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ATG13 Gene

protein-coding   GIFtS: 53
GCID: GC11P046638

Autophagy Related 13

(Previous names: KIAA0652, ATG13 autophagy related 13 homolog (S. cerevisiae))
(Previous symbol: KIAA0652)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Autophagy Related 131 2
KIAA06521 2 3 5
PARATARG82 5
ATG13 Autophagy Related 13 Homolog (S. Cerevisiae)1
ATG13 Autophagy Related 13 Homolog2
Autophagy-Related Protein 132

External Ids:    HGNC: 290911   Entrez Gene: 97762   Ensembl: ENSG000001752247   OMIM: 6150885   UniProtKB: O751433   

Export aliases for ATG13 gene to outside databases

Previous GC identifer: GC11P046345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ATG13 Gene:
ATG13 (autophagy related 13) is a protein-coding gene. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot: ATG13_HUMAN, O75143
Function: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling
pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the
regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the
regulation of the kinase activity of mTORC1 and cell proliferation

Gene Wiki entry for ATG13 (Autophagy-related protein 13) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ATG13
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG13 promoter sequence
   Search Chromatin IP Primers for ATG13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATG13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ATG13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG13 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P046638:  view genomic region     (about GC identifiers)

Start:
46,638,826 bp from pter      End:
46,697,569 bp from pter
Size:
58,744 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ATG13_HUMAN, O75143 (See protein sequence)
Recommended Name: Autophagy-related protein 13  
Size: 517 amino acids; 56572 Da
Subunit: Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 (via
C-terminus). Interacts with ULK2 (via C-terminus). Interacts (via the LIR motif) with GABARAP, GABARAPL,
GABARAPL2, and LC3A. Interacts with TAB2 and TAB3
Sequence caution: Sequence=BAA31627.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAD97323.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for ATG13:
3WAN (3D)        3WAO (3D)        3WAP (3D)    
Secondary accessions: B4DFI4 D3DQQ1 D3DQQ2 E9PQZ8 Q53EN6 Q9BRL3 Q9H8B0
Alternative splicing: 5 isoforms:  O75143-1   O75143-2   O75143-3   O75143-4   O75143-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATG13: NX_O75143

Explore proteomics data for ATG13 at MOPED

Post-translational modifications: 

  • Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions;
    dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13
    at Ser-355 is required for efficient clearance of depolarized mitochondria1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ATG13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001136145.1  NP_001192048.1  NP_001192049.1  NP_001192050.1  NP_001192051.1  NP_055556.2  

    ENSEMBL proteins: 
     ENSP00000463808   ENSP00000464274   ENSP00000433756   ENSP00000436931   ENSP00000463550  
     ENSP00000463998   ENSP00000434390   ENSP00000431974   ENSP00000462644   ENSP00000462167  
     ENSP00000433543   ENSP00000464091   ENSP00000352500   ENSP00000432412   ENSP00000378919  
     ENSP00000434125   ENSP00000436174   ENSP00000431877   ENSP00000437191   ENSP00000400642  
     ENSP00000310321   ENSP00000404900  

    ATG13 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ATG13

     
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    antibodies-online proteins for ATG13 (5 products) 

     
    antibodies-online peptides for ATG13

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    ATG13 Assay Products:

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    Cloud-Clone Corp. CLIAs for ATG13
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018731 Autophagy-rel_p13

    Graphical View of Domain Structure for InterPro Entry O75143

    ProtoNet protein and cluster: O75143

    UniProtKB/Swiss-Prot: ATG13_HUMAN, O75143
    Domain: The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins
    GABARAP, GABARAPL, GABARAPL2, and LC3A
    Similarity: Belongs to the ATG13 metazoan family


    Find genes that share domains with ATG13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATG13_HUMAN, O75143
    Function: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling
    pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the
    regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the
    regulation of the kinase activity of mTORC1 and cell proliferation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19211835
    GO:0019901protein kinase binding IPI18936157
         
    Find genes that share ontologies with ATG13           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ATG13:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ATG13

    miRNA
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    miRTarBase miRNAs that target ATG13:
    hsa-mir-10b-5p (MIRT047462)

