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Aliases for ATG10 Gene

Aliases for ATG10 Gene

  • Autophagy Related 10 2 3 5
  • Autophagy-Related Protein 10 3 4
  • APG10L 3 4
  • ATG10 Autophagy Related 10 Homolog (S. Cerevisiae) 2
  • APG10 Autophagy 10-Like (S. Cerevisiae) 2
  • Ubiquitin-Like-Conjugating Enzyme ATG10 3
  • ATG10 Autophagy Related 10 Homolog 3
  • APG10 Autophagy 10-Like 3
  • APG10-Like 4
  • EC 6.3.2.- 4
  • Pp12616 3
  • APG10 3

External Ids for ATG10 Gene

Previous HGNC Symbols for ATG10 Gene

  • APG10L

Previous GeneCards Identifiers for ATG10 Gene

  • GC05P081304
  • GC05P081267
  • GC05P076475

Summaries for ATG10 Gene

Entrez Gene Summary for ATG10 Gene

  • Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ATG10 Gene

ATG10 (Autophagy Related 10) is a Protein Coding gene. Among its related pathways are Cellular Senescence and mTOR signalling. GO annotations related to this gene include ligase activity and Atg12 transferase activity.

UniProtKB/Swiss-Prot for ATG10 Gene

  • E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.

Gene Wiki entry for ATG10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ATG10 Gene

Genomics for ATG10 Gene

Regulatory Elements for ATG10 Gene

Enhancers for ATG10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F081970 0.2 ENCODE 44.3 -0.2 -249 2.8 HDGF ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ATG10 ATP6AP1L RPS23 SEM1P1
GH05F081979 1.4 Ensembl ENCODE 30.9 +8.6 8586 1.3 SCRT1 ZNF146 POLR2A SCRT2 POU5F1 ZSCAN29 ETS1 RFX5 ATG10 ATG10-AS1 ATP6AP1L ATG10-IT1
GH05F082018 0.9 Ensembl ENCODE 28.8 +46.7 46676 0.6 ARID4B RAD21 CHAMP1 HSF1 MIXL1 PPARG KAT8 SMARCA4 PBX2 CEBPA ATG10 ATG10-AS1 PPIAP11 GC05P082067
GH05F082340 0.7 ENCODE 26 +368.3 368306 0.6 ATG10 ATP6AP1L GC05M082354 GC05M082258
GH05F082356 1 FANTOM5 Ensembl ENCODE 25.7 +385.5 385476 3.0 PKNOX1 ATF1 ARNT CBX5 GATA2 FOS KDM4B JUNB NCOA1 REST ATG10 ATP6AP1L RPS23 GC05M082354 GC05M082258
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ATG10 on UCSC Golden Path with GeneCards custom track

Promoters for ATG10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001284204 -25 2401 HDGF ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for ATG10 Gene

Chromosome:
5
Start:
81,972,025 bp from pter
End:
82,276,857 bp from pter
Size:
304,833 bases
Orientation:
Plus strand

Genomic View for ATG10 Gene

Genes around ATG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ATG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ATG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ATG10 Gene

Proteins for ATG10 Gene

  • Protein details for ATG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0Y0-ATG10_HUMAN
    Recommended name:
    Ubiquitin-like-conjugating enzyme ATG10
    Protein Accession:
    Q9H0Y0
    Secondary Accessions:
    • B2RE09
    • Q6PIX1
    • Q9H842

    Protein attributes for ATG10 Gene

    Size:
    220 amino acids
    Molecular mass:
    25279 Da
    Quaternary structure:
    • Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity). Interacts with IRGM.
    SequenceCaution:
    • Sequence=BC004551; Type=Frameshift; Positions=26; Evidence={ECO:0000305}; Sequence=BC027718; Type=Frameshift; Positions=26; Evidence={ECO:0000305};

    Alternative splice isoforms for ATG10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ATG10 Gene

Post-translational modifications for ATG10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ATG10 Gene

Domains & Families for ATG10 Gene

Gene Families for ATG10 Gene

Protein Domains for ATG10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ATG10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0Y0

UniProtKB/Swiss-Prot:

ATG10_HUMAN :
  • Belongs to the ATG10 family.
Family:
  • Belongs to the ATG10 family.
genes like me logo Genes that share domains with ATG10: view

Function for ATG10 Gene

Molecular function for ATG10 Gene

UniProtKB/Swiss-Prot Function:
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.

Enzyme Numbers (IUBMB) for ATG10 Gene

Gene Ontology (GO) - Molecular Function for ATG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
GO:0019777 Atg12 transferase activity ISS 20723759
genes like me logo Genes that share ontologies with ATG10: view
genes like me logo Genes that share phenotypes with ATG10: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ATG10 Gene

Localization for ATG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ATG10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ATG10 Gene COMPARTMENTS Subcellular localization image for ATG10 gene
Compartment Confidence
cytosol 5
nucleus 3
lysosome 2
vacuole 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ATG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ATG10: view

Pathways & Interactions for ATG10 Gene

genes like me logo Genes that share pathways with ATG10: view

Pathways by source for ATG10 Gene

1 GeneTex pathway for ATG10 Gene
1 BioSystems pathway for ATG10 Gene
2 Reactome pathways for ATG10 Gene
1 KEGG pathway for ATG10 Gene
2 R&D Systems pathways for ATG10 Gene

