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ATG10 Gene

protein-coding   GIFtS: 54
GCID: GC05P081267

Autophagy Related 10

(Previous names: APG10 autophagy 10-like (S. cerevisiae), ATG10 autophagy...)
(Previous symbol: APG10L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Autophagy Related 101 2     ATG10 Autophagy Related 10 Homolog2
APG10L1 2 3     pp126162
Autophagy-Related Protein 102 3     Ubiquitin-Like-Conjugating Enzyme ATG102
APG102 5     APG10-like3
APG10 Autophagy 10-Like (S. Cerevisiae)1     EC 6.3.2.-3
ATG10 Autophagy Related 10 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 203151   Entrez Gene: 837342   Ensembl: ENSG000001523487   OMIM: 6108005   UniProtKB: Q9H0Y03   
ORGUL members:         

Export aliases for ATG10 gene to outside databases

Previous GC identifers: GC05P081304 GC05P076475


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ATG10 Gene:
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme
involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM
604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast
Apg8, to a membrane-bound form (Nemoto et al., 2003 (PubMed 12890687)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ATG10 Gene:
ATG10 (autophagy related 10) is a protein-coding gene. Diseases associated with ATG10 include myelodysplastic syndromes, and acute myeloid leukemia. GO annotations related to this gene include Atg12 ligase activity.

UniProtKB/Swiss-Prot: ATG10_HUMAN, Q9H0Y0
Function: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12
to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not
involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis

Gene Wiki entry for ATG10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ATG10 gene promoter:
         Egr-3   Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   Nkx3-1 v2   HFH-1   Nkx3-1 v3   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidATG10 promoter sequence
   Search Chromatin IP Primers for ATG10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ATG10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.1   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

ATG10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATG10 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P081267:  view genomic region     (about GC identifiers)

Start:
81,267,844 bp from pter      End:
81,572,676 bp from pter
Size:
304,833 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ATG10_HUMAN, Q9H0Y0 (See protein sequence)
Recommended Name: Ubiquitin-like-conjugating enzyme ATG10  
Size: 220 amino acids; 25279 Da
Subunit: Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to
ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity). Interacts with IRGM
Sequence caution: Sequence=BC004551; Type=Frameshift; Positions=26; Sequence=BC027718; Type=Frameshift;
Positions=26;
Secondary accessions: B2RE09 Q6PIX1 Q9H842
Alternative splicing: 2 isoforms:  Q9H0Y0-1   Q9H0Y0-2   

Explore the universe of human proteins at neXtProt for ATG10: NX_Q9H0Y0

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (2 alternative transcripts): 
    NP_001124500.1  NP_113670.1  

    ENSEMBL proteins: 
     ENSP00000347309   ENSP00000282185   ENSP00000422340   ENSP00000404938   ENSP00000425182  
     ENSP00000424236   ENSP00000425225  

    ATG10 Human Recombinant Protein Products:

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    Novus Biologicals ATG10 Proteins
    Novus Biologicals ATG10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ATG10
    Cloud-Clone Corp. Proteins for ATG10

    ATG10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ATG10
    R&D Systems Antibodies for ATG10
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    Abcam antibodies for ATG10
    Cloud-Clone Corp. Antibodies for ATG10
    ThermoFisher Antibodies for ATG10
    LSBio Antibodies in human, mouse, rat for ATG10

    ATG10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ATG10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ATG10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ATG10
    Cloud-Clone Corp. CLIAs for ATG10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007135 Autophagy-rel_prot_3

    Graphical View of Domain Structure for InterPro Entry Q9H0Y0

    ProtoNet protein and cluster: Q9H0Y0

    UniProtKB/Swiss-Prot: ATG10_HUMAN, Q9H0Y0
    Similarity: Belongs to the ATG10 family


    ATG10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATG10_HUMAN, Q9H0Y0
    Function: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12
    to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not
    involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019777Atg12 ligase activity ISS--
         
    ATG10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ATG10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ATG10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ATG10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ATG10

    miRNA
    Products:
        
    miRTarBase miRNAs that target ATG10:
    hsa-mir-9-5p (MIRT021335), hsa-mir-192-5p (MIRT026156), hsa-mir-215-5p (MIRT024684), hsa-mir-181a-5p (MIRT025071)

