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Aliases for ATG13 Gene

Aliases for ATG13 Gene

  • Autophagy Related 13 2 3
  • KIAA0652 2 3 4
  • ATG13 Autophagy Related 13 Homolog (S. Cerevisiae) 2
  • ATG13 Autophagy Related 13 Homolog 3
  • PARATARG8 3

External Ids for ATG13 Gene

Previous HGNC Symbols for ATG13 Gene

  • KIAA0652

Previous GeneCards Identifiers for ATG13 Gene

  • GC11P046345

Summaries for ATG13 Gene

GeneCards Summary for ATG13 Gene

ATG13 (Autophagy Related 13) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Senescence and Autophagy. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for ATG13 Gene

  • Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Gene Wiki entry for ATG13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG13 Gene

Genomics for ATG13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATG13 Gene

Chromosome:
11
Start:
46,617,276 bp from pter
End:
46,676,019 bp from pter
Size:
58,744 bases
Orientation:
Plus strand

Genomic View for ATG13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG13 Gene

No data available for Regulatory Elements for ATG13 Gene

Proteins for ATG13 Gene

  • Protein details for ATG13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75143-ATG13_HUMAN
    Recommended name:
    Autophagy-related protein 13
    Protein Accession:
    O75143
    Secondary Accessions:
    • B4DFI4
    • D3DQQ1
    • D3DQQ2
    • E9PQZ8
    • Q53EN6
    • Q9BRL3
    • Q9H8B0

    Protein attributes for ATG13 Gene

    Size:
    517 amino acids
    Molecular mass:
    56572 Da
    Quaternary structure:
    • Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 (via C-terminus). Interacts with ULK2 (via C-terminus). Interacts (via the LIR motif) with GABARAP, GABARAPL, GABARAPL2, and LC3A. Interacts with TAB2 and TAB3.
    SequenceCaution:
    • Sequence=BAA31627.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97323.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATG13 Gene

    Alternative splice isoforms for ATG13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG13 Gene

Proteomics data for ATG13 Gene at MOPED

Post-translational modifications for ATG13 Gene

  • Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ATG13 (ATG13)

No data available for DME Specific Peptides for ATG13 Gene

Domains & Families for ATG13 Gene

Gene Families for ATG13 Gene

Protein Domains for ATG13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75143

UniProtKB/Swiss-Prot:

ATG13_HUMAN :
  • The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and LC3A.
  • Belongs to the ATG13 metazoan family.
Domain:
  • The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and LC3A.
Family:
  • Belongs to the ATG13 metazoan family.
genes like me logo Genes that share domains with ATG13: view

Function for ATG13 Gene

Molecular function for ATG13 Gene

UniProtKB/Swiss-Prot Function:
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Gene Ontology (GO) - Molecular Function for ATG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19211835
GO:0019901 protein kinase binding IPI 18936157
genes like me logo Genes that share ontologies with ATG13: view
genes like me logo Genes that share phenotypes with ATG13: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG13 Gene

Localization for ATG13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG13 Gene

Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG13 Gene COMPARTMENTS Subcellular localization image for ATG13 gene
Compartment Confidence
mitochondrion 4
cytosol 3
lysosome 2
nucleus 2
plasma membrane 2
vacuole 2

Gene Ontology (GO) - Cellular Components for ATG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure ISS --
GO:0005739 mitochondrion IDA 21855797
GO:0005829 cytosol TAS --
GO:1990316 ATG1/UKL1 kinase complex IPI 19211835
genes like me logo Genes that share ontologies with ATG13: view

Pathways & Interactions for ATG13 Gene

genes like me logo Genes that share pathways with ATG13: view

Pathways by source for ATG13 Gene

2 BioSystems pathways for ATG13 Gene
2 Reactome pathways for ATG13 Gene
1 KEGG pathway for ATG13 Gene

SIGNOR curated interactions for ATG13 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ATG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IMP 19211835
GO:0006914 autophagy --
GO:0016236 macroautophagy TAS --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with ATG13: view

