Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ATG5 Gene

protein-coding   GIFtS: 65
GCID: GC06M106632

Autophagy Related 5

(Previous names: APG5 (autophagy 5, S. cerevisiae)-like, APG5 autophagy 5-like...)
(Previous symbol: APG5L)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Autophagy Related 51 2     APG52
APG5L1 2 3 5     APG5-LIKE2
Apoptosis-Specific Protein2 3     ATG5 Autophagy Related 5 Homolog2
ASP2 3     Autophagy Protein 52
APG5 (Autophagy 5, S. Cerevisiae)-Like1     hAPG52
APG5 Autophagy 5-Like (S. Cerevisiae)1     APG5-like3
ATG5 Autophagy Related 5 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 5891   Entrez Gene: 94742   Ensembl: ENSG000000576637   OMIM: 6042615   UniProtKB: Q9H1Y03   

Export aliases for ATG5 gene to outside databases

Previous GC identifers: GC06M106740 GC06M104079


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ATG5 Gene:
ATG5 (autophagy related 5) is a protein-coding gene.

UniProtKB/Swiss-Prot: ATG5_HUMAN, Q9H1Y0
Function: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating
system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential
for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8
family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after
oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the
innate antiviral immune response by blocking the type I IFN production pathway through direct association with
RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation
apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T
lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II.
Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte
differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation
of IFT20 via the autophagic pathway
Function: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its
expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a
crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD

Gene Wiki entry for ATG5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATG5 gene promoter:
         SRF   p53   SRF (504 AA)   HNF-3beta   POU3F2   RORalpha2   FOXJ2 (long isoform)   FOXJ2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG5 promoter sequence
   Search Chromatin IP Primers for ATG5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

ATG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M106632:  view genomic region     (about GC identifiers)

Start:
106,632,351 bp from pter      End:
106,773,695 bp from pter
Size:
141,345 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ATG5_HUMAN, Q9H1Y0 (See protein sequence)
Recommended Name: Autophagy protein 5  
Size: 275 amino acids; 32447 Da
Subunit: Forms a conjugate with ATG12. The ATG5-ATG12 conjugate forms a complex with several units of ATG16L.
Interacts with TECPR1; the interaction is direct and does not take place when ATG16L is associated with the
ATG5-ATG12 conjugate. ATG12-ATG5 interacts with MAVS, MGA and RARRES3. Interacts with ATG3, ATG7 and ATG10.
Interacts with FADD. Interacts transiently interacts with hepatitis C virus (HCV) protein NS5B during HCV
infection
3 PDB 3D structures from and Proteopedia for ATG5:
4GDK (3D)        4GDL (3D)        4NAW (3D)    
Secondary accessions: O60875 Q5JVR2 Q68DI4 Q9H2B8 Q9HCZ7
Alternative splicing: 2 isoforms:  Q9H1Y0-1   Q9H1Y0-2   

Explore the universe of human proteins at neXtProt for ATG5: NX_Q9H1Y0

Explore proteomics data for ATG5 at MOPED

Post-translational modifications: 

  • Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane1
  • Acetylated by EP3001
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ATG5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001273035.1  NP_001273036.1  NP_001273037.1  NP_001273040.1  NP_004840.1  

    ENSEMBL proteins: 
     ENSP00000343313   ENSP00000358072   ENSP00000358066   ENSP00000353884  
    Reactome Protein details: Q9H1Y0

    ATG5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ATG5
    OriGene Protein Over-expression Lysate for ATG5
    OriGene MassSpec for ATG5
    OriGene Custom Protein Services for ATG5
    GenScript Custom Purified and Recombinant Proteins Services for ATG5
    Novus Biologicals ATG5 Proteins
    Novus Biologicals ATG5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ATG5
    Cloud-Clone Corp. Proteins for ATG5

     
    Search eBioscience for Proteins for ATG5 

    ATG5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATG5
    R&D Systems Antibodies for ATG5
    Cell Signaling Technology (CST) Antibodies for ATG5 
    OriGene Antibodies for ATG5
    OriGene Custom Antibody Services for ATG5
    Novus Biologicals ATG5 Antibodies
    Search for Antibodies for ATG5 at Abcam
    Cloud-Clone Corp. Antibodies for ATG5
    ThermoFisher Antibody for ATG5
    LSBio Antibodies in human, mouse, rat for ATG5

    ATG5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATG5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATG5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATG5
    Cloud-Clone Corp. CLIAs for ATG5
    Search eBioscience for ELISAs for ATG5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007239 Atg5

    Graphical View of Domain Structure for InterPro Entry Q9H1Y0

    ProtoNet protein and cluster: Q9H1Y0

    1 Blocks protein domain: IPB007239 Autophagy protein Apg5

    UniProtKB/Swiss-Prot: ATG5_HUMAN, Q9H1Y0
    Similarity: Belongs to the ATG5 family


