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Aliases for ATG10 Gene

Aliases for ATG10 Gene

  • Autophagy Related 10 2 3
  • Autophagy-Related Protein 10 3 4
  • APG10L 3 4
  • APG10 3 6
  • ATG10 Autophagy Related 10 Homolog (S. Cerevisiae) 2
  • APG10 Autophagy 10-Like (S. Cerevisiae) 2
  • Ubiquitin-Like-Conjugating Enzyme ATG10 3
  • ATG10 Autophagy Related 10 Homolog 3
  • APG10-Like 4
  • EC 6.3.2.- 4
  • Pp12616 3

External Ids for ATG10 Gene

Previous HGNC Symbols for ATG10 Gene

  • APG10L

Previous GeneCards Identifiers for ATG10 Gene

  • GC05P081304
  • GC05P081267
  • GC05P076475

Summaries for ATG10 Gene

Entrez Gene Summary for ATG10 Gene

  • Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ATG10 Gene

ATG10 (Autophagy Related 10) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy and Regulation of autophagy. GO annotations related to this gene include Atg12 transferase activity.

UniProtKB/Swiss-Prot for ATG10 Gene

  • E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.

Gene Wiki entry for ATG10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG10 Gene

Genomics for ATG10 Gene

Regulatory Elements for ATG10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ATG10 Gene

Start:
81,972,025 bp from pter
End:
82,276,857 bp from pter
Size:
304,833 bases
Orientation:
Plus strand

Genomic View for ATG10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ATG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG10 Gene

Proteins for ATG10 Gene

  • Protein details for ATG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0Y0-ATG10_HUMAN
    Recommended name:
    Ubiquitin-like-conjugating enzyme ATG10
    Protein Accession:
    Q9H0Y0
    Secondary Accessions:
    • B2RE09
    • Q6PIX1
    • Q9H842

    Protein attributes for ATG10 Gene

    Size:
    220 amino acids
    Molecular mass:
    25279 Da
    Quaternary structure:
    • Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity). Interacts with IRGM.
    SequenceCaution:
    • Sequence=BC004551; Type=Frameshift; Positions=26; Evidence={ECO:0000305}; Sequence=BC027718; Type=Frameshift; Positions=26; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG10 Gene

Proteomics data for ATG10 Gene at MOPED

Post-translational modifications for ATG10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ATG10 Gene

Domains for ATG10 Gene

Protein Domains for ATG10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0Y0

UniProtKB/Swiss-Prot:

ATG10_HUMAN :
  • Q9H0Y0
Family:
  • Belongs to the ATG10 family.
genes like me logo Genes that share domains with ATG10: view

No data available for Gene Families for ATG10 Gene

Function for ATG10 Gene

Molecular function for ATG10 Gene

UniProtKB/Swiss-Prot Function: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.

Enzyme Numbers (IUBMB) for ATG10 Gene

Gene Ontology (GO) - Molecular Function for ATG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0016874 ligase activity IEA --
GO:0019777 Atg12 transferase activity ISS 20723759
genes like me logo Genes that share ontologies with ATG10: view

Animal Model Products

CRISPR Products

miRNA for ATG10 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ATG10 Gene

Localization for ATG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG10 Gene COMPARTMENTS Subcellular localization image for ATG10 gene
Compartment Confidence
cytosol 3
nucleus 2
vacuole 2
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ATG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ATG10: view

Pathways for ATG10 Gene

genes like me logo Genes that share pathways with ATG10: view

Pathways by source for ATG10 Gene

1 BioSystems pathway for ATG10 Gene
1 KEGG pathway for ATG10 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ATG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006497 protein lipidation ISS --
GO:0006914 autophagy IMP 15657430
GO:0015031 protein transport IEA --
GO:0031401 positive regulation of protein modification process ISS --
GO:0032446 protein modification by small protein conjugation IDA 16963840
genes like me logo Genes that share ontologies with ATG10: view

Transcripts for ATG10 Gene

Unigene Clusters for ATG10 Gene

Autophagy related 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ATG10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG10 Gene

