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Aliases for ATG13 Gene

Aliases for ATG13 Gene

  • Autophagy Related 13 2 3
  • KIAA0652 2 3 4 6
  • PARATARG8 3 6
  • ATG13 Autophagy Related 13 Homolog (S. Cerevisiae) 2
  • ATG13 Autophagy Related 13 Homolog 3
  • Autophagy-Related Protein 13 3

External Ids for ATG13 Gene

Previous HGNC Symbols for ATG13 Gene

  • KIAA0652

Previous GeneCards Identifiers for ATG13 Gene

  • GC11P046345

Summaries for ATG13 Gene

GeneCards Summary for ATG13 Gene

ATG13 (Autophagy Related 13) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy and mTOR signaling pathway. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for ATG13 Gene

  • Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Gene Wiki entry for ATG13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG13 Gene

Genomics for ATG13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATG13 Gene

Start:
46,617,276 bp from pter
End:
46,676,019 bp from pter
Size:
58,744 bases
Orientation:
Plus strand

Genomic View for ATG13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG13 Gene

No data available for Regulatory Elements for ATG13 Gene

Proteins for ATG13 Gene

  • Protein details for ATG13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75143-ATG13_HUMAN
    Recommended name:
    Autophagy-related protein 13
    Protein Accession:
    O75143
    Secondary Accessions:
    • B4DFI4
    • D3DQQ1
    • D3DQQ2
    • E9PQZ8
    • Q53EN6
    • Q9BRL3
    • Q9H8B0

    Protein attributes for ATG13 Gene

    Size:
    517 amino acids
    Molecular mass:
    56572 Da
    Quaternary structure:
    • Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 (via C-terminus). Interacts with ULK2 (via C-terminus). Interacts (via the LIR motif) with GABARAP, GABARAPL, GABARAPL2, and LC3A. Interacts with TAB2 and TAB3.
    SequenceCaution:
    • Sequence=BAA31627.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97323.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATG13 Gene

    Alternative splice isoforms for ATG13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG13 Gene

Proteomics data for ATG13 Gene at MOPED

Post-translational modifications for ATG13 Gene

  • Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ATG13 (ATG13)

No data available for DME Specific Peptides for ATG13 Gene

Domains for ATG13 Gene

Protein Domains for ATG13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75143

UniProtKB/Swiss-Prot:

ATG13_HUMAN :
  • O75143
Domain:
  • The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and LC3A.
Family:
  • Belongs to the ATG13 metazoan family.
genes like me logo Genes that share domains with ATG13: view

No data available for Gene Families for ATG13 Gene

Function for ATG13 Gene

Molecular function for ATG13 Gene

UniProtKB/Swiss-Prot Function: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Gene Ontology (GO) - Molecular Function for ATG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19211835
GO:0019901 protein kinase binding IPI 18936157
genes like me logo Genes that share ontologies with ATG13: view
genes like me logo Genes that share phenotypes with ATG13: view

Animal Model Products

CRISPR Products

miRNA for ATG13 Gene

miRTarBase miRNAs that target ATG13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATG13 Gene

Localization for ATG13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG13 Gene

Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG13 Gene COMPARTMENTS Subcellular localization image for ATG13 gene
Compartment Confidence
cytosol 2
vacuole 2
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ATG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure ISS --
GO:0005739 mitochondrion IDA 21855797
GO:0005829 cytosol IBA --
GO:0034273 ATG1/UKL1 signaling complex IBA --
GO:0070969 ULK1-ATG13-FIP200 complex IPI 19211835
genes like me logo Genes that share ontologies with ATG13: view

Pathways for ATG13 Gene

genes like me logo Genes that share pathways with ATG13: view

Pathways by source for ATG13 Gene

2 BioSystems pathways for ATG13 Gene
1 KEGG pathway for ATG13 Gene

Gene Ontology (GO) - Biological Process for ATG13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IMP 19211835
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with ATG13: view

