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ATG4D Gene

protein-coding   GIFtS: 53
GCID: GC19P010654

Autophagy Related 4D, Cysteine Peptidase

(Previous names: AUT-like 4, cysteine endopeptidase (S. cerevisiae), APG4...)
(Previous symbols: AUTL4, APG4D)
  Search for ATG4D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Autophagy Related 4D, Cysteine Peptidase1 2     APG4-D2
APG4D1 2 3 5     APG4 Autophagy 4 Homolog D2
AUTL41 2 3 5     ATG4 Autophagy Related 4 Homolog D2
Autophagy-Related Cysteine Endopeptidase 42 3     autophagin-42
Autophagy-Related Protein 4 Homolog D2 3     Cysteine Protease ATG4D2
AUT-Like 4 Cysteine Endopeptidase2 3     Cysteine Protease Involved In Autophagy2
APG4 Autophagy 4 Homolog D (S. Cerevisiae)1     Autophagin-43
ATG4 Autophagy Related 4 Homolog D (S. Cerevisiae)1     EC 3.4.22.-3
AUT-Like 4, Cysteine Endopeptidase (S. Cerevisiae)1     EC 3.4.228

External Ids:    HGNC: 207891   Entrez Gene: 849712   Ensembl: ENSG000001307347   OMIM: 6113405   UniProtKB: Q86TL03   

Export aliases for ATG4D gene to outside databases

Previous GC identifers: GC19P010518 GC19P010232


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATG4D Gene:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.
Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation,
metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some
malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been
proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of
this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and
organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jul 2013)

GeneCards Summary for ATG4D Gene:
ATG4D (autophagy related 4D, cysteine peptidase) is a protein-coding gene. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is ATG4C.

UniProtKB/Swiss-Prot: ATG4D_HUMAN, Q86TL0
Function: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and
autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a
C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to
phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity
of delipidating enzyme for the PE-conjugated forms
Function: Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial
dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play
important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ATG4D gene promoter:
         HOXA5   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG4D promoter sequence
   Search Chromatin IP Primers for ATG4D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATG4D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ATG4D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG4D gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010654:  view genomic region     (about GC identifiers)

Start:
10,654,571 bp from pter      End:
10,664,094 bp from pter
Size:
9,524 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATG4D_HUMAN, Q86TL0 (See protein sequence)
Recommended Name: Cysteine protease ATG4D  
Size: 474 amino acids; 52922 Da

Explore the universe of human proteins at neXtProt for ATG4D: NX_Q86TL0

Explore proteomics data for ATG4D at MOPED

Post-translational modifications: 

  • Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic
    mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to
    mitochondroal import of the protein1
  • Ubiquitination2 at Lys281, Lys298, Lys322
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ATG4D (Q86TL0) (see all 9)
     KMDPSCT  AGDWYGP  FPLESFHC  WLTYRRDFP 


    See ATG4D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001268433.1  NP_116274.3  

    ENSEMBL proteins: 
     ENSP00000467906   ENSP00000468290   ENSP00000465716   ENSP00000311318   ENSP00000467407  
     ENSP00000467223   ENSP00000465089   ENSP00000466439   ENSP00000468780   ENSP00000466759  
     ENSP00000467694   ENSP00000441375  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005078 Peptidase_C54

    Graphical View of Domain Structure for InterPro Entry Q86TL0

    ProtoNet protein and cluster: Q86TL0

    UniProtKB/Swiss-Prot: ATG4D_HUMAN, Q86TL0
    Domain: Residues 64 to 103 constitute a cryptic mitochondrial transit peptide which is revealed after cleavage by
    caspase of residues 1 to 63 upon oxidative stress and cell death. It acts then as a functional transit peptide,
    and allows the import of the cleaved protein into the mitochondria (PubMed:22441018)
    Similarity: Belongs to the peptidase C54 family


    Find genes that share domains with ATG4D           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATG4D_HUMAN, Q86TL0
    Function: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and
    autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a
    C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to
    phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity
    of delipidating enzyme for the PE-conjugated forms
    Function: Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial
    dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play
    important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability
    Enzyme regulation: Inhibited by N-ethylmaleimide
    Biophysicochemical properties: Kinetic parameters: KM=13.1 uM for MAP1LC3B; KM=7.2 uM for GABARAPL2;