    Block miRNA regulation of human, mouse, rat ATG10 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ATG10:
    hsa-miR-1266 hsa-miR-625* hsa-miR-18b* hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidATG10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ATG10
    Predesigned siRNA for gene silencing in human, mouse, rat ATG10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ATG10

    Clone
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    OriGene clones in human, mouse for ATG10 (see all 14)
    OriGene ORF clones in mouse, rat for ATG10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATG10 (NM_001131028)
    Sino Biological Human cDNA Clone for ATG10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG10

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ATG10
    Browse ESI BIO Cell Lines and PureStem Progenitors for ATG10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATG10_HUMAN, Q9H0Y0: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    vacuole2
    extracellular1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IEA--

    ATG10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ATG10 About    
    See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy
    2Regulation of autophagy
    Regulation of autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ATG10
        Senescence and Autophagy



    1 Kegg Pathway  (Kegg details for ATG10):
        Regulation of autophagy


    ATG10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ATG10: 
              Autophagy in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ATG10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ATG10 (Q9H0Y01, 3 ENSP000002821854) via UniProtKB, MINT, STRING, and/or I2D (see all 411)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006497protein lipidation ISS--
    GO:0006914autophagy IMP15657430
    GO:0015031protein transport IEA--
    GO:0031401positive regulation of protein modification process ISS--
    GO:0032446protein modification by small protein conjugation IDA16963840

    ATG10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ATG10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ATG10 gene (2 alternative transcripts): 
    NM_001131028.1  NM_031482.4  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355178(uc003khq.2) ENST00000282185(uc003khs.3 uc003khr.3 uc010jas.3)
    ENST00000510085 ENST00000458350 ENST00000513443 ENST00000504770 ENST00000513634
    ENST00000508814 ENST00000514253
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ATG10 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ATG10:
    hsa-miR-1266 hsa-miR-625* hsa-miR-18b* hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidATG10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ATG10
    Predesigned siRNA for gene silencing in human, mouse, rat ATG10
    Clone
    Products:
         
    OriGene clones in human, mouse for ATG10 (see all 14)
    OriGene ORF clones in mouse, rat for ATG10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ATG10 (NM_001131028)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ATG10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ATG10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ATG10
    OriGene qSTAR qPCR primer pairs in human, mouse for ATG10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG10
      QuantiTect SYBR Green Assays in human, mouse, rat ATG10
      QuantiFast Probe-based Assays in human, mouse, rat ATG10

    Selected AceView cDNA sequences (see all 67):

    AI278996 AI436652 AA806636 BE783934 AA448080 AK024016 BX104068 BQ420338 
    BG025165 AI277752 AI313392 AU142946 BE901981 BC004551 BC027718 BU164085 
    BX399138 CK005009 AF318326 AL136912 BV204805 AI027990 BV204796 BI667565 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ATG10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATTGAGG
    ATG10 Expression
    About this image

    ATG10 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
        Pathway & Disease-focused RT2 Profiler PCR Array including ATG10: 
              Autophagy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ATG10
    OriGene qSTAR qPCR primer pairs in human, mouse for ATG10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ATG10
    QuantiTect SYBR Green Assays in human, mouse, rat ATG10
    QuantiFast Probe-based Assays in human, mouse, rat ATG10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ATG10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ATG10 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Atg101 , 5 autophagy-related 10 (yeast)5
    autophagy related 101
    83.81(n)1
    81.9(a)1
      13 (46.46 cM)5
    667951  NM_025770.31  NP_080046.31 
     909353495 
    chicken
    (Gallus gallus)
    Aves ATG101 autophagy related 10 65.44(n)
    61.93(a)
      427322  XM_424902.3  XP_424902.2 
    lizard
    (Anolis carolinensis)
    Reptilia ATG106
    autophagy related 10
    60(a)
    1 ↔ 1
    2(17831214-17959106)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia atg101 autophagy related 10 61.35(n)
    56.04(a)
      100492117  XM_004910886.1  XP_004910943.1 
    zebrafish
    (Danio rerio)
    Actinopterygii atg101 ATG10 autophagy related 10 homolog (S. cerevisiae) 53.9(n)
    54.23(a)
      641330  NM_001037124.1  NP_001032201.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG128216
    --
    23(a)
    1 ↔ 1
    2R(3719676-3723579)
    worm
    (Caenorhabditis elegans)
    Secernentea atg-106
    Protein ATG-10 (atg-10) mRNA, complete cds
    25(a)
    1 ↔ 1
    II(8659133-8659800) WBGene00008427
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATG101 ATG10 46.52(n)
    42.54(a)
      819941  NM_180202.1  NP_850533.1 


