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Aliases for ATG101 Gene

Aliases for ATG101 Gene

  • Autophagy Related 101 2 3 5
  • C12orf44 3 4
  • Chromosome 12 Open Reading Frame 44 2
  • Atg13-Interacting Protein 3

External Ids for ATG101 Gene

Previous HGNC Symbols for ATG101 Gene

  • C12orf44

Previous GeneCards Identifiers for ATG101 Gene

  • GC12P052464

Summaries for ATG101 Gene

GeneCards Summary for ATG101 Gene

ATG101 (Autophagy Related 101) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Longevity regulating pathway - multiple species. GO annotations related to this gene include identical protein binding and protein complex binding.

UniProtKB/Swiss-Prot for ATG101 Gene

  • Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.

Gene Wiki entry for ATG101 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG101 Gene

Genomics for ATG101 Gene

Regulatory Elements for ATG101 Gene

Enhancers for ATG101 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ATG101 on UCSC Golden Path with GeneCards custom track

Promoters for ATG101 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ATG101 on UCSC Golden Path with GeneCards custom track

Genomic Location for ATG101 Gene

52,069,246 bp from pter
52,077,495 bp from pter
8,250 bases
Plus strand

Genomic View for ATG101 Gene

Genes around ATG101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG101 Gene

Proteins for ATG101 Gene

  • Protein details for ATG101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Autophagy-related protein 101
    Protein Accession:
    Secondary Accessions:
    • Q9HAE2
    • Q9HBN1

    Protein attributes for ATG101 Gene

    218 amino acids
    Molecular mass:
    25003 Da
    Quaternary structure:
    • Interacts with ATG13. Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13.
    • Sequence=AAG17273.1; Type=Frameshift; Positions=110; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ATG101 Gene

neXtProt entry for ATG101 Gene

Proteomics data for ATG101 Gene at MOPED

Post-translational modifications for ATG101 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ATG101 Gene

No data available for DME Specific Peptides for ATG101 Gene

Domains & Families for ATG101 Gene

Gene Families for ATG101 Gene

Protein Domains for ATG101 Gene


Suggested Antigen Peptide Sequences for ATG101 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATG101 family.
  • Belongs to the ATG101 family.
genes like me logo Genes that share domains with ATG101: view

Function for ATG101 Gene

Molecular function for ATG101 Gene

UniProtKB/Swiss-Prot Function:
Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.
genes like me logo Genes that share phenotypes with ATG101: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ATG101 Gene

Localization for ATG101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG101 Gene

Cytoplasm. Preautophagosomal structure. Note=Under starvation conditions, it is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ATG101 Gene

Pathways & Interactions for ATG101 Gene

genes like me logo Genes that share pathways with ATG101: view

Pathways by source for ATG101 Gene

1 GeneTex pathway for ATG101 Gene
2 Reactome pathways for ATG101 Gene
1 KEGG pathway for ATG101 Gene

SIGNOR curated interactions for ATG101 Gene


Gene Ontology (GO) - Biological Process for ATG101 Gene


Drugs & Compounds for ATG101 Gene

No Compound Related Data Available

Transcripts for ATG101 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ATG101 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for ATG101 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ATG101 Gene

mRNA expression in normal human tissues for ATG101 Gene

Protein differential expression in normal tissues from HIPED for ATG101 Gene

This gene is overexpressed in Brain (17.8), Peripheral blood mononuclear cells (13.5), and Frontal cortex (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATG101 Gene

genes like me logo Genes that share expression patterns with ATG101: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ATG101 Gene

Orthologs for ATG101 Gene

This gene was present in the common ancestor of animals.

Orthologs for ATG101 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C5H12orf44 35
  • 93.12 (n)
  • 99.08 (a)
ATG101 36
  • 99 (a)
(Canis familiaris)
Mammalia C27H12orf44 35
  • 92.05 (n)
  • 99.54 (a)
C12ORF44 36
  • 99 (a)
(Mus musculus)
Mammalia 9430023L20Rik 35
  • 91.13 (n)
  • 98.62 (a)
Atg101 16
9430023L20Rik 36
  • 99 (a)
(Pan troglodytes)
Mammalia C12H12orf44 35
  • 99.69 (n)
  • 100 (a)
C12orf44 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1359310 35
  • 91.44 (n)
  • 98.17 (a)
(Anolis carolinensis)
Reptilia C12orf44 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf44 35
  • 78.13 (n)
  • 91.28 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11635 35
(Danio rerio)
Actinopterygii atg101 35
  • 80.12 (n)
  • 87.16 (a)
Dr.12242 35
C10H12orf44 36
  • 87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8586 35
fruit fly
(Drosophila melanogaster)
Insecta CG7053 35
  • 61.77 (n)
  • 50.92 (a)
CG7053 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y69A2AR.7 35
  • 51.28 (n)
  • 38.97 (a)
epg-9 36
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11146 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9278 36
  • 50 (a)
Species with no ortholog for ATG101:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG101 Gene

Gene Tree for ATG101 (if available)
Gene Tree for ATG101 (if available)

Paralogs for ATG101 Gene

(1) SIMAP similar genes for ATG101 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ATG101: view

No data available for Paralogs for ATG101 Gene

Variants for ATG101 Gene

Sequence variations from dbSNP and Humsavar for ATG101 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11521 -- 52,077,375(+) GCTGA(C/T)GGTTC utr-variant-3-prime
rs7138000 -- 52,076,325(+) AAAAG(C/G)AAGGA intron-variant
rs10876230 -- 52,072,398(+) TGATT(C/T)GCTTA intron-variant
rs10876231 -- 52,072,421(+) AAGAT(A/G)TAGAT intron-variant
rs10876232 -- 52,072,572(+) ACCCT(A/G)GAGTC intron-variant

Variation tolerance for ATG101 Gene

Residual Variation Intolerance Score: 26.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ATG101 Gene

Disorders for ATG101 Gene

Relevant External Links for ATG101

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ATG101 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG101 Gene

Publications for ATG101 Gene

  1. Atg101, a novel mammalian autophagy protein interacting with Atg13. (PMID: 19597335) Hosokawa N. … Mizushima N. (Autophagy 2009) 2 3 4 67
  2. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. (PMID: 19287211) Mercer C.A. … Dennis P.B. (Autophagy 2009) 2 3
  3. FIP200 regulates targeting of Atg16L1 to the isolation membrane. (PMID: 23392225) Nishimura T. … Mizushima N. (EMBO Rep. 2013) 3
  4. Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism. (PMID: 23640897) Wang N. … Laurie G.W. (J. Biol. Chem. 2013) 3
  5. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. (PMID: 24100292) Fujita N. … Yoshimori T. (J. Cell Biol. 2013) 3

Products for ATG101 Gene

Sources for ATG101 Gene