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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATG5 Gene

protein-coding   GIFtS: 62
GCID: GC06M106632

autophagy related 5

(Previous names: APG5 (autophagy 5, S. cerevisiae)-like, APG5 autophagy...)
(Previous symbol: APG5L)
 Explore 28 diseases affiliated with
ATG5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATG5    

Aliases
for ATG5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Autophagy Related 51 2     APG5 Autophagy 5-Like (S. Cerevisiae)1
APG5L1 2 3 5     ATG5 Autophagy Related 5 Homolog (S. Cerevisiae)1
ASP1 2 3     APG5-LIKE2
APG51 2     Apoptosis Specific Protein2
HAPG51     ATG5 Autophagy Related 5 Homolog2
Apoptosis-Specific Protein2 3     Autophagy Protein 52
APG5 (Autophagy 5, S. Cerevisiae)-Like1     APG5-Like1

External Ids:    HGNC: 5891   Entrez Gene: 94742   Ensembl: ENSG000000576637   OMIM: 6042615   UniProtKB: Q9H1Y03   

Export aliases for ATG5 gene to outside databases

Previous GC identifers: GC06M106740 GC06M104079


Summaries
for ATG5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ATG5_HUMAN, Q9H1Y0
Function: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped
isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after
autophagosome formation is completed (By similarity)
Function: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its
expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity

Gene Wiki entry for ATG5


Genomic Views
for ATG5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATG5 gene promoter:
         SRF   p53   SRF (504 AA)   HNF-3beta   POU3F2   RORalpha2   FOXJ2 (long isoform)   FOXJ2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATG5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATG5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

ATG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M106632:  view genomic region     (about GC identifiers)

Start:
 106,632,351 bp from pter      End:
 106,773,695 bp from pter
Size:
 141,345 bases      Orientation:
 minus strand

Proteins
for ATG5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATG5_HUMAN, Q9H1Y0 (See protein sequence)
Recommended Name: Autophagy protein 5  
Size: 275 amino acids; 32447 Da
Subunit: The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction
is direct and does not take place when ATG16 is associated with the ATG5-ATG12 conjugate
Subcellular location: Cytoplasm. Note=Colocalizes with nonmuscle actin
2 PDB 3D structures from and Proteopedia for ATG5:
4GDK (3D)        4GDL (3D)    
Secondary accessions: O60875 Q5JVR2 Q68DI4 Q9H2B8 Q9HCZ7
Alternative splicing: 2 isoforms:  Q9H1Y0-1   Q9H1Y0-2   

Explore the universe of human proteins at neXtProt for ATG5: NX_Q9H1Y0

Post-translational modifications:

  • Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H1Y0

    • ATG5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004840.1  
    ENSEMBL proteins: 
     ENSP00000358072   ENSP00000343313   ENSP00000358066   ENSP00000353884  
    Reactome Protein details: Q9H1Y0
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for ATG5
    Uscn Proteins for ATG5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005776autophagic vacuole IDA15292400
    GO:0034045pre-autophagosomal structure membrane ISS--
    GO:0043234protein complex ----


    ATG5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ATG5

    Protein Domains /
    Families
    for ATG5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATG5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007239 Atg5

    Graphical View of Domain Structure for InterPro Entry Q9H1Y0

    ProtoNet protein and cluster: Q9H1Y0

    1 Blocks protein family: IPB007239 Autophagy protein Apg5

    UniProtKB/Swiss-Prot: ATG5_HUMAN, Q9H1Y0
    Similarity: Belongs to the ATG5 family


    Function
    for ATG5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATG5_HUMAN, Q9H1Y0
    Function: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped
    isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after
    autophagosome formation is completed (By similarity)
    Function: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its
    expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity
    Induction: By apoptotic stimuli

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate ATG5 (see all 13):
    hsa-miR-30c hsa-miR-299-5p hsa-miR-3607-3p hsa-miR-216b hsa-miR-30d hsa-miR-4282 hsa-miR-3647-3p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: ATG5 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    ATG5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ATG5:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Atg5tm1Nmz for ATG5
         15/18 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Atg5) (see all 18):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  muscle  nervous system  normal 

    ATG5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATG5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways1.00
    		Negative regulators of RIG-I/MDA5 signaling0.49
    		RIG-I-like receptor signaling pathway0.52
    2Immune System
    		Immune System1.00
    		Innate Immune System0.46
    3Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    4Senescence and Autophagy
    		Senescence and Autophagy1.00
    5Shigellosis
    		Shigellosis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ATG5
        Apoptosis and Autophagy

    1 BioSystems Pathway for ATG5 
        Senescence and Autophagy

    4        Reactome Pathways for ATG5
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling
    Immune System
    Innate Immune System


