modifier-Activating Enzyme ATG7 3
  • APG7 Autophagy 7-Like (S. Cerevisiae) 2
  • Autophagy-Related Protein 7 4
  • APG7 Autophagy 7-Like 3
  • GSA7 3

External Ids for ATG7 Gene

Previous HGNC Symbols for ATG7 Gene

  • APG7L

Previous GeneCards Identifiers for ATG7 Gene

  • GC03P011290

Summaries for ATG7 Gene

Entrez Gene Summary for ATG7 Gene

  • This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for ATG7 Gene

ATG7 (Autophagy Related 7) is a Protein Coding gene. Among its related pathways are Immune System and HIV Life Cycle. GO annotations related to this gene include protein homodimerization activity and ubiquitin activating enzyme activity.

UniProtKB/Swiss-Prot for ATG7 Gene

  • E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

Gene Wiki entry for ATG7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG7 Gene

Genomics for ATG7 Gene

Regulatory Elements for ATG7 Gene

Enhancers for ATG7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F011271 1.5 FANTOM5 ENCODE 39 +1.1 1060 3.3 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ATG7 HRH1 VGLL4 ENSG00000226621
GH03F011250 0.2 ENCODE 29.9 -21.2 -21176 0.9 ARID1B RNF2 MTA2 TAL1 IKZF1 GABPA ATG7 PIR61529 CHCHD4P4
GH03F011281 0.8 FANTOM5 Ensembl ENCODE 27.8 +10.6 10589 2.0 ZIC2 ATG7 HRH1 ENSG00000226621
GH03F011295 0.3 FANTOM5 25.8 +23.3 23263 0.2 ATG7 HRH1 ENSG00000226621 PIR49308
GH03F011286 1.6 FANTOM5 Ensembl ENCODE 24.8 +17.3 17292 6.0 PKNOX1 ATF1 ELK1 FOS JUNB NCOA1 REST TBX21 MAFF SMARCA4 ATG7 HRH1 ENSG00000271716 ENSG00000226621
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ATG7 on UCSC Golden Path with GeneCards custom track

Promoters for ATG7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001357349 691 2401 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for ATG7 Gene

Chromosome:
3
Start:
11,272,309 bp from pter
End:
11,557,665 bp from pter
Size:
285,357 bases
Orientation:
Plus strand

Genomic View for ATG7 Gene

Genes around ATG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG7 Gene

Proteins for ATG7 Gene

  • Protein details for ATG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95352-ATG7_HUMAN
    Recommended name:
    Ubiquitin-like modifier-activating enzyme ATG7
    Protein Accession:
    O95352
    Secondary Accessions:
    • B4E170
    • E9PB95
    • Q7L8L0
    • Q9BWP2
    • Q9UFH4

    Protein attributes for ATG7 Gene

    Size:
    703 amino acids
    Molecular mass:
    77960 Da
    Quaternary structure:
    • Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Forms intermediate conjugates with ATG8-like proteins such as GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A. Interacts with EP300 acetyltransferase. Interacts with FOXO1.

    Alternative splice isoforms for ATG7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG7 Gene

Post-translational modifications for ATG7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ATG7 (ATG7)
  • Santa Cruz Biotechnology (SCBT) Antibodies for ATG7

No data available for DME Specific Peptides for ATG7 Gene

Domains & Families for ATG7 Gene

Protein Domains for ATG7 Gene

Suggested Antigen Peptide Sequences for ATG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95352

UniProtKB/Swiss-Prot:

ATG7_HUMAN :
  • The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.
  • Belongs to the ATG7 family.
Domain:
  • The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.
  • The N-terminal FAP motif (residues 15 to 17) is essential for the formation of the ATG89-PE and ATG5-ATG12 conjugates.
Family:
  • Belongs to the ATG7 family.
genes like me logo Genes that share domains with ATG7: view

Function for ATG7 Gene

Molecular function for ATG7 Gene

UniProtKB/Swiss-Prot Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
UniProtKB/Swiss-Prot Induction:
Expression is up-regulated by the transcription factor HSF1.

