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Aliases for ATG16L2 Gene

Aliases for ATG16L2 Gene

  • Autophagy Related 16-Like 2 (S. Cerevisiae) 2 3
  • WD Repeat-Containing Protein 80 3 4
  • APG16-Like 2 3 4
  • WDR80 3 4
  • ATG16 Autophagy Related 16-Like 2 (S. Cerevisiae) 2
  • ATG16 Autophagy Related 16-Like 2 3
  • Autophagy-Related Protein 16-2 3
  • ATG16B 3

External Ids for ATG16L2 Gene

Previous GeneCards Identifiers for ATG16L2 Gene

  • GC11P072203
  • GC11P072525
  • GC11P068820

Summaries for ATG16L2 Gene

GeneCards Summary for ATG16L2 Gene

ATG16L2 (Autophagy Related 16-Like 2 (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Regulation of autophagy. An important paralog of this gene is ATG16L1.

UniProtKB/Swiss-Prot for ATG16L2 Gene

  • May play a role in autophagy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG16L2 Gene

Genomics for ATG16L2 Gene

Regulatory Elements for ATG16L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATG16L2 Gene

Start:
72,814,308 bp from pter
End:
72,843,674 bp from pter
Size:
29,367 bases
Orientation:
Plus strand

Genomic View for ATG16L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG16L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG16L2 Gene

Proteins for ATG16L2 Gene

  • Protein details for ATG16L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAA4-A16L2_HUMAN
    Recommended name:
    Autophagy-related protein 16-2
    Protein Accession:
    Q8NAA4
    Secondary Accessions:
    • A5PL30
    • B2RPK5
    • Q658V4
    • Q6PID3
    • Q8NBG0

    Protein attributes for ATG16L2 Gene

    Size:
    619 amino acids
    Molecular mass:
    68998 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ATG16L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG16L2 Gene

Proteomics data for ATG16L2 Gene at MOPED

Post-translational modifications for ATG16L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ATG16L2 Gene

Domains for ATG16L2 Gene

Gene Families for ATG16L2 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for ATG16L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NAA4

UniProtKB/Swiss-Prot:

A16L2_HUMAN :
  • Q8NAA4
Family:
  • Belongs to the WD repeat ATG16 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with ATG16L2: view

Function for ATG16L2 Gene

Molecular function for ATG16L2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in autophagy.

Gene Ontology (GO) - Molecular Function for ATG16L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ATG16L2: view

Phenotypes for ATG16L2 Gene

GenomeRNAi human phenotypes for ATG16L2:
genes like me logo Genes that share phenotypes with ATG16L2: view

Animal Model Products

CRISPR Products

miRNA for ATG16L2 Gene

miRTarBase miRNAs that target ATG16L2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG16L2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATG16L2 Gene

Localization for ATG16L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG16L2 Gene

Cytoplasm. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG16L2 Gene COMPARTMENTS Subcellular localization image for ATG16L2 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ATG16L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagic vacuole membrane IBA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with ATG16L2: view

Pathways for ATG16L2 Gene

SuperPathways for ATG16L2 Gene

Superpath Contained pathways
1 Regulation of autophagy
genes like me logo Genes that share pathways with ATG16L2: view

Pathways by source for ATG16L2 Gene

1 KEGG pathway for ATG16L2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ATG16L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0006914 autophagy --
GO:0015031 protein transport IEA --
GO:0039689 negative stranded viral RNA replication IBA --
genes like me logo Genes that share ontologies with ATG16L2: view

Transcripts for ATG16L2 Gene

Unigene Clusters for ATG16L2 Gene

Autophagy related 16-like 2 (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG16L2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG16L2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - - - - -
SP8: - -
SP9: - -
SP10:
SP11:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - - -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ATG16L2 Gene

GeneLoc Exon Structure for
ATG16L2
ECgene alternative splicing isoforms for
ATG16L2

Expression for ATG16L2 Gene

mRNA expression in normal human tissues for ATG16L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ATG16L2 Gene

This gene is overexpressed in Whole Blood (15.7) and Spleen (5.3).

SOURCE GeneReport for Unigene cluster for ATG16L2 Gene Hs.653186

genes like me logo Genes that share expressions with ATG16L2: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ATG16L2 Gene

Orthologs for ATG16L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG16L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATG16L2 35
  • 88.04 (n)
  • 86.2 (a)
ATG16L2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG16L2 35
  • 87.11 (n)
  • 84.5 (a)
ATG16L2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg16l2 35
  • 85.5 (n)
  • 83.77 (a)
Atg16l2 16
Atg16l2 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATG16L2 35
  • 98.24 (n)
  • 98.02 (a)
ATG16L2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg16l2 35
  • 84.9 (n)
  • 82.63 (a)
oppossum
(Monodelphis domestica)
Mammalia ATG16L2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG16L2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG16L2 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485143 35
  • 55.18 (n)
  • 44.29 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100007282 35
  • 61.58 (n)
  • 57.43 (a)
atg16l2 36
  • 28 (a)
OneToMany
ATG16L2 (2 of 2) 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31033 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atg-16.1 36
  • 23 (a)
ManyToMany
atg-16.2 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ATG16L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG16L2 Gene

ENSEMBL:
Gene Tree for ATG16L2 (if available)
TreeFam:
Gene Tree for ATG16L2 (if available)

Paralogs for ATG16L2 Gene

Paralogs for ATG16L2 Gene

genes like me logo Genes that share paralogs with ATG16L2: view

Variants for ATG16L2 Gene

Sequence variations from dbSNP and Humsavar for ATG16L2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs891655 -- 72,817,928(-) ACACA(A/C/G/T)GAGTA intron-variant
rs891657 -- 72,829,180(+) AACTT(G/T)ACAGA intron-variant
rs919600 -- 72,818,748(-) GTCAA(C/T)AGATG intron-variant
rs1126205 -- 72,812,749(-) ACTGG(A/C)GGACT upstream-variant-2KB
rs1320730 -- 72,817,678(+) GCTTT(A/T)CATGT intron-variant

Relevant External Links for ATG16L2 Gene

HapMap Linkage Disequilibrium report
ATG16L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATG16L2 Gene

Disorders for ATG16L2 Gene

Relevant External Links for ATG16L2

Genetic Association Database (GAD)
ATG16L2
Human Genome Epidemiology (HuGE) Navigator
ATG16L2

No disorders were found for ATG16L2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ATG16L2 Gene

Publications for ATG16L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for ATG16L2 Gene

Sources for ATG16L2 Gene

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