    3         Kegg Pathways  (Kegg details for ATG5):
        Regulation of autophagy
    RIG-I-like receptor signaling pathway
    Shigellosis


    ATG5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/452 Interacting proteins for ATG5 (Q9H1Y01, 3 ENSP000003433134) via UniProtKB, MINT, STRING, and/or I2D (see all 452)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TECPR1Q7Z6L11, 3, ENSP000004049234EBI-1047414,EBI-2946676 I2D: score=5 STRING: ENSP00000404923
    WDFY3Q8IZQ11, 3, ENSP000002958884EBI-1047414,EBI-1569256 I2D: score=3 STRING: ENSP00000295888
    MAP1LC3BQ9GZQ81, 3EBI-1047414,EBI-373144 I2D: score=3 
    GABARAPO951661, 3EBI-1047414,EBI-712001 I2D: score=1 
    ATG12O948173, ENSP000002744594I2D: score=8 STRING: ENSP00000274459
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ISS--
    GO:0001974blood vessel remodeling IEA--
    GO:0006914autophagy ISS--
    GO:0006915apoptotic process IEA--
    GO:0031397negative regulation of protein ubiquitination IEA--


    ATG5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATG5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATG5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATG5
    3 Novoseek chemical compound relationships for ATG5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-methyladenine 88.9 2 15657430 (1), 19115482 (1)
    wortmannin 35.4 1 19115482 (1)
    cycloheximide 24.7 1 7796880 (1)

    Search CenterWatch for drugs/clinical trials and news about ATG5 

    Transcripts
    for ATG5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATG5 gene: 
    NM_004849.2  

    Unigene Cluster for ATG5:

    Autophagy related 5
    Hs.486063  [show with all ESTs]
    Unigene Representative Sequence: Y11588
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369076(uc003prf.3 uc010kdb.3) ENST00000343245 ENST00000369070(uc003prg.3 uc010kdc.3)
    ENST00000475645 ENST00000476518 ENST00000360666

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATG5
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate ATG5 (see all 13):
    hsa-miR-30c hsa-miR-299-5p hsa-miR-3607-3p hsa-miR-216b hsa-miR-30d hsa-miR-4282 hsa-miR-3647-3p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: ATG5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG5 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG5
    Clone
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    Additional cDNA sequence: 

    AF293841.1 AK001899.1 AK299577.1 AK315800.1 BC002699.2 BC093011.1 BX537904.1 CR749386.1 
    EU283338.1 EU283339.1 Y11588.1 

    13 DOTS entries:

    DT.316534  DT.86852491  DT.100773368  DT.100773367  DT.100773370  DT.316536  DT.95184690  DT.102823419 
    DT.91844873  DT.100045110  DT.121325660  DT.40131866  DT.95259264 

    24/214 AceView cDNA sequences (see all 214):

    AI990740 AL541395 BM128085 BM542099 BM838049 BX537904 AI160403 AW519320 
    BU845830 AI377501 AI654046 CA429248 BQ049839 BX956342 BP357784 CB044559 
    BI764912 BU679973 BU622727 AI924047 BM852617 AA316000 AI420472 AI434826 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ATG5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
    SP1:                    -                                                               
    SP2:                                                                                    
    SP3:                                -                                                   
    SP4:                    -           -                                                   
    SP5:                    -           -     -     -                                       


    ECgene alternative splicing isoforms for ATG5

    Expression
    for ATG5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ATG5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATG5

    SOURCE GeneReport for Unigene cluster: Hs.486063

    UniProtKB/Swiss-Prot: ATG5_HUMAN, Q9H1Y0
    Tissue specificity: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the
    protein is dramatically highly expressed in apoptotic cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including ATG5: 
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              Cell Death PathwayFinder in human mouse rat

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    In Situ
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    Orthologs
    for ATG5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATG5 gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Atg51 , 5 autophagy-related 5 (yeast)5
    autophagy related 51    		 91.76(n)1
    96.73(a)1    		   10 (23.24 cM)5
    117931  NM_053069.51  NP_444299.11 
     442683585 
    chicken
    (Gallus gallus)    		 Aves ATG51 ATG5 autophagy related 5 homolog (S. cerevisiae) 84.73(n)
    89.82(a)    		   421784  NM_001006409.1  NP_001006409.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ATG56
    		 --
    		 90(a)
    		 1 ↔ 1
    		 1(189204532-189236511)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.237302 Xenopus laevis transcribed sequence with moderate similarity more 79.15(n)    BI477654.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.126862 Danio rerio clone RK112A2A05 APG5 autophagy 5-like more 74(n)    AY398310.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Atg51 Autophagy-specific gene 5 54.58(n)
    50(a)    		   31666  NM_132162.3  NP_572390.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea atg-51 Protein ATG-5 48.29(n)
    36.12(a)    		   171735  NM_058484.4  NP_490885.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons APG51 autophagy protein 5 47.17(n)
    35.09(a)    		   831594  NM_121735.4  NP_197231.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g01178001 hypothetical protein 44.83(n)
    35.06(a)    		   4328092  NM_001052225.1  NP_001045690.1 


