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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATG13 Gene

protein-coding   GIFtS: 52
GCID: GC11P046638

Autophagy Related 13

(Previous names: KIAA0652, ATG13 autophagy related 13 homolog (S. cerevisiae))
(Previous symbol: KIAA0652)
  Search for ATG13
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Autophagy Related 131 2
KIAA06521 2 3
ATG13 Autophagy Related 13 Homolog (S. Cerevisiae)1
PARATARG82
ATG13 Autophagy Related 13 Homolog2
Autophagy-Related Protein 132

External Ids:    HGNC: 290911   Entrez Gene: 97762   Ensembl: ENSG000001752247   OMIM: 6150885   UniProtKB: O751433   

Export aliases for ATG13 gene to outside databases

Previous GC identifer: GC11P046345


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ATG13 Gene: 
ATG13 (autophagy related 13) is a protein-coding gene. GO annotations related to this gene include protein binding and protein kinase binding.

UniProtKB/Swiss-Prot: ATG13_HUMAN, O75143
Function: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling
pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the
regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the
regulation of the kinase activity of mTORC1 and cell proliferation

Gene Wiki entry for ATG13 (Autophagy-related protein 13) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ATG13
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG13 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATG13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ATG13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG13 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P046638:  view genomic region     (about GC identifiers)

Start:
46,638,826 bp from pter      End:
46,697,569 bp from pter
Size:
58,744 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ATG13_HUMAN, O75143 (See protein sequence)
Recommended Name: Autophagy-related protein 13  
Size: 517 amino acids; 56572 Da
Subunit: Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 (via
C-terminus). Interacts with ULK2 (via C-terminus). Interacts (via the LIR motif) with GABARAP, GABARAPL,
GABARAPL2, and LC3A. Interacts with TAB2 and TAB3
Subcellular location: Cytoplasm, cytosol (By similarity). Preautophagosomal structure (By similarity). Note=Under
starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the
isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation (By similarity)
Sequence caution: Sequence=BAA31627.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAD97323.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DFI4 D3DQQ1 D3DQQ2 E9PQZ8 Q53EN6 Q9BRL3 Q9H8B0
Alternative splicing: 5 isoforms:  O75143-1   O75143-2   O75143-3   O75143-4   O75143-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATG13: NX_O75143

Explore proteomics data for ATG13 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions;
    dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13
    at Ser-355 is required for efficient clearance of depolarized mitochondria
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75143

  • ATG13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ATG13 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001136145.1  NP_001192048.1  NP_001192049.1  NP_001192050.1  NP_001192051.1  NP_055556.2  

    ENSEMBL proteins: 
     ENSP00000463808   ENSP00000464274   ENSP00000433756   ENSP00000436931   ENSP00000463550  
     ENSP00000463998   ENSP00000434390   ENSP00000431974   ENSP00000462644   ENSP00000462167  
     ENSP00000433543   ENSP00000464091   ENSP00000352500   ENSP00000432412   ENSP00000378919  
     ENSP00000434125   ENSP00000436174   ENSP00000431877   ENSP00000437191   ENSP00000400642  
     ENSP00000310321   ENSP00000404900  

    Human Recombinant Protein Products for ATG13: 
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    Cloud-Clone Corp. Proteins for ATG13 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000407pre-autophagosomal structure ISS--
    GO:0005829cytosol IEA--
    GO:0070969ULK1-ATG13-FIP200 complex IPI19211835

    ATG13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018731 Autophagy-rel_p13

    Graphical View of Domain Structure for InterPro Entry O75143

    ProtoNet protein and cluster: O75143

    UniProtKB/Swiss-Prot: ATG13_HUMAN, O75143
    Domain: The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins
    GABARAP, GABARAPL, GABARAPL2, and LC3A
    Similarity: Belongs to the ATG13 metazoan family


    ATG13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATG13_HUMAN, O75143
    Function: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling
    pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the
    regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the
    regulation of the kinase activity of mTORC1 and cell proliferation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19211835
    GO:0019901protein kinase binding IPI18936157
         
