ATG4B Gene
protein-coding GIFtS: 60
GCID: GC02P242578
|
|
autophagy related 4B, cysteine peptidase(Previous names: APG4 autophagy 4 homolog B (S. cerevisiae), ATG4 autophagy...)
(Previous symbol: APG4B)
| |
Aliases
for ATG4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Autophagy Related 4B, Cysteine Peptidase1 2 | | APG4 Autophagy 4 Homolog B (S. Cerevisiae)1 | | APG4B1 2 3 | | ATG4 Autophagy Related 4 Homolog B (S. Cerevisiae)1 | | AUTL11 2 3 | | APG4 Autophagy 4 Homolog B2 | | KIAA09431 3 | | ATG4 Autophagy Related 4 Homolog B2 | | Autophagy-Related Cysteine Endopeptidase 12 3 | | Autophagin-13 | | Autophagy-Related Protein 4 Homolog B2 3 | | Cysteine Protease ATG4B2 | | AUT-Like 1 Cysteine Endopeptidase2 3 | | Autophagin-13 | | HAPG4B1 | | EC 3.4.22.-3 | | Apg4B1 | | EC 3.4.228 | | DKFZp586D18221 | | |
Export aliases for ATG4B gene to outside databasesPrevious GC identifers: GC02P242297 GC02P242225 GC02P234345 |
Summaries
for ATG4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ATG4B:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagyis postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis,non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and arole for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes amember of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family ofcysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ATG4B_HUMAN, Q9Y4P1Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of MAP1LC3, GABARAPL1, GABARAPL2and GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form(form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine(PE)-conjugated form, and has the capacity for the binding to autophagosomes. Also mediates the lipid deconjugationrequired for target recycling
Gene Wiki entry for ATG4B
|
Genomic Views
for ATG4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005416.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATG4B gene promoter:
Pax-6 YY1 GATA-1 RORalpha1 MEF-2A SRY E2F-1 E2F HOXA5 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATG4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3ATG4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P242578: view genomic region
(about GC identifiers)
Start:
|
242,576,628 bp from pter |
End:
|
242,613,272 bp from pter |
Size:
|
36,645 bases |
Orientation:
|
plus strand |
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Proteins
for ATG4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATG4B_HUMAN, Q9Y4P1 (See
protein sequence)Recommended Name: Cysteine protease ATG4B Size: 393 amino acids; 44294 Da
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=BAA76787.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAC86110.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
5 PDB 3D structures from  and Proteopedia  for ATG4B:2CY7 (3D)
2D1I (3D)
2Z0D (3D)
2Z0E (3D)
2ZZP (3D)
Secondary accessions: B7WNK2 Q53NU4 Q6ZUV8 Q8WYM9 Q96K07 Q96K96 Q96SZ1 Q9Y2F2Alternative splicing: 5 isoforms: Q9Y4P1-1 Q9Y4P1-2 Q9Y4P1-3 Q9Y4P1-4 Q9Y4P1-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ATG4B: NX_Q9Y4P1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4P1
4/9 DME Specific Peptides for ATG4B (Q9Y4P1) (see all 9)
ATG4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_037457.3 NP_847896.1
ENSEMBL proteins: ENSP00000383964 ENSP00000384661 ENSP00000384259 ENSP00000383583 ENSP00000400050 ENSP00000409895 ENSP00000390597 ENSP00000383582 ENSP00000407389 ENSP00000344960 ENSP00000410526 ENSP00000404783 ENSP00000442378 ENSP00000379692
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ATG4B for ontologies About GeneDecksing
ATG4B Antibody Products:
Assay Products for ATG4B: |
Protein
Domains /
Families
for ATG4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATG4B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y4P1ProtoNet protein and cluster: Q9Y4P1 UniProtKB/Swiss-Prot: ATG4B_HUMAN, Q9Y4P1Similarity: Belongs to the peptidase C54 family |
Function
for ATG4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ATG4B_HUMAN, Q9Y4P1Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of MAP1LC3, GABARAPL1, GABARAPL2and GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form(form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine(PE)-conjugated form, and has the capacity for the binding to autophagosomes. Also mediates the lipid deconjugationrequired for target recyclingEnzyme regulation: Inhibited by N-ethylmaleimideEnzyme Numbers (IUBMB): EC 3.4.222 EC 3.4.22.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG4B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ATG4B (NM_178326) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATG4B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG4B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG4B |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ATG4B for ontologies About GeneDecksing
