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Aliases for ATG16L2 Gene

Aliases for ATG16L2 Gene

  • Autophagy Related 16 Like 2 2 3 5
  • WD Repeat-Containing Protein 80 3 4
  • APG16-Like 2 3 4
  • WDR80 3 4
  • ATG16 Autophagy Related 16-Like 2 (S. Cerevisiae) 2
  • Autophagy Related 16-Like 2 (S. Cerevisiae) 2
  • ATG16 Autophagy Related 16-Like 2 3
  • Autophagy-Related Protein 16-2 3
  • ATG16B 3

External Ids for ATG16L2 Gene

Previous GeneCards Identifiers for ATG16L2 Gene

  • GC11P072203
  • GC11P072525
  • GC11P068820

Summaries for ATG16L2 Gene

GeneCards Summary for ATG16L2 Gene

ATG16L2 (Autophagy Related 16 Like 2) is a Protein Coding gene. Among its related pathways are Autophagy - animal. An important paralog of this gene is ATG16L1.

UniProtKB/Swiss-Prot for ATG16L2 Gene

  • May play a role in autophagy.

Additional gene information for ATG16L2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG16L2 Gene

Genomics for ATG16L2 Gene

Regulatory Elements for ATG16L2 Gene

Enhancers for ATG16L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H072735 2 FANTOM5 Ensembl ENCODE dbSUPER 14.4 -74.1 -74102 10 HDGF FOXA2 PKNOX1 ATF1 GLI4 YY1 TCF12 GLIS2 GATA2 ZNF143 ARAP1 STARD10 ATG16L2 PDE2A P2RY2 FCHSD2 PIR40050 RPS12P20
GH11H072831 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.2 +19.7 19733 5.9 RB1 ZNF2 RAD21 RFX5 GLIS2 ZNF143 ATF7 CREM DEK ZNF654 ATG16L2 ARAP1 STARD10 PDE2A FCHSD2 RNU6-672P GC11M072870
GH11H072762 1.6 FANTOM5 ENCODE dbSUPER 11.7 -49.0 -48997 5.6 PKNOX1 FOXA2 MLX ARID4B DMAP1 RUNX3 SP5 MXD4 REST PPARG ARAP1 STARD10 ATG16L2 RPS12P20 ARAP1-AS2 PDE2A ARAP1-AS1 RNU6-672P GC11P072768 PIR40050
GH11H072757 1.5 Ensembl ENCODE dbSUPER 11.3 -55.4 -55436 1.9 HDGF PKNOX1 ATF1 ARNT GLI4 GLIS2 FOS ATF7 NCOA1 REST ARAP1 STARD10 RPS12P20 ARAP1-AS2 ATG16L2 ARAP1-AS1 PDE2A RNU6-672P PIR40050 GC11P072768
GH11H072771 1.3 Ensembl ENCODE dbSUPER 11.7 -40.9 -40898 3.4 JUN SIN3A ZMYM3 ZIC2 RELA FOSL1 ZNF664 HIC1 ZFHX2 POLR2A STARD10 ARAP1 ATG16L2 ENSG00000202522 MIR4692
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ATG16L2 on UCSC Golden Path with GeneCards custom track

Promoters for ATG16L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041775 -1808 201 PKNOX1 FOXA2 RFX1 BMI1

Genomic Locations for ATG16L2 Gene

Genomic Locations for ATG16L2 Gene
29,367 bases
Plus strand

Genomic View for ATG16L2 Gene

Genes around ATG16L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG16L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG16L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG16L2 Gene

Proteins for ATG16L2 Gene

  • Protein details for ATG16L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Autophagy-related protein 16-2
    Protein Accession:
    Secondary Accessions:
    • A5PL30
    • B2RPK5
    • Q658V4
    • Q6PID3
    • Q8NBG0

    Protein attributes for ATG16L2 Gene

    619 amino acids
    Molecular mass:
    68998 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ATG16L2 Gene


neXtProt entry for ATG16L2 Gene

Post-translational modifications for ATG16L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ATG16L2 Gene

Domains & Families for ATG16L2 Gene

Gene Families for ATG16L2 Gene

Suggested Antigen Peptide Sequences for ATG16L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat ATG16 family.
  • Belongs to the WD repeat ATG16 family.
genes like me logo Genes that share domains with ATG16L2: view

Function for ATG16L2 Gene

Molecular function for ATG16L2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in autophagy.

