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Aliases for ATG2A Gene

Aliases for ATG2A Gene

  • Autophagy Related 2A 2 3 5
  • ATG2 Autophagy Related 2 Homolog A (S. Cerevisiae) 2
  • KIAA0404 4

External Ids for ATG2A Gene

Previous GeneCards Identifiers for ATG2A Gene

  • GC11M064430
  • GC11M064431
  • GC11M064434
  • GC11M064662
  • GC11M060989
  • GC11M064897
  • GC11M064908
  • GC11M064916
  • GC11M064922
  • GC11M064925
  • GC11M064931

Summaries for ATG2A Gene

GeneCards Summary for ATG2A Gene

ATG2A (Autophagy Related 2A) is a Protein Coding gene. Among its related pathways are Autophagy Pathway and Autophagy - animal. An important paralog of this gene is ATG2B.

UniProtKB/Swiss-Prot for ATG2A Gene

  • Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

Additional gene information for ATG2A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG2A Gene

Genomics for ATG2A Gene

Regulatory Elements for ATG2A Gene

Enhancers for ATG2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 28.1 -572.8 -572834 39 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -506.9 -506932 18 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SF1 LOC105369352 ZFPL1 KAT5 SART1 MUS81 EIF1AD PCNX3 POLA2 SF3B2
GH11H064331 1.6 Ensembl ENCODE dbSUPER 17.7 +585.4 585358 1 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF207 ZNF143 FOS MCM3 SF1 POLA2 PLCB3 ZFPL1 ENSG00000257086 FAU ATG2A ZNHIT2 NAALADL1 IMMP1LP1
GH11H065851 1.4 ENCODE dbSUPER 18.3 -940.2 -940235 12 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC SART1 ENSG00000258297 RBM14 EIF1AD KAT5 POLA2 PCNX3 ZFPL1 SF3B2 SNX32
GH11H064884 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +31.5 31450 1 FOXA2 ATF1 MLX ARNT ARID4B DMAP1 TCF12 ZNF766 GATA2 ELK1 ATG2A EHD1 PCNX3 SF1 CDC42BPG TIGD3 RASGRP2 MAP4K2 PYGM RPS16P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATG2A on UCSC Golden Path with GeneCards custom track

Promoters for ATG2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040747 50 1601 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143

Genomic Location for ATG2A Gene

Chromosome:
11
Start:
64,894,532 bp from pter
End:
64,917,250 bp from pter
Size:
22,719 bases
Orientation:
Minus strand

Genomic View for ATG2A Gene

Genes around ATG2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG2A Gene

Proteins for ATG2A Gene

  • Protein details for ATG2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAZ0-ATG2A_HUMAN
    Recommended name:
    Autophagy-related protein 2 homolog A
    Protein Accession:
    Q2TAZ0
    Secondary Accessions:
    • O43154
    • Q14DM2
    • Q6ZTV2
    • Q7Z6K8
    • Q8IVY5
    • Q8TAI8
    • Q96HH7

    Protein attributes for ATG2A Gene

    Size:
    1938 amino acids
    Molecular mass:
    212860 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA23700.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG2A Gene

Post-translational modifications for ATG2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATG2A Gene

Domains & Families for ATG2A Gene

Gene Families for ATG2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ATG2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TAZ0

UniProtKB/Swiss-Prot:

ATG2A_HUMAN :
  • Belongs to the ATG2 family.
Family:
  • Belongs to the ATG2 family.
genes like me logo Genes that share domains with ATG2A: view

Function for ATG2A Gene

Molecular function for ATG2A Gene

UniProtKB/Swiss-Prot Function:
Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

Phenotypes From GWAS Catalog for ATG2A Gene

Gene Ontology (GO) - Molecular Function for ATG2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with ATG2A: view

Phenotypes for ATG2A Gene

genes like me logo Genes that share phenotypes with ATG2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ATG2A
  • Applied Biological Materials Clones for ATG2A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG2A Gene

Localization for ATG2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG2A Gene

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG2A gene
Compartment Confidence
nucleus 5
cytosol 5
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ATG2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005634 nucleus IDA --
GO:0005811 lipid particle IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ATG2A: view