    ATG13 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ATG13:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability of wild-ty 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidATG13 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ATG13 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mTOR signaling pathway
    mTOR signaling pathway
    2Senescence and Autophagy
    Senescence and Autophagy


    2 BioSystems Pathways for ATG13
        Senescence and Autophagy
    mTOR signaling pathway



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/202 Interacting proteins for ATG13 (O751431, 2, 3 ENSP000003103214) via UniProtKB, MINT, STRING, and/or I2D (see all 202)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IMP19211835

    ATG13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ATG13

    Search CenterWatch for drugs/clinical trials and news about ATG13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ATG13 gene (6 alternative transcripts): 
    NM_001142673.2  NM_001205119.1  NM_001205120.1  NM_001205121.1  NM_001205122.1  NM_014741.4  

    Unigene Cluster for ATG13:

    Autophagy related 13
    Hs.127403  [show with all ESTs]
    Unigene Representative Sequence: NM_001205119
    18/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000580238 ENST00000579280 ENST00000581416 ENST00000529655 ENST00000526715
    ENST00000533325 ENST00000581438 ENST00000583249 ENST00000530500 ENST00000526508
    ENST00000578626 ENST00000577256 ENST00000524625 ENST00000530942 ENST00000534610
    ENST00000582547 ENST00000359513 ENST00000528494
    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate ATG13 (see all 55):
    hsa-miR-548j hsa-miR-548k hsa-miR-15a hsa-miR-765 hsa-miR-371-5p hsa-miR-3921 hsa-miR-766 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidATG13 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB014552.1 AF052175.1 AK000705.1 AK023867.1 AK223603.1 AK289641.1 AK293109.1 AK296526.1 
    AK315925.1 BC001331.1 BC002378.2 BC006191.2 

    24/39 DOTS entries (see all 39):

    DT.95217300  DT.101984421  DT.95208193  DT.456412  DT.95217336  DT.120718171  DT.100845976  DT.120718182 
    DT.92449871  DT.100845975  DT.120718262  DT.97864334  DT.40131395  DT.120718178  DT.95217256  DT.97792090 
    DT.104339  DT.120718223  DT.92449892  DT.92449897  DT.120718196  DT.120718259  DT.95345803  DT.97864332 

    24/453 AceView cDNA sequences (see all 453):

    BQ054585 BF110185 BE503112 CR604021 AI142351 BQ227838 BE741158 AB014552 
    T34891 BQ920050 CD675643 Z45058 BI257972 BU625403 BP345651 BM457863 
    BX482191 BM709683 BG191611 BU528264 AA435916 BQ065680 AI824148 BM550243 

    GeneLoc Exon Structure

    5/31 Alternative Splicing Database (ASD) splice patterns (SP) for ATG13 (see all 31)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a ·
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -                                                     -   
    SP2:                          -           -     -     -     -     -     -     -     -     -     -     -                                                     -   
    SP3:                          -     -     -     -     -     -     -     -     -     -     -     -     -                                                     -   
    SP4:                          -     -     -     -     -     -     -     -     -     -     -                                                                 -   
    SP5:                          -                       -     -     -     -     -     -     -                                                                     

    ExUns: 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
    SP1:                          -           -                                                                           
    SP2:                          -     -     -     -                                                                     
    SP3:                          -     -     -                                                                           
    SP4:                          -     -     -     -                                                                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ATG13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATG13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAATAAAA
    ATG13 Expression
    About this image


