Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATG4A Gene

Aliases for ATG4A Gene

  • Autophagy Related 4A Cysteine Peptidase 2 3
  • Autophagy Related 4A, Cysteine Peptidase 2 3 5
  • Autophagy-Related Cysteine Endopeptidase 2 3 4
  • Autophagy-Related Protein 4 Homolog A 3 4
  • AUT-Like 2 Cysteine Endopeptidase 3 4
  • Autophagin-2 3 4
  • HAPG4A 3 4
  • APG4A 3 4
  • AUTL2 3 4
  • AUT-Like 2, Cysteine Endopeptidase (S. Cerevisiae) 2
  • ATG4 Autophagy Related 4 Homolog A (S. Cerevisiae) 2
  • APG4 Autophagy 4 Homolog A (S. Cerevisiae) 2
  • ATG4 Autophagy Related 4 Homolog A 3
  • AUT-Like 2, Cysteine Endopeptidase 3
  • APG4 Autophagy 4 Homolog A 3
  • Autophagin 2 3
  • EC 3.4.22.- 4
  • EC 3.4.22 63

External Ids for ATG4A Gene

Previous HGNC Symbols for ATG4A Gene

  • AUTL2
  • APG4A

Previous GeneCards Identifiers for ATG4A Gene

  • GC0XP107142
  • GC0XP107221
  • GC0XP107334
  • GC0XP096957

Summaries for ATG4A Gene

Entrez Gene Summary for ATG4A Gene

  • Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Mar 2016]

GeneCards Summary for ATG4A Gene

ATG4A (Autophagy Related 4A Cysteine Peptidase) is a Protein Coding gene. Among its related pathways are Cellular Senescence and p53 Pathway (RnD). GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is ATG4B.

UniProtKB/Swiss-Prot for ATG4A Gene

  • Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Gene Wiki entry for ATG4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG4A Gene

Genomics for ATG4A Gene

Regulatory Elements for ATG4A Gene

Promoters for ATG4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATG4A on UCSC Golden Path with GeneCards custom track

Genomic Location for ATG4A Gene

Chromosome:
X
Start:
108,088,916 bp from pter
End:
108,154,671 bp from pter
Size:
65,756 bases
Orientation:
Plus strand

Genomic View for ATG4A Gene

Genes around ATG4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG4A Gene

Proteins for ATG4A Gene

  • Protein details for ATG4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYN0-ATG4A_HUMAN
    Recommended name:
    Cysteine protease ATG4A
    Protein Accession:
    Q8WYN0
    Secondary Accessions:
    • A6NCH2
    • B2RAZ7
    • D3DUY0
    • O95534
    • Q5JYY9
    • Q5JYZ0
    • Q86VE5
    • Q96KQ0
    • Q96KQ1

    Protein attributes for ATG4A Gene

    Size:
    398 amino acids
    Molecular mass:
    45378 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ATG4A Gene

    Alternative splice isoforms for ATG4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG4A Gene

Proteomics data for ATG4A Gene at MOPED

Post-translational modifications for ATG4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ATG4A (ATG4A)

Domains & Families for ATG4A Gene

Gene Families for ATG4A Gene

Protein Domains for ATG4A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYN0

UniProtKB/Swiss-Prot:

ATG4A_HUMAN :
  • Belongs to the peptidase C54 family.
Family:
  • Belongs to the peptidase C54 family.
genes like me logo Genes that share domains with ATG4A: view

Function for ATG4A Gene

Molecular function for ATG4A Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=33.9 uM for MAP1LC3B {ECO:0000269 PubMed:21177865, ECO:0000269 PubMed:22302004}; KM=20.8 uM for GABARAP {ECO:0000269 PubMed:21177865, ECO:0000269 PubMed:22302004}; KM=36.7 uM for GABARAPL1 {ECO:0000269 PubMed:21177865, ECO:0000269 PubMed:22302004}; KM=15.7 uM for GABARAPL2 {ECO:0000269 PubMed:21177865, ECO:0000269 PubMed:22302004};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide. Redox-regulated during autophagy since reducing conditions activate ATG4A whereas an oxidizing environment such as the presence of H(2)O(2) inhibits its activity.
UniProtKB/Swiss-Prot Function:
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Enzyme Numbers (IUBMB) for ATG4A Gene

genes like me logo Genes that share phenotypes with ATG4A: view

Animal Model Products

miRNA for ATG4A Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG4A Gene

Localization for ATG4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG4A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG4A Gene COMPARTMENTS Subcellular localization image for ATG4A gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2
vacuole 2
lysosome 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ATG4A Gene

Pathways & Interactions for ATG4A Gene

genes like me logo Genes that share pathways with ATG4A: view

Pathways by source for ATG4A Gene

1 GeneTex pathway for ATG4A Gene
2 Reactome pathways for ATG4A Gene
1 KEGG pathway for ATG4A Gene
2 R&D Systems pathways for ATG4A Gene

Gene Ontology (GO) - Biological Process for ATG4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IBA --
GO:0006508 proteolysis IEA,IDA 12473658
GO:0006914 autophagy IEA --
GO:0016485 protein processing IBA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with ATG4A: view