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    Selected qRT-PCR Assays for microRNAs that regulate ATG13 (see all 55):
    hsa-miR-548j hsa-miR-548k hsa-miR-15a hsa-miR-765 hsa-miR-371-5p hsa-miR-3921 hsa-miR-766 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidATG13 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATG13_HUMAN, O75143: Cytoplasm, cytosol (By similarity). Preautophagosomal structure (By similarity). Note=Under
    starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the
    isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    vacuole2
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000407pre-autophagosomal structure ISS--
    GO:0005829cytosol IEA--
    GO:0070969ULK1-ATG13-FIP200 complex IPI19211835

    Find genes that share ontologies with ATG13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATG13 About    
    See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy
    2Regulation of autophagy
    Regulation of autophagy
    3mTOR signaling pathway
    mTOR signaling pathway


    Find genes that share SuperPaths with ATG13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ATG13
        Senescence and Autophagy
    mTOR signaling pathway



    1 Kegg Pathway  (Kegg details for ATG13):
        Regulation of autophagy

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ATG13
    Interactions:

        Search GeneGlobe Interaction Network for ATG13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ATG13 (O751431, 2, 3 ENSP000003103214) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IMP19211835

    Find genes that share ontologies with ATG13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATG13



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ATG13 gene (6 alternative transcripts): 
    NM_001142673.2  NM_001205119.1  NM_001205120.1  NM_001205121.1  NM_001205122.1  NM_014741.4  

    Unigene Cluster for ATG13:

    Autophagy related 13
    Hs.127403  [show with all ESTs]
    Unigene Representative Sequence: NM_001205119
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000580238 ENST00000579280 ENST00000581416 ENST00000529655 ENST00000526715
    ENST00000533325 ENST00000581438 ENST00000583249 ENST00000530500 ENST00000526508
    ENST00000578626 ENST00000577256 ENST00000524625 ENST00000530942 ENST00000534610
    ENST00000582547 ENST00000359513 ENST00000528494
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ATG13 (see all 55):
    hsa-miR-548j hsa-miR-548k hsa-miR-15a hsa-miR-765 hsa-miR-371-5p hsa-miR-3921 hsa-miR-766 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidATG13 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for ATG13 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ATG13
      QuantiFast Probe-based Assays in human, mouse, rat ATG13

    Additional mRNA sequence: 

    AB014552.1 AF052175.1 AK000705.1 AK023867.1 AK223603.1 AK289641.1 AK293109.1 AK296526.1 
    AK315925.1 BC001331.1 BC002378.2 BC006191.2 

    Selected DOTS entries (see all 39):

    DT.95217300  DT.101984421  DT.95208193  DT.456412  DT.95217336  DT.120718171  DT.100845976  DT.120718182 
    DT.92449871  DT.100845975  DT.120718262  DT.97864334  DT.40131395  DT.120718178  DT.95217256  DT.97792090 
    DT.104339  DT.120718223  DT.92449892  DT.92449897  DT.120718196  DT.120718259  DT.95345803  DT.97864332 

    Selected AceView cDNA sequences (see all 453):

    AA005193 AU125065 BX342671 BM785886 CB136723 BM746826 AI675420 Z40791 
    BM454685 BG191611 BF110185 F01664 BE906858 BX402959 T34891 BQ686355 
    AI373799 W03546 BC002378 BQ219331 BQ065680 BX339051 BC006191 BP338244 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ATG13 (see all 31)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a ·
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -                                                     -   
    SP2:                          -           -     -     -     -     -     -     -     -     -     -     -                                                     -   
    SP3:                          -     -     -     -     -     -     -     -     -     -     -     -     -                                                     -   
    SP4:                          -     -     -     -     -     -     -     -     -     -     -                                                                 -   
    SP5:                          -                       -     -     -     -     -     -     -                                                                     

    ExUns: 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
    SP1:                          -           -                                                                           
    SP2:                          -     -     -     -                                                                     
    SP3:                          -     -     -                                                                           
    SP4:                          -     -     -     -                                                                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ATG13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATG13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAATAAAA
    ATG13 Expression
    About this image