    See ATG13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATG13

    SOURCE GeneReport for Unigene cluster: Hs.127403
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ATG13 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg131 , 5 ATG13 autophagy related 13 homolog (S. cerevisiae)5
    autophagy related 131
    88.94(n)1
    94.36(a)1
      2 (50.63 cM)5
    518971  NM_145528.31  NP_663503.11 
     916746185 
    chicken
    (Gallus gallus)
    Aves ATG131 ATG13 autophagy related 13 homolog (S. cerevisiae) 83.53(n)
    93.39(a)
      423192  XM_003641388.1  XP_003641436.1 
    lizard
    (Anolis carolinensis)
    Reptilia ATG136
    Uncharacterized protein
    88(a)
    1 ↔ 1
    1(43004922-43038625)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.178972 Xenopus laevis transcribed sequence with weak similarity more 80.5(n)    BU900721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635262 hypothetical protein MGC63526 77.63(n)   393405  BC054904.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Atg136
    Autophagy-specific gene 13
    28(a)
    1 ↔ 1
    3R(4175524-4178539)
    worm
    (Caenorhabditis elegans)
    Secernentea atg-136
    Autophagy-related protein 13 homolog
    22(a)
    1 ↔ 1
    III(8155990-8158245)


    ENSEMBL Gene Tree for ATG13 (if available)
    TreeFam Gene Tree for ATG13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1109 SNPs in ATG13 are shown (see all 1109)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447342941,2
    --46562703(+) CATGCC/TCAATT 6 -- us2k10--------
    rs1896789041,2
    --46562825(+) CCACCA/GCCCCC 6 -- us2k10--------
    rs776616631,2
    C,F--46562838(+) CCTACA/GTAACT 6 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1475998791,2
    F--46562938(+) ACTGAG/AGGAAG 6 -- us2k11Minor allele frequency- A:0.00NA 4552
    rs1417499981,2
    C,F--46562967(+) AGTCCT/CGTAGG 6 -- us2k12Minor allele frequency- C:0.00NA EU 5875
    rs2008445011,2
    C--46562980(+) GCCGGA/GCCAGT 6 -- us2k10--------
    rs1995809771,2
    --46562991(+) TTGTCC/TCCACG 6 -- us2k10--------
    rs1384854121,2
    C--46563017(+) CTAATG/TTCACA 6 -- us2k11Minor allele frequency- T:0.00NA 4552
    rs1492101131,2
    C,F--46563058(+) TTTTCG/AGTTCA 6 -- us2k11Minor allele frequency- A:0.00NA 4552
    rs1482945201,2
    C--46563153(+) ACCCAT/CAGAAT 6 -- us2k11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for ATG13 (46638826 - 46697569 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ATG13:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv38662CNV Loss16902084
    nsv897321CNV Gain21882294
    esv993220OTHER Inversion20482838

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ATG13 for disorders           About MalaCards
    OMIM gene information: 615088    OMIM disorders: --


    ATG13 for disorders           About GeneDecksing


    Export disorders for ATG13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATG13 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with ATG13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. (PubMed id 23043107)1, 2 Alemu E.A....Johansen T. (2012)
    2. TGFb-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy. (PubMed id 21976705)1, 2 Takaesu G....Yoshimura A. (2012)
    3. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (PubMed id 19211835)1, 2 Hosokawa N....Mizushima N. (2009)
    4. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PubMed id 19287211)1, 2 Mercer C.A.... Dennis P.B. (2009)
    5. Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. (PubMed id 18936157)1, 2 Chan E.Y....Tooze S.A. (2009)
    6. Atg101, a novel mammalian autophagy protein interacting with Atg13. (PubMed id 19597335)1, 2 Hosokawa N....Mizushima N. (2009)
    7. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. (PubMed id 19225151)1, 2 Jung C.H....Kim D.H. (2009)
    8. ATG genes involved in non-selective autophagy are con served from yeast to man, but the selective Cvt and pexophagy pathways also req uire organism-specific genes. (PubMed id 17204848)1, 3 Meijer W.H....Kiel J.A. (2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9776 HGNC: 29091 AceView: KIAA0652 Ensembl:ENSG00000175224 euGenes: HUgn9776
    ECgene: ATG13 H-InvDB: ATG13

    (According to HUGE)
    About This Section
    HUGE: KIAA0652

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATG13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ATG13 gene:
    Search GeneIP for patents involving ATG13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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