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Aliases for ATG5 Gene

Aliases for ATG5 Gene

  • Autophagy Related 5 2 3
  • APG5L 3 4 6
  • Apoptosis-Specific Protein 3 4
  • APG5-LIKE 3 4
  • ASP 3 4
  • ATG5 Autophagy Related 5 Homolog (S. Cerevisiae) 2
  • APG5 (Autophagy 5, S. Cerevisiae)-Like 2
  • APG5 Autophagy 5-Like (S. Cerevisiae) 2
  • ATG5 Autophagy Related 5 Homolog 3
  • Autophagy Protein 5 3
  • HAPG5 3
  • APG5 3

External Ids for ATG5 Gene

Previous Symbols for ATG5 Gene

  • APG5L

Summaries for ATG5 Gene

GeneCards Summary for ATG5 Gene

ATG5 (Autophagy Related 5) is a Protein Coding gene. Among its related pathways are Salmonella infection (KEGG) and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.

UniProtKB/Swiss-Prot for ATG5 Gene

  • Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway

  • May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD

Gene Wiki entry for ATG5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG5 Gene

Genomics for ATG5 Gene

Genomic Location for ATG5 Gene

Start:
106,184,476 bp from pter
End:
106,325,820 bp from pter
Size:
141,345 bases
Orientation:
Minus strand

Genomic View for ATG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG5 Gene

Regulatory Elements for ATG5 Gene

Proteins for ATG5 Gene

  • Protein details for ATG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1Y0-ATG5_HUMAN
    Recommended name:
    Autophagy protein 5
    Protein Accession:
    Q9H1Y0
    Secondary Accessions:
    • O60875
    • Q5JVR2
    • Q68DI4
    • Q9H2B8
    • Q9HCZ7

    Protein attributes for ATG5 Gene

    Size:
    275 amino acids
    Molecular mass:
    32447 Da
    Quaternary structure:
    • Forms a conjugate with ATG12. The ATG5-ATG12 conjugate forms a complex with several units of ATG16L. Interacts with TECPR1; the interaction is direct and does not take place when ATG16L is associated with the ATG5-ATG12 conjugate. ATG12-ATG5 interacts with MAVS, MGA and RARRES3. Interacts with ATG3, ATG7 and ATG10. Interacts with FADD. Interacts transiently interacts with hepatitis C virus (HCV) protein NS5B during HCV infection.

    Three dimensional structures from OCA and Proteopedia for ATG5 Gene

    Alternative splice isoforms for ATG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG5 Gene

Proteomics data for ATG5 Gene at MOPED

Post-translational modifications for ATG5 Gene

  • Acetylated by EP300.
  • Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG5 Gene

No data available for DME Specific Peptides for ATG5 Gene

Domains for ATG5 Gene

Protein Domains for ATG5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1Y0

UniProtKB/Swiss-Prot:

ATG5_HUMAN
Family:
  • Belongs to the ATG5 family.:
    • Q9H1Y0
genes like me logo Genes that share domains with ATG5: view

No data available for Gene Families for ATG5 Gene

Function for ATG5 Gene

Molecular function for ATG5 Gene

UniProtKB/Swiss-Prot Function: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway
UniProtKB/Swiss-Prot Function: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD
UniProtKB/Swiss-Prot Induction: By apoptotic stimuli

Gene Ontology (GO) - Molecular Function for ATG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11096062
GO:0019776 contributes_to Atg8 ligase activity IBA --
genes like me logo Genes that share ontologies with ATG5: view
genes like me logo Genes that share phenotypes with ATG5: view

Animal Models for ATG5 Gene

MGI Knock Outs for ATG5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ATG5 Gene

Localization for ATG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG5 Gene

Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG5 Gene COMPARTMENTS Subcellular localization image for ATG5 gene
Compartment Confidence
vacuole 5
cytosol 3
lysosome 3
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for ATG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005776 autophagic vacuole IDA 15292400
GO:0005930 axoneme ISS --
GO:0016020 membrane IDA 23093945
GO:0034045 pre-autophagosomal structure membrane ISS --
genes like me logo Genes that share ontologies with ATG5: view

Pathways for ATG5 Gene

genes like me logo Genes that share pathways with ATG5: view

Pathways by source for ATG5 Gene

Gene Ontology (GO) - Biological Process for ATG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly ISS --
GO:0000422 mitochondrion degradation IBA --
GO:0001974 blood vessel remodeling IEA --
GO:0002739 regulation of cytokine secretion involved in immune response IEA --
GO:0006501 C-terminal protein lipidation IBA --
genes like me logo Genes that share ontologies with ATG5: view

Compounds for ATG5 Gene

(3) Novoseek inferred chemical compound relationships for ATG5 Gene

Compound -log(P) Hits PubMed IDs
3-methyladenine 88.9 2
wortmannin 35.4 1
cycloheximide 24.7 1
genes like me logo Genes that share compounds with ATG5: view