Gene Ontology (GO) - Molecular Function for ATG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004839 ubiquitin activating enzyme activity TAS 10233149
GO:0005515 protein binding IPI 11096062
GO:0008134 transcription factor binding IPI 20543840
GO:0008641 small protein activating enzyme activity IEA --
GO:0019778 Atg12 activating enzyme activity ISS,IBA 20723759
genes like me logo Genes that share ontologies with ATG7: view
genes like me logo Genes that share phenotypes with ATG7: view

Animal Models for ATG7 Gene

MGI Knock Outs for ATG7:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATG7 Gene

Localization for ATG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG7 Gene

Cytoplasm. Preautophagosomal structure. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG7 Gene COMPARTMENTS Subcellular localization image for ATG7 gene
Compartment Confidence
cytosol 5
lysosome 3
mitochondrion 3
nucleus 3
vacuole 3
endoplasmic reticulum 2
cytoskeleton 1
endosome 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ATG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005737 cytoplasm IEA,IDA 20543840
GO:0005829 cytosol IBA,TAS --
GO:0005930 axoneme ISS --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with ATG7: view

Pathways & Interactions for ATG7 Gene

genes like me logo Genes that share pathways with ATG7: view

Pathways by source for ATG7 Gene

1 KEGG pathway for ATG7 Gene
2 R&D Systems pathways for ATG7 Gene

SIGNOR curated interactions for ATG7 Gene

Gene Ontology (GO) - Biological Process for ATG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10233149
GO:0006497 protein lipidation IDA 12890687
GO:0006501 C-terminal protein lipidation IBA --
GO:0006810 transport IEA --
GO:0006914 autophagy IEA,IMP 25327288
genes like me logo Genes that share ontologies with ATG7: view

Drugs & Compounds for ATG7 Gene

(1) Additional Compounds for ATG7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATG7: view

Transcripts for ATG7 Gene

Unigene Clusters for ATG7 Gene

Autophagy related 7:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG7 Gene

No ASD Table

Relevant External Links for ATG7 Gene

GeneLoc Exon Structure for
ATG7
ECgene alternative splicing isoforms for
ATG7

Expression for ATG7 Gene

mRNA expression in normal human tissues for ATG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATG7 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for ATG7 Gene

This gene is overexpressed in Esophagus (6.5), Peripheral blood mononuclear cells (6.1), and Frontal cortex (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ATG7 Gene



Protein tissue co-expression partners for ATG7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ATG7 Gene:

ATG7

SOURCE GeneReport for Unigene cluster for ATG7 Gene:

Hs.38032

mRNA Expression by UniProt/SwissProt for ATG7 Gene:

O95352-ATG7_HUMAN
Tissue specificity: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
genes like me logo Genes that share expression patterns with ATG7: view

Primer Products

Orthologs for ATG7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATG7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG7 34 35
  • 97.9 (n)
dog
(Canis familiaris)
Mammalia ATG7 34 35
  • 91.65 (n)
oppossum
(Monodelphis domestica)
Mammalia ATG7 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATG7 34 35
  • 88.48 (n)
rat
(Rattus norvegicus)
Mammalia Atg7 34
  • 86.99 (n)
mouse
(Mus musculus)
Mammalia Atg7 34 16 35
  • 86.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATG7 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG7 34 35
  • 77.43 (n)
lizard
(Anolis carolinensis)
Reptilia ATG7 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg7 34
  • 70.97 (n)
zebrafish
(Danio rerio)
Actinopterygii ATG7 35
  • 73 (a)
OneToOne
atg7 34
  • 68.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta Atg7 34 35
  • 50.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010303 34
  • 47.71 (n)
worm
(Caenorhabditis elegans)
Secernentea atg-7 34 35
  • 51.02 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER298C 34
  • 51.35 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05137g 34
  • 49.6 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG7 34 35 37
  • 49.29 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons APG7 34
  • 53.65 (n)
rice
(Oryza sativa)
Liliopsida Os01g0614900 34
  • 48.2 (n)
Os.1041 34
bread mold
(Neurospora crassa)
Ascomycetes NCU06672 34
  • 50.31 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atg7 34
  • 50.16 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.887 34
Species where no ortholog for ATG7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG7 Gene

