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Aliases for ATG101 Gene

Aliases for ATG101 Gene

  • Autophagy Related 101 2 3
  • C12orf44 3 4 6
  • Chromosome 12 Open Reading Frame 44 2
  • Autophagy-Related Protein 101 3
  • Atg13-Interacting Protein 3

External Ids for ATG101 Gene

Previous HGNC Symbols for ATG101 Gene

  • C12orf44

Previous GeneCards Identifiers for ATG101 Gene

  • GC12P052464

Summaries for ATG101 Gene

GeneCards Summary for ATG101 Gene

ATG101 (Autophagy Related 101) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ATG101 Gene

  • Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.

Gene Wiki entry for ATG101 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG101 Gene

Genomics for ATG101 Gene

Genomic Location for ATG101 Gene

52,069,246 bp from pter
52,077,495 bp from pter
8,250 bases
Plus strand

Genomic View for ATG101 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG101 Gene

No data available for Regulatory Elements for ATG101 Gene

Proteins for ATG101 Gene

  • Protein details for ATG101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Autophagy-related protein 101
    Protein Accession:
    Secondary Accessions:
    • Q9HAE2
    • Q9HBN1

    Protein attributes for ATG101 Gene

    218 amino acids
    Molecular mass:
    25003 Da
    Quaternary structure:
    • Interacts with ATG13. Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13.
    • Sequence=AAG17273.1; Type=Frameshift; Positions=110; Evidence={ECO:0000305};

neXtProt entry for ATG101 Gene

Proteomics data for ATG101 Gene at MOPED

Post-translational modifications for ATG101 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG101 Gene

No data available for DME Specific Peptides for ATG101 Gene

Domains for ATG101 Gene

Protein Domains for ATG101 Gene


Suggested Antigen Peptide Sequences for ATG101 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BSB4
  • Belongs to the ATG101 family.
genes like me logo Genes that share domains with ATG101: view

No data available for Gene Families for ATG101 Gene

Function for ATG101 Gene

Molecular function for ATG101 Gene

UniProtKB/Swiss-Prot Function: Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.

Gene Ontology (GO) - Molecular Function for ATG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
GO:0032403 protein complex binding IPI 19597335
GO:0042802 identical protein binding IPI 20562859
genes like me logo Genes that share ontologies with ATG101: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ATG101 Gene

Localization for ATG101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG101 Gene

Cytoplasm. Preautophagosomal structure. Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.

Gene Ontology (GO) - Cellular Components for ATG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IDA 19597335
genes like me logo Genes that share ontologies with ATG101: view

No data available for Subcellular locations from COMPARTMENTS for ATG101 Gene

Pathways for ATG101 Gene

SuperPathways for ATG101 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ATG101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IMP 19597335
genes like me logo Genes that share ontologies with ATG101: view

No data available for Pathways by source for ATG101 Gene

Transcripts for ATG101 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ATG101 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for ATG101 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG101 Gene

mRNA expression in normal human tissues for ATG101 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATG101 Gene

genes like me logo Genes that share expressions with ATG101: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATG101 Gene

Orthologs for ATG101 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG101 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C12H12orf44 35
  • 99.69 (n)
  • 100 (a)
C12orf44 36
  • 100 (a)
(Bos Taurus)
Mammalia ATG101 36
  • 99 (a)
C5H12orf44 35
  • 93.12 (n)
  • 99.08 (a)
(Canis familiaris)
Mammalia C12ORF44 36
  • 99 (a)
C27H12orf44 35
  • 92.05 (n)
  • 99.54 (a)
(Mus musculus)
Mammalia 9430023L20Rik 35
  • 91.13 (n)
  • 98.62 (a)
9430023L20Rik 16
9430023L20Rik 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1359310 35
  • 91.44 (n)
  • 98.17 (a)
(Anolis carolinensis)
Reptilia C12orf44 36
  • 94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11635 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf44 35
  • 78.13 (n)
  • 91.28 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8586 35
(Danio rerio)
Actinopterygii atg101 35
  • 80.12 (n)
  • 87.16 (a)
C10H12orf44 36
  • 87 (a)
Dr.12242 35
fruit fly
(Drosophila melanogaster)
Insecta CG7053 35
  • 61.77 (n)
  • 50.92 (a)
CG7053 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y69A2AR.7 35
  • 51.28 (n)
  • 38.97 (a)
epg-9 36
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11146 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9278 36
  • 50 (a)
Species with no ortholog for ATG101:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG101 Gene

Gene Tree for ATG101 (if available)
Gene Tree for ATG101 (if available)

Paralogs for ATG101 Gene

Selected SIMAP similar genes for ATG101 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATG101: view

No data available for Paralogs for ATG101 Gene

Variants for ATG101 Gene

Sequence variations from dbSNP and Humsavar for ATG101 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11521 -- 52,077,375(+) GCTGA(C/T)GGTTC utr-variant-3-prime
rs1283162 -- 52,077,607(+) GGTGG(A/G)TGGGA downstream-variant-500B
rs1283163 -- 52,077,254(+) GCACT(A/T)TTGGG utr-variant-3-prime
rs1283164 -- 52,075,431(-) tgcac(A/G)caccc intron-variant
rs1283165 -- 52,073,216(-) ACAGG(A/G)TGGGA intron-variant

Relevant External Links for ATG101 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ATG101 Gene

Disorders for ATG101 Gene

No disorders were found for ATG101 Gene.

No data available for UniProtKB/Swiss-Prot for ATG101 Gene

Publications for ATG101 Gene

  1. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PMID: 19287211) Mercer C.A. … Dennis P.B. (Autophagy 2009) 2 3 4
  2. Atg101, a novel mammalian autophagy protein interacting with Atg13. (PMID: 19597335) Hosokawa N. … Mizushima N. (Autophagy 2009) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3

Products for ATG101 Gene

Sources for ATG101 Gene

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