         Enzyme Numbers (IUBMB): EC 3.4.222 EC 3.4.22.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity ISS12446702
    GO:0008234cysteine-type peptidase activity ----
         
    Find genes that share ontologies with ATG4D           About GenesLikeMe


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidATG4D 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATG4D_HUMAN, Q86TL0: Cysteine protease ATG4D: Cytoplasm
    ATG4D_HUMAN, Q86TL0: Cysteine protease ATG4D, mitochondrial: Cytoplasm. Mitochondrion matrix. Note=Imported into
    mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    vacuole2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS12446702
    GO:0005759mitochondrial matrix IEA--

    Find genes that share ontologies with ATG4D           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATG4D About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of autophagy
    Regulation of autophagy


    Find genes that share SuperPaths with ATG4D           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for ATG4D):
        Regulation of autophagy

        Pathway & Disease-focused RT2 Profiler PCR Array including ATG4D: 
              Autophagy in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATG4D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ATG4D (Q86TL03 ENSP000003113184) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPO951663, ENSP000003068664I2D: score=1 STRING: ENSP00000306866
    TAF12Q165143I2D: score=5 
    CASP3P425743I2D: score=1 
    CASP8Q147903I2D: score=1 
    GABARAPL2ENSP000000372434STRING: ENSP00000037243
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006914autophagy IEA--
    GO:0006915apoptotic process IEA--
    GO:0015031protein transport IEA--

    Find genes that share ontologies with ATG4D           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATG4D



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATG4D gene (2 alternative transcripts): 
    NM_001281504.1  NM_032885.5  

    Unigene Cluster for ATG4D:

    Autophagy related 4D, cysteine peptidase
    Hs.512799  [show with all ESTs]
    Unigene Representative Sequence: BC068992
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586417 ENST00000590096 ENST00000588857 ENST00000585752 ENST00000309469(uc010xlg.2 uc002mov.3 uc010xlh.2 uc010dxh.3 uc010dxi.3 uc010dxj.3)
    ENST00000588667 ENST00000586477 ENST00000586863 ENST00000589753 ENST00000587256
    ENST00000588972 ENST00000585437 ENST00000540862
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ATG4D (see all 21):
    hsa-miR-125a-5p hsa-miR-148b hsa-miR-301a hsa-miR-125b hsa-miR-199b-5p hsa-miR-3121-3p hsa-miR-130b hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidATG4D 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ATG4D
      QuantiFast Probe-based Assays in human, mouse, rat ATG4D

    Additional mRNA sequence: 

    AJ312332.1 AK056210.1 AK223383.1 AK294676.1 AK314712.1 AK316454.1 BC007639.1 BC016845.1 
    BC068992.1 

    10 DOTS entries:

    DT.445212  DT.121643657  DT.121504211  DT.91700205  DT.100775345  DT.95167995  DT.121504204  DT.97858898 
    DT.100038930  DT.91700605 

    Selected AceView cDNA sequences (see all 127):

    BQ880521 AI971639 BU553580 BM710114 BU728461 NM_032885 BQ691009 CB851811 
    BQ685568 BQ687308 AJ312332 BF475364 CF140182 BQ897613 CB161138 BC016845 
    AW246095 BC068992 F30370 BU157350 AW170307 BQ674330 AW024569 BQ879986 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATG4D (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                                                                                                                      
    SP2:                          -                                                           -     -                                                         
    SP3:                                                                                                                                                      
    SP4:                          -                                                     -     -     -                                                         
    SP5:                                                                                -     -     -                                                         


    ECgene alternative splicing isoforms for ATG4D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATG4D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGGTGTGG
    ATG4D Expression
    About this image

    ATG4D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATG4D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512799

    UniProtKB/Swiss-Prot: ATG4D_HUMAN, Q86TL0
    Tissue specificity: Mainly expressed in skeletal muscle and, to a lower extent, in testis

