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Aliases for ATG4C Gene

Aliases for ATG4C Gene

  • Autophagy Related 4C Cysteine Peptidase 2 3
  • Autophagy Related 4C, Cysteine Peptidase 2 3 5
  • Autophagy-Related Cysteine Endopeptidase 3 3 4
  • Autophagy-Related Protein 4 Homolog C 3 4
  • AUT-Like 3 Cysteine Endopeptidase 3 4
  • Autophagin-3 3 4
  • AUTL1 3 4
  • APG4C 3 4
  • AUTL3 3 4
  • AUT (S. Cerevisiae)-Like 1, Cysteine Endopeptidase; AUT-Like 1, Cysteine Endopeptidase (S. Cerevisiae) 2
  • ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae) 2
  • APG4 Autophagy 4 Homolog C (S. Cerevisiae) 2
  • ATG4 Autophagy Related 4 Homolog C 3
  • AUT-Like 1, Cysteine Endopeptidase 3
  • APG4 Autophagy 4 Homolog C 3
  • EC 3.4.22.- 4
  • EC 3.4.22 63
  • APG4-C 3

External Ids for ATG4C Gene

Previous HGNC Symbols for ATG4C Gene

  • AUTL1
  • APG4C

Previous GeneCards Identifiers for ATG4C Gene

  • GC01P062962
  • GC01P063249
  • GC01P061361

Summaries for ATG4C Gene

Entrez Gene Summary for ATG4C Gene

  • Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ATG4C Gene

ATG4C (Autophagy Related 4C Cysteine Peptidase) is a Protein Coding gene. Diseases associated with ATG4C include Dependent Personality Disorder. Among its related pathways are p53 Pathway (RnD) and Cellular Senescence. GO annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is ATG4B.

UniProtKB/Swiss-Prot for ATG4C Gene

  • Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG4C Gene

Genomics for ATG4C Gene

Regulatory Elements for ATG4C Gene

Enhancers for ATG4C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATG4C on UCSC Golden Path with GeneCards custom track

Promoters for ATG4C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATG4C on UCSC Golden Path with GeneCards custom track

Genomic Location for ATG4C Gene

Chromosome:
1
Start:
62,784,106 bp from pter
End:
62,865,513 bp from pter
Size:
81,408 bases
Orientation:
Plus strand

Genomic View for ATG4C Gene

Genes around ATG4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG4C Gene

Proteins for ATG4C Gene

  • Protein details for ATG4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DT6-ATG4C_HUMAN
    Recommended name:
    Cysteine protease ATG4C
    Protein Accession:
    Q96DT6
    Secondary Accessions:
    • A6NLR8
    • D3DQ58
    • Q96K04

    Protein attributes for ATG4C Gene

    Size:
    458 amino acids
    Molecular mass:
    52497 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55356.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305};

neXtProt entry for ATG4C Gene

Proteomics data for ATG4C Gene at MOPED

Selected DME Specific Peptides for ATG4C Gene

Post-translational modifications for ATG4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG4C Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ATG4C (ATG4C)

Domains & Families for ATG4C Gene

Gene Families for ATG4C Gene

Protein Domains for ATG4C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG4C Gene

Graphical View of Domain Structure for InterPro Entry

Q96DT6

UniProtKB/Swiss-Prot:

ATG4C_HUMAN :
  • Belongs to the peptidase C54 family.
Family:
  • Belongs to the peptidase C54 family.
genes like me logo Genes that share domains with ATG4C: view

Function for ATG4C Gene

Molecular function for ATG4C Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=47.5 uM for MAP1LC3B {ECO:0000269 PubMed:21177865}; KM=12.4 uM for GABARAPL2 {ECO:0000269 PubMed:21177865};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide.
UniProtKB/Swiss-Prot Function:
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Enzyme Numbers (IUBMB) for ATG4C Gene

genes like me logo Genes that share phenotypes with ATG4C: view

Animal Models for ATG4C Gene

MGI Knock Outs for ATG4C:

Animal Model Products

  • Taconic Biosciences Mouse Models for ATG4C

miRNA for ATG4C Gene

miRTarBase miRNAs that target ATG4C

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ATG4C Gene

Localization for ATG4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG4C Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG4C Gene COMPARTMENTS Subcellular localization image for ATG4C gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ATG4C Gene

Pathways & Interactions for ATG4C Gene

genes like me logo Genes that share pathways with ATG4C: view

Pathways by source for ATG4C Gene

1 GeneTex pathway for ATG4C Gene
2 Reactome pathways for ATG4C Gene
1 KEGG pathway for ATG4C Gene
1 R&D Systems pathway for ATG4C Gene

Gene Ontology (GO) - Biological Process for ATG4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IBA --
GO:0006508 proteolysis IEA,IDA 12446702
GO:0006914 autophagy IEA,IGI 12446702
GO:0016485 protein processing IBA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with ATG4C: view

