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Aliases for ATG2B Gene

Aliases for ATG2B Gene

  • Autophagy Related 2B 2 3
  • C14orf103 3 4
  • ATG2 Autophagy Related 2 Homolog B (S. Cerevisiae) 2
  • Autophagy-Related Protein 2 Homolog B 3
  • Chromosome 14 Open Reading Frame 103 2
  • ATG2 Autophagy Related 2 Homolog B 3

External Ids for ATG2B Gene

Previous HGNC Symbols for ATG2B Gene

  • C14orf103

Previous GeneCards Identifiers for ATG2B Gene

  • GC14M095817
  • GC14M096747
  • GC14M076932

Summaries for ATG2B Gene

GeneCards Summary for ATG2B Gene

ATG2B (Autophagy Related 2B) is a Protein Coding gene. An important paralog of this gene is ATG2A.

UniProtKB/Swiss-Prot for ATG2B Gene

  • Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG2B Gene

Genomics for ATG2B Gene

Regulatory Elements for ATG2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATG2B Gene

96,281,258 bp from pter
96,363,870 bp from pter
82,613 bases
Minus strand

Genomic View for ATG2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG2B Gene

Proteins for ATG2B Gene

  • Protein details for ATG2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Autophagy-related protein 2 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q6ZRE7
    • Q96DQ3
    • Q9NW80

    Protein attributes for ATG2B Gene

    2078 amino acids
    Molecular mass:
    232763 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB70872.1; Type=Erroneous termination; Positions=800; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC87363.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ATG2B Gene

Proteomics data for ATG2B Gene at MOPED

Post-translational modifications for ATG2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATG2B Gene

Domains for ATG2B Gene

Protein Domains for ATG2B Gene

Suggested Antigen Peptide Sequences for ATG2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96BY7
  • Belongs to the ATG2 family.
genes like me logo Genes that share domains with ATG2B: view

No data available for Gene Families for ATG2B Gene

Function for ATG2B Gene

Molecular function for ATG2B Gene

UniProtKB/Swiss-Prot Function:
Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

Animal Model Products

CRISPR Products

miRNA for ATG2B Gene

miRTarBase miRNAs that target ATG2B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATG2B Gene

Localization for ATG2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG2B Gene

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet.

Subcellular locations from

Jensen Localization Image for ATG2B Gene COMPARTMENTS Subcellular localization image for ATG2B gene
Compartment Confidence
cytosol 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ATG2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005811 lipid particle IEA --
GO:0019898 extrinsic component of membrane IBA --
GO:0034045 pre-autophagosomal structure membrane IEA --
genes like me logo Genes that share ontologies with ATG2B: view

Pathways for ATG2B Gene

SuperPathways for ATG2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATG2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0000422 mitochondrion degradation IBA --
GO:0006995 cellular response to nitrogen starvation IBA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with ATG2B: view

No data available for Pathways by source for ATG2B Gene

Transcripts for ATG2B Gene

Unigene Clusters for ATG2B Gene

Autophagy related 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG2B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG2B Gene

No ASD Table

Relevant External Links for ATG2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG2B Gene

mRNA expression in normal human tissues for ATG2B Gene

Protein differential expression in normal tissues for ATG2B Gene

This gene is overexpressed in Fetal Brain (12.0), Bone marrow mesenchymal stem cell (10.0), Frontal cortex (9.4), Retina (8.6), and Pancreas (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG2B Gene

SOURCE GeneReport for Unigene cluster for ATG2B Gene Hs.168241

genes like me logo Genes that share expressions with ATG2B: view

Expression partners for ATG2B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATG2B Gene

Orthologs for ATG2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ATG2B 35
  • 90.38 (n)
  • 93.6 (a)
ATG2B 36
  • 93 (a)
(Canis familiaris)
Mammalia ATG2B 35
  • 91.13 (n)
  • 93.93 (a)
ATG2B 36
  • 94 (a)
(Mus musculus)
Mammalia Atg2b 35
  • 85.69 (n)
  • 91.13 (a)
Atg2b 16
Atg2b 36
  • 91 (a)
(Pan troglodytes)
Mammalia ATG2B 35
  • 99.6 (n)
  • 99.47 (a)
ATG2B 36
  • 99 (a)
(Monodelphis domestica)
Mammalia ATG2B 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ATG2B 36
  • 86 (a)
(Gallus gallus)
Aves ATG2B 35
  • 78.8 (n)
  • 83.57 (a)
ATG2B 36
  • 81 (a)
(Anolis carolinensis)
Reptilia ATG2B 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atg2b 35
  • 71.22 (n)
  • 75.13 (a)
Str.8303 35
(Danio rerio)
Actinopterygii ATG2B 36
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004092 35
  • 46.99 (n)
  • 37.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atg2 35
  • 45.03 (n)
  • 34.07 (a)
Atg2 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea atg-2 36
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG2 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1201 36
  • 35 (a)
Species with no ortholog for ATG2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG2B Gene

Gene Tree for ATG2B (if available)
Gene Tree for ATG2B (if available)

Paralogs for ATG2B Gene

Paralogs for ATG2B Gene

Selected SIMAP similar genes for ATG2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ATG2B: view

Variants for ATG2B Gene

Sequence variations from dbSNP and Humsavar for ATG2B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs972726 -- 96,302,896(+) AAATA(A/G)TTTTT intron-variant
rs1280492 -- 96,297,649(+) gcctc(A/G)gcctc intron-variant
rs1280493 -- 96,298,246(+) gcatc(C/T)cagct intron-variant
rs1280494 -- 96,299,032(+) TAAAA(G/T)AATTC intron-variant
rs1280495 -- 96,299,581(+) ATGGA(C/T)AATAG intron-variant

Relevant External Links for ATG2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATG2B Gene

Disorders for ATG2B Gene

Relevant External Links for ATG2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ATG2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ATG2B Gene

Publications for ATG2B Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. (PMID: 19197948) Kang M.R. … Lee S.H. (J. Pathol. 2009) 3 48
  5. Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. (PMID: 22219374) Velikkakath A.K. … Mizushima N. (Mol. Biol. Cell 2012) 3 4

Products for ATG2B Gene

Sources for ATG2B Gene

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