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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATG3 Gene

protein-coding   GIFtS: 56
GCID: GC03M112251

Autophagy Related 3

(Previous names: APG3 autophagy 3-like (S. cerevisiae), ATG3 autophagy related...)
(Previous symbol: APG3L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Autophagy Related 31 2     APG3-LIKE2
APG3L1 2 3     PC3-962
Autophagy-Related Protein 32 3     ATG3 Autophagy Related 3 Homolog2
APG32 3     Ubiquitin-Like-Conjugating Enzyme ATG32
hApg32 3     APG3-like3
APG3 Autophagy 3-Like (S. Cerevisiae)1     EC 6.3.2.-3
ATG3 Autophagy Related 3 Homolog (S. Cerevisiae)1     Protein PC3-963
2610016C12Rik2     

External Ids:    HGNC: 209621   Entrez Gene: 644222   Ensembl: ENSG000001448487   OMIM: 6096065   UniProtKB: Q9NT623   

Export aliases for ATG3 gene to outside databases

Previous GC identifers: GC03M113735 GC03M109636


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ATG3 Gene:
This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved
in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells.
This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is
located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for ATG3 Gene: 
ATG3 (autophagy related 3) is a protein-coding gene. Diseases associated with ATG3 include molluscum contagiosum, and huntington's disease. GO annotations related to this gene include Atg12 ligase activity and enzyme binding.

UniProtKB/Swiss-Prot: ATG3_HUMAN, Q9NT62
Function: E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of
ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation
to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic
E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in
mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an
E1-E2 complex with ATG3




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATG3 gene promoter:
         Nkx3-1   Nkx3-1 v1   STAT5A   YY1   Nkx3-1 v2   MEF-2A   FOXO1a   ZID   MRF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

ATG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112251:  view genomic region     (about GC identifiers)

Start:
112,251,356 bp from pter      End:
112,280,893 bp from pter
Size:
29,538 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATG3_HUMAN, Q9NT62 (See protein sequence)
Recommended Name: Ubiquitin-like-conjugating enzyme ATG3  
Size: 314 amino acids; 35864 Da
Subunit: Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of
ATG12 to ATG5. Interacts with FNBP1L
Subcellular location: Cytoplasm
Sequence caution: Sequence=BAB15237.1; Type=Erroneous initiation;
Secondary accessions: Q6PKC5 Q9H6L9
Alternative splicing: 2 isoforms:  Q9NT62-1   Q9NT62-2   (No experimental confirmation available. Ref.4 (AAH02830) sequence differs from that shown due to a frameshift in position 311)

Explore the universe of human proteins at neXtProt for ATG3: NX_Q9NT62

Explore proteomics data for ATG3 at MOPED 

Post-translational modifications:

  • UniProtKB: Conjugated to ATG12 at Lys-243. ATG12-conjugation plays a role in regulation of mitochondrial homeostasis and cell
    death, while it is not involved in PE-conjugation to ATG8-like proteins and autophagy (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NT62

  • ATG3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATG3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265641.1  NP_071933.2  

    ENSEMBL proteins: 
     ENSP00000283290   ENSP00000385943   ENSP00000420259   ENSP00000420378  

    Human Recombinant Protein Products for ATG3: 
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    Cloud-Clone Corp. Proteins for ATG3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000153cytoplasmic ubiquitin ligase complex IPI11825910
    GO:0005829cytosol IDA11825910

    ATG3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR019461 Autophagy-rel_prot_3_C
     IPR007135 Autophagy-rel_prot_3
     IPR007134 Autophagy-rel_prot_3_N

    Graphical View of Domain Structure for InterPro Entry Q9NT62

    ProtoNet protein and cluster: Q9NT62

    UniProtKB/Swiss-Prot: ATG3_HUMAN, Q9NT62
    Similarity: Belongs to the ATG3 family


    ATG3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATG3_HUMAN, Q9NT62
    Function: E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of
    ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation
    to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic
    E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in
    mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an
    E1-E2 complex with ATG3

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11825910
    GO:0019776Atg8 ligase activity ISS--
    GO:0019777Atg12 ligase activity ISS--
    GO:0019787small conjugating protein ligase activity IDA11825910
    GO:0019899enzyme binding IPI11825910
         
    ATG3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Atg3):
     cellular  hematopoietic system  immune system 

    ATG3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ATG3 
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    miRTarBase miRNAs that target ATG3:
    hsa-mir-155 (MIRT001566)

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATG3:
    hsa-miR-548c-3p
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATG3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy
    2Regulation of autophagy
    Regulation of autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ATG3
        Senescence and Autophagy



    1         Kegg Pathway  (Kegg details for ATG3):
        Regulation of autophagy


    ATG3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/237 Interacting proteins for ATG3 (Q9NT621, 3 ENSP000002832904) via UniProtKB, MINT, STRING, and/or I2D (see all 237)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ISS--
    GO:0006464cellular protein modification process IDA11825910
    GO:0006612protein targeting to membrane ISS--
    GO:0006914autophagy ----
    GO:0016567protein ubiquitination IDA11825910

    ATG3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATG3

    Search CenterWatch for drugs/clinical trials and news about ATG3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATG3 gene (2 alternative transcripts): 
    NM_001278712.1  NM_022488.4  

    Unigene Cluster for ATG3:

    Autophagy related 3
    Hs.477126  [show with all ESTs]
    Unigene Representative Sequence: BC002830
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283290(uc003dzd.3) ENST00000402314(uc003dzc.3) ENST00000494571
    ENST00000495756(uc010hqe.3) ENST00000467275 ENST00000496423 ENST00000492886
    ENST00000465980 ENST00000488910
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ATG3:
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    Additional mRNA sequence: 