    ENSEMBL Gene Tree for ATG10 (if available)
    TreeFam Gene Tree for ATG10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ATG10 (see all 4411)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836913421,2
    --81265882(+) GGGTCC/TCGCCC 2 -- us2k10--------
    rs1441896231,2
    --81265914(+) CATGCC/TCAGAG 2 -- us2k10--------
    rs1486603731,2
    C--81265985(+) TTAGAG/TCATAC 2 -- us2k10--------
    rs778579871,2
    C--81266001(+) TGTCCA/CATCAT 2 -- us2k10--------
    rs1421816961,2
    --81266026(+) GTCCAC/TACTTT 2 -- us2k10--------
    rs1891805251,2
    --81266069(+) CTGTAC/TCTTTG 2 -- us2k10--------
    rs47035331,2
    C,A,H--81266197(+) AGCTAC/GAGGAG 2 -- us2k17Minor allele frequency- G:0.46NA WA EA 366
    rs100366531,2
    C,F,H--81266382(+) TGTGAA/TTTATG 2 -- us2k1 tfbs39Minor allele frequency- T:0.24NS EA NA 648
    rs1163317801,2
    C,F--81266468(+) ATATGG/CAGTAC 2 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1466871371,2
    --81266473(+) GAGTAC/TAATGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ATG10 (81267844 - 81517844 bp, first 250kb of ATG10)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ATG10 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730389CNV Deletion23290073
    esv2730390CNV Deletion23290073
    esv1267942CNV Deletion17803354
    esv2669720CNV Deletion23128226
    esv2730388CNV Deletion23290073
    nsv821002CNV Duplication20802225
    nsv328970CNV Insertion16902084
    esv270429CNV Insertion20981092
    nsv10712CNV Loss18304495
    nsv830364CNV Loss17160897

    Human Gene Mutation Database (HGMD): ATG10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ATG10
    DNA2.0 Custom Variant and Variant Library Synthesis for ATG10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610800    OMIM disorders: --

    6 diseases for ATG10:    
    About MalaCards
    myelodysplastic syndromes    acute myeloid leukemia    myeloid leukemia    leukemia
    colorectal cancer    endotheliitis


    ATG10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ATG10
    Human Genome Epidemiology (HuGE) Navigator: ATG10 (1 document)

    Export disorders for ATG10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ATG10 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with ATG10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Stimulation of ATG12-ATG5 conjugation by ribonucleic acid. (PubMed id 16963840)1, 9 Shao Y.... Jiang X. (Autophagy 2007)
    6. Regulation of autophagy by the inositol trisphosphate receptor. (PubMed id 17256008)1, 9 Criollo A....Kroemer G. (Cell Death Differ. 2007)
    7. Inhibition of macroautophagy triggers apoptosis. (PubMed id 15657430)1, 9 Boya P....Kroemer G. (Mol. Cell. Biol. 2005)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Potentially functional polymorphisms in ATG10 are associated with risk of breast cancer in a Chinese population. (PubMed id 23850577)1 Qin Z....Shen H. (Gene 2013)
    10. Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis. (PubMed id 23285162)1 Jo Y.K....Kim J.C. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83734 HGNC: 20315 AceView: APG10L Ensembl:ENSG00000152348 euGenes: HUgn83734
    ECgene: ATG10 Kegg: 83734 H-InvDB: ATG10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ATG10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ATG10 gene:
    Search GeneIP for patents involving ATG10

    GeneCards and IP:
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