Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ATG16L2 Gene

protein-coding GIFtS: 47
GCID: GC11P072525

autophagy related 16-like 2 (S. cerevisiae)

(Previous name: ATG16 autophagy related 16-like 2 (S. cerevisiae) )

Explore 1 disease affiliated with
ATG16L2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Autophagy Related 16-Like 2 (S. Cerevisiae)¹ ²		FLJ00012¹
WDR80¹ ² ³		ATG16 Autophagy Related 16-Like 2 (S. Cerevisiae)¹
ATG16B¹ ²		ATG16 Autophagy Related 16-Like 2²
APG16-Like 2² ³		Autophagy-Related Protein 16-2²
WD Repeat-Containing Protein 80² ³

External Ids:	HGNC: 25464¹	Entrez Gene: 89849²	Ensembl: ENSG00000168010⁷	UniProtKB: Q8NAA4³

Export aliases for ATG16L2 gene to outside databases

Previous GC identifers: GC11P072203 GC11P068820

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: A16L2_HUMAN, Q8NAA4

Function: May play a role in autophagy (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ATG16L2 gene promoter:
AML1a Sp1 Meis-1a Nkx2-5 LCR-F1 Meis-1b Meis-1 RORalpha2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATG16L2 promoter sequence

Search SABiosciences Chromatin IP Primers for ATG16L2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG16L2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4

ATG16L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG16L2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P072525: view genomic region (about GC identifiers)

Start:	72,525,353 bp from pter	End:	72,554,719 bp from pter
Size:	29,367 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: A16L2_HUMAN, Q8NAA4 (See protein sequence)

Recommended Name: Autophagy-related protein 16-2

Size: 619 amino acids; 68998 Da

Subcellular location: Cytoplasm (By similarity)

Secondary accessions: A5PL30 B2RPK5 Q658V4 Q6PID3 Q8NBG0

Alternative splicing: 3 isoforms: Q8NAA4-1 Q8NAA4-2 Q8NAA4-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATG16L2: NX_Q8NAA4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NAA4

ATG16L2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_203746.1

ENSEMBL proteins:

ENSP00000326340 ENSP00000441189 ENSP00000400705 ENSP00000442635 ENSP00000443569

ENSP00000442931 ENSP00000438474 ENSP00000441989 ENSP00000437412 ENSP00000441747

ENSP00000437932 ENSP00000441132

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ATG16L2 OriGene Custom Protein Services for ATG16L2
	GenScript Custom Purified and Recombinant Proteins Services for ATG16L2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ATG16L2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

ATG16L2 for ontologies About GeneDecksing

ATG16L2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ATG16L2
	GenScript Custom Superior Antibodies Services for ATG16L2
	Novus Biologicals ATG16L2 Antibodies
	Search for Antibodies for ATG16L2 at Abcam
	Uscn Antibodies for ATG16L2
	Search ThermoFisher Antibodies for ATG16L2

Assay Products for ATG16L2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ATG16L2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ATG16L2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ATG16L2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR013923 Autophagy-rel_prot_16

IPR020472 G-protein_beta_WD-40_rep

IPR017986 WD40_repeat_dom

Graphical View of Domain Structure for InterPro Entry Q8NAA4

ProtoNet protein and cluster: Q8NAA4

2 Blocks protein families:

IPB001680 G-protein beta WD-40 repeat signature

IPB013923 Autophagy protein Apg16

UniProtKB/Swiss-Prot: A16L2_HUMAN, Q8NAA4

Similarity: Belongs to the WD repeat ATG16 family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: A16L2_HUMAN, Q8NAA4

Function: May play a role in autophagy (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: ATG16L2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATG16L2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ATG16L2:
		hsa-miR-3142
		SwitchGear 3'UTR luciferase reporter plasmid: ATG16L2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG16L2 (see all 4) OriGene shRNA RFP: ATG16L2 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG16L2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ATG16L2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG16L2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG16L2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ATG16L2 (NM_033388)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG16L2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG16L2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ATG16L2
		Search LifeMap BioReagents cell lines for ATG16L2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG16L2

