Aliases for ATG16L1 Gene
External Ids for ATG16L1 Gene
Previous HGNC Symbols for ATG16L1 Gene
Previous GeneCards Identifiers for ATG16L1 Gene
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
GeneCards Summary for ATG16L1 Gene
ATG16L1 (Autophagy Related 16 Like 1) is a Protein Coding gene. Diseases associated with ATG16L1 include Inflammatory Bowel Disease 10 and Crohn's Disease. Among its related pathways are Toll-Like receptor Signaling Pathways and Cellular Senescence. GO annotations related to this gene include identical protein binding. An important paralog of this gene is ATG16L2.
UniProtKB/Swiss-Prot for ATG16L1 Gene
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.