Drugs & Compounds for ATG13 Gene

No Compound Related Data Available

Transcripts for ATG13 Gene

Unigene Clusters for ATG13 Gene

Autophagy related 13:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - -
SP12:
SP13: - - - - - - - - - - -
SP14: - -
SP15: - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - - -
SP18:
SP19:
SP20:
SP21: - - - - - - - - - - - - - - -
SP22: - - - - - - -
SP23: - - - - - - - -
SP24: - - - -
SP25: -
SP26: - -
SP27: - - - - - -
SP28: - - - -
SP29:
SP30:
SP31:

ExUns: 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - - -
SP20: -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30: - - - - - - - - - - -
SP31:

Relevant External Links for ATG13 Gene

GeneLoc Exon Structure for
ATG13
ECgene alternative splicing isoforms for
ATG13

Expression for ATG13 Gene

mRNA expression in normal human tissues for ATG13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ATG13 Gene

This gene is overexpressed in Neutrophil (25.9), Monocytes (16.6), and Testis (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG13 Gene



SOURCE GeneReport for Unigene cluster for ATG13 Gene Hs.127403

genes like me logo Genes that share expression patterns with ATG13: view

Protein tissue co-expression partners for ATG13 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATG13 Gene

Orthologs for ATG13 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ATG13 35
  • 89.86 (n)
  • 93.71 (a)
ATG13 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG13 35
  • 93.7 (n)
  • 98.18 (a)
ATG13 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg13 35
  • 87.09 (n)
  • 91.62 (a)
Atg13 16
Atg13 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ATG13 35
  • 97.55 (n)
  • 96.93 (a)
ATG13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg13 35
  • 88.36 (n)
  • 92.81 (a)
oppossum
(Monodelphis domestica)
Mammalia ATG13 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG13 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG13 35
  • 83.66 (n)
  • 93.39 (a)
ATG13 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG13 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg13 35
  • 71.26 (n)
  • 75.98 (a)
Str.15163 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17897 35
zebrafish
(Danio rerio)
Actinopterygii atg13 35
  • 69.78 (n)
  • 74.55 (a)
zgc63526 35
atg13 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1013 35
fruit fly
(Drosophila melanogaster)
Insecta Atg13 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea atg-13 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for ATG13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG13 Gene

ENSEMBL:
Gene Tree for ATG13 (if available)
TreeFam:
Gene Tree for ATG13 (if available)

Paralogs for ATG13 Gene

No data available for Paralogs for ATG13 Gene

Variants for ATG13 Gene

Sequence variations from dbSNP and Humsavar for ATG13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12989 -- 46,674,113(+) CCCTG(C/G)TAAGT utr-variant-3-prime
rs13448 -- 46,673,864(+) GGTGG(C/T)TCTCA utr-variant-3-prime
rs1131306 -- 46,672,968(+) AGGGT(C/T)TGAGC utr-variant-3-prime
rs1131308 -- 46,673,029(+) ATGGC(A/C)CCCTG utr-variant-3-prime
rs1140550 -- 46,672,971(+) GTCTG(A/G)GCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATG13 Gene

Variant ID Type Subtype PubMed ID
nsv897321 CNV Gain 21882294
esv993220 OTHER Inversion 20482838
nsv38662 CNV Loss 16902084

Variation tolerance for ATG13 Gene

Residual Variation Intolerance Score: 70.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG13 Gene

HapMap Linkage Disequilibrium report
ATG13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG13 Gene

Disorders for ATG13 Gene

Relevant External Links for ATG13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG13
genes like me logo Genes that share disorders with ATG13: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG13 Gene

Publications for ATG13 Gene

  1. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. (PMID: 18339812) Sinzelle L. … Ivics Z. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 67
  2. ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. (PMID: 17204848) Meijer W.H. … Kiel J.A. (Autophagy 2007) 2 67
  3. Harbinger transposons and an ancient HARBI1 gene derived from a transposase. (PMID: 15169610) Kapitonov V.V. … Jurka J. (DNA Cell Biol. 2004) 2 67
  4. Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy. (PMID: 26018823) Li J. … Zhu Y. (Autophagy 2015) 67
  5. Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism. (PMID: 24290141) Suzuki H. … Wakatsuki S. (Structure 2014) 67

Products for ATG13 Gene

Sources for ATG13 Gene

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