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Aliases for ATG14 Gene

Aliases for ATG14 Gene

  • Autophagy Related 14 2 3
  • KIAA0831 2 3 4
  • Beclin 1-Associated Autophagy-Related Key Regulator 2 3
  • Autophagy-Related Protein 14-Like Protein 3 4
  • ATG14L 3 4
  • BARKOR 3 4
  • ATG14 Autophagy Related 14 Homolog (S. Cerevisiae) 2
  • ATG14 Autophagy Related 14 Homolog 3
  • Beclin 1-Interacting Protein 3
  • Barkor 2

External Ids for ATG14 Gene

Previous HGNC Symbols for ATG14 Gene

  • KIAA0831

Previous GeneCards Identifiers for ATG14 Gene

  • GC14M055834
  • GC14M035996

Summaries for ATG14 Gene

GeneCards Summary for ATG14 Gene

ATG14 (Autophagy Related 14) is a Protein Coding gene. Diseases associated with ATG14 include human granulocytic anaplasmosis. Among its related pathways are Senescence and Autophagy and Regulation of autophagy.

UniProtKB/Swiss-Prot for ATG14 Gene

  • Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG14 Gene

Genomics for ATG14 Gene

Genomic Location for ATG14 Gene

Start:
55,366,391 bp from pter
End:
55,411,858 bp from pter
Size:
45,468 bases
Orientation:
Minus strand

Genomic View for ATG14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG14 Gene

No data available for Regulatory Elements for ATG14 Gene

Proteins for ATG14 Gene

  • Protein details for ATG14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNE5-BAKOR_HUMAN
    Recommended name:
    Beclin 1-associated autophagy-related key regulator
    Protein Accession:
    Q6ZNE5
    Secondary Accessions:
    • A6NJE4
    • A8K9U5
    • B7ZWP5
    • O94920
    • Q32MK7
    • Q32MK8

    Protein attributes for ATG14 Gene

    Size:
    492 amino acids
    Molecular mass:
    55309 Da
    Quaternary structure:
    • Component of the autophagy-specific PI3-kinase complex I composed of ATG14, BECN1, PIK3C3 and PIK3R4, but not UVRAG, nor KIAA0226/Rubicon. UVRAG and ATG14/Barkor form mutually exclusive complexes with BECN1 through direct competition. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy (By similarity). Interacts with PIK3CB (By similarity). Interacts with BECN2.
    SequenceCaution:
    • Sequence=BAA74854.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG14 Gene

Proteomics data for ATG14 Gene at MOPED

Post-translational modifications for ATG14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ATG14 Gene

Domains for ATG14 Gene

Protein Domains for ATG14 Gene

Suggested Antigen Peptide Sequences for ATG14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNE5

UniProtKB/Swiss-Prot:

BAKOR_HUMAN :
  • Q6ZNE5
Domain:
  • The coiled-coil domain is required for BECN1- and PIK3C3-binding and for autophagy.
  • The final 80 residues in the C-terminus define a minimum required region for autophagosome binding called BATS.
  • The N-terminal cysteine repeats are required for proper localization to the endoplasmic reticulum.
Family:
  • Belongs to the ATG14 family.
genes like me logo Genes that share domains with ATG14: view

No data available for Gene Families for ATG14 Gene

Function for ATG14 Gene

Molecular function for ATG14 Gene

UniProtKB/Swiss-Prot Function: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (By similarity).

Gene Ontology (GO) - Molecular Function for ATG14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19270696
genes like me logo Genes that share ontologies with ATG14: view

Phenotypes for ATG14 Gene

genes like me logo Genes that share phenotypes with ATG14: view

Animal Model Products

CRISPR Products

miRNA for ATG14 Gene

miRTarBase miRNAs that target ATG14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATG14 Gene

Localization for ATG14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG14 Gene

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes. Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG14 Gene COMPARTMENTS Subcellular localization image for ATG14 gene
Compartment Confidence
endoplasmic reticulum 5
vacuole 5
cytosol 2
lysosome 2
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for ATG14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005776 autophagic vacuole IDA 19270696
GO:0005783 endoplasmic reticulum --
genes like me logo Genes that share ontologies with ATG14: view