No data available for SIGNOR curated interactions for ATG4A Gene

Drugs & Compounds for ATG4A Gene

(8) Drugs for ATG4A Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nimodipine Approved Pharma Potentiation, Activator 20
Omeprazole Approved, Investigational Pharma Activator H+,K+-ATPase inhibitor 321
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
Chloroquine diphosphate Pharma Antimalarial drug 141
Dexamethasone (DHAP) Pharma Glucocorticoidan;ti-inflammatory 0
genes like me logo Genes that share compounds with ATG4A: view

Transcripts for ATG4A Gene

Unigene Clusters for ATG4A Gene

Autophagy related 4A, cysteine peptidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATG4A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - -
SP7: - -
SP8:
SP9: -

Relevant External Links for ATG4A Gene

GeneLoc Exon Structure for
ATG4A
ECgene alternative splicing isoforms for
ATG4A

Expression for ATG4A Gene

mRNA expression in normal human tissues for ATG4A Gene

Protein differential expression in normal tissues from HIPED for ATG4A Gene

This gene is overexpressed in Saliva (37.1), Pancreas (19.5), and Gallbladder (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG4A Gene



SOURCE GeneReport for Unigene cluster for ATG4A Gene Hs.8763

mRNA Expression by UniProt/SwissProt for ATG4A Gene

Q8WYN0-ATG4A_HUMAN
Tissue specificity: Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.
genes like me logo Genes that share expression patterns with ATG4A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ATG4A Gene

Orthologs for ATG4A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATG4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG4A 35
  • 99.66 (n)
  • 99.5 (a)
ATG4A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATG4A 36
  • 95 (a)
OneToOne
ATG4A 35
  • 92.63 (n)
  • 95.23 (a)
dog
(Canis familiaris)
Mammalia ATG4A 35
  • 92.38 (n)
  • 94.22 (a)
ATG4A 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg4a 16
Atg4a 35
  • 90.44 (n)
  • 93.15 (a)
Atg4a 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATG4A 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG4A 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg4al1 35
  • 91.54 (n)
  • 93.22 (a)
chicken
(Gallus gallus)
Aves ATG4A 36
  • 81 (a)
OneToOne
ATG4A 35
  • 76.68 (n)
  • 81.98 (a)
lizard
(Anolis carolinensis)
Reptilia ATG4A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg4a 35
  • 73.14 (n)
  • 75.47 (a)
Str.4065 35
zebrafish
(Danio rerio)
Actinopterygii atg4a 35
  • 69.25 (n)
  • 75.62 (a)
atg4a 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008497 35
  • 51.55 (n)
  • 46.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atg4 36
  • 37 (a)
OneToMany
Atg4 35
  • 52.89 (n)
  • 46.81 (a)
worm
(Caenorhabditis elegans)
Secernentea atg-4.1 36
  • 33 (a)
OneToMany
atg-4.1 35
  • 50.38 (n)
  • 45.11 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL191W 35
  • 45.77 (n)
  • 33.21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG4 35
  • 45.48 (n)
  • 33.46 (a)
ATG4 36
  • 19 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19536g 35
  • 48.27 (n)
  • 37.04 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G59950 35
  • 47.35 (n)
  • 40.28 (a)
rice
(Oryza sativa)
Liliopsida Os04g0682000 35
  • 46.1 (n)
  • 40.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2997 36
  • 40 (a)
OneToMany
Species with no ortholog for ATG4A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG4A Gene

ENSEMBL:
Gene Tree for ATG4A (if available)
TreeFam:
Gene Tree for ATG4A (if available)

Paralogs for ATG4A Gene

Paralogs for ATG4A Gene

(2) SIMAP similar genes for ATG4A Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ATG4A Gene

genes like me logo Genes that share paralogs with ATG4A: view

Variants for ATG4A Gene

Sequence variations from dbSNP and Humsavar for ATG4A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs807183 -- 108,094,263(+) tgaga(A/G)tctaa intron-variant
rs807184 -- 108,095,322(+) ctagc(A/T)caagc intron-variant
rs807185 -- 108,097,488(+) CATGT(A/T)GCTCT intron-variant
rs2179370 -- 108,146,478(+) gatgg(C/T)tgagt intron-variant
rs2294462 -- 108,138,169(+) AACGC(A/G)TATTA intron-variant, reference, synonymous-codon

Variation tolerance for ATG4A Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG4A Gene

HapMap Linkage Disequilibrium report
ATG4A
Human Gene Mutation Database (HGMD)
ATG4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATG4A Gene

Disorders for ATG4A Gene

Relevant External Links for ATG4A

Genetic Association Database (GAD)
ATG4A
Human Genome Epidemiology (HuGE) Navigator
ATG4A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG4A

No disorders were found for ATG4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG4A Gene

Publications for ATG4A Gene

  1. Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. (PMID: 12446702) Marino G. … Lopez-Otin C. (J. Biol. Chem. 2003) 2 3 4 67
  2. The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A. (PMID: 12473658) Scherz-Shouval R. … Elazar Z. (J. Biol. Chem. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy. (PMID: 25490467) Borel S. … Biard-Piechaczyk M. (AIDS 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ATG4A Gene

Sources for ATG4A Gene

Back to Top

Content