Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ATG2A Gene

Aliases for ATG2A Gene

  • Autophagy Related 2A 2 3
  • ATG2 Autophagy Related 2 Homolog A (S. Cerevisiae) 2
  • KIAA0404 4

External Ids for ATG2A Gene

Previous GeneCards Identifiers for ATG2A Gene

  • GC11M064430
  • GC11M064431
  • GC11M064434
  • GC11M064662
  • GC11M060989

Summaries for ATG2A Gene

GeneCards Summary for ATG2A Gene

ATG2A (Autophagy Related 2A) is a Protein Coding gene. An important paralog of this gene is ATG2B.

UniProtKB/Swiss-Prot for ATG2A Gene

  • Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG2A Gene

Genomics for ATG2A Gene

Regulatory Elements for ATG2A Gene

Genomic Location for ATG2A Gene

64,894,532 bp from pter
64,917,250 bp from pter
22,719 bases
Minus strand

Genomic View for ATG2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG2A Gene

Proteins for ATG2A Gene

  • Protein details for ATG2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Autophagy-related protein 2 homolog A
    Protein Accession:
    Secondary Accessions:
    • O43154
    • Q14DM2
    • Q6ZTV2
    • Q7Z6K8
    • Q8IVY5
    • Q8TAI8
    • Q96HH7

    Protein attributes for ATG2A Gene

    1938 amino acids
    Molecular mass:
    212860 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA23700.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG2A Gene


neXtProt entry for ATG2A Gene

Proteomics data for ATG2A Gene at MOPED

Post-translational modifications for ATG2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATG2A Gene

Domains for ATG2A Gene

Protein Domains for ATG2A Gene

Suggested Antigen Peptide Sequences for ATG2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q2TAZ0
  • Belongs to the ATG2 family.
genes like me logo Genes that share domains with ATG2A: view

No data available for Gene Families for ATG2A Gene

Function for ATG2A Gene

Molecular function for ATG2A Gene

UniProtKB/Swiss-Prot Function: Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

Gene Ontology (GO) - Molecular Function for ATG2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with ATG2A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATG2A Gene

Localization for ATG2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG2A Gene

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet.

Subcellular locations from

Jensen Localization Image for ATG2A Gene COMPARTMENTS Subcellular localization image for ATG2A gene
Compartment Confidence
cytosol 3
nucleus 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ATG2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005811 lipid particle IEA --
GO:0019898 extrinsic component of membrane IBA --
GO:0034045 pre-autophagosomal structure membrane IEA --
genes like me logo Genes that share ontologies with ATG2A: view

Pathways for ATG2A Gene

SuperPathways for ATG2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATG2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0000422 mitochondrion degradation IBA --
GO:0006995 cellular response to nitrogen starvation IBA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with ATG2A: view

No data available for Pathways by source for ATG2A Gene

Transcripts for ATG2A Gene

Unigene Clusters for ATG2A Gene

Autophagy related 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG2A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATG2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG2A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
SP5: -

ExUns: 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b · 24c ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35

Relevant External Links for ATG2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG2A Gene

mRNA expression in normal human tissues for ATG2A Gene

mRNA differential expression in normal tissues according to GTEx for ATG2A Gene

This gene is overexpressed in Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG2A Gene

SOURCE GeneReport for Unigene cluster for ATG2A Gene Hs.370671

genes like me logo Genes that share expressions with ATG2A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ATG2A Gene

Orthologs for ATG2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ATG2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATG2A 35
  • 99.5 (n)
  • 99.74 (a)
ATG2A 36
  • 100 (a)
(Bos Taurus)
Mammalia ATG2A 35
  • 87.01 (n)
  • 86.4 (a)
ATG2A 36
  • 91 (a)
(Canis familiaris)
Mammalia ATG2A 35
  • 88.39 (n)
  • 91.07 (a)
ATG2A 36
  • 87 (a)
(Mus musculus)
Mammalia Atg2a 35
  • 84.1 (n)
  • 85.98 (a)
Atg2a 16
Atg2a 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia ATG2A 36
  • 49 (a)
(Rattus norvegicus)
Mammalia Atg2a 35
  • 83.7 (n)
  • 86.21 (a)
(Anolis carolinensis)
Reptilia ATG2A 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia atg2a 35
  • 60.77 (n)
  • 61.54 (a)
(Danio rerio)
Actinopterygii ATG2A 36
  • 66 (a)
LOC101883461 35
  • 58.18 (n)
  • 53.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta Atg2 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea atg-2 35
  • 40.76 (n)
  • 29.83 (a)
atg-2 36
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG2 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1201 36
  • 37 (a)
Species with no ortholog for ATG2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG2A Gene

Gene Tree for ATG2A (if available)
Gene Tree for ATG2A (if available)

Paralogs for ATG2A Gene

Paralogs for ATG2A Gene

Selected SIMAP similar genes for ATG2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ATG2A: view

Variants for ATG2A Gene

Sequence variations from dbSNP and Humsavar for ATG2A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs587732 -- 64,901,389(-) agcaa(A/C)atagt intron-variant
rs587746 -- 64,907,978(-) TGAAC(A/G)ACAGG intron-variant
rs588060 -- 64,895,274(-) CCCCG(C/T)CCTGC intron-variant
rs588648 -- 64,901,175(-) aaaaa(A/G)aaGTG intron-variant
rs594820 -- 64,912,935(-) AAGTG(C/G)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG2A Gene

Variant ID Type Subtype PubMed ID
nsv528506 CNV Loss 19592680
dgv1171n71 CNV Loss 21882294
dgv1173n71 CNV Loss 21882294
nsv526181 CNV Gain 19592680

Relevant External Links for ATG2A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG2A Gene

Disorders for ATG2A Gene

Relevant External Links for ATG2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ATG2A: view

No data available for UniProtKB/Swiss-Prot for ATG2A Gene

Publications for ATG2A Gene

  1. Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Delta strain. (PMID: 21887408) Romanyuk D. … Zoladek T. (Acta Biochim. Pol. 2011) 2 3 4
  2. Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. (PMID: 22219374) Velikkakath A.K. … Mizushima N. (Mol. Biol. Cell 2012) 3 4
  3. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 3

Products for ATG2A Gene

Sources for ATG2A Gene

Back to Top