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ATG7 Gene

protein-coding   GIFtS: 63
GCID: GC03P011313

Autophagy Related 7

(Previous names: APG7 autophagy 7-like (S. cerevisiae), ATG7 autophagy related...)
(Previous symbol: APG7L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Autophagy Related 71 2     APG7 Autophagy 7-Like (S. Cerevisiae)1
APG7L1 2 3 5     ATG7 Autophagy Related 7 Homolog (S. Cerevisiae)1
Ubiquitin-Activating Enzyme E1-Like Protein1 2 3     APG7-LIKE2
Autophagy-Related Protein 72 3     ATG7 Autophagy Related 7 Homolog2
ATG12-Activating Enzyme E1 ATG72 3     Ubiquitin Activating Enzyme E1-Like Protein2
hAGP72 3     Ubiquitin-Like Modifier-Activating Enzyme ATG72
GSA72 5     APG7-like3

External Ids:    HGNC: 169351   Entrez Gene: 105332   Ensembl: ENSG000001975487   OMIM: 6087605   UniProtKB: O953523   

Export aliases for ATG7 gene to outside databases

Previous GC identifer: GC03P011290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATG7 Gene:
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the
yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows
homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. (provided by RefSeq, Jan
2009)

GeneCards Summary for ATG7 Gene:
ATG7 (autophagy related 7) is a protein-coding gene. Diseases associated with ATG7 include frontotemporal dementia, and acute promyelocytic leukemia. GO annotations related to this gene include APG12 activating enzyme activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: ATG7_HUMAN, O95352
Function: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole
transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins
for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt
vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required
for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to
a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53
activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of
axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the
formation of Paneth cell granules, as well as in adipose differentiation

Gene Wiki entry for ATG7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATG7 gene promoter:
         Pax-5   AML1a   GCNF   MIF-1   GATA-1   GCNF-1   c-Myb   STAT3   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG7 promoter sequence
   Search Chromatin IP Primers for ATG7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATG7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3-p25.2

ATG7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P011313:  view genomic region     (about GC identifiers)

Start:
11,313,995 bp from pter      End:
11,599,139 bp from pter
Size:
285,145 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATG7_HUMAN, O95352 (See protein sequence)
Recommended Name: Ubiquitin-like modifier-activating enzyme ATG7  
Size: 703 amino acids; 77960 Da
Subunit: Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the
conjugation of ATG12 to ATG5. Forms intermediate conjugates with ATG8-like proteins such as GABARAP, GABARAPL1,
GABARAPL2 or MAP1LC3A. Interacts with EP300 acetyltransferase
Secondary accessions: B4E170 E9PB95 Q7L8L0 Q9BWP2 Q9UFH4
Alternative splicing: 3 isoforms:  O95352-1   O95352-2   O95352-3   

Explore the universe of human proteins at neXtProt for ATG7: NX_O95352

Explore proteomics data for ATG7 at MOPED

Post-translational modifications: 

  • Acetylated by EP3001
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ATG7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129503.2  NP_001138384.1  NP_006386.1  

    ENSEMBL proteins: 
     ENSP00000415223   ENSP00000390547   ENSP00000411880   ENSP00000389996   ENSP00000389012  
     ENSP00000412580   ENSP00000347042   ENSP00000346437   ENSP00000408303   ENSP00000416644  
     ENSP00000409844   ENSP00000393075   ENSP00000407340   ENSP00000388295   ENSP00000406398  
    Reactome Protein details: O95352

    ATG7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ATG7
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ATG7
    OriGene Protein Over-expression Lysate for ATG7
    OriGene MassSpec for ATG7
    OriGene Custom Protein Services for ATG7
    GenScript Custom Purified and Recombinant Proteins Services for ATG7
    Novus Biologicals ATG7 Proteins
    Novus Biologicals ATG7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ATG7

