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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATG4C Gene

protein-coding   GIFtS: 59
GCID: GC01P063249

Autophagy Related 4C, Cysteine Peptidase

(Previous names: AUT (S. cerevisiae)-like 1, cysteine endopeptidase; AUT-like...)
(Previous symbols: AUTL1, APG4C)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Autophagy Related 4C, Cysteine Peptidase1 2     APG4-C2
APG4C1 2 3     APG4 Autophagy 4 Homolog C2
AUTL11 2 3     ATG4 Autophagy Related 4 Homolog C2
Autophagy-Related Cysteine Endopeptidase 32 3     AUT-Like 1, Cysteine Endopeptidase2
Autophagy-Related Protein 4 Homolog C2 3     autophagin-32
AUTL32 3     Cysteine Protease ATG4C2
AUT-Like 3 Cysteine Endopeptidase2 3     Autophagin-33
APG4 Autophagy 4 Homolog C (S. Cerevisiae)1     EC 3.4.22.-3
ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae)1     EC 3.4.228
AUT (S. Cerevisiae)-Like 1, Cysteine Endopeptidase; AUT-Like 1, Cysteine
Endopeptidase (S. Cerevisiae)1
     

External Ids:    HGNC: 160401   Entrez Gene: 849382   Ensembl: ENSG000001257037   OMIM: 6113395   UniProtKB: Q96DT63   

Export aliases for ATG4C gene to outside databases

Previous GC identifers: GC01P062962 GC01P061361


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATG4C Gene:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.
Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation,
metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some
malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been
proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as
a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same
protein, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ATG4C Gene: 
ATG4C (autophagy related 4C, cysteine peptidase) is a protein-coding gene. Diseases associated with ATG4C include dependent personality disorder, and specific phobia. GO annotations related to this gene include cysteine-type endopeptidase activity and peptidase activity. An important paralog of this gene is ATG4A.

UniProtKB/Swiss-Prot: ATG4C_HUMAN, Q96DT6
Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2
or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller
form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine
(PE)-conjugated form, and has the capacity for the binding to autophagosomes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ATG4C
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG4C promoter sequence
   Search SABiosciences Chromatin IP Primers for ATG4C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3

ATG4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG4C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P063249:  view genomic region     (about GC identifiers)

Start:
63,249,777 bp from pter      End:
63,331,184 bp from pter
Size:
81,408 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATG4C_HUMAN, Q96DT6 (See protein sequence)
Recommended Name: Cysteine protease ATG4C  
Size: 458 amino acids; 52497 Da
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=BAB55356.1; Type=Frameshift; Positions=420;
Secondary accessions: A6NLR8 D3DQ58 Q96K04

Explore the universe of human proteins at neXtProt for ATG4C: NX_Q96DT6

Explore proteomics data for ATG4C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96DT6

  • 4/7 DME Specific Peptides for ATG4C (Q96DT6) (see all 7)
     KMDPSCT  AGDWYGP  GIIGGKPK  SLIYMDPH 

    ATG4C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATG4C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_116241.2  NP_835739.1  

    ENSEMBL proteins: 
     ENSP00000396614   ENSP00000322159   ENSP00000360161   ENSP00000360159   ENSP00000391820  

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    Cloud-Clone Corp. Proteins for ATG4C 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA12446702
    GO:0005737cytoplasm ISS12446702
    GO:0005829cytosol ISS12446702

    ATG4C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005078 Peptidase_C54

    Graphical View of Domain Structure for InterPro Entry Q96DT6

    ProtoNet protein and cluster: Q96DT6

    UniProtKB/Swiss-Prot: ATG4C_HUMAN, Q96DT6
    Similarity: Belongs to the peptidase C54 family


    ATG4C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATG4C_HUMAN, Q96DT6
    Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2
    or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller
    form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine
    (PE)-conjugated form, and has the capacity for the binding to autophagosomes
    Enzyme regulation: Inhibited by N-ethylmaleimide

