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Aliases for ATG7 Gene

Aliases for ATG7 Gene

  • Autophagy Related 7 2 3 5
  • Ubiquitin-Activating Enzyme E1-Like Protein 2 3 4
  • ATG12-Activating Enzyme E1 ATG7 3 4
  • APG7-LIKE 3 4
  • APG7L 3 4
  • HAGP7 3 4
  • ATG7 Autophagy Related 7 Homolog (S. Cerevisiae) 2
  • APG7 Autophagy 7-Like (S. Cerevisiae) 2
  • Autophagy-Related Protein 7 4
  • GSA7 3

External Ids for ATG7 Gene

Previous HGNC Symbols for ATG7 Gene

  • APG7L

Previous GeneCards Identifiers for ATG7 Gene

  • GC03P011290

Summaries for ATG7 Gene

Entrez Gene Summary for ATG7 Gene

  • This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for ATG7 Gene

ATG7 (Autophagy Related 7) is a Protein Coding gene. Diseases associated with ATG7 include Vici Syndrome. Among its related pathways are p53 Pathway (RnD) and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include protein homodimerization activity and ubiquitin activating enzyme activity.

UniProtKB/Swiss-Prot for ATG7 Gene

  • E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

Gene Wiki entry for ATG7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG7 Gene

Genomics for ATG7 Gene

Regulatory Elements for ATG7 Gene

Enhancers for ATG7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATG7 on UCSC Golden Path with GeneCards custom track

Promoters for ATG7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATG7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATG7 Gene

Chromosome:
3
Start:
11,272,309 bp from pter
End:
11,557,665 bp from pter
Size:
285,357 bases
Orientation:
Plus strand

Genomic View for ATG7 Gene

Genes around ATG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG7 Gene

Proteins for ATG7 Gene

  • Protein details for ATG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95352-ATG7_HUMAN
    Recommended name:
    Ubiquitin-like modifier-activating enzyme ATG7
    Protein Accession:
    O95352
    Secondary Accessions:
    • B4E170
    • E9PB95
    • Q7L8L0
    • Q9BWP2
    • Q9UFH4

    Protein attributes for ATG7 Gene

    Size:
    703 amino acids
    Molecular mass:
    77960 Da
    Quaternary structure:
    • Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Forms intermediate conjugates with ATG8-like proteins such as GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A. Interacts with EP300 acetyltransferase. Interacts with FOXO1.

    Alternative splice isoforms for ATG7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG7 Gene

Proteomics data for ATG7 Gene at MOPED

Post-translational modifications for ATG7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ATG7 (ATG7)

No data available for DME Specific Peptides for ATG7 Gene

Domains & Families for ATG7 Gene

Protein Domains for ATG7 Gene

Suggested Antigen Peptide Sequences for ATG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95352

UniProtKB/Swiss-Prot:

ATG7_HUMAN :
  • The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.
  • Belongs to the ATG7 family.
Domain:
  • The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.
  • The N-terminal FAP motif (residues 15 to 17) is essential for the formation of the ATG89-PE and ATG5-ATG12 conjugates.
Family:
  • Belongs to the ATG7 family.
genes like me logo Genes that share domains with ATG7: view

Function for ATG7 Gene

Molecular function for ATG7 Gene

UniProtKB/Swiss-Prot Function:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
UniProtKB/Swiss-Prot Induction:
Expression is up-regulated by the transcription factor HSF1.

Gene Ontology (GO) - Molecular Function for ATG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11096062
GO:0042803 protein homodimerization activity IDA 11096062
genes like me logo Genes that share ontologies with ATG7: view
genes like me logo Genes that share phenotypes with ATG7: view

Animal Models for ATG7 Gene

MGI Knock Outs for ATG7:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATG7 Gene

Localization for ATG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG7 Gene

Cytoplasm. Preautophagosomal structure. Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG7 Gene COMPARTMENTS Subcellular localization image for ATG7 gene
Compartment Confidence
cytosol 5
lysosome 3
mitochondrion 3
nucleus 3
vacuole 3
endoplasmic reticulum 2
cytoskeleton 1
endosome 1
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ATG7 Gene

Pathways & Interactions for ATG7 Gene

genes like me logo Genes that share pathways with ATG7: view

Pathways by source for ATG7 Gene

SIGNOR curated interactions for ATG7 Gene

Gene Ontology (GO) - Biological Process for ATG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10233149
GO:0006497 protein lipidation IDA 12890687
GO:0006501 C-terminal protein lipidation IBA --
GO:0006914 autophagy IEA --
GO:0006995 cellular response to nitrogen starvation IBA --
genes like me logo Genes that share ontologies with ATG7: view

Drugs & Compounds for ATG7 Gene

(1) Additional Compounds for ATG7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ATG7: view

Transcripts for ATG7 Gene

Unigene Clusters for ATG7 Gene

Autophagy related 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATG7 Gene

No ASD Table

Relevant External Links for ATG7 Gene

GeneLoc Exon Structure for
ATG7
ECgene alternative splicing isoforms for
ATG7

Expression for ATG7 Gene

mRNA expression in normal human tissues for ATG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATG7 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for ATG7 Gene