    AB079384.1 AF202092.1 AK025778.1 AK123511.1 AK307432.1 AK308919.1 AL137515.1 BC002830.1 
    BC024221.2 BC043267.1 

    21 DOTS entries:

    DT.91762273  DT.100790037  DT.91762274  DT.116917  DT.315607  DT.92426391  DT.91762293  DT.100031349 
    DT.91841273  DT.95257119  DT.100790035  DT.91762280  DT.92033201  DT.100790034  DT.100790036  DT.86854393 
    DT.91762281  DT.97846905  DT.120895630  DT.120895670  DT.99996501 

    24/349 AceView cDNA sequences (see all 349):

    CR601674 NM_022488 BG195055 BU678408 AI753516 CR608289 AF202092 CR623472 
    BM795899 BU675802 AA883741 BM015427 BM793909 BQ774710 CR619599 BQ788060 
    BU688604 AI424878 BM980777 BU733670 AI718106 CR594782 BU687082 BU683319 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ATG3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                                                                            -         
    SP2:                                                                                                      
    SP3:        -     -                                                                                       
    SP4:                                      -     -                                                         
    SP5:                          -                                                                           


    ECgene alternative splicing isoforms for ATG3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATG3 expression in normal human tissues (normalized intensities)      ATG3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGGTGAT
    ATG3 Expression
    About this image


    ATG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood

    See ATG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATG3

    SOURCE GeneReport for Unigene cluster: Hs.477126

    UniProtKB/Swiss-Prot: ATG3_HUMAN, Q9NT62
    Tissue specificity: Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and
    placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including ATG3: 
              Autophagy in human mouse rat
              Cell Death PathwayFinder in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATG3 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg31 , 5 autophagy-related 3 (yeast)5
    autophagy related 31
    92.36(n)1
    97.45(a)1
      16 (29.45 cM)5
    678411  NM_026402.31  NP_080678.11 
     451587855 
    chicken
    (Gallus gallus)
    Aves ATG31 ATG3 autophagy related 3 homolog (S. cerevisiae) 84.45(n)
    92.65(a)
      418369  XM_416588.2  XP_416588.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATG36
    Autophagy-related protein 3
    90(a)
    1 ↔ 1
    3(175764454-175786320)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.126292 Xenopus laevis, clone IMAGE5542698, mRNA 80.75(n)    BC045018.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb15g122 wufb15g12 80.41(n)   336632  BC057434.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aut11 Aut1 63.03(n)
    66.67(a)
      40044  NM_140802.2  NP_649059.1 
    worm
    (Caenorhabditis elegans)
    Secernentea atg-31 Protein ATG-3 58.68(n)
    57.99(a)
      176921  NM_067623.3  NP_500024.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG3(YNR007C)4 E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole more   --   14(640114-639182) 855741  NP_014404.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATG31 autophagy-related protein 3 57.97(n)
    51.09(a)
      836271  NM_125543.4  NP_568934.1 
    rice
    (Oryza sativa)
    Liliopsida Os.276652 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.67(n)    AK067737.1 


    ENSEMBL Gene Tree for ATG3 (if available)
    TreeFam Gene Tree for ATG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATG3 gene

    ATG3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ATG3
    PGOHUM00000247532


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/572 SNPs in ATG3 are shown (see all 572)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs678233751,2
    C--109657689(-) CAAAT-/TAAAC 
            
    TAGAG
    1 -- int12Minor allele frequency- TAAAC:0.25NA 4
    rs675713981,2
    C--112222089(-) GTGTC-/TTT   
       
    /TTTT
    TTTTT
    2 -- int1 cds12NA 4
    rs29331401,2
    C,F,A,H--112250872(-) TATTCT/CCTTTA 1 -- int117Minor allele frequency- C:0.02NS EA NA WA CSA 793
    rs340808151,2
    C,F--112250934(+) ACTTGC/TCTTTC 1 -- int14Minor allele frequency- T:0.05NA EA 244
    rs1470642611,2
    C--112251056(+) AAAAA-/TAATTT 1 -- int10--------
    rs1436849881,2
    C--112251073(+) TATCAA/GTATCA 1 -- int10--------
    rs2005845701,2
    --112251111(+) GTACT-/TAAAGAG 1 -- int10--------
    rs593336341,2
    C--112251112(+) TACTTAA/-AGAGT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1996083941,2
    C--112251113(+) ACTTAA/GAGAGT 1 -- int10--------
    rs1463420491,2
    --112251404(+) GGAACA/GTATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ATG3 (112251356 - 112280893 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ATG3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272571CNV Insertion20981092
    nsv877342CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609606    OMIM disorders: --

    2 diseases for ATG3:    About MalaCards
    molluscum contagiosum    huntington's disease


    ATG3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATG3
    Human Genome Epidemiology (HuGE) Navigator: ATG3 (1 document)

    Export disorders for ATG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATG3 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with ATG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. (PubMed id 11825910)1, 2, 3, 9 Tanida I.... Kominami E. (2002)
    2. Age at onset in Huntington's disease is modified by t he autophagy pathway: implication of the V471A polymorphism in Atg7. (PubMed id 20697744)1, 4 Metzger S....Nguyen H.P. (2010)
    3. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. (PubMed id 19342671)1, 2 Huett A....Xavier R.J. (2009)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64422 HGNC: 20962 AceView: APG3L Ensembl:ENSG00000144848 euGenes: HUgn64422
    ECgene: ATG3 Kegg: 64422 H-InvDB: ATG3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATG3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATG3 gene:
    Search GeneIP for patents involving ATG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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