    ATG7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATG7
    R&D Systems Antibodies for ATG7
    Cell Signaling Technology (CST) Antibodies for ATG7 
    OriGene Antibodies for ATG7
    OriGene Custom Antibody Services for ATG7
    Novus Biologicals ATG7 Antibodies
    Abcam antibodies for ATG7
    Cloud-Clone Corp. Antibodies for ATG7
    ThermoFisher Antibody for ATG7
    LSBio Antibodies in human, mouse, rat for ATG7

    ATG7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATG7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATG7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATG7
    Cloud-Clone Corp. CLIAs for ATG7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE1: Ubiquitin-like modifier activating enzymes

    4 InterPro protein domains:
     IPR006285 Atg7
     IPR009036 Molybdenum_cofac_synth_MoeB
     IPR000594 ThiF_NAD_FAD-bd
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry O95352

    ProtoNet protein and cluster: O95352

    1 Blocks protein domain: IPB000594 UBA/THIF-type NAD/FAD binding fold

    UniProtKB/Swiss-Prot: ATG7_HUMAN, O95352
    Domain: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12
    (By similarity)
    Domain: The N-terminal FAP motif (residues 15 to 17) is essential for the formation of the ATG89-PE and ATG5-ATG12
    conjugates (PubMed:22170151)
    Similarity: Belongs to the ATG7 family


    ATG7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATG7_HUMAN, O95352
    Function: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole
    transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins
    for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt
    vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required
    for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to
    a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53
    activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of
    axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the
    formation of Paneth cell granules, as well as in adipose differentiation
    Induction: Expression is up-regulated by the transcription factor HSF1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004839ubiquitin activating enzyme activity IEA--
    GO:0005515protein binding IPI11096062
    GO:0019778APG12 activating enzyme activity ISS--
    GO:0042803protein homodimerization activity IDA11096062
         
    ATG7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ATG7:
     Decreased p24 protein expressi  Increased cell number in G1, a 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Atg7):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  liver/biliary system  mortality/aging  nervous system 

    ATG7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Atg7tm1.1Tchi for ATG7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATG7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATG7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATG7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATG7

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATG7:
    hsa-mir-320c (MIRT036161), hsa-mir-375 (MIRT020034)

    Block miRNA regulation of human, mouse, rat ATG7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATG7 (see all 107):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-4254 hsa-miR-520e hsa-miR-146a hsa-miR-106a hsa-miR-200a hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidATG7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATG7
    Predesigned siRNA for gene silencing in human, mouse, rat ATG7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATG7

    Clone
    Products:
         
    OriGene clones in human, mouse for ATG7 (see all 17)
    OriGene ORF clones in mouse, rat for ATG7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ATG7 (NM_006395)
    Sino Biological Human cDNA Clone for ATG7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATG7
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATG7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATG7_HUMAN, O95352: Cytoplasm (By similarity). Preautophagosomal structure (By similarity). Note=Localizes also
    to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    vacuole3
    endoplasmic reticulum2
    lysosome2
    mitochondrion2
    endosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000407pre-autophagosomal structure IEA--
    GO:0005737cytoplasm TAS10233149
    GO:0005930axoneme ISS--

    ATG7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATG7 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    2Senescence and Autophagy
    Senescence and Autophagy
    3Regulation of autophagy
    Regulation of autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ATG7
        Senescence and Autophagy


    1 Reactome Pathway for ATG7
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for ATG7):
        Regulation of autophagy


    ATG7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATG7: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Autophagy in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATG7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATG7 (O953521, 3 ENSP000003464374) via UniProtKB, MINT, STRING, and/or I2D (see all 179)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006464cellular protein modification process TAS10233149
    GO:0006497protein lipidation IDA12890687
    GO:0006520cellular amino acid metabolic process IEA--
    GO:0006914autophagy IEA--

    ATG7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATG7

    1 Novoseek inferred chemical compound relationship for ATG7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 22.8 1 14976209 (1)



    ATG7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATG7 gene (3 alternative transcripts): 
    NM_001136031.2  NM_001144912.1  NM_006395.2  

