Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATG7 Gene

protein-coding   GIFtS: 60
GCID: GC03P011313

autophagy related 7

(Previous names: APG7 autophagy 7-like (S. cerevisiae), ATG7 autophagy related...)
(Previous symbol: APG7L)
 Explore 19 diseases affiliated with
ATG7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATG7    

Aliases
for ATG7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Autophagy Related 71 2     APG7 Autophagy 7-Like (S. Cerevisiae)1
APG7L1 2 3     ATG7 Autophagy Related 7 Homolog (S. Cerevisiae)1
GSA71 2     APG7-LIKE2
Autophagy-Related Protein 72 3     ATG7 Autophagy Related 7 Homolog2
Ubiquitin-Activating Enzyme E1-Like Protein2 3     Ubiquitin Activating Enzyme E1-Like Protein2
ATG12-Activating Enzyme E1 ATG72 3     Ubiquitin-Like Modifier-Activating Enzyme ATG72
HAGP71     APG7-Like1
DKFZp434N07351     

External Ids:    HGNC: 169351   Entrez Gene: 105332   Ensembl: ENSG000001975487   OMIM: 6087605   UniProtKB: O953523   

Export aliases for ATG7 gene to outside databases

Previous GC identifer: GC03P011290


Summaries
for ATG7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ATG7:
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the
protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the
ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: ATG7_HUMAN, O95352
Function: Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms
intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to
ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By
similarity)

Gene Wiki entry for ATG7


Genomic Views
for ATG7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATG7 gene promoter:
         Pax-5   AML1a   GCNF   MIF-1   GATA-1   GCNF-1   c-Myb   STAT3   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATG7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATG7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3-p25.2

ATG7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P011313:  view genomic region     (about GC identifiers)

Start:
 11,313,995 bp from pter      End:
 11,599,139 bp from pter
Size:
 285,145 bases      Orientation:
 plus strand

Proteins
for ATG7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATG7_HUMAN, O95352 (See protein sequence)
Recommended Name: Ubiquitin-like modifier-activating enzyme ATG7  
Size: 703 amino acids; 77960 Da
Subunit: Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role
in the conjugation of ATG12 to ATG5
Subcellular location: Cytoplasm (Probable)
Secondary accessions: B4E170 E9PB95 Q7L8L0 Q9BWP2 Q9UFH4
Alternative splicing: 3 isoforms:  O95352-1   O95352-2   O95352-3   

Explore the universe of human proteins at neXtProt for ATG7: NX_O95352

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95352

    • ATG7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129503.2  NP_001138384.1  NP_006386.1  

    ENSEMBL proteins: 
     ENSP00000415223   ENSP00000390547   ENSP00000411880   ENSP00000389996   ENSP00000389012  
     ENSP00000412580   ENSP00000347042   ENSP00000346437   ENSP00000408303   ENSP00000416644  
     ENSP00000409844   ENSP00000393075   ENSP00000407340   ENSP00000388295   ENSP00000406398  
    Reactome Protein details: O95352
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ATG7
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ATG7
    OriGene Protein Over-expression Lysate: ATG7
    OriGene Custom Protein Services for ATG7 
    GenScript Custom Purified and Recombinant Proteins Services for ATG7
    Novus Biologicals ATG7 Proteins
    Novus Biologicals ATG7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ATG7

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--


    ATG7 for ontologies           About GeneDecksing



    ATG7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATG7
    R&D Systems Antibodies for ATG7
    Cell Signaling Technology (CST) Antibodies for ATG7 
    OriGene Antibodies (see all 3): ATG7
    OriGene Custom Antibody Services for ATG7 
    GenScript Custom Superior Antibodies Services for ATG7
    Novus Biologicals ATG7 Antibodies
    Abcam antibodies for ATG7 
    Uscn Antibodies for ATG7
    ThermoFisher Antibodies for ATG7

    Assay Products for ATG7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATG7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ATG7

    Protein Domains /
    Families
    for ATG7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATG7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006285 Atg7
     IPR009036 Molybdenum_cofac_synth_MoeB
     IPR000594 ThiF_NAD_FAD-bd
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry O95352