Pathways & Interactions for ATG2A Gene

genes like me logo Genes that share pathways with ATG2A: view

Pathways by source for ATG2A Gene

2 KEGG pathways for ATG2A Gene

Gene Ontology (GO) - Biological Process for ATG2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 mitophagy IBA --
GO:0006914 autophagy IEA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with ATG2A: view

No data available for SIGNOR curated interactions for ATG2A Gene

Drugs & Compounds for ATG2A Gene

No Compound Related Data Available

Transcripts for ATG2A Gene

Unigene Clusters for ATG2A Gene

Autophagy related 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ATG2A
  • Applied Biological Materials Clones for ATG2A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ATG2A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ATG2A Gene

GeneLoc Exon Structure for
ATG2A
ECgene alternative splicing isoforms for
ATG2A

Expression for ATG2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG2A Gene

mRNA differential expression in normal tissues according to GTEx for ATG2A Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for ATG2A Gene

This gene is overexpressed in Liver, secretome (23.2), CD4 Tcells (11.9), Breast (6.7), Brain (6.7), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ATG2A Gene



NURSA nuclear receptor signaling pathways regulating expression of ATG2A Gene:

ATG2A

SOURCE GeneReport for Unigene cluster for ATG2A Gene:

Hs.370671

Evidence on tissue expression from TISSUES for ATG2A Gene

  • Liver(4.2)
  • Nervous system(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with ATG2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG2A Gene

Orthologs for ATG2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG2A 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia ATG2A 33 34
  • 88.39 (n)
cow
(Bos Taurus)
Mammalia ATG2A 33 34
  • 87.01 (n)
mouse
(Mus musculus)
Mammalia Atg2a 33 16 34
  • 84.1 (n)
rat
(Rattus norvegicus)
Mammalia Atg2a 33
  • 83.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATG2A 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG2A 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg2a 33
  • 60.77 (n)
zebrafish
(Danio rerio)
Actinopterygii ATG2A 34
  • 66 (a)
OneToOne
LOC101883461 33
  • 58.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta Atg2 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-2 33 34
  • 40.76 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG2 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1201 34
  • 37 (a)
OneToMany
Species where no ortholog for ATG2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG2A Gene

ENSEMBL:
Gene Tree for ATG2A (if available)
TreeFam:
Gene Tree for ATG2A (if available)

Paralogs for ATG2A Gene

Paralogs for ATG2A Gene

(1) SIMAP similar genes for ATG2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATG2A: view

Variants for ATG2A Gene

Sequence variations from dbSNP and Humsavar for ATG2A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000041199 -- 64,918,129(+) TTATA(C/T)ATAAC intron-variant, upstream-variant-2KB
rs1000132720 -- 64,900,722(+) CCCCC(A/G)CTAGC intron-variant
rs1000497536 -- 64,917,806(+) TAAGG(A/G)CTCTG intron-variant, upstream-variant-2KB
rs1000775364 -- 64,916,809(+) AAGAG(A/G/T)CCAGC intron-variant, upstream-variant-2KB
rs1000847365 -- 64,896,141(+) CTCTG(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG2A Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680
nsv528506 CNV loss 19592680
nsv555208 CNV loss 21841781
nsv555209 CNV loss 21841781
nsv951014 CNV deletion 24416366

Variation tolerance for ATG2A Gene

Residual Variation Intolerance Score: 9.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.15; 87.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG2A Gene

Disorders for ATG2A Gene

Relevant External Links for ATG2A

Genetic Association Database (GAD)
ATG2A
Human Genome Epidemiology (HuGE) Navigator
ATG2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG2A

No disorders were found for ATG2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG2A Gene

Publications for ATG2A Gene

  1. Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Δ strain. (PMID: 21887408) Romanyuk D … Żołądek T (Acta biochimica Polonica 2011) 2 3 4 60
  2. Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. (PMID: 22219374) Velikkakath AK … Mizushima N (Molecular biology of the cell 2012) 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ATG2A Gene

  • Addgene plasmids for ATG2A

Sources for ATG2A Gene

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