    Unigene Cluster for ATG7:

    Autophagy related 7
    Hs.38032  [show with all ESTs]
    Unigene Representative Sequence: NM_006395
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000451513 ENST00000435760 ENST00000451830 ENST00000460444 ENST00000470474
    ENST00000444619 ENST00000418682 ENST00000446450 ENST00000354956 ENST00000354449(uc003bwc.3 uc003bwd.3 uc011aum.2)
    ENST00000419112 ENST00000469654 ENST00000423116 ENST00000488924 ENST00000464282
    ENST00000424071 ENST00000434066 ENST00000478638
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATG7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATG7 (see all 107):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-4254 hsa-miR-520e hsa-miR-146a hsa-miR-106a hsa-miR-200a hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidATG7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATG7
    Predesigned siRNA for gene silencing in human, mouse, rat ATG7
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ATG7 (NM_006395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG7
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ATG7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG7
      QuantiTect SYBR Green Assays in human, mouse, rat ATG7
      QuantiFast Probe-based Assays in human, mouse, rat ATG7

    Additional mRNA sequence: 

    AF094516.1 AK075221.1 AK298833.1 AK303694.1 AK314504.1 AL122075.1 BC000091.2 BC014319.1 

    Selected DOTS entries (see all 27):

    DT.95155731  DT.95155732  DT.120922055  DT.40116097  DT.92448622  DT.100823029  DT.92448576  DT.100823036 
    DT.95188558  DT.100823022  DT.101954993  DT.95107467  DT.100038018  DT.92448616  DT.92448620  DT.95310478 
    DT.99989863  DT.120921943  DT.120922021  DT.120922151  DT.40119105  DT.92448580  DT.97856284  DT.100701137 

    Selected AceView cDNA sequences (see all 129):

    AI964058 AK075221 AI272953 BU727987 AI568649 BM686614 BP373819 AI203185 
    BX102476 AL553049 AL576155 AA398736 AI183490 BU186678 BG683101 CB112450 
    AU280438 CD622591 CD245333 AI633549 CA421304 BG250765 NM_006395 BM922182 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ATG7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGATGATG
    ATG7 Expression
    About this image


    ATG7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    ATG7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATG7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.38032

    UniProtKB/Swiss-Prot: ATG7_HUMAN, O95352
    Tissue specificity: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATG7: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Autophagy in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ATG7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG7
    QuantiTect SYBR Green Assays in human, mouse, rat ATG7
    QuantiFast Probe-based Assays in human, mouse, rat ATG7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATG7 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg71 , 5 autophagy-related 7 (yeast)5
    autophagy related 71
    86.31(n)1
    93.13(a)1
      6 (53.05 cM)5
    742441  NM_001253717.11  NP_001240646.11 
     1146430975 
    chicken
    (Gallus gallus)
    Aves ATG71 autophagy related 7 77.43(n)
    84.36(a)
      415961  NM_001030592.1  NP_001025763.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATG76
    autophagy related 7
    84(a)
    1 ↔ 1
    2(157934343-158078618)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atg71 autophagy related 7 70.97(n)
    77.94(a)
      100170158  NM_001129922.1  NP_001123394.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atg71 ATG7 autophagy related 7 homolog (S. cerevisiae) 68.55(n)
    73.88(a)
      100333016  XM_005172762.1  XP_005172819.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atg71 Autophagy-specific gene 7 50.61(n)
    43.73(a)
      37141  NM_137506.3  NP_611350.1 
    worm
    (Caenorhabditis elegans)
    Secernentea atg-71 atg-7 51.02(n)
    44.72(a)
      178005  NM_069663.3  NP_502064.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG7(YHR171W)4
    ATG71
    Autophagy-related protein and dual specificity member more4
    ATG71
    49.29(n)1
    42.97(a)1
      8(445713-447605)4
    8565761, 4  NP_012041.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APG71 APG7 53.65(n)
    49.02(a)
      834630  NM_123958.2  NP_568652.1 
    rice
    (Oryza sativa)
    Liliopsida Os.10412 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.37(n)    AK067422.1 


