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Aliases for ATG2B Gene

Aliases for ATG2B Gene

  • Autophagy Related 2B 2 3 5
  • C14orf103 3 4
  • ATG2 Autophagy Related 2 Homolog B (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 103 2
  • ATG2 Autophagy Related 2 Homolog B 3

External Ids for ATG2B Gene

Previous HGNC Symbols for ATG2B Gene

  • C14orf103

Previous GeneCards Identifiers for ATG2B Gene

  • GC14M095817
  • GC14M096747
  • GC14M076932

Summaries for ATG2B Gene

GeneCards Summary for ATG2B Gene

ATG2B (Autophagy Related 2B) is a Protein Coding gene. Diseases associated with ATG2B include Hypertrophy Of Breast. Among its related pathways are p53 Pathway (RnD). An important paralog of this gene is ATG2A.

UniProtKB/Swiss-Prot for ATG2B Gene

  • Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG2B Gene

Genomics for ATG2B Gene

Regulatory Elements for ATG2B Gene

Enhancers for ATG2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATG2B on UCSC Golden Path with GeneCards custom track

Promoters for ATG2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATG2B on UCSC Golden Path with GeneCards custom track

Genomic Location for ATG2B Gene

Chromosome:
14
Start:
96,279,202 bp from pter
End:
96,363,870 bp from pter
Size:
84,669 bases
Orientation:
Minus strand

Genomic View for ATG2B Gene

Genes around ATG2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG2B Gene

Proteins for ATG2B Gene

  • Protein details for ATG2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BY7-ATG2B_HUMAN
    Recommended name:
    Autophagy-related protein 2 homolog B
    Protein Accession:
    Q96BY7
    Secondary Accessions:
    • Q6ZRE7
    • Q96DQ3
    • Q9NW80

    Protein attributes for ATG2B Gene

    Size:
    2078 amino acids
    Molecular mass:
    232763 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB70872.1; Type=Erroneous termination; Positions=800; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC87363.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ATG2B Gene

Proteomics data for ATG2B Gene at MOPED

Post-translational modifications for ATG2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ATG2B

No data available for DME Specific Peptides for ATG2B Gene

Domains & Families for ATG2B Gene

Gene Families for ATG2B Gene

Protein Domains for ATG2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BY7

UniProtKB/Swiss-Prot:

ATG2B_HUMAN :
  • Belongs to the ATG2 family.
Family:
  • Belongs to the ATG2 family.
genes like me logo Genes that share domains with ATG2B: view

Function for ATG2B Gene

Molecular function for ATG2B Gene

UniProtKB/Swiss-Prot Function:
Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.
genes like me logo Genes that share phenotypes with ATG2B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG2B Gene

Localization for ATG2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG2B Gene

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG2B Gene COMPARTMENTS Subcellular localization image for ATG2B gene
Compartment Confidence
nucleus 4
cytosol 2
vacuole 1

Gene Ontology (GO) - Cellular Components for ATG2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0034045 pre-autophagosomal structure membrane IEA --
genes like me logo Genes that share ontologies with ATG2B: view

Pathways & Interactions for ATG2B Gene

SuperPathways for ATG2B Gene

Superpath Contained pathways
1 p53 Pathway (RnD)
genes like me logo Genes that share pathways with ATG2B: view

Pathways by source for ATG2B Gene

1 R&D Systems pathway for ATG2B Gene

Gene Ontology (GO) - Biological Process for ATG2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IBA --
genes like me logo Genes that share ontologies with ATG2B: view

No data available for SIGNOR curated interactions for ATG2B Gene

Drugs & Compounds for ATG2B Gene

No Compound Related Data Available

Transcripts for ATG2B Gene

Unigene Clusters for ATG2B Gene

Autophagy related 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ATG2B Gene

No ASD Table

Relevant External Links for ATG2B Gene

GeneLoc Exon Structure for
ATG2B
ECgene alternative splicing isoforms for
ATG2B

Expression for ATG2B Gene

mRNA expression in normal human tissues for ATG2B Gene

Protein differential expression in normal tissues from HIPED for ATG2B Gene

This gene is overexpressed in Fetal Brain (12.0), Bone marrow mesenchymal stem cell (10.0), Frontal cortex (9.4), Retina (8.6), and Pancreas (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG2B Gene



SOURCE GeneReport for Unigene cluster for ATG2B Gene Hs.168241

genes like me logo Genes that share expression patterns with ATG2B: view

Protein tissue co-expression partners for ATG2B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATG2B Gene

Orthologs for ATG2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATG2B 35
  • 90.38 (n)
  • 93.6 (a)
ATG2B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG2B 35
  • 91.13 (n)
  • 93.93 (a)
ATG2B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg2b 35
  • 85.69 (n)
  • 91.13 (a)
Atg2b 16
Atg2b 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATG2B 35
  • 99.6 (n)
  • 99.47 (a)
ATG2B 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATG2B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG2B 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG2B 35
  • 78.8 (n)
  • 83.57 (a)
ATG2B 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG2B 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg2b 35
  • 71.22 (n)
  • 75.13 (a)
Str.8303 35
zebrafish
(Danio rerio)
Actinopterygii ATG2B 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004092 35
  • 46.99 (n)
  • 37.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atg2 35
  • 45.03 (n)
  • 34.07 (a)
Atg2 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-2 36
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG2 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1201 36
  • 35 (a)
OneToMany
Species with no ortholog for ATG2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG2B Gene

ENSEMBL:
Gene Tree for ATG2B (if available)
TreeFam:
Gene Tree for ATG2B (if available)

Paralogs for ATG2B Gene

Paralogs for ATG2B Gene

(1) SIMAP similar genes for ATG2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATG2B: view

Variants for ATG2B Gene

Sequence variations from dbSNP and Humsavar for ATG2B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3759601 - 96,311,131(-) CCTTT(C/G)AAAGA nc-transcript-variant, reference, missense
rs2289622 - 96,305,622(+) GGACT(A/C/G)TTCCA nc-transcript-variant, reference, missense
rs9323945 - 96,315,575(+) TCCAT(C/T)CACTA nc-transcript-variant, reference, missense
rs1280492 -- 96,297,649(+) gcctc(A/G)gcctc intron-variant
rs1280493 -- 96,298,246(+) gcatc(C/T)cagct intron-variant

Variation tolerance for ATG2B Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG2B Gene

Human Gene Mutation Database (HGMD)
ATG2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATG2B Gene

Disorders for ATG2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ATG2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypertrophy of breast
  • breasts enlarged
- elite association - COSMIC cancer census association via MalaCards
Search ATG2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for ATG2B

Genetic Association Database (GAD)
ATG2B
Human Genome Epidemiology (HuGE) Navigator
ATG2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG2B
genes like me logo Genes that share disorders with ATG2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ATG2B Gene

Publications for ATG2B Gene

  1. Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. (PMID: 22219374) Velikkakath A.K. … Mizushima N. (Mol. Biol. Cell 2012) 3 4 67
  2. miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. (PMID: 22350415) Kovaleva V. … Seiffert M. (Cancer Res. 2012) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. miR-143 inhibits cell proliferation by targeting autophagy-related 2B in non-small cell lung cancer H1299 cells. (PMID: 25322940) Wei J. … Jin Y. (Mol Med Rep 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for ATG2B Gene

Sources for ATG2B Gene

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