Aliases for ATG12 Gene
External Ids for ATG12 Gene
Previous HGNC Symbols for ATG12 Gene
Previous GeneCards Identifiers for ATG12 Gene
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ATG12 Gene
ATG12 (Autophagy Related 12) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway and Cellular Senescence (REACTOME). GO annotations related to this gene include Atg8 ligase activity.
UniProtKB/Swiss-Prot for ATG12 Gene
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.