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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATG14 Gene

protein-coding   GIFtS: 49
GCID: GC14M055834

Autophagy Related 14

(Previous names: KIAA0831, ATG14 autophagy related 14 homolog (S. cerevisiae))
(Previous symbol: KIAA0831)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Autophagy Related 141 2     ATG14L2
KIAA08311 2 3     BARKOR2
Barkor1 3     ATG14 Autophagy Related 14 Homolog2
Beclin 1-Associated Autophagy-Related Key Regulator1 2     Beclin 1-Interacting Protein2
Autophagy-Related Protein 14-Like Protein2 3     Atg14L3
ATG14 Autophagy Related 14 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 199621   Entrez Gene: 228632   Ensembl: ENSG000001267757   OMIM: 6135155   UniProtKB: Q6ZNE53   

Export aliases for ATG14 gene to outside databases

Previous GC identifer: GC14M035996


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ATG14 Gene: 
ATG14 (autophagy related 14) is a protein-coding gene. Diseases associated with ATG14 include human granulocytic anaplasmosis, and hepatitis. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: BAKOR_HUMAN, Q6ZNE5
Function: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific
PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to
phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances
PIK3C3 activity in a BECN1-dependent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ATG14
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ATG14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.3   Ensembl cytogenetic band:  14q22.3   HGNC cytogenetic band: 14q22.2

ATG14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG14 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M055834:  view genomic region     (about GC identifiers)

Start:
55,833,109 bp from pter      End:
55,878,576 bp from pter
Size:
45,468 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BAKOR_HUMAN, Q6ZNE5 (See protein sequence)
Recommended Name: Beclin 1-associated autophagy-related key regulator  
Size: 492 amino acids; 55309 Da
Subunit: Component of the autophagy-specific PI3-kinase complex I composed of ATG14, BECN1, PIK3C3 and PIK3R4, but
not UVRAG, nor KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through
direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon
down-regulates autophagy (By similarity). Interacts with PIK3CB (By similarity)
Subcellular location: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal
structure membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions. Following
autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci,
identified as isolation membranes and autophagosomes. Accumulates on highly curved PtdIns(3)P enriched autophagic
membrane via its BATS domain to sense and maintain membrane curvature (By similarity)
Sequence caution: Sequence=BAA74854.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NJE4 A8K9U5 B7ZWP5 O94920 Q32MK7 Q32MK8
Alternative splicing: 2 isoforms:  Q6ZNE5-1   Q6ZNE5-2   

Explore the universe of human proteins at neXtProt for ATG14: NX_Q6ZNE5

Explore proteomics data for ATG14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZNE5

  • ATG14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATG14 Protein Expression
    REFSEQ proteins: NP_055739.2  
    ENSEMBL proteins: 
     ENSP00000247178  

    Human Recombinant Protein Products for ATG14: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005776autophagic vacuole IDA19270696
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0034045pre-autophagosomal structure membrane IDA19270696

    ATG14 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018791 UV_resistance/autophagy_Atg14

    Graphical View of Domain Structure for InterPro Entry Q6ZNE5

    ProtoNet protein and cluster: Q6ZNE5

    UniProtKB/Swiss-Prot: BAKOR_HUMAN, Q6ZNE5
    Domain: The coiled-coil domain is required for BECN1- and PIK3C3-binding and for autophagy
    Domain: The final 80 residues in the C-terminus define a minimum required region for autophagosome binding called
    BATS (By similarity)
    Similarity: Belongs to the Barkor family


    ATG14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BAKOR_HUMAN, Q6ZNE5
    Function: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific
    PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to
    phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances
    PIK3C3 activity in a BECN1-dependent manner

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19270696
         
    ATG14 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ATG14:
     Increased G1 DNA content  Increased number of mitotic ce  Lamellipodia cells 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATG14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for ATG14
        Senescence and Autophagy



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/260 Interacting proteins for ATG14 (Q6ZNE52, 3 ENSP000002471784) via UniProtKB, MINT, STRING, and/or I2D (see all 260)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IMP19270696
    GO:0006914autophagy ----
    GO:0010508positive regulation of autophagy IEA--

    ATG14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATG14 (BAKOR)

    Search CenterWatch for drugs/clinical trials and news about ATG14 / BAKOR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATG14 gene: 
    NM_014924.4  

    Unigene Cluster for ATG14:

    Autophagy related 14
    Hs.414809  [show with all ESTs]
    Unigene Representative Sequence: NM_014924
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558189(uc001xbw.2) ENST00000247178(uc001xbx.2)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidATG14 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG14

    Additional mRNA sequence: 

    AK131251.1 AK292810.1 AL049978.1 BC028015.1 BC109089.1 BC109090.1 

    8 DOTS entries:

    DT.75155959  DT.446023  DT.100719104  DT.95127636  DT.95159788  DT.410222  DT.100659467  DT.91870643 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATG14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCAGGAAT
    ATG14 Expression
    About this image


    See ATG14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATG14

    SOURCE GeneReport for Unigene cluster: Hs.414809
        SABiosciences Custom PCR Arrays for ATG14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ATG14 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg141 , 5 VATG14 autophagy related 14 homolog (S. cerevisiae)5
    autophagy related 141
    86.86(n)1
    93.09(a)1
      14 (24.60 cM)5
    1005046631  NM_172599.41  NP_766187.11 
     475408945 
    chicken
    (Gallus gallus)
    Aves ATG141 ATG14 autophagy related 14 homolog (S. cerevisiae) 78.62(n)
    84.43(a)
      428922  XM_426476.2  XP_426476.2 
    lizard
    (Anolis carolinensis)
    Reptilia ATG146
    autophagy related 14
    86(a)
    1 ↔ 1
    GL343325.1(338969-356975)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL849775.22   -- 75.99(n)    AL849775.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1139441 zgc:113944 65.81(n)
    67.31(a)
      407686  NM_001024812.1  NP_001019983.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118771 CG11877 42.32(n)
    29.08(a)
      43438  NM_143412.3  NP_651669.1 


    ENSEMBL Gene Tree for ATG14 (if available)
    TreeFam Gene Tree for ATG14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1158 SNPs in ATG14 are shown (see all 1158)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764800891,2
    C,F--55832612(+) TCTACA/GATAAT 1 -- int11Minor allele frequency- G:0.09NA 120
    rs101464411,2
    C,H--55832645(+) CTACCC/TACCTG 1 -- int14Minor allele frequency- T:0.00NS EA 420
    rs1867737631,2
    --55832711(+) CTACTC/GAGGCA 1 -- int10--------
    rs747451031,2
    F--55832924(+) GATCAT/ATGTTA 1 -- int11Minor allele frequency- A:0.50NA 4
    rs1912433901,2
    --55832953(+) ATTTTA/TAAAAA 1 -- int10--------
    rs1857387511,2
    --55832956(+) TTAAAA/GAATAT 1 -- int10--------
    rs1441505031,2
    --55832994(+) AAATTA/CTACAA 1 -- int10--------
    rs1465305221,2
    --55833019(+) TTGTAC/TAAAGT 1 -- int10--------
    rs22978161,2
    C,F,O,H--55833038(-) TGAGAC/TTGAAC 1 -- int131Minor allele frequency- N:0.00EA NS NA WA CSA 4476
    rs1408761741,2
    --55833098(+) ATACAC/TATGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ATG14 (55833109 - 55878576 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ATG14:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv901957CNV Gain21882294
    nsv901959CNV Gain21882294
    dgv1937n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613515    OMIM disorders: --

    2 diseases for ATG14:    About MalaCards
    human granulocytic anaplasmosis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for ATG14:
    Human granulocytic anaplasmosis

    ATG14 for disorders           About GeneDecksing


    Export disorders for ATG14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATG14 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ATG14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PubMed id 18843052)1, 2, 3 Itakura E....Mizushima N. (2008)
    2. Imperfect interface of Beclin1 coiled-coil domain regu lates homodimer and heterodimer formation with Atg14L and UVRAG. (PubMed id 22314358)1, 2 Li X....Zhao Y. (2012)
    3. Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. (PubMed id 20713597)1, 2 Matsunaga K....Yoshimori T. (2010)
    4. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. (PubMed id 19270696)1, 2 Matsunaga K....Yoshimori T. (2009)
    5. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. (PubMed id 19050071)1, 2 Sun Q....Zhong Q. (2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    10. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. (PubMed id 22992773)1 Xiong X....Dong X.C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22863 HGNC: 19962 Ensembl:ENSG00000126775 euGenes: HUgn22863 ECgene: ATG14
    H-InvDB: ATG14

    (According to HUGE)
    About This Section
    HUGE: KIAA0831

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATG14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATG14 gene:
    Search GeneIP for patents involving ATG14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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