    ENSEMBL Gene Tree for ATG7 (if available)
    TreeFam Gene Tree for ATG7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATG7 (see all 5798)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730117861,2
    C,F--11312094(+) TTAACC/TAAACT 3 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1433339671,2
    --11312123(+) TTTCCC/GCAGGC 3 -- us2k10--------
    rs1475458541,2
    C--11312204(+) ACAGGA/CTTTGT 3 -- us2k10--------
    rs593237901,2
    --11312221(+) AACAAA/GGCTGT 3 -- us2k10--------
    rs1438841291,2
    --11312345(+) TTTTGC/GGGGTA 3 -- us2k10--------
    rs1918207361,2
    --11312355(+) AGGGGA/GTGGAT 3 -- us2k10--------
    rs1843207091,2
    --11312435(+) AAGAAC/GCTTCT 3 -- us2k10--------
    rs1115952481,2
    C--11312440(+) CCTTCC/TTAAGG 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1397863741,2
    --11312504(+) ACAATG/TGTGGA 3 -- us2k10--------
    rs1122872061,2
    F--11312691(+) TCTGAT/ACAAGC 3 -- us2k12Minor allele frequency- A:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for ATG7 (11313995 - 11563995 bp, first 250kb of ATG7)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ATG7 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676397CNV Deletion23128226
    esv1566288CNV Deletion17803354
    dgv809e201CNV Deletion23290073
    esv2724911CNV Deletion23290073
    esv2657088CNV Deletion23128226
    esv998828CNV Deletion20482838
    nsv436362CNV Deletion17901297
    esv2677845CNV Deletion23128226
    esv2724910CNV Deletion23290073
    esv2659742CNV Deletion23128226

    Human Gene Mutation Database (HGMD): ATG7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATG7
    DNA2.0 Custom Variant and Variant Library Synthesis for ATG7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608760    OMIM disorders: --

    Selected diseases for ATG7 (see all 21):    
    About MalaCards
    frontotemporal dementia    acute promyelocytic leukemia    dementia    huntington's disease
    hepatitis c virus    osteosarcoma    hepatitis c    myeloma
    parkinson's disease    cerebritis    retinitis    hepatocellular carcinoma
    hepatitis    lung cancer    prostatitis    hiv-1
    prostate cancer    leukemia    breast cancer    neuronitis


    ATG7 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ATG7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 9.01 1 10709110 (1)

    Genetic Association Database (GAD): ATG7
    Human Genome Epidemiology (HuGE) Navigator: ATG7 (3 documents)

    Export disorders for ATG7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATG7 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with ATG7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein. (PubMed id 10233149)1, 2, 3, 9 Yuan W.... Dunn W.A. Jr. (Mol. Biol. Cell 1999)
    2. Regulation of autophagy by the p300 acetyltransferase. (PubMed id 19124466)1, 2, 9 Lee I.H. and Finkel T. (J. Biol. Chem. 2009)
    3. Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7). (PubMed id 23386620)1, 2 Desai S....Tan M. (J. Biol. Chem. 2013)
    4. The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation. (PubMed id 22170151)1, 2 Tanida I....Ueno T. (Autophagy 2012)
    5. Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. (PubMed id 20697744)1, 4 Metzger S....Nguyen H.P. (Hum. Genet. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. (PubMed id 16303767)1, 2 Sou Y.S....Kominami E. (J. Biol. Chem. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs. (PubMed id 11890701)1, 2 Tanida I.... Kominami E. (Biochem. Biophys. Res. Commun. 2002)
    10. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. (PubMed id 11825910)1, 2 Tanida I.... Kominami E. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10533 HGNC: 16935 AceView: APG7L Ensembl:ENSG00000197548 euGenes: HUgn10533
    ECgene: ATG7 Kegg: 10533 H-InvDB: ATG7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATG7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ATG7 gene:
    Search GeneIP for patents involving ATG7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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