ATG2A Gene
protein-coding GIFtS: 46
GCID: GC11M064662
|
|
autophagy related 2A(Previous name: ATG2 autophagy related 2 homolog A (S. cerevisiae) )
| |
Aliases
for ATG2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Autophagy Related 2A1 2 | | KIAA04041 3 | | ATG2 Autophagy Related 2 Homolog A (S. Cerevisiae)1 | | ATG2 Autophagy Related 2 Homolog A2 | | Autophagy-Related Protein 2 Homolog A2 |
Export aliases for ATG2A gene to outside databasesPrevious GC identifers: GC11M064430 GC11M064431 GC11M064434 GC11M060989 |
Summaries
for ATG2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ATG2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATG2A gene promoter:
Egr-3 TBP p53 Sp1 Nkx2-5 Ik-3 C/EBPalpha YY1 FOXC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATG2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1ATG2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M064662: view genomic region
(about GC identifiers)
Start:
|
64,662,004 bp from pter |
End:
|
64,684,722 bp from pter |
Size:
|
22,719 bases |
Orientation:
|
minus strand |
|
Proteins
for ATG2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATG2A_HUMAN, Q2TAZ0 (See
protein sequence)Recommended Name: Autophagy-related protein 2 homolog A Size: 1938 amino acids; 212860 Da
Sequence caution: Sequence=BAA23700.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O43154 Q14DM2 Q6ZTV2 Q7Z6K8 Q8IVY5 Q8TAI8 Q96HH7Alternative splicing: 4 isoforms: Q2TAZ0-1 Q2TAZ0-3 Q2TAZ0-4 Q2TAZ0-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ATG2A: NX_Q2TAZ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2TAZ0
ATG2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055919.2
ENSEMBL proteins: ENSP00000413716 ENSP00000366475 ENSP00000410522
Human Recombinant Protein Products:
ATG2A Antibody Products:
Assay Products for ATG2A: |
Protein
Domains /
Families
for ATG2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATG2A for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2TAZ0ProtoNet protein and cluster: Q2TAZ0 1 Blocks protein family: IPB006093 Oxygen oxidoreductase covalent FAD-binding site
UniProtKB/Swiss-Prot: ATG2A_HUMAN, Q2TAZ0Similarity: Belongs to the ATG2 family |
Function
for ATG2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ATG2A (NM_015104) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATG2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG2A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG2A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
ATG2A for ontologies About GeneDecksing
|
Pathways & Interactions
for ATG2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG2A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/352 Interacting proteins for ATG2A (Q2TAZ01, 3 ENSP000003664754) via UniProtKB, MINT, STRING, and/or I2D (see all 352)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006914 | autophagy |
IEA | -- |
ATG2A for ontologies About GeneDecksing
|
Drugs & Compounds
for ATG2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ATG2A
Search CenterWatch for drugs/clinical trials and news about ATG2A
|
Transcripts
for ATG2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATG2A gene: NM_015104.2 Unigene Cluster for ATG2A: Autophagy related 2A Hs.370671 [show with all ESTs]Unigene Representative Sequence: BC1106506 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000418259 ENST00000377264 ENST00000472525 ENST00000461701(uc010rnt.1)
ENST00000461955 ENST00000421419(uc001obw.3 uc001obx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ATG2A (NM_015104) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATG2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG2A |
Additional cDNA sequence: AB007864.1 AF001545.1 AK300925.1 AK307684.1 BC008593.1 BC027481.1 BC033850.1 BC053596.1 BC110650.1 BC113090.1 BC113091.1 5 DOTS entries: DT.408726 DT.120701664 DT.70104463 DT.101975828 DT.91742874 24/99 AceView cDNA sequences (see all 99): AV700614 BQ064111 BM915672 AB007864 BQ071019 BM560754 BM454673 BU951730 BF984155 BM855676 BM980863 AW339554 BC027481 CD671341 BQ057657 CB216526 BC008593 BQ066013 BE254933 BU182094 BC053596 CA432115 BM549748 BU166319
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ATG2A (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ATG2A
|
Expression
for ATG2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATG2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTGGAATA
About this image
See ATG2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATG2A
SOURCE GeneReport for Unigene cluster: Hs.370671
SABiosciences Custom PCR Arrays for ATG2A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG2A
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG2A |
Orthologs
for ATG2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ATG2A gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ATG2A6 |
-- |
58(a) |
1 ↔ 1 |
GL344659.1(148-22603) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BG815119.12 |
-- |
78.41(n) |
|
BG815119.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570915022 |
-- |
79.52(n) |
|
57091502 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Atg26 |
Autophagy-specific gene 2 |
26(a) |
1 → many |
3L(2774338-2780677) |
worm
(Caenorhabditis elegans) |
Secernentea |
atg-26 |
AuTophaGy (yeast Atg homolog) family member (atg-2... |
16(a) |
1 → many |
X(6809065-6817593) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATG26 |
protein autophagy 2 |
14(a) |
1 → many |
3(6639711-6648857) |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
14(a) |
1 → many |
6(8889919-8902223) |
ENSEMBL Gene Tree for ATG2A (if available)
TreeFam Gene Tree for ATG2A (if available) |
Paralogs
for ATG2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATG2A gene
- ATG2B2
1 SIMAP similar gene for ATG2A using alignment to 3 protein entries: ATG2A_HUMAN (see all proteins):ATG2B
ATG2A for paralogs About GeneDecksing
|
Genomic Variants
for ATG2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATG2A (64662004 - 64684722 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATG2A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG2A |
|
Disorders
/ Diseases
for ATG2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATG2A for disorders About GeneDecksing
2  diseases for ATG2A: About MalaCardsmultiple endocrine neoplasia neuronitis
Human Genome Epidemiology (HuGE) Navigator: ATG2A (1 document)
Export disorders for ATG2A gene to outside databases
|
Publications
for ATG2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATG2A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ATG2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human hAtg2A protein expressed in yeast is recruited t o preautophagosomal structure but does not complement autophagy defects of atg2D strain. (PubMed id 21887408)1, 3 Romanyuk D....Zol/adek T. (2011)
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
- Mammalian Atg2 proteins are essential for autophagosom e formation and important for regulation of size and distribution of lipid dropl ets. (PubMed id 22219374)1 Velikkakath A.K....Mizushima N. (2012)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for ATG2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ATG2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATG2A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ATG2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATG2A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ATG2A gene:
Search GeneIP for patents involving ATG2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATG2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | ATG2A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG2A |
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