2 GenomeRNAi human phenotypes for ATG16L2:

Decreased Tat-dependent transc

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ATG16L2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for ATG16L2 (Q8NAA4^{2, 3} ENSP00000326340⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TK1	P04183²^,³	MINT-8272949 I2D: score=2
ATG5	Q9H1Y0³, ENSP00000343313⁴	I2D: score=3 STRING: ENSP00000343313
MAP1LC3B	Q9GZQ8³, ENSP00000268607⁴	I2D: score=1 STRING: ENSP00000268607
GABARAP	O95166³, ENSP00000306866⁴	I2D: score=1 STRING: ENSP00000306866

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006914	autophagy	IEA	--
GO:0015031	protein transport	IEA	--

ATG16L2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ATG16L2
Search CenterWatch for drugs/clinical trials and news about ATG16L2 / A16L2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ATG16L2 gene:

NM_033388.1

Unigene Cluster for ATG16L2:

Autophagy related 16-like 2 (S. cerevisiae)

Hs.653186 [show with all ESTs]

Unigene Representative Sequence: AK024423

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000321297(uc001otd.3) ENST00000534905(uc009ytj.2) ENST00000435507(uc001ote.3)

ENST00000439504(uc010rrf.1) ENST00000537143 ENST00000542908 ENST00000544490

ENST00000540567(uc001otc.1) ENST00000451353 ENST00000538842 ENST00000536995

ENST00000537212 ENST00000541999 ENST00000535830 ENST00000538973 ENST00000541367

ENST00000545248 ENST00000540222

miRNA Products:		OriGene 3'-UTR Clone: ATG16L2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ATG16L2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ATG16L2:
		hsa-miR-3142
		SwitchGear 3'UTR luciferase reporter plasmid: ATG16L2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG16L2 (see all 4) OriGene shRNA RFP: ATG16L2 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG16L2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG16L2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG16L2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ATG16L2 (NM_033388)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG16L2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG16L2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG16L2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ATG16L2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG16L2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG16L2

Additional cDNA sequence:

AK024423.1 AK090597.1 AK091151.1 AK093017.1 AK303270.1 AL832974.1 BC036713.2 BC069189.1

BC108672.1 BC137489.1 BC137490.1 BC142718.1 BC146660.1

22 DOTS entries:

DT.95158122 DT.100784564 DT.409379 DT.95158121 DT.97844255 DT.97815839 DT.120697414 DT.75102482

DT.100784561 DT.120697518 DT.100026669 DT.92429266 DT.92429269 DT.100784558 DT.120697638 DT.75139696

DT.92009396 DT.40109449 DT.120697410 DT.314665 DT.65287842 DT.92465924

24/228 AceView cDNA sequences (see all 228):

BX280181 CR590633 BQ057865 Z41861 AL520854 CR609750 AW177814 AL524181

AK024423 AW177823 CR593047 BE705874 CB242544 BI492385 CB529375 BX452223

AW177820 BU629916 BQ962062 AA328500 BU677837 AW177903 AA330614 AW177897

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ATG16L2 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^
SP1:													-		-										-		-						-		-		-		-				-
SP2:													-		-		-								-		-						-		-		-		-				-
SP3:													-												-		-												-				-
SP4:																																	-		-		-		-				-
SP5:																																	-		-				-				-

ExUns:	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ATG16L2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ATG16L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ATG16L2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primordial germ cell-like cells (Reconstitution of mo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ATG16L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATG16L2

SOURCE GeneReport for Unigene cluster: Hs.653186

SABiosciences Expression via Pathway-Focused PCR Array including ATG16L2:

Autophagy in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG16L2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ATG16L2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG16L2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG16L2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG16L2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATG16L2 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ATG16L2⁶	--	66(a)	1 ↔ 1	GL343587.1(324707-347830)
zebrafish (Danio rerio)	Actinopterygii	LOC100007282¹	autophagy-related protein 16-2-like	61.58(n) 57.43(a)		100007282 XM_001345744.4 XP_001345780.4
fruit fly (Drosophila melanogaster)	Insecta	CG31033⁶	--	28(a)	1 → many	3R(25653003-25660823)
worm (Caenorhabditis elegans)	Secernentea	atg-16.2⁶ atg-16.1⁶	Autophagic-related protein 16.1	23(a) 22(a)	many ↔ many many ↔ many	II(6450898-6453366) X(4459609-4462584)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G50230⁶	transducin/WD40 domain-containing protein	24(a)	1 → many	5(20448370-20450881)
rice (Oryza sativa)	Liliopsida	--	WD domain, G-beta repeat domain containing protein...	21(a)	1 → many	3(30682327-30685988)

ENSEMBL Gene Tree for ATG16L2 (if available)
TreeFam Gene Tree for ATG16L2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ATG16L2 gene

POC1B² WDR83² WDR5² ATG16L1² WDR88² SNRNP40² WDR5B² KATNB1²

PAFAH1B1² PRPF4² DAW1² WDR38² POC1A² WDSUB1²

5 SIMAP similar genes for ATG16L2 using alignment to 13 protein entries: A16L2_HUMAN (see all proteins):

FLJ00012 ATG16L1 FLJ10035 FLJ00045 POC1B

ATG16L2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140291439^1,2		--	72523687(+)	`GAGAAA/GCGGCA`	1	--	us2k¹		0	--	--	--	--
rs182853389^1,2		--	72523688(+)	`AGAAAC/TGGCAT`	1	--	us2k¹		0	--	--	--	--
rs1126205^1,2	C,F,H,	--	72523794(-)	`ACTGGA/C/G/T GGACT`	1	--	us2k¹		31		NS EA MN NA WA	3522
rs145319072^1,2		--	72523970(+)	`TAGGAA/CCCAGG`	1	--	us2k¹		0	--	--	--	--
rs187882198^1,2		--	72524016(+)	`GGTGTC/GATAAC`	1	--	us2k¹		0	--	--	--	--
rs192402186^1,2		--	72524284(+)	`GCTTTC/TTACGT`	1	--	us2k¹		0	--	--	--	--
rs116530967^1,2	C,F,	--	72524298(+)	`CTGACC/ACATCC`	1	--	us2k¹		1		WA	118
rs183930380^1,2		--	72524510(+)	`TCTAGC/TATCTA`	1	--	us2k¹		0	--	--	--	--
rs187637973^1,2		--	72524734(+)	`ATGAAA/GTCAGC`	1	--	us2k¹		0	--	--	--	--
rs137892262^1,2		--	72524836(+)	`CTGGCA/GTTTTC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ATG16L2 (72525353 - 72554719 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ATG16L2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG16L2

DNA2.0 Custom Variant and Variant Library Synthesis for ATG16L2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ATG16L2 for disorders About GeneDecksing

1 disease for ATG16L2: About MalaCards

crohn's disease

Human Genome Epidemiology (HuGE) Navigator: ATG16L2 (1 document)

Export disorders for ATG16L2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ATG16L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ATG16L2)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)^{1, 3} Hattori A.... Ohara O. (2000)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 89849	HGNC: 25464	AceView: FLJ00012	Ensembl:ENSG00000168010	euGenes: HUgn89849
ECgene: ATG16L2	H-InvDB: ATG16L2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ATG16L2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ATG16L2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ATG16L2 gene:
Search GeneIP for patents involving ATG16L2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ATG16L2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG16L2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG16L2
	OriGene Protein Over-expression Lysate for ATG16L2		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for ATG16L2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG16L2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG16L2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ATG16L2		OriGene Custom Protein Services for ATG16L2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATG16L2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG16L2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG16L2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG16L2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG16L2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG16L2