SIGNOR curated interactions for ATG10 Gene

Activates:

Gene Ontology (GO) - Biological Process for ATG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006497 protein lipidation ISS,IBA --
GO:0006810 transport IEA --
GO:0006914 autophagy IMP 15657430
GO:0015031 protein transport IEA --
GO:0016236 macroautophagy TAS --
genes like me logo Genes that share ontologies with ATG10: view

Transcripts for ATG10 Gene

Unigene Clusters for ATG10 Gene

Autophagy related 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ATG10 Gene

No ASD Table

Relevant External Links for ATG10 Gene

GeneLoc Exon Structure for
ATG10
ECgene alternative splicing isoforms for
ATG10

Expression for ATG10 Gene

mRNA expression in normal human tissues for ATG10 Gene

Protein differential expression in normal tissues from HIPED for ATG10 Gene

This gene is overexpressed in Bone marrow stromal cell (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ATG10 Gene



Protein tissue co-expression partners for ATG10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ATG10 Gene:

ATG10

SOURCE GeneReport for Unigene cluster for ATG10 Gene:

Hs.713698
genes like me logo Genes that share expression patterns with ATG10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ATG10 Gene

Orthologs for ATG10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ATG10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ATG10 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia ATG10 34
  • 88.74 (n)
MGC138057 35
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ATG10 34 35
  • 88.28 (n)
mouse
(Mus musculus)
Mammalia Atg10 34 16 35
  • 83.81 (n)
rat
(Rattus norvegicus)
Mammalia Atg10 34
  • 82.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ATG10 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ATG10 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves ATG10 34 35
  • 65.44 (n)
lizard
(Anolis carolinensis)
Reptilia ATG10 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia atg10 34
  • 61.35 (n)
zebrafish
(Danio rerio)
Actinopterygii atg10 34 35
  • 53.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5721 34
fruit fly
(Drosophila melanogaster)
Insecta CG12821 35
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea atg-10 35
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG10 34
  • 46.52 (n)
Species where no ortholog for ATG10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ATG10 Gene

ENSEMBL:
Gene Tree for ATG10 (if available)
TreeFam:
Gene Tree for ATG10 (if available)

Paralogs for ATG10 Gene

No data available for Paralogs for ATG10 Gene

Variants for ATG10 Gene

Sequence variations from dbSNP and Humsavar for ATG10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000800 -- 82,054,759(-) CCACA(C/T)AACAA intron-variant, upstream-variant-2KB
rs10036319 -- 82,093,060(+) ACTAT(C/T)CTAAC intron-variant
rs10036653 -- 81,970,563(+) TGTGA(A/T)TTATG upstream-variant-2KB
rs10036914 -- 82,250,054(+) TAAGA(C/T)TGGAT intron-variant
rs10039588 -- 81,993,393(+) ctttt(C/T)ttttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ATG10 Gene

Variant ID Type Subtype PubMed ID
dgv1110e214 CNV gain 21293372
dgv9900n54 CNV gain 21841781
dgv9901n54 CNV loss 21841781
dgv9902n54 CNV gain 21841781
dgv9903n54 CNV gain 21841781
esv1267942 CNV deletion 17803354
esv25341 CNV loss 19812545
esv2669720 CNV deletion 23128226
esv2730388 CNV deletion 23290073
esv2730389 CNV deletion 23290073
esv2730390 CNV deletion 23290073
esv2752082 CNV gain 17911159
esv2759353 CNV loss 17122850
esv3570235 CNV loss 25503493
esv3605606 CNV loss 21293372
esv3605607 CNV loss 21293372
nsv1027178 CNV gain 25217958
nsv1028322 CNV gain 25217958
nsv10712 CNV loss 18304495
nsv328970 CNV insertion 16902084
nsv471018 CNV gain 18288195
nsv477460 CNV novel sequence insertion 20440878
nsv520938 CNV gain 19592680
nsv598753 CNV gain 21841781
nsv598754 CNV gain 21841781
nsv598758 CNV gain 21841781
nsv598761 CNV loss 21841781
nsv598766 CNV gain 21841781
nsv821002 CNV duplication 20802225
nsv830364 CNV loss 17160897
nsv980692 CNV duplication 23825009

Variation tolerance for ATG10 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ATG10 Gene

Human Gene Mutation Database (HGMD)
ATG10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ATG10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ATG10 Gene

Disorders for ATG10 Gene

Relevant External Links for ATG10

Genetic Association Database (GAD)
ATG10
Human Genome Epidemiology (HuGE) Navigator
ATG10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ATG10

No disorders were found for ATG10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ATG10 Gene

Publications for ATG10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Stimulation of ATG12-ATG5 conjugation by ribonucleic acid. (PMID: 16963840) Shao Y. … Jiang X. (Autophagy 2007) 3 22 64
  3. Regulation of autophagy by the inositol trisphosphate receptor. (PMID: 17256008) Criollo A. … Kroemer G. (Cell Death Differ. 2007) 3 22 64
  4. Inhibition of macroautophagy triggers apoptosis. (PMID: 15657430) Boya P. … Kroemer G. (Mol. Cell. Biol. 2005) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ATG10 Gene

Sources for ATG10 Gene

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