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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATG4A Gene

protein-coding   GIFtS: 57
GCID: GC0XP107334

autophagy related 4A, cysteine peptidase

(Previous names: AUT-like 2, cysteine endopeptidase (S. cerevisiae), APG4...)
(Previous symbols: AUTL2, APG4A)
 Explore 2 diseases affiliated with
ATG4A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATG4A    

Aliases
for ATG4A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Autophagy Related 4A, Cysteine Peptidase1 2     APG4 Autophagy 4 Homolog A2
APG4A1 2 3     ATG4 Autophagy Related 4 Homolog A2
AUTL21 2 3     AUT-Like 2, Cysteine Endopeptidase2
Autophagy-Related Cysteine Endopeptidase 22 3     Autophagin 22
Autophagy-Related Protein 4 Homolog A2 3     Autophagin-23
AUT-Like 2 Cysteine Endopeptidase2 3     Cysteine Protease ATG4A2
HAPG4A1     Autophagin-23
APG4 Autophagy 4 Homolog A (S. Cerevisiae)1     EC 3.4.22.-3
ATG4 Autophagy Related 4 Homolog A (S. Cerevisiae)1     EC 3.4.228
AUT-Like 2, Cysteine Endopeptidase (S. Cerevisiae)1     

External Ids:    HGNC: 164891   Entrez Gene: 1152012   Ensembl: ENSG000001018447   OMIM: 3006635   UniProtKB: Q8WYN03   

Export aliases for ATG4A gene to outside databases

Previous GC identifers: GC0XP107142 GC0XP107221 GC0XP096957


Summaries
for ATG4A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ATG4A:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy
is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis,
non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a
role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a
member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of
cysteine proteases. Transcript variants that encode distinct isoforms have been identified. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: ATG4A_HUMAN, Q8WYN0
Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or
GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form
(form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine
(PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2
followed by MAP1LC3A and GABARAP

Gene Wiki entry for ATG4A


Genomic Views
for ATG4A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATG4A gene promoter:
         Nkx3-1   C/EBPbeta   Nkx2-2   C/EBPalpha   RORalpha1   Nkx6-1   POU2F1   COMP1   POU2F1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATG4A promoter sequence
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1-q22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.1-q22.3

ATG4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG4A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP107334:  view genomic region     (about GC identifiers)

Start:
 107,334,898 bp from pter      End:
 107,397,901 bp from pter
Size:
 63,004 bases      Orientation:
 plus strand

Proteins
for ATG4A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATG4A_HUMAN, Q8WYN0 (See protein sequence)
Recommended Name: Cysteine protease ATG4A  
Size: 398 amino acids; 45378 Da
Subcellular location: Cytoplasm (Probable)
2 PDB 3D structures from and Proteopedia for ATG4A:
2FUY (3D)        2P82 (3D)    
Secondary accessions: A6NCH2 B2RAZ7 D3DUY0 O95534 Q5JYY9 Q5JYZ0 Q86VE5 Q96KQ0 Q96KQ1
Alternative splicing: 4 isoforms:  Q8WYN0-1   Q8WYN0-2   Q8WYN0-3   Q8WYN0-5   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ATG4A: NX_Q8WYN0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WYN0

    • 4/14 DME Specific Peptides for ATG4A (Q8WYN0) (see all 14)
     WKPLLLI  RLWFTYR  AYYFIGF  EDFEILS 

    ATG4A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_443168.2  NP_840054.1  

    ENSEMBL proteins: 
     ENSP00000361306   ENSP00000298131   ENSP00000416218   ENSP00000361320   ENSP00000341833  
     ENSP00000378354   ENSP00000361328   ENSP00000438936  

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    Uscn Proteins for ATG4A

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS12446702


    ATG4A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ATG4A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATG4A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005078 Peptidase_C54

    Graphical View of Domain Structure for InterPro Entry Q8WYN0

    ProtoNet protein and cluster: Q8WYN0

    UniProtKB/Swiss-Prot: ATG4A_HUMAN, Q8WYN0
    Similarity: Belongs to the peptidase C54 family


