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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATG3 Gene

protein-coding   GIFtS: 54
GCID: GC03M112251

autophagy related 3

(Previous names: APG3 autophagy 3-like (S. cerevisiae), ATG3 autophagy related...)
(Previous symbol: APG3L)
 Explore 4 diseases affiliated with
ATG3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATG3    

Aliases
for ATG3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Autophagy Related 31 2     APG3 Autophagy 3-Like (S. Cerevisiae)1
APG3L1 2 3     ATG3 Autophagy Related 3 Homolog (S. Cerevisiae)1
PC3-961 2     2610016C12Rik2
Autophagy-Related Protein 32 3     APG3-LIKE2
APG32 3     ATG3 Autophagy Related 3 Homolog2
HApg31     Ubiquitin-Like-Conjugating Enzyme ATG32
DKFZp564M11781     APG3-Like1
FLJ221251     EC 6.3.2.-3
MGC152011     Protein PC3-963

External Ids:    HGNC: 209621   Entrez Gene: 644222   Ensembl: ENSG000001448487   OMIM: 6096065   UniProtKB: Q9NT623   

Export aliases for ATG3 gene to outside databases

Previous GC identifers: GC03M113735 GC03M109636


Summaries
for ATG3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ATG3:
Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome or vacuole. Human ATG3 displays
the same enzymatic characteristics in vitro as yeast Apg3, a protein-conjugating enzyme essential for autophagy
(Tanida et al., 2002 (PubMed 11825910)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ATG3_HUMAN, Q9NT62
Function: E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like
proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like
proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme,
catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis
but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3




Genomic Views
for ATG3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATG3 gene promoter:
         Nkx3-1   Nkx3-1 v1   STAT5A   YY1   Nkx3-1 v2   MEF-2A   FOXO1a   ZID   MRF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

ATG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112251:  view genomic region     (about GC identifiers)

Start:
 112,251,356 bp from pter      End:
 112,280,893 bp from pter
Size:
 29,538 bases      Orientation:
 minus strand

Proteins
for ATG3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATG3_HUMAN, Q9NT62 (See protein sequence)
Recommended Name: Ubiquitin-like-conjugating enzyme ATG3  
Size: 314 amino acids; 35864 Da
Subunit: Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of
ATG12 to ATG5. Interacts with FNBP1L
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAB15237.1; Type=Erroneous initiation;
Secondary accessions: Q6PKC5 Q9H6L9
Alternative splicing: 2 isoforms:  Q9NT62-1   Q9NT62-2   (No experimental confirmation available. Ref.4 (AAH02830) sequence differs from that shown due to a frameshift in position 311)

Explore the universe of human proteins at neXtProt for ATG3: NX_Q9NT62

Post-translational modifications:

  • Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell
    • death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NT62

    • ATG3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_071933.2  
    ENSEMBL proteins: 
     ENSP00000283290   ENSP00000385943   ENSP00000420259   ENSP00000420378  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: ATG3
    OriGene Protein Over-expression Lysate: ATG3
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    Novus Biologicals ATG3 Proteins
    Novus Biologicals ATG3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ATG3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000153cytoplasmic ubiquitin ligase complex IPI11825910
    GO:0005829cytosol IDA11825910


    ATG3 for ontologies           About GeneDecksing



    ATG3 Antibody Products: 
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    Uscn ELISAs and CLIAs for ATG3

    Protein Domains /
    Families
    for ATG3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATG3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR019461 Autophagy-rel_prot_3_C
     IPR007135 Autophagy-rel_prot_3
     IPR007134 Autophagy-rel_prot_3_N

    Graphical View of Domain Structure for InterPro Entry Q9NT62

    ProtoNet protein and cluster: Q9NT62

    UniProtKB/Swiss-Prot: ATG3_HUMAN, Q9NT62
    Similarity: Belongs to the ATG3 family