	GenScript Custom Purified and Recombinant Proteins Services for ATG16L2		GenScript cDNA clones with any tag delivered in your preferred vector for ATG16L2
	GenScript Custom Assay Services for ATG16L2		GenScript Custom Superior Antibodies Services for ATG16L2
	GenScript Custom overexpressing Cell Line Services for ATG16L2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ATG16L2 promoter
	Search Chromatin IP Primers for ATG16L2
	RT² qPCR Primer Assay in human, mouse, rat ATG16L2
	Search GNC Networks for ATG16L2
	SABiosciences PCR Arrays including human, mouse, rat ATG16L2

Search Tocris compounds for ATG16L2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ATG16L2 antibodies

	Search for Antibodies for ATG16L2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ATG16L2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ATG16L2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ATG16L2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG16L2

	SwitchGear 3'UTR luciferase reporter plasmids for ATG16L2
	SwitchGear Promoter luciferase reporter plasmids for ATG16L2

Search ThermoFisher Antibodies for ATG16L2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG16L2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ATG16L2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ATG16L2 Gene

autophagy related 16-like 2 (S. cerevisiae)

Aliases
for ATG16L2 gene

Summaries
for ATG16L2 gene

Genomic Views
for ATG16L2 gene

Proteins
for ATG16L2 gene

Protein Domains /
Families
for ATG16L2 gene

Function
for ATG16L2 gene

Pathways & Interactions
for ATG16L2 gene

Drugs & Compounds
for ATG16L2 gene

Transcripts
for ATG16L2 gene

Expression
for ATG16L2 gene

Orthologs
for ATG16L2 gene

Paralogs
for ATG16L2 gene

Genomic Variants
for ATG16L2 gene

Disorders / Diseases
for ATG16L2 gene

Publications
for ATG16L2 gene

External Searches for ATG16L2 gene

Genome Databases showing ATG16L2 gene

Other Databases showing ATG16L2 gene

Specialized Databases showing ATG16L2 gene

Intellectual Property
for ATG16L2 gene

Products
for ATG16L2 gene

View Random Gene

Advanced Search

Export list of displayed genes

ATG16L2 Gene

autophagy related 16-like 2 (S. cerevisiae)

Aliasesfor ATG16L2 gene

Summariesfor ATG16L2 gene

Genomic Viewsfor ATG16L2 gene

Proteinsfor ATG16L2 gene

Protein Domains /Familiesfor ATG16L2 gene

Functionfor ATG16L2 gene

Pathways & Interactionsfor ATG16L2 gene

Drugs & Compoundsfor ATG16L2 gene

Transcriptsfor ATG16L2 gene

Expression for ATG16L2 gene

Orthologsfor ATG16L2 gene

Paralogsfor ATG16L2 gene

Genomic Variantsfor ATG16L2 gene

Disorders / Diseasesfor ATG16L2 gene

Publicationsfor ATG16L2 gene

External Searches for ATG16L2 gene

Genome Databases showing ATG16L2 gene

Other Databases showing ATG16L2 gene

Specialized Databases showing ATG16L2 gene

Intellectual Propertyfor ATG16L2 gene

Productsfor ATG16L2 gene

View Random Gene

Aliases
for ATG16L2 gene

Summaries
for ATG16L2 gene

Genomic Views
for ATG16L2 gene

Proteins
for ATG16L2 gene

Protein Domains /
Families
for ATG16L2 gene

Function
for ATG16L2 gene

Pathways & Interactions
for ATG16L2 gene

Drugs & Compounds
for ATG16L2 gene

Transcripts
for ATG16L2 gene

Expression
for ATG16L2 gene

Orthologs
for ATG16L2 gene

Paralogs
for ATG16L2 gene

Genomic Variants
for ATG16L2 gene

Disorders / Diseases
for ATG16L2 gene

Publications
for ATG16L2 gene

Intellectual Property
for ATG16L2 gene

Products
for ATG16L2 gene