    ENSEMBL Gene Tree for ATG5 (if available)
    TreeFam Gene Tree for ATG5 (if available) 

    Paralogs
    for ATG5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ATG5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2215 NCBI SNPs in ATG5 are shown (see all 2215)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs104845751,2
    		C,F,H,--106631860(+) AAATCC/TTGGTG 1 -- ds500133Minor allele frequency- T:0.14NS EA NA WA CSA 3080
    rs1917187251,2
    		--106631952(+) CAAAAA/GTATAA 1 -- ds50010--------
    rs579014431,2
    		C,--106631967(+) TTTTT-/TATCCT 1 -- ds50010--------
    rs782005521,2
    		C,--106631967(+) GTGGAT/CTTTTT 1 -- ds50014Minor allele frequency- C:0.18NA WA EA 360
    rs1511653281,2
    		--106631996(+) ATATTA/GCTATT 1 -- ds50010--------
    rs1390548231,2
    		--106631997(+) TATTGA/CTATTT 1 -- ds50010--------
    rs750160101,2
    		F,--106632045(+) TCCATG/TGTCAT 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1439742061,2
    		--106632195(+) TCAAAC/TAGGCA 1 -- ds50010--------
    rs1842682201,2
    		--106632260(+) TATTTC/TTCCAA 1 -- ds50010--------
    rs1887536661,2
    		--106632342(+) AGACGC/GACACA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ATG5 (106632351 - 106773695 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ATG5
         4 CNVs: 69581 64625 51781 99653
    Human Gene Mutation Database (HGMD): ATG5

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ATG5

    Disorders / Diseases
    for ATG5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATG5 for disorders           About GeneDecksing

    OMIM gene information: 604261    OMIM disorders: --

    20/28 diseases for ATG5 (see all 28):    About MalaCards
    inclusion body myositis    systemic lupus erythematosus    lupus erythematosus    acute myeloid leukemia
    myositis    myeloid leukemia    malignant glioma    squamous cell carcinoma
    shigellosis    myelodysplastic syndrome    rheumatoid arthritis    multiple sclerosis
    hepatitis c    huntington's disease    alzheimer's disease    arthritis
    colorectal cancer    leukemia    lung cancer    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for ATG5:
    Cancer

    2 Novoseek disease relationships for ATG5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 11.2 2 9596416 (1), 7796880 (1)
    necrosis 0 1 20431342 (1)

    Human Genome Epidemiology (HuGE) Navigator: ATG5 (8 documents)

    Export disorders for ATG5 gene to outside databases

    Publications
    for ATG5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATG5 gene, integrated from 9 sources (see all 90):
    (articles sorted by number of sources associating them with ATG5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast. (PubMed id 9563500)1, 2, 3, 9 Hammond E.M.... Grand R.J.A. (1998)
    2. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. (PubMed id 15778222)1, 3, 9 Pyo J.O....Jung Y.K. (2005)
    3. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. (PubMed id 9852036)1, 2, 9 Mizushima N.... Ohsumi Y. (1998)
    4. A novel protein expressed in mammalian cells undergoing apoptosis. (PubMed id 7796880)1, 2, 9 Grand R.J.A.... Gregory C.D. (1995)
    5. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. (PubMed id 22342342)1, 2 Chen D.... Zhong Q. (2012)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. (PubMed id 11266458)1, 2 Mizushima N.... Yoshimori T. (2001)
    9. Pot1, the putative telomere end-binding protein in fission yeast and humans. (PubMed id 11349150)1, 3 Baumann P. and Cech T.R. (2001)
    10. The Rac1/MKK7/JNK pathway signals upregulation of Atg 5 and subsequent autophagic cell death in response to oncogenic Ras. (PubMed id 19783847)1, 9 Byun J.Y....Lee S.J. (2009)

    External Searches for ATG5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ATG5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9474 HGNC: 589 AceView: APG5L Ensembl:ENSG00000057663 euGenes: HUgn9474
    ECgene: ATG5 Kegg: 9474 H-InvDB: ATG5

    Other Databases showing ATG5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATG5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATG5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATG5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATG5 gene:
    Search GeneIP for patents involving ATG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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