    Find genes that share domains with ATG5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATG5_HUMAN, Q9H1Y0
    Function: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating
    system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential
    for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8
    family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after
    oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the
    innate antiviral immune response by blocking the type I IFN production pathway through direct association with
    RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation
    apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T
    lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II.
    Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte
    differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation
    of IFT20 via the autophagic pathway
    Function: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its
    expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a
    crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD
    Induction: By apoptotic stimuli

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11096062
         
    Find genes that share ontologies with ATG5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ATG5:
     Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Atg5) (see all 18):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  muscle  nervous system  normal 

    Find genes that share phenotypes with ATG5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Atg5tm1Nmz for ATG5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATG5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATG5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATG5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATG5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ATG5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATG5 (see all 13):
    hsa-miR-30c hsa-miR-299-5p hsa-miR-3607-3p hsa-miR-216b hsa-miR-30d hsa-miR-4282 hsa-miR-3647-3p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidATG5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATG5
    Predesigned siRNA for gene silencing in human, mouse, rat ATG5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATG5

    Clone
    Products:
         
    OriGene clones in human, mouse for ATG5 (see all 6)
    OriGene ORF clones in mouse, rat for ATG5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATG5 (NM_004849)
    Sino Biological Human cDNA Clone for ATG5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG5
    Addgene plasmids for ATG5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ATG5
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATG5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG5

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12125) for ATG5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ATG5_HUMAN, Q9H1Y0: Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein.
    Note=Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after
    autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary
    axoneme and to the base of the ciliary axoneme
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole5
    cytosol3
    lysosome3
    endoplasmic reticulum2
    mitochondrion2
    nucleus2
    plasma membrane2
    cytoskeleton1
    endosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005776autophagic vacuole IDA15292400
    GO:0005930axoneme ISS--
    GO:0034045pre-autophagosomal structure membrane ISS--

    Find genes that share ontologies with ATG5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ATG5 About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    RIG-I-like receptor signaling pathway0.47
    2Salmonella infection (KEGG)
    Shigellosis0.30
    3Senescence and Autophagy
    Senescence and Autophagy
    4Regulation of autophagy
    Regulation of autophagy


    Find genes that share SuperPaths with ATG5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ATG5
        Senescence and Autophagy


    1 Reactome Pathway for ATG5
        Negative regulators of RIG-I/MDA5 signaling


    3 Kegg Pathways  (Kegg details for ATG5):
        Regulation of autophagy
    RIG-I-like receptor signaling pathway
    Shigellosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATG5: 
              Antiviral Response in human mouse rat
              Autophagy in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATG5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATG5 (Q9H1Y01, 2, 3 ENSP000003433134) via UniProtKB, MINT, STRING, and/or I2D (see all 511)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ISS--
    GO:0001974blood vessel remodeling IEA--
    GO:0002739regulation of cytokine secretion involved in immune response IEA--
    GO:0006914autophagy ISS--
    GO:0006915apoptotic process IEA--

    Find genes that share ontologies with ATG5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATG5

    3 Novoseek inferred chemical compound relationships for ATG5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-methyladenine 88.9 2 15657430 (1), 19115482 (1)
    wortmannin 35.4 1 19115482 (1)
    cycloheximide 24.7 1 7796880 (1)



    Find genes that share compounds with ATG5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ATG5 gene (5 alternative transcripts): 
    NM_001286106.1  NM_001286107.1  NM_001286108.1  NM_001286111.1  NM_004849.3  

    Unigene Cluster for ATG5:

    Autophagy related 5
    Hs.486063  [show with all ESTs]
    Unigene Representative Sequence: Y11588
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475645 ENST00000343245 ENST00000369076(uc003prf.3 uc010kdb.3)
    ENST00000369070(uc003prg.3 uc010kdc.3) ENST00000476518 ENST00000360666

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATG5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ATG5 (see all 13):
    hsa-miR-30c hsa-miR-299-5p hsa-miR-3607-3p hsa-miR-216b hsa-miR-30d hsa-miR-4282 hsa-miR-3647-3p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidATG5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATG5
    Predesigned siRNA for gene silencing in human, mouse, rat ATG5
    Clone
    Products:
         
    OriGene clones in human, mouse for ATG5 (see all 6)
    OriGene ORF clones in mouse, rat for ATG5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ATG5 (NM_004849)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG5
    Addgene plasmids for ATG5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ATG5
    OriGene qSTAR qPCR primer pairs in human, mouse for ATG5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG5
      QuantiTect SYBR Green Assays in human, mouse, rat ATG5
      QuantiFast Probe-based Assays in human, mouse, rat ATG5
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12125) for ATG5 