No data available for SIGNOR curated interactions for ATG4C Gene

Drugs & Compounds for ATG4C Gene

(7) Drugs for ATG4C Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nimodipine Approved Pharma Potentiation, Activator 21
Omeprazole Approved, Investigational Pharma Activator H+,K+-ATPase inhibitor 327
Chloroquine diphosphate Pharma Antimalarial drug 142
Dexamethasone (DHAP) Pharma Glucocorticoidan;ti-inflammatory 0
Sulfacetamide Sodium Pharma Sulfonamide antibiotic 0

(7) ApexBio Compounds for ATG4C Gene

Compound Action Cas Number
Chloroquine diphosphate Antimalarial drug 50-63-5
Dexamethasone (DHAP) Glucocorticoidan;ti-inflammatory 1950-02-2
Divalproex Sodium Epilepsy/migraines/bipolar disorder medicine 76584-70-8
Nimodipine 66085-59-4
Omeprazole H+,K+-ATPase inhibitor 73590-58-6
Sulfacetamide Sodium Sulfonamide antibiotic 127-56-0
Trifluoperazine 2HCl 440-17-5
genes like me logo Genes that share compounds with ATG4C: view

Transcripts for ATG4C Gene

Unigene Clusters for ATG4C Gene

Autophagy related 4C, cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATG4C Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - -
SP7: - -
SP8: -
SP9: - -

Relevant External Links for ATG4C Gene

GeneLoc Exon Structure for
ATG4C
ECgene alternative splicing isoforms for
ATG4C

Expression for ATG4C Gene

mRNA expression in normal human tissues for ATG4C Gene

Protein differential expression in normal tissues from HIPED for ATG4C Gene

This gene is overexpressed in Frontal cortex (22.5), Heart (19.4), and Peripheral blood mononuclear cells (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG4C Gene



SOURCE GeneReport for Unigene cluster for ATG4C Gene Hs.7353

mRNA Expression by UniProt/SwissProt for ATG4C Gene

Q96DT6-ATG4C_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, heart, liver and testis.
genes like me logo Genes that share expression patterns with ATG4C: view

Protein tissue co-expression partners for ATG4C Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ATG4C Gene

Orthologs for ATG4C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG4C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATG4C 35
  • 93.52 (n)
  • 94.32 (a)
ATG4C 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG4C 35
  • 94.1 (n)
  • 94.54 (a)
ATG4C 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg4c 35
  • 87.92 (n)
  • 90.39 (a)
Atg4c 16
Atg4c 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATG4C 35
  • 100 (n)
  • 100 (a)
ATG4C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg4c 35
  • 85.88 (n)
  • 89.52 (a)
oppossum
(Monodelphis domestica)
Mammalia ATG4C 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG4C 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG4C 35
  • 80.35 (n)
  • 82.53 (a)
ATG4C 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG4C 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg4c 35
  • 73.07 (n)
  • 71.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1688 35
zebrafish
(Danio rerio)
Actinopterygii atg4c 35
  • 64.75 (n)
  • 60.84 (a)
atg4c 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6194 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-4.2 36
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG4 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.753 36
  • 29 (a)
OneToMany
Species with no ortholog for ATG4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG4C Gene

ENSEMBL:
Gene Tree for ATG4C (if available)
TreeFam:
Gene Tree for ATG4C (if available)

Paralogs for ATG4C Gene

Paralogs for ATG4C Gene

(1) SIMAP similar genes for ATG4C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ATG4C: view

Variants for ATG4C Gene

Sequence variations from dbSNP and Humsavar for ATG4C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs943696 -- 62,806,467(+) TATTT(A/G)TGATT intron-variant
rs1333733 -- 62,856,890(+) ACAGT(A/G)AAACC intron-variant
rs1333735 -- 62,861,628(+) ACACA(C/G)AGAGA intron-variant
rs1333736 -- 62,861,764(+) ATATC(A/T)TTTTT intron-variant
rs1360677 -- 62,863,273(+) GAAGG(C/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG4C Gene

Variant ID Type Subtype PubMed ID
nsv830015 CNV Gain 17160897

Variation tolerance for ATG4C Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ATG4C Gene

Disorders for ATG4C Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATG4C Gene - From: DISEASES

Disorder Aliases PubMed IDs
dependent personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search ATG4C in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATG4C

Genetic Association Database (GAD)
ATG4C
Human Genome Epidemiology (HuGE) Navigator
ATG4C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG4C
genes like me logo Genes that share disorders with ATG4C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATG4C Gene

Publications for ATG4C Gene

  1. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. (PMID: 12446702) Marino G. … Lopez-Otin C. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3
  3. HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy. (PMID: 25490467) Borel S. … Biard-Piechaczyk M. (AIDS 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. (PMID: 22248718) Korkmaz G. … Gozuacik D. (Autophagy 2012) 3

Products for ATG4C Gene

Sources for ATG4C Gene

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