Transcripts for ATG13 Gene

Unigene Clusters for ATG13 Gene

Autophagy related 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - -
SP12:
SP13: - - - - - - - - - - -
SP14: - -
SP15: - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - - -
SP18:
SP19:
SP20:
SP21: - - - - - - - - - - - - - - -
SP22: - - - - - - -
SP23: - - - - - - - -
SP24: - - - -
SP25: -
SP26: - -
SP27: - - - - - -
SP28: - - - -
SP29:
SP30:
SP31:

ExUns: 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - - -
SP20: -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30: - - - - - - - - - - -
SP31:

Relevant External Links for ATG13 Gene

GeneLoc Exon Structure for
ATG13
ECgene alternative splicing isoforms for
ATG13

Expression for ATG13 Gene

mRNA expression in normal human tissues for ATG13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ATG13 Gene

SOURCE GeneReport for Unigene cluster for ATG13 Gene Hs.127403

genes like me logo Genes that share expressions with ATG13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATG13 Gene

Orthologs for ATG13 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG13 35
  • 97.55 (n)
  • 96.93 (a)
ATG13 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATG13 35
  • 89.86 (n)
  • 93.71 (a)
ATG13 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG13 35
  • 93.7 (n)
  • 98.18 (a)
ATG13 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg13 35
  • 87.09 (n)
  • 91.62 (a)
Atg13 16
Atg13 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATG13 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG13 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg13 35
  • 88.36 (n)
  • 92.81 (a)
chicken
(Gallus gallus)
Aves ATG13 35
  • 83.66 (n)
  • 93.39 (a)
ATG13 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG13 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17897 35
tropical clawed frog
(Silurana tropicalis)
Amphibia atg13 35
  • 71.26 (n)
  • 75.98 (a)
Str.15163 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1013 35
zebrafish
(Danio rerio)
Actinopterygii atg13 35
  • 69.78 (n)
  • 74.55 (a)
atg13 36
  • 76 (a)
OneToOne
zgc63526 35
fruit fly
(Drosophila melanogaster)
Insecta Atg13 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea atg-13 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for ATG13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG13 Gene

ENSEMBL:
Gene Tree for ATG13 (if available)
TreeFam:
Gene Tree for ATG13 (if available)

Paralogs for ATG13 Gene

No data available for Paralogs for ATG13 Gene

Variants for ATG13 Gene

Sequence variations from dbSNP and Humsavar for ATG13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12989 -- 46,674,113(+) CCCTG(C/G)TAAGT utr-variant-3-prime
rs13448 -- 46,673,864(+) GGTGG(C/T)TCTCA utr-variant-3-prime
rs1131306 -- 46,672,968(+) AGGGT(C/T)TGAGC utr-variant-3-prime
rs1131308 -- 46,673,029(+) ATGGC(A/C)CCCTG utr-variant-3-prime
rs1140550 -- 46,672,971(+) GTCTG(A/G)GCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ATG13 Gene

Variant ID Type Subtype PubMed ID
nsv897321 CNV Gain 21882294
esv993220 OTHER Inversion 20482838
nsv38662 CNV Loss 16902084

Relevant External Links for ATG13 Gene

HapMap Linkage Disequilibrium report
ATG13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG13 Gene

Disorders for ATG13 Gene

No disorders were found for ATG13 Gene.

No data available for UniProtKB/Swiss-Prot for ATG13 Gene

Publications for ATG13 Gene

  1. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. (PMID: 23043107) Alemu E.A. … Johansen T. (J. Biol. Chem. 2012) 3 4
  2. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. (PMID: 21855797) Joo J.H. … Kundu M. (Mol. Cell 2011) 3 4
  3. TGFbeta-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy. (PMID: 21976705) Takaesu G. … Yoshimura A. (J. Biochem. 2012) 3 4
  4. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. (PMID: 19225151) Jung C.H. … Kim D.H. (Mol. Biol. Cell 2009) 3 4
  5. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (PMID: 19211835) Hosokawa N. … Mizushima N. (Mol. Biol. Cell 2009) 3 4

Products for ATG13 Gene

  • Addgene plasmids for ATG13

Sources for ATG13 Gene

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