ATG2B Gene
protein-coding GIFtS: 43
GCID: GC14M096747
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autophagy related 2B(Previous names: chromosome 14 open reading frame 103, ATG2 autophagy related...)
(Previous symbol: C14orf103)
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Aliases
for ATG2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Autophagy Related 2B1 2 | | Chromosome 14 Open Reading Frame 1031 | | C14orf1031 2 3 | | ATG2 Autophagy Related 2 Homolog B2 | | FLJ102421 | | Autophagy-Related Protein 2 Homolog B2 | | ATG2 Autophagy Related 2 Homolog B (S. Cerevisiae)1 | | |
Export aliases for ATG2B gene to outside databasesPrevious GC identifers: GC14M095817 GC14M076932 |
Summaries
for ATG2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ATG2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATG2B gene promoter:
GR HSF1 (long) FOXL1 FOXO4 COMP1 HSF1short Sox9 GR-alpha LyF-1 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATG2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.31ATG2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M096747: view genomic region
(about GC identifiers)
Start:
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96,747,595 bp from pter |
End:
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96,830,207 bp from pter |
Size:
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82,613 bases |
Orientation:
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minus strand |
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Proteins
for ATG2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATG2B_HUMAN, Q96BY7 (See
protein sequence)Recommended Name: Autophagy-related protein 2 homolog B Size: 2078 amino acids; 232763 Da
Sequence caution: Sequence=BAA91504.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB70872.1; Type=Erroneous termination; Positions=800; Note=Translated as Glu; Sequence=BAC87363.1;Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6ZRE7 Q96DQ3 Q9NW80Explore the universe of human proteins at neXtProt for ATG2B: NX_Q96BY7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96BY7
ATG2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060506.5
ENSEMBL proteins: ENSP00000353010
Human Recombinant Protein Products:
ATG2B Antibody Products:
Assay Products for ATG2B: |
Protein
Domains /
Families
for ATG2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATG2B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96BY7ProtoNet protein and cluster: Q96BY7 UniProtKB/Swiss-Prot: ATG2B_HUMAN, Q96BY7Similarity: Belongs to the ATG2 family |
Function
for ATG2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ATG2B (NM_018036) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATG2B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG2B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG2B |
|
Pathways & Interactions
for ATG2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG2B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for ATG2B (Q96BY73 ENSP000003530104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006914 | autophagy |
IEA | -- |
ATG2B for ontologies About GeneDecksing
|
Drugs & Compounds
for ATG2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ATG2B
Search CenterWatch for drugs/clinical trials and news about ATG2B
|
Transcripts
for ATG2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATG2B gene: NM_018036.5 Unigene Cluster for ATG2B: Autophagy related 2B Hs.168241 [show with all ESTs]Unigene Representative Sequence: NM_0180367 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359933(uc001yfi.3) ENST00000555263 ENST00000261834 ENST00000553643
ENST00000554151 ENST00000473234 ENST00000488421
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ATG2B (NM_018036) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATG2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG2B |
Additional cDNA sequence: AK001104.1 AK055200.1 AK123451.1 AK128275.1 AK302641.1 AL133095.1 BC015016.2 BC015851.1 3 DOTS entries: DT.208671 DT.210601 DT.101957710 24/174 AceView cDNA sequences (see all 174): AA983768 AI560009 AA904877 BM704302 BI467243 AK001104 AW444725 BC015016 AK128275 AI094178 BE047250 AA677746 CK819322 AW963994 CA425557 AW511077 BM661875 BM128371 AI079350 NM_018036 AA644603 AA262490 BM722242 AA463258
GeneLoc Exon Structure
|
Expression
for ATG2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATG2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTATTGACT
About this image
See ATG2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATG2B
SOURCE GeneReport for Unigene cluster: Hs.168241
SABiosciences Custom PCR Arrays for ATG2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATG2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG2B |
Orthologs
for ATG2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ATG2B gene from 8/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Atg2b1 , 5 |
ATG2 autophagy related 2 homolog B (S. cerevisiae)5
autophagy related 2B1 |
85.69(n)1
91.13(a)1 |
|
12 (55.82 cM)5
765591 NM_029654.41 NP_083930.51
1056135395 |
chicken
(Gallus gallus) |
Aves |
ATG2B1 |
autophagy related 2B |
78.8(n)
83.57(a) |
|
423441 XM_421350.3 XP_421350.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ATG2B6 |
-- |
82(a) |
1 ↔ 1 |
1(7778248-7837893) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.83032 |
Transcribed sequence with moderate similarity to protein more |
78.05(n) |
|
CF226038.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Atg21 |
Autophagy-specific gene 2 |
44.72(n)
33.7(a) |
|
38344 NM_139491.1 NP_647748.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
atg-21 |
Protein ATG-2 |
41.4(n)
26.23(a) |
|
180949 NM_076744.5 NP_509145.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATG26 |
protein autophagy 2 |
16(a) |
1 → many |
3(6639711-6648857) |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
14(a) |
1 → many |
6(8889919-8902223) |
ENSEMBL Gene Tree for ATG2B (if available)
TreeFam Gene Tree for ATG2B (if available) |
Paralogs
for ATG2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATG2B gene
- ATG2A2
1 SIMAP similar gene for ATG2B using alignment to 2 protein entries: ATG2B_HUMAN (see all proteins):ATG2A
ATG2B for paralogs About GeneDecksing
|
Genomic Variants
for ATG2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATG2B (96747595 - 96830207 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATG2B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG2B |
|
Disorders
/ Diseases
for ATG2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATG2B for disorders About GeneDecksing
2  diseases for ATG2B: About MalaCardscolorectal cancer neuronitis
Human Genome Epidemiology (HuGE) Navigator: ATG2B (1 document)
Export disorders for ATG2B gene to outside databases
|
Publications
for ATG2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATG2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ATG2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- miRNA-130a targets ATG2B and DICER1 to inhibit autopha gy and trigger killing of chronic lymphocytic leukemia cells. (PubMed id 22350415)1, 3 Kovaleva V....Seiffert M. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Mammalian Atg2 proteins are essential for autophagosom e formation and important for regulation of size and distribution of lipid dropl ets. (PubMed id 22219374)1 Velikkakath A.K....Mizushima N. (2012)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. (PubMed id 19197948)1 Kang M.R....Lee S.H. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Bridging expressed sequence alignments through targeted cDNA sequencing. (PubMed id 15028280)1 Xie H....Gill-More R. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ATG2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ATG2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATG2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATG2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATG2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ATG2B gene:
Search GeneIP for patents involving ATG2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATG2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ATG2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG2B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ATG2B | | OriGene 3'-UTR Clone for ATG2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ATG2B | | OriGene Custom Protein Services for ATG2B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATG2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG2B |
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 | | | ATG2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG2B |
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