    ProtoNet protein and cluster: O95352

    1 Blocks protein family: IPB000594 UBA/THIF-type NAD/FAD binding fold

    UniProtKB/Swiss-Prot: ATG7_HUMAN, O95352
    Domain: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By
    similarity)
    Similarity: Belongs to the ATG7 family


    Function
    for ATG7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATG7_HUMAN, O95352
    Function: Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms
    intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to
    ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By
    similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): ATG7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATG7
    8/107 QIAGEN miScript miRNA Assays for microRNAs that regulate ATG7 (see all 107):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-4254 hsa-miR-520e hsa-miR-146a hsa-miR-106a hsa-miR-200a hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmid: ATG7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG7 (see all 7)
    OriGene shRNA RFP: ATG7
    OriGene siRNA: ATG7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ATG7

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG7 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG7 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): ATG7 (NM_006395)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG7 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ATG7
    Search LifeMap BioReagents cell lines for ATG7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG7

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003824catalytic activity ----
    GO:0004839ubiquitin activating enzyme activity IEA--
    GO:0005515protein binding IPI--
    GO:0019778APG12 activating enzyme activity ISS--


    ATG7 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ATG7:
     Decreased p24 protein expressi  Increased cell number in G1, a 

    Animal Models:
         Mouse knock-out Atg7tm1.1Tchi for ATG7
         10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Atg7):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  liver/biliary system  mortality/aging  nervous system 

    ATG7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATG7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Class I MHC mediated antigen processing & presentation0.83
    3Protein Stability
    		Protein Stability1.00
    4Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    5Senescence and Autophagy
    		Senescence and Autophagy1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ATG7
        Apoptosis and Autophagy
    Protein Stability

    1 BioSystems Pathway for ATG7 
        Senescence and Autophagy

    4        Reactome Pathways for ATG7
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for ATG7):
        Regulation of autophagy


    ATG7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/142 Interacting proteins for ATG7 (O953521, 3 ENSP000003464374) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1DP296921, 3EBI-987834,EBI-748782 I2D: score=1 
    GABARAPL2P605201, 3, ENSP000000372434EBI-987834,EBI-2973440 I2D: score=7 STRING: ENSP00000037243
    GABARAPO951661, 3, ENSP000003068664EBI-987834,EBI-712001 I2D: score=7 STRING: ENSP00000306866
    MAP1LC3BQ9GZQ81, 3, ENSP000002686074EBI-987834,EBI-373144 I2D: score=5 STRING: ENSP00000268607
    IRF2P143161, 3, ENSP000003772184EBI-987834,EBI-3918980 I2D: score=1 STRING: ENSP00000377218
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006464cellular protein modification process TAS10233149
    GO:0006497protein lipidation IDA12890687
    GO:0006520cellular amino acid metabolic process IEA--
    GO:0006914autophagy IEA--


    ATG7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATG7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATG7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATG7
    1 Novoseek chemical compound relationship for ATG7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 22.8 1 14976209 (1)

    Search CenterWatch for drugs/clinical trials and news about ATG7 

    Transcripts
    for ATG7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATG7 gene (3 alternative transcripts): 
    NM_001136031.2  NM_001144912.1  NM_006395.2  

    Unigene Cluster for ATG7:

    Autophagy related 7
    Hs.38032  [show with all ESTs]
    Unigene Representative Sequence: NM_006395
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000451513 ENST00000435760 ENST00000451830 ENST00000460444 ENST00000470474
    ENST00000444619 ENST00000418682 ENST00000446450 ENST00000354956 ENST00000354449(uc003bwc.3 uc003bwd.3 uc011aum.2)
    ENST00000419112 ENST00000469654 ENST00000423116 ENST00000488924 ENST00000464282
    ENST00000424071 ENST00000434066 ENST00000478638

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): ATG7
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATG7
    8/107 QIAGEN miScript miRNA Assays for microRNAs that regulate ATG7 (see all 107):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-4254 hsa-miR-520e hsa-miR-146a hsa-miR-106a hsa-miR-200a hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmid: ATG7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG7 (see all 7)
    OriGene shRNA RFP: ATG7
    OriGene siRNA: ATG7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG7 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG7 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): ATG7 (NM_006395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG7 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATG7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG7