Transcripts for ATG5 Gene

Unigene Clusters for ATG5 Gene

Autophagy related 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATG5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2:
SP3: -
SP4: - -
SP5: - - - -

Relevant External Links for ATG5 Gene

GeneLoc Exon Structure for
ATG5
ECgene alternative splicing isoforms for
ATG5

Expression for ATG5 Gene

mRNA expression in normal human tissues for ATG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG5 Gene

SOURCE GeneReport for Unigene cluster for ATG5 Gene Hs.486063

mRNA Expression by UniProt/SwissProt for ATG5 Gene

Q9H1Y0-ATG5_HUMAN
Tissue specificity: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells
genes like me logo Genes that share expressions with ATG5: view

No data available for mRNA differential expression in normal tissues for ATG5 Gene

Orthologs for ATG5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG5 35
  • 100 (n)
  • 100 (a)
ATG5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATG5 35
  • 95.27 (n)
  • 97.82 (a)
ATG5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG5 35
  • 95.64 (n)
  • 99.27 (a)
ATG5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg5 35
  • 91.76 (n)
  • 96.73 (a)
Atg5 16
Atg5 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATG5 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG5 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG5 35
  • 84.73 (n)
  • 89.82 (a)
ATG5 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG5 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23730 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atg5 35
  • 78.64 (n)
  • 84.85 (a)
Str.17181 35
zebrafish
(Danio rerio)
Actinopterygii atg5 35
  • 73.87 (n)
  • 82.05 (a)
atg5 36
  • 81 (a)
OneToOne
Dr.12686 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010939 35
  • 55.77 (n)
  • 53.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atg5 35
  • 54.58 (n)
  • 50 (a)
Atg5 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea atg-5 35
  • 49.1 (n)
  • 38.46 (a)
atg-5 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG5 36
  • 25 (a)
OneToOne
ATG5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons APG5 35
  • 46.92 (n)
  • 35.09 (a)
rice
(Oryza sativa)
Liliopsida Os02g0117800 35
  • 44.83 (n)
  • 35.06 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7077 36
  • 46 (a)
OneToOne
Species with no ortholog for ATG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG5 Gene

ENSEMBL:
Gene Tree for ATG5 (if available)
TreeFam:
Gene Tree for ATG5 (if available)

Paralogs for ATG5 Gene

Selected SIMAP similar genes for ATG5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ATG5: view

No data available for Paralogs for ATG5 Gene

Variants for ATG5 Gene

Sequence variations from dbSNP and Humsavar for ATG5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14503 -- 106,185,978(-) GTAAC(A/T)TTGAT utr-variant-3-prime, nc-transcript-variant
rs473543 -- 106,327,811(-) GAAAA(C/T)GGTCA upstream-variant-2KB
rs478310 -- 106,217,877(+) TATTT(C/T)AGATT intron-variant
rs484621 -- 106,286,533(+) ATGAT(C/T)TCCAC intron-variant
rs490010 -- 106,292,583(-) GTAGA(C/T)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG5 Gene

Variant ID Type Subtype PubMed ID
dgv391n21 CNV Gain 19592680
esv26469 CNV Gain 19812545
esv2615044 CNV Insertion 19546169
esv2657202 CNV Deletion 23128226
esv2677509 CNV Deletion 23128226
esv24511 CNV Loss 19812545

Relevant External Links for ATG5 Gene

HapMap Linkage Disequilibrium report
ATG5
Human Gene Mutation Database (HGMD)
ATG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG5 Gene

Disorders for ATG5 Gene

(1) University of Copenhagen DISEASES for ATG5 Gene

(2) Novoseek inferred disease relationships for ATG5 Gene

Disease -log(P) Hits PubMed IDs
shock 11.2 2
necrosis 0 1

Relevant External Links for ATG5

Genetic Association Database (GAD)
ATG5
Human Genome Epidemiology (HuGE) Navigator
ATG5
genes like me logo Genes that share disorders with ATG5: view

No data available for UniProtKB/Swiss-Prot for ATG5 Gene

Publications for ATG5 Gene

  1. Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast. (PMID: 9563500) Hammond E.M. … Grand R.J.A. (FEBS Lett. 1998) 2 3 4 23
  2. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. (PMID: 15778222) Pyo J.O. … Jung Y.K. (J. Biol. Chem. 2005) 2 3 4 23
  3. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. (PMID: 9852036) Mizushima N. … Ohsumi Y. (J. Biol. Chem. 1998) 3 4 23
  4. Regulation of autophagy by the p300 acetyltransferase. (PMID: 19124466) Lee I.H. … Finkel T. (J. Biol. Chem. 2009) 3 4 23
  5. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. (PMID: 19197948) Kang M.R. … Lee S.H. (J. Pathol. 2009) 3 23 48

Products for ATG5 Gene

  • Addgene plasmids for ATG5

Sources for ATG5 Gene

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