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Aliases for ATG2A Gene

Aliases for ATG2A Gene

  • Autophagy Related 2A 2 3 5
  • ATG2 Autophagy Related 2 Homolog A (S. Cerevisiae) 2
  • KIAA0404 4

External Ids for ATG2A Gene

Previous GeneCards Identifiers for ATG2A Gene

  • GC11M064430
  • GC11M064431
  • GC11M064434
  • GC11M064662
  • GC11M060989
  • GC11M064897
  • GC11M064908
  • GC11M064916
  • GC11M064922

Summaries for ATG2A Gene

GeneCards Summary for ATG2A Gene

ATG2A (Autophagy Related 2A) is a Protein Coding gene. An important paralog of this gene is ATG2B.

UniProtKB/Swiss-Prot for ATG2A Gene

  • Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG2A Gene

Genomics for ATG2A Gene

Regulatory Elements for ATG2A Gene

Enhancers for ATG2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F064354 1.4 FANTOM5 ENCODE 10.3 +559.3 559276 6.6 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A ZNF207 ZNF143 FOS PLCB3 LOC102723878 ZFPL1 ENSG00000257086 POLA2 VPS51 ATG2A CDC42BPG MRPL49 SNX15
GH11F064237 1.4 Ensembl ENCODE 10.3 +671.9 671932 16.6 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC SSRP1 TRPT1 PPP1R14B LOC102723878 VEGFB ENSG00000257086 MRPL49 TRMT112 KCNK4 ZFPL1 PLCB3
GH11F065851 1.2 ENCODE 10.3 -940.2 -940235 12.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SNX32 EIF1AD ZFPL1 PCNX3 POLA2 MRPL11 FRMD8 ENSG00000258297 NEAT1 ENSG00000255320
GH11F064267 1.2 ENCODE 10.3 +646.6 646551 7.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZFPL1 TRMT112 PLCB3 POLA2 LOC102723878 FAU MRPL49 TRPT1 ENSG00000257086 C11orf84
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATG2A on UCSC Golden Path with GeneCards custom track

Promoters for ATG2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000563722 -150 2001 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143

Genomic Location for ATG2A Gene

64,894,532 bp from pter
64,917,250 bp from pter
22,719 bases
Minus strand

Genomic View for ATG2A Gene

Genes around ATG2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG2A Gene

Proteins for ATG2A Gene

  • Protein details for ATG2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Autophagy-related protein 2 homolog A
    Protein Accession:
    Secondary Accessions:
    • O43154
    • Q14DM2
    • Q6ZTV2
    • Q7Z6K8
    • Q8IVY5
    • Q8TAI8
    • Q96HH7

    Protein attributes for ATG2A Gene

    1938 amino acids
    Molecular mass:
    212860 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA23700.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG2A Gene


neXtProt entry for ATG2A Gene

Post-translational modifications for ATG2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATG2A Gene

Domains & Families for ATG2A Gene

Gene Families for ATG2A Gene

Suggested Antigen Peptide Sequences for ATG2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATG2 family.
  • Belongs to the ATG2 family.
genes like me logo Genes that share domains with ATG2A: view

Function for ATG2A Gene

Molecular function for ATG2A Gene

UniProtKB/Swiss-Prot Function:
Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

Gene Ontology (GO) - Molecular Function for ATG2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with ATG2A: view

Phenotypes for ATG2A Gene

genes like me logo Genes that share phenotypes with ATG2A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ATG2A

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG2A Gene

Localization for ATG2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG2A Gene

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG2A gene
Compartment Confidence
nucleus 5
cytosol 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ATG2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005811 lipid particle IEA --
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IBA --
GO:0034045 pre-autophagosomal structure membrane IEA --
genes like me logo Genes that share ontologies with ATG2A: view

Pathways & Interactions for ATG2A Gene

SuperPathways for ATG2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATG2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 mitophagy IBA --
GO:0006914 autophagy IEA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with ATG2A: view

No data available for Pathways by source and SIGNOR curated interactions for ATG2A Gene

Transcripts for ATG2A Gene

Unigene Clusters for ATG2A Gene

Autophagy related 2A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ATG2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG2A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
SP5: -

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35

Relevant External Links for ATG2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ATG2A Gene

mRNA differential expression in normal tissues according to GTEx for ATG2A Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for ATG2A Gene

This gene is overexpressed in Liver, secretome (23.2), CD4 Tcells (11.9), Breast (6.7), Brain (6.7), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATG2A Gene

NURSA nuclear receptor signaling pathways regulating expression of ATG2A Gene:


SOURCE GeneReport for Unigene cluster for ATG2A Gene:

genes like me logo Genes that share expression patterns with ATG2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ATG2A Gene

Orthologs for ATG2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATG2A 34 35
  • 99.5 (n)
(Canis familiaris)
Mammalia ATG2A 34 35
  • 88.39 (n)
(Bos Taurus)
Mammalia ATG2A 34 35
  • 87.01 (n)
(Mus musculus)
Mammalia Atg2a 34 16 35
  • 84.1 (n)
(Rattus norvegicus)
Mammalia Atg2a 34
  • 83.7 (n)
(Ornithorhynchus anatinus)
Mammalia ATG2A 35
  • 49 (a)
(Anolis carolinensis)
Reptilia ATG2A 35
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atg2a 34
  • 60.77 (n)
(Danio rerio)
Actinopterygii ATG2A 35
  • 66 (a)
LOC101883461 34
  • 58.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta Atg2 35
  • 25 (a)
(Caenorhabditis elegans)
Secernentea atg-2 34 35
  • 40.76 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG2 35
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1201 35
  • 37 (a)
Species where no ortholog for ATG2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG2A Gene

Gene Tree for ATG2A (if available)
Gene Tree for ATG2A (if available)

Paralogs for ATG2A Gene

Paralogs for ATG2A Gene

(1) SIMAP similar genes for ATG2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATG2A: view

Variants for ATG2A Gene

Sequence variations from dbSNP and Humsavar for ATG2A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111535617 -- 64,912,857(+) CAAAG(G/T)GCTGG intron-variant
rs111539697 -- 64,908,483(+) GGAGG(C/T)GGAGG intron-variant
rs111792976 -- 64,896,912(+) CAGAG(A/C)CACAC intron-variant
rs111794428 -- 64,904,552(+) AAAAA(A/T)AAATA intron-variant
rs111846806 -- 64,908,034(+) TAGCC(A/G)TACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG2A Gene

Variant ID Type Subtype PubMed ID
nsv951014 CNV deletion 24416366
nsv555209 CNV loss 21841781
nsv555208 CNV loss 21841781
nsv528506 CNV loss 19592680
nsv526181 CNV gain 19592680

Variation tolerance for ATG2A Gene

Residual Variation Intolerance Score: 9.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG2A Gene

Disorders for ATG2A Gene

Relevant External Links for ATG2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATG2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG2A Gene

Publications for ATG2A Gene

  1. Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Delta strain. (PMID: 21887408) Romanyuk D. … Zoladek T. (Acta Biochim. Pol. 2011) 2 3 4 64
  2. Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. (PMID: 22219374) Velikkakath A.K. … Mizushima N. (Mol. Biol. Cell 2012) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ATG2A Gene

Sources for ATG2A Gene

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