    Function
    for ATG4A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATG4A_HUMAN, Q8WYN0
    Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or
    GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form
    (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine
    (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2
    followed by MAP1LC3A and GABARAP
    Enzyme regulation: Inhibited by N-ethylmaleimide

    Enzyme Numbers (IUBMB): EC 3.4.222 EC 3.4.22.-1

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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008234cysteine-type peptidase activity IDA12473658


    ATG4A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ATG4A:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for ATG4A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    2Regulation of IFNA signaling
    		Regulation of autophagy0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ATG4A
        Apoptosis and Autophagy


    1         Kegg Pathway  (Kegg details for ATG4A):
        Regulation of autophagy


    ATG4A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for ATG4A (Q8WYN02, 3 ENSP000003613064) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ82, 3, ENSP000002686074MINT-7715703 I2D: score=1 STRING: ENSP00000268607
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=6 STRING: ENSP00000363970
    GABARAPL2P605203, ENSP000000372434I2D: score=3 STRING: ENSP00000037243
    GABARAPO951663, ENSP000003068664I2D: score=5 STRING: ENSP00000306866
    RASSF5Q8WWW03I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA12473658
    GO:0006914autophagy IEA--
    GO:0015031protein transport IEA--


    ATG4A for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATG4A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATG4A
    Search CenterWatch for drugs/clinical trials and news about ATG4A 

    Transcripts
    for ATG4A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATG4A gene (3 alternative transcripts): 
    NM_052936.3  NM_178270.2  NM_178271.1  

    Unigene Cluster for ATG4A:

    Autophagy related 4A, cysteine peptidase
    Hs.8763  [show with all ESTs]
    Unigene Representative Sequence: BC041862
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372232(uc004enr.3 uc010npi.3) ENST00000345734(uc004ent.3)
    ENST00000457035 ENST00000372246(uc004ens.3 uc011msl.2) ENST00000343524
    ENST00000394892 ENST00000474825 ENST00000489247 ENST00000372254 ENST00000545696


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB066214.1 AJ320508.1 AJ320509.1 AJ504651.1 AK054927.1 AK293533.1 AK314429.1 BC041862.1 
    BC061696.1 

    11 DOTS entries:

    DT.92424932  DT.100794490  DT.100794484  DT.415942  DT.100794481  DT.100023367  DT.121291546  DT.91693496 
    DT.92424929  DT.92424930  DT.121291534 

    24/167 AceView cDNA sequences (see all 167):

    AI127937 BU683507 AI420352 BM541269 BX378154 CK819294 BX343291 BX400980 
    AA905599 AK054927 AL523527 CR625383 AW271386 BU630303 BG196673 CR616947 
    BU620926 BE550136 BM985380 AI358986 CR599663 BM981340 BI860999 BE348710 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ATG4A (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                -     -     -                                                                             -                           
    SP2:                                -     -     -           -     -                                                           -                           
    SP3:                                                        -     -                                   -     -           -     -                           
    SP4:                                      -     -           -     -                                                                                       
    SP5:                                                        -     -     -     -                                               -                           


    ECgene alternative splicing isoforms for ATG4A

    Expression
    for ATG4A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATG4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAAAGCAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ATG4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATG4A

    SOURCE GeneReport for Unigene cluster: Hs.8763

    UniProtKB/Swiss-Prot: ATG4A_HUMAN, Q8WYN0
    Tissue specificity: Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and
    brain. Also detected in fetal liver

        SABiosciences Expression via Pathway-Focused PCR Array including ATG4A: 
              Autophagy in human mouse rat

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    In Situ
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    Orthologs
    for ATG4A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATG4A gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ATG4A1 ATG4 autophagy related 4 homolog A (S. cerevisiae) 76.33(n)
    82.18(a)    		   772074  XM_003641116.1  XP_003641164.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ATG4A6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343202.1(3976535-3986869)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.40652 Transcribed sequence with moderate similarity to protein more 80.69(n)    AL846871.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii atg4a1 ATG4 autophagy related 4 homolog A (S. cerevisiae) 68.99(n)
    75.34(a)    		   554140  NM_001024434.1  NP_001019605.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Atg41 Autophagy-specific gene 4 52.67(n)
    46.06(a)    		   33283  NM_134719.3  NP_608563.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea atg-4.11 Protein ATG-4.1 50.23(n)
    44.38(a)    		   190777  NM_060974.3  NP_493375.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G599506
    AT2G441406
    		 cysteine protease ATG4a
    		 24(a)
    23(a)
    		 many ↔ many
    many ↔ many
    		 3(22144280-22147691)
    2(18253497-18258035)
    rice
    (Oryza sativa)    		 Liliopsida Atg46
    --
    		 cysteine protease ATG4, putative, expressed
    		 25(a)
    23(a)
    		 many ↔ many
    many ↔ many
    		 4(34631535-34634977)
    3(15660498-15664317)