    ATG13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
    ATG13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ATG13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127403
        Custom PCR Arrays for ATG13
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ATG13 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg131 , 5 ATG13 autophagy related 13 homolog (S. cerevisiae)5
    autophagy related 131
    87.09(n)1
    91.62(a)1
      2 (50.63 cM)5
    518971  NM_145528.31  NP_663503.11 
     916746185 
    chicken
    (Gallus gallus)
    Aves ATG131 autophagy related 13 83.66(n)
    93.39(a)
      423192  XM_003641388.2  XP_003641436.2 
    lizard
    (Anolis carolinensis)
    Reptilia ATG136
    autophagy related 13
    89(a)
    1 ↔ 1
    1(43004922-43038625)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.178972 Xenopus laevis transcribed sequence with weak similarity more 80.5(n)    BU900721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635262 hypothetical protein MGC63526 77.63(n)   393405  BC054904.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atg136
    Autophagy-specific gene 13
    30(a)
    1 ↔ 1
    3R(4175524-4178539)
    worm
    (Caenorhabditis elegans)
    Secernentea atg-136
    Protein ATG-13 (atg-13) mRNA, complete cds
    26(a)
    1 ↔ 1
    III(8155990-8158245) WBGene00017045


    ENSEMBL Gene Tree for ATG13 (if available)
    TreeFam Gene Tree for ATG13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATG13 (see all 1109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447342941,2
    --46562703(+) CATGCC/TCAATT 6 -- us2k10--------
    rs1896789041,2
    --46562825(+) CCACCA/GCCCCC 6 -- us2k10--------
    rs776616631,2
    C,F--46562838(+) CCTACA/GTAACT 6 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1475998791,2
    F--46562938(+) ACTGAG/AGGAAG 6 -- us2k11Minor allele frequency- A:0.00NA 4552
    rs1417499981,2
    C,F--46562967(+) AGTCCT/CGTAGG 6 -- us2k12Minor allele frequency- C:0.00NA EU 5875
    rs2008445011,2
    C--46562980(+) GCCGGA/GCCAGT 6 -- us2k10--------
    rs1995809771,2
    --46562991(+) TTGTCC/TCCACG 6 -- us2k10--------
    rs1384854121,2
    C--46563017(+) CTAATG/TTCACA 6 -- us2k11Minor allele frequency- T:0.00NA 4552
    rs1492101131,2
    C,F--46563058(+) TTTTCG/AGTTCA 6 -- us2k11Minor allele frequency- A:0.00NA 4552
    rs1482945201,2
    C--46563153(+) ACCCAT/CAGAAT 6 -- us2k11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for ATG13 (46638826 - 46697569 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ATG13:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv38662CNV Loss16902084
    nsv897321CNV Gain21882294
    esv993220OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATG13
    DNA2.0 Custom Variant and Variant Library Synthesis for ATG13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615088    OMIM disorders: --


    Find genes that share disorders with ATG13           About GenesLikeMe


    Export disorders for ATG13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATG13 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with ATG13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. (PubMed id 23043107)1, 2 Alemu E.A.... Johansen T. (J. Biol. Chem. 2012)
    2. TGFbeta-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy. (PubMed id 21976705)1, 2 Takaesu G.... Yoshimura A. (J. Biochem. 2012)
    3. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (PubMed id 19211835)1, 2 Hosokawa N....Mizushima N. (Mol. Biol. Cell 2009)
    4. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PubMed id 19287211)1, 2 Mercer C.A.... Dennis P.B. (Autophagy 2009)
    5. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PubMed id 18936157)1, 2 Chan E.Y.W.... Tooze S.A. (Mol. Cell. Biol. 2009)
    6. Atg101, a novel mammalian autophagy protein interacting with Atg13. (PubMed id 19597335)1, 2 Hosokawa N....Mizushima N. (Autophagy 2009)
    7. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. (PubMed id 19225151)1, 2 Jung C.H....Kim D.H. (Mol. Biol. Cell 2009)
    8. ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. (PubMed id 17204848)1, 3 Meijer W.H....Kiel J.A. (Autophagy 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9776 HGNC: 29091 AceView: KIAA0652 Ensembl:ENSG00000175224 euGenes: HUgn9776
    ECgene: ATG13 Kegg: 9776 H-InvDB: ATG13

    (According to HUGE)
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    HUGE: KIAA0652

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ATG13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATG13 gene:
    Search GeneIP for patents involving ATG13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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