Aliases for ATG10 Gene
External Ids for ATG10 Gene
Previous HGNC Symbols for ATG10 Gene
Previous GeneCards Identifiers for ATG10 Gene
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ATG10 Gene
ATG10 (Autophagy Related 10) is a Protein Coding gene. Among its related pathways are Cellular Senescence and mTOR signalling. GO annotations related to this gene include ligase activity and Atg12 transferase activity.
UniProtKB/Swiss-Prot for ATG10 Gene
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.