    Function
    for ATG3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATG3_HUMAN, Q9NT62
    Function: E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like
    proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like
    proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme,
    catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis
    but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    OriGene 3'-UTR Clone: ATG3
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATG3:
    hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ATG3 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: ATG3
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019776Atg8 ligase activity ISS--
    GO:0019777Atg12 ligase activity ISS--
    GO:0019787small conjugating protein ligase activity IDA11825910
    GO:0019899enzyme binding IPI11825910


    ATG3 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Atg3):
     cellular  hematopoietic system  immune system 

    ATG3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATG3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    2Senescence and Autophagy
    		Senescence and Autophagy1.00
    3Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00
    4Regulation of IFNA signaling
    		Regulation of autophagy0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for ATG3
        Apoptosis and Autophagy
    Glucose / Energy Metabolism

    1 BioSystems Pathway for ATG3 
        Senescence and Autophagy


    1         Kegg Pathway  (Kegg details for ATG3):
        Regulation of autophagy


    ATG3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/215 Interacting proteins for ATG3 (Q9NT621, 3 ENSP000002832904) via UniProtKB, MINT, STRING, and/or I2D (see all 215)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TECPR1Q7Z6L11, 3, ENSP000004049234EBI-988094,EBI-2946676 I2D: score=4 STRING: ENSP00000404923
    GABARAPO951661, 3, ENSP000003068664EBI-988094,EBI-712001 I2D: score=5 STRING: ENSP00000306866
    MAP1LC3BQ9GZQ81, 3, ENSP000002686074EBI-988094,EBI-373144 I2D: score=4 STRING: ENSP00000268607
    GABARAPL2P605201, 3, ENSP000000372434EBI-988094,EBI-2973440 I2D: score=5 STRING: ENSP00000037243
    SLX1BQ9BQ833, ENSP000003289404I2D: score=1 STRING: ENSP00000328940
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ISS--
    GO:0006464cellular protein modification process IDA11825910
    GO:0006612protein targeting to membrane ISS--
    GO:0006914autophagy ----
    GO:0016567protein ubiquitination IDA11825910


    ATG3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATG3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATG3
    Search CenterWatch for drugs/clinical trials and news about ATG3 

    Transcripts
    for ATG3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATG3 gene: 
    NM_022488.3  

    Unigene Cluster for ATG3:

    Autophagy related 3
    Hs.477126  [show with all ESTs]
    Unigene Representative Sequence: BC002830
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283290(uc003dzd.3) ENST00000402314(uc003dzc.3) ENST00000494571
    ENST00000495756(uc010hqe.3) ENST00000467275 ENST00000496423 ENST00000492886
    ENST00000465980 ENST00000488910

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATG3:
    hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ATG3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG3

    Additional cDNA sequence: 

    AB079384.1 AF202092.1 AK025778.1 AK123511.1 AK307432.1 AK308919.1 AL137515.1 BC002830.1 
    BC024221.2 BC043267.1 

    21 DOTS entries:

    DT.91762273  DT.100790037  DT.91762274  DT.116917  DT.315607  DT.92426391  DT.91762293  DT.100031349 
    DT.91841273  DT.95257119  DT.100790035  DT.91762280  DT.92033201  DT.100790034  DT.100790036  DT.86854393 
    DT.91762281  DT.97846905  DT.120895630  DT.120895670  DT.99996501 

    24/349 AceView cDNA sequences (see all 349):

    AI753516 BM793909 BU687082 BX363198 BQ774710 BU626468 BU688604 BQ788060 
    BM707999 BM745334 BU733670 AI783787 CA445533 BM015427 CR623472 AF202092 
    AA630116 AA449700 AI424878 F03691 BU675802 BU683319 CA422470 AA678050 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ATG3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                                                                            -         
    SP2:                                                                                                      
    SP3:        -     -                                                                                       
    SP4:                                      -     -                                                         
    SP5:                          -                                                                           


    ECgene alternative splicing isoforms for ATG3

    Expression
    for ATG3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGAGGTGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ATG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATG3

    SOURCE GeneReport for Unigene cluster: Hs.477126

    UniProtKB/Swiss-Prot: ATG3_HUMAN, Q9NT62
    Tissue specificity: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including ATG3: 
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              Cell Death PathwayFinder in human mouse rat