         Enzyme Numbers (IUBMB): EC 3.4.222 EC 3.4.22.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IMP12446702
    GO:0008233peptidase activity IDA12446702
    GO:0008234cysteine-type peptidase activity ----
         
    ATG4C for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atg4c):
     behavior/neurological  cellular  homeostasis/metabolism  tumorigenesis 

    ATG4C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Atg4ctm1Otin for ATG4C

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ATG4C 
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    SwitchGear 3'UTR luciferase reporter plasmidATG4C 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATG4C About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of autophagy
    Regulation of autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for ATG4C):
        Regulation of autophagy


    ATG4C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG4C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/363 Interacting proteins for ATG4C (Q96DT63 ENSP000003221594) via UniProtKB, MINT, STRING, and/or I2D (see all 363)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IGI12446702
    GO:0006508proteolysis IDA12446702
    GO:0006612protein targeting to membrane ISS12446702
    GO:0006914autophagy IGI12446702
    GO:0015031protein transport ----

    ATG4C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATG4C

    Search CenterWatch for drugs/clinical trials and news about ATG4C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ATG4C gene (2 alternative transcripts): 
    NM_032852.3  NM_178221.2  

    Unigene Cluster for ATG4C:

    Autophagy related 4C, cysteine peptidase
    Hs.7353  [show with all ESTs]
    Unigene Representative Sequence: NM_032852
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000443289 ENST00000317868(uc001dau.3) ENST00000371120(uc001dat.3)
    ENST00000371118 ENST00000414558

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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ATG4C (see all 9):
    hsa-miR-3163 hsa-miR-495 hsa-miR-607 hsa-miR-323b-3p hsa-miR-548aa hsa-miR-340 hsa-miR-1279 hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidATG4C 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AJ312234.1 AJ320169.1 AK027773.1 BC008395.1 BC018678.1 BC033024.1 

    4 DOTS entries:

    DT.95097338  DT.100787855  DT.207609  DT.91826607 

    24/137 AceView cDNA sequences (see all 137):

    BM984989 AA465602 BX351567 BM141891 BU658296 NM_032852 AI312778 BI518482 
    BQ787961 BG215284 BE463621 AJ312234 BM720875 BQ018078 AI214467 AA465245 
    BU754331 CK819954 BM273268 CB148165 NM_178221 CR599981 BX378616 BU753091 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ATG4C (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                      -     -     -                                                                                             
    SP2:                                -     -     -     -                                                                                             
    SP3:                                      -     -     -     -                                                                                       
    SP4:                                      -     -     -                                                                                             
    SP5:        -     -     -     -     -     -     -     -                                                                                             


    ECgene alternative splicing isoforms for ATG4C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATG4C expression in normal human tissues (normalized intensities)      ATG4C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCTCATT
    ATG4C Expression
    About this image


    ATG4C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Septum   
     
     Blood (Muscoskeletal System)    fully expand to see all 2 entries
             monocyte-derived macrophage   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Bone (Muscoskeletal System)
             BONE MARROW   

    See ATG4C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATG4C

    SOURCE GeneReport for Unigene cluster: Hs.7353

    UniProtKB/Swiss-Prot: ATG4C_HUMAN, Q96DT6
    Tissue specificity: Highly expressed in skeletal muscle, heart, liver and testis

