ATG12 Gene
protein-coding GIFtS: 62
GCID: GC05M115195
|
|
autophagy related 12(Previous names: Apg12 (autophagy 12, S. cerevisiae)-like, APG12 autophagy...)
(Previous symbol: APG12L)
| |
Aliases
for ATG12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Autophagy Related 121 2 | | FBR932 | | APG121 2 3 | | HAPG122 | | APG12L1 2 3 | | Apg12 (Autophagy, Yeast) Homolog2 | | Autophagy-Related Protein 122 3 | | ATG12 Autophagy Related 12 Homolog2 | | Apg12 (Autophagy 12, S. Cerevisiae)-Like1 | | Ubiquitin-Like Protein ATG122 | | APG12 Autophagy 12-Like (S. Cerevisiae)1 | | APG12-Like1 | | ATG12 Autophagy Related 12 Homolog (S. Cerevisiae)1 | | |
| External Ids: | HGNC: 5881 | Entrez Gene: 91402 | Ensembl: ENSG000001457827 | OMIM: 6096085 | UniProtKB: O948173 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n409200 | |
Export aliases for ATG12 gene to outside databasesPrevious GC identifer: GC05M110344
Summaries
for ATG12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ATG12:
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosedin double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 isthe human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 (PubMed 9852036)).(supplied byOMIM, Mar 2008)
UniProtKB/Swiss-Prot: ATG12_HUMAN, O94817Function: Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5
Gene Wiki entry for ATG12
|
Genomic Views
for ATG12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ATG12 gene promoter:
ISGF-3 Nkx2-2 CUTL1 LUN-1 Tal-1beta Nkx6-1 FOXJ2 (long isoform) SEF-1 (1) FOXJ2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ATG12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q21-q22 Ensembl cytogenetic band: 5q22.3 HGNC cytogenetic band: 5q21-q22ATG12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M115195: view genomic region
(about GC identifiers)
Start:
|
115,163,893 bp from pter |
End:
|
115,177,555 bp from pter |
Size:
|
13,663 bases |
Orientation:
|
minus strand |
|
Proteins
for ATG12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ATG12_HUMAN, O94817 (See
protein sequence)Recommended Name: Ubiquitin-like protein ATG12 Size: 140 amino acids; 15113 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAH12266.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from  and Proteopedia  for ATG12:4GDK (3D)
4GDL (3D)
Secondary accessions: Q6PJV2Alternative splicing: 2 isoforms: O94817-1 O94817-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ATG12: NX_O94817
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94817
ATG12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004698.3
ENSEMBL proteins: ENSP00000425107 ENSP00000425164 ENSP00000424529 ENSP00000368913 ENSP00000425948 ENSP00000425277 ENSP00000274459 Reactome Protein details: O94817
Human Recombinant Protein Products for ATG12:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ATG12 for ontologies About GeneDecksing
ATG12 Antibody Products:
Assay Products for ATG12: |
Protein
Domains /
Families
for ATG12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ATG12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O94817ProtoNet protein and cluster: O94817 1 Blocks protein family: IPB007242 Autophagy protein Apg12
UniProtKB/Swiss-Prot: ATG12_HUMAN, O94817Domain: Shares weak sequence similarity with ubiquitin family, but contains an 'ubiquitin superfold' and the C-terminalGly is required for isopeptide linkageSimilarity: Belongs to the ATG12 family |
Function
for ATG12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ATG12_HUMAN, O94817Function: Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5 Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
ATG12 for ontologies About GeneDecksing
Phenotypes:
6 GenomeRNAi human phenotypes for ATG12:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG12 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ATG12 (NM_004707) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATG12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG12 |
|
Pathways & Interactions
for ATG12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | | | 2 | Immune System | | | 3 | Protein Stability | | | 4 | Glucose / Energy Metabolism | | | 5 | Apoptosis and Autophagy | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Cell Signaling Technology (CST) Pathways for ATG12
4 
Reactome Pathways for ATG12
2 
Kegg Pathways (Kegg details for ATG12):
ATG12 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ATG12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/263 Interacting proteins for ATG12 (O948172, 3 ENSP000002744594) via UniProtKB, MINT, STRING, and/or I2D (see all 263)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000045 | autophagic vacuole assembly |
ISS | -- | | GO:0006914 | autophagy |
-- | -- | | GO:0032480 | negative regulation of type I interferon production |
TAS | -- | | GO:0045087 | innate immune response |
TAS | -- |
ATG12 for ontologies About GeneDecksing
|
Drugs & Compounds
for ATG12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ATG12
Search CenterWatch for drugs/clinical trials and news about ATG12
|
Transcripts
for ATG12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ATG12 gene: NM_004707.3 Unigene Cluster for ATG12: Autophagy related 12 Hs.264482 [show with all ESTs]Unigene Representative Sequence: NR_03336214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000509910 ENST00000505252 ENST00000500945 ENST00000507793 ENST00000513292
ENST00000508464 ENST00000513322 ENST00000511984 ENST00000379594 ENST00000509598
ENST00000505993 ENST00000513167 ENST00000514775 ENST00000274459(uc021ycr.1 uc021ycs.1 uc003krh.3 uc003kri.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG12 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ATG12 (NM_004707) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ATG12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG12 |