    Additional mRNA sequence: 

    AF293841.1 AK001899.1 AK299577.1 AK315800.1 BC002699.2 BC093011.1 BX537904.1 CR749386.1 
    EU283338.1 EU283339.1 JQ918353.1 JQ918354.1 JQ924061.1 Y11588.1 

    13 DOTS entries:

    DT.316534  DT.86852491  DT.100773368  DT.100773367  DT.100773370  DT.316536  DT.95184690  DT.102823419 
    DT.91844873  DT.100045110  DT.121325660  DT.40131866  DT.95259264 

    Selected AceView cDNA sequences (see all 214):

    BX537904 T63304 BI256848 AI377501 CR749386 BU679973 AI921939 AW967448 
    BI759140 AA558459 BU622727 AL541395 AI990740 AK001899 AU136457 CB044559 
    BM980196 BF001735 BP377689 BP357784 AI420472 BM852617 BM838049 BM128085 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ATG5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -                                                               
    SP2:                                                                                    
    SP3:                                -                                                   
    SP4:                    -           -                                                   
    SP5:                    -           -     -     -                                       


    ECgene alternative splicing isoforms for ATG5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ATG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ATG5 Expression
    About this image


    ATG5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ATG5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATG5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.486063

    UniProtKB/Swiss-Prot: ATG5_HUMAN, Q9H1Y0
    Tissue specificity: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the
    protein is dramatically highly expressed in apoptotic cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ATG5: 
              Antiviral Response in human mouse rat
              Autophagy in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ATG5
    OriGene qSTAR qPCR primer pairs in human, mouse for ATG5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG5
    QuantiTect SYBR Green Assays in human, mouse, rat ATG5
    QuantiFast Probe-based Assays in human, mouse, rat ATG5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATG5 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg51 , 5 autophagy-related 5 (yeast)5
    autophagy related 51
    91.76(n)1
    96.73(a)1
      10 (23.24 cM)5
    117931  NM_053069.51  NP_444299.11 
     442683585 
    chicken
    (Gallus gallus)
    Aves ATG51 autophagy related 5 84.73(n)
    89.82(a)
      421784  NM_001006409.1  NP_001006409.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATG56
    autophagy related 5
    90(a)
    1 ↔ 1
    1(189204532-189241708)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237302 Xenopus laevis transcribed sequence with moderate similarity more 79.15(n)    BI477654.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.126862 Danio rerio clone RK112A2A05 APG5 autophagy 5-like more 74(n)    AY398310.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atg51 Autophagy-specific gene 5 54.58(n)
    50(a)
      31666  NM_132162.3  NP_572390.1 
    worm
    (Caenorhabditis elegans)
    Secernentea atg-51 atg-5 49.1(n)
    38.46(a)
      171735  NM_058484.5  NP_490885.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG5(YPL149W)4 Conserved protein involved in autophagy and the Cvt more   --   16(271310-272194) 855954  NP_015176.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APG51 APG5 46.92(n)
    35.09(a)
      831594  NM_121735.4  NP_197231.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01178001 Os02g0117800 44.83(n)
    35.06(a)
      4328092  NM_001052225.1  NP_001045690.1 


    ENSEMBL Gene Tree for ATG5 (if available)
    TreeFam Gene Tree for ATG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ATG5 gene
    1 SIMAP similar gene for ATG5 using alignment to 4 protein entries:     ATG5_HUMAN (see all proteins):
    DKFZp686F0183

    Find genes that share paralogs with ATG5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ATG5 (see all 2562)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362434
    A colorectal cancer sample4--see VAR_0362432 K M mis40--------
    rs104845751,2
    C,F,H--106631860(+) AAATCC/TTGGTG 1 -- ds500133Minor allele frequency- T:0.14NS EA NA WA CSA 3080
    rs1917187251,2
    --106631952(+) CAAAAA/GTATAA 1 -- ds50010--------
    rs579014431,2
    C--106631967(+) TTTTT-/TATCCT 1 -- ds50010--------
    rs782005521,2
    C--106631967(+) GTGGAT/CTTTTT 1 -- ds50014Minor allele frequency- C:0.18NA WA EA 360
    rs1511653281,2
    --106631996(+) ATATTA/GCTATT 1 -- ds50010--------
    rs1390548231,2
    --106631997(+) TATTGA/CTATTT 1 -- ds50010--------
    rs750160101,2
    C,F--106632045(+) TCCATG/TGTCAT 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1439742061,2
    --106632195(+) TCAAAC/TAGGCA 1 -- ds50010--------
    rs1842682201,2
    --106632260(+) TATTTC/TTCCAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ATG5 (106632351 - 106773695 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ATG5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677509CNV Deletion23128226
    esv2657202CNV Deletion23128226
    esv2615044CNV Insertion19546169
    esv24511CNV Loss19812545
    dgv391n21CNV Gain19592680
    esv26469CNV Gain19812545