    ENSEMBL Gene Tree for ATG4A (if available)
    TreeFam Gene Tree for ATG4A (if available) 

    Paralogs
    for ATG4A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATG4A gene
    ATG4C2  ATG4D2  ATG4B2  
    2 SIMAP similar genes for ATG4A using alignment to 5 protein entries:     ATG4A_HUMAN (see all proteins):
    ATG4B    ATG4D

    ATG4A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATG4A
    PGOHUM00000241877


    Genomic Variants
    for ATG4A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/522 NCBI SNPs in ATG4A are shown (see all 522)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1819173631,2
    		--107336953(+) TGCCAA/GCATTT 2 -- int10--------
    rs1862617521,2
    		--107337048(+) TTATAA/GTACGG 2 -- int10--------
    rs8071831,2
    		C,F,A,H,--107337493(+) TGAGAG/ATCTAA 2 -- int115Minor allele frequency- A:0.44NS EA NA WA CSA 1775
    rs626013791,2
    		C,--107337798(+) GAGTAT/CTGGTC 2 -- int11Minor allele frequency- C:0.00NA 2
    rs1907295621,2
    		--107338186(+) AACTTC/TTATTT 2 -- int10--------
    rs1815228531,2
    		--107338219(+) TCACTC/GTGTCA 2 -- int10--------
    rs1857922471,2
    		--107338294(+) ATTCTC/TCTGCC 2 -- int10--------
    rs1113956431,2
    		--107338314(+) TGAGGT/CGCATG 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs8071841,2
    		C,F,A,--107338552(+) CTAGCT/ACAAGC 2 -- int13Minor allele frequency- A:0.50NA WA 6
    rs1830719021,2
    		--107338635(+) TTTTTA/GTAGAT 2 -- int10--------

    HapMap Linkage Disequilibrium report for ATG4A (107334898 - 107397901 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ATG4A: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ATG4A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATG4A for disorders           About GeneDecksing

    OMIM gene information: 300663    OMIM disorders: --

    2 diseases for ATG4A:    About MalaCards
    crohn's disease    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ATG4A (2 documents)

    Export disorders for ATG4A gene to outside databases

    Publications
    for ATG4A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATG4A gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ATG4A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. (PubMed id 12446702)1, 2, 3 Marino G....Lopez-Otin C. (2003)
    2. The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A. (PubMed id 12473658)1, 2, 3 Scherz-Shouval R.... Elazar Z. (2003)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. (PubMed id 15169837)1, 2 Kabeya Y....Yoshimori T. (2004)
    7. Kinetics comparisons of mammalian Atg4 homologues ind icate selective preferences toward diverse Atg8 substrates. (PubMed id 21177865)1 Li M....Yin X.M. (2011)
    8. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1 Zhang X....Wu X. (2010)
    9. Granulomas in Crohn's disease: are newly discovered g enetic variants involved? (PubMed id 21122541)1 Mazor Y....Eliakim R. (2010)
    10. A systematic bioinformatics approach for selection of target and screening of ligand for malignant tumours suppressing APG4A gene on Xq22.1. (PubMed id 21297227)1 Niranjan V....Sivakumar G. (2010)

    External Searches for ATG4A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ATG4A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115201 HGNC: 16489 AceView: APG4A Ensembl:ENSG00000101844 euGenes: HUgn115201
    ECgene: ATG4A Kegg: 115201 H-InvDB: ATG4A

    Other Databases showing ATG4A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATG4A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATG4A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ATG4A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ATG4A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATG4A gene:
    Search GeneIP for patents involving ATG4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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