        Pathway & Disease-focused RT2 Profiler PCR Array including ATG4D: 
              Autophagy in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG4D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ATG4D gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg4d1 , 5 autophagy-related 4D (yeast)5
    autophagy related 4D, cysteine peptidase1
    83.33(n)1
    85.44(a)1
      9 (7.75 cM)5
    2350401  NM_153583.101  NP_705811.81 
     212652995 
    lizard
    (Anolis carolinensis)
    Reptilia ATG4D6
    autophagy related 4D, cysteine peptidase
    57(a)
    1 ↔ 1
    2(80345124-80362833)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atg4d1 autophagy related 4D, cysteine peptidase 59.93(n)
    57.14(a)
      734111  NM_001045781.2  NP_001039246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atg4da6
    atg4db6
    autophagy related 4D, cysteine peptidase b
    51(a)
    41(a)
    many → 1
    many → 1
    1(51895489-51915529) ENSDARG00000043548
    3(7277681-7294248) ENSDARG00000088145
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61941 CG6194 53.43(n)
    49.12(a)
      41868  NM_142195.2  NP_650452.1 
    worm
    (Caenorhabditis elegans)
    Secernentea atg-4.21 atg-4.2 46.18(n)
    38.53(a)
      3565022  NM_069807.3  NP_502208.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG46
    Conserved cysteine protease required for autophagy...
    21(a)
    1 → many
    XIV(227370-228854) YNL223W


    ENSEMBL Gene Tree for ATG4D (if available)
    TreeFam Gene Tree for ATG4D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ATG4D gene
    ATG4C2  ATG4A2  ATG4B2  
    4 SIMAP similar genes for ATG4D using alignment to 12 protein entries:     ATG4D_HUMAN (see all proteins):
    ATG4C    DKFZp686G0859    ATG4A    ATG4B

    Find genes that share paralogs with ATG4D           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATG4D (see all 198)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1490560091,2
    C--10652718(+) AAGAGC/TGAAAC 1 -- us2k10--------
    rs1831318251,2
    --10652925(+) CCAGGA/GGTGGC 1 -- us2k10--------
    rs1431025541,2
    --10652934(+) GCCAGA/GCACGG 1 -- us2k10--------
    rs1881048691,2
    --10652947(+) GCCCAA/CGCCTG 1 -- us2k10--------
    rs124595441,2
    C,F,H--10653018(+) tcctgG/Actaac 1 -- us2k15Minor allele frequency- A:0.42NA CSA 12
    rs124595471,2
    C,F,H--10653070(+) caggcA/C/Gtggtg 1 -- us2k14NA 8
    rs1462648291,2
    C--10653123(+) AGAATA/GGTGTG 1 -- us2k10--------
    rs1381327351,2
    --10653180(+) CTCCAA/GCCTGG 1 -- us2k10--------
    rs1114282491,2
    C,F--10653204(+) ACTCCG/ATCTCA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs340755361,2
    C--10653209(+) GTCTC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for ATG4D (10654571 - 10664094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ATG4D:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911045CNV Loss21882294
    nsv833744CNV Loss17160897
    nsv911046CNV Loss21882294
    nsv911042CNV Loss21882294
    nsv833745CNV Loss17160897
    dgv3727n71CNV Loss21882294
    dgv3725n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATG4D
    DNA2.0 Custom Variant and Variant Library Synthesis for ATG4D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611340    OMIM disorders: --


    Find genes that share disorders with ATG4D           About GenesLikeMe


    Export disorders for ATG4D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATG4D gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ATG4D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. (PubMed id 12446702)1, 2, 3 Marino G....Lopez-Otin C. (J. Biol. Chem. 2003)
    2. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. (PubMed id 19549685)1, 2, 9 Betin V.M. and Lane J.D. (J. Cell. Sci. 2009)
    3. A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress. (PubMed id 22441018)1, 2 Betin V.M....Lane J.D. (Autophagy 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation. (PubMed id 23508006)1 Betin V.M....Lane J.D. (Autophagy 2013)
    6. Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates. (PubMed id 21177865)2 Li M....Yin X.M. (J. Biol. Chem. 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84971 HGNC: 20789 AceView: APG4D Ensembl:ENSG00000130734 euGenes: HUgn84971
    ECgene: ATG4D Kegg: 84971 H-InvDB: ATG4D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATG4D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATG4D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATG4D gene:
    Search GeneIP for patents involving ATG4D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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