    Human Gene Mutation Database (HGMD): ATG5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATG5
    DNA2.0 Custom Variant and Variant Library Synthesis for ATG5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604261    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ATG5:
    Cancer

    Find genes that share disorders with ATG5           About GenesLikeMe

    2 Novoseek inferred disease relationships for ATG5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 11.2 2 9596416 (1), 7796880 (1)
    necrosis 0 1 20431342 (1)

    Genetic Association Database (GAD): ATG5
    Human Genome Epidemiology (HuGE) Navigator: ATG5 (8 documents)

    Export disorders for ATG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ATG5 gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with ATG5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. (PubMed id 15778222)1, 2, 3, 9 Pyo J.O....Jung Y.K. (J. Biol. Chem. 2005)
    2. Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast. (PubMed id 9563500)1, 2, 3, 9 Hammond E.M.... Grand R.J.A. (FEBS Lett. 1998)
    3. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. (PubMed id 19197948)1, 4, 9 Kang M.R....Lee S.H. (J. Pathol. 2009)
    4. Regulation of autophagy by the p300 acetyltransferase. (PubMed id 19124466)1, 2, 9 Lee I.H. and Finkel T. (J. Biol. Chem. 2009)
    5. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. (PubMed id 9852036)1, 2, 9 Mizushima N.... Ohsumi Y. (J. Biol. Chem. 1998)
    6. A novel protein expressed in mammalian cells undergoing apoptosis. (PubMed id 7796880)1, 2, 9 Grand R.J.A.... Gregory C.D. (Exp. Cell Res. 1995)
    7. Structure of the human ATG12-ATG5 conjugate required for LC3 lipidation in autophagy. (PubMed id 23202584)1, 2 Otomo C.... Otomo T. (Nat. Struct. Mol. Biol. 2013)
    8. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. (PubMed id 22342342)1, 2 Chen D.... Zhong Q. (Mol. Cell 2012)
    9. Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan. (PubMed id 22170153)1, 2 Mai S....Jendrach M. (Autophagy 2012)
    10. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (Genes Immun. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9474 HGNC: 589 AceView: APG5L Ensembl:ENSG00000057663 euGenes: HUgn9474
    ECgene: ATG5 Kegg: 9474 H-InvDB: ATG5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ATG5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ATG5 gene:
    Search GeneIP for patents involving ATG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ATG5
     
     EMD Millipore genomic analysis products

      
     Antibodies for ATG5 (ATG5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ATG5   OriGene RNAi products in human, mouse, rat for ATG5  
     OriGene qPCR primer pairs and template standards for ATG5   OriGene Protein Over-expression Lysate for ATG5  
     OriGene MassSpec something-or-other for ATG5   OriGene clones in human, mouse for ATG5  
     OriGene qSTAR qPCR primer pairs in human, mouse for ATG5   OriGene Purified Protein for ATG5  
     OriGene ORF clones in mouse, rat for ATG5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ATG5   OriGene Custom Protein Services for ATG5  

     
     
     Block miRNA regulation of human, mouse, rat ATG5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ATG5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATG5 Predesigned siRNA for gene silencing in human, mouse, rat ATG5
     QuantiFast Probe-based Assays in human, mouse, rat ATG5 QuantiTect SYBR Green Assays in human, mouse, rat ATG5
     PCR Arrays including human, mouse, rat ATG5 Search Chromatin IP Primers for ATG5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG5  Search GeneGlobe Interaction Network for ATG5
     Regulatory tfbs in ATG5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ATG5 GenScript cDNA clones with any tag delivered in your preferred vector for ATG5
     GenScript Custom Assay Services for ATG5 GenScript Custom overexpressing Cell Line Services for ATG5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ATG5 

     Search Tocris compounds for ATG5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ATG5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ATG5 antibodies
     ATG5 proteins
     ATG5 lysates
     Search for Antibodies for ATG5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ATG5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ATG5
     Proteins for ATG5
     Antibodies for ATG5
     ELISAs for ATG5
     CLIAs for ATG5



     Browse ESI BIO Cell Lines and PureStem Progenitors for ATG5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG5
     SwitchGear 3'UTR luciferase reporter plasmids for ATG5
     SwitchGear Promoter luciferase reporter plasmids for ATG5
     ThermoFisher Antibody for ATG5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATG5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATG5
     LSBio Antibodies in human, mouse, rat for ATG5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for ATG5
      Search eBioscience for proteins for ATG5
      Search eBioscience for elisas for ATG5
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ATG5 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4