This gene is overexpressed in Esophagus (6.5), Peripheral blood mononuclear cells (6.1), and Frontal cortex (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG7 Gene



SOURCE GeneReport for Unigene cluster for ATG7 Gene Hs.38032

mRNA Expression by UniProt/SwissProt for ATG7 Gene

O95352-ATG7_HUMAN
Tissue specificity: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
genes like me logo Genes that share expression patterns with ATG7: view

Protein tissue co-expression partners for ATG7 Gene

- Elite partner

Primer Products

Orthologs for ATG7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATG7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATG7 35
  • 88.48 (n)
  • 94.31 (a)
ATG7 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG7 35
  • 91.65 (n)
  • 95.02 (a)
ATG7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg7 35
  • 86.31 (n)
  • 93.13 (a)
Atg7 16
Atg7 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATG7 35
  • 97.9 (n)
  • 97.36 (a)
ATG7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg7 35
  • 86.99 (n)
  • 93.4 (a)
oppossum
(Monodelphis domestica)
Mammalia ATG7 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG7 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG7 35
  • 77.43 (n)
  • 84.36 (a)
ATG7 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG7 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg7 35
  • 70.97 (n)
  • 77.94 (a)
zebrafish
(Danio rerio)
Actinopterygii atg7 35
  • 68.55 (n)
  • 73.88 (a)
ATG7 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010303 35
  • 47.71 (n)
  • 41.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atg7 35
  • 50.61 (n)
  • 43.73 (a)
Atg7 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea atg-7 35
  • 51.02 (n)
  • 44.72 (a)
atg-7 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER298C 35
  • 51.35 (n)
  • 46.8 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05137g 35
  • 49.6 (n)
  • 45.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG7 35
  • 49.29 (n)
  • 42.97 (a)
ATG7 36
  • 41 (a)
OneToOne
ATG7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons APG7 35
  • 53.65 (n)
  • 49.02 (a)
rice
(Oryza sativa)
Liliopsida Os.1041 35
Os01g0614900 35
  • 48.2 (n)
  • 36.88 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.887 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06672 35
  • 50.31 (n)
  • 46.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes atg7 35
  • 50.16 (n)
  • 44.89 (a)
Species with no ortholog for ATG7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG7 Gene

ENSEMBL:
Gene Tree for ATG7 (if available)
TreeFam:
Gene Tree for ATG7 (if available)

Paralogs for ATG7 Gene

No data available for Paralogs for ATG7 Gene

Variants for ATG7 Gene

Sequence variations from dbSNP and Humsavar for ATG7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs36117895 - 11,358,545(+) TGTCG(C/T)CTTCC nc-transcript-variant, reference, missense
rs8154 -- 11,554,828(+) AGCGA(C/T)GATGA nc-transcript-variant, reference, synonymous-codon
rs14016 -- 11,554,874(+) CTCCC(C/T)GGCCG nc-transcript-variant, utr-variant-3-prime
rs346077 -- 11,284,416(+) AGGCT(A/C)CTTAT intron-variant
rs346078 -- 11,286,154(+) tgtct(C/G)tttgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG7 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735
nsv876535 CNV Gain 21882294
esv1566288 CNV Deletion 17803354
nsv527441 CNV Gain 19592680
nsv437323 CNV Loss 16327808
esv2724910 CNV Deletion 23290073
esv2659742 CNV Deletion 23128226
esv26665 CNV Loss 19812545
dgv113n6 CNV Loss 16902084
esv998828 CNV Deletion 20482838
esv2676397 CNV Deletion 23128226
dgv5107n71 CNV Loss 21882294
esv2677845 CNV Deletion 23128226
nsv3698 CNV Insertion 18451855
esv2657088 CNV Deletion 23128226
esv9285 CNV Gain 19470904
nsv517831 CNV Loss 19592680
esv1000938 CNV Deletion 20482838
esv2724911 CNV Deletion 23290073

Variation tolerance for ATG7 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG7 Gene

Human Gene Mutation Database (HGMD)
ATG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG7 Gene

Disorders for ATG7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATG7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vici syndrome
  • immunodeficiency with cleft lip/palate, cataract, hypopigmentation, and absent corpus callosum
- elite association - COSMIC cancer census association via MalaCards
Search ATG7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATG7

Genetic Association Database (GAD)
ATG7
Human Genome Epidemiology (HuGE) Navigator
ATG7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG7
genes like me logo Genes that share disorders with ATG7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATG7 Gene

Publications for ATG7 Gene

  1. Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein. (PMID: 10233149) Yuan W. … Dunn W.A. Jr. (Mol. Biol. Cell 1999) 2 3 4 23 67
  2. Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. (PMID: 19881538) Zhu K. … McConkey D.J. (Oncogene 2010) 3 23
  3. Regulation of autophagy by the p300 acetyltransferase. (PMID: 19124466) Lee I.H. … Finkel T. (J. Biol. Chem. 2009) 3 23
  4. PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. (PMID: 19148225) N'Diaye E.N. … Brown E.J. (EMBO Rep. 2009) 3 23
  5. Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes. (PMID: 25339774) Sagnier S. … Espert L. (J. Virol. 2015) 3

Products for ATG7 Gene

Sources for ATG7 Gene

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