    Additional cDNA sequence: 

    AF094516.1 AK075221.1 AK298833.1 AK303694.1 AK314504.1 AL122075.1 BC000091.2 BC014319.1 

    24/27 DOTS entries (see all 27):

    DT.95155731  DT.95155732  DT.120922055  DT.40116097  DT.92448622  DT.100823029  DT.92448576  DT.100823036 
    DT.95188558  DT.100823022  DT.101954993  DT.95107467  DT.100038018  DT.92448616  DT.92448620  DT.95310478 
    DT.99989863  DT.120921943  DT.120922021  DT.120922151  DT.40119105  DT.92448580  DT.97856284  DT.100701137 

    24/129 AceView cDNA sequences (see all 129):

    BG683101 AI203185 AA398736 AI183490 AU280438 CB112450 BU186678 AL553049 
    BM686614 BX102476 BP373819 AI568649 AL576155 BU727987 CD622591 AK075221 
    AI272953 AI964058 BM547442 W16773 AL520089 CB130936 CD245333 BG250765 

    GeneLoc Exon Structure


    Expression
    for ATG7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATG7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCGATGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ATG7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATG7

    SOURCE GeneReport for Unigene cluster: Hs.38032

    UniProtKB/Swiss-Prot: ATG7_HUMAN, O95352
    Tissue specificity: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow

        SABiosciences Expression via Pathway-Focused PCR Arrays including ATG7: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Autophagy in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATG7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG7

    Orthologs
    for ATG7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATG7 gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Atg71 , 5 autophagy-related 7 (yeast)5
    autophagy related 71    		 86.31(n)1
    93.13(a)1    		   6 (53.05 cM)5
    742441  NM_001253717.11  NP_001240646.11 
     1146430975 
    chicken
    (Gallus gallus)    		 Aves ATG71 ATG7 autophagy related 7 homolog (S. cerevisiae) 77.43(n)
    84.36(a)    		   415961  NM_001030592.1  NP_001025763.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ATG76
    		 --
    		 82(a)
    		 1 ↔ 1
    		 2(157922855-158010385)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01066378.16
    		 --
    		 73(a)
    		 1 ↔ 1
    		 11(831071-882330)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Atg71 Autophagy-specific gene 7 50.1(n)
    43.6(a)    		   37141  NM_137506.2  NP_611350.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea atg-71 Protein ATG-7 50.92(n)
    44.57(a)    		   178005  NM_069663.2  NP_502064.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ATG7(YHR171W)4
    ATG71    		 Autophagy-related protein and dual specificity member more4
    Atg7p1    		 49.56(n)1
    43.42(a)1    		   8(445713-447605)4
    8565761, 4  NP_012041.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons APG71 ubiquitin-like modifier-activating enzyme atg7 53.41(n)
    48.8(a)    		   834630  NM_123958.2  NP_568652.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.10412 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.37(n)    AK067422.1 


    ENSEMBL Gene Tree for ATG7 (if available)
    TreeFam Gene Tree for ATG7 (if available) 

    Paralogs
    for ATG7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ATG7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4939 NCBI SNPs in ATG7 are shown (see all 4939)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs730117861,2
    		C,F,--11312094(+) TTAACC/TAAACT 3 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1433339671,2
    		--11312123(+) TTTCCC/GCAGGC 3 -- us2k10--------
    rs1475458541,2
    		--11312204(+) ACAGGA/CTTTGT 3 -- us2k10--------
    rs593237901,2
    		--11312221(+) AACAAA/GGCTGT 3 -- us2k10--------
    rs1438841291,2
    		--11312345(+) TTTTGC/GGGGTA 3 -- us2k10--------
    rs1918207361,2
    		--11312355(+) AGGGGA/GTGGAT 3 -- us2k10--------
    rs1843207091,2
    		--11312435(+) AAGAAC/GCTTCT 3 -- us2k10--------
    rs1115952481,2
    		--11312440(+) CCTTCC/TTAAGG 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1397863741,2
    		--11312504(+) ACAATG/TGTGGA 3 -- us2k10--------
    rs1122872061,2
    		--11312691(+) TCTGAT/ACAAGC 3 -- us2k12Minor allele frequency- A:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for ATG7 (11313995 - 11563995 bp, first 250kb of ATG7)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for ATG7
         5 CNVs: 6159 63393 6158 91190 91189
         3 Indels: 27134 60406 10733
    Human Gene Mutation Database (HGMD): ATG7