Additional cDNA sequence: AB002440.1 AB002449.2 AB017507.1 AK313320.1 BC011033.1 BC012266.2 EU554057.1 NR_033362.1 NR_033363.1 19 DOTS entries: DT.100680580 DT.446145 DT.215928 DT.92419910 DT.92048590 DT.101962391 DT.120806551 DT.100811754 DT.95259664 DT.120806525 DT.92419909 DT.100779296 DT.100779295 DT.120806511 DT.303883 DT.97858960 DT.100802593 DT.100810712 DT.120806520 24/270 AceView cDNA sequences (see all 270): CA394993 R77916 BF591297 BX507876 NM_004707 BE048814 BX366186 BX091721 BQ086311 BU735748 CF541272 AI860901 BG163489 AW188881 BQ632371 AL518404 AW024377 AI589158 BQ014838 CR608587 N91468 AA460065 BU633475 AI245625
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ATG12 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | · | 8g | · | 8h |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ATG12
|
Expression
for ATG12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ATG12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCTTACA
About this image
See ATG12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ATG12
SOURCE GeneReport for Unigene cluster: Hs.264482
UniProtKB/Swiss-Prot: ATG12_HUMAN, O94817Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including ATG12:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ATG12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG12 |
Orthologs
for ATG12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ATG12 gene from 8/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Atg121 , 5 |
autophagy-related 12 (yeast)5
autophagy related 121 |
85.48(n)1
89.29(a)1 |
|
18 (24.76 cM)5
675261 NM_026217.31 NP_080493.21
467324175 |
chicken
(Gallus gallus) |
Aves |
ATG121 |
ATG12 autophagy related 12 homolog (S. cerevisiae) |
71.22(n)
76.98(a) |
|
427390 XM_424963.3 XP_424963.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ATG126 |
-- |
73(a) |
1 ↔ 1 |
GL343193.1(8388247-8392975) |
zebrafish
(Danio rerio) |
Actinopterygii |
ddah12 |
dimethylarginine dimethylaminohydrolase 1 |
78.5(n) |
|
BM037383.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Atg121 |
Autophagy-specific gene 12 |
54.52(n)
55.14(a) |
|
39383 NM_140294.3 NP_648551.3 |
worm
(Caenorhabditis elegans) |
Secernentea |
lgg-36 |
LC3, GABARAP and GATE-16 family member (lgg-3) |
31(a) |
1 ↔ 1 |
III(5697431-5697964) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
APG126ATG12A6 |
ubiquitin-like protein ATG12A |
44(a)42(a) |
many → 1many → 1 |
3(4613506-4614848) 1(20241226-20242615) |
rice
(Oryza sativa) |
Liliopsida |
-- |
autophagy-related protein 12, putative, expressed |
34(a) |
1 ↔ 1 |
6(5307993-5309603) |
ENSEMBL Gene Tree for ATG12 (if available)
TreeFam Gene Tree for ATG12 (if available) |
Paralogs
for ATG12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ATG12 gene
ATG12 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ATG12
PGOHUM00000237173 PGOHUM00000250451
|
Genomic Variants
for ATG12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ATG12 (115163893 - 115177555 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ATG12
2 CNVs: 93199 93200 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG12 |
|
Disorders
/ Diseases
for ATG12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ATG12 for disorders About GeneDecksing
OMIM gene information: 609608
OMIM disorders: --
10  diseases for ATG12: About MalaCardsinclusion body myositis acute myeloid leukemia myositis myeloid leukemia
myelodysplastic syndrome colorectal cancer leukemia lung cancer
retinitis carcinoma
Human Genome Epidemiology (HuGE) Navigator: ATG12 (2 documents)
Export disorders for ATG12 gene to outside databases
|
Publications
for ATG12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ATG12 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with ATG12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. (PubMed id 9852036)1, 2, 3 Mizushima N.... Ohsumi Y. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. (PubMed id 19197948)1, 9 Kang M.R....Lee S.H. (2009)
- The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. (PubMed id 18704115)2, 9 Geng J. and Klionsky D.J. (2008)
- Regulation of autophagy by the p300 acetyltransferase. (PubMed id 19124466)1, 9 Lee I.H. and Finkel T. (2009)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. (PubMed id 22342342)1 Chen D.... Zhong Q. (2012)
- Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan. (PubMed id 22170153)1 Mai S....Jendrach M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
|
External Searches for ATG12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ATG12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ATG12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ATG12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ATG12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ATG12 gene:
Search GeneIP for patents involving ATG12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ATG12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for ATG12 | | OriGene shRNA RFP for ATG12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ATG12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ATG12 | | | OriGene Protein Over-expression Lysate for ATG12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ATG12 | | OriGene 3'-UTR Clone for ATG12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ATG12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ATG12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ATG12 | | OriGene Custom Protein Services for ATG12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ATG12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ATG12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATG12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ATG12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ATG12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ATG12 |
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| | | | Search Tocris compounds for ATG12 |
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 | | | ATG12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG12 |
|  |  |  |  | | | | ThermoFisher Antibody for ATG12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG12 |
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