Pathways for ATG14 Gene

genes like me logo Genes that share pathways with ATG14: view

Pathways by source for ATG14 Gene

1 BioSystems pathway for ATG14 Gene
1 KEGG pathway for ATG14 Gene

Gene Ontology (GO) - Biological Process for ATG14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IMP 19270696
GO:0001932 regulation of protein phosphorylation IMP 23878393
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0006914 autophagy --
genes like me logo Genes that share ontologies with ATG14: view

Transcripts for ATG14 Gene

mRNA/cDNA for ATG14 Gene

(6) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ATG14 Gene

Autophagy related 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG14

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ATG14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG14 Gene

No ASD Table

Relevant External Links for ATG14 Gene

GeneLoc Exon Structure for
ATG14
ECgene alternative splicing isoforms for
ATG14

Expression for ATG14 Gene

mRNA expression in normal human tissues for ATG14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG14 Gene

SOURCE GeneReport for Unigene cluster for ATG14 Gene Hs.414809

genes like me logo Genes that share expressions with ATG14: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATG14 Gene

Orthologs for ATG14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG14 35
  • 99.86 (n)
  • 99.8 (a)
ATG14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATG14 35
  • 90.65 (n)
  • 95.73 (a)
ATG14 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG14 35
  • 91.8 (n)
  • 95.73 (a)
ATG14 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg14 35
  • 86.86 (n)
  • 93.09 (a)
Atg14 16
Atg14 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATG14 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG14 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg14 35
  • 85.03 (n)
  • 92.28 (a)
chicken
(Gallus gallus)
Aves ATG14 35
  • 78.62 (n)
  • 84.43 (a)
ATG14 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG14 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg14 35
  • 72.03 (n)
  • 78.21 (a)
zebrafish
(Danio rerio)
Actinopterygii ATG14 36
  • 43 (a)
OneToOne
zgc:113944 35
  • 65.73 (n)
  • 67.31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012246 35
  • 42.73 (n)
  • 33.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11877 35
  • 42.72 (n)
  • 30.31 (a)
CG11877 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
CSA.2684 36
  • 32 (a)
OneToMany
Species with no ortholog for ATG14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ATG14 Gene

ENSEMBL:
Gene Tree for ATG14 (if available)
TreeFam:
Gene Tree for ATG14 (if available)

Paralogs for ATG14 Gene

No data available for Paralogs for ATG14 Gene

Variants for ATG14 Gene

Sequence variations from dbSNP and Humsavar for ATG14 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs861713 -- 55,379,421(-) gggac(A/C)acagg intron-variant
rs861714 -- 55,379,294(-) cctcc(A/C)acagt intron-variant
rs861715 -- 55,379,158(-) gccaa(A/C)actgg intron-variant
rs861716 -- 55,379,107(-) gagct(A/C)acatt intron-variant
rs861717 -- 55,378,272(-) TATGT(C/G)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG14 Gene

Variant ID Type Subtype PubMed ID
nsv901957 CNV Gain 21882294
dgv1937n71 CNV Gain 21882294
nsv901959 CNV Gain 21882294

Relevant External Links for ATG14 Gene

HapMap Linkage Disequilibrium report
ATG14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG14 Gene

Disorders for ATG14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ATG14 Gene including...

Search for ATG14 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ATG14 Gene

genes like me logo Genes that share disorders with ATG14: view

No data available for UniProtKB/Swiss-Prot for ATG14 Gene

Publications for ATG14 Gene

  1. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (PMID: 18843052) Itakura E. … Mizushima N. (Mol. Biol. Cell 2008) 2 3 4
  2. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. (PMID: 19050071) Sun Q. … Zhong Q. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4
  3. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. (PMID: 19270696) Matsunaga K. … Yoshimori T. (Nat. Cell Biol. 2009) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ATG14 Gene

  • Addgene plasmids for ATG14

Sources for ATG14 Gene

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