Phenotypes From GWAS Catalog for ATG16L2 Gene

Phenotypes for ATG16L2 Gene

genes like me logo Genes that share phenotypes with ATG16L2: view

Animal Model Products

miRNA for ATG16L2 Gene

miRTarBase miRNAs that target ATG16L2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG16L2 Gene

Localization for ATG16L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG16L2 Gene

Cytoplasm. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ATG16L2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ATG16L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ATG16L2: view

Pathways & Interactions for ATG16L2 Gene

SuperPathways for ATG16L2 Gene

SuperPathway Contained pathways
1 Autophagy - animal
genes like me logo Genes that share pathways with ATG16L2: view

Pathways by source for ATG16L2 Gene

1 GeneTex pathway for ATG16L2 Gene
1 KEGG pathway for ATG16L2 Gene

Gene Ontology (GO) - Biological Process for ATG16L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0006810 transport IEA --
GO:0006914 autophagy IEA --
GO:0015031 protein transport IEA --
GO:0039689 negative stranded viral RNA replication IBA,IEA --
genes like me logo Genes that share ontologies with ATG16L2: view

No data available for SIGNOR curated interactions for ATG16L2 Gene

Drugs & Compounds for ATG16L2 Gene

No Compound Related Data Available

Transcripts for ATG16L2 Gene

Unigene Clusters for ATG16L2 Gene

Autophagy related 16-like 2 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG16L2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - -
SP7: - - - - - - - - - - - - - - - - - - - -
SP8: - -
SP9: - -

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
SP7: - - - -

Relevant External Links for ATG16L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG16L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ATG16L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATG16L2 Gene

This gene is overexpressed in Whole Blood (x15.7) and Spleen (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of ATG16L2 Gene:


SOURCE GeneReport for Unigene cluster for ATG16L2 Gene:


Evidence on tissue expression from TISSUES for ATG16L2 Gene

  • Nervous system(4.5)
  • Spleen(4.4)
  • Stomach(4.3)
  • Liver(4.1)
  • Eye(4)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with ATG16L2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ATG16L2 Gene

Orthologs for ATG16L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG16L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ATG16L2 33 34
  • 98.24 (n)
(Bos Taurus)
Mammalia ATG16L2 33 34
  • 88.04 (n)
(Canis familiaris)
Mammalia ATG16L2 33 34
  • 87.11 (n)
(Mus musculus)
Mammalia Atg16l2 33 16 34
  • 85.5 (n)
(Rattus norvegicus)
Mammalia Atg16l2 33
  • 84.9 (n)
(Ornithorhynchus anatinus)
Mammalia ATG16L2 34
  • 70 (a)
(Monodelphis domestica)
Mammalia ATG16L2 34
  • 65 (a)
(Anolis carolinensis)
Reptilia ATG16L2 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485143 33
  • 55.18 (n)
(Danio rerio)
Actinopterygii LOC100007282 33
  • 61.58 (n)
ATG16L2 (2 of 2) 34
  • 59 (a)
atg16l2 34
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31033 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea atg-16.2 34
  • 26 (a)
atg-16.1 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for ATG16L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG16L2 Gene

Gene Tree for ATG16L2 (if available)
Gene Tree for ATG16L2 (if available)

Paralogs for ATG16L2 Gene

Paralogs for ATG16L2 Gene

genes like me logo Genes that share paralogs with ATG16L2: view

Variants for ATG16L2 Gene

Sequence variations from dbSNP and Humsavar for ATG16L2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000091446 -- 72,839,645(+) GATGG(A/G)GGTTC intron-variant
rs1000148970 -- 72,843,657(+) ATAAA(A/C)ATTTA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000215235 -- 72,844,021(+) CAAAC(-/AAAA)AAAGA intron-variant, downstream-variant-500B
rs1000486286 -- 72,818,897(+) AAATG(C/T)GGGCA intron-variant
rs1000698528 -- 72,838,160(+) TAATA(C/T)GAAGG intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATG16L2 Gene

Variant ID Type Subtype PubMed ID
nsv951039 CNV deletion 24416366
nsv473572 CNV novel sequence insertion 20440878

Variation tolerance for ATG16L2 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG16L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG16L2 Gene

Disorders for ATG16L2 Gene

Relevant External Links for ATG16L2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATG16L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG16L2 Gene

Publications for ATG16L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 60
  3. A functional variant of ATG16L2 is associated with Crohn's disease in the Chinese population. (PMID: 27611316) Ma T … Zhou C (Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2016) 3 60
  4. Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. (PMID: 26663301) Lessard CJ … Tsao BP (Arthritis & rheumatology (Hoboken, N.J.) 2016) 3 60
  5. FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification. (PMID: 25720964) Kourtis N … Aifantis I (Nature cell biology 2015) 3 60

Products for ATG16L2 Gene

Sources for ATG16L2 Gene

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