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG7
    DNA2.0 Custom Variant and Variant Library Synthesis for ATG7

    Disorders / Diseases
    for ATG7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATG7 for disorders           About GeneDecksing

    OMIM gene information: 608760    OMIM disorders: --

    19 diseases for ATG7:    About MalaCards
    chronic obstructive pulmonary disease    frontotemporal dementia    acute promyelocytic leukemia    pulmonary disease
    hepatitis c    dementia    huntington's disease    neurodegeneration
    lung cancer    prostate cancer    breast cancer    myeloma
    hepatitis    leukemia    cerebritis    retinitis
    prostatitis    malaria    neuronitis

    1 Novoseek disease relationship for ATG7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 9.01 1 10709110 (1)

    Human Genome Epidemiology (HuGE) Navigator: ATG7 (3 documents)

    Export disorders for ATG7 gene to outside databases

    Publications
    for ATG7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATG7 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with ATG7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein. (PubMed id 10233149)1, 2, 3, 9 Yuan W.... Dunn W.A. Jr. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs. (PubMed id 11890701)1, 2 Tanida I.... Kominami E. (2002)
    4. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. (PubMed id 11825910)1, 2 Tanida I.... Kominami E. (2002)
    5. Regulation of autophagy by the p300 acetyltransferase. (PubMed id 19124466)1, 9 Lee I.H. and Finkel T. (2009)
    6. Proteasome inhibitors activate autophagy as a cytopro tective response in human prostate cancer cells. (PubMed id 19881538)1, 9 Zhu K....McConkey D.J. (2010)
    7. PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. (PubMed id 19148225)1, 9 N'Diaye E.N....Brown E.J. (2009)
    8. Autophagy-related gene 7 (ATG7) and reactive oxygen sp ecies/extracellular signal-regulated kinase regulate tetrandrine-induced autopha gy in human hepatocellular carcinoma. (PubMed id 22927446)1 Gong K....Li W. (2012)
    9. The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation. (PubMed id 22170151)1 Tanida I....Ueno T. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for ATG7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ATG7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10533 HGNC: 16935 AceView: APG7L Ensembl:ENSG00000197548 euGenes: HUgn10533
    ECgene: ATG7 Kegg: 10533 H-InvDB: ATG7

    Other Databases showing ATG7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATG7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATG7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATG7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATG7 gene:
    Search GeneIP for patents involving ATG7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ATG7 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of ATG7
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ATG7 (ATG7)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for ATG7 (ATG7)  
     OriGene Antibodies for ATG7   OriGene shRNA RFP for ATG7  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG7   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG7  
     OriGene Protein Over-expression Lysate for ATG7   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ATG7   OriGene 3'-UTR Clone for ATG7  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG7   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG7  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ATG7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATG7   OriGene Custom Protein Services for ATG7  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATG7
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG7
     GenScript Custom Purified and Recombinant Proteins Services for ATG7 GenScript cDNA clones with any tag delivered in your preferred vector for ATG7
     GenScript Custom Assay Services for ATG7 GenScript Custom Superior Antibodies Services for ATG7
     GenScript Custom overexpressing Cell Line Services for ATG7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for ATG7 

     Regulatory tfbs in ATG7 promoter
     Search Chromatin IP Primers for ATG7
     RT2 qPCR Primer Assay in human, mouse, rat ATG7
     Search GNC Networks for ATG7
     SABiosciences PCR Arrays including human, mouse, rat ATG7
     Search Tocris compounds for ATG7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ATG7 antibodies
     ATG7 proteins
     ATG7 lysates
     Antibodies for ATG7
     See all of Abcam's Antibodies, Kits and Proteins for ATG7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ATG7 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ATG7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG7
     SwitchGear 3'UTR luciferase reporter plasmids for ATG7
     SwitchGear Promoter luciferase reporter plasmids for ATG7
     ThermoFisher Antibodies for ATG7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG7
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ATG7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4