Animal Models:
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Atg4b):
ATG4B for phenotypes About GeneDecksing
|
Pathways & Interactions
for ATG4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptosis and Autophagy | | | 2 | Regulation of IFNA signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for ATG4B
1 
Kegg Pathway (Kegg details for ATG4B):
ATG4B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG4B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/172 Interacting proteins for ATG4B (Q9Y4P11, 2, 3 ENSP000003842594) via UniProtKB, MINT, STRING, and/or I2D (see all 172)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| LINC00341 | Q9H7612, 3 | MINT-65506 I2D:
score=3 | | MAP1LC3B | Q9GZQ81, 2, 3, ENSP000002686074 | EBI-712014,EBI-373144 MINT-7262642 MINT-7715688 MINT-65407 MINT-7261325 MINT-8259478 MINT-7261368 I2D:
score=7 STRING: ENSP00000268607 | | GABARAPL2 | P605201, 2, 3, ENSP000000372434 | EBI-712014,EBI-2973440 MINT-63922 MINT-8255547 I2D:
score=7 STRING: ENSP00000037243 | | GABARAP | O951661, 2, 3, ENSP000003068664 | EBI-712014,EBI-712001 MINT-63271 I2D:
score=9 STRING: ENSP00000306866 | | SLX1B | Q9BQ833, ENSP000003289404 | I2D:
score=1 STRING: ENSP00000328940 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
ATG4B for ontologies About GeneDecksing
|
Drugs & Compounds
for ATG4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ATG4B
Search CenterWatch for drugs/clinical trials and news about ATG4B
|
Transcripts
for ATG4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATG4B gene (2 alternative transcripts): NM_013325.4 NM_178326.2 Unigene Cluster for ATG4B: Autophagy related 4B, cysteine peptidase Hs.283610 [show with all ESTs]Unigene Representative Sequence: AK12527718/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27): ENST00000405546(uc002wbw.3 uc010fzp.3) ENST00000402096 ENST00000404914(uc002wbv.3 uc010zox.2 uc010zoy.2 uc010zoz.2)
ENST00000491867 ENST00000400772 ENST00000494465 ENST00000483778 ENST00000479554
ENST00000475195 ENST00000419606 ENST00000465399 ENST00000468018 ENST00000482507(uc002wbu.3)
ENST00000493618 ENST00000425239 ENST00000415107 ENST00000400771 ENST00000430617
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG4B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ATG4B (NM_178326) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATG4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG4B |
Additional cDNA sequence: AB066215.1 AJ504652.1 AK027332.1 AK027462.1 AK027763.1 AK125277.1 AK296818.1 AK298109.1 AK302963.1 AK316167.1 AL050288.1 AL080168.1 AL133638.1 BC000719.2 BX648007.1 24/33 DOTS entries (see all 33): DT.100806180 DT.100852458 DT.100770594 DT.452866 DT.100852464 DT.100852460 DT.99989778 DT.100852471 DT.87002224 DT.102830339 DT.120930192 DT.40133226 DT.91832275 DT.100852454 DT.120930132 DT.120930182 DT.97778464 DT.120930201 DT.91665530 DT.95328398 DT.100641019 DT.100852455 DT.120930167 DT.95188813 24/472 AceView cDNA sequences (see all 472): BI914465 CR592790 BG760893 CB127403 BE669863 BQ437082 BU500778 BE301891 CR591872 BE408416 BG390587 BU857097 CR607129 AI692748 CR607059 BE302904 NM_013325 AW732877 CR620961 CR600855 AA443573 CR595851 BX427415 BQ276441
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for ATG4B (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | - | | - | | - | | - | | | | - | | | | - | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | - | | - | | - | | - | | | | - | | | | - | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | - | | - | | - | | - | | | | - | | | | - | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | |
| ExUns: | 13a | · | 13b | · | 13c | · | 13d | · | 13e | ^ | 14a | · | 14b | · | 14c |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ATG4B
|
Expression
for ATG4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATG4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCGCCGCT
About this image
See ATG4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATG4B
SOURCE GeneReport for Unigene cluster: Hs.283610
UniProtKB/Swiss-Prot: ATG4B_HUMAN, Q9Y4P1Tissue specificity: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas