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    In Situ
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    Orthologs
    for ATG3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATG3 gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Atg31 , 5 autophagy-related 3 (yeast)5
    autophagy related 31    		 92.36(n)1
    97.45(a)1    		   16 (29.45 cM)5
    678411  NM_026402.31  NP_080678.11 
     451587855 
    chicken
    (Gallus gallus)    		 Aves ATG31 ATG3 autophagy related 3 homolog (S. cerevisiae) 84.45(n)
    92.65(a)    		   418369  XM_416588.2  XP_416588.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ATG36
    		 --
    		 91(a)
    		 1 ↔ 1
    		 3(175766637-175786115)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.126292 Xenopus laevis, clone IMAGE5542698, mRNA 80.75(n)    BC045018.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb15g122 wufb15g12 80.41(n)   336632  BC057434.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Aut11 Aut1 63.03(n)
    66.67(a)    		   40044  NM_140802.2  NP_649059.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea atg-31 Protein ATG-3 58.68(n)
    57.99(a)    		   176921  NM_067623.3  NP_500024.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATG31 autophagy-related protein 3 57.97(n)
    51.09(a)    		   836271  NM_125543.4  NP_568934.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.276652 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.67(n)    AK067737.1 


    ENSEMBL Gene Tree for ATG3 (if available)
    TreeFam Gene Tree for ATG3 (if available) 

    Paralogs
    for ATG3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATG3 gene

    ATG3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATG3
    PGOHUM00000247532


    Genomic Variants
    for ATG3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/484 NCBI SNPs in ATG3 are shown (see all 484)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs29331401,2
    		C,F,A,H,--112250872(-) TATTCT/CCTTTA 1 -- int117Minor allele frequency- C:0.02NS EA NA WA CSA 793
    rs340808151,2
    		C,F,--112250934(+) ACTTGC/TCTTTC 1 -- int14Minor allele frequency- T:0.05NA EA 244
    rs1470642611,2
    		C,--112251056(+) AAAAA-/TAATTT 1 -- int10--------
    rs1436849881,2
    		--112251073(+) TATCAA/GTATCA 1 -- int10--------
    rs2005845701,2
    		--112251111(+) GTACT-/TAAAGAG 1 -- int10--------
    rs593336341,2
    		C--112251112(+) TACTTAA/-AGAGT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs722960271,2
    		C,--112251112(+) ACTTA-/AAGAGTT 1 -- int10--------
    rs1996083941,2
    		C--112251113(+) ACTTAA/GAGAGT 1 -- int10--------
    rs1463420491,2
    		--112251404(+) GGAACA/GTATTT 1 -- ut310--------
    rs1161100151,2
    		--112251437(+) AGTCCA/CTTATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ATG3 (112251356 - 112280893 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ATG3: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ATG3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATG3 for disorders           About GeneDecksing

    OMIM gene information: 609606    OMIM disorders: --

    4 diseases for ATG3:    About MalaCards
    molluscum contagiosum    huntington's disease    malaria    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: ATG3 (1 document)

    Export disorders for ATG3 gene to outside databases

    Publications
    for ATG3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATG3 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with ATG3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. (PubMed id 11825910)1, 2, 3, 9 Tanida I.... Kominami E. (2002)
    2. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. (PubMed id 19342671)1, 2 Huett A....Xavier R.J. (2009)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Cleavage of Atg3 protein by caspase-8 regulates autoph agy during receptor-activated cell death. (PubMed id 22644571)1 Oral O....Gozuacik D. (2012)

    External Searches for ATG3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ATG3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64422 HGNC: 20962 AceView: APG3L Ensembl:ENSG00000144848 euGenes: HUgn64422
    ECgene: ATG3 Kegg: 64422 H-InvDB: ATG3

    Other Databases showing ATG3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATG3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATG3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATG3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATG3 gene:
    Search GeneIP for patents involving ATG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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