ENSEMBL:
Gene Tree for ATG7 (if available)
TreeFam:
Gene Tree for ATG7 (if available)

Paralogs for ATG7 Gene

No data available for Paralogs for ATG7 Gene

Variants for ATG7 Gene

Sequence variations from dbSNP and Humsavar for ATG7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000010 -- 11,562,645(-) GGGGC(C/T)GAGGC intron-variant
rs1046593 -- 11,554,928(+) CAGGC(C/T)TGGTG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1046595 -- 11,554,937(+) TGATT(C/T)TGGGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10557675 -- 11,390,760(+) ACTGC(-/AAG)TTAAA intron-variant
rs10558538 -- 11,334,631(+) TAAAA(-/TG)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG7 Gene

Variant ID Type Subtype PubMed ID
dgv113n6 CNV deletion 16902084
dgv1359e212 CNV loss 25503493
dgv762e201 CNV deletion 23290073
esv1000938 CNV deletion 20482838
esv1566288 CNV deletion 17803354
esv2657088 CNV deletion 23128226
esv2659742 CNV deletion 23128226
esv26665 CNV loss 19812545
esv2676397 CNV deletion 23128226
esv2677845 CNV deletion 23128226
esv2724910 CNV deletion 23290073
esv2724911 CNV deletion 23290073
esv2760731 CNV loss 21179565
esv3561470 CNV deletion 23714750
esv3595290 CNV loss 21293372
esv3595291 CNV loss 21293372
esv3595292 CNV loss 21293372
esv3595293 CNV loss 21293372
esv3595294 CNV loss 21293372
esv4117 OTHER complex 18987735
esv9285 CNV gain 19470904
esv998828 CNV deletion 20482838
nsv1002727 CNV loss 25217958
nsv1073204 CNV deletion 25765185
nsv1109493 CNV deletion 24896259
nsv1114352 CNV deletion 24896259
nsv1118963 CNV deletion 24896259
nsv1121603 CNV deletion 24896259
nsv3698 CNV insertion 18451855
nsv436362 CNV deletion 17901297
nsv436869 CNV insertion 17901297
nsv437323 CNV loss 16327808
nsv517831 CNV loss 19592680
nsv527441 CNV gain 19592680
nsv955314 CNV deletion 24416366
nsv963549 CNV deletion 23825009

Variation tolerance for ATG7 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG7 Gene

Human Gene Mutation Database (HGMD)
ATG7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG7 Gene

Disorders for ATG7 Gene

Relevant External Links for ATG7

Genetic Association Database (GAD)
ATG7
Human Genome Epidemiology (HuGE) Navigator
ATG7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG7

No disorders were found for ATG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG7 Gene

Publications for ATG7 Gene

  1. Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein. (PMID: 10233149) Yuan W. … Dunn W.A. Jr. (Mol. Biol. Cell 1999) 2 3 4 22 64
  2. Regulation of autophagy by the p300 acetyltransferase. (PMID: 19124466) Lee I.H. … Finkel T. (J. Biol. Chem. 2009) 3 4 22 64
  3. Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7). (PMID: 23386620) Desai S. … Tan M. (J. Biol. Chem. 2013) 3 4 64
  4. The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation. (PMID: 22170151) Tanida I. … Ueno T. (Autophagy 2012) 3 4 64
  5. Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. (PMID: 19881538) Zhu K. … McConkey D.J. (Oncogene 2010) 3 22 64

Products for ATG7 Gene

Sources for ATG7 Gene

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