SABiosciences Expression via Pathway-Focused PCR Array including ATG4B:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATG4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG4B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG4B |
Orthologs
for ATG4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ATG4B gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ATG4B1 |
ATG4 autophagy related 4 homolog B (S. cerevisiae) |
78.49(n)
85.71(a) |
|
404750 NM_213573.1 NP_998738.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ATG4B6 |
-- |
85(a) |
1 ↔ 1 |
3(30545599-30557980) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.143622 |
Xenopus laevis transcribed sequence with moderate similarity more |
75.4(n) |
|
BU908586.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
atg4b1 |
ATG4 autophagy related 4 homolog B (S. cerevisiae) |
69.64(n)
73.98(a) |
|
448859 NM_001089352.1 NP_001082821.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Atg46 |
Autophagy-specific gene 4 |
38(a) |
1 → many |
2L(1080911-1083378) |
worm
(Caenorhabditis elegans) |
Secernentea |
atg-4.16 |
AuTophaGy (yeast Atg homolog) family member (atg-4... |
32(a) |
1 → many |
I(13536955-13542402) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G599501 |
cysteine protease ATG4b |
45.09(n)
38.78(a) |
|
825165 NM_115858.6 NP_191554.1 |
rice
(Oryza sativa) |
Liliopsida |
Os04g06820001 |
hypothetical protein |
46.65(n)
37.68(a) |
|
4337435 NM_001060828.1 NP_001054293.1 |
ENSEMBL Gene Tree for ATG4B (if available)
TreeFam Gene Tree for ATG4B (if available) |
Paralogs
for ATG4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATG4B gene
- ATG4C2 ATG4A2 ATG4D2
4 SIMAP similar genes for ATG4B using alignment to 11 protein entries: ATG4B_HUMAN (see all proteins):DKFZp686G0859 ATG4A ATG4C ATG4D
ATG4B for paralogs About GeneDecksing
|
Genomic Variants
for ATG4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATG4B (242576628 - 242613272 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ATG4B
2 CNVs: 34635 8969 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG4B |
|
Disorders
/ Diseases
for ATG4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATG4B for disorders About GeneDecksing
OMIM gene information: 611338
OMIM disorders: --
4  diseases for ATG4B: About MalaCardschronic obstructive pulmonary disease pulmonary disease neuronitis carcinoma
Export disorders for ATG4B gene to outside databases
|
Publications
for ATG4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATG4B gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with ATG4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. (PubMed id 12446702)1, 2, 3, 9 Marino G....Lopez-Otin C. (2003)
- The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. (PubMed id 19322194)1, 2 Satoo K....Inagaki F. (2009)
- The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. (PubMed id 16325851)1, 2 Kumanomidou T.... Yamane T. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy. (PubMed id 16183633)1, 2 Sugawara K....Inagaki F. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. (PubMed id 15169837)1, 2 Kabeya Y....Yoshimori T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. (PubMed id 15187094)1, 9 Tanida I....Kominami E. (2004)
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External Searches for ATG4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ATG4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ATG4B gene
(According to HUGE)
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Specialized Databases showing ATG4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for ATG4B gene:
Search GeneIP for patents involving ATG4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ATG4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ATG4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG4B | | | OriGene Protein Over-expression Lysate for ATG4B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ATG4B | | OriGene 3'-UTR Clone for ATG4B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ATG4B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATG4B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG4B |
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| | Antibodies & Assays for ATG4B |
| | | | Search Tocris compounds for ATG4B |
| |  |  |  |  | | | | | | Recombinant Protein for ATG4B |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG4B |
|  |  |  | | | | ThermoFisher Antibodies for ATG4B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG4B |
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