        SABiosciences Expression via Pathway-Focused PCR Array including ATG4C: 
              Autophagy in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG4C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ATG4C gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg4c1 , 5 autophagy-related 4C (yeast)5
    autophagy related 4C, cysteine peptidase1
    87.92(n)1
    90.39(a)1
      4 (45.61 cM)5
    2425571  NM_175029.31  NP_778194.31 
     991939345 
    chicken
    (Gallus gallus)
    Aves ATG4C1 ATG4 autophagy related 4 homolog C (S. cerevisiae) 80.35(n)
    82.53(a)
      424688  XM_422520.3  XP_422520.2 
    lizard
    (Anolis carolinensis)
    Reptilia ATG4C6
    Uncharacterized protein
    76(a)
    1 ↔ 1
    4(99736650-99765867)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16882 Xenopus laevis transcribed sequence with weak similarity more 77.9(n)    CA973254.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atg4c1 autophagy-related 4C (yeast) 65.04(n)
    60.62(a)
      415193  NM_001002103.1  NP_001002103.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61946
    --
    27(a)
    1 → many
    3R(11179433-11182641)
    worm
    (Caenorhabditis elegans)
    Secernentea atg-4.26
    Protein ATG-4.2
    21(a)
    possible ortholog
    IV(11668028-11671502)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG46
    Conserved cysteine protease required for autophagy...
    20(a)
    1 → many
    XIV(227370-228854)


    ENSEMBL Gene Tree for ATG4C (if available)
    TreeFam Gene Tree for ATG4C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATG4C gene
    ATG4A2  ATG4D2  ATG4B2  
    1 SIMAP similar gene for ATG4C using alignment to 5 protein entries:     ATG4C_HUMAN (see all proteins):
    ATG4D

    ATG4C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1511 SNPs in ATG4C are shown (see all 1511)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507341961,2
    --63247878(+) CTTTTA/GTATAT 2 -- us2k10--------
    rs1392013201,2
    --63247951(+) AAAATA/GCATGC 2 -- us2k10--------
    rs1872321091,2
    --63248030(+) TCTCTC/TCTAAA 2 -- us2k10--------
    rs171238301,2
    C,F,H--63248080(+) CCACAA/GGCTAT 2 -- us2k115Minor allele frequency- G:0.21NA NS EA WA CSA 927
    rs1912646661,2
    --63248125(+) ATAAGC/TGTGCC 2 -- us2k10--------
    rs1837767981,2
    --63248210(+) AGATCC/TAGCTA 2 -- us2k10--------
    rs114204321,2
    C--63248232(+) AAAAA-/ATTTAA 2 -- us2k1 tfbs30--------
    rs1439734971,2
    --63248343(+) TTTCAC/TAGTCC 2 -- us2k10--------
    rs66583641,2
    C,F,H--63248349(+) AGTCCG/CGTGGC 2 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs173881701,2
    C,F,H--63248396(+) TTTCCT/CATGTA 2 -- us2k121Minor allele frequency- C:0.14NA NS EA WA CSA 2365

    HapMap Linkage Disequilibrium report for ATG4C (63249777 - 63331184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ATG4C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830015CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611339    OMIM disorders: --

    4 diseases for ATG4C:    About MalaCards
    dependent personality disorder    specific phobia    personality disorder    parkinson's disease

    3 diseases from the University of Copenhagen DISEASES database for ATG4C:
    Autistic disorder     Dependent personality disorder     Parkinson's disease

    ATG4C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ATG4C
    Human Genome Epidemiology (HuGE) Navigator: ATG4C (1 document)

    Export disorders for ATG4C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATG4C gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ATG4C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. (PubMed id 12446702)1, 2, 3, 9 Marino G....Lopez-Otin C. (2003)
    2. Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1, 4 Croteau-Chonka D.C....Mohlke K.L. (2010)
    3. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. (PubMed id 18193044)1, 4 Kathiresan S....Orho-Melander M. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. miR-376b controls starvation and mTOR inhibition-relat ed autophagy by targeting ATG4C and BECN1. (PubMed id 22248718)1 Korkmaz G....Gozuacik D. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84938 HGNC: 16040 AceView: APG4C Ensembl:ENSG00000125703 euGenes: HUgn84938
    ECgene: ATG4C Kegg: 84938 H-InvDB: ATG4C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATG4C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATG4C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATG4C gene:
    Search GeneIP for patents involving ATG4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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