No ASD Table

Relevant External Links for ATG10 Gene

GeneLoc Exon Structure for
ATG10
ECgene alternative splicing isoforms for
ATG10

Expression for ATG10 Gene

mRNA expression in normal human tissues for ATG10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ATG10 Gene

SOURCE GeneReport for Unigene cluster for ATG10 Gene Hs.713698

genes like me logo Genes that share expressions with ATG10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATG10 Gene

Orthologs for ATG10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATG10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG10 35
  • 99.54 (n)
  • 99.54 (a)
ATG10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ATG10 35
  • 88.74 (n)
  • 84.93 (a)
MGC138057 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG10 35
  • 88.28 (n)
  • 84.47 (a)
ATG10 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Atg10 35
  • 83.81 (n)
  • 81.9 (a)
Atg10 16
Atg10 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATG10 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ATG10 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atg10 35
  • 82.79 (n)
  • 79.34 (a)
chicken
(Gallus gallus)
Aves ATG10 35
  • 65.44 (n)
  • 61.93 (a)
ATG10 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ATG10 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg10 35
  • 61.35 (n)
  • 56.04 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5721 35
zebrafish
(Danio rerio)
Actinopterygii atg10 35
  • 53.9 (n)
  • 54.23 (a)
atg10 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12821 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea atg-10 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG10 35
  • 46.52 (n)
  • 42.54 (a)
Species with no ortholog for ATG10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG10 Gene

ENSEMBL:
Gene Tree for ATG10 (if available)
TreeFam:
Gene Tree for ATG10 (if available)

Paralogs for ATG10 Gene

No data available for Paralogs for ATG10 Gene

Variants for ATG10 Gene

Sequence variations from dbSNP and Humsavar for ATG10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs170509 -- 82,114,094(+) CTGTG(A/T)TGTAA intron-variant
rs178957 -- 82,120,486(+) AAACT(A/G)TAGAA intron-variant
rs184454 -- 82,110,366(+) tgagg(A/C)attgc intron-variant
rs189788 -- 82,100,772(+) ACTAG(G/T)ttttt intron-variant
rs324902 -- 82,110,661(+) tttct(G/T)gtaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG10 Gene

Variant ID Type Subtype PubMed ID
nsv471018 CNV Gain 18288195
esv2752082 CNV Gain 17911159
dgv1815e1 CNV Complex 17122850
esv2669720 CNV Deletion 23128226
nsv328970 CNV Insertion 16902084
essv21771 CNV CNV 17122850
esv2730388 CNV Deletion 23290073
esv270429 CNV Insertion 20981092
esv2730389 CNV Deletion 23290073
nsv821002 CNV Duplication 20802225
nsv10712 CNV Loss 18304495
esv25341 CNV Loss 19812545
esv1267942 CNV Deletion 17803354
nsv830364 CNV Loss 17160897
esv2730390 CNV Deletion 23290073
nsv520938 CNV Gain 19592680

Relevant External Links for ATG10 Gene

HapMap Linkage Disequilibrium report
ATG10
Human Gene Mutation Database (HGMD)
ATG10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG10 Gene

Disorders for ATG10 Gene

Relevant External Links for ATG10

Genetic Association Database (GAD)
ATG10
Human Genome Epidemiology (HuGE) Navigator
ATG10
genes like me logo Genes that share disorders with ATG10: view

No data available for UniProtKB/Swiss-Prot for ATG10 Gene

Publications for ATG10 Gene

  1. Regulation of autophagy by the inositol trisphosphate receptor. (PMID: 17256008) Criollo A. … Kroemer G. (Cell Death Differ. 2007) 3 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Inhibition of macroautophagy triggers apoptosis. (PMID: 15657430) Boya P. … Kroemer G. (Mol. Cell. Biol. 2005) 3 23
  4. Stimulation of ATG12-ATG5 conjugation by ribonucleic acid. (PMID: 16963840) Shao Y. … Jiang X. (Autophagy 2007